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https://www.readbyqxmd.com/read/28097704/prophylactic-rhce-and-kell-antigen-matching-impact-on-alloimmunization-in-transfusion-dependent-patients-with-myelodysplastic-syndromes
#1
Y Lin, A Saskin, R A Wells, M Lenis, A Mamedov, J Callum, R Buckstein
BACKGROUND AND OBJECTIVES: Thirty to 80 per cent of patients with myelodysplastic syndromes (MDS) become transfusion-dependent and are at risk for red blood cell (RBC) alloimmunization. This study compared alloimmunization rates in transfusion-dependent patients with MDS at an institution with a policy of prophylactic antigen matching for RhCE and K (PAM) with those transfused at institutions without such a policy (non-PAM). MATERIALS AND METHODS: Transfusion records were retrospectively reviewed to determine total number of RBC transfusions received, whether RBC phenotyping was performed, the type and date of first alloantibody development and receipt of prophylactic antigen matching for RhCE and K...
January 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28040400/emerging-strategies-of-blood-group-genotyping-for-patients-with-hemoglobinopathies
#2
REVIEW
A Belsito, K Magnussen, C Napoli
Red cell alloimmunization is a serious problem in chronically transfused patients. A number of high-throughput DNA assays have been developed to extend or replace traditional serologic antigen typing. DNA-based typing methods may be easily automated and multiplexed, and provide reliable information on a patient. Molecular genotyping promises to become cheaper, being not dependent on serologic immunoglobulin reagents. Patients with hemoglobinopathies could benefit from receiving extended genomic typing. This could limit post transfusional complications depending on subtle antigenic differences between donors and patients...
December 9, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28038786/epidemiologic-data-of-trauma-related-lower-limb-amputees-a-single-center-10-year-experience
#3
Evren Yaşar, Fatih Tok, Serdar Kesikburun, A Mustafa Ada, Bayram Kelle, A Salim Göktepe, Kamil Yazıcıoğlu, A Kenan Tan
OBJECTIVE: The aim of this study is three fold: 1) to introduce epidemiologic data of patients with trauma-related amputations as a 10-year experience of a rehabitation center; 2) to determine comorbidities and secondary conditions of lower limb loss; 3) to determine the rehospitalization reasons for lower limb amputee patients. MATERIALS AND METHODS: This retrospective study was conducted in a tertiary rehabilitation center in Turkey. Clinical and demographic data of amputees including sex, age, employment status, time since amputation, time after amputation to first hospitalization, length of hospitalization, how many times the patient was hospitalized, reason for hospitalization, stump complications, comorbid conditions, amputation level and K classifacation were documented...
December 23, 2016: Injury
https://www.readbyqxmd.com/read/28028036/reduced-islet-function-contributes-to-impaired-glucose-homeostasis-in-fructose-fed-mice
#4
Zeenat A Asghar, Andrew Cusumano, Zihan Yan, Maria S Remedi, Kelle H Moley
Increased sugar consumption, particularly fructose, in the form of sweetened beverages and sweeteners in our diet adversely affects metabolic health. Because these effects are associated with features of the metabolic syndrome in humans, the direct effect of fructose on pancreatic islet function is unknown. We therefore examined the islet phenotype of mice fed excess fructose. Fructose-fed mice exhibited fasting hyperglycemia and glucose intolerance, but not hyperinsulinemia, dyslipidemia, or hyperuricemia...
December 27, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28012565/healthcare-utilization-for-arthritis-by-indigenous-populations-of-australia-canada-new-zealand-and-the-united-states-a-systematic-review-%C3%A2
#5
REVIEW
Adalberto Loyola-Sanchez, Kelle Hurd, Cheryl Barnabe
PURPOSE: Indigenous populations of Australia, Canada, New Zealand, and the United States of America (USA) experience a higher prevalence of arthritis conditions. Differences in clinical outcomes and mortality may reflect healthcare service use inequities. The objective of this study was to summarize healthcare service use patterns described in the existing literature in order to identify gaps and inform strategies to limit the pronounced negative impact of arthritis on Indigenous populations...
November 1, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28011593/an-informatics-based-approach-to-reducing-heart-failure-all-cause-readmissions-the-stanford-heart-failure-dashboard
#6
Dipanjan Banerjee, Christine Thompson, Charlene Kell, Rajesh Shetty, Yohan Vetteth, Helene Grossman, Aria DiBiase, Michael Fowler
BACKGROUND: Reduction of 30-day all-cause readmissions for heart failure (HF) has become an important quality-of-care metric for health care systems. Many hospitals have implemented quality improvement programs designed to reduce 30-day all-cause readmissions for HF. Electronic medical record (EMR)-based measures have been employed to aid in these efforts, but their use has been largely adjunctive to, rather than integrated with, the overall effort. OBJECTIVES: We hypothesized that a comprehensive EMR-based approach utilizing an HF dashboard in addition to an established HF readmission reduction program would further reduce 30-day all-cause index hospital readmission rates for HF...
December 23, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27988789/systematic-review-of-rheumatic-disease-phenotypes-and-outcomes-in-the-indigenous-populations-of-canada-the-usa-australia-and-new-zealand
#7
REVIEW
Kelle Hurd, Cheryl Barnabe
We performed a systematic review designed to characterize clinical phenotypes and outcomes in Indigenous populations with rheumatic disease to enhance the understanding of how rheumatic disease presents in Indigenous populations and allow for better projection of the healthcare needs of the communities affected. A systematic search was performed in medical (Medline, EMBASE, CINAHL), Indigenous and conference abstract databases (to June 2015). Search terms for Indigenous populations were combined with terms for inflammatory arthritis conditions, connective tissue disorders, crystal arthritis and osteoarthritis...
December 17, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27988005/corrigendum-to-plant-crafted-starches-for-bioplastics-production-carbohydr-polym-152-2016-398-408
#8
Domenico Sagnelli, Kim H Hebelstrup, Eric Leroy, Agnès Rolland-Sabaté, Sophie Guilois, Jacob J K Kirkensgaard, Kell Mortensen, Denis Lourdin, Andreas Blennow
No abstract text is available yet for this article.
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27980845/crystal-structures-of-three-bicyclic-carbohydrate-derivatives
#9
Uwe Schilde, Alexandra Kelling, Sumaira Umbreen, Torsten Linker
The title compounds, [(1R,3R,4R,5R,6S)-4,5-bis-(acet-yloxy)-7-oxo-2-oxabi-cyclo[4.2.0]octan-3-yl]methyl acetate, C14H18O8, (I), [(1S,4R,5S,6R)-5-acet-yloxy-7-hy-droxy-imino-2-oxobi-cyclo-[4.2.0]octan-4-yl acetate, C11H15NO6, (II), and [(3aR,5R,6R,7R,7aS)-6,7-bis-(acet-yloxy)-2-oxo-octa-hydro-pyrano[3,2-b]pyrrol-5-yl]methyl acetate, C14H19NO8, (III), are stable bicyclic carbohydrate derivatives. They can easily be synthesized in a few steps from commercially available glycals. As a result of the ring strain from the four-membered rings in (I) and (II), the conformations of the carbohydrates deviate strongly from the ideal chair form...
December 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27973779/concatemers-of-outer-membrane-protein-a-take-detours-in-the-folding-landscape
#10
Kell K Andersen, Brian Vad, Sahar Omer, Daniel E Otzen
Outer membrane protein A (OmpA) is the most abundant protein in the outer membrane of Escherichia coli. The N-terminal domain forms an eight-stranded membrane-embedded β-barrel that is widely used as a model protein for in vitro folding into the membrane and into surfactant micelles. Under conditions that include a low surfactant concentration, OmpA can form stable higher-order structures by intermolecular association. Other β-barrel membrane proteins also associate to form noncovalently linked trimers in vivo...
December 27, 2016: Biochemistry
https://www.readbyqxmd.com/read/27965958/a-dormant-microbial-component-in-the-development-of-preeclampsia
#11
REVIEW
Douglas B Kell, Louise C Kenny
Preeclampsia (PE) is a complex, multisystem disorder that remains a leading cause of morbidity and mortality in pregnancy. Four main classes of dysregulation accompany PE and are widely considered to contribute to its severity. These are abnormal trophoblast invasion of the placenta, anti-angiogenic responses, oxidative stress, and inflammation. What is lacking, however, is an explanation of how these themselves are caused. We here develop the unifying idea, and the considerable evidence for it, that the originating cause of PE (and of the four classes of dysregulation) is, in fact, microbial infection, that most such microbes are dormant and hence resist detection by conventional (replication-dependent) microbiology, and that by occasional resuscitation and growth it is they that are responsible for all the observable sequelae, including the continuing, chronic inflammation...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27940969/david-kells-o-donel-calderwood
#12
Sandra Calderwood, Robin Calderwood
No abstract text is available yet for this article.
December 9, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27931094/human-lysozyme-peptidase-resistance-is-perturbed-by-the-anionic-glycolipid-biosurfactant-rhamnolipid-produced-by-the-opportunistic-pathogen-pseudomonas-aeruginosa
#13
Kell K Andersen, Brian S Vad, Carsten Scavenius, Jan J Enghild, Daniel E Otzen
Infection by the opportunistic pathogen Pseudomonas aeruginosa (PA) is accompanied by the secretion of virulence factors such as the secondary metabolite rhamnolipid (RL) as well as an array of bacterial enzymes, including the peptidase elastase. The human immune system tries to counter this via defensive proteins such as lysozyme (HLZ). HLZ targets the bacterial cell wall but may also have other antimicrobial activities. The enzyme contains four disulfide bonds and shows high thermodynamic stability and resistance to proteolytic attack...
December 20, 2016: Biochemistry
https://www.readbyqxmd.com/read/27927805/transmission-of-metabolic-dysfunction-across-generations
#14
REVIEW
Kathleen Jaeger, Jessica L Saben, Kelle H Moley
Recent human and animal studies investigating the roles of the genome, epigenome, and environmental cues have identified associations between offspring predisposition to life-long obesity/metabolic disease and epigenetic modifications such as DNA methylation. This review explores the mechanisms by which maternal exposures impair the health of not only the next generation but also potentially future generations of offspring.
January 2017: Physiology
https://www.readbyqxmd.com/read/27923106/for-the-love-of-a-son-and-father-the-price-we-pay
#15
Kelle L Brogan
No abstract text is available yet for this article.
December 6, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27914688/systematic-review-of-rheumatic-disease-epidemiology-in-the-indigenous-populations-of-canada-the-united-states-australia-and-new-zealand
#16
REVIEW
Cairistin McDougall, Kelle Hurd, Cheryl Barnabe
OBJECTIVE: Past publications have highlighted an excess rheumatic disease incidence and prevalence in indigenous populations of Canada (First Nations, Inuit, and Métis), and the United States of America (Alaska Native and American Indian). We have updated these reviews and expanded the scope to include New Zealand (Maori) and Australia (Aborigine) indigenous populations. METHODS: We performed a broad search using medical literature databases, indigenous specific online indexes, and government websites to identify publications reporting the incidence and/or prevalence of arthritis conditions (rheumatoid arthritis, spondyloarthropathies, gout, osteoarthritis, systemic autoimmune rheumatic diseases, and juvenile idiopathic arthritis) in the indigenous populations of Canada, America, New Zealand, and Australia...
November 1, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27903311/comparison-of-neural-histomorphology-in-tail-tips-from-pigs-docked-using-clippers-or-cautery-iron
#17
N J Kells, N J Beausoleil, C B Johnson, M A Sutherland, R S Morrison, W Roe
Tail docking of pigs is commonly performed to reduce the incidence of unwanted tail-biting behaviour. Two docking methods are commonly used: blunt trauma cutting (i.e. using side clippers), or cutting and concurrent cauterisation using a hot cautery iron. A potential consequence of tail amputation is the development of neuromas at the docking site. Neuromas have been linked to neuropathic pain, which can influence the longer-term welfare of affected individuals. To determine whether method of tail docking influences the extent of neuroma formation, 75 pigs were allocated to one of three treatments at birth: tail docked using clippers; tail docked using cautery iron; tail left intact...
December 1, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27889698/major-involvement-of-bacterial-components-in-rheumatoid-arthritis-and-its-accompanying-oxidative-stress-systemic-inflammation-and-hypercoagulability
#18
Etheresia Pretorius, Oore-Ofe Akeredolu, Prashilla Soma, Douglas B Kell
We review the evidence that infectious agents, including those that become dormant within the host, have a major role to play in much of the etiology of rheumatoid arthritis and the inflammation that is its hallmark. This occurs in particular because they can produce cross-reactive (auto-)antigens, as well as potent inflammagens such as lipopolysaccharide that can themselves catalyze further inflammagenesis, including via β-amyloid formation. A series of observables coexist in many chronic, inflammatory diseases as well as rheumatoid arthritis...
November 25, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27880836/towards-the-automatic-classification-of-avian-flight-calls-for-bioacoustic-monitoring
#19
Justin Salamon, Juan Pablo Bello, Andrew Farnsworth, Matt Robbins, Sara Keen, Holger Klinck, Steve Kelling
Automatic classification of animal vocalizations has great potential to enhance the monitoring of species movements and behaviors. This is particularly true for monitoring nocturnal bird migration, where automated classification of migrants' flight calls could yield new biological insights and conservation applications for birds that vocalize during migration. In this paper we investigate the automatic classification of bird species from flight calls, and in particular the relationship between two different problem formulations commonly found in the literature: classifying a short clip containing one of a fixed set of known species (N-class problem) and the continuous monitoring problem, the latter of which is relevant to migration monitoring...
2016: PloS One
https://www.readbyqxmd.com/read/27879519/use-of-the-wattbike-cycle-ergometer-for-attenuation-of-bilateral-pedaling-asymmetry-in-trained-cyclists
#20
David T Kell, Beau Kjerulf Greer
Experienced cyclists typically pedal with a 5-20% bilateral asymmetry in regards to power output. The aim of this study was to determine if visual feedback via the Wattbike cycle ergometer is an effective tool in reducing bilateral pedaling asymmetry in trained cyclists. Twelve subjects completed three 10-minute cycling trials on the Wattbike at a power output consistent with 60% VO2 peak. The three trials consisted of a baseline (BASE) trial in which cyclists pedaled without instruction, a conscious control (CC) trial during which cyclists attempted to pedal symmetrically, and another trial in which cyclists attempted to pedal symmetrically while utilizing visual feedback (VF) of their bilateral power outputs (%) via the Wattbike...
May 19, 2016: Journal of Strength and Conditioning Research
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