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Teratology

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https://www.readbyqxmd.com/read/28439719/radiological-imaging-of-teratological-fetuses-what-can-we-learn
#1
REVIEW
Lucas L Boer, A N Schepens-Franke, J J A van Asten, D G H Bosboom, K Kamphuis-van Ulzen, T L Kozicz, D J Ruiter, R-J Oostra, W M Klein
OBJECTIVES: To determine the advantages of radiological imaging of a collection of full-term teratological fetuses in order to increase their scientific and educational value. BACKGROUND : Anatomical museums around the world exhibit full-term teratological fetuses. Unfortunately, these museums are regularly considered as "morbid cabinets". Detailed dysmorphological information concerning the exhibited specimens is often lacking. Moreover, fetuses with severe and complex congenital anomalies are frequently diagnosed incompletely, incorrectly or not at all...
April 24, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28422426/dinosaurs-chameleons-humans-and-evo-devo-path-linking-%C3%A3-tienne-geoffroy-s-teratology-waddington-s-homeorhesis-alberch-s-logic-of-monsters-and-goldschmidt-hopeful-monsters
#2
REVIEW
Rui Diogo, Geoffrey Guinard, Raul E Diaz
Since the rise of evo-devo (evolutionary developmental biology) in the 1980s, few authors have attempted to combine the increasing knowledge obtained from the study of model organisms and human medicine with data from comparative anatomy and evolutionary biology in order to investigate the links between development, pathology, and macroevolution. Fortunately, this situation is slowly changing, with a renewed interest in evolutionary developmental pathology (evo-devo-path) in the past decades, as evidenced by the idea to publish this special, and very timely, issue on "Developmental Evolution in Biomedical Research...
May 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28398706/can-we-rely-on-pharmacy-claims-databases-to-ascertain-maternal-use-of-medications-during-pregnancy
#3
Jin-Ping Zhao, Odile Sheehy, Jessica Gorgui, Anick Bérard
BACKGROUND: Administrative databases are increasingly used to measure drug exposure in perinatal pharmacoepidemiology. We aimed to estimate the concordance between records of prescriptions filled in pharmacies and self-reported drug use during pregnancy. METHODS: Data on self-reported medication use were collected at each trimester of pregnancy among a sub-sample from the Organization of Teratology Information Specialists Antidepressants in Pregnancy Cohort. Women were eligible if they were Quebec resident and provided their pharmacist's contact information...
April 3, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28398660/gestational-and-lactational-exposure-to-an-environmentally-relevant-mixture-of-brominated-flame-retardants-effects-on-neurodevelopment-and-metabolism
#4
Emily W Y Tung, Alice Kawata, Marc Rigden, Wayne J Bowers, Don Caldwell, Alison C Holloway, Bernard Robaire, Barbara F Hales, Michael G Wade
BACKGROUND: Developmental exposure to brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), has been associated with impaired neurodevelopment and some symptoms of metabolic syndrome. However, there are inconsistencies in studies reporting neurodevelopmental effects with studies of pure substances more likely to report effects than studies of technical products. In addition, the influence of early BFR exposures on later development of metabolic disease-like symptoms has not been investigated...
April 17, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28398022/teratology-of-valproic-acid-an-updated-review-of-the-possible-mediating-mechanisms
#5
Adalisa Ponzano, Gian M Tiboni
Valproic acid (VPA) is an anti-epileptic drug (AED) which is currently being investigated for its potential application in the treatment of several types of cancers, including solid and non-solid tumor. It is well known that prenatal exposure to VPA largely increases the risk for malformations and other developmental disorders. This review concentrates on clinical and experimental data on congenital anomalies attributed to maternal VPA exposure during. Particular emphasis is paid to the potential mechanisms underlying VPA-induced malformations...
April 10, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28347437/neural-mechanisms-of-functional-impairment-across-the-lifespan-the-15th-biennial-meeting-of-the-international-neurotoxicology-association-and-39th-annual-meeting-of-the-neurobehavioral-teratology-society
#6
EDITORIAL
Christoph van Thriel, Ed Levin, Pam Lein, Lucio G Costa, Remco H S Westerink
No abstract text is available yet for this article.
March 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28317256/thomas-h-shepard-m-d-pioneer-in-embryology-and-teratology
#7
Alan G Fantel, Janine E Polifka, Godfrey P Oakley
Dr. Thomas H. Shepard died on October 3, 2016 at the age of 93. He was a major figure in the fields of teratology, embryonic and fetal pathology, and pediatrics. He was beloved by his colleagues as he was by the many students and fellows whom he taught, mentored and befriended. His contributions to teratology are extraordinary and he is greatly missed. © 2017 Wiley Periodicals, Inc.
March 20, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28288352/effects-of-dechlorane-plus-exposure-on-axonal-growth-musculature-and-motor-behavior-in-embryo-larval-zebrafish
#8
Xiangping Chen, Qiaoxiang Dong, Yuanhong Chen, Zhenxuan Zhang, Changjiang Huang, Yaxian Zhu, Yong Zhang
Developmental neurobehavioral toxicity of Dechlorane Plus (DP) was investigated using the embryo-larval stages of zebrafish (Danio rerio). Normal fertilized embryos were waterborne exposed to DP at 15, 30, 60 μg/L beginning from 6 h post-fertilization (hpf). Larval teratology, motor activity, motoneuron axonal growth and muscle morphology were assessed at different developmental stages. Results showed that DP exposure significantly altered embryonic spontaneous movement, reduced touch-induced movement and free-swimming speed and decreased swimming speed of larvae in response to dark stimulation...
March 10, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28286266/diabetes-induced-effects-on-cardiomyocytes-in-chick-embryonic-heart-micromass-and-mouse-embryonic-d3-differentiated-stem-cells
#9
Omar J Mohammed, Muhammad Liaque Latif, Margaret K Pratten
Diabetes mellitus during pregnancy is a considerable medical challenge, since it is related to ‎augmented morbidity and mortality concerns for both the fetus ‎and the pregnant woman. Records show that the etiology of diabetic ‎embryopathy is complicated, as many teratological factors might be involved ‎in the mechanisms of diabetes mellitus-induced congenital malformation. ‎In this study, the potential cardiotoxic effect of hyperglycemia with hyperketonemia was investigated by using two in vitro models; primary chick embryonic cardiomyocytes and stem cell derived cardiomyocytes, where adverse effects were recorded in both systems...
March 9, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28267574/applying-evolutionary-genetics-to-developmental-toxicology-and-risk-assessment
#10
REVIEW
Maxwell C K Leung, Andrew C Procter, Jared V Goldstone, Jonathan Foox, Robert DeSalle, Carolyn J Mattingly, Mark E Siddall, Alicia R Timme-Laragy
Evolutionary thinking continues to challenge our views on health and disease. Yet, there is a communication gap between evolutionary biologists and toxicologists in recognizing the connections among developmental pathways, high-throughput screening, and birth defects in humans. To increase our capability in identifying potential developmental toxicants in humans, we propose to apply evolutionary genetics to improve the experimental design and data interpretation with various in vitro and whole-organism models...
March 4, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28118300/early-application-of-the-ponseti-casting-technique-for-clubfoot-correction-in-sick-infants-at-the-neonatal-intensive-care-unit
#11
Ehud Lebel, Eliraz Weinberg, Tamar M Berenstein-Weyel, Ruben Bromiker
The treatment of congenital clubfoot has been changing rapidly since the mid-1990s with the worldwide use of the Ponseti method for serial casting and limited operative interventions. This method was first applied for isolated clubfeet and later on for other types of clubfoot (teratologic, residual, and neurogenic). Premature babies sustaining clubfoot commonly suffer from additional congenital and acquired medical problems. These may postpone clubfoot management until urgent issues are resolved. The current study describes early initiation of treatment of clubfoot in premature babies at the neonatal intensive care unit (NICU) and their outcomes...
March 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28008752/high-levels-of-iron-supplementation-prevents-neural-tube-defects-in-the-fpn1-ffe-mouse-model
#12
Bethany A Stokes, Julia A Sabatino, Irene E Zohn
BACKGROUND: Periconception maternal nutrition and folate in particular are important factors influencing the incidence of neural tube defects (NTDs). Many but not all NTDs are prevented by folic acid supplementation and there is a pressing need for additional strategies to prevent these birth defects. Other micronutrients such as iron are potential candidates, yet a clear role for iron deficiency in contributing to NTDs is lacking. Our previous studies with the flatiron (ffe) mouse model of Ferroportin1 (Fpn1) deficiency suggest that iron is required for neural tube closure and forebrain development raising the possibility that iron supplementation could prevent NTDs...
January 30, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28007609/editorial-updates-in-teratology
#13
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
January 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27915015/who-seeks-teratology-information-service-s-advice-assessing-the-risk-of-selection-bias-in-observational-cohort-studies-on-drug-risks-in-pregnancy
#14
Evelin Beck, Anna Lechner, Christof Schaefer
All women of reproductive age should have access to Teratology Information Services (TIS). Observational cohort studies based on TIS data are one of the most important sources for risk characterization of drugs during pregnancy. A selection in TIS populations towards higher socioeconomic level would compromise the TIS' goal of health prevention and the quality of research. The aim of this study is to investigate in which respect Berlin TIS enquirers are different from the general female population of reproductive age in Germany...
November 30, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27891785/editorial-brain-malformation-surveillance-in-the-zika-era
#15
EDITORIAL
Edwin Trevathan
The current surveillance systems for congenital microcephaly are necessary to monitor the impact of Zika virus (ZIKV) on the developing human brain, as well as the ZIKV prevention efforts. However, these congenital microcephaly surveillance systems are insufficient. Abnormalities of neuronal differentiation, development and migration may occur among infants with normal head circumference who have intrauterine exposure to ZIKV. Therefore, surveillance for congenital microcephaly does not ascertain many of the infants seriously impacted by congenital ZIKV infection...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27891246/two-headed-mutants-of-the-lamprey-a-basal-vertebrate
#16
Daichi G Suzuki
BACKGROUND: This is the first report of two-headed (bicephaly) lamprey twins. Although lampreys sit at a crucial phylogenetic position, there are only a few reports on their teratology and developmental abnormalities. RESULTS: Two-headed mutants were obtained by artificial fertilization in the laboratory as spontaneous occurrences. All mutants were derived from single fertilizations using single male and female gametes, suggestive of a genetic background. The anterio-posterior position of the axonal bifurcation and symmetricity varied in each mutant...
2016: Zoological Letters
https://www.readbyqxmd.com/read/27884274/50-years-ago-in-the-journal-of-pediatrics-dysmorphology-teratology
#17
Jennifer A Accardo
No abstract text is available yet for this article.
December 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27883261/prevention-of-neural-tube-defects-in-lrp2-mutant-mouse-embryos-by-folic-acid-supplementation
#18
Julia A Sabatino, Bethany A Stokes, Irene E Zohn
BACKGROUND: Neural tube defects (NTDs) are among the most common structural birth defects in humans and are caused by the complex interaction of genetic and environmental factors. Periconceptional supplementation with folic acid can prevent NTDs in both mouse models and human populations. A better understanding of how genes and environmental factors interact is critical toward development of rational strategies to prevent NTDs. Low density lipoprotein-related protein 2 (Lrp2) is involved in endocytosis of the folic acid receptor among numerous other nutrients and ligands...
January 20, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/27876346/withdrawn-45th-annual-meeting-of-the-european-teratology-society
#19
(no author information available yet)
This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
July 14, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27851994/pregnancy-outcomes-after-maternal-varenicline-use-analysis-of-surveillance-data-collected-by-the-european-network-of-teratology-information-services
#20
J L Richardson, S Stephens, L M Yates, O Diav-Citrin, J Arnon, D Beghin, A Kayser, D Kennedy, D Cupitt, B Te Winkel, M Peltonen, Y C Kaplan, S H L Thomas
Varenicline is a smoking cessation aid for which limited data exist concerning safety during human pregnancy. This multicentre prospective observational comparative cohort study was undertaken using surveillance data collected by the European Network of Teratology Information Services. The study sample consisted of 89 varenicline exposed pregnancies and two matched comparator groups; 267 non-teratogen exposed (NTE) controls and 78 exposed to nicotine replacement therapy or bupropion (NRT/B) for smoking cessation...
November 13, 2016: Reproductive Toxicology
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