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https://www.readbyqxmd.com/read/28531352/conformational-complexity-in-the-lh2-antenna-of-the-purple-sulfur-bacterium-allochromatium-vinosum-revealed-by-hole-burning-spectroscopy
#1
Adam Kell, Mahboobe Jassas, Khem Acharya, Kirsty Hacking, Richard J Cogdell, Ryszard J Jankowiak
This work discusses the protein conformational complexity of the B800-850 LH2 complexes from the purple sulfur bacterium Allochromatium vinosum, focusing on the spectral characteristics of the B850 chromophores. Low-temperature B850 absorption and the split B800 band shift blue and red, respectively, at elevated temperatures, revealing isosbestic points. The latter indicates the presence of two (unresolved) conformations of B850 bacteriochlorophylls (BChls), referred to as conformations 1 and 2, and two conformations of B800 BChls, denoted as B800R and B800B...
May 22, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28520339/reply-by-the-authors-re-artificial-urinary-sphincter-for-urinary-incontinence-after-radical-prostatectomy-a-historical-cohort-from-2004-to-2015
#2
Augusto Cesar Soares Dos Santos, Luíza de Oliveira Rodrigues, Daniela Castelo Azevedo, Lélia Maria de Almeida Carvalho, Mariana Ribeiro Fernandes, Sandra de Oliveira Sapori Avelar, Maria Glória Cruvinel Horta, Silvana Márcia Bruschi Kelles
No abstract text is available yet for this article.
May 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28507611/the-impact-of-extended-typing-on-red-blood-cell-alloimmunization-in-transfused-patients
#3
Tatjana Makarovska-Bojadzieva, Emilija Velkova, Milenka Blagoevska
BACKGROUND: Red blood cell (RBC) alloimmunization is still an actual problem in our transfusion practice. In 2011, in addition to the regular ABO/D blood group typing, phenotyping for Rh (C, c, E, e) and Kell antigens was introduced for blood donors and patients undergoing blood transfusion. Our aim was to evaluate the impact of the extended RBC typing and donor/recipient matching on the incidence of RBC alloimmunization. METHODS: A retrospective comparative study was conducted by reviewing RBC request records for about 36,000 patients transfused with RBC in the period from 2013 to 2015 in comparison to the similar study conducted on 47,000 transfused patients in the period from 2005 to 2008...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28492770/descriptive-study-on-the-evolution-of-hospitalization-costs-for-ambulatory-care-sensitive-conditions-in-brazil-2000-2013
#4
Dayane Kelle de Souza, Sérgio Viana Peixoto
OBJECTIVE: to analyze the proportions of costs of hospitalizations for ambulatory care sensitive conditions (ACSC) in relation to total hospitalization costs funded by the Brazilian National Health System (SUS) in Brazil, in 2000, 2005, 2010 and 2013, according to sex, age and group of causes. METHODS: this is a descriptive study, with data from SUS Hospital Information System (SIH/SUS); the proportion of hospitalization costs for ACSC was estimated in relation to total hospitalization costs...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28489892/exposure-to-maternal-obesogenic-diet-worsens-some-but-not-all-pre-cancer-phenotypes-in-a-murine-genetic-model-of-prostate-cancer
#5
Theresa Okeyo-Owuor, Emily Benesh, Scott Bibbey, Michaela Reid, Jacques Halabi, Siobhan Sutcliffe, Kelle Moley
Prostate cancer research has been predominantly focused on adult exposures and risk factors. However, because the prostate develops during gestation and early life, exposure to external factors, such as obesity, during development could affect the prostate cancer progression in adults. Our previous work demonstrated that exposure to a high fat/high sugar (HF/HS) diet during gestation and until weaning stimulated prostate hyperplasia and altered the Pten/Akt pathway in adult mice fed a normal diet after weaning...
2017: PloS One
https://www.readbyqxmd.com/read/28478703/a-bioreactor-to-identify-the-driving-mechanical-stimuli-of-tissue-growth-and-remodeling
#6
Mathieu A J van Kelle, Pim J A Oomen, Jurgen A Bulsink, Marloes W J T Janssen-van den Broek, Richard G P Lopata, Marcel Rutten, Sandra Loerakker, Carlijn Bouten
Tissue growth and remodeling are essential processes that should ensure long-term functionality of tissue engineered (TE) constructs. Even though it is widely recognized that these processes strongly depend on mechanical stimuli, the underlying mechanisms of mechanically-induced growth and remodeling are only partially understood. It is generally accepted that cells sense mechanical changes and respond by altering their surroundings, by means of extracellular matrix (ECM) growth and remodeling, in an attempt to return to a certain preferred mechanical homeostatic state...
May 6, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28466636/versatile-molecular-silver-ink-platform-for-printed-flexible-electronics
#7
Arnold J Kell, Chantal Paquet, Olga Mozenson, Iden Djavani-Tabrizi, Bhavana Deore, Xiangyang Liu, Gregory P Lopinski, Robert James, Khelifa Hettak, Jafar Shaker, Adrian Momciu, Julie Ferrigno, Olivier Ferrand, Jian Xiong Hu, Sylvie Lafrenière, Patrick R L Malenfant
A silver molecular ink platform formulated for screen, inkjet, and aerosol jet printing is presented. A simple formulation comprising silver neodecanoate, ethyl cellulose, and solvent provides improved performance versus that of established inks, yet with improved economics. Thin, screen-printed traces with exceptional electrical (<10 mΩ/□/mil or 12 μΩ·cm) and mechanical properties are achieved following thermal or photonic sintering, the latter having never been demonstrated for silver-salt-based inks...
May 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28459521/breast-cancer-stem-like-cells-can-promote-metastasis-by-activating-platelets-and-down-regulating-antitumor-activity-of-natural-killer-cells
#8
Shuo Wang, Ying Zhang, Weihong Cong, Jie Liu, Yuren Zhang, Huiting Fan, Yonggang Xu, Hongsheng Lin
OBJECTIVE: To investigate whether cancer stem cells (CSCs) more efficiently activating platelets and evading immune surveillance than non-CSCs thus promoting metastasis. METHODS: We enriched and identified sphere-forming cells (SFCs) and coincubated washed platelets with several platelet activators including collagen, 4T1 and SFCs. Platelet-coating tumor cells, platelet activation and TGF-β1 release were analyzed. Then natural kell cells (NK) were incubated with supernatants of different activated platelet samples what we called sample release (SR)...
August 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/28457201/how-are-sexual-health-clinics-in-england-managing-men-who-have-sex-with-men-who-refuse-to-be-tested-for-hiv
#9
Juan Hoyos Miller, Emily Clarke, Raj Patel, Philip Kell, Monica Desai, Anthony Nardone
The aim of this study was to ascertain the existence of written policies and common clinical practices in sexual health clinics in England for the management of men who have sex with men who refuse to test for HIV. All sexual health clinics in England ( n = 223) were invited to complete an online questionnaire in August-September 2014. The questionnaire covered the four domains of clinic policies, management practices, training and monitoring. We assess differences by region. Overall, 92 clinics participated...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28438607/obesity-exposed-oocytes-accumulate-and-transmit-damaged-mitochondria-due-to-an-inability-to-activate-mitophagy
#10
Anna L Boudoures, Jessica Saben, Andrea Drury, Suzanne Scheaffer, Zeel Modi, Wendy Zhang, Kelle H Moley
Mitochondria are the most prominent organelle in the oocyte. Somatic cells maintain a healthy population of mitochondria by degrading damaged mitochondria via mitophagy, a specialized autophagy pathway. However, evidence from previous work investigating the more general macroautophagy pathway in oocytes suggests that mitophagy may not be active in the oocyte. This would leave the vast numbers of mitochondria - poised to be inherited by the offspring - vulnerable to damage. Here we test the hypothesis that inactive mitophagy in the oocyte underlies maternal transmission of dysfunctional mitochondria...
April 21, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28438343/developmental-and-transmittable-origins-of-obesity-associated-health-disorders
#11
REVIEW
Arin K Oestreich, Kelle H Moley
The current global obesity pandemic is clearly linked to both the increasing prevalence of, and preference for, foods high in calories, specifically fat and sucrose, and declining levels of daily physical activity. A less commonly discussed possible explanation is that risk of obesity begins in utero as a result of developmental plasticity during early life. This idea fits into the broader Developmental Origins of Health and Diseases (DOHAD) hypothesis, which holds that stressful in utero exposure manifests as disease in adulthood...
April 21, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28432927/type-2-bvdv-n-pro-suppresses-ifn-1-pathway-signaling-in-bovine-cells-and-augments-brsv-replication
#12
Abdulrahman A Alkheraif, Christina L Topliff, Jay Reddy, Chandirasegaran Massilamany, Ruben O Donis, Gregor Meyers, Kent M Eskridge, Clayton L Kelling
Bovine viral diarrhea virus (BVDV) infection induces immunosuppression and in conjunction with bovine respiratory syncytial virus (BRSV) contributes to the bovine respiratory disease complex. Bovine turbinate cells were single or co-infected with type 2 BVDV wild-type (BVDV2-wt), its dysfunctional N(pro) mutant (BVDV2-E), and/or BRSV. BVDV2-E significantly up-regulated PKR, IRF-7, TBK-1, IRF-3, and IFN-β mRNAs based on real-time Q-RT-PCR. BRSV-infected cells expressed significantly up-regulated PKR, IRF-3, IRF-7, and IFN-β mRNAs, whereas BVDV2-wt, but not BVDV2-E, abolished this up-regulation in co-infection...
April 19, 2017: Virology
https://www.readbyqxmd.com/read/28416468/cardiac-transplantation-in-children-and-adolescents-with-long-qt-syndrome
#13
Angela M Kelle, J Martijn Bos, Susan P Etheridge, Bryan C Cannon, Randall M Bryant, Jonathan N Johnson, Michael J Ackerman
BACKGROUND: Long QT syndrome (LQTS) is a potentially lethal, yet highly treatable, cardiac channelopathy. Cardiac transplantation has been reported anecdotally for patients with severe LQTS refractory to standard therapies. OBJECTIVE: The purpose of this study was to evaluate the incidence of and risk factors for cardiac transplantation in children evaluated and treated in an LQTS specialty center. METHODS: This was a retrospective review of 349 children with LQTS (mean age at diagnosis, 8...
April 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28412163/electroencephalographic-responses-of-anaesthetized-pigs-sus-scrofa-to-tail-docking-using-clippers-or-cautery-iron-performed-at-2-or-20-days-of-age
#14
Nikki J Kells, Ngaio J Beausoleil, J Paul Chambers, Mhairi A Sutherland, Rebecca S Morrison, Craig B Johnson
OBJECTIVE: To compare electroencephalographic (EEG) responses of pigs to tail docking using clippers or cautery iron, performed at 2 or 20 days of age. STUDY DESIGN: Prospective, randomised controlled experimental study. ANIMALS: A total of 40 Large White x Landrace entire male pigs aged 2 (n=20) or 20 (n=20) days were randomly assigned to undergo tail docking using clippers or cautery iron. METHODS: Anaesthesia was induced and maintained with halothane delivered in oxygen...
February 24, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28411106/mass-spectrometry-imaging-shows-major-derangements-in-neurogranin-and-in-purine-metabolism-in-the-triple-knockout-3%C3%A3-tg-alzheimer-mouse-model
#15
Clara Esteve, Emrys A Jones, Douglas B Kell, Hervé Boutin, Liam A McDonnell
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) can simultaneously measure hundreds of biomolecules directly from tissue. Using different sample preparation strategies, proteins and metabolites have been profiled to study the molecular changes in a 3×Tg mouse model of Alzheimer's disease. In comparison with wild-type (WT) control mice MALDI-MSI revealed Alzheimer's disease-specific protein profiles, highlighting dramatic reductions of a protein with m/z 7560, which was assigned to neurogranin and validated by immunohistochemistry...
April 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28404097/hepatitis-b-and-hepatitis-c-in-southeast-and-southern-asia-challenges-for-governments
#16
Suzanne Wait, Emily Kell, Saeed Hamid, David H Muljono, Jose Sollano, Rosmawati Mohamed, Samir Shah, Mamun-Al-Mahtab, Zaigham Abbas, Jennifer Johnston, Tawesak Tanwandee, Jack Wallace
In 2015, the Coalition to Eradicate Viral Hepatitis in Asia Pacific gathered leading hepatitis experts from Bangladesh, India, Indonesia, Malaysia, Pakistan, the Philippines, and Thailand to discuss common challenges to the burden posed by hepatitis B virus (HBV) and hepatitis C virus (HCV), to learn from each other's experience, and identify sustainable approaches. In this report, we summarise these discussions. Countries differ in their policy responses to HBV and HCV; however, substantial systemic, cultural, and financial barriers to achievement of elimination of these infections persist in all countries...
November 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28396636/enhancing-drug-efficacy-and-therapeutic-index-through-cheminformatics-based-selection-of-small-molecule-binary-weapons-that-improve-transporter-mediated-targeting-a-cytotoxicity-system-based-on-gemcitabine
#17
Justine M Grixti, Steve O'Hagan, Philip J Day, Douglas B Kell
The transport of drug molecules is mainly determined by the distribution of influx and efflux transporters for which they are substrates. To enable tissue targeting, we sought to develop the idea that we might affect the transporter-mediated disposition of small-molecule drugs via the addition of a second small molecule that of itself had no inhibitory pharmacological effect but that influenced the expression of transporters for the primary drug. We refer to this as a "binary weapon" strategy. The experimental system tested the ability of a molecule that on its own had no cytotoxic effect to increase the toxicity of the nucleoside analog gemcitabine to Panc1 pancreatic cancer cells...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28394609/toward-an-understanding-of-the-excitonic-structure-of-the-cp47-antenna-protein-complex-of-photosystem-ii-revealed-via-circularly-polarized-luminescence
#18
Mahboobe Jassas, Tonu Reinot, Adam Kell, Ryszard Jankowiak
Identification of the lowest energy pigments in the photosynthetic CP47 antenna protein complex of Photosystem II (PSII) is essential for understanding its excitonic structure, as well as excitation energy pathways in the PSII core complex. Unfortunately, there is no consensus concerning the nature of the low-energy state(s), nor chlorophyll (Chl) site energies in this important photosynthetic antenna. Although we raised concerns regarding the estimations of Chl site energies obtained from modeling studies of various types of CP47 optical spectra [Reinot, T; et al...
May 4, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28392952/clinical-implications-for-the-timely-diagnosis-of-mycobacterium-marinum-in-the-age-of-biologic-therapy-a-case-report-and-review-of-the-literature
#19
Chris J Lata, Kelle Edgar, Stephen Vaughan
Mycobacterium marinum infections typically present as cutaneous nodular lesions with a sporotrichoid lymphatic spread on extensor surfaces of extremities. The natural history of this infection can be altered if the host is immunosuppressed, leading to disseminated presentations. A detailed exposure history and high degree of suspicion for this indolent pathogen are often required for the correct diagnosis of this disease. We present a case of a 67-year-old male misdiagnosed with seronegative rheumatoid arthritis presenting with rheumatic nodules...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28357148/anti-k1-kell-antibody-expressed-in-maternal-breastmilk-a-case-report-of-a-neonate-with-multiple-intrauterine-transfusions-and-postnatal-exposure-to-kell-antibody-in-maternal-breastmilk
#20
Patrick DeMoss, Mohamed Asfour, Kelly Hersey
Hemolytic disease of the fetus and newborn is a common consideration in newborn medicine, especially among the jaundiced. Maternal breastmilk provides numerous benefits to the infant, including nutrition and immunologic factors. Here, we present an infant who received three intrauterine transfusions for anemia secondary to anti-K1 (Kell), anti-C, and anti-e antibodies and whose maternal breastmilk tested positive for anti-Kell antibodies. The infant required another transfusion at 4 weeks of life for anemia...
2017: Case Reports in Pediatrics
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