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JOURNAL ARTICLE
Shannon B Juengst, Brittany Wright, Annalyn DeMello, Leia Vos, Fedora Biney, Luis Leon Novelo, Michael Williams
OBJECTIVE: To identify neurobehavioral symptom profiles among persons with chronic traumatic brain injury (TBI) using the Behavioral Assessment Screening Tool (BAST) and to consider participant characteristics that differ between profile groups. SETTING: Community. PARTICIPANTS: Participants (n = 615) were English-speaking adults (≥18) and had a self-reported history of at least one TBI of any severity. DESIGN: Secondary analysis of cross-sectional data...
April 9, 2024: Journal of Head Trauma Rehabilitation
#2
JOURNAL ARTICLE
Gale Whiteneck, William Williams, Emily Almeida, Douglas Bidelspach, William Culpepper, Linda M Picon, C B Eagye, David Dr Mellick
OBJECTIVE: To describe the background, methodology, and results of the congressionally mandated Department of Veterans Affairs (VA) Traumatic Brain Injury (TBI) Veterans Health Registry. SETTING: Veterans Health Administration (VHA) and Veterans Benefit Administration (VBA). PARTICIPANTS: A total of 441 639 Veterans of post-9/11 conflicts who exhibited symptoms associated with TBI and sought care or benefits from the VA between September 2001 and September 2021...
April 1, 2024: Journal of Head Trauma Rehabilitation
#3
JOURNAL ARTICLE
Laraine Winter, Helene Moriarty, Keith M Robinson, Benjamin E Leiby, Krista Schmidt, Christina R Whitehouse, Randel L Swanson
OBJECTIVES: Recovery from traumatic brain injury (TBI) is extremely difficult to predict, with TBI severity usually demonstrating weak predictive validity for functional or other outcomes. A possible explanation may lie in the statistical phenomenon called suppression, according to which a third variable masks the true association between predictor and outcome, making it appear weaker than it actually is. Age at injury is a strong candidate as a suppressor because of its well-established main and moderating effects on TBI outcomes...
April 17, 2024: Journal of Head Trauma Rehabilitation
#4
JOURNAL ARTICLE
Athanasios Tsalatsanis, Clara Dismuke-Greer, Ambuj Kumar, Jeanne Hoffman, Kimberley R Monden, Ulysses Magalang, Daniel Schwartz, Aaron M Martin, Risa Nakase-Richardson
OBJECTIVE: To assess the cost-effectiveness of alternative approaches to diagnose and treat obstructive sleep apnea (OSA) in patients with traumatic brain injury (TBI) during inpatient rehabilitation. SETTING: Data collected during the Comparison of Sleep Apnea Assessment Strategies to Maximize TBI Rehabilitation Participation and Outcome (C-SAS) clinical trial (NCT03033901) on an inpatient rehabilitation TBI cohort were used in this study. STUDY DESIGN: Decision tree analysis was used to determine the cost-effectiveness of approaches to diagnosing and treating sleep apnea...
April 18, 2024: Journal of Head Trauma Rehabilitation
#5
JOURNAL ARTICLE
Katharina Estel, David Alexander Back, Catharina Scheuermann-Poley, Christian Willy
Traumatic heterotopic ossification (HO) of the lower extremity is relatively rare but is of major importance in clinical practice. They are defined as posttraumatic abnormal formations of bone within soft tissue outside of the skeletal system. This article describes the clinical case of a 31-year-old male patient who suffered 2 traumatic events within 12 months-a gunshot wound in the lumbar spine/gluteal region followed by a severe traumatic brain injury with intracranial hemorrhage in a traffic accident as a pedestrian...
April 23, 2024: Military Medicine
#6
JOURNAL ARTICLE
Signe J Eskildsen, Carrinna A Hansen, Thomas Kallemose, Derek J Curtis, Irene Wessel, Ingrid Poulsen
BACKGROUND: Prolonged tracheal tube placement following severe traumatic brain injury (TBI) can cause serious complications. Safe removal requires sufficient ability for independent breathing and airway protection. Thus, identifying important factors for time to removal of the tracheal tube (decannulation) is essential for safe and efficient weaning. This study aimed to identify significant factors for time to decannulation in a Danish population of subjects with tracheostomy after TBI...
April 22, 2024: Respiratory Care
#7
JOURNAL ARTICLE
Samir M Fakhry, Matthew M Carrick, Melissa Red Hoffman, Yan Shen, Jeneva M Garland, Ransom J Wyse, Dorraine D Watts
BACKGROUND: Hospice and palliative care (PC) utilization is increasing in geriatric inpatients, but limited research exists comparing rates among trauma, surgical and medical specialties. The goal of this study was to determine whether there are differences among these three groups in rates of hospice and PC utilization. METHODS: Patients from Centers for Medicare & Medicaid Services (CMS) Inpatient Standard Analytical Files for 2016-2020 aged ≥65 years were analyzed...
2024: Trauma Surgery & Acute Care Open
#8
REVIEW
Tanya Egodage, Purvi Pravinchandra Patel
Traumatic brain injury (TBI) confers significant morbidity and mortality, and is a pathology often encountered by trauma surgeons. Several recent trials have evaluated management protocols of patients with severe TBI. The Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II trial (BOOST-II) evaluated efficacy and feasibility of brain oxygen measurement in severe TBI. BOOST phase 3 trial (BOOST-3) and two ongoing trials look to measure functional outcomes in this population. Furthermore, middle meningeal artery embolization has now become standard therapy for adult patients with chronic subdural hematoma (SDH) and has increasing popularity in those with recurrent SDH as an alternative to surgical intervention...
2024: Trauma Surgery & Acute Care Open
#9
REVIEW
Ali Salim, Bryan A Cotton
Major improvements in trauma care during the last decade have improved survival rates in the severely injured. The unintended consequence is the presentation of patients with non-survivable injuries in a time frame in which intervention is considered and often employed due to prognostic uncertainty. In light of this, discerning survivability in these patients remains increasingly problematic. Evidence-based cut-points of futility can guide early decisions for discontinuing aggressive treatment and use of precious resources in severely injured patients arriving in extremis...
2024: Trauma Surgery & Acute Care Open
#10
JOURNAL ARTICLE
Chiara Mugnier, Marc Guilloux
Severe head trauma, with or without polytrauma, subarachnoid haemorrhage due to aneurysm rupture, is an unexpected tragedy for patients and their families. These accidents are likely to result in extremely serious neurological damage, with many of the patients under our care facing a life-threatening prognosis. To protect the brain, one solution is to put the patient into a deep sleep during the so-called "acute" phase, making it impossible to assess the repercussions of the initial injuries at the time: this is what we call "waiting resuscitation"...
April 2024: Revue de L'infirmière
#11
JOURNAL ARTICLE
Qiang Peng, Lei Wang, Chun-Mei Yu, Xin Chu, Bao-Feng Zhu
Traumatic brain injury (TBI) is a major cause of morbidity and mortality globally. We unveiled the diagnostic value of serum NLRP3, metalloproteinase-9 (MMP-9) and interferon-γ (IFN-γ) levels in post-craniotomy intracranial infections and hydrocephalus in patients with severe craniocerebral trauma to investigate the high risk factors for these in patients with TBI, and the serological factors predicting prognosis, which had a certain clinical predictive value. Study subjects underwent bone flap resection surgery and were categorized into the intracranial infection/hydrocephalus/control (without postoperative hydrocephalus or intracranial infection) groups, with their clinical data documented...
April 21, 2024: Experimental Physiology
#12
JOURNAL ARTICLE
Hamed Abdi, David Sánchez-Molina, Silvia García-Vilana, Vafa Rahimi-Movaghar
Traumatic brain injuries (TBI) resulting from head impacts are a major public health concern, which prompted our research to investigate the complex relationship between the material properties of brain tissue and the severity of TBI. The goal of this research is to investigate how variations in brain and skull density influence the vulnerability of brain tissue to traumatic injury, thereby enhancing our understanding of injury mechanism. To achieve this goal, we employed a well-validated finite element head model (FEHM)...
April 30, 2024: Heliyon
#13
JOURNAL ARTICLE
Randhall B Carteri, Mateus Padilha, Silvaine Sasso de Quadros, Eder Kroeff Cardoso, Mateus Grellert
BACKGROUND: The increase in severe traumatic brain injury (sTBI) incidence is a worldwide phenomenon, resulting in a heavy disease burden in the public health systems, specifically in emerging countries. The shock index (SI) is a physiological parameter that indicates cardiovascular status and has been used as a tool to assess the presence and severity of shock, which is increased in sTBI. Considering the high mortality of sTBI, scrutinizing the predictive potential of SI and its variants is vital...
March 9, 2024: World Journal of Critical Care Medicine
#14
JOURNAL ARTICLE
Christine Eimer, Claas Buschmann, Jonas Deeken, Thoralf Kerner
Management of severe pediatric trauma remains challenging. Injury patterns vary according to patient age and trauma mechanism. This study analyzes trauma mechanisms in deceased pediatric patients. Fatal pediatric trauma cases aged 0-18 years who underwent forensic autopsy in the Federal State of Berlin, Germany, between 2008 until 2018 were enrolled in this retrospective study. Autopsy protocols were analyzed regarding demographic characteristics, trauma mechanisms, injury patterns, resuscitation measures, survival times as well as place, and cause of death...
April 16, 2024: Forensic Science, Medicine, and Pathology
#15
JOURNAL ARTICLE
Süleyman Şahin, Edin Botan, Emrah Gün, Merve Feyza Yüksel, Nurşah Yeniay Süt, Ayşe Tuğba Kartal, Anar Gurbanov, Fevzi Kahveci, Hasan Özen, Merve Havan, Miraç Yıldırım, Seda Kaynak Şahap, Ömer Bektaş, Serap Teber, Suat Fitoz, Tanıl Kendirli
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children. Head computed tomography (CT) is frequently utilized for evaluating trauma-related characteristics, selecting treatment options, and monitoring complications in the early stages. This study assessed the relationship between cranial CT findings and early and late neurological outcomes in pediatric TBI patients admitted to the pediatric intensive care unit (PICU). The study included children aged 1 month to 18 years who were admitted to the PICU due to TBI between 2014 and 2020...
April 15, 2024: Neurological Sciences
#16
Najiha B Farooqi, Sunnie Y W Wong, Simeng Wang, Lisa Marie Knowlton
No abstract text is available yet for this article.
2024: Trauma Surgery & Acute Care Open
#17
JOURNAL ARTICLE
Asanthi M Ratnasekera, Sirivan S Seng, Daniel Kim, Wenyan Ji, Christina L Jacovides, Elinore J Kaufman, Hannah M Sadek, Lindsey L Perea, Christina Monaco Poloni, Ilya Shnaydman, Alexandra Jeongyoon Lee, Victoria Sharp, Angela Miciura, Eric Trevizo, Martin G Rosenthal, Lawrence Lottenberg, William Zhao, Alicia Keininger, Michele Hunt, John Cull, Chassidy Balentine, Tanya Egodage, Aleem T Mohamed, Michelle Kincaid, Stephanie Doris, Robert Cotterman, Sara Seegert, Lewis E Jacobson, Jamie Williams, Melissa Moncrief, Brandi Palmer, Caleb Mentzer, Nichole Tackett, Tjasa Hranjec, Thomas Dougherty, Shawna Morrissey, Lauren Donatelli-Seyler, Amy Rushing, Leah C Tatebe, Tiffany J Nevill, Michel B Aboutanos, David Hamilton, Diane Redmond, Daniel C Cullinane, Carolyne Falank, Mark McMellen, Chris Duran, Jennifer Daniels, Shana Ballow, Kevin M Schuster, Paula Ferrada
BACKGROUND: In patients with severe traumatic brain injury (TBI), clinicians must balance preventing venous thromboembolism (VTE) with the risk of intracranial hemorrhagic expansion (ICHE). We hypothesized that low molecular weight heparin (LMWH) would not increase risk of ICHE or VTE as compared to unfractionated heparin (UH) in patients with severe TBI. METHODS: Patients ≥ 18 years of age with isolated severe TBI (AIS ≥ 3), admitted to 24 level I and II trauma centers between January 1, 2014 to December 31, 2020 and who received subcutaneous UH and LMWH injections for chemical venous thromboembolism prophylaxis (VTEP) were included...
April 9, 2024: Injury
#18
REVIEW
YiLiu Wei, Xiaohan Ren, Zhitao Yuan, Jie Hong, Tao Wang, Weizhi Chen, Yuqing Xu, Jinwang Ding, Jun Lin, Wenqian Jiang, Peng Zhang, Qiaoyi Wu
Trauma is a significant health issue that not only leads to immediate death in many cases but also causes severe complications, such as sepsis, thrombosis, haemorrhage, acute respiratory distress syndrome and traumatic brain injury, among trauma patients. Target protein identification technology is a vital technique in the field of biomedical research, enabling the study of biomolecular interactions, drug discovery and disease treatment. It plays a crucial role in identifying key protein targets associated with specific diseases or biological processes, facilitating further research, drug design and the development of treatment strategies...
April 11, 2024: Expert Reviews in Molecular Medicine
#19
JOURNAL ARTICLE
Ali Mansour, Plamena P Powla, Ronald Alvarado-Dyer, Farima Fakhri, Paramita Das, Peleg Horowitz, Fernando D Goldenberg, Christos Lazaridis
Traumatic brain injury (TBI) is a global health challenge; however, penetrating brain injury (PBI) remains under-represented in evidence-based knowledge and research efforts. This study utilized data from the Trauma Quality Improvement Program (TQIP) of the National Trauma Data Bank (NTDB) to investigate outcomes of PBI as compared with clinical-severity-matched non-penetrating or blunt TBI. A total of 1765 patients with PBI were 1:1 propensity score-matched for clinical severity with blunt TBI patients. The intent of PBI was self-inflicted in 34...
2024: Neurotrauma reports
#20
JOURNAL ARTICLE
Nanda J Patil, Atul B Hulwan, Rohit S Kadam, Sachin Kumar, Chirag R Vadhel
OBJECTIVE: Primary brain injuries, which are the result of severe head trauma and cannot be prevented, are always catastrophic and fatal. Yet, if diagnostic and therapeutic steps are taken promptly after a craniocerebral injury, further brain insults may be prevented and the victim's death can be avoided within 24 hours. MATERIALS AND METHODS: Source of data, sample size, inclusion criteria, exclusion criteria, statistical methods. RESULTS: One hundred individuals with confirmed cumputer tomography (CT) scan results of severe head trauma participated in this analysis...
February 2024: Journal of Pharmacy & Bioallied Sciences
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