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https://www.readbyqxmd.com/read/27891785/editorial-brain-malformation-surveillance-in-the-zika-era
#1
EDITORIAL
Edwin Trevathan
The current surveillance systems for congenital microcephaly are necessary to monitor the impact of Zika virus (ZIKV) on the developing human brain, as well as the ZIKV prevention efforts. However, these congenital microcephaly surveillance systems are insufficient. Abnormalities of neuronal differentiation, development and migration may occur among infants with normal head circumference who have intrauterine exposure to ZIKV. Therefore, surveillance for congenital microcephaly does not ascertain many of the infants seriously impacted by congenital ZIKV infection...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27891246/two-headed-mutants-of-the-lamprey-a-basal-vertebrate
#2
Daichi G Suzuki
BACKGROUND: This is the first report of two-headed (bicephaly) lamprey twins. Although lampreys sit at a crucial phylogenetic position, there are only a few reports on their teratology and developmental abnormalities. RESULTS: Two-headed mutants were obtained by artificial fertilization in the laboratory as spontaneous occurrences. All mutants were derived from single fertilizations using single male and female gametes, suggestive of a genetic background. The anterio-posterior position of the axonal bifurcation and symmetricity varied in each mutant...
2016: Zoological Letters
https://www.readbyqxmd.com/read/27884274/50-years-ago-in-the-journal-of-pediatrics-dysmorphology-teratology
#3
Jennifer A Accardo
No abstract text is available yet for this article.
December 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27883261/prevention-of-neural-tube-defects-in-lrp-mutant-mouse-embryos-by-folic-acid-supplementation
#4
Julia A Sabatino, Bethany A Stokes, Irene E Zohn
BACKGROUND: Neural tube defects (NTDs) are among the most common structural birth defects in humans and are caused by the complex interaction of genetic and environmental factors. Periconceptional supplementation with folic acid can prevent NTDs in both mouse models and human populations. A better understanding of how genes and environmental factors interact is critical toward development of rational strategies to prevent NTDs. Low density lipoprotein-related protein 2 (Lrp2) is involved in endocytosis of the folic acid receptor among numerous other nutrients and ligands...
November 24, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27876346/withdrawn-45th-annual-meeting-of-the-european-teratology-society
#5
(no author information available yet)
This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
July 14, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27851994/pregnancy-outcomes-after-maternal-varenicline-use-analysis-of-surveillance-data-collected-by-the-european-network-of-teratology-information-services
#6
J L Richardson, S Stephens, L M Yates, O Diav-Citrin, J Arnon, D Beghin, A Kayser, D Kennedy, D Cupitt, B Te Winkel, M Peltonen, Y C Kaplan, S H L Thomas
: Varenicline is a smoking cessation aid for which limited data exist concerning safety during human pregnancy. This multicentre prospective observational comparative cohort study was undertaken using surveillance data collected by the European Network of Teratology Information Services. The study sample consisted of 89 varenicline exposed pregnancies and two matched comparator groups; 267 non-teratogen exposed (NTE) controls and 78 exposed to nicotine replacement therapy or bupropion (NRT/B) for smoking cessation...
November 13, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27846760/outcome-of-breastfed-infants-following-post-partum-methylergonovine-treatment
#7
Oded Gilad, Paul Merlob, Bracha Stahl, Noa Averbuch, Gil Klinger
OBJECTIVE: To evaluate maternal and breastfed infant's outcome following post-partum maternal use of methylergonovine. METHODS: A prospective, controlled observational study design was used. Mothers who contacted Beilinson Teratology Information Service (BELTIS) were followed by phone interview. Data on lactation, neonatal symptoms and outcomes at the age of 1-3 years were obtained. Mothers' breastfeeding while treated with methylergonovine and their infants were compared to a matched control group of breastfeeding mothers using a drug known to be safe during lactation (amoxicillin)...
November 16, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27801974/does-arsenic-increase-the-risk-of-neural-tube-defects-among-a-highly-exposed-population-a-new-case-control-study-in-bangladesh
#8
Maitreyi Mazumdar
BACKGROUND: Neural tube defects are debilitating birth defects that occur when the developing neural plate fails to close in early gestation. Arsenic induces neural tube defects in animal models, but whether environmental arsenic exposure increases risk of neural tube defects in humans is unknown. METHODS: We describe a new case-control study in Bangladesh, a country currently experiencing an epidemic of arsenic poisoning through contaminated drinking water. We plan to understand how arsenic influences risk of neural tube defects in humans through mechanisms that include disruption of maternal glucose and folate metabolism, as well as epigenetic effects...
November 1, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27785824/a-core-syllabus-for-the-teaching-of-embryology-and-teratology-to-medical-students
#9
Francis A Fakoya, Elpida Emmanouil-Nikoloussi, Deepak Sharma, Bernard J Moxham
Clinical relevance in the teaching of biomedical sciences within health care courses presupposes that there is internationally agreed core material within the curricula. However, with the exception of a syllabus for neuroanatomy and gross anatomy of the head and neck for medical students, core syllabuses within many of the specialised anatomical sciences have yet to be developed. The International Federation of Associations of Anatomists aims to formulate internationally accepted core syllabuses for all anatomical sciences disciplines initially using Delphi Panels that comprise anatomists, scientists and clinicians who evaluate syllabus content...
October 27, 2016: Clinical Anatomy
https://www.readbyqxmd.com/read/27784201/iodine-supplementation-in-women-during-preconception-pregnancy-and-lactation-current-clinical-practice-by-u-s-obstetricians-and-midwives
#10
Simone De Leo, Elizabeth N Pearce, Lewis E Braverman
BACKGROUND: Iodine deficiency is a major public health problem throughout the world, especially for pregnant women, and it is considered the most common cause of preventable intellectual impairment. In the United States, iodine status in pregnant women is considered mildly deficient. Therefore, the Endocrine Society, the American Thyroid Association, the Teratology Society, and the American Academy of Pediatrics recommend that women receive prenatal vitamins containing 150 µg of iodine daily during preconception, pregnancy, and lactation...
October 26, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27708197/influence-of-study-design-on-developmental-and-reproductive-toxicology-study-outcomes
#11
Paul M D Foster
Regulatory studies of developmental and reproductive toxicity (DART) studies have remained largely unchanged for decades, with exposures occurring at various phases of the reproductive cycle and toxicity evaluations at different ages/times depending on the study purpose. The National Toxicology Program has conducted studies examining the power to detect adverse effects where there is a prenatal exposure, but evaluations occur postnatally. In these studies, examination is required of only 1 male and female pup from each litter beyond weaning...
October 5, 2016: Toxicologic Pathology
https://www.readbyqxmd.com/read/27663874/relationships-for-mercury-and-selenium-in-muscle-and-ova-of-gravid-freshwater-fish
#12
David B Donald
At high concentrations, mercury (Hg) is toxic to vertebrates, causing neurological, behavioral, and teratological dysfunction. Selenium (Se) not only is an essential element but also has a high affinity for Hg, binding to organic methyl mercury at a molar ratio of Se/Hg of 1:1. Ratios of <1 increase risk of Hg toxicity. For gravid fish, low concentrations of Se in ova could increase potential for Hg toxicity, compromising embryonic development and fitness of fry. Mercury and selenium concentrations and ratios were investigated in the muscle and ovaries of six species from five families of fish to assess potential for risk to ecological fitness...
December 0: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27634006/the-56th-annual-meeting-of-the-japanese-teratology-society-new-developments-and-future-perspectives-of-teratology-study-translational-study-to-link-teratology-to-nutrition-overview
#13
https://www.readbyqxmd.com/read/27630750/pregnancy-and-lactation-advice-how-does-australian-product-information-compare-with-established-information-resources
#14
Emma Brown, Elizabeth Hotham, Neil Hotham
BACKGROUND: Product information is a popular medicines information resource; however, there is some evidence that its pregnancy and lactation information is overconservative, which can lead to inadequate treatment of pregnant and lactating women. METHODS: A thorough analysis of pregnancy and lactation information within Australian Product Information and Consumer Medicines Information was performed. The statements within these resources were compared with established clinical resources: Australian Medicines Handbook, Therapeutic Guidelines, South Australian Perinatal Practice Guidelines, Organization of Teratology Information Specialists, LactMed, Motherisk and the Pregnancy and Breastfeeding Medicines Guide published by the Royal Women's Hospital Melbourne...
September 2016: Obstetric Medicine
https://www.readbyqxmd.com/read/27589342/consistency-of-maternal-telephone-administration-of-the-asthma-control-test-using-postpartum-recall-compared-to-repeated-measures-during-pregnancy
#15
Ronghui Xu, Mofei Li, Diana L Johnson, Yunjun Luo, Christina D Chambers
BACKGROUND: Suboptimal asthma control during pregnancy may impact perinatal outcomes. U.S. guidelines recommend questionnaires to assess asthma control including the Asthma Control Test (ACT). It is unknown in a research setting to what extent recall differs by the time between symptom occurrence and the administration of the questionnaire. METHODS: Between 2009 - 2014, 196 pregnant asthmatic women were recruited by the Organization of Teratology Information Specialists (OTIS) MotherToBaby Pregnancy Studies...
September 2, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27567698/prenatal-cannabis-exposure-the-first-hit-to-the-endocannabinoid-system
#16
Kimberlei A Richardson, Allison K Hester, Gabrielle L McLemore
As more states and countries legalize medical and/or adult recreational marijuana use, the incidences of Prenatal Cannabis Exposure (PCE) will likely increase. While young people increasingly view marijuana as innocuous, marijuana preparations have been growing in potency in recent years, potentially creating global clinical, public health, and workforce concerns. Unlike fetal alcohol spectrum disorder, there is no phenotypic syndrome associated with PCE. There is also no preponderance of evidence that PCE causes lifelong cognitive, behavioral, or functional abnormalities, and/or susceptibility to subsequent addiction...
August 24, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27540704/neonatal-experiences-with-ethanol-intoxication-modify-respiratory-and-thermoregulatory-plasticity-and-affect-subsequent-ethanol-intake-in-rats
#17
María Belén Acevedo, Ana Fabiola Macchione, Florencia Anunziata, Olga Beatriz Haymal, Juan Carlos Molina
Different studies have focused on the deleterious consequences of binge-like or chronic exposure to ethanol during the brain growth spurt period (third human gestational trimester) that in the rat corresponds to postnatal days (PDs) 3-10. The present study analyzed behavioral and physiological disruptions caused by relatively brief binge-like exposures (PDs 3, 5, and 7) with an ethanol dose lower (3.0 g/kg) than those frequently employed to examine teratological effects during this stage in development. At PD 9, pups were exposed to ethanol doses ranging between ...
August 19, 2016: Developmental Psychobiology
https://www.readbyqxmd.com/read/27536042/effect-of-endosulfan-on-immunological-competence-of-layer-birds
#18
P P Singh, Ashok Kumar, R S Chauhan, P K Pankaj
AIM: The present study was aimed to investigate the immunological competence of endosulfan insecticide after limited oral administration in White Leghorn layer chickens. MATERIALS AND METHODS: A total of 20 White Leghorn birds were given endosulfan in drinking water at 30 ppm/bird/day (no observable effect level dose) for a period of 3-months. Immune competence status of layer birds and chicks hatched from endosulfan offered birds were estimated at 15-day interval in layer birds and at monthly interval in chicks using immunological, biochemical parameters, and teratological estimates...
July 2016: Veterinary World
https://www.readbyqxmd.com/read/27535157/in-ovo-toxico-teratological-effects-of-aluminum-on-embryonic-chick-heart-and-vascularization
#19
Reda H ElMazoudy, Gamal A Bekhet
In spite of extensive research and persistent arguments, the mechanism of aluminum (Al) toxicity is still obscure. It is firmly established that aluminum is a potent neurotoxicant. So, the aim based on is aluminum damage chicken heart, as well as the vitelline circulation. In the first 3 days of incubation (D0-D2), 1.0, 2.0, or 4.0 mg aluminum chloride/0.3 ml avian saline was injected into the center of each viable fertilized egg yolk (AL1, AL2, and AL3 groups, respectively). Control eggs were either uninjected (AL0) or injected (ALS, 0...
August 18, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27511269/association-between-irf6-and-8q24-polymorphisms-and-nonsyndromic-cleft-lip-with-or-without-cleft-palate-systematic-review-and-meta-analysis
#20
Kachin Wattanawong, Sasivimol Rattanasiri, Mark McEvoy, John Attia, Ammarin Thakkinstian
BACKGROUND: We conducted a systematic review and meta-analysis of interferon regulatory factor 6 and 8q24 polymorphisms with nonsyndromic cleft lip with/without cleft palate (NSCL/P). METHODS: Data extraction was independently performed by two reviewers. Genotypic effects of four polymorphisms from 31 studies were pooled separately by ethnicity using a mixed-effect logit model with accounting for heterogeneity. RESULTS: For rs2235371, AA and GA carried, respectively, 51% (95% confidence interval [CI], 37%-61%) and 42% (95% CI, 32%-50%) lower risks of NSCL/P than GG genotypes in Asians, but these genotypes were not significant in Caucasians...
September 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
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