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https://www.readbyqxmd.com/read/28166712/experimental-acute-infection-of-alpacas-with-bovine-viral-diarrhea-virus-1-subgenotype-b-alters-peripheral-blood-and-galt-leukocyte-subsets
#1
Christina L Topliff, Abdulrahman A Alkheraif, Charles A Kuszynski, William C Davis, David J Steffen, Jack A Schmitz, Kent M Eskridge, Bryan Charleston, Jamie N Henningson, Clayton L Kelling
Bovine viral diarrhea virus (BVDV) is a pathogen in cattle and alpacas ( Vicugna pacos), causing acute and persistent BVDV infections. We characterized the effect of acute BVDV infection on the immune system of alpacas by determining lymphocyte subpopulations in peripheral blood and gut-associated lymphoid tissues (GALT) as well as serum interferon levels. Alpacas were experimentally infected with BVDV-1b (strain CO-06). Peripheral blood leukocytes were isolated at 0, 3, 6, and 9 d postinfection (dpi), and leukocytes of GALT at 9 dpi, and evaluated using flow cytometry...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28159727/a-p-coumaroyl-esterase-from-rhizoctonia-solani-with-a-pronounced-chlorogenic-acid-esterase-activity
#2
Annabel Nieter, Sebastian Kelle, Diana Linke, Ralf G Berger
Extracellular esterase activity was detected in submerged cultures of Rhizoctonia solani grown in the presence of sugar beet pectin or Tween 80. Putative type B feruloyl esterase (FAE) coding sequences found in the genome data of the basidiomycete were heterologously expressed in Pichia pastoris. Recombinant enzyme production on the 5-L bioreactor scale (RspCAE: 3245UL(-1)) exceeded the productivity of the wild type strain by a factor of 800. Based on substrate specificity profiling, the purified recombinant RspCAE was classified as a p-coumaroyl esterase (pCAE) with a pronounced chlorogenic acid esterase side activity...
January 31, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28143743/influence-of-diurnal-photosynthetic-activity-on-the-morphology-structure-and-thermal-properties-of-normal-and-waxy-barley-starch
#3
Avi Goldstein, George Annor, Varatharajan Vamadevan, Ian Tetlow, Jacob J K Kirkensgaard, Kell Mortensen, Andreas Blennow, Kim H Hebelstrup, Eric Bertoft
This study investigated the influence of diurnal photosynthetic activity on the morphology, molecular composition, crystallinity, and gelatinization properties of normal barley starch (NBS) and waxy barley starch (WBS) granules from plants cultivated in a greenhouse under normal diurnal (16h light) or constant light photosynthetic conditions. Growth rings were observed in all starch samples regardless of lighting conditions. The size distribution of whole and debranched WBS analyzed by gel-permeation chromatography did not appear to be influenced by the different lighting regimes, however, a greater relative crystallinity measured by wide-angle X-ray scattering and greater crystalline quality as judged by differential scanning calorimetry was observed under the diurnal lighting regime...
January 29, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28131167/conversion-to-carbidopa-and-levodopa-extended-release-ipx066-followed-by-its-extended-use-in-patients-previously-taking-controlled-release-carbidopa-levodopa-for-advanced-parkinson-s-disease
#4
James Tetrud, Paul Nausieda, David Kreitzman, Grace S Liang, Anette Nieves, Andrew P Duker, Robert A Hauser, Eric S Farbman, Aaron Ellenbogen, Ann Hsu, Sherron Kell, Sarita Khanna, Robert Rubens, Suneel Gupta
BACKGROUND: IPX066 (Rytary®; carbidopa and levodopa [CD-LD] extended-release capsules) was designed to achieve therapeutic LD plasma concentrations within 1h of dosing and maintain LD concentrations for a prolonged duration in early or advanced Parkinson's disease (PD). METHODS: In this open-label study, patients underwent 6weeks of conversion to IPX066 from their prior controlled-release (CR)±immediate-release (IR) CD-LD therapy and 6months of maintenance (with an additional 6months of IPX066 at some sites)...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28130368/commentary-on-goodacre-r-timmins-%C3%A3-m-rooney-pj-rowland-jj-kell-db-rapid-identification-of-streptococcus-and-enterococcus-species-using-diffuse-reflectance-absorbance-fourier-transform-infrared-spectroscopy-and-artificial-neural-networks-fems-microbiol-lett
#5
Royston Goodacre, Douglas B Kell
This is an invited review/commentary by the first and last authors of a paper that was the most cited in FEMS Microbiology Letters for 1996, presently showing in excess of 150 citations at Web of Science, and over 200 at Google Scholar. It was the first paper in which diffuse-reflectance-absorbance FT-IR spectroscopy was used with a supervised learning method in the form of artificial neural networks, and showed that this combination could succeed in discriminating a series of closely related, clinically relevant, Gram-positive bacterial strains...
January 26, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28124538/artificial-urinary-sphincter-for-urinary-incontinence-after-radical-prostatectomy-a-historical-cohort-from-2004-to-2015
#6
Augusto Cesar Soares Dos Santos, Luíza de Oliveira Rodrigues, Daniela Castelo Azevedo, Lélia Maria de Almeida Carvalho, Mariana Ribeiro Fernandes, Sandra de Oliveira Sapori Avelar, Maria Glória Cruvinel Horta, Silvana Márcia Bruschi Kelles
This study aimed to retrospectively evaluate a cohort of patients with prostate cancer and persistent urinary incontinence after radical prostatectomy. From January 2004 to December 2015, eighty-six individuals were identified to have received an AUS implant, provided by a private nonprofit HMO operating in Belo Horizonte, Brazil. On total, there were 91 AUS implants, with a median interval between radical prostatectomy and AUS implant of 3.6 years (IQR 1.9 to 5.5). The rate of AUS cumulative survival, after a median follow-up of 4...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28097704/prophylactic-rhce-and-kell-antigen-matching-impact-on-alloimmunization-in-transfusion-dependent-patients-with-myelodysplastic-syndromes
#7
Y Lin, A Saskin, R A Wells, M Lenis, A Mamedov, J Callum, R Buckstein
BACKGROUND AND OBJECTIVES: Thirty to 80 per cent of patients with myelodysplastic syndromes (MDS) become transfusion-dependent and are at risk for red blood cell (RBC) alloimmunization. This study compared alloimmunization rates in transfusion-dependent patients with MDS at an institution with a policy of prophylactic antigen matching for RhCE and K (PAM) with those transfused at institutions without such a policy (non-PAM). MATERIALS AND METHODS: Transfusion records were retrospectively reviewed to determine total number of RBC transfusions received, whether RBC phenotyping was performed, the type and date of first alloantibody development and receipt of prophylactic antigen matching for RhCE and K...
January 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28040400/emerging-strategies-of-blood-group-genotyping-for-patients-with-hemoglobinopathies
#8
REVIEW
A Belsito, K Magnussen, C Napoli
Red cell alloimmunization is a serious problem in chronically transfused patients. A number of high-throughput DNA assays have been developed to extend or replace traditional serologic antigen typing. DNA-based typing methods may be easily automated and multiplexed, and provide reliable information on a patient. Molecular genotyping promises to become cheaper, being not dependent on serologic immunoglobulin reagents. Patients with hemoglobinopathies could benefit from receiving extended genomic typing. This could limit post transfusional complications depending on subtle antigenic differences between donors and patients...
December 9, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28038786/epidemiologic-data-of-trauma-related-lower-limb-amputees-a-single-center-10-year-experience
#9
Evren Yaşar, Fatih Tok, Serdar Kesikburun, A Mustafa Ada, Bayram Kelle, A Salim Göktepe, Kamil Yazıcıoğlu, A Kenan Tan
OBJECTIVE: The aim of this study is three fold: 1) to introduce epidemiologic data of patients with trauma-related amputations as a 10-year experience of a rehabitation center; 2) to determine comorbidities and secondary conditions of lower limb loss; 3) to determine the rehospitalization reasons for lower limb amputee patients. MATERIALS AND METHODS: This retrospective study was conducted in a tertiary rehabilitation center in Turkey. Clinical and demographic data of amputees including sex, age, employment status, time since amputation, time after amputation to first hospitalization, length of hospitalization, how many times the patient was hospitalized, reason for hospitalization, stump complications, comorbid conditions, amputation level and K classifacation were documented...
February 2017: Injury
https://www.readbyqxmd.com/read/28028036/reduced-islet-function-contributes-to-impaired-glucose-homeostasis-in-fructose-fed-mice
#10
Zeenat A Asghar, Andrew Cusumano, Zihan Yan, Maria S Remedi, Kelle H Moley
Increased sugar consumption, particularly fructose, in the form of sweetened beverages and sweeteners in our diet adversely affects metabolic health. Because these effects are associated with features of the metabolic syndrome in humans, the direct effect of fructose on pancreatic islet function is unknown. Therefore, we examined the islet phenotype of mice fed excess fructose. Fructose-fed mice exhibited fasting hyperglycemia and glucose intolerance but not hyperinsulinemia, dyslipidemia, or hyperuricemia...
February 1, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28012565/healthcare-utilization-for-arthritis-by-indigenous-populations-of-australia-canada-new-zealand-and-the-united-states-a-systematic-review-%C3%A2
#11
REVIEW
Adalberto Loyola-Sanchez, Kelle Hurd, Cheryl Barnabe
PURPOSE: Indigenous populations of Australia, Canada, New Zealand, and the United States of America (USA) experience a higher prevalence of arthritis conditions. Differences in clinical outcomes and mortality may reflect healthcare service use inequities. The objective of this study was to summarize healthcare service use patterns described in the existing literature in order to identify gaps and inform strategies to limit the pronounced negative impact of arthritis on Indigenous populations...
November 1, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28011593/an-informatics-based-approach-to-reducing-heart-failure-all-cause-readmissions-the-stanford-heart-failure-dashboard
#12
Dipanjan Banerjee, Christine Thompson, Charlene Kell, Rajesh Shetty, Yohan Vetteth, Helene Grossman, Aria DiBiase, Michael Fowler
BACKGROUND: Reduction of 30-day all-cause readmissions for heart failure (HF) has become an important quality-of-care metric for health care systems. Many hospitals have implemented quality improvement programs designed to reduce 30-day all-cause readmissions for HF. Electronic medical record (EMR)-based measures have been employed to aid in these efforts, but their use has been largely adjunctive to, rather than integrated with, the overall effort. OBJECTIVES: We hypothesized that a comprehensive EMR-based approach utilizing an HF dashboard in addition to an established HF readmission reduction program would further reduce 30-day all-cause index hospital readmission rates for HF...
December 23, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27988789/systematic-review-of-rheumatic-disease-phenotypes-and-outcomes-in-the-indigenous-populations-of-canada-the-usa-australia-and-new-zealand
#13
REVIEW
Kelle Hurd, Cheryl Barnabe
We performed a systematic review designed to characterize clinical phenotypes and outcomes in Indigenous populations with rheumatic disease to enhance the understanding of how rheumatic disease presents in Indigenous populations and allow for better projection of the healthcare needs of the communities affected. A systematic search was performed in medical (Medline, EMBASE, CINAHL), Indigenous and conference abstract databases (to June 2015). Search terms for Indigenous populations were combined with terms for inflammatory arthritis conditions, connective tissue disorders, crystal arthritis and osteoarthritis...
December 17, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27988005/corrigendum-to-plant-crafted-starches-for-bioplastics-production-carbohydr-polym-152-2016-398-408
#14
Domenico Sagnelli, Kim H Hebelstrup, Eric Leroy, Agnès Rolland-Sabaté, Sophie Guilois, Jacob J K Kirkensgaard, Kell Mortensen, Denis Lourdin, Andreas Blennow
No abstract text is available yet for this article.
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27980845/crystal-structures-of-three-bicyclic-carbohydrate-derivatives
#15
Uwe Schilde, Alexandra Kelling, Sumaira Umbreen, Torsten Linker
The title compounds, [(1R,3R,4R,5R,6S)-4,5-bis-(acet-yloxy)-7-oxo-2-oxabi-cyclo[4.2.0]octan-3-yl]methyl acetate, C14H18O8, (I), [(1S,4R,5S,6R)-5-acet-yloxy-7-hy-droxy-imino-2-oxobi-cyclo-[4.2.0]octan-4-yl acetate, C11H15NO6, (II), and [(3aR,5R,6R,7R,7aS)-6,7-bis-(acet-yloxy)-2-oxo-octa-hydro-pyrano[3,2-b]pyrrol-5-yl]methyl acetate, C14H19NO8, (III), are stable bicyclic carbohydrate derivatives. They can easily be synthesized in a few steps from commercially available glycals. As a result of the ring strain from the four-membered rings in (I) and (II), the conformations of the carbohydrates deviate strongly from the ideal chair form...
December 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27973779/concatemers-of-outer-membrane-protein-a-take-detours-in-the-folding-landscape
#16
Kell K Andersen, Brian Vad, Sahar Omer, Daniel E Otzen
Outer membrane protein A (OmpA) is the most abundant protein in the outer membrane of Escherichia coli. The N-terminal domain forms an eight-stranded membrane-embedded β-barrel that is widely used as a model protein for in vitro folding into the membrane and into surfactant micelles. Under conditions that include a low surfactant concentration, OmpA can form stable higher-order structures by intermolecular association. Other β-barrel membrane proteins also associate to form noncovalently linked trimers in vivo...
December 27, 2016: Biochemistry
https://www.readbyqxmd.com/read/27965958/a-dormant-microbial-component-in-the-development-of-preeclampsia
#17
REVIEW
Douglas B Kell, Louise C Kenny
Preeclampsia (PE) is a complex, multisystem disorder that remains a leading cause of morbidity and mortality in pregnancy. Four main classes of dysregulation accompany PE and are widely considered to contribute to its severity. These are abnormal trophoblast invasion of the placenta, anti-angiogenic responses, oxidative stress, and inflammation. What is lacking, however, is an explanation of how these themselves are caused. We here develop the unifying idea, and the considerable evidence for it, that the originating cause of PE (and of the four classes of dysregulation) is, in fact, microbial infection, that most such microbes are dormant and hence resist detection by conventional (replication-dependent) microbiology, and that by occasional resuscitation and growth it is they that are responsible for all the observable sequelae, including the continuing, chronic inflammation...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27940969/david-kells-o-donel-calderwood
#18
Sandra Calderwood, Robin Calderwood
No abstract text is available yet for this article.
December 9, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27931094/human-lysozyme-peptidase-resistance-is-perturbed-by-the-anionic-glycolipid-biosurfactant-rhamnolipid-produced-by-the-opportunistic-pathogen-pseudomonas-aeruginosa
#19
Kell K Andersen, Brian S Vad, Carsten Scavenius, Jan J Enghild, Daniel E Otzen
Infection by the opportunistic pathogen Pseudomonas aeruginosa (PA) is accompanied by the secretion of virulence factors such as the secondary metabolite rhamnolipid (RL) as well as an array of bacterial enzymes, including the peptidase elastase. The human immune system tries to counter this via defensive proteins such as lysozyme (HLZ). HLZ targets the bacterial cell wall but may also have other antimicrobial activities. The enzyme contains four disulfide bonds and shows high thermodynamic stability and resistance to proteolytic attack...
December 20, 2016: Biochemistry
https://www.readbyqxmd.com/read/27927805/transmission-of-metabolic-dysfunction-across-generations
#20
REVIEW
Kathleen Jaeger, Jessica L Saben, Kelle H Moley
Recent human and animal studies investigating the roles of the genome, epigenome, and environmental cues have identified associations between offspring predisposition to life-long obesity/metabolic disease and epigenetic modifications such as DNA methylation. This review explores the mechanisms by which maternal exposures impair the health of not only the next generation but also potentially future generations of offspring.
January 2017: Physiology
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