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https://www.readbyqxmd.com/read/28415560/gallbladder-papillary-neoplasms-share-pathological-features-with-intraductal-papillary-neoplasm-of-the-bile-duct
#1
Xueshuai Wan, Jie Shi, Anqiang Wang, Yuan Xie, Xiaobo Yang, Chengpei Zhu, Haohai Zhang, Liangcai Wu, Shanshan Wang, Hanchun Huang, Jianzhen Lin, Yongchang Zheng, Zhiyong Liang, Xinting Sang, Haitao Zhao
Intraductal papillary neoplasm of the bile duct (IPNB) has been widely recognized. However, the knowledge of intracystic papillary neoplasm of the gallbladder (IPNG) including papillary adenoma and adenocarcinoma is not well defined. In this study, we compared the clinicopathological and immunohistochemical features between 32 IPNG cases and 32 IPNB cases. IPNG-1 (low-high grade dysplasia) exhibited an earlier onset age, smaller tumor size and lower level of CK20 expression compared to IPNG-2 (invasive carcinoma)...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411367/serum-25-oh-d-concentration-common-variants-of-the-vdr-gene-and-lung-cancer-occurrence
#2
Tomasz Gromowski, Paulina Gapska, Rodney J Scott, Krzysztof Kąklewski, Wojciech Marciniak, Katarzyna Durda, Marcin Lener, Bohdan Górski, Cezary Cybulski, Grzegorz Sukiennicki, Katarzyna Kaczmarek, Katarzyna Jaworska-Bieniek, Katarzyna Paszkowska-Szczur, Piotr Waloszczyk, Jan Lubiński, Tadeusz Dębniak
The first aim of this study was to examine the association between common variants in VDR (rs2228570 (FokI), rs1544410 (BsmI), rs7975232 (ApaI), rs731236 (TaqI), rs11568820 (Cdx2)) and lung cancer risk in the Polish population. Genotyping and statistical analysis which included Chi-square test with Yates correction and haplotype frequency analysis were performed on a series of 840 consecutively collected lung cancer patients and 920 healthy controls. The second aim was to evaluate the link between serum 25(OH)D concentration and the number of lung cancers in a subgroup of 200 patients...
April 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28407860/effects-of-mg132-on-the-in%C3%A2-vitro-development-and-epigenetic-modification-of-debao-porcine-somatic-cell-nuclear-transfer-embryos
#3
Kaiyuan Shen, Xiangping Li, Xiaoli Dai, Ping Wang, Sheng Li, Zhaocheng Xiong, Peifang Chen, Qingyou Liu, Deshun Shi
The present study was undertaken to examine the effect of MG132, a proteasome inhibitor, on the in vitro development, zygotic genome activation (ZGA) and epigenetic modification of Debao porcine somatic cell nuclear transfer (SCNT) embryos. Treatment of oocytes with 1 μM MG132 from 30 h to 42 h of maturation and SCNT embryos with 5 μM MG132 for 2 h after fusion resulted in higher blastocyst yield (36.5%) of SCNT embryos compared with the control group (11.0%). The ZGA of SCNT embryos at 2- and 4-cell stages was also enhanced by MG132 treatment through altering the RNA pol II status and increasing the expression of eIF3A and TFIIA...
May 2017: Theriogenology
https://www.readbyqxmd.com/read/28406723/aspirin-use-and-colorectal-cancer-survival-according-to-tumor-cd274-programmed-cell-death-1-ligand-1-expression-status
#4
Tsuyoshi Hamada, Yin Cao, Zhi Rong Qian, Yohei Masugi, Jonathan A Nowak, Juhong Yang, Mingyang Song, Kosuke Mima, Keisuke Kosumi, Li Liu, Yan Shi, Annacarolina da Silva, Mancang Gu, Wanwan Li, NaNa Keum, Xuehong Zhang, Kana Wu, Jeffrey A Meyerhardt, Edward L Giovannucci, Marios Giannakis, Scott J Rodig, Gordon J Freeman, Daniel Nevo, Molin Wang, Andrew T Chan, Charles S Fuchs, Reiko Nishihara, Shuji Ogino
Purpose Blockade of the programmed cell death 1 (PDCD1, PD-1) immune checkpoint pathway can improve clinical outcomes in various malignancies. Evidence suggests that aspirin (a widely used nonsteroidal anti-inflammatory drug) not only prolongs colorectal cancer survival, but can also activate T cell-mediated antitumor immunity and synergize with immunotherapy through inhibition of prostaglandin E2 production. We hypothesized that the survival benefit associated with aspirin might be stronger in colorectal carcinoma with a lower CD274 (PDCD1 ligand 1, PD-L1) expression level that resulted in lower signaling of the immune checkpoint pathway...
April 13, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28401892/notch-and-hippo-signaling-converge-on-strawberry-notch-1-sbno1-to-synergistically-activate-cdx2-during-specification-of-the-trophectoderm
#5
Yusuke Watanabe, Kota Y Miyasaka, Atsushi Kubo, Yasuyuki S Kida, Osamu Nakagawa, Yoshikazu Hirate, Hiroshi Sasaki, Toshihiko Ogura
The first binary cell fate decision occurs at the morula stage and gives rise to two distinct types of cells that constitute the trophectoderm (TE) and inner cell mass (ICM). The cell fate determinant, Cdx2, is induced in TE cells and plays an essential role in their differentiation and maintenance. Notch and Hippo signaling cascades are assumed to converge onto regulatory elements of Cdx2, however, the underlying molecular mechanisms are largely unknown. Here, we show involvement of Strawberry Notch1 (Sbno1), a novel chromatin factor of the helicase superfamily 2, during preimplantation development...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28394803/hpv-negative-gastric-type-adenocarcinoma-in-situ-of-the-cervix-a-spectrum-of-rare-lesions-exhibiting-gastric-and-intestinal-differentiation
#6
Karen L Talia, Colin J R Stewart, Brooke E Howitt, Marisa R Nucci, W Glenn McCluggage
In recent years, a number of benign and malignant cervical glandular lesions exhibiting gastric differentiation have been described but premalignant gastric-type lesions have not been well characterized. We report a series of 9 cases of a rare form of cervical adenocarcinoma in situ (AIS) distinguished by gastric and sometimes intestinal differentiation and lack of association with human papillomavirus (HPV) infection. The lesions occurred in women aged 25 to 73 years (mean age 51 y). All cases were located at (or just proximal to) the cervical transformation zone and there was extension to the lower uterine segment in 3 cases, 2 of which also involved the endometrium...
April 7, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28393194/metallothionein-1g-promotes-the-differentiation-of-ht-29-human-colorectal-cancer-cells
#7
Juan Martín Arriaga, Alicia Inés Bravo, José Mordoh, Michele Bianchini
Metallothioneins (MTs) are a family of low-molecular-weight, cysteine-rich proteins involved in zinc and redox metabolism, that are epigenetically downregulated during colorectal cancer (CRC) progression, but may be re-induced with a variety of agents. Since loss of MT expression is associated with a worse prognosis, in the present study we investigated the effects of overexpression of the most significantly downregulated isoform in CRC, namely MT1G, on the HT-29 cell line. Overexpression of MT1G resulted in xenograft tumors with an aberrant morphology, characterized by an evident increase in mucin-containing cells that were identified as goblet cells under electron microscopy...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28375564/effects-of-histone-deacetylase-inhibitors-on-regenerative-cell-responses-in-human-dental-pulp-cells
#8
Z Luo, Z Wang, X He, N Liu, B Liu, L Sun, J Wang, F Ma, H Duncan, W He, P Cooper
AIM: To investigate the growth, migratory and adhesive effects of Trichostatin A (TSA) and Valproic acid (VPA), two HDACis, on hDPSCs. METHODOLOGY: To verify that TSA or VPA functions as an HDAC inhibitor, the expressions of histone H3 and H4 were examined using Western blotting analysis. hDPSC growth and metabolic activity was evaluated by MTT viability analysis at different time-points and by cell count experiments. The expression of cell cycle regulatory and the apoptosis associated proteins were examined by Western blot analysis...
April 4, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28373415/detection-of-free-cancer-cells-in-pelvic-lavage-with-double-immunocytochemistry-at-rectal-cancer-surgery
#9
COMPARATIVE STUDY
Csaba Kindler, Kenneth Smedh, Abbas Chabok, Jayant Shetye, George Dafnis, Maziar Nikberg
BACKGROUND/AIM: The aim of the present study was to describe a double immunocytochemical staining method for detecting free cancer cells after rectal cancer surgery and to evaluate their extent and prognostic role. MATERIALS AND METHODS: Immunocytochemistry was performed using antibodies against cytokeratin 20/caudal-typehomeobox transcription factor 2 (CDX2) and mucin glycoprotein-2 (MUC2)/p53 protein. The study included 29 patients with infraperitoneal rectal cancer who underwent bowel resection and four controls...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28369516/comprehensive-chromosome-screening-and-gene-expression-analysis-from-the-same-biopsy-in-human-preimplantation-embryos
#10
Diego Marin, Yujue Wang, Xin Tao, Richard T Scott, Nathan R Treff
STUDY QUESTION: Can simultaneous comprehensive chromosome screening (CCS) and gene expression analysis be performed on the same biopsy of preimplantation human embryos? SUMMARY ANSWER: For the first time, CCS and reliable gene expression analysis have been performed on the same human preimplantation embryo biopsy. WHAT IS KNOWN ALREADY: A single trophectoderm (TE) biopsy is routinely used for many IVF programs offering CCS for selection of only chromosomally normal embryos for transfer...
March 23, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28365970/negative-cdx2-expression-can-be-an-important-predictive-and-prognostic-biomarker-in-stage-ii-colon-cancer
#11
Burak Bilgin, Mehmet A N Sendur, Muhammed B Akinci, Bulent Yalcin
No abstract text is available yet for this article.
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28361317/generation-of-gastrointestinal-organoids-from-human-pluripotent-stem-cells
#12
Jorge O Múnera, James M Wells
Over the past several decades, developmental biologists have discovered fundamental mechanisms by which organs form in developing embryos. With this information it is now possible to generate human "organoids" by the stepwise differentiation of human pluripotent stem cells using a process that recapitulates organ development. For the gastrointestinal tract, one of the first key steps is the formation of definitive endoderm and mesoderm, a process that relies on the TGFb molecule Nodal. Endoderm is then patterned along the anterior-posterior axis, with anterior endoderm forming the foregut and posterior endoderm forming the mid and hindgut...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28340228/dual-immunostain-with-satb2-and-ck20-differentiates-appendiceal-mucinous-neoplasms-from-ovarian-mucinous-neoplasms
#13
Zaibo Li, Rachel Roth, Jonathan B Rock, Amy Lehman, William L Marsh, Adrian Suarez, Wendy L Frankel
Objectives: Determination of the primary site of origin for mucinous neoplasms identified in the peritoneal and/or pelvic cavities may be challenging, with major differential diagnoses including appendiceal mucinous neoplasm (AMN) and ovarian mucinous neoplasm (OMN). Special AT-rich sequence binding protein 2 (SATB2) has been shown to be highly selectively expressed in the lower gastrointestinal tract, including the appendix. Methods: We investigated the utility of a dual stain (DS) with SATB2 or caudal type homeobox 2 (CDX2) and cytokeratin 20 (CK20) or villin in distinguishing AMNs from OMNs...
March 18, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28336546/barrett-s-metaplasia-develops-from-cellular-reprograming-of-esophageal-squamous-epithelium-due-to-gastroesophageal-reflux
#14
Carlos D Minacapelli, Manisha Bajpai, Xin Geng, Christina L Cheng, Abhishek A Chouthai, Rhonda F Souza, Stuart Jon Spechler, Kiron M Das
OBJECTIVE: Gastroesophageal reflux disease (GERD) clinically predisposes to columnar Barrett's metaplasia (BM) in the distal esophagus. We demonstrate evidence supporting cellular origin of BM from reprograming or trans-commitment of resident normal esophageal squamous (NES) epithelial cells in response to acid and bile exposure using an in vitro cell culture model. DESIGN: The hTERT-immortalized NES cell line, NES-B10T, was exposed 5 min/day to Acid and Bile (A+B) mixture for 30 weeks...
March 23, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28336164/expression-of-unusual-immunohistochemical-markers-in-mucinous-breast-carcinoma
#15
Rodrigo de Andrade Natal, Sophie F Derchain, Marina Pavanello, Geisilene R Paiva, Luis O Sarian, José Vassallo
BACKGROUND: Mucinous breast carcinoma is characterized by the production of variable amounts of mucin. Some studies have addressed immunohistochemical characterization of mucinous breast carcinoma using a limited set of antibodies. However, the purpose of the present study was to investigate a larger panel of markers not widely used in daily practice and to determine their pathological implications. METHODS: Forty patients diagnosed with mucinous breast carcinoma were enrolled...
March 20, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28328000/cdx2-prognostic-value-in-stage-ii-iii-resected-colon-cancer-is-related-to-cms-classification
#16
C Pilati, J Taieb, R Balogoun, L Marisa, A de Reyniès, P Laurent-Puig
Caudal-type homeobox transcription factor 2 (CDX2) is involved in colon cancer (CC) oncogenesis and has been proposed as a prognostic biomarker in patients with stage II or III CC. We analyzed CDX2 expression in a series of 469 CC typed for the new international consensus molecular subtype (CMS) classification, and we confirmed results in a series of 90 CC. Here, we show that lack of CDX2 expression is only present in the mesenchymal subgroup (CMS4) and in MSI-immune tumors (CMS1) and not in CMS2 and CMS3 colon cancer...
February 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28322096/cdx2-immunostaining-in-primary-and-metastatic-germ-cell-tumours-of-the-testis
#17
Fatma Oz Atalay, Berna Aytac Vuruskan, Hakan Vuruskan
Objective To evaluate the immunohistochemical staining pattern of caudal type homeobox 2 (CDX2) protein in germ cell tumours (GCTs) of the testis. Methods This study reassessed archival tissue samples collected from patients diagnosed with primary and metastatic testicular GCTs for CDX2 immunoreactivity using standard immunohistochemical techniques. Positive nuclear immunostaining was evaluated with regard to both the staining intensity and the extent of the staining. Results Tissue sections from primary and metastatic testicular GCTs ( n = 104), germ cell neoplasia in situ (GCNis) ( n = 5) and benign testicles ( n = 15) were analysed...
December 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/28321513/clinicopathological-features-of-superficial-non-ampurally-duodenal-epithelial-tumor-gastric-phenotype-of-histology-correlates-to-higher-malignant-potency
#18
Takahito Toba, Naoko Inoshita, Mitsuru Kaise, Kosuke Nomura, Yasutaka Kuribayashi, Masami Tanaka, Satoshi Yamashita, Tsukasa Furuhata, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani, Toshiro Iizuka, Shu Hoteya
BACKGROUND: Superficial non-ampullary duodenal epithelial tumors (SNADETs) are relatively rare, but they are now being detected more frequently due to advances in endoscopic technology. Nevertheless, the pathological nature of SNADETs remains unclear and a management strategy for these tumors has not been established. METHODS: To elucidate the clinicopathological features, we conducted a retrospective analysis of 138 endoscopically resected SNADETs. Lesions were classified into two groups by histological grade according to the Vienna classification: category 3 (71 lesions, 51...
March 20, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28295004/-serrated-adenomas-of-the-colon-clinical-morphological-and-molecular-genetic-characteristics
#19
L M Mikhaleva, R A Komleva, A E Biryukov, N K Shakhpazyan
AIM: to investigate the clinical, morphological, and molecular genetic characteristics of serrated adenomas of the colon. MATERIAL AND METHODS: The study included 82 colon adenomas from 63 patients aged 29 to 81 years, who underwent colonoscopy with biopsy or polypectomy. The mean age of men was 63.3 years; that of women was 56.8 years. Comprehensive clinical, morphological, immunohistochemical, and molecular genetic examinations were made. RESULTS: The histological examination showed that sessile serrated adenomas (SSA) of the colon were most common (46...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28278514/distinct-clinical-outcomes-of-two-cimp-positive-colorectal-cancer-subtypes-based-on-a-revised-cimp-classification-system
#20
Jeong Mo Bae, Jung Ho Kim, Yoonjin Kwak, Dae-Won Lee, Yongjun Cha, Xianyu Wen, Tae Hun Lee, Nam-Yun Cho, Seung-Yong Jeong, Kyu Joo Park, Sae Won Han, Hye Seung Lee, Tae-You Kim, Gyeong Hoon Kang
BACKGROUND: Colorectal cancer (CRC) is a heterogeneous disease in terms of molecular carcinogenic pathways. Based on recent findings regarding the multiple serrated neoplasia pathway, we revised an eight-marker panel for a new CIMP classification system. METHODS: 1370 patients who received surgical resection for CRCs were classified into three CIMP subtypes (CIMP-N: 0-4 methylated markers, CIMP-P1: 5-6 methylated markers and CIMP-P2: 7-8 methylated markers). Our findings were validated in a separate set of high-risk stage II or stage III CRCs receiving adjuvant fluoropyrimidine plus oxaliplatin (n=950)...
April 11, 2017: British Journal of Cancer
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