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https://www.readbyqxmd.com/read/29330014/frequency-of-red-blood-cell-genotypes-in-multi-transfused-patients-and-blood-donors-from-minas-gerais-southeast-brazil
#1
Vitor Mendonça Alves, Fernanda Bernadelli De Vito, Paulo Roberto Juliano Martins, Sheila Soares Silva, Lilian Castilho, Helio Moraes-Souza
BACKGROUND AND OBJECTIVES: The frequency of red blood cell (RBC) antigens in Brazil varies due to differences in the ethnic groups in different regions; however, these studies have not been performed in Minas Gerais, where African admixture is more prevalent in comparison with other states. Due to these facts, this study aimed to determine the frequency of RBC genotypes on Rh, Kell, Duffy and Kidd systems in blood donors and multi-transfused patients from Minas Gerais, Southeast Brazil...
December 16, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29316402/sorting-of-semiconducting-single-walled-carbon-nanotube-in-polar-solvents-with-an-amphiphilic-conjugated-polymer-provides-general-guidelines-for-enrichment
#2
Jianying Ouyang, Jianfu Ding, Jacques Lefebvre, Zhao Li, Chang Guo, Arnold J Kell, Patrick R L Malenfant
Conjugated polymer extraction (CPE) has been shown to be a highly effective method to isolate high purity semiconducting single-walled carbon nanotubes (sc-SWCNTs). In both literature reports and industrial manufacturing, this method has enabled enrichment of sc-SWCNTs with high purity (≥ 99.9%). High selectivity is typically obtained in non-polar aromatic solvents, yet polar solvents may provide process improvements in terms of yield, purity and efficiency. Using a novel amphiphilic fluorene-alt-pyridine conjugated copolymer with hydrophilic side chains we have investigated the enrichment of sc-SWCNTs in polar solvents...
January 9, 2018: ACS Nano
https://www.readbyqxmd.com/read/29313505/effectiveness-safety-and-cost-of-partial-exchange-transfusions-in-patients-with-sickle-cell-anemia-at-a-sickle-cell-disease-center-in-sub-saharan-africa
#3
P Boma Muteb, J F J Kaluila Mamba, P Muhau Pfutila, V Bilo, J D Panda Mulefu, D A Diallo
The partial exchange transfusions necessary for management of some sickle-cell complications raise the issue of effectiveness in the context of limited resources and inadequate blood safety. This study evaluated the effectiveness, safety, and cost of partial exchange transfusions in 39 patients with sickle-cell anemia in Lubumbashi, looking at the patients' age and gender and the tolerability and direct cost of the transfusions. Excel and SPSS 18 were used for data entry and analysis. Chi2 and Fisher exact tests were used for comparisons...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29284116/the-potential-therapeutic-effects-of-ergothioneine-in-pre-eclampsia
#4
REVIEW
Robert N Kerley, Cathal McCarthy, Douglas B Kell, Louise C Kenny
Ergothioneine (ERG), is a water-soluble amino acid that is derived entirely from dietary sources. It has received much attention as a therapeutic agent due to its anti-oxidant properties, and there are claims of preferential accumulation within high oxidative stress organs. Pre-eclampsia, a condition accompanied by increased oxidative stress, is one of the leading causes of maternal morbidity and mortality. Despite intense research efforts, its aetiologies remain somewhat unclear and there are still no effective treatment options...
December 25, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29280152/silent-kel-alleles-identified-from-japanese-individuals-with-the-ko-phenotype
#5
T Onodera, M Kawai, K Obara, T Enomoto, K Sasaki, T Osabe, K Ogasawara, C Toyoda, H Tsuneyama, M Uchikawa, S Inaba, M Satake
BACKGROUND AND OBJECTIVE: The rare Ko phenotype lacks all 36 antigens in the Kell blood system. The molecular basis of the Ko phenotype has been investigated, and more than 40 silent KEL alleles are reported by many investigators. The majority of silent alleles are the KEL*02 background. Here, we report molecular genetic analysis of the KEL gene in Japanese individuals with the Ko phenotype. MATERIALS AND METHODS: The Ko phenotype was screened from Japanese blood donors for several years using monoclonal anti-Ku or anti-K14 by an automated blood grouping system PK7300...
December 27, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29262357/myoglobin-and-%C3%AE-lactalbumin-form-smaller-complexes-with-the-biosurfactant-rhamnolipid-than-with-sds
#6
Henriette Gavlshøj Mortensen, Jens Kvist Madsen, Kell K Andersen, Thomas Vosegaard, G Roshan Deen, Daniel E Otzen, Jan Skov Pedersen
Biosurfactants (BSs) attract increasing attention as sustainable alternatives to petroleum-derived surfactants. This necessitates structural insight into how BSs interact with proteins encountered by current chemical surfactants. Thus, small-angle x-ray scattering (SAXS) has been used for studying the structures of complexes made of the proteins α-Lactalbumin (αLA) and myoglobin (Mb) with the biosurfactant rhamnolipid (RL). For comparison, complexes between αLA and the chemical surfactant sodium dodecyl sulfate (SDS) were also investigated...
December 19, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29250791/successful-management-of-severe-red-blood-cell-alloimmunization-in-pregnancy-with-a-combination-of-therapeutic-plasma-exchange-intravenous-immune-globulin-and-intrauterine-transfusion
#7
Laura C Nwogu, Kenneth J Moise, Kimberly L Klein, Hlaing Tint, Brian Castillo, Yu Bai
BACKGROUND: Antibodies to Rhesus and Kell antigens have been associated with severe hemolytic disease of the fetus and newborn (HDFN) necessitating intrauterine transfusion (IUT) of red blood cells (RBCs). We report a case series of five women with severe HDFN secondary to maternal RBC alloimmunization who were successfully managed with therapeutic plasma exchange (TPE), intravenous immune globulin (IVIG), and IUT. STUDY DESIGN AND METHODS: This is a retrospective case series of five women with severe HDFN who underwent a total of three TPE procedures during Weeks 10 to 13 of pregnancy, followed by weekly IVIG infusions...
December 17, 2017: Transfusion
https://www.readbyqxmd.com/read/29249950/non-linear-relationship-between-bold-activation-and-amplitude-of-beta-oscillations-in-the-supplementary-motor-area-during-rhythmic-finger-tapping-and-internal-timing
#8
Florian Gompf, Anja Pflug, Helmut Laufs, Christian A Kell
Functional imaging studies using BOLD contrasts have consistently reported activation of the supplementary motor area (SMA) both during motor and internal timing tasks. Opposing findings, however, have been shown for the modulation of beta oscillations in the SMA. While movement suppresses beta oscillations in the SMA, motor and non-motor tasks that rely on internal timing increase the amplitude of beta oscillations in the SMA. These independent observations suggest that the relationship between beta oscillations and BOLD activation is more complex than previously thought...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29242355/the-bioactive-protein-ligand-conformation-of-glun2c-selective-positive-allosteric-modulators-bound-to-the-nmda-receptor
#9
Thomas Maxwell Kaiser, Steven A Kell, Hirofumi Kusumoto, Gil Shaulsky, Subhrajit Bhattacharya, Matthew P Epplin, Katie L Strong, Eric J Miller, Bryan D Cox, David S Menaldino, Dennis C Liotta, Stephen F Traynelis, Pieter Buys Burger
NMDA receptors are ligand-gated, cation-selective channels that mediate a slow component of excitatory synaptic transmission. Subunit-selective positive allosteric modulators of NMDA receptor function have therapeutically-relevant effects on multiple processes in the brain. A series of pyrrolidinones, such as PYD-106, that selectively potentiate NMDA receptors that contain the GluN2C subunit have structural determinants of activity that reside between the GluN2C amino terminal domain and the GluN2C agonist binding domain, suggesting a unique site of action...
December 14, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/29211127/evaluation-of-stress-distribution-in-endodontically-weakened-teeth-restored-with-different-crown-materials-3d-fea-analysis
#10
Izabela C M Moris, Carolina Alves Moscardini, Luana Kelle Batista Moura, Yara Teresinha Corrêa Silva-Sousa, Erica Alves Gomes
This study evaluated the stress distribution in endodontically treated teeth, weakened (W) or not weakened (NW), restored with different materials of prosthetic crown using 3D-FEA. Models of a maxillary canine were constructed based on micro-CT images and divided into the groups: G1 (control) - sound tooth; G2 to G7 - endodontically treated teeth restored with glass fiber post (GFP); which G2 to G4 simulated NW root and G5 to G7 simulated W root. For crown material the teeth were restored with: G2 and G5: metallic coping and ceramic veneering, G3 and G6: zirconia coping and ceramic veneering, G4 and G7: alumina coping and ceramic veneering...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29209511/effectiveness-of-composting-as-a-biosecure-disposal-method-for-porcine-epidemic-diarrhea-virus-pedv-infected-pig-carcasses
#11
Sarah Vitosh-Sillman, John Dustin Loy, Bruce Brodersen, Clayton Kelling, Kent Eskridge, Amy Millmier Schmidt
Background: Porcine epidemic diarrhea virus (PEDV) is an enteric disease of swine that has emerged as a worldwide threat to swine herd health and production. Substantial research has been conducted to assess viability of the virus on surfaces of vehicles and equipment, in feed and water, and on production building surfaces, but little is known about the persistence in PEDV-infected carcasses and effective disposal methods thereof. This study was conducted to quantify the persistence of PEDV RNA via quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) at various time-temperature combinations and in infected piglet carcasses subjected to composting...
2017: Porcine Health Management
https://www.readbyqxmd.com/read/29198987/energy-landscape-of-the-intact-and-destabilized-fmo-antennas-from-c-tepidum-and-the-l122q-mutant-low-temperature-spectroscopy-and-modeling-study
#12
Anton Khmelnitskiy, Adam Kell, Tonu Reinot, Rafael G Saer, Robert E Blankenship, Ryszard Jankowiak
We discuss the excitonic energy landscape of the typically studied wild-type (WT) Fenna-Matthews-Olson (FMO) antenna protein from the green sulfur bacterium Chlorobaculum tepidum (referred to as WTM), which is described as a mixture of intact (WTI) and destabilized (WTD) complexes. Optical spectra of WTM and the L122Q mutant (where leucine 122 near BChl 8 is replaced with glutamine) are compared to WTI FMO. We show that WTM and L122Q samples are mixtures of two subpopulations of proteins, most likely induced by protein conformational changes during the isolation/purification procedures...
November 30, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29197052/correction-to-adaptation-in-toxic-environments-comparative-genomics-of-loci-carrying-antibiotic-resistance-genes-derived-from-acid-mine-drainage-waters
#13
Florence Arsène-Ploetze, Olfa Chiboub, Didier Lièvremont, Julien Farasin, Kelle C Freel, Stephanie Fouteau, Valérie Barbe
The original version of this article unfortunately contains a mistake.
December 1, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29193130/evaluation-of-a-lateral-flow-based-technology-card-for-blood-typing-using-a-simplified-protocol-in-a-model-of-extreme-blood-sampling-conditions
#14
Benoît Clavier, Thomas Pouget, Anne Sailliol
BACKGROUND: Life-threatening situations requiring blood transfusion under extreme conditions or in remote and austere locations, such as the battlefield or in traffic accidents, would benefit from reliable blood typing practices that are easily understood by a nonscientist or nonlaboratory technician and provide quick results. STUDY DESIGN AND METHODS: A simplified protocol was developed for the lateral flow-based device MDmulticard ABO-D-Rh subgroups-K. Its performance was compared to a reference method (PK7300, Beckman Coulter) in native blood samples from donors...
November 29, 2017: Transfusion
https://www.readbyqxmd.com/read/29175223/implementation-of-a-mindfulness-moment-initiative-for-healthcare-professionals-perceptions-of-facilitators
#15
Karen Duggan, Kell Julliard
CONTEXT: Mindfulness practices in the workplace have experienced rapid growth, with initial evidence suggesting positive outcomes. Even so, little is known about implementing mindfulness-based interventions (MBI), especially internally driven programs led by volunteers rather than experts. OBJECTIVE: This study qualitatively explores volunteer facilitators' perceptions of a short-dose MBI (the mindfulness moment initiative) before and 6 weeks after implementation...
November 23, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/29168302/analysing-and-navigating-natural-products-space-for-generating-small-diverse-but-representative-chemical-libraries
#16
REVIEW
Steve O'Hagan, Douglas B Kell
BACKGROUND: Armed with the digital availability of two natural products libraries, amounting to some 195,885 molecular entities, we ask the question of how we can best sample from them to maximise their 'representativeness' in smaller and more usable libraries of 96, 384, 1152 and 1920 molecules. Purpose and scope. The term 'representativeness' is intended to include diversity, but for numerical reasons (and the likelihood of being able to perform a QSAR) it is necessary to focus on areas of chemical space that are more highly populated...
November 23, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29167779/bibliometric-analysis-on-the-risks-of-oral-cancer-for-people-living-with-hiv-aids
#17
Luana Kelle Batista Moura, Mitra Mobin, Francisca Tereza Coelho Matos, Thiago Lima Monte, Eliana Campelo Lago, Carlos Alberto Monteiro Falcão, Maria Ângela de Arêa Leão Ferraz, Tanit Clementino Santos, Fabrício Ibiapina Tapety, Carla Maria de Carvalho Leite Leal Nunes, Laelson Rochelle Milanês Sousa
No abstract text is available yet for this article.
November 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29166575/chemical-characterization-and-pharmacological-assessment-of-cashew-gum-extract-anacardium-occidentale-l-polysaccharide-free
#18
Daiany Priscilla Bueno da Silva, Iziara Ferreira Florentino, Lorrane Kelle da Silva Moreira, Adriane Ferreira Brito, Verônica Vale Carvalho, Géssica Adriana Vasconcelos, Boniek Gontijo Vaz, Marcus Antônio Pereira-Junior, Kátia Flávia Fernandes, Elson Alves Costa
ETHNOPHARMACOLOGICAL RELEVANCE: The cashew gum (Anacardium occidentale L.) is used in Brazilian traditional medicine in the treatment of inflammatory conditions, asthma, diabetes, and gastrointestinal disturbs. AIM OF THE STUDY: The present study was aimed the chemical characterization and the investigation of the antinociceptive and anti-inflammatory activities of cashew gum aqueous extract without the presence of polysaccharides in its composition (CGE). MATERIALS AND METHODS: The CGE was obtained after precipitation and removal of polysaccharides using acetone...
November 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29143708/genome-wide-association-study-for-growth-traits-in-nelore-cattle
#19
A P N Terakado, R B Costa, G M F de Camargo, N Irano, T Bresolin, L Takada, C V D Carvalho, H N Oliveira, R Carvalheiro, F Baldi, L G de Albuquerque
The objective of this study was to investigate the association of single nucleotide polymorphisms (SNPs) with birth weight, weight gain from birth to weaning and from weaning to yearling, yearling height and cow weight in Nelore cattle. Data from 5064 animals participating in the DeltaGen and PAINT breeding programs were used. The animals were genotyped with a panel of 777 962 SNPs (Illumina BovineHD BeadChip) and 412 993 SNPs remained after quality control analysis of the genomic data. A genome-wide association study was performed using a single-step methodology...
November 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29142193/pten-is-a-protein-phosphatase-that-targets-active-ptk6-and-inhibits-ptk6-oncogenic-signaling-in-prostate-cancer
#20
Darren J Wozniak, Andre Kajdacsy-Balla, Virgilia Macias, Susan Ball-Kell, Morgan L Zenner, Wenjun Bie, Angela L Tyner
PTEN activity is often lost in prostate cancer. We show that the tyrosine kinase PTK6 (BRK) is a PTEN substrate. Phosphorylation of PTK6 tyrosine 342 (PY342) promotes activation, while phosphorylation of tyrosine 447 (PY447) regulates auto-inhibition. Introduction of PTEN into a PTEN null prostate cancer cell line leads to dephosphorylation of PY342 but not PY447 and PTK6 inhibition. Conversely, PTEN knockdown promotes PTK6 activation in PTEN positive cells. Using a variety of PTEN mutant constructs, we show that protein phosphatase activity of PTEN targets PTK6, with efficiency similar to PTP1B, a phosphatase that directly dephosphorylates PTK6 Y342...
November 15, 2017: Nature Communications
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