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https://www.readbyqxmd.com/read/29143708/genome-wide-association-study-for-growth-traits-in-nelore-cattle
#1
A P N Terakado, R B Costa, G M F de Camargo, N Irano, T Bresolin, L Takada, C V D Carvalho, H N Oliveira, R Carvalheiro, F Baldi, L G de Albuquerque
The objective of this study was to investigate the association of single nucleotide polymorphisms (SNPs) with birth weight, weight gain from birth to weaning and from weaning to yearling, yearling height and cow weight in Nelore cattle. Data from 5064 animals participating in the DeltaGen and PAINT breeding programs were used. The animals were genotyped with a panel of 777 962 SNPs (Illumina BovineHD BeadChip) and 412 993 SNPs remained after quality control analysis of the genomic data. A genome-wide association study was performed using a single-step methodology...
November 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29142193/pten-is-a-protein-phosphatase-that-targets-active-ptk6-and-inhibits-ptk6-oncogenic-signaling-in-prostate-cancer
#2
Darren J Wozniak, Andre Kajdacsy-Balla, Virgilia Macias, Susan Ball-Kell, Morgan L Zenner, Wenjun Bie, Angela L Tyner
PTEN activity is often lost in prostate cancer. We show that the tyrosine kinase PTK6 (BRK) is a PTEN substrate. Phosphorylation of PTK6 tyrosine 342 (PY342) promotes activation, while phosphorylation of tyrosine 447 (PY447) regulates auto-inhibition. Introduction of PTEN into a PTEN null prostate cancer cell line leads to dephosphorylation of PY342 but not PY447 and PTK6 inhibition. Conversely, PTEN knockdown promotes PTK6 activation in PTEN positive cells. Using a variety of PTEN mutant constructs, we show that protein phosphatase activity of PTEN targets PTK6, with efficiency similar to PTP1B, a phosphatase that directly dephosphorylates PTK6 Y342...
November 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29134633/first-in-human-study-with-the-inhaled-tlr9-oligonucleotide-agonist-azd1419-results-in-interferon-responses-in-the-lung-and-is-safe-and-well-tolerated
#3
Sam Jackson, Albert F Candia, Stephen Delaney, Simone Floettmann, Clifford Wong, John D Campbell, Sariah Kell, Jeremy Lum, Edith Hessel, Paula Traquina, Mark McHale, Ian Robinson, John Bell, Rainard Fuhr, David Keeling, Robert L Coffman
Current asthma treatments address symptoms rather than the underlying disease pathophysiology, a better understanding of which has led to the identification of the Th2 high endotype. The activation of Toll-like receptors to induce Type I interferons directly in the lungs represents a novel therapeutic approach to reset this underlying Th2 pathophysiology with the potential to provide long-term disease modification. We present the nonclinical data and phase 1 clinical profile of an inhaled TLR9 agonist, AZD1419, a C-type CpG designed to induce interferon in the lung...
November 14, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29127402/the-nature-of-ancient-egyptian-copper-containing-carbon-inks-is-revealed-by-synchrotron-radiation-based-x-ray-microscopy
#4
Thomas Christiansen, Marine Cotte, René Loredo-Portales, Poul Erik Lindelof, Kell Mortensen, Kim Ryholt, Sine Larsen
For the first time it is shown that carbon black inks on ancient Egyptian papyri from different time periods and geographical regions contain copper. The inks have been investigated using synchrotron-based micro X-ray fluorescence (XRF) and micro X-ray absorption near-edge structure spectroscopy (XANES) at the European Synchrotron Radiation Facility (ESRF). The composition of the copper-containing carbon inks showed no significant differences that could be related to time periods or the geographical locations...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29125875/drug-abusers-have-impaired-cerebral-oxygenation-and-cognition-during-exercise
#5
Kell Grandjean da Costa, Vanessa Soares Rachetti, Weslley Quirino Alves da Silva, Daniel Aranha Rego Cabral, Daniel Gomes da Silva Machado, Eduardo Caldas Costa, Rodrigo Menezes Forti, Rickson Coelho Mesquita, Hassan Mohamed Elsangedy, Alexandre Hideki Okano, Eduardo Bodnariuc Fontes
BACKGROUND: Individuals with Substance Use Disorder (SUD) have lower baseline metabolic activity of the prefrontal cortex (PFC) associated with impairment of cognitive functions in decision-making and inhibitory control. Aerobic exercise has shown to improve PFC function and cognitive performance, however, its effects on SUD individuals remain unclear. PURPOSE: To verify the cognitive performance and oxygenation of the PFC during an incremental exercise in SUD individuals...
2017: PloS One
https://www.readbyqxmd.com/read/29116868/a-multiple-group-measurement-scale-for-interprofessional-collaboration-adaptation-and-validation-into-italian-and-german-languages
#6
Fabio Vittadello, Maria Mischo-Kelling, Heike Wieser, Luisa Cavada, Lukas Lochner, Carla Naletto, Verena Fink, Scott Reeves
This article presents a study that aimed to validate a translation of a multiple-group measurement scale for interprofessional collaboration (IPC). We used survey data gathered over a three month period as part of a mixed methods study that explored the nature of IPC in Northern Italy. Following a translation from English into Italian and German the survey was distributed online to over 5,000 health professionals (dieticians, nurses, occupational therapists, physicians, physiotherapists, speech therapists and psychologists) based in one regional health trust...
November 8, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29102975/fatal-delayed-haemolytic-transfusion-reaction-in-a-patient-without-previous-transfusions-but-with-an-obstetric-history-of-13-pregnancies
#7
Evgeni Chubar, Naiel Bisharat
Delayed haemolytic transfusion reaction is a rare, life-threatening complication of blood transfusion that has been typically described among patients with sickle cell disease (SCD) due to alloimmunisation induced by their exposure to red blood cell antigens through recurrent transfusions. We report the case of a patient who suffered from fatal delayed haemolytic transfusion reaction (DHTR) occurring 1 week after blood transfusion. Indirect antiglobulin testing confirmed the presence of anti-Kell antibodies that were absent in the pretransfusion sample...
November 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29096623/substantial-fibrin-amyloidogenesis-in-type-2-diabetes-assessed-using-amyloid-selective-fluorescent-stains
#8
Etheresia Pretorius, Martin J Page, Lize Engelbrecht, Graham C Ellis, Douglas B Kell
BACKGROUND: We have previously shown that many chronic, inflammatory diseases are accompanied, and possibly partly caused or exacerbated, by various coagulopathies, manifested as anomalous clots in the form of 'dense matted deposits'. More recently, we have shown that these clots can be amyloid in nature, and that the plasma of healthy controls can be induced to form such clots by the addition of tiny amounts of bacterial lipopolysaccharide or lipoteichoic acid. Type 2 diabetes (T2D) is also accompanied by raised levels of LPS...
November 2, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29092879/eggs-early-in-complementary-feeding-increase-choline-pathway-biomarkers-and-dha-a-randomized-controlled-trial-in-ecuador
#9
Lora L Iannotti, Chessa K Lutter, William F Waters, Carlos Andres Gallegos Riofrío, Carla Malo, Gregory Reinhart, Ana Palacios, Celia Karp, Melissa Chapnick, Katherine Cox, Santiago Aguirre, Luis Narvaez, Fernando López, Rohini Sidhu, Pamela Kell, Xuntian Jiang, Hideji Fujiwara, Daniel S Ory, Rebecca Young, Christine P Stewart
Background: Choline status has been associated with stunting among young children. Findings from this study showed that an egg intervention improved linear growth by a length-for-age z score of 0.63.Objective: We aimed to test the efficacy of eggs introduced early in complementary feeding on plasma concentrations of biomarkers in choline pathways, vitamins B-12 and A, and essential fatty acids.Design: A randomized controlled trial, the Lulun ("egg" in Kichwa) Project, was conducted in a rural indigenous population of Ecuador...
November 1, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29090640/listening-into-2030-workshop-an-experiment-in-envisioning-the-future-of-hearing-and-communication-science
#10
Simon Carlile, Gregory Ciccarelli, Jane Cockburn, Anna C Diedesch, Megan K Finnegan, Ervin Hafter, Simon Henin, Sridhar Kalluri, Alexander J E Kell, Erol J Ozmeral, Casey L Roark, Jessica E Sagers
Here we report the methods and output of a workshop examining possible futures of speech and hearing science out to 2030. Using a design thinking approach, a range of human-centered problems in communication were identified that could provide the motivation for a wide range of research. Nine main research programs were distilled and are summarized: (a) measuring brain and other physiological parameters, (b) auditory and multimodal displays of information, (c) auditory scene analysis, (d) enabling and understanding shared auditory virtual spaces, (e) holistic approaches to health management and hearing impairment, (f) universal access to evolving and individualized technologies, (g) biological intervention for hearing dysfunction, (h) understanding the psychosocial interactions with technology and other humans as mediated by technology, and (i) the impact of changing models of security and privacy...
January 2017: Trends in Hearing
https://www.readbyqxmd.com/read/29090447/adaptation-in-toxic-environments-comparative-genomics-of-loci-carrying-antibiotic-resistance-genes-derived-from-acid-mine-drainage-waters
#11
Florence Arsène-Ploetze, Olfa Chiboub, Didier Lièvremont, Julien Farasin, Kelle C Freel, Stephanie Fouteau, Valérie Barbe
Several studies have suggested the existence of a close relationship between antibiotic-resistant phenotypes and resistance to other toxic compounds such as heavy metals, which involve co-resistance or cross-resistance mechanisms. A metagenomic library was previously constructed in Escherichia coli with DNA extracted from the bacterial community inhabiting an acid mine drainage (AMD) site highly contaminated with heavy metals. Here, we conducted a search for genes involved in antibiotic resistance using this previously constructed library...
October 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29072458/coordination-and-insertion-competitive-channels-for-borylene-reactions
#12
Kelling J Donald, Ezana Befekadu, Supreeth Prasad
Monovalent boron, free borylene species of the form B-R are notoriously unstable. Consequently, there are substantial gaps in the literature concerning the potential utility of those species in organic and inorganic synthesis either as ligands or as critical intermediates in reactions. We show that the relative stability of borylene complexes varies widely, depending on the electron donating ability of the R group. We find that borylenes can form, in the gas phase, weak sigma hole type interactions to saturated carbon centers and stronger dative bonds to tetravalent silicon and germanium...
November 9, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29062953/synbiochem-synthetic-biology-research-centre-manchester-a-uk-foundry-for-fine-and-speciality-chemicals-production
#13
Le Feuvre Ra, Carbonell P, Currin A, Dunstan M, Fellows D, Jervis Aj, Rattray Njw, Robinson Cj, Swainston N, Vinaixa M, Williams A, Yan C, Barran P, Breitling R, Chen Gg, Faulon Jl, Goble C, Goodacre R, Kell Db, Micklefield J, Scrutton Ns, Shapira P, Takano E, Turner Nj
The UK Synthetic Biology Research Centre, SYNBIOCHEM, hosted by the Manchester Institute of Biotechnology at the University of Manchester is delivering innovative technology platforms to facilitate the predictable engineering of microbial bio-factories for fine and speciality chemicals production. We provide an overview of our foundry activities that are being applied to grand challenge projects to deliver innovation in bio-based chemicals production for industrial biotechnology.
December 2016: Synthetic and Systems Biotechnology
https://www.readbyqxmd.com/read/29062250/hyperbilirubinemia-due-to-minor-blood-group-anti-e-incompatibility-in-a-newborn-a-case-report
#14
Murat Özcan, Selin Sevinç, Vildan Boz Erkan, Yüksel Yurdugül, S Ümit Sarıcı
In addition to Rh and ABO incompatibilities subgroup incompatibilities may rarely play a role among the causes of hemolytic anemia and indirect hyperbilirubinemia in newborns. The most common minor blood group antigens that cause blood incompatibility between the mother and baby are C, c, E, e, Kell, Duffy, Diego, Kidd and MNSs antigens. In this article, a newborn in whom hyperbilirubinemia due to anti-E minor blood group incompatibility developed and was treated with phototherapy succesfully is presented and minor blood group incompatibilities due to anti-E are reviewed...
September 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/29059525/dynamic-histogram-analysis-to-determine-free-energies-and-rates-from-biased-simulations
#15
Lukas S Stelzl, Adam Kells, Edina Rosta, Gerhard Hummer
We present an algorithm to calculate free energies and rates from molecular simulations on biased potential energy surfaces. As input, it uses the accumulated times spent in each state or bin of a histogram, and counts of transitions between them. Optimal unbiased equilibrium free energies for each of the states/bins are then obtained by maximizing the likelihood of a master equation (i.e., first-order kinetic rate model). The resulting free energies also determine the optimal rate coefficients for transitions between the states or bins on the biased potentials...
October 23, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29055328/peptide-dimerization-dissociation-rates-from-replica-exchange-molecular-dynamics
#16
Cathal T Leahy, Adam Kells, Gerhard Hummer, Nicolae-Viorel Buchete, Edina Rosta
We show how accurate rates of formation and dissociation of peptide dimers can be calculated using direct transition counting (DTC) from replica-exchange molecular dynamics (REMD) simulations. First, continuous trajectories corresponding to system replicas evolving at different temperatures are used to assign conformational states. Second, we analyze the entire REMD data to calculate the corresponding rates at each temperature directly from the number of transition counts. Finally, we compare the kinetics extracted directly, using the DTC method, with indirect estimations based on trajectory likelihood maximization using short-time propagators and on decay rates of state autocorrelation functions...
October 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29043830/red-blood-cell-phenotype-prevalence-in-blood-donors-who-self-identify-as-hispanic
#17
Chelsea A Sheppard, Nicole L Bolen, Beth Eades, Gorka Ochoa-Garay, Mark H Yazer
Molecular genotyping platforms provide a quick, high-throughput method for identifying red blood cell units for patients on extended phenotype-matching protocols, such as those with sickle cell disease or thalassemia. Most of the antigen prevalence data reported are for non-Hispanic populations. Therefore, this study sought to determine the phenotype prevalence in a single blood center's Hispanic population and to compare those results with previously reported rates in non-Hispanic donor populations. We performed a retrospective review of all serologic and molecular typing from donors who self-reported as Hispanic...
September 2017: Immunohematology
https://www.readbyqxmd.com/read/29042259/widespread-optogenetic-expression-in-macaque-cortex-obtained-with-mr-guided-convection-enhanced-delivery-ced-of-aav-vector-to-the-thalamus
#18
Azadeh Yazdan-Shahmorad, Nan Tian, Viktor Kharazia, Lluis Samaranch, Adrian Kells, John Bringas, Jiwei He, Krystof Bankiewicz, Philip N Sabes
BACKGROUND: In non-human primate (NHP) optogenetics, infecting large cortical areas with viral vectors is often a difficult and time-consuming task. Previous work has shown that parenchymal delivery of adeno-associated virus (AAV) in the thalamus by convection-enhanced delivery (CED) can lead to large-scale transduction via axonal transport in distal areas including cortex. We used this approach to obtain widespread cortical expression of light-sensitive ion channels. NEW METHOD: AAV vectors co-expressing channelrhodopsin-2 (ChR2) and yellow fluorescent protein (YFP) genes were infused into thalamus of three rhesus macaques under MR-guided CED...
October 16, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29037798/electroencephalographic-assessment-of-oral-meloxicam-topical-anaesthetic-cream-and-cautery-iron-for-mitigating-acute-pain-in-pigs-sus-scrofa-undergoing-tail-docking
#19
Nikki J Kells, N J Beausoleil, M A Sutherland, R M Morrison, Craig B Johnson
OBJECTIVE: To evaluate the efficacy of oral meloxicam, topical anaesthetic cream and cautery iron in mitigating acute nociceptive responses of pigs to tail docking. STUDY DESIGN: A prospective, randomized, controlled experimental study. ANIMALS: A total of 40 healthy Large WhitexLandrace pigs aged 21±1 days, weighing 6.1±0.9 kg. METHODS: Pigs were randomly assigned to one of four treatments (n=10 per treatment): CONTROL: docked using clippers without analgesia; MEL: docked using clippers after administration of oral meloxicam; EMLA: docked using clippers after application of topical anaesthetic cream; and CAUT: docked using a cautery iron without analgesia...
February 24, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29037318/coexistence-of-hypertrophic-osteoarthropathy-and-myelofibrosis
#20
Bayram Kelle, Fatih Yıldız, Semra Paydas, Emine Kılıc Bagır, Melek Ergin, Erkan Kozanoglu
No abstract text is available yet for this article.
September 2017: Revista Brasileira de Reumatologia
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