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https://www.readbyqxmd.com/read/27923106/for-the-love-of-a-son-and-father-the-price-we-pay
#1
Kelle L Brogan
No abstract text is available yet for this article.
December 6, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27914688/systematic-review-of-rheumatic-disease-epidemiology-in-the-indigenous-populations-of-canada-the-united-states-australia-and-new-zealand
#2
REVIEW
Cairistin McDougall, Kelle Hurd, Cheryl Barnabe
OBJECTIVE: Past publications have highlighted an excess rheumatic disease incidence and prevalence in indigenous populations of Canada (First Nations, Inuit, and Métis), and the United States of America (Alaska Native and American Indian). We have updated these reviews and expanded the scope to include New Zealand (Maori) and Australia (Aborigine) indigenous populations. METHODS: We performed a broad search using medical literature databases, indigenous specific online indexes, and government websites to identify publications reporting the incidence and/or prevalence of arthritis conditions (rheumatoid arthritis, spondyloarthropathies, gout, osteoarthritis, systemic autoimmune rheumatic diseases, and juvenile idiopathic arthritis) in the indigenous populations of Canada, America, New Zealand, and Australia...
November 1, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27903311/comparison-of-neural-histomorphology-in-tail-tips-from-pigs-docked-using-clippers-or-cautery-iron
#3
N J Kells, N J Beausoleil, C B Johnson, M A Sutherland, R S Morrison, W Roe
Tail docking of pigs is commonly performed to reduce the incidence of unwanted tail-biting behaviour. Two docking methods are commonly used: blunt trauma cutting (i.e. using side clippers), or cutting and concurrent cauterisation using a hot cautery iron. A potential consequence of tail amputation is the development of neuromas at the docking site. Neuromas have been linked to neuropathic pain, which can influence the longer-term welfare of affected individuals. To determine whether method of tail docking influences the extent of neuroma formation, 75 pigs were allocated to one of three treatments at birth: tail docked using clippers; tail docked using cautery iron; tail left intact...
December 1, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27889698/major-involvement-of-bacterial-components-in-rheumatoid-arthritis-and-its-accompanying-oxidative-stress-systemic-inflammation-and-hypercoagulability
#4
Etheresia Pretorius, Oore-Ofe Akeredolu, Prashilla Soma, Douglas B Kell
We review the evidence that infectious agents, including those that become dormant within the host, have a major role to play in much of the etiology of rheumatoid arthritis and the inflammation that is its hallmark. This occurs in particular because they can produce cross-reactive (auto-)antigens, as well as potent inflammagens such as lipopolysaccharide that can themselves catalyze further inflammagenesis, including via β-amyloid formation. A series of observables coexist in many chronic, inflammatory diseases as well as rheumatoid arthritis...
November 25, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27880836/towards-the-automatic-classification-of-avian-flight-calls-for-bioacoustic-monitoring
#5
Justin Salamon, Juan Pablo Bello, Andrew Farnsworth, Matt Robbins, Sara Keen, Holger Klinck, Steve Kelling
Automatic classification of animal vocalizations has great potential to enhance the monitoring of species movements and behaviors. This is particularly true for monitoring nocturnal bird migration, where automated classification of migrants' flight calls could yield new biological insights and conservation applications for birds that vocalize during migration. In this paper we investigate the automatic classification of bird species from flight calls, and in particular the relationship between two different problem formulations commonly found in the literature: classifying a short clip containing one of a fixed set of known species (N-class problem) and the continuous monitoring problem, the latter of which is relevant to migration monitoring...
2016: PloS One
https://www.readbyqxmd.com/read/27879519/use-of-the-wattbike-cycle-ergometer-for-attenuation-of-bilateral-pedaling-asymmetry-in-trained-cyclists
#6
David T Kell, Beau Kjerulf Greer
Experienced cyclists typically pedal with a 5-20% bilateral asymmetry in regards to power output. The aim of this study was to determine if visual feedback via the Wattbike cycle ergometer is an effective tool in reducing bilateral pedaling asymmetry in trained cyclists. Twelve subjects completed three 10-minute cycling trials on the Wattbike at a power output consistent with 60% VO2 peak. The three trials consisted of a baseline (BASE) trial in which cyclists pedaled without instruction, a conscious control (CC) trial during which cyclists attempted to pedal symmetrically, and another trial in which cyclists attempted to pedal symmetrically while utilizing visual feedback (VF) of their bilateral power outputs (%) via the Wattbike...
May 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27877155/weak-and-saturable-protein-surfactant-interactions-in-the-denaturation-of-apo-%C3%AE-lactalbumin-by-acidic-and-lactonic-sophorolipid
#7
Kell K Andersen, Brian S Vad, Sophie Roelants, Inge N A van Bogaert, Daniel E Otzen
Biosurfactants are of growing interest as sustainable alternatives to fossil-fuel-derived chemical surfactants, particularly for the detergent industry. To realize this potential, it is necessary to understand how they affect proteins which they may encounter in their applications. However, knowledge of such interactions is limited. Here, we present a study of the interactions between the model protein apo-α-lactalbumin (apo-aLA) and the biosurfactant sophorolipid (SL) produced by the yeast Starmerella bombicola...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27863769/erratum-to-frequencies-of-polymorphisms-of-rh-kell-kidd-duffy-and-diego-systems-of-santa-catarina-southern-brazil-rev-bras-hematol-hemoter-2016-38-3-199-205
#8
Daiane Cobianchi Costa, Alessandra Arruda Schinaider, Thais Mattos Santos, Everaldo José Schörner, Daniel Simon, Sharbel Weidner Maluf, Ana Carolina Rabello de Moraes, Maria Claudia Silva Silva
No abstract text is available yet for this article.
October 2016: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/27834249/population-well-being-measures-help-explain-geographic-disparities-in-life-expectancy-at-the-county-level
#9
Anita Arora, Erica Spatz, Jeph Herrin, Carley Riley, Brita Roy, Kenneth Kell, Carter Coberley, Elizabeth Rula, Harlan M Krumholz
Geographic disparities in life expectancy are substantial and not fully explained by differences in race and socioeconomic status. To develop policies that address these inequalities, it is essential to identify other factors that account for this variation. In this study we investigated whether population well-being-a comprehensive measure of physical, mental, and social health-helps explain geographic variation in life expectancy. At the county level, we found that for every 1-standard-deviation (4.2-point) increase in the well-being score, life expectancy was 1...
November 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27819751/artificial-urinary-sphincter-for-urinary-incontinence-after-radical-prostatectomy-a-historical-cohort-from-2004-to-2015
#10
Augusto Cesar Soares Dos Santos, Luíza de Oliveira Rodrigues, Daniela Castelo Azevedo, Lélia Maria de Almeida Carvalho, Mariana Ribeiro Fernandes, Sandra de Oliveira Sapori Avelar, Maria Glória Cruvinel Horta, Silvana Márcia Bruschi Kelles
This study aimed to retrospectively evaluate a cohort of patients with prostate cancer and persistent urinary incontinence after radical prostatectomy. From January 2004 to December 2015, eighty-six individuals were identified to have received an AUS im¬plant, provided by a private nonprofit HMO operating in Belo Horizonte, Brazil. On total, there were 91 AUS implants, with a median interval between radical prostatectomy and AUS implant of 3.6 years (IQR 1.9 to 5.5). The rate of AUS cumulative survival, after a median follow-up of 4...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27799623/interferon-lambda-4-expression-is-suppressed-by-the-host-during-viral-infection
#11
MeeAe Hong, Johannes Schwerk, Chrissie Lim, Alison Kell, Abigail Jarret, Joseph Pangallo, Yueh-Ming Loo, Shuanghu Liu, Curt H Hagedorn, Michael Gale, Ram Savan
Interferon (IFN) lambdas are critical antiviral effectors in hepatic and mucosal infections. Although IFNλ1, IFNλ2, and IFNλ3 act antiviral, genetic association studies have shown that expression of the recently discovered IFNL4 is detrimental to hepatitis C virus (HCV) infection through a yet unknown mechanism. Intriguingly, human IFNL4 harbors a genetic variant that introduces a premature stop codon. We performed a molecular and biochemical characterization of IFNλ4 to determine its role and regulation of expression...
November 14, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27798603/zika-virus-infection-damages-the-testes-in-mice
#12
Jennifer Govero, Prabagaran Esakky, Suzanne M Scheaffer, Estefania Fernandez, Andrea Drury, Derek J Platt, Matthew J Gorman, Justin M Richner, Elizabeth A Caine, Vanessa Salazar, Kelle H Moley, Michael S Diamond
Zika virus (ZIKV) infection of pregnant women can cause congenital malformations including microcephaly, which has focused global attention on this emerging pathogen(1). In addition to transmission by mosquitoes, ZIKV can be detected in the seminal fluid of affected males for extended periods of time and transmitted sexually(2). Here, using a mouse-adapted African ZIKV strain (Dakar 41519), we evaluated the consequences of infection in the male reproductive tract of mice. We observed persistence of ZIKV, but not the closely related Dengue virus (DENV), in the testis and epididymis of male mice, and this was associated with tissue injury that caused diminished testosterone and inhibin B levels, and oligospermia...
October 31, 2016: Nature
https://www.readbyqxmd.com/read/27794527/the-challenges-of-daratumumab-in-transfusion-medicine
#13
REVIEW
Michael F Dizon
The field of transfusion medicine has evolved rapidly in recent years, but the central principle of transfusion is still simple, namely, the antigen-antibody interaction. Daratumumab (DARA), a monoclonal antibody (MoAb), was developed to treat relapsed/refractory multiple myeloma (RRMM). DARA works by targeting the CD38 portion of malignant cells; however, this drug attaches to the red blood cell (RBC) reagents used in blood banks, further complicating the antibody identification work-up. The AABB (formerly known as the American Association of Blood Banks) has issued a memorandum on how blood banks can effectively address panreactivity caused by DARA...
October 28, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27788064/provision-of-clinical-preventive-services-by-community-pharmacists
#14
Sarah E Kelling, Angela Rondon-Begazo, Natalie A DiPietro Mager, Bethany L Murphy, David R Bright
Community pharmacists are highly accessible health care professionals, providing opportunities for partnerships with other health care and public health professionals to expand the population's access to clinical preventive services. To document examples of the community pharmacist's role in providing clinical preventive services to the general population, we conducted PubMed searches using the key word "community pharmacy" and key words from the US Preventive Services Task Force recommendations rated A or B...
October 27, 2016: Preventing Chronic Disease
https://www.readbyqxmd.com/read/27770530/some-clinically-important-erythrocyte-blood-group-antigens-in-donors
#15
I Tsintsadze, T Gorgoshadze, S Donskov, L Akhvlediani, M Nagervadze
The distribution of erythrocyte blood group antigens was evaluated among 656 donors; samples were provided by the diagnostic laboratory "Medina" Ltd Health Centre of Batumi. Lab analysis of the sample was conducted by the immunogenetics laboratory at Batumi Shota Rustaveli State University. The frequency of the ABO allele system in donors was as follows: r (0.70), q (0.23), p (0.07). The distribution of Rhesus (Rh) factor in the donor population was as follows: Rh(-) was found among 16.3±1.43% of investigated donors; the Rh(+) phenotype was found in 83...
September 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27744465/assessment-of-demographic-and-clinical-characteristics-on-functional-status-and-disability-of-patients-with-stroke
#16
Derya Memis, Erkan Kozanoglu, Bayram Kelle, Mustafa K Goncu
OBJECTIVE: To determine the effects of demographic and clinical characteristics on mobility, disability, and activities of daily life of patients with stroke. METHODS: This cross-sectional clinical study was performed in the Department of Physical Medicine and Rehabilitation in Cukurova University Faculty of Medicine in Adana, Turkey, between February 2011 and December 2011. The study included 126 patients with stroke. The Brunnstrom recovery scale (BRS), functional ambulation classification scale (FACS), modified Barthel index (MBI), modified Rankin scale (MRS), and Rivermead mobility index (RMI) were used in the evaluation of the functional status of stroke patients...
October 2016: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/27738810/left-ventricular-ejection-fraction-and-presence-of-myocardial-necrosis-assessed-by-cardiac-magnetic-resonance-imaging-correctly-risk-stratify-patients-with-stable-coronary-artery-disease-a-multi-center-all-comers-trial
#17
Dominik Buckert, Sebastian Kelle, Sebastian Buss, Grigorios Korosoglou, Rolf Gebker, Ralf Birkemeyer, Wolfgang Rottbauer, Hugo Katus, Burkert Pieske, Peter Bernhardt
BACKGROUND: Cardiac magnetic resonance imaging (CMR) has become a diagnostic modality that allows for prognostic risk stratification in various cardiac diseases. CMR derived detection of myocardial necrosis by late gadolinium enhancement (LGE) and assessment of left ventricular functional parameters such as left-ventricular ejection fraction (LVEF) have been proven to be significantly associated with outcome and prognosis. Our study focusses on the validation of specific thresholds for these parameters in a multi-center daily all-comers cohort of stable coronary artery disease (CAD) patients...
October 13, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27736133/the-order-of-disorder-deconstructing-visual-disorder-and-its-effect-on-rule-breaking
#18
Hiroki P Kotabe, Omid Kardan, Marc G Berman
Disorderly environments are linked to disorderly behaviors. Broken windows theory (Wilson & Kelling, 1982), an influential theory of crime and rule-breaking, assumes that scene-level social disorder cues (e.g., litter, graffiti) cause people to reason that they can get away with breaking rules. But what if part of the story is not about such complex social reasoning? Recent research suggests that basic visual disorder cues may be sufficient to encourage complex rule-breaking behavior. To test this hypothesis, we first conducted a set of experiments (Experiments 1-3) in which we identified basic visual disorder cues that generalize across visual stimuli with a variety of semantic content...
October 13, 2016: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/27731448/recent-advances-in-x-ray-compatible-microfluidics-for-applications-in-soft-materials-and-life-sciences
#19
Aghiad Ghazal, Josiane P Lafleur, Kell Mortensen, Jörg P Kutter, Lise Arleth, Grethe V Jensen
The increasingly narrow and brilliant beams at X-ray facilities reduce the requirements for both sample volume and data acquisition time. This creates new possibilities for the types and number of sample conditions that can be examined but simultaneously increases the demands in terms of sample preparation. Microfluidic-based sample preparation techniques have emerged as elegant alternatives that can be integrated directly into the experimental X-ray setup remedying several shortcomings of more traditional methods...
October 12, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27730708/an-innovative-test-for-non-invasive-kell-genotyping-on-circulating-fetal-dna-by-means-of-the-allelic-discrimination-of-k1-and-k2-antigens
#20
Fabiana Cro', Cristina Lapucci, Emilio Vicari, Ginevra Salsi, Nicola Rizzo, Antonio Farina
OBJECTIVE: The aim of this study was to present a new method for fetal Kell genotyping by means of the allelic discrimination of K1 and K2 in real-time polymerase chain reaction (PCR). METHODS: Real-time quantitative polymerase chain reaction incorporating an allele-specific primer was developed for detecting the K allele of KEL. RESULTS: By means of this method, the K1/K2 genotype was able to be determined in all blood samples analyzed. Results using cell-free fetal DNA (cffDNA) from two Kell-negative pregnant women confirmed the Kell-positive genotype of fetuses...
December 2016: American Journal of Reproductive Immunology: AJRI
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