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https://www.readbyqxmd.com/read/28620752/fatty-metaplasia-quantification-and-impact-on-regional-myocardial-function-as-assessed-by-advanced-cardiac-mr-imaging
#1
Tomas Lapinskas, Bernhard Schnackenburg, Marc Kouwenhoven, Rolf Gebker, Alexander Berger, Remigijus Zaliunas, Burkert Pieske, Sebastian Kelle
OBJECTIVE: This study aimed to investigate the advantages of recently developed cardiac imaging techniques of fat-water separation and feature tracking to characterize better individuals with chronic myocardial infarction (MI). MATERIALS AND METHODS: Twenty patients who had a previous MI underwent CMR imaging. The study protocol included routine cine and late gadolinium enhancement (LGE) technique. In addition, mDixon LGE imaging was performed in every patient. Left ventricular (LV) circumferential (EccLV) and radial (ErrLV) strain were calculated using dedicated software (CMR(42), Circle, Calgary, Canada)...
June 15, 2017: Magma
https://www.readbyqxmd.com/read/28606531/all-natural-bio-plastics-using-starch-betaglucan-composites
#2
Domenico Sagnelli, Jacob J K Kirkensgaard, Concetta Valeria L Giosafatto, Natalia Ogrodowicz, Krzysztof Kruczała, Mette S Mikkelsen, Jean-Eudes Maigret, Denis Lourdin, Kell Mortensen, Andreas Blennow
Grain polysaccharides represent potential valuable raw materials for next-generation advanced and environmentally friendly plastics. Thermoplastic starch (TPS) is processed using conventional plastic technology, such as casting, extrusion, and molding. However, to adapt the starch to specific functionalities chemical modifications or blending with synthetic polymers, such as polycaprolactone are required (e.g. Mater-Bi). As an alternative, all-natural and compostable bio-plastics can be produced by blending starch with other polysaccharides...
September 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28605695/bimanual-tapping-of-a-syncopated-rhythm-reveals-hemispheric-preferences-for-relative-movement-frequencies
#3
Anja Pflug, Florian Gompf, Christian Alexander Kell
In bimanual multifrequency tapping, right-handers commonly use the right hand to tap the relatively higher rate and the left hand to tap the relatively lower rate. This could be due to hemispheric specializations for the processing of relative frequencies. An extension of the double-filtering-by-frequency theory to motor control proposes a left hemispheric specialization for the control of relatively high and a right hemispheric specialization for the control of relatively low tapping rates. We investigated timing variability and rhythmic accentuation in right handers tapping mono- and multifrequent bimanual rhythms to test the predictions of the double-filtering-by-frequency theory...
June 9, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28604623/dynamic-contrast-enhanced-ultrasound-of-colorectal-liver-metastases-as-an-imaging-modality-for-early-response-prediction-to-chemotherapy
#4
Marie Benzon Mogensen, Martin Lundsgaard Hansen, Birthe Merete Henriksen, Thomas Axelsen, Ben Vainer, Kell Osterlind, Michael Bachmann Nielsen
Our aim was to investigate whether dynamic contrast-enhanced ultrasound (DCE-US) can detect early changes in perfusion of colorectal liver metastases after initiation of chemotherapy. Newly diagnosed patients with colorectal cancer with liver metastases were enrolled in this explorative prospective study. Patients were treated with capecitabine or 5-fluorouracil-based chemotherapy with or without bevacizumab. DCE-US was performed before therapy (baseline) and again 10 days after initiation of treatment. Change in contrast-enhancement in one liver metastasis (indicator lesion) was measured...
June 12, 2017: Diagnostics
https://www.readbyqxmd.com/read/28596662/rh-and-kell-phenotype-matched-blood-versus-randomly-selected-and-conventionally-cross-matched-blood-on-incidence-of-alloimmunization
#5
Raj Nath Makroo, Soma Agrawal, Mohit Chowdhry
There is paucity of literature regarding efficacy of transfusion of Rh and Kell matched blood in reducing alloimmunization risk among non-chronically transfused patients. A prospective study to compare efficacy of Rh and Kell phenotype matched blood over randomly selected and conventionally cross-matched blood on the incidence of alloimmunization in patients undergoing cardiac surgery was carried out in the Department of Transfusion Medicine at Indraprastha Apollo Hospitals, New Delhi, from 1st September, 2013 to 31st December, 2014...
June 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28586379/lamp-2-absence-interferes-with-plasma-membrane-repair-and-decreases-t-cruzi-host-cell-invasion
#6
Natália Fernanda Couto, Dina Pedersane, Luisa Rezende, Patrícia P Dias, Tayanne L Corbani, Lívia C Bentini, Anny C S Oliveira, Ludmila F Kelles, Thiago Castro-Gomes, Luciana O Andrade
Trypanosoma cruzi enters host cells by subverting the mechanism of cell membrane repair. In this process, the parasite induces small injuries in the host cell membrane leading to calcium entry and lysosomal exocytosis, which are followed by compensatory endocytosis events that drive parasites into host cells. We have previously shown that absence of both LAMP-1 and 2, major components of lysosomal membranes, decreases invasion of T. cruzi into host cells, but the mechanism by which they interfere with parasite invasion has not been described...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28585832/polymer-chlorosome-nanocomposites-consisting-of-non-native-combinations-of-self-assembling-bacteriochlorophylls
#7
Gregory S Orf, Aaron M Collins, Dariusz M Niedzwiedzki, Marcus Tank, Vera Thiel, Adam Kell, Donald A Bryant, Gabriel A Montaño, Robert E Blankenship
Chlorosomes are one of the characteristic light-harvesting antennas from green sulfur bacteria. These complexes represent a unique paradigm: self-assembly of bacteriochlorophyll pigments within a lipid monolayer without the influence of protein. Because of their large size and reduced complexity, they have been targeted as models for the development of bioinspired light-harvesting arrays. We report the production of biohybrid light-harvesting nanocomposites mimicking chlorosomes, composed of amphiphilic diblock copolymer membrane bodies that incorporate thousands of natural self-assembling bacteriochlorophyll molecules derived from green sulfur bacteria...
June 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28571009/surgery-is-an-effective-option-after-failure-of-chemoradiation-in-cancers-of-the-anal-canal-and-anal-margin
#8
Jean-Baptiste Delhorme, François Severac, Waisse Waissi, Benoit Romain, Delphine Antoni, Kelle C Freel, Catherine Schumacher, Serge Rohr, Cécile Brigand, Georges Noël
BACKGROUND: Surgery for anal canal cancer (ACC) and anal margin cancer (AMC) is the only curative option after failure of chemoradiotherapy (CRT). This study aimed to determine the efficacy of surgery for ACC or AMC after failed CRT. METHODS: This was a single-centre, retrospective study of 161 patients initially treated with CRT. We compared the survival rates of patients successfully treated by CRT with those of patients whose CRT failed (both surgically salvaged and treated palliatively)...
June 2, 2017: Oncology
https://www.readbyqxmd.com/read/28539416/the-extinction-of-cocaine-seeking-requires-a-window-of-infralimbic-pyramidal-neuron-activity-after-unreinforced-lever-presses
#9
Andrea L Gutman, Kelle E Nett, Caitlin V Cosme, Wensday R Worth, Subhash C Gupta, John A Wemmie, Ryan T LaLumiere
The infralimbic cortex (IL) mediates the extinction learning and active suppression of cocaine-seeking behavior. However, the precise temporal relationship among IL activity, lever pressing, and extinction learning is unclear. To address this issue, we employed activity-guided optogenetics in male Sprague-Dawley rats to optically silence IL pyramidal neurons for 20 s immediately following unreinforced lever presses during early extinction training after cocaine self-administration. Optical inhibition of the IL increased active lever pressing during shortened extinction sessions but did not alter the retention of the extinction learning as assessed in ensuing extinction sessions with no optical inhibition...
May 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28531352/conformational-complexity-in-the-lh2-antenna-of-the-purple-sulfur-bacterium-allochromatium-vinosum-revealed-by-hole-burning-spectroscopy
#10
Adam Kell, Mahboobe Jassas, Khem Acharya, Kirsty Hacking, Richard J Cogdell, Ryszard Jankowiak
This work discusses the protein conformational complexity of the B800-850 LH2 complexes from the purple sulfur bacterium Allochromatium vinosum, focusing on the spectral characteristics of the B850 chromophores. Low-temperature B850 absorption and the split B800 band shift blue and red, respectively, at elevated temperatures, revealing isosbestic points. The latter indicates the presence of two (unresolved) conformations of B850 bacteriochlorophylls (BChls), referred to as conformations 1 and 2, and two conformations of B800 BChls, denoted as B800R and B800B...
June 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28520339/reply-by-the-authors-re-artificial-urinary-sphincter-for-urinary-incontinence-after-radical-prostatectomy-a-historical-cohort-from-2004-to-2015
#11
Augusto Cesar Soares Dos Santos, Luíza de Oliveira Rodrigues, Daniela Castelo Azevedo, Lélia Maria de Almeida Carvalho, Mariana Ribeiro Fernandes, Sandra de Oliveira Sapori Avelar, Maria Glória Cruvinel Horta, Silvana Márcia Bruschi Kelles
No abstract text is available yet for this article.
May 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28507611/the-impact-of-extended-typing-on-red-blood-cell-alloimmunization-in-transfused-patients
#12
Tatjana Makarovska-Bojadzieva, Emilija Velkova, Milenka Blagoevska
BACKGROUND: Red blood cell (RBC) alloimmunization is still an actual problem in our transfusion practice. In 2011, in addition to the regular ABO/D blood group typing, phenotyping for Rh (C, c, E, e) and Kell antigens was introduced for blood donors and patients undergoing blood transfusion. Our aim was to evaluate the impact of the extended RBC typing and donor/recipient matching on the incidence of RBC alloimmunization. METHODS: A retrospective comparative study was conducted by reviewing RBC request records for about 36,000 patients transfused with RBC in the period from 2013 to 2015 in comparison to the similar study conducted on 47,000 transfused patients in the period from 2005 to 2008...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28492770/descriptive-study-on-the-evolution-of-hospitalization-costs-for-ambulatory-care-sensitive-conditions-in-brazil-2000-2013
#13
Dayane Kelle de Souza, Sérgio Viana Peixoto
OBJECTIVE: to analyze the proportions of costs of hospitalizations for ambulatory care sensitive conditions (ACSC) in relation to total hospitalization costs funded by the Brazilian National Health System (SUS) in Brazil, in 2000, 2005, 2010 and 2013, according to sex, age and group of causes. METHODS: this is a descriptive study, with data from SUS Hospital Information System (SIH/SUS); the proportion of hospitalization costs for ACSC was estimated in relation to total hospitalization costs...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28489892/exposure-to-maternal-obesogenic-diet-worsens-some-but-not-all-pre-cancer-phenotypes-in-a-murine-genetic-model-of-prostate-cancer
#14
Theresa Okeyo-Owuor, Emily Benesh, Scott Bibbey, Michaela Reid, Jacques Halabi, Siobhan Sutcliffe, Kelle Moley
Prostate cancer research has been predominantly focused on adult exposures and risk factors. However, because the prostate develops during gestation and early life, exposure to external factors, such as obesity, during development could affect the prostate cancer progression in adults. Our previous work demonstrated that exposure to a high fat/high sugar (HF/HS) diet during gestation and until weaning stimulated prostate hyperplasia and altered the Pten/Akt pathway in adult mice fed a normal diet after weaning...
2017: PloS One
https://www.readbyqxmd.com/read/28478703/a-bioreactor-to-identify-the-driving-mechanical-stimuli-of-tissue-growth-and-remodeling
#15
Mathieu A J van Kelle, Pim J A Oomen, Jurgen A Bulsink, Marloes W J T Janssen-van den Broek, Richard G P Lopata, Marcel C M Rutten, Sandra Loerakker, Carlijn V C Bouten
Tissue growth and remodeling are essential processes that should ensure long-term functionality of tissue-engineered (TE) constructs. Even though it is widely recognized that these processes strongly depend on mechanical stimuli, the underlying mechanisms of mechanically induced growth and remodeling are only partially understood. It is generally accepted that cells sense mechanical changes and respond by altering their surroundings, by means of extracellular matrix growth and remodeling, in an attempt to return to a certain preferred mechanical homeostatic state...
June 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28466636/versatile-molecular-silver-ink-platform-for-printed-flexible-electronics
#16
Arnold J Kell, Chantal Paquet, Olga Mozenson, Iden Djavani-Tabrizi, Bhavana Deore, Xiangyang Liu, Gregory P Lopinski, Robert James, Khelifa Hettak, Jafar Shaker, Adrian Momciu, Julie Ferrigno, Olivier Ferrand, Jian Xiong Hu, Sylvie Lafrenière, Patrick R L Malenfant
A silver molecular ink platform formulated for screen, inkjet, and aerosol jet printing is presented. A simple formulation comprising silver neodecanoate, ethyl cellulose, and solvent provides improved performance versus that of established inks, yet with improved economics. Thin, screen-printed traces with exceptional electrical (<10 mΩ/□/mil or 12 μΩ·cm) and mechanical properties are achieved following thermal or photonic sintering, the latter having never been demonstrated for silver-salt-based inks...
May 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28459521/breast-cancer-stem-like-cells-can-promote-metastasis-by-activating-platelets-and-down-regulating-antitumor-activity-of-natural-killer-cells
#17
Shuo Wang, Ying Zhang, Weihong Cong, Jie Liu, Yuren Zhang, Huiting Fan, Yonggang Xu, Hongsheng Lin
OBJECTIVE: To investigate whether cancer stem cells (CSCs) more efficiently activating platelets and evading immune surveillance than non-CSCs thus promoting metastasis. METHODS: We enriched and identified sphere-forming cells (SFCs) and coincubated washed platelets with several platelet activators including collagen, 4T1 and SFCs. Platelet-coating tumor cells, platelet activation and TGF-β1 release were analyzed. Then natural kell cells (NK) were incubated with supernatants of different activated platelet samples what we called sample release (SR)...
August 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/28457201/how-are-sexual-health-clinics-in-england-managing-men-who-have-sex-with-men-who-refuse-to-be-tested-for-hiv
#18
Juan Hoyos Miller, Emily Clarke, Raj Patel, Philip Kell, Monica Desai, Anthony Nardone
The aim of this study was to ascertain the existence of written policies and common clinical practices in sexual health clinics in England for the management of men who have sex with men who refuse to test for HIV. All sexual health clinics in England ( n = 223) were invited to complete an online questionnaire in August-September 2014. The questionnaire covered the four domains of clinic policies, management practices, training and monitoring. We assess differences by region. Overall, 92 clinics participated...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28438607/obesity-exposed-oocytes-accumulate-and-transmit-damaged-mitochondria-due-to-an-inability-to-activate-mitophagy
#19
Anna L Boudoures, Jessica Saben, Andrea Drury, Suzanne Scheaffer, Zeel Modi, Wendy Zhang, Kelle H Moley
Mitochondria are the most prominent organelle in the oocyte. Somatic cells maintain a healthy population of mitochondria by degrading damaged mitochondria via mitophagy, a specialized autophagy pathway. However, evidence from previous work investigating the more general macroautophagy pathway in oocytes suggests that mitophagy may not be active in the oocyte. This would leave the vast numbers of mitochondria - poised to be inherited by the offspring - vulnerable to damage. Here we test the hypothesis that inactive mitophagy in the oocyte underlies maternal transmission of dysfunctional mitochondria...
April 21, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28438343/developmental-and-transmittable-origins-of-obesity-associated-health-disorders
#20
REVIEW
Arin K Oestreich, Kelle H Moley
The current global obesity pandemic is clearly linked to both the increasing prevalence of, and preference for, foods high in calories, specifically fat and sucrose, and declining levels of daily physical activity. A less commonly discussed possible explanation is that risk of obesity begins in utero as a result of developmental plasticity during early life. This idea fits into the broader Developmental Origins of Health and Diseases (DOHAD) hypothesis, which holds that stressful in utero exposure manifests as disease in adulthood...
April 21, 2017: Trends in Genetics: TIG
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