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Teratology

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https://www.readbyqxmd.com/read/29334310/dendritic-polyglycerol-nanoparticles-show-charge-dependent-bio-distribution-in-early-human-placental-explants-and-reduce-hcg-secretion
#1
Herbert Juch, Liudmila Nikitina, Sabine Reimann, Martin Gauster, Gottfried Dohr, Barbara Obermayer-Pietsch, Denise Hoch, Karin Kornmueller, Rainer Haag
A thorough understanding of nanoparticle bio-distribution at the feto-maternal interface will be a prerequisite for their diagnostic or therapeutic application in women of childbearing age and for teratologic risk assessment. Therefore, the tissue interaction of biocompatible dendritic polyglycerol nanoparticles (dPG-NPs) with first- trimester human placental explants were analyzed and compared to less sophisticated trophoblast-cell based models. First-trimester human placental explants, BeWo cells and primary trophoblast cells from human term placenta were exposed to fluorescence labeled, ∼5 nm dPG-NPs, with differently charged surfaces, at concentrations of 1 µM and 10 nM, for 6 and 24 h...
January 15, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29310562/programmatic-changes-to-reduce-mortality-and-morbidity-in-humanitarian-congenital-cardiac-surgery
#2
Tyler J Wallen, George J Arnaoutakis, Randa Blenden, Rodrigo Soto
BACKGROUND: This report documents the outcomes of cardiac surgical mission trips organized by the International Children's Heart Foundation (ICHF), a nongovernmental organization that provides congenital heart surgery services to the developing world, and discusses factors associated with a reduction of mortality and morbidity in this setting. METHODS: A retrospective review of a prospectively maintained database was conducted to identify any patient who underwent surgical intervention during the course of an ICHF mission trip...
January 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29287953/is-the-transverse-acetabular-ligament-hypertrophied-and-hindering-reduction-in-developmental-dysplasia-of-hip
#3
Soon Hyuck Lee, Woo Young Jang, Gi Won Choi, Young Keun Lee, Hae Woon Jung
PURPOSE: To investigate the arthroscopic pathoanatomy of the transverse acetabular ligament (TAL) and determine whether a TAL incision is necessary for the concentric reduction of developmental dysplasia of the hip (DDH) in infants and young children. METHODS: We retrospectively reviewed patients who underwent arthroscopic-assisted reduction for DDH between July 2008 and April 2016. The indications for this intervention included patients in whom closed reduction failed and those who did not require bone operations...
December 26, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29276976/behavioural-phenotypes-in-mice-after-prenatal-and-early-postnatal-exposure-to-intermediate-frequency-magnetic-fields
#4
Kajal Kumari, Hennariikka Koivisto, Capstick Myles, Naarala Jonne, Viluksela Matti, Tanila Heikki, Juutilainen Jukka
Electromagnetic fields are ubiquitous in the environment. Human exposure to intermediate frequency (IF) fields is increasing due to applications like electronic article surveillance systems, wireless power transfer, and induction heating cooking hobs. However, there are limited data on possible health effects of exposure to IF magnetic fields (MF). In the present study, we set out to assess cognitive and behavioural effects of IF MF in mice exposed during prenatal and early postnatal periods. Pregnant female mice were exposed continuously to 7...
December 22, 2017: Environmental Research
https://www.readbyqxmd.com/read/29242185/will-the-antarctic-tardigrade-acutuncus-antarcticus-be-able-to-withstand-environmental-stresses-due-to-global-climate-change
#5
Ilaria Giovannini, Tiziana Altiero, Roberto Guidetti, Lorena Rebecchi
Since conditions in Continental Antarctica are highly selective and extremely hostile to life, its biota is depauperate, but well adapted to live in this region. Global climate change has the potential to impact Continental Antarctica organisms because of increasing temperatures and ultraviolet radiation. This research evaluates how ongoing climate changes will affect Antarctic species, and if Antarctic organisms will be able to adapt to the new environmental conditions. Tardigrades represent the main terrestrial components of Antarctic meiofauna; therefore the pan-Antarctic tardigrade Acutuncus antarcticus was used as model to predict the fate of Antarctic meiofauna threatened by climate changes...
December 14, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29223040/the-ascidian-embryo-teratogenicity-assay-in-ciona-intestinalis-as-a-new-teratological-screening-to-test-the-mixture-effect-of-the-co-exposure-to-ethanol-and-fluconazole
#6
Maria Battistoni, Silvia Mercurio, Gentile Francesco Ficetola, Francesca Cristiana Metruccio, Elena Menegola, Roberta Pennati
The aim of this work was to evaluate the Ascidian Embryo Teratogenicity assay (AET) as new alternative invertebrate model to test the developmental effects of the co-exposure to ethanol and fluconazole. Ciona intestinalis embryos were exposed to the azolic fungicide fluconazole, (FLUCO, 7.8-250μM), to ethanol (Eth, 0.01-0.5%) and to their mixture (0.01% Eth+FLUCO 7.8-250μM) from neurula to larval stage. At the end of the exposure period, larvae were morphologically evaluated and benchmark analysis performed by using the PROAST modelling software...
December 2, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29216900/treatment-with-a-dna-methyltransferase-inhibitor-feminizes-zebrafish-and-induces-long-term-expression-changes-in-the-gonads
#7
Laia Ribas, Konstantinos Vanezis, Marco Antonio Imués, Francesc Piferrer
BACKGROUND: The role of epigenetic modifications such as DNA methylation during vertebrate sexual development is far from being clear. Using the zebrafish model, we tested the effects of one of the most common DNA methyltransferase (dnmt) inhibitor, 5-aza-2'-deoxycytidine (5-aza-dC), which is approved for the treatment of acute myeloid leukaemia and is under active investigation for the treatment of solid tumours. Several dose-response experiments were carried out during two periods, including not only the very first days of development (0-6 days post-fertilization, dpf), as done in previous studies, but also, and as a novelty, the period of gonadal development (10-30 dpf)...
December 8, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29215149/pregnancy-outcomes-in-women-on-metformin-for-diabetes-or-other-indications-among-those-seeking-teratology-information-services
#8
Alice Panchaud, Valentin Rousson, Thierry Vial, Nathalie Bernard, David Baud, Emmanuelle Amar, Marco De Santis, Alessandra Pistelli, Anne Dautriche, Frederique Beau-Salinas, Matteo Cassina, Hannah Dunstan, Anneke Passier, Yusuf Cem Kaplan, Mine Kadioglu Duman, Eva Maňáková, Georgios Eleftheriou, Gil Klinger, Ursula Winterfeld, Laura E Rothuizen, Thierry Buclin, Chantal Csajka, Sonia Hernandez-Diaz
BACKGROUND: Metformin is used to treat type 2 diabetes, polycystic ovary syndrome associated infertility, and gestational diabetes. Human studies evaluating the safety of metformin in early pregnancy are scarce. METHOD: We evaluated the risk of major birth defects and pregnancy losses in a cohort of pregnant women exposed to metformin during first trimester for different indications relative to a matched unexposed reference group. RESULTS: The risk of major birth defects was 5...
December 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29156433/evaluating-features-of-periphytic-diatom-communities-as-biomonitoring-tools-in-fresh-brackish-and-marine-waters
#9
Lalit K Pandey, Yogesh Chandra Sharma, Jihae Park, Soyeon Choi, Hojun Lee, Jie Lyu, Taejun Han
The aims of this study were to assess the biodiversity of periphytic diatom assemblages in fresh, brackish and marine waterbodies of Korea, and to assess the effect of environmental and anthropogenic factors on parameters such as the quantity and biovolume of lipid bodies and deformations of diatoms as early warning measures of anthropogenic impact. Diatom samples were collected from 31 sites (14 freshwater, 10 brackish and 7 marine), which included less impacted (upstream) and impacted (downstream) sites in each water type...
November 10, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29105191/57th-annual-meeting-of-the-japanese-teratology-society-seeking-a-contact-between-humans-and-experimental-animals
#10
Hiroaki Aoyama
No abstract text is available yet for this article.
November 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/29063150/drug-safety-in-pregnancy-the-german-embryotox-institute
#11
Katarina Dathe, Christof Schaefer
Since 1988, the German Embryotox institute combines individual counselling of pregnant women and their health care providers (HCP) with research on drug safety in pregnancy. In addition, Embryotox offers web-based information which covers the most important and most frequently requested pharmaceutical substances. In contrast to ready-made drug risk information in package leaflets and other product information, individual counselling considers different clinical settings such as (1) looking for a drug of choice or planning pregnancy under medication, (2) risk assessment of a particular drug that has already been taken during an (unplanned) pregnancy and (3) evaluation of an adverse pregnancy outcome in association with a particular medication...
October 24, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29038967/morphology-and-the-central-nervous-system-of-eratigena-atrica-affected-by-a-complex-anomaly-in-the-anterior-part-of-the-prosoma
#12
Teresa Napiórkowska, Julita Templin, Katarzyna Wołczuk
Spider embryogenesis is affected by a range of environmental factors. Any sudden, drastic change in the environment may impair spider development, leading to various body deformities. In the present study, we analyze changes in the morphology and structure of the central nervous system of an Eratigena atrica larva, obtained in a teratological experiment in which embryos were exposed to alternating temperatures of 14 and 32 °C for the first 10 days. The studied larva had three pedipalps on the right side of the prosoma (polymely), two of which were fused along their entire length (total heterosymely)...
October 17, 2017: Invertebrate Neuroscience: IN
https://www.readbyqxmd.com/read/28957901/closed-reduction-of-congenital-dislocation-of-the-hip-prediction-factors-and-results
#13
Michal S Galek-Aldridge, Jan Jaap de Graeff, Peter A A Struijs
From 2009 to 2015, 15 infants with a congenital dislocation of the hip were treated with closed reduction under anaesthesia, after first being treated with Pavlik bandaging. A retrospective study was carried out with a minimum follow-up of 1 year to assess the success rate of the procedure and predictive factors. Twelve out of 15 (80%) patients achieved successful reduction. In the successful cases, the Barlow test was positive and the safe zone was 20° or more. In the unsuccessful cases, there was a negative Barlow present in the outpatient clinic and the safe zone was less than 20°...
September 27, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28948136/fetal-alcohol-spectrum-disorders-a-case-study
#14
Leila Glass, Sarah N Mattson
This grand rounds manuscript reviews important considerations in developing case conceptualizations for individuals with a history of prenatal alcohol exposure. This case study provides an introduction to fetal alcohol spectrum disorders, diagnostic issues, a detailed description of the individual's history, presenting symptoms, neuropsychological test results, and an integrated summary. We describe a 9-year old girl diagnosed with a fetal alcohol spectrum disorder (FASD): Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE)...
June 2017: Journal of Pediatric Neuropsychology
https://www.readbyqxmd.com/read/28934925/editorial-teratology-and-reproductive-toxicology-of-anticancer-agents
#15
EDITORIAL
Gian Mario Tiboni
No abstract text is available yet for this article.
2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28769788/association-between-cyp2d6-genotypes-and-the-risk-of-antidepressant-discontinuation-dosage-modification-and-the-occurrence-of-maternal-depression-during-pregnancy
#16
Anick Bérard, Andrea Gaedigk, Odile Sheehy, Christina Chambers, Mark Roth, Pina Bozzo, Diana Johnson, Kelly Kao, Sharon Lavigne, Lori Wolfe, Dee Quinn, Kristen Dieter, Jin-Ping Zhao
Importance: Polymorphic expression of drug metabolizing enzymes affects the metabolism of antidepressants, and thus can contribute to drug response and/or adverse events. Pregnancy itself can affect CYP2D6 activity with profound variations determined by CYP2D6 genotype. Objective: To investigate the association between CYP2D6 genotype and the risk of antidepressant discontinuation, dosage modification, and the occurrence of maternal CYP2D6, Antidepressants, Depression during pregnancy. Setting: Data from the Organization of Teratology Information Specialists (OTIS) Antidepressants in Pregnancy Cohort, 2006-2010, were used...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28769610/the-species-of-haplothrips-thysanoptera-phlaeothripinae-and-related-genera-recorded-from-the-hawaiian-islands
#17
Laurence A Mound, Janis N Matsunaga
An illustrated identification key is provided to 17 species of Thysanoptera: Phlaeothripinae from Hawaii that are members of the Tribe Haplothripini, together with a further species that is similar in general appearance to members of that Tribe. Of these 18 species, 13 are considered introduced from other parts of the world, but five appear to be endemics. Known only from Hawaii, Haplothrips fissussyn. n. is considered to have been based on a teratological specimen and is placed as a synonym of the Hawaiian endemic Haplothrips davisi...
2017: ZooKeys
https://www.readbyqxmd.com/read/28765997/changes-in-femoral-head-size-and-growth-rate-in-young-children-with-severe-developmental-dysplasia-of-the-hip
#18
Matthew R Wanner, Randall T Loder, S Gregory Jennings, Fangqian Ouyang, Boaz Karmazyn
BACKGROUND: Developmental dysplasia of the hip (DDH) is known to result in smaller femoral head size in toddlers; however, alterations in femoral head size and growth have not been documented in infants. OBJECTIVE: To determine with ultrasound (US) whether femoral head size and growth are altered in infants (younger than 1 year of age) with severe DDH. MATERIALS AND METHODS: We identified all patients at our tertiary care children's hospital from 2002 to 2014 who underwent US for DDH...
December 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28757310/recommendations-for-harmonization-of-data-collection-and-analysis-of-developmental-neurotoxicity-endpoints-in-regulatory-guideline-studies-proceedings-of-workshops-presented-at-society-of-toxicology-and-joint-teratology-society-and-neurobehavioral-teratology
#19
REVIEW
Abby A Li, Larry P Sheets, Kathleen Raffaele, Virginia Moser, Angela Hofstra, Alan Hoberman, Susan L Makris, Robert Garman, Brad Bolon, Wolfgang Kaufmann, Roland Auer, Edmund Lau, Thomas Vidmar, Wayne J Bowers
The potential for developmental neurotoxicity (DNT) of environmental chemicals may be evaluated using specific test guidelines from the US Environmental Protection Agency or the Organisation for Economic Cooperation and Development (OECD). These guidelines generate neurobehavioral, neuropathological, and morphometric data that are evaluated by regulatory agencies globally. Data from these DNT guideline studies, or the more recent OECD extended one-generation reproductive toxicity guideline, play a pivotal role in children's health risk assessment in different world areas...
July 27, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28739212/conference-programme-45th-annual-conference-of-the-european-teratology
#20
(no author information available yet)
No abstract text is available yet for this article.
July 21, 2017: Reproductive Toxicology
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