keyword
https://read.qxmd.com/read/37657657/host-aldh2-deficiency-aggravates-nonalcoholic-steatohepatitis-through-gut-liver-axis
#21
JOURNAL ARTICLE
Zhan-Ming Li, Chao-Yue Kong, Yu-Qin Mao, Hui-Ling Chen, Shi-Long Zhang, Jia-Ting Huang, Jin-Qing Yao, Pei-Ran Cai, Nuo Xie, Bing Han, Li-Shun Wang
Nonalcoholic steatohepatitis (NASH) is the major cause of liver dysfunction. Animal and population studies have shown that mitochondrial aldehyde dehydrogenase (ALDH2) is implicated in fatty liver disease. However, the role of ALDH2 in NASH and the underlying mechanisms remains unclear. To address this issue, ALDH2 knockout (ALDH2-/- ) mice and wild-type littermate mice were fed a methionine-and choline-deficient (MCD) diet to induce a NASH model. Fecal, serum, and liver samples were collected and analyzed to investigate the impact of the gut microbiota and bile acids on this process...
August 30, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/37599938/zhuyu-pill-alleviates-nonalcoholic-fatty-liver-disease-by-regulating-bile-acid-metabolism-through-the-gut-liver-axis
#22
JOURNAL ARTICLE
Lu Xu, Kunhe Xu, Peiyu Xiong, Chun Zhong, Xiaobo Zhang, Rui Gao, Xin Zhou, Tao Shen
AIM: The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide, but there are currently limited treatment options available. Therefore, it is necessary to research new treatment strategies. Zhuyu Pill (ZYP) is a well-known herbal recipe consisting of Huanglian (Coptidis rhizoma) and Wuzhuyu (Evodiae Fructus) that has been clinically used to treat NAFLD. This study aimed to investigate the impact of ZYP on NAFLD induced by a high-fat diet (HFD) and to identify its potential mechanism...
August 15, 2023: ACS Omega
https://read.qxmd.com/read/37572734/glp-2-improves-hepatic-inflammation-and-fibrosis-in-mdr2-mice-via-activation-of-nr4a1-nur77-in-hepatic-stellate-cells-and-intestinal-fxr-signaling
#23
JOURNAL ARTICLE
Claudia D Fuchs, Thierry Claudel, Veronika Mlitz, Alessandra Riva, Moritz Menz, Ksenia Brusilovskaya, Felix Haller, Maximilian Baumgartner, Philipp Königshofer, Lukas W Unger, Wilhelm Sjöland, Hubert Scharnagl, Tatjana Stojakovic, Georg Busslinger, Thomas Reiberger, Hanns-Ulrich Marschall, Michael Trauner
BACKGROUND & AIMS: Glucagon-like peptide (GLP)-2 may exert antifibrotic effects on hepatic stellate cells (HSCs). Thus, we aimed to test whether application of the GLP-2 analogue teduglutide has hepatoprotective and antifibrotic effects in the Mdr2/Abcb4-/- mouse model of sclerosing cholangitis displaying hepatic inflammation and fibrosis. METHODS: Mdr2-/- mice were injected daily for 4 weeks with teduglutide followed by gene expression profiling (bulk liver; isolated HSCs) and immunohistochemistry...
August 10, 2023: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/37558739/lactobacillus-oris-improves-non-alcoholic-fatty-liver-in-mice-and-inhibits-endogenous-cholesterol-biosynthesis
#24
JOURNAL ARTICLE
Yiming Zhao, Congyong Li, Zhe Luan, Jun Chen, Cong Wang, Yujia Jing, Shirui Qi, Zhizhuang Zhao, Hanwen Zhang, Junling Wu, Yi Chen, Zhuanyu Li, Bowen Zhao, Shufang Wang, Yunsheng Yang, Gang Sun
We previously confirmed that a strain of Lactobacillus oris isolated from the fecal samples of healthy Hainan centenarian having potent lipid-lowering ability in HepG2 cells; and this study was to investigate the effect of the stain on non-alcoholic fatty liver in mice in vivio. The Lactobacillus oris strain isolated from Hainan centenarian fecal samples were frozen stored in our laboratory. Thirty ob/ob mice (10 in each group) were orally gavaged with Lactobacillus oris (Lactobacillus, 5 × 109  cfu), mixed probiotics (Mixed, 5 × 109  cfu, a mixture with known lipid-lowering ability), or culture medium (Control) respectively...
August 9, 2023: Scientific Reports
https://read.qxmd.com/read/37482263/protective-effects-of-scutellaria-coptis-herb-couple-against-non-alcoholic-steatohepatitis-via-activating-nrf2-and-fxr-pathways-in-vivo-and-in-vitro
#25
JOURNAL ARTICLE
Yanan Xue, Yue Wei, Lan Cao, Min Shi, Junqing Sheng, Qin Xiao, Ziwen Cheng, Tao Luo, Quanhui Jiao, Ailan Wu, Chen Chen, Lingyun Zhong, Changhua Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Scutellaria-coptis herb couple (SC) is a classic herbal pair used in many Traditional Chinese Medicine (TCM) formulations in the treatment of endocrine and metabolic deseases. Diabetes mellitus and non-alcoholic steatohepatitis (NASH) are both endocrine and metabolic diseases. Previous studies have shown that SC has anti-diabetic effects. However, the effect and mechanism of SC against NASH remains unclear. AIM OF THE STUDY: This study aimed to demonstrate the effect and mechanism of SC against NASH through the nuclear factor-erythroid 2-related factor 2 (Nrf2) and farnesoid X receptor (FXR) dual signaling pathways in vivo and in vitro...
July 22, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37429516/hyodeoxycholic-acid-attenuates-cholesterol-gallstone-formation-via-modulation-of-bile-acid-metabolism-and-gut-microbiota
#26
JOURNAL ARTICLE
Shuang Shen, Dan Huang, Shengnan Qian, Xin Ye, Qian Zhuang, Xinjian Wan, Zhixia Dong
BACKGROUND & AIMS: Hyodeoxycholic acid (HDCA), a hydrophilic bile acid (BA), may prevent and suppress the formation of cholesterol gallstones (CGs). However, the mechanism by which HDCA prevents CGs formation remains unclear. This study aimed to investigate the underlying mechanism of HDCA in preventing CG formation. METHODS: C57BL/6J mice were fed either a lithogenic diet (LD), a chow diet, or LD combined with HDCA. The concentration of BAs in the liver and ileum were determined using liquid chromatography-mass spectrometry (LC-MS/MS)...
July 8, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37419267/lysimachia-christinae-polysaccharide-attenuates-diet-induced-hyperlipidemia-via-modulating-gut-microbes-mediated-fxr-fgf15-signaling-pathway
#27
JOURNAL ARTICLE
Yong-Fei Zhou, Jiaojiao Nie, Chao Shi, Wei-Wei Zheng, Ke Ning, Jing Kang, Ji-Xiang Sun, Xiaoqiang Cong, Qiuhong Xie, Hongyu Xiang
Polysaccharides are one of the most abundant and active components of Lysimachia christinae (L. christinae), which is widely adopted for attenuating abnormal cholesterol metabolism; however, its mechanism of action remains unclear. Therefore, we fed a natural polysaccharide (NP) purified from L. christinae to high-fat diet mice. These mice showed an altered gut microbiota and bile acid pool, which was characterized by significantly increased Lactobacillus murinus and unconjugated bile acids in the ileum. Oral administration of the NP reduced cholesterol and triglyceride levels and enhanced bile acid synthesis via cholesterol 7α-hydroxylase...
July 5, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37377582/fibroblast-growth-factor-15-induced-by-elevated-bile-acids-mediates-the-improvement-of-hepatic-glucose-metabolism-after-sleeve-gastrectomy
#28
JOURNAL ARTICLE
Meng Wei, Wei-Bo Cao, Ru-Dong Zhao, Dan-Ping Sun, Yi-Ze Liang, Ya-Di Huang, Ze-Wei Cheng, Jun Ouyang, Wen-Shuo Yang, Wen-Bin Yu
BACKGROUND: Fibroblast growth factor (FGF) 15/19, which is expressed in and secreted from the distal ileum, can regulate hepatic glucose metabolism in an endocrine manner. The levels of both bile acids (BAs) and FGF15/19 are elevated after bariatric surgery. However, it is unclear whether the increase in FGF15/19 is induced by BAs. Moreover, it remains to be understood whether FGF15/19 elevations contribute to improvements in hepatic glucose metabolism after bariatric surgery. AIM: To investigate the mechanism of improvement of hepatic glucose metabolism by elevated BAs after sleeve gastrectomy (SG)...
June 7, 2023: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/37377410/akkermansia-muciniphila-alleviates-high-fat-diet-related-metabolic-associated-fatty-liver-disease-by-modulating-gut-microbiota-and-bile-acids
#29
JOURNAL ARTICLE
Wenrui Wu, Wang Kaicen, Xiaoyuan Bian, Liya Yang, Shi Ding, Yating Li, Shengjie Li, Aoxiang Zhuge, Lanjuan Li
It has been reported that Akkermansia muciniphila improves host metabolism and reduces inflammation; however, its potential effects on bile acid metabolism and metabolic patterns in metabolic-associated fatty liver disease (MAFLD) are unknown. In this study, we have analysed C57BL/6 mice under three feeding conditions: (i) a low-fat diet group (LP), (ii) a high-fat diet group (HP) and (iii) a high-fat diet group supplemented with A. muciniphila (HA). The results found that A. muciniphila administration relieved weight gain, hepatic steatosis and liver injury induced by the high-fat diet...
June 28, 2023: Microbial Biotechnology
https://read.qxmd.com/read/37348559/transgenic-mice-lacking-fgf15-19-shp-phosphorylation-display-altered-bile-acids-and-gut-bacteria-promoting-nonalcoholic-fatty-liver-disease
#30
JOURNAL ARTICLE
Young-Chae Kim, Ming Qi, Xingchen Dong, Sunmi Seok, Hao Sun, Byron Kemper, Ting Fu, Jongsook Kim Kemper
Dysregulated bile acid (BA)/lipid metabolism and gut bacteria dysbiosis are tightly associated with the development of obesity and non-alcoholic fatty liver disease (NAFLD). The orphan nuclear receptor, Small Heterodimer Partner (SHP/NR0B2), is a key regulator of BA/lipid metabolism, and its gene-regulating function is markedly enhanced by phosphorylation at Thr-58 mediated by a gut hormone, fibroblast growth factor-15/19 (FGF15/19). To investigate the role of this phosphorylation in whole-body energy metabolism, we generated transgenic SHP-T58A knock-in mice...
June 20, 2023: Journal of Biological Chemistry
https://read.qxmd.com/read/37308953/roles-of-bile-acids-signaling-in-neuromodulation-under-physiological-and-pathological-conditions
#31
REVIEW
Chen Xing, Xin Huang, Dongxue Wang, Dengjun Yu, Shaojun Hou, Haoran Cui, Lung Song
Bile acids (BA) are important physiological molecules not only mediating nutrients absorption and metabolism in peripheral tissues, but exerting neuromodulation effect in the central nerve system (CNS). The catabolism of cholesterol to BA occurs predominantly in the liver by the classical and alternative pathways, or in the brain initiated by the neuronal-specific enzyme CYP46A1 mediated pathway. Circulating BA could cross the blood brain barrier (BBB) and reach the CNS through passive diffusion or BA transporters...
June 12, 2023: Cell & Bioscience
https://read.qxmd.com/read/37292154/-bacteroides-dorei-bdx-01-alleviates-dss-induced-experimental-colitis-in-mice-by-regulating-intestinal-bile-salt-hydrolase-activity-and-the-fxr-nlrp3-signaling-pathway
#32
JOURNAL ARTICLE
Xiaowei Sun, Zhenhui Chen, Lu Yu, Weisen Zeng, Boyuan Sun, Hongying Fan, Yang Bai
Background: The relationships among intestinal dysbiosis, bile acid (BA) metabolism disorders, and ulcerative colitis pathogenesis are now recognized. However, how specific strains regulate BA metabolism to alleviate colitis is still unclear. This study investigated the effects of Bacteroides dorei on the development of acute colitis and elucidated the underlying mechanisms. Methods: The safety of BDX-01 was evaluated in vitro and in vivo . 2.5% dextran sulfate sodium (DSS) induced colitis in C57BL/6 mice, Caco-2, and J774A...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37249474/parp-1-inhibitor-alleviates-liver-lipid-accumulation-of-atherosclerosis-via-modulating-bile-acid-metabolism-and-gut-microbes
#33
JOURNAL ARTICLE
Yingkun Sheng, Guibing Meng, Zhirong Zhou, Ruijiao Du, Yuefei Wang, Miaomiao Jiang
Background : The DNA damage repair enzyme, poly(ADP-ribose) polymerase 1 (PARP1), is crucial for lipid and glucose metabolism. However, no evidence has been presented on the relationship between liver lipid accumulation and the PARP1 inhibitor, 3-aminobenzamide (3-AB), in atherosclerosis. Methods : ApoE -/- mice were used to explore the effect of 3-AB on atherosclerotic liver lipid accumulation, and the experiment of Sprague Dawley (SD) rats was designed to determine if the lowering of liver lipid levels by 3-AB was linked to gut bacteria...
May 30, 2023: Molecular Omics
https://read.qxmd.com/read/37202792/therapeutic-mechanisms-of-the-medicine-and-food-homology-formula-xiao-ke-yin-on-glucolipid-metabolic-dysfunction-revealed-by-transcriptomics-metabolomics-and-microbiomics-in-mice
#34
JOURNAL ARTICLE
Mei Li, Ding Cheng, Chuan Peng, Yujiao Huang, Jie Geng, Guangrui Huang, Ting Wang, Anlong Xu
BACKGROUND: In recent decades, the prevalence of metabolic diseases, particularly diabetes, hyperlipidemia, obesity, and non-alcoholic fatty liver disease (NAFLD), has increased dramatically, causing great public health and economic burdens worldwide. Traditional Chinese medicine (TCM) serves as an effective therapeutic choice. Xiao-Ke-Yin (XKY) is a medicine and food homology TCM formula consisting of nine "medicine and food homology" herbs and is used to ameliorate metabolic diseases, such as insulin resistance, diabetes, hyperlipidemia and NAFLD...
May 18, 2023: Chinese Medicine
https://read.qxmd.com/read/37171157/mapping-early-serum-proteome-signatures-of-liver-regeneration-in-living-donor-liver-transplant-cases
#35
JOURNAL ARTICLE
Lorena Carmona-Rodríguez, Aaron S Gajadhar, Irene Blázquez-García, Laura Guerrero, Manuel A Fernández-Rojo, Iker Uriarte, Maricruz Mamani-Huanca, Ángeles López-Gonzálvez, Sergio Ciordia, Antonio Ramos, José Ignacio Herrero, Maite G Fernández-Barrena, María Arechederra, Carmen Berasain, Jorge Quiroga, Bruno Sangro, Josepmaría Argemi, Fernando Pardo, Fernando Rotellar, Daniel López, Coral Barbas, Matías A Ávila, Fernando J Corrales
The liver is the only solid organ capable of regenerating itself to regain 100% of its mass and function after liver injury and/or partial hepatectomy (PH). This exceptional property represents a therapeutic opportunity for severe liver disease patients. However, liver regeneration (LR) might fail due to poorly understood causes. Here, we have investigated the regulation of liver proteome and phosphoproteome at a short time after PH (9 h), to depict a detailed mechanistic background of the early LR phase...
May 12, 2023: BioFactors
https://read.qxmd.com/read/37166409/dietary-isoquercetin-reduces-hepatic-cholesterol-and-triglyceride-in-nafld-mice-by-modulating-bile-acid-metabolism-via-intestinal-fxr-fgf15-signaling
#36
JOURNAL ARTICLE
Ce Zhang, Zunji Shi, Hehua Lei, Fang Wu, Chuan Chen, Zheng Cao, Yuchen Song, Cui Zhang, Jinlin Zhou, Yujing Lu, Limin Zhang
Isoquercetin, a monosaccharide flavonoid, was recently reported to have significant amelioration effects on high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) of mice. However, the underlying mechanism of hepatic cholesterol and triglyceride improvement in mice fed HFD by isoquercetin remains unclear. Here, a combination of 16S rRNA gene sequencing, targeted quantification of bile acids (BAs), and biological assays was employed to investigate the beneficial effects of isoquercetin on NAFLD in mice...
May 11, 2023: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/37149065/yinchen-decoction-protects-against-cholic-acid-diet-induced-cholestatic-liver-injury-in-mice-through-liver-and-ileal-fxr-signaling
#37
JOURNAL ARTICLE
Guochao Song, Bin Zou, Jing Zhao, Fengyi Weng, Yue Li, Xiaoqing Xu, Shuang Zhang, Dongming Yan, Jingyi Jin, Xin Sun, Chenghai Liu, Furong Qiu
ETHNOPHARMACOLOGICAL RELEVANCE: Cholestasis is a pathophysiological syndrome characterized by the accumulation of bile acids (BAs) that leads to severe liver disease. Artemisia capillaris is documented in Chinese Pharmacopoeia as the authentic resources for Yinchen. Although Yinchen (Artemisia capillaris Thunb.) decoction (YCD) has been used in China for thousands of years to treat jaundice, the underlying mechanisms to ameliorate cholestatic liver injury have not been elucidated. AIM OF THE STUDY: To investigate the molecular mechanism of how YCD protects against 1% cholic acid (CA) diet-induced intrahepatic cholestasis through FXR signaling...
September 15, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37148862/reshaping-the-gut-microbiome-and-bile-acid-composition-by-gyejibongnyeong-hwan-ameliorates-western-diet-induced-dyslipidemia
#38
JOURNAL ARTICLE
So Min Lee, You Mee Ahn, Seong-Hwan Park, Sarah Shin, Jeeyoun Jung
Gyejibongnyeong-hwan (GBH), a traditional Chinese medicine, is used in clinical practice to treat blood stasis in metabolic diseases. Herein, we examined the effects of GBH on dyslipidemia and investigated the underlying mechanisms by focusing on modulation of the gut microbiota-bile acid axis by GBH. We utilized a Western diet-induced dyslipidemia mouse model and divided animals into the following four groups (n = 5 each): the normal chow diet, vehicle control (WD), simvastatin (Sim, 10 mg/kg/day simvastatin; positive control), and GBH (GBH, 300 mg/kg/day) groups...
May 4, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37097222/prevention-of-high-fat-diet-induced-dyslipidemia-by-lactobacillus-plantarum-lp104-through-mediating-bile-acid-enterohepatic-axis-circulation-and-intestinal-flora
#39
JOURNAL ARTICLE
Yu Wang, Xinyue Xing, Yuxuan Ma, Yuling Fan, Yue Zhang, Bo Nan, Xia Li, Yuhua Wang, Jingsheng Liu
This work aimed to investigate the alleviative mechanism of Lactobacillus plantarum LP104 (LP104) isolated from kimchi on high-fat-diet-induced dyslipidemia by targeting the intestinal flora and bile acid (BA) metabolism. Oral administration of LP104 over 8 weeks reduced body weight gain and body fat, as well as ameliorating serum and hepatic dyslipidemia in HFD-fed C57BL/6N mice significantly. LP104 intervention also increased the ileal tauro-α/β-muricholic acid sodium salt (T-α-MCA or T-β-MCA) and tauroursodeoxycholic acid (TUDCA) concentrations to suppress the enterohepatic farnesoid X receptor/fibroblast growth factor 15-fibroblast growth factor receptor 4 (FXR/FGF15-FGFR4) signaling pathway, which stimulated the hepatic cholic acid (CA) and chenodeoxycholic acid (CDCA) de novo synthesis through using cholesterol...
April 25, 2023: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/37082732/farnesoid-x-receptor-is-inhibited-after-ileum-transposition-in-diabetic-rats-its-hypoglycemic-effect
#40
JOURNAL ARTICLE
Weijie Chen, Shengnan Zhou, Jianchun Xiao, Wei Liu, Qiang Qu, Xiaodong He
Background: Aim to investigate bile acid profile changes and the Farnesoid X receptor (FXR) status after ileotransposition (IT), and reveal its possible hypoglycemic mechanism. Methods: Twenty male diabetic rats were randomly assigned into the IT group and the sham IT (SH) group. Bile acid profiles were measured using an ultra-performance liquid chromatography-tandem mass spectrometry. Glucose metabolism was monitored after oral administration of FXR inhibitor and agonist. And the expression of key FXR target genes were measured...
2023: International Journal of Medical Sciences
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