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Developmental Toxicity

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https://www.readbyqxmd.com/read/29776592/response-to-metals-treatment-of-fra1-a-member-of-the-ap-1-transcription-factor-family-in-p-lividus-sea-urchin-embryos
#1
Roberta Russo, Rosa Bonaventura, Marco Chiaramonte, Caterina Costa, Valeria Matranga, Francesca Zito
Lithium (Li), Nickel (Ni), and Zinc (Zn) are metals normally present in the seawater, although they can have adverse effects on the marine ecosystem at high concentrations by interfering with many biological processes. These metals are toxic for sea urchin embryos, affecting their morphology and developmental pathways. In particular, they perturb differently the correct organization of the embryonic axes (animal-vegetal, dorso-ventral): Li is a vegetalizing agent and Ni disrupts the dorso-ventral axis, while Zn has an animalizing effect...
May 5, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29775928/tributyltin-impaired-reproductive-success-in-female-zebrafish-through-disrupting-oogenesis-reproductive-behaviors-and-serotonin-synthesis
#2
Wei-Yang Xiao, Ying-Wen Li, Qi-Liang Chen, Zhi-Hao Liu
Tributyltin (TBT), an organotin acting as aromatase (Cyp19a1) inhibitor, has been found to disrupt gametogenesis and reproductive behaviors in several fish species. However, few studies addressing the mechanisms underlying the impaired gametogenesis and reproduction have been reported. In this study, female adults of zebrafish (Danio rerio) were continuously exposed to two nominal concentrations of TBT (100 and 500 ng/L, actual concentrations: 90.8 ± 1.3 ng/L and 470.3 ± 2.7 ng/L, respectively) for 28 days...
May 12, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29765770/persistent-6-oh-bde-47-exposure-impairs-functional-neuronal-maturation-and-alters-expression-of-neurodevelopmentally-relevant-chromatin-remodelers
#3
Robert G Poston, Carissa J Dunn, Pushpita Sarkar, Ramendra N Saha
Polybrominated diphenyl ethers (PBDEs) are a pervasive class of brominated flame retardants that are present in the environment at particularly high levels, especially in the United States. Their environmental stability, propensity for bioaccumulation, and known potential for neurotoxicity has evoked interest regarding their effects on the developing nervous system. Exposure to PBDEs has been strongly associated with neurodevelopmental disorders. However, the details of their mechanistic roles in such disorders are incompletely understood...
January 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29760143/developmental-sensitivity-in-schistosoma-mansoni-to-puromycin-to-establish-drug-selection-of-transgenic-schistosomes
#4
Hong-Bin Yan, Michael J Smout, Chuan Ju, Anne E Folley, Danielle E Skinner, Victoria H Mann, Alex Loukas, Wei Hu, Paul J Brindley, Gabriel Rinaldi
Schistosomiasis is considered the most important disease caused by helminth parasites, in terms of morbidity and mortality. Tools to facilitate gain- and loss- of-function approaches can be expected to precipitate the discovery of novel interventions, and drug selection of transgenic schistosomes would facilitate the establishment of stable lines of engineered parasites. Sensitivity of developmental stages of schistosomes to the aminonucleoside antibiotic puromycin was investigated. For the schistosomulum and sporocyst stages, viability was quantified by fluorescence microscopy following dual staining with fluorescein diacetate and propidium iodine...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29758875/thifluzamide-affects-lipid-metabolism-in-zebrafish-danio-reio
#5
Yang Yang, Fengshou Dong, Xingang Liu, Jun Xu, Xiaohu Wu, Suzhen Qi, Wenxian Liu, Yongquan Zheng
Thifluzamide, a succinate dehydrogenase inhibitor (SDHI) fungicide, has been widely used in rice fields throughout the world and causes hepatotoxicity in zebrafish (Danio reio). This study was conducted to investigate the effect of thifluzamide on lipid metabolism in zebrafish after exposure to a control or, 0.019, 0.19, or 1.90mg/L thifluzamide for 28days. Following exposure, pathological changes in the liver were evaluated. Total cholesterol (TCHO) level, and triglyceride (TG) levels as well as hepatic lipase (HL), lipoprotein lipase (LPL), fatty acid synthetase (FAS) and carnitine palmitoyltransferase (CPT-I) activities were measured...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29758497/growth-and-recovery-of-zebrafish-embryos-after-developmental-exposure-to-raw-and-ozonated-oil-sands-process-affected-water
#6
Danielle D Lyons, Christie Morrison, Danielle A Philibert, Mohamed Gamal El-Din, Keith B Tierney
Due to the increasing volume of oil sands process-affect water (OSPW) and its toxicity to aquatic organisms, it is important to fully understand its effects and study remediation processes that will enable its release to the environment. Ozone treatment is currently being considered as a tool to expedite remediation, as it is known to degrade toxic organic compounds present in OSPW. In this study, we aimed to measure the effects of OSPW exposure on the growth, development and recovery of zebrafish (Danio rerio) embryos...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29753971/development-and-validation-of-an-hplc-ms-ms-method-for-the-detection-of-ketamine-in-calliphora-vomitoria-l-diptera-calliphoridae
#7
Paola A Magni, Marco Pazzi, Jessica Droghi, Marco Vincenti, Ian R Dadour
Entomotoxicology is a branch of forensic entomology that studies the detection of drugs or other toxic substances from insects developing on the decomposing tissues of a human corpse or animal carcass. Entomotoxicology also investigates the effects of these substances on insect development, survival and morphology to provide an estimation of the minimum time since death. Ketamine is a medication mainly used for starting and maintaining anesthesia. In recent years ketamine has also been used as a recreational drug, and occasionally as a sedating drug to facilitate sexual assault...
May 3, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29753929/best-practices-for-developmental-toxicity-assessment-for-classification-and-labeling
#8
George Daston, Aldert Piersma, Leonello Attias, Manon Beekhuijzen, Connie Chen, Jennifer Foreman, Nina Hallmark, Isabelle Leconte
Many chemicals are going through a hazard-based classification and labeling process in Europe. Because of the significant public health implications, the best science must be applied in assessing developmental toxicity data. The European Teratology Society and Health and Environmental Sciences Institute co-organized a workshop to consider best practices, including data quality and consistency, interpretation of developmental effects in the presence of maternal toxicity, human relevance of animal data, and limits of chemical classes...
May 10, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29753751/the-aryl-hydrocarbon-receptor-is-indispensable-for-dioxin-induced-defects-in-sexually-dimorphic-behaviors-due-to-the-reduction-in-fetal-steroidogenesis-of-the-pituitary-gonadal-axis-in-rats
#9
Yukiko Hattori, Tomoki Takeda, Arisa Nakamura, Kyoko Nishida, Yuko Shioji, Haruki Fukumitsu, Hideyuki Yamada, Yuji Ishii
Many forms of the toxic effects produced by dioxins and related chemicals take place following activation of the aryl hydrocarbon receptor (AHR). Our previous studies have demonstrated that treating pregnant rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic dioxin, attenuates the pituitary expression of gonadotropins to reduce testicular steroidogenesis during the fetal stage, resulting in the impairment of sexually-dimorphic behaviors after the offspring reach maturity. To investigate the contribution of AHR to these disorders, we examined the effects of TCDD on AHR-knockout (AHR-KO) Wistar rats...
May 10, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29751403/development-of-a-high-throughput-in-vivo-screening-platform-for-particulate-matter-exposures
#10
Courtney Roper, Staci L Massey Simonich, Robert L Tanguay
Particulate matter (PM) exposure is a public health burden with poorly understood health effect mechanisms and lacking an efficient model to compare the vast diversity of PM exposures. Zebrafish (Danio rerio) are amenable to high-throughput screening (HTS), but few studies have investigated PM toxicity in zebrafish, despite the multitude of advantages. To develop standardized exposure procedures, the urban PM standard reference material (SRM) 1649b was used to systematically determine sample preparation methods, design experimental controls, determine concentration ranges and evaluation procedures...
April 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29751329/determination-of-metals-and-pharmaceutical-compounds-released-in-hospital-wastewater-from-toluca-mexico-and-evaluation-of-their-toxic-impact
#11
Itzayana Pérez-Alvarez, Hariz Islas-Flores, Leobardo Manuel Gómez-Oliván, Damià Barceló, Miren López De Alda, Sandra Pérez Solsona, Livier Sánchez-Aceves, Nely SanJuan-Reyes, Marcela Galar-Martínez
Due to the activities inherent to medical care units, the hospital effluent released contains diverse contaminants such as tensoactives, disinfectants, metals, pharmaceutical products and chemical reagents, which are potentially toxic to the environment since they receive no treatment or are not effectively removed by such treatment before entering the drain. They are incorporated into municipal wastewater, eventually entering water bodies where they can have harmful effects on organisms and can result in ecological damage...
May 8, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29748567/a-rapid-and-nondestructive-protocol-for-whole-mount-bone-staining-of-small-fish-and-xenopus
#12
Hiromi Sakata-Haga, Maimi Uchishiba, Hiroki Shimada, Tsuyoshi Tsukada, Mayumi Mitani, Tomohiro Arikawa, Hiroki Shoji, Toshihisa Hatta
Here we propose a new protocol for whole-mount bone staining, which allows the rapid preparation of highly cleared and nondestructive specimens. It only takes 3 days to complete whole procedure for small vertebrates, such as medaka, zebrafish, and Xenopus frogs. In this procedure, we used a newly developed fixative containing formalin, Triton X-100, and potassium hydroxide, which allows the fixation, decolorization, and transparentization of specimens at the same time. A bone staining solution containing alizarin red S with ethylene glycol and a clearing solution containing Tween 20 and potassium hydroxide also contributed the specificity and swiftness of this new system...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29745611/-effect-of-cryoprotectant-removal-by-microfluidic-chip-on-developmental-capacity-of-oocytes
#13
Xingyue Yi, Xinli Zhou, Yun Yang, Jianjun Dai, Defu Zhang
In order to reduce osmotic damage and chemical toxicity of cryoprotectants (CPA) to oocytes during unloading process, the microfluidic chip was used to remove CPA from porcine MⅡ oocytes in this study. Firstly, the effects of unloading time, composition and concentration of diluting solutions of microfluidic method on survival rate and developmental capacity of oocytes were studied, then microfluidic method was compared with traditional one-step and two-step CPA unloading protocols. The results showed that when the total time is 8 minutes, the survival rate and morula rate of oocytes treated with microfluidic method could achieve 95...
February 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29743688/lethal-trap-created-by-adaptive-evolutionary-response-to-an-exotic-resource
#14
Michael C Singer, Camille Parmesan
Global transport of organisms by humans provides novel resources to wild species, which often respond maladaptively. Native herbivorous insects have been killed feeding on toxic exotic plants, which acted as 'ecological traps'1-4 . We document a novel 'eco-evolutionary trap' stemming from the opposite effect; that is, high fitness on an exotic resource despite lack of adaptation to it. Plantago lanceolata was introduced to western North America by cattle-ranching. Feeding on this exotic plant released a large, isolated population of the native butterfly Euphydryas editha from a longstanding trade-off between maternal fecundity and offspring mortality...
May 2018: Nature
https://www.readbyqxmd.com/read/29741810/quantitative-proteomics-study-reveals-changes-in-the-molecular-landscape-of-human-embryonic-stem-cells-with-impaired-stem-cell-differentiation-upon-exposure-to-titanium-dioxide-nanoparticles
#15
Lei Pan, Yew Mun Lee, Teck Kwang Lim, Qingsong Lin, Xiuqin Xu
The increasing number of nanoparticles (NPs) being used in various industries has led to growing concerns of potential hazards that NP exposure can incur on human health. However, its global effects on humans and the underlying mechanisms are not systemically studied. Human embryonic stem cells (hESCs), with the ability to differentiate to any cell types, provide a unique system to assess cellular, developmental, and functional toxicity in vitro within a single system highly relevant to human physiology. Here, the quantitative proteomics approach is adopted to evaluate the molecular consequences of titanium dioxide NPs (TiO2 NPs) exposure in hESCs...
May 9, 2018: Small
https://www.readbyqxmd.com/read/29741588/paternal-developmental-toxicant-exposure-is-associated-with-epigenetic-modulation-of-sperm-and-placental-pgr-and-igf2-in-a-mouse-model
#16
Tianbing Ding, Shilpa Mokshagundam, Paolo F Rinaudo, Kevin G Osteen, Kaylon L Bruner-Tran
Preterm birth (PTB), parturition prior to 37 weeks gestation, is the leading cause of neonatal mortality. The causes of spontaneous PTB are poorly understood; however, recent studies suggest this condition may arise as a consequence of the parental fetal environment. Specifically, we previously demonstrated that developmental exposure of male mice (F1 animals) to the environmental endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was associated with reduced sperm quantity/quality in adulthood and control female partners frequently delivered preterm...
May 7, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29738950/ocean-acidification-modulates-the-incorporation-of-radio-labeled-heavy-metals-in-the-larvae-of-the-mediterranean-sea-urchin-paracentrotus-lividus
#17
Narimane Dorey, Sophie Martin, François Oberhänsli, Jean-Louis Teyssié, Ross Jeffree, Thomas Lacoue-Labarthe
The marine organisms which inhabit the coastline are exposed to a number of anthropogenic pressures that may interact. For instance, the accumulation of toxic metals present in coastal waters is expected to be modified by ocean acidification through e.g. changes in physiological performance and/or elements availability. Changes in bioaccumulation due to lowering pH are likely to be differently affected depending on the nature (essential vs. non-essential) and speciation of each element. The Mediterranean is of high concern for possible cumulative effects due to strong human influences on the coastline...
May 5, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29737997/predicting-the-impact-of-structural-diversity-on-the-performance-of-nanodiamond-drug-carriers
#18
REVIEW
A S Barnard
Diamond nanoparticles (nanodiamonds) are unique among carbon nanomaterials, and are quickly establishing a niché in the biomedical application domain. Nanodiamonds are non-toxic, amenable to economically viable mass production, and can be interfaced with a variety of functional moieties. However, developmental challenges arise due to the chemical complexity and structural diversity inherent in nanodiamond samples. Nanodiamonds present a narrow, but significant, distribution of sizes, a dizzying array of possible shapes, and a complicated surface containing aliphatic and aromatic carbon...
May 8, 2018: Nanoscale
https://www.readbyqxmd.com/read/29734617/blood-mercury-lead-and-cadmium-levels-and-determinants-of-exposure-among-newcomer-south-and-east-asian-women-of-reproductive-age-living-in-vancouver-canada
#19
Linda Dix-Cooper, Tom Kosatsky
BACKGROUND: Biomarkers of the reproductive and neuro-developmental toxicants mercury (Hg), lead (Pb) and cadmium (Cd) have been found at higher concentrations in women born outside Canada than in Canadian-born women. We measured blood Hg, Pb and Cd in women ages 19 to 45years living in greater Vancouver (Canada) within five years of their arrival from South Asia (India) or East Asia (mainland China, Hong Kong and Taiwan) and related their biomarker concentration levels with exposures and behaviors since their coming to Canada...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29733941/anti-quorum-sensing-activity-toxicity-in-zebrafish-danio-rerio-embryos-and-phytochemical-characterization-of-trapa-natans-leaf-extracts
#20
Ivana Aleksic, Petar Ristivojevic, Aleksandar Pavic, Ivana Radojević, Ljiljana R Čomić, Branka Vasiljevic, Dejan Opsenica, Dušanka Milojković-Opsenica, Lidija Senerovic
ETHNOPHARMACOLOGICAL RELEVANCE: Trapa natans L. (water chestnut or water caltrop) is a widespread aquatic plant, which has been cultivated for food and traditional medicine since ancient times. Pharmacological studies showed that water chestnut exhibits the wide range of biological activities, such as antimicrobial, antioxidative, analgesic, anti-inflammatory, as well as antiulcer. AIMOF THE STUDY: Evaluation of anti-virulence potential and toxicity of T. natans methanol (TnM), acetone (TnA) and ethyl acetate (TnEA) leaf extracts...
May 4, 2018: Journal of Ethnopharmacology
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