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https://www.readbyqxmd.com/read/28917501/personalized-translational-epilepsy-research-novel-approaches-and-future-perspectives-part-i-clinical-and-network-analysis-approaches
#1
REVIEW
Felix Rosenow, Natascha van Alphen, Albert Becker, Andreas Chiocchetti, Ralf Deichmann, Thomas Deller, Thomas Freiman, Christine M Freitag, Johannes Gehrig, Anke M Hermsen, Peter Jedlicka, Christian Kell, Karl Martin Klein, Susanne Knake, Dimitri M Kullmann, Stefan Liebner, Braxton A Norwood, Diana Omigie, Karlheinz Plate, Andreas Reif, Philipp S Reif, Yvonne Reiss, Jochen Roeper, Michael W Ronellenfitsch, Stephanie Schorge, Gerhard Schratt, Stephan W Schwarzacher, Joachim P Steinbach, Adam Strzelczyk, Jochen Triesch, Marlies Wagner, Matthew C Walker, Frederic von Wegner, Sebastian Bauer
Despite the availability of more than 15 new "antiepileptic drugs", the proportion of patients with pharmacoresistant epilepsy has remained constant at about 20-30%. Furthermore, no disease-modifying treatments shown to prevent the development of epilepsy following an initial precipitating brain injury or to reverse established epilepsy have been identified to date. This is likely in part due to the polyetiologic nature of epilepsy, which in turn requires personalized medicine approaches. Recent advances in imaging, pathology, genetics and epigenetics have led to new pathophysiological concepts and the identification of monogenic causes of epilepsy...
September 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28917498/personalized-translational-epilepsy-research-novel-approaches-and-future-perspectives-part-ii-experimental-and-translational-approaches
#2
REVIEW
Sebastian Bauer, Natascha van Alphen, Albert Becker, Andreas Chiocchetti, Ralf Deichmann, Thomas Deller, Thomas Freiman, Christine M Freitag, Johannes Gehrig, Anke M Hermsen, Peter Jedlicka, Christian Kell, Karl Martin Klein, Susanne Knake, Dimitri M Kullmann, Stefan Liebner, Braxton A Norwood, Diana Omigie, Karlheinz Plate, Andreas Reif, Philipp S Reif, Yvonne Reiss, Jochen Roeper, Michael W Ronellenfitsch, Stephanie Schorge, Gerhard Schratt, Stephan W Schwarzacher, Joachim P Steinbach, Adam Strzelczyk, Jochen Triesch, Marlies Wagner, Matthew C Walker, Frederic von Wegner, Felix Rosenow
Despite the availability of more than 15 new "antiepileptic drugs", the proportion of patients with pharmacoresistant epilepsy has remained constant at about 20-30%. Furthermore, no disease-modifying treatments shown to prevent the development of epilepsy following an initial precipitating brain injury or to reverse established epilepsy have been identified to date. This is likely in part due to the polyetiologic nature of epilepsy, which in turn requires personalized medicine approaches. Recent advances in imaging, pathology, genetics, and epigenetics have led to new pathophysiological concepts and the identification of monogenic causes of epilepsy...
September 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28881103/hla-polymorphisms-and-risk-of-red-blood-cell-alloimmunisation-in-polytransfused-patients-with-sickle-cell-anaemia
#3
C Rodrigues, A M Sell, G A S Guelsin, T T Higa, S Pagliarini E Silva, L C Macedo, E Â Sippert, J B de Alencar, Â Zanette, C R L Acorsi, L Castilho, J E L Visentainer
BACKGROUND: Red blood cell (RBC) alloimmunisation is an event that may occur due to factors such as numerous blood transfusions, age, gender and genetic factors such as human leukocyte antigen (HLA). AIMS/OBJECTIVES: The aim of the present study was to investigate the possibility of alloimmunisation to red blood cell group antigens associated with the HLA of individuals and to relate alloimmunisation to risk factors. METHODS: A total of 172 polytransfused patients with sickle cell anaemia (SCA) (44 alloimmunised, 128 non-alloimmunised) participated in this study...
September 7, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28871080/genetically-engineered-red-cells-expressing-single-domain-camelid-antibodies-confer-long-term-protection-against-botulinum-neurotoxin
#4
Nai-Jia Huang, Novalia Pishesha, Jean Mukherjee, Sicai Zhang, Rhogerry Deshycka, Valentino Sudaryo, Min Dong, Charles B Shoemaker, Harvey F Lodish
A short half-life in the circulation limits the application of therapeutics such as single-domain antibodies (VHHs). We utilize red blood cells to prolong the circulatory half-life of VHHs. Here we present VHHs against botulinum neurotoxin A (BoNT/A) on the surface of red blood cells by expressing chimeric proteins of VHHs with Glycophorin A or Kell. Mice whose red blood cells carry the chimeric proteins exhibit resistance to 10,000 times the lethal dose (LD50) of BoNT/A, and transfusion of these red blood cells into naive mice affords protection for up to 28 days...
September 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28869692/the-1-6-7-12-tetraazaperylene-bridging-ligand-as-an-electron-reservoir-and-its-disulfonato-derivative-as-redox-mediator-in-an-enzyme-electrode-process
#5
Thomas Brietzke, Thomas Dietz, Alexandra Kelling, Uwe Schilde, Julianae Bois, Harald Kelm, Manuel Reh, Markus Schmitz, Thomas Körzdörfer, Silke Leimkühler, Ulla Wollenberger, Hans-Jörg Krüger, Hans-Jürgen Holdt
The homodinuclear ruthenium(II) complex [{Ru(l-N4 Me2 )}2 (μ-tape)](PF6 )4 {[1](PF6 )4 } (l-N4 Me2 =N,N'-dimethyl-2,11-diaza[3.3](2,6)-pyridinophane, tape=1,6,7,12-tetraazaperylene) can store one or two electrons in the energetically low-lying π* orbital of the bridging ligand tape. The corresponding singly and doubly reduced complexes [{Ru(l-N4 Me2 )}2 (μ-tape(.-) )](PF6 )3 {[2](PF6 )3 } and [{Ru(l-N4 Me2 )}2 (μ-tape(2-) )](PF6 )2 {[3](PF6 )2 }, respectively, were electrochemically generated, successfully isolated and fully characterized by single-crystal X-ray crystallography, spectroscopic methods and magnetic susceptibility measurements...
September 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28861273/family-connections-versus-optimised-treatment-as-usual-for-family-members-of-individuals-with-borderline-personality-disorder-non-randomised-controlled-study
#6
Daniel Flynn, Mary Kells, Mary Joyce, Paul Corcoran, Sarah Herley, Catalina Suarez, Padraig Cotter, Justina Hurley, Mareike Weihrauch, John Groeger
BACKGROUND: Borderline personality disorder (BPD) is challenging for family members who are often required to fulfil multiple roles such as those of advocate, caregiver, coach and guardian. To date, two uncontrolled studies by the treatment developers suggest that Family Connections (FC) is an effective programme to support, educate and teach skills to family members of individuals with BPD. However, such studies have been limited by lack of comparison to other treatment approaches. This study aimed to compare the effectiveness of FC with an optimised treatment-as-usual (OTAU) programme for family members of individuals with BPD...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28854515/intravenous-immunoglobulin-in%C3%A2-the%C3%A2-management-of-a-rare-cause-of%C3%A2-hemolytic-disease-of-the-newborn-anti-sara-antibodies
#7
R Venkataraman, K Yusuf
Hemolytic disease of newborn (HDN) is a condition that develops in a fetus, when the IgG molecules produced by the mother pass through the placenta and attack the fetal red blood cells. HDN can occur due to Rh and ABO incompatibilities between the mother and the fetus as well as due to other allo-immune antibodies belonging to Kell (K and k), Duffy (Fya), Kidd (Jka and Jkb), and MNS (M, N, S, and s) systems. Role of intravenous immunoglobulin in management of HDN is not clear.SARA red blood cell antigen, first discovered in 1990 is a low frequency antigen...
August 23, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28851981/lipopolysaccharide-binding-protein-lbp-reverses-the-amyloid-state-of-fibrin-seen-in-plasma-of-type-2-diabetics-with-cardiovascular-co-morbidities
#8
Etheresia Pretorius, Sthembile Mbotwe, Douglas B Kell
Type 2 diabetes (T2D) has many cardiovascular complications, including a thrombotic propensity. Many such chronic, inflammatory diseases are accompanied (and may be exacerbated, and possibly even largely caused) by amyloid fibril formation. Recognising that there are few strong genetic associations underpinning T2D, but that amyloidogenesis of amylin is closely involved, we have been seeking to understand what might trigger the disease. Serum levels of bacterial lipopolysaccharide are raised in T2D, and we recently showed that fibrin(ogen) polymerisation during blood clotting can be affected strongly by LPS...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845449/dynamic-conservation-for-migratory-species
#9
Mark D Reynolds, Brian L Sullivan, Eric Hallstein, Sandra Matsumoto, Steve Kelling, Matthew Merrifield, Daniel Fink, Alison Johnston, Wesley M Hochachka, Nicholas E Bruns, Matthew E Reiter, Sam Veloz, Catherine Hickey, Nathan Elliott, Leslie Martin, John W Fitzpatrick, Paul Spraycar, Gregory H Golet, Christopher McColl, Scott A Morrison
In an era of unprecedented and rapid global change, dynamic conservation strategies that tailor the delivery of habitat to when and where it is most needed can be critical for the persistence of species, especially those with diverse and dispersed habitat requirements. We demonstrate the effectiveness of such a strategy for migratory waterbirds. We analyzed citizen science and satellite data to develop predictive models of bird populations and the availability of wetlands, which we used to determine temporal and spatial gaps in habitat during a vital stage of the annual migration...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28842431/testicular-cells-exhibit-similar-molecular-responses-to-cigarette-smoke-condensate-ex-vivo-and-in-vivo
#10
Prabagaran Esakky, Deborah A Hansen, Andrea M Drury, Paul Felder, Andrew Cusumano, Kelle H Moley
Male exposure to cigarette smoke is associated with seminal defects and with congenital anomalies and childhood cancers in offspring. In mice, paternal exposure to cigarette smoke condensate (CSC) causes molecular defects in germ cells and phenotypic effects in their offspring. Here we used an ex vivo testicular explant model and in vivo exposure to determine the concentration at which CSC impairs spermatogenesis and offspring development. We explanted testis tissue at postnatal day (P)5.5 and cultured it until P11...
August 24, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28835220/cardiovascular-magnetic-resonance-feature-tracking-in-small-animals-a-preliminary-study-on-reproducibility-and-sample-size-calculation
#11
Tomas Lapinskas, Jana Grune, Seyedeh Mahsa Zamani, Sarah Jeuthe, Daniel Messroghli, Rolf Gebker, Heike Meyborg, Ulrich Kintscher, Remigijus Zaliunas, Burkert Pieske, Philipp Stawowy, Sebastian Kelle
BACKGROUND: Cardiovascular magnetic resonance feature tracking (CMR-FT) is a novel tissue tracking technique developed for noninvasive assessment of myocardial motion and deformation. This preliminary study aimed to evaluate the observer's reproducibility of CMR-FT in a small animal (mouse) model and define sample size calculation for future trials. METHODS: Six C57BL/6 J mice were selected from the ongoing experimental mouse model onsite and underwent CMR with a 3 Tesla small animal MRI scanner...
August 23, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28821731/stability-in-metabolic-phenotypes-and-inferred-metagenome-profiles-before-the-onset-of-colitis-induced-inflammation
#12
M Glymenaki, A Barnes, S O' Hagan, G Warhurst, A J McBain, I D Wilson, D B Kell, K J Else, S M Cruickshank
Inflammatory bowel disease (IBD) is associated with altered microbiota composition and metabolism, but it is unclear whether these changes precede inflammation or are the result of it since current studies have mainly focused on changes after the onset of disease. We previously showed differences in mucus gut microbiota composition preceded colitis-induced inflammation and stool microbial differences only became apparent at colitis onset. In the present study, we aimed to investigate whether microbial dysbiosis was associated with differences in both predicted microbial gene content and endogenous metabolite profiles...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794062/high-quality-de-novo-genome-assembly-of-the-dekkera-bruxellensis-yeast-isolate-using-nanopore-minion-sequencing
#13
Téo Fournier, Jean-Sébastien Gounot, Kelle Freel, Corinne Cruaud, Arnaud Lemainque, Jean-Marc Aury, Patrick Wincker, Joseph Schacherer, Anne Friedrich
Genetic variation in natural populations represents the raw material for phenotypic diversity. Species-wide characterization of genetic variants is crucial to have a deeper insight into the genotype-phenotype relationship. With the advent of new sequencing strategies and more recently the release of long-read sequencing platforms, it is now possible to explore the genetic diversity of any non-model organisms, representing a fundamental resource for biological research. In the frame of population genomic surveys, a first step is to obtain the complete sequence and high quality assembly of a reference genome...
August 9, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28793102/deaths-among-the-elderly-with-icu-infections
#14
Álvaro Francisco Lopes de Sousa, Artur Acelino Francisco Luz Nunes Queiroz, Layze Braz de Oliveira, Luana Kelle Batista Moura, Denise de Andrade, Evandro Watanabe, Maria Eliete Batista Moura
Objective: to evaluate the clinical outcome of elderly patients admitted to intensive care units who had nosocomial infection, correlating the findings with sociodemographic and clinical variables. Method: descriptive research, performed with 308 elderly patients. The collection was made from medical records and covers the years 2012 to 2015. Uni-/bivariate analyses were performed. Results: a statistical association was found between the clinical outcome types and the variables age, length of stay, presence of previous comorbidities, main diagnosis, respiratory and urinary tract infections, use of central venous and indwelling urinary catheters, mechanical ventilation, and tracheostomy...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28778104/to-what-extent-are-the-terminal-stages-of-sepsis-septic-shock-systemic-inflammatory-response-syndrome-and-multiple-organ-dysfunction-syndrome-actually-driven-by-a-prion-amyloid-form-of-fibrin
#15
Douglas B Kell, Etheresia Pretorius
No abstract text is available yet for this article.
August 4, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28766908/building-essential-biodiversity-variables-ebvs-of-species-distribution-and-abundance-at-a-global-scale
#16
W Daniel Kissling, Jorge A Ahumada, Anne Bowser, Miguel Fernandez, Néstor Fernández, Enrique Alonso García, Robert P Guralnick, Nick J B Isaac, Steve Kelling, Wouter Los, Louise McRae, Jean-Baptiste Mihoub, Matthias Obst, Monica Santamaria, Andrew K Skidmore, Kristen J Williams, Donat Agosti, Daniel Amariles, Christos Arvanitidis, Lucy Bastin, Francesca De Leo, Willi Egloff, Jane Elith, Donald Hobern, David Martin, Henrique M Pereira, Graziano Pesole, Johannes Peterseil, Hannu Saarenmaa, Dmitry Schigel, Dirk S Schmeller, Nicola Segata, Eren Turak, Paul F Uhlir, Brian Wee, Alex R Hardisty
Much biodiversity data is collected worldwide, but it remains challenging to assemble the scattered knowledge for assessing biodiversity status and trends. The concept of Essential Biodiversity Variables (EBVs) was introduced to structure biodiversity monitoring globally, and to harmonize and standardize biodiversity data from disparate sources to capture a minimum set of critical variables required to study, report and manage biodiversity change. Here, we assess the challenges of a 'Big Data' approach to building global EBV data products across taxa and spatiotemporal scales, focusing on species distribution and abundance...
August 2, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28755141/locoregional-recurrence-following-breast-cancer-surgery-in-the-trastuzumab-era-a-systematic-review-by-subtype
#17
Andrew McGuire, Aoife J Lowery, Malcolm R Kell, Michael J Kerin, Karl J Sweeney
INTRODUCTION: Increasing evidence suggests that molecular subtype influences locoregional recurrence (LRR) of breast cancer. Previous systematic reviews that evaluated the quantitative influence of subtype on LRR predated the use of Trastuzumab. This study assessed the impact of subtype on LRR in a contemporary treatment era. METHODS: A comprehensive search for all published studies assessing LRR according to breast cancer subtype was performed. Only studies with patients treated with Trastuzumab were included...
July 28, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28754062/procedures-and-protocols-for-weight-assessment-during-acute-illness-in-individuals-with-anorexia-nervosa-a-national-survey
#18
Susan Kelly-Weeder, Meredith Kells, Karen Jennings, Julie Dunne, Barbara Wolfe
BACKGROUND: Weight assessment is a key component of nursing care for individuals with the acute illness of anorexia nervosa (AN). However, there is little data to guide protocols and procedures regarding weight assessment. OBJECTIVE: To describe institutional practices regarding weight assessment of individuals during acute illness of AN. DESIGN: Treatment facilities ( N = 24) completed a survey about written protocols and procedures regarding weight assessment and disclosure of weight to patients...
July 1, 2017: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/28736872/global-change-and-the-distributional-dynamics-of-migratory-bird-populations-wintering-in-central-america
#19
Frank A La Sorte, Daniel Fink, Peter J Blancher, Amanda D Rodewald, Viviana Ruiz-Gutierrez, Kenneth V Rosenberg, Wesley M Hochachka, Peter H Verburg, Steve Kelling
Understanding the susceptibility of highly mobile taxa such as migratory birds to global change requires information on geographic patterns of occurrence across the annual cycle. Neotropical migrants that breed in North America and winter in Central America occur in high concentrations on their non-breeding grounds where they spend the majority of the year and where habitat loss has been associated with population declines. Here, we use eBird data to model weekly patterns of abundance and occurrence for 21 forest passerine species that winter in Central America...
July 24, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28735826/affron-%C3%A2-a-novel-saffron-extract-crocus-sativus-l-improves-mood-in-healthy-adults-over-4-weeks-in-a-double-blind-parallel-randomized-placebo-controlled-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Graham Kell, Amanda Rao, Gavin Beccaria, Paul Clayton, Antonio Manuel Inarejos-García, Marin Prodanov
BACKGROUND: In recent years phytotherapy has been explored as a source for alternative treatments for mood disorders. One potential candidate is saffron (Crocus sativus L.), whose main bioactive components are crocins and safranal. OBJECTIVES: The aim of this study was to investigate the efficacy of affron(®), a standardised stigmas extract from Crocus sativus L. for improving mood, stress, anxiety and sleep quality in healthy adults. METHODS: In this 3 arm study, 128 participants self-reporting low mood but not diagnosed with depression, were given affron(®) at 28mg/day, 22mg/day, or a placebo treatment in a randomized, double-blind, placebo-controlled trial for 4 weeks...
August 2017: Complementary Therapies in Medicine
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