Irina Demina, Ekaterina Mikhailova, Elena Zerkalenkova, Alexandra Semchenkova, Julia Roumiantseva, Alexandra Borkovskaya, Evgeny Matveev, Dmitry Abramov, Dmitry Konovalov, Natalia Miakova, Natalia Ponomareva, Julia Belkina, Konstantin Kondratchik, Yulia Olshanskaya, Galina Novichkova, Alexander Karachunskiy, Alexander Popov
OBJECTIVES: Mixed-phenotype acute leukemia (MPAL) is a rare disease associated with difficulties in the correct lineage assignment of leukemic cells. One of the least common subtypes within this category is characterized by the simultaneous presence of B- and T-lineage-defining antigens. Each case of suspected B/T MPAL should be considered in light of all available laboratory and clinical data to avoid misdiagnosis. METHODS: In this study, we describe 6 pediatric patients who presented with leukemic blasts bearing B- and T-lineage antigens at diagnosis, including their clinical, immunophenotypic, morphologic, and cytogenetic characteristics...
March 21, 2024: American Journal of Clinical Pathology