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https://www.readbyqxmd.com/read/29753929/best-practices-for-developmental-toxicity-assessment-for-classification-and-labeling
#1
George Daston, Aldert Piersma, Leonello Attias, Manon Beekhuijzen, Connie Chen, Jennifer Foreman, Nina Hallmark, Isabelle Leconte
Many chemicals are going through a hazard-based classification and labeling process in Europe. Because of the significant public health implications, the best science must be applied in assessing developmental toxicity data. The European Teratology Society and Health and Environmental Sciences Institute co-organized a workshop to consider best practices, including data quality and consistency, interpretation of developmental effects in the presence of maternal toxicity, human relevance of animal data, and limits of chemical classes...
May 10, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29725877/dose-dependent-teratology-in-humans-clinical-implications-for-prevention
#2
REVIEW
Gideon Koren, Matitiahu Berkovitch, Asher Ornoy
Since the inception of clinical teratology, the vast majority of scientific work has focused on identification of drugs and environmental agents causing malformations in humans as a dichotomous variable (i.e. yes or no), as well as the relative and absolute risks of such occurrences. Generally, the dose dependency of such events has not been investigated. With the establishment of large pregnancy databases, dose-dependence relationships are being uncovered for increasing numbers of medications, including valproic acid, carbamazepine, phenobarbital, lamotrigine, topiramate, and lithium...
May 4, 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29704628/42nd-annual-meeting-of-the-developmental-neurotoxicology-society-held-in-conjunction-with-the-58th-annual-meeting-of-the-teratology-society-hilton-clearwater-beach-resort-clearwater-beach-fl-june-23-27-2018
#3
https://www.readbyqxmd.com/read/29663712/study-of-normal-and-abnormal-prenatal-development-using-the-kyoto-collection-of-human-embryos
#4
Kohei Shiota
Four topics on normal and abnormal human prenatal development are briefly reviewed. These studies were made possible by using the Kyoto Collection of Human Embryos, the largest collection of human embryo specimens procured after therapeutic abortion. The topics discussed include: (1) variability of human embryo development and implications for clinical teratology, (2) abnormal development in human embryos and intrauterine fate of human conceptuses, (3) holoprosencephaly, and (4) maternal hyperthermia in early pregnancy and birth defects...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29660063/five-successful-pregnancies-with-antenatal-anakinra-exposure
#5
Chelsey J F Smith, Christina D Chambers
Objectives: Our aim is to add to the limited existing prospective data on IL-1 inhibitor use in pregnancy. Methods: Data were obtained from the Organization of Teratology Information Specialists Autoimmune Disease in Pregnancy Project, a prospective cohort study of pregnancy outcomes in the USA and Canada. Eligible women were enrolled prior to 19 weeks' gestation between 2004 and 2017. Outcomes were obtained by maternal interview and medical record abstraction. Results: Five pregnancies with anakinra exposure were identified, all resulting in full-term singleton live births with no major or long-term complications...
April 12, 2018: Rheumatology
https://www.readbyqxmd.com/read/29616743/the-chick-limb-embryology-genetics-and-teratology
#6
Megan G Davey, Matthew Towers, Neil Vargesson, Cheryll Tickle
The chick embryo has a long history in investigations of vertebrate limb development because of the ease with which its limbs can be experimentally manipulated. Early studies elucidated the fundamental embryology of the limb and identified the key signalling regions that govern its development. The chick limb became a leading model for exploring the concept of positional information and understanding how patterns of differentiated cells and tissues develop in vertebrate embryos. When developmentally important molecules began to be identified, experiments in chick limbs were crucial for bridging embryology and molecular biology...
2018: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/29574361/diatom-responses-to-sewage-inputs-and-hydrological-alteration-in-mediterranean-streams
#7
Elisabet Tornés, Jordi-René Mor, Ladislav Mandaric, Sergi Sabater
We analyzed the conjoint effects of sewage inputs and hydrological alteration on the occurrence of teratological forms and on the assemblage composition of stream benthic diatoms. The study was performed in 11 Mediterranean streams which received treated or untreated urban sewage (Impact sites, I), whose composition and morphological anomalies were compared to upstream unaffected (Control, C) sites. The impact sites had high concentrations of ammonium, phosphorus, and pharmaceutical compounds (antibiotics, analgesics, and anti-inflammatories), particularly in those receiving untreated sewage...
March 22, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29571046/the-contributions-of-dr-kathleen-k-sulik-to-fetal-alcohol-spectrum-disorders-research-and-prevention
#8
REVIEW
Scott E Parnell, Edward P Riley, Kenneth R Warren, Kathleen T Mitchell, Michael E Charness
Dr. Kathleen Sulik (Kathy) has spent 35 years studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASD). Beginning with her landmark 1981 Science paper describing the early gestational window when alcohol can cause the craniofacial malformations characteristic of FAS, Kathy has contributed a vast amount of research furthering our knowledge of FASD. After her seminal work that definitively demonstrated that alcohol is the causative factor in FAS, she and her lab went on to explore and define the stage-dependent effects of early gestational alcohol exposure on the face and brain in numerous different ways throughout her career...
June 2018: Alcohol
https://www.readbyqxmd.com/read/29550584/proceedings-of-the-2017-annual-meeting-of-the-fetal-alcohol-spectrum-disorders-study-group
#9
REVIEW
Jeffrey R Wozniak, Anna Y Klintsova, Derek A Hamilton, Sandra M Mooney
The 2017 Fetal Alcohol Spectrum Disorders Study Group (FASDSG) meeting was titled "Prenatal alcohol exposure in the context of multiple factors affecting brain development." The theme was reflected in the interactions between members of the Teratology Society and the FASDSG this year. The first keynote speaker, Elaine Faustman, Ph.D., was a liaison between the societies and spoke about systems biology and the multiple genetic and environmental influences on development. The second keynote speaker, Rebecca Knickmeyer, Ph...
June 2018: Alcohol
https://www.readbyqxmd.com/read/29525551/a-nine-legged-tick-report-of-a-morphological-anomaly-in-the-blacklegged-tick-ixodes-scapularis-acari-ixodidae-from-the-northeastern-united-states
#10
Goudarz Molaei, Eliza A H Little
Morphological anomalies have been reported in the blacklegged tick, Ixodes scapularis (Acari: Ixodidae), from the northeastern and upper Midwestern United States, complicating identification of this important vector of human pathogens. Here, we report a case of a local morphological anomaly in I. scapularis, parasitizing a human living in Connecticut. We used a dichotomous morphological key, high-resolution and scanning electron microscopy images, as well as DNA sequencing for identification. The specimen was identified as an adult female I...
March 5, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29512128/use-of-human-embryoid-bodies-for-teratology
#11
Anthony Flamier, Supriya Singh, Theodore P Rasmussen
Human birth defects are relatively common and can be caused by exposure to environmental teratogens or to pharmaceuticals with teratogenic activities. Human embryonic stem cells (hESCs), by virtue of their pluripotent nature, provide an excellent cellular platform for teratogen detection and risk assessment. This unit describes detailed protocols for the preparation and validation of highly pluripotent hESCs, the production of large quantities of aggregated multicellular spheroids composed of hESCs, and these spheroids' differentiation into embryoid bodies (EBs)...
February 21, 2018: Current Protocols in Toxicology
https://www.readbyqxmd.com/read/29488162/vincenzo-malacarne-1744-1816-and-the-first-description-of-the-human-cerebellum
#12
Alberto Zanatta, Céline Cherici, Alessandro Bargoni, Serena Buzzi, Valentina Cani, Paolo Mazzarello, Fabio Zampieri
Vincenzo Malacarne, professor of medicine, surgery, and obstetrics in Turin, Pavia, and Padua, Italy, represented a perfect example of an eighteenth century "letterato", combining interests in humanities, sciences, and politics, embodying the ideal of an encyclopedic and universal culture. He made important contributions in anatomy and surgery, teratology, obstetrics, neurology, and history of medicine, adopting a interdisciplinary approach based on the correlation between anatomy, surgery, and clinics...
February 27, 2018: Cerebellum
https://www.readbyqxmd.com/read/29452148/complete-inhibition-of-fetal-movement-in-the-day-40-pregnant-goat-model-by-the-piperidine-alkaloid-anabasine-but-not-related-alkaloids
#13
B T Green, S T Lee, J W Keele, K D Welch, D Cook, J A Pfister, W R Kem
Four chemically similar alkaloids, anabasine, anabaseine, epibatidine and dimethylphenylpiperazinium (DMPP), are potent nicotinic acetylcholine receptor agonists of fetal muscle nicotinic acetylcholine receptors in human TE-671 cells. Based on results with these cells, we hypothesized that the alkaloids would completely inhibit ultrasound-monitored fetal movement in a goat model. Different, single doses of anabasine, anabaseine, epibatidine, DMPP, or saline control were administered I.V. to pregnant goats on day 40 of gestation and the number of fetal movements per 5 min sample was measured by ultrasound at times 0, 0...
March 15, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29442908/systemic-toxicity-and-teratogenicity-of-copper-oxide-nanoparticles-and-copper-sulfate
#14
Ambika Vishnu Kadammattil, Shyama Prasad Sajankila, Suma Prabhu, Bhuvanagiri Nageshwar Rao, Bola Sadashiva Satish Rao
Acceleration in development of metallic nanoparticles for their utility in medical and technological applications due to their unique physicochemical properties has concurrently raised a matter of concern due to their potential toxicity. Of the enormous metallic nanostructures, copper oxide nanoparticles (CuONPs) having optical and electrochemical properties are scrutinized for theranostic applications. Therefore, their safety profile is of a major concern in optimizing a safe dose for its clinical utility...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442443/teratology-society-strategic-plan-2017-2022
#15
EDITORIAL
Alan M Hoberman
No abstract text is available yet for this article.
February 15, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29399953/history-and-highlights-of-the-teratological-collection-in-the-museum-anatomicum-of-leiden-university-the-netherlands
#16
Lucas L Boer, Peter L J Boek, Andries J van Dam, Roelof-Jan Oostra
The anatomical collection of the Anatomical Museum of Leiden University Medical Center (historically referred to as Museum Anatomicum Academiae Lugduno-Batavae) houses and maintains more than 13,000 unique anatomical, pathological and zoological specimens, and include the oldest teratological specimens of The Netherlands. Throughout four centuries hundreds of teratological specimens were acquired by more than a dozen collectors. Due to the rich history of this vast collection, teratological specimens can be investigated in a unique retrospective sight going back almost four centuries...
March 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29381232/categorization-of-fetal-external-findings-in-developmental-toxicology-studies-by-the-terminology-committee-of-the-japanese-teratology-society
#17
Yuko Izumi, Yojiro Ooshima, Kazuhiro Chihara, Michio Fujiwara, Yoshihiro Katsumata, Kohei Shiota
Categorization of fetal external findings in common laboratory animals, intended to make the agreement at Berlin Workshop in 2014 more practical, was proposed by the Terminology Committee of the Japanese Teratology Society at the Workshop in the 55th Japanese Teratology Society Annual Meeting in 2015. In the Workshop, 73 external findings, which had been categorized as "Gray zone" anomalies but not as "Malformation" or "Variation" in the 2014 Berlin Workshop, were discussed and classified as Malformation, "Non-structural abnormality," Variation, and "Not applicable...
January 30, 2018: Congenital Anomalies
https://www.readbyqxmd.com/read/29378258/pregnancy-outcomes-after-maternal-use-of-thiocolchicoside-a-case-series
#18
Yusuf C Kaplan, Elif Keskin-Arslan, Gözde Küçüksolak, Fatih Akyol, Barış Karadas, Sacit Nuri Görgel, Tijen Kaya-Temiz
OBJECTIVE: The 2014 report by European Medicines Agency (EMA) restricted the use of thiocolchicoside for all reproductive-age women. In this study, we aim to expand the systematically-collected human data and discuss it within the frame provided by this report. METHODS: We identified and evaluated the outcomes of 48 prospectively recorded pregnancies referred to Terafar (Teratology Information Service, Izmir, Turkey). RESULTS: Of 42 pregnancies with first-trimester exposure and known outcomes, 31 resulted in live births, four in miscarriage and seven ended with elective terminations...
March 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29367544/establishing-the-embryonic-axes-prime-time-for-teratogenic-insults
#19
REVIEW
Thomas W Sadler
A long standing axiom in the field of teratology states that the teratogenic period, when most birth defects are produced, occurs during the third to eighth weeks of development post-fertilization. Any insults prior to this time are thought to result in a slowing of embryonic growth from which the conceptus recovers or death of the embryo followed by spontaneous abortion. However, new insights into embryonic development during the first two weeks, including formation of the anterior-posterior, dorsal-ventral, and left-right axes, suggests that signaling pathways regulating these processes are prime targets for genetic and toxic insults...
September 11, 2017: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29341431/risk-of-infantile-hemangiomas-in-the-offspring-of-women-with-autoimmune-disease-and-the-pathogenic-implications-of-these-lesions
#20
Chelsey J F Smith, Kenneth L Jones, Diana L Johnson, Gretchen Bandoli, Loan K Robinson, Arthur Kavanaugh, Christina D Chambers
The purpose of this study was to analyze the risk of maternal autoimmune disease or associated treatments on infantile hemangiomas (IHs), a common benign vascular tumor in infants, and to better understand how maternal chronic inflammation may play a factor in the pathogenesis of these lesions. Eligible women from the United States and Canada who enrolled before 19 weeks' gestation and delivered at least one live born infant were recruited as part of the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease in Pregnancy Project from 2004-2013...
January 17, 2018: American Journal of Medical Genetics. Part A
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