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Teratology

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https://www.readbyqxmd.com/read/28118300/early-application-of-the-ponseti-casting-technique-for-clubfoot-correction-in-sick-infants-at-the-neonatal-intensive-care-unit
#1
Ehud Lebel, Eliraz Weinberg, Tamar M Berenstein-Weyel, Ruben Bromiker
The treatment of congenital clubfoot has been changing rapidly since the mid-1990s with the worldwide use of the Ponseti method for serial casting and limited operative interventions. This method was first applied for isolated clubfeet and later on for other types of clubfoot (teratologic, residual, and neurogenic). Premature babies sustaining clubfoot commonly suffer from additional congenital and acquired medical problems. These may postpone clubfoot management until urgent issues are resolved. The current study describes early initiation of treatment of clubfoot in premature babies at the neonatal intensive care unit (NICU) and their outcomes...
March 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28008752/high-levels-of-iron-supplementation-prevents-neural-tube-defects-in-the-fpn1-ffe-mouse-model
#2
Bethany A Stokes, Julia A Sabatino, Irene E Zohn
BACKGROUND: Periconception maternal nutrition and folate in particular are important factors influencing the incidence of neural tube defects (NTDs). Many but not all NTDs are prevented by folic acid supplementation and there is a pressing need for additional strategies to prevent these birth defects. Other micronutrients such as iron are potential candidates, yet a clear role for iron deficiency in contributing to NTDs is lacking. Our previous studies with the flatiron (ffe) mouse model of Ferroportin1 (Fpn1) deficiency suggest that iron is required for neural tube closure and forebrain development raising the possibility that iron supplementation could prevent NTDs...
December 23, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/28007609/editorial-updates-in-teratology
#3
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
January 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27915015/who-seeks-teratology-information-service-s-advice-assessing-the-risk-of-selection-bias-in-observational-cohort-studies-on-drug-risks-in-pregnancy
#4
Evelin Beck, Anna Lechner, Christof Schaefer
All women of reproductive age should have access to Teratology Information Services (TIS). Observational cohort studies based on TIS data are one of the most important sources for risk characterization of drugs during pregnancy. A selection in TIS populations towards higher socioeconomic level would compromise the TIS' goal of health prevention and the quality of research. The aim of this study is to investigate in which respect Berlin TIS enquirers are different from the general female population of reproductive age in Germany...
November 30, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27891785/editorial-brain-malformation-surveillance-in-the-zika-era
#5
EDITORIAL
Edwin Trevathan
The current surveillance systems for congenital microcephaly are necessary to monitor the impact of Zika virus (ZIKV) on the developing human brain, as well as the ZIKV prevention efforts. However, these congenital microcephaly surveillance systems are insufficient. Abnormalities of neuronal differentiation, development and migration may occur among infants with normal head circumference who have intrauterine exposure to ZIKV. Therefore, surveillance for congenital microcephaly does not ascertain many of the infants seriously impacted by congenital ZIKV infection...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27891246/two-headed-mutants-of-the-lamprey-a-basal-vertebrate
#6
Daichi G Suzuki
BACKGROUND: This is the first report of two-headed (bicephaly) lamprey twins. Although lampreys sit at a crucial phylogenetic position, there are only a few reports on their teratology and developmental abnormalities. RESULTS: Two-headed mutants were obtained by artificial fertilization in the laboratory as spontaneous occurrences. All mutants were derived from single fertilizations using single male and female gametes, suggestive of a genetic background. The anterio-posterior position of the axonal bifurcation and symmetricity varied in each mutant...
2016: Zoological Letters
https://www.readbyqxmd.com/read/27884274/50-years-ago-in-the-journal-of-pediatrics-dysmorphology-teratology
#7
Jennifer A Accardo
No abstract text is available yet for this article.
December 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27883261/prevention-of-neural-tube-defects-in-lrp-mutant-mouse-embryos-by-folic-acid-supplementation
#8
Julia A Sabatino, Bethany A Stokes, Irene E Zohn
BACKGROUND: Neural tube defects (NTDs) are among the most common structural birth defects in humans and are caused by the complex interaction of genetic and environmental factors. Periconceptional supplementation with folic acid can prevent NTDs in both mouse models and human populations. A better understanding of how genes and environmental factors interact is critical toward development of rational strategies to prevent NTDs. Low density lipoprotein-related protein 2 (Lrp2) is involved in endocytosis of the folic acid receptor among numerous other nutrients and ligands...
November 24, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27876346/withdrawn-45th-annual-meeting-of-the-european-teratology-society
#9
(no author information available yet)
This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
July 14, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27851994/pregnancy-outcomes-after-maternal-varenicline-use-analysis-of-surveillance-data-collected-by-the-european-network-of-teratology-information-services
#10
J L Richardson, S Stephens, L M Yates, O Diav-Citrin, J Arnon, D Beghin, A Kayser, D Kennedy, D Cupitt, B Te Winkel, M Peltonen, Y C Kaplan, S H L Thomas
: Varenicline is a smoking cessation aid for which limited data exist concerning safety during human pregnancy. This multicentre prospective observational comparative cohort study was undertaken using surveillance data collected by the European Network of Teratology Information Services. The study sample consisted of 89 varenicline exposed pregnancies and two matched comparator groups; 267 non-teratogen exposed (NTE) controls and 78 exposed to nicotine replacement therapy or bupropion (NRT/B) for smoking cessation...
November 13, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27846760/outcome-of-breastfed-infants-following-post-partum-methylergonovine-treatment
#11
Oded Gilad, Paul Merlob, Bracha Stahl, Noa Averbuch, Gil Klinger
OBJECTIVE: To evaluate maternal and breastfed infant's outcome following post-partum maternal use of methylergonovine. METHODS: A prospective, controlled observational study design was used. Mothers who contacted Beilinson Teratology Information Service (BELTIS) were followed by phone interview. Data on lactation, neonatal symptoms and outcomes at the age of 1-3 years were obtained. Mothers' breastfeeding while treated with methylergonovine and their infants were compared to a matched control group of breastfeeding mothers using a drug known to be safe during lactation (amoxicillin)...
November 16, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27801974/does-arsenic-increase-the-risk-of-neural-tube-defects-among-a-highly-exposed-population-a-new-case-control-study-in-bangladesh
#12
Maitreyi Mazumdar
BACKGROUND: Neural tube defects are debilitating birth defects that occur when the developing neural plate fails to close in early gestation. Arsenic induces neural tube defects in animal models, but whether environmental arsenic exposure increases risk of neural tube defects in humans is unknown. METHODS: We describe a new case-control study in Bangladesh, a country currently experiencing an epidemic of arsenic poisoning through contaminated drinking water. We plan to understand how arsenic influences risk of neural tube defects in humans through mechanisms that include disruption of maternal glucose and folate metabolism, as well as epigenetic effects...
November 1, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27785824/a-core-syllabus-for-the-teaching-of-embryology-and-teratology-to-medical-students
#13
Francis A Fakoya, Elpida Emmanouil-Nikoloussi, Deepak Sharma, Bernard J Moxham
Clinical relevance in the teaching of biomedical sciences within health care courses presupposes that there is internationally agreed core material within the curricula. However, with the exception of a syllabus for neuroanatomy and gross anatomy of the head and neck for medical students, core syllabuses within many of the specialized anatomical sciences have yet to be developed. The International Federation of Associations of Anatomists aims to formulate internationally accepted core syllabuses for all anatomical sciences disciplines initially using Delphi Panels that comprise anatomists, scientists, and clinicians who evaluate syllabus content...
October 27, 2016: Clinical Anatomy
https://www.readbyqxmd.com/read/27784201/iodine-supplementation-in-women-during-preconception-pregnancy-and-lactation-current-clinical-practice-by-u-s-obstetricians-and-midwives
#14
Simone De Leo, Elizabeth N Pearce, Lewis E Braverman
BACKGROUND: Iodine deficiency is a major public-health problem throughout the world, especially for pregnant women, and it is considered the most common cause of preventable intellectual impairment. In the United States, iodine status in pregnant women is considered mildly deficient. Therefore, the Endocrine Society, the American Thyroid Association, the Teratology Society, and the American Academy of Pediatrics recommend that women receive prenatal vitamins containing 150 μg of iodine daily during preconception, pregnancy, and lactation...
December 22, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27708197/influence-of-study-design-on-developmental-and-reproductive-toxicology-study-outcomes
#15
Paul M D Foster
Regulatory studies of developmental and reproductive toxicity (DART) studies have remained largely unchanged for decades, with exposures occurring at various phases of the reproductive cycle and toxicity evaluations at different ages/times depending on the study purpose. The National Toxicology Program has conducted studies examining the power to detect adverse effects where there is a prenatal exposure, but evaluations occur postnatally. In these studies, examination is required of only 1 male and female pup from each litter beyond weaning...
January 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/27663874/relationships-for-mercury-and-selenium-in-muscle-and-ova-of-gravid-freshwater-fish
#16
David B Donald
At high concentrations, mercury (Hg) is toxic to vertebrates, causing neurological, behavioral, and teratological dysfunction. Selenium (Se) not only is an essential element but also has a high affinity for Hg, binding to organic methyl mercury at a molar ratio of Se/Hg of 1:1. Ratios of <1 increase risk of Hg toxicity. For gravid fish, low concentrations of Se in ova could increase potential for Hg toxicity, compromising embryonic development and fitness of fry. Mercury and selenium concentrations and ratios were investigated in the muscle and ovaries of six species from five families of fish to assess potential for risk to ecological fitness...
October 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27634006/the-56th-annual-meeting-of-the-japanese-teratology-society-new-developments-and-future-perspectives-of-teratology-study-translational-study-to-link-teratology-to-nutrition-overview
#17
https://www.readbyqxmd.com/read/27630750/pregnancy-and-lactation-advice-how-does-australian-product-information-compare-with-established-information-resources
#18
Emma Brown, Elizabeth Hotham, Neil Hotham
BACKGROUND: Product information is a popular medicines information resource; however, there is some evidence that its pregnancy and lactation information is overconservative, which can lead to inadequate treatment of pregnant and lactating women. METHODS: A thorough analysis of pregnancy and lactation information within Australian Product Information and Consumer Medicines Information was performed. The statements within these resources were compared with established clinical resources: Australian Medicines Handbook, Therapeutic Guidelines, South Australian Perinatal Practice Guidelines, Organization of Teratology Information Specialists, LactMed, Motherisk and the Pregnancy and Breastfeeding Medicines Guide published by the Royal Women's Hospital Melbourne...
September 2016: Obstetric Medicine
https://www.readbyqxmd.com/read/27589342/consistency-of-maternal-telephone-administration-of-the-asthma-control-test-using-postpartum-recall-compared-to-repeated-measures-during-pregnancy
#19
Ronghui Xu, Mofei Li, Diana L Johnson, Yunjun Luo, Christina D Chambers
BACKGROUND: Suboptimal asthma control during pregnancy may impact perinatal outcomes. U.S. guidelines recommend questionnaires to assess asthma control including the Asthma Control Test (ACT). It is unknown in a research setting to what extent recall differs by the time between symptom occurrence and the administration of the questionnaire. METHODS: Between 2009 - 2014, 196 pregnant asthmatic women were recruited by the Organization of Teratology Information Specialists (OTIS) MotherToBaby Pregnancy Studies...
September 2, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27567698/prenatal-cannabis-exposure-the-first-hit-to-the-endocannabinoid-system
#20
REVIEW
Kimberlei A Richardson, Allison K Hester, Gabrielle L McLemore
As more states and countries legalize medical and/or adult recreational marijuana use, the incidences of prenatal cannabis exposure (PCE) will likely increase. While young people increasingly view marijuana as innocuous, marijuana preparations have been growing in potency in recent years, potentially creating global clinical, public health, and workforce concerns. Unlike fetal alcohol spectrum disorder, there is no phenotypic syndrome associated with PCE. There is also no preponderance of evidence that PCE causes lifelong cognitive, behavioral, or functional abnormalities, and/or susceptibility to subsequent addiction...
November 2016: Neurotoxicology and Teratology
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