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https://www.readbyqxmd.com/read/28102052/increasing-incidence-of-invasive-and-in-situ-cervical-adenocarcinoma-in-the-netherlands-during-2004-2013
#1
Judith van der Horst, Albert G Siebers, Johan Bulten, Leon F Massuger, Inge McM de Kok
In the developed world, the incidence of cervical squamous cell carcinoma has decreased, however, the incidence of adenocarcinoma in situ (AIS) and invasive adenocarcinoma increased, predominantly in young females. The goal of this study was to evaluate the most recent incidence rates of AIS, adenocarcinoma, and squamous cell carcinoma of the uterine cervix in the Netherlands in 2004-2013. By using Dutch national pathology and cancer registries, we calculated European standardized incidence rates (ESR) and estimated annual percentage changes (EAPC) for AIS during 2004-2013 and for invasive cervical carcinomas during 1989-2013...
January 19, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28047139/we-de-201-02-a-statistical-analysis-tool-for-plan-quality-verification-in-hdr-brachytherapy-forward-planning-for-cervix-cancer
#2
R Ma, X Zhu, S Li, D Zheng, Y Lei, S Wang, V Verma, N Bennion, A Wahl, S Zhou
PURPOSE: High Dose Rate (HDR) brachytherapy forward planning is principally an iterative process; hence, plan quality is affected by planners' experiences and limited planning time. Thus, this may lead to sporadic errors and inconsistencies in planning. A statistical tool based on previous approved clinical treatment plans would help to maintain the consistency of planning quality and improve the efficiency of second checking. METHODS: An independent dose calculation tool was developed from commercial software...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044941/design-synthesis-and-biological-evaluation-of-a-phenyl-butyric-acid-derivative-n-4-chlorophenyl-4-phenylbutanamide-a-hdac6-inhibitor-with-anti-proliferative-activity-on-cervix-cancer-and-leukemia-cells
#3
Rodríguez-Fonseca Rolando Alberto, Sixto-López Yudibeth, Fragoso-Vázquez M Jonathan, Flores-Mejía Raúl, Cabrera-Pérez Laura Cristina, Vázquez-Moctezuma Ismael, Rosales-Hernández Martha Cecilia, Bello Martiniano, M Martínez-Archundia, Trujillo-Ferrara José Guadalupe, Becerra-Martínez Elvia, Correa-Basurto José
The epigenetic regulation of genes in cancer could be targeted by inhibiting Histone deacetylase 6 (HDAC6), an enzyme involved in several types of cancer such as lymphoma, leukemia, ovarian cancer, etc. Through in silico methods, a set of Phenyl butyric acid derivatives with possible HDAC6 inhibitory activity were designed, rendering monophenylamides and biphenylamides using tubacin (HDAC6 selective inhibitor) as reference. The target compounds were submitted to theoretical ADMET analyses and their binding properties on different HDAC6 conformers were evaluated through docking calculations...
January 2, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27984378/analysis-of-conservative-surgical-treatment-and-prognosis-of-microinvasive-squamous-cell-carcinoma-of-the-cervix-stage-ia1-results-of-follow-up-to-20-years
#4
Caio Augusto Hartman, Julio Cesar Teixeira, Sergio Bruno Barbosa, Stephanye Mariano Figueiredo, Liliana Aparecida Lucci De Angelo Andrade, Joana Froes Bragança Bastos
OBJECTIVE: The aim of this study was to evaluate the prognosis and recurrence of microinvasive squamous cervical (MIC) cancer stage IA1 in women treated conservatively or by hysterectomy, and followed-up to 20 years. METHODS: It was studied in a cohort of 139 women with MIC, 41 definitively managed by conization and 98 by hysterectomy from January 1994 to December 2003 and followed-up until 2013. The definitive treatment, age, conization technique (loop electrosurgical excision procedure or cold knife conization), cone margin, residual disease in hysterectomy specimen, and the association with recurrence (intraepithelial cervical neoplasia grade 3/intraepithelial vaginal neoplasia grade 3 or worse, and microinvasive or worse) were analyzed...
December 15, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27976366/proteomic-signatures-reveal-a-dualistic-and-clinically-relevant-classification-of-anal-canal-carcinoma
#5
Michael Herfs, Rémi Longuespée, Charles M Quick, Patrick Roncarati, Meggy Suarez-Carmona, Pascale Hubert, Alizée Lebeau, Diane Bruyere, Gabriel Mazzucchelli, Nicolas Smargiasso, Dominique Baiwir, Keith Lai, Andrew Dunn, Fabiola Obregon, Eric J Yang, Edwin De Pauw, Christopher P Crum, Philippe Delvenne
Etiologically linked to HPV infection, malignancies of the anal canal have substantially increased in incidence over the last 20 years. Although most anal squamous cell carcinomas (SCC) respond well to chemoradiotherapy, about 30% of patients experience a poor outcome, for undetermined reasons. Despite cumulative efforts for discovering independent predictors of overall survival, both nodal status and tumour size are still the only reliable factors predicting patient outcome. Recent efforts have revealed that the biology of HPV-related lesions in the cervix is strongly linked to the originally infected cell population...
December 15, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27939984/risk-of-cervical-intra-epithelial-neoplasia-and-invasive-cancer-of-the-cervix-in-des-daughters
#6
J Verloop, F E van Leeuwen, Th J M Helmerhorst, I M C M de Kok, E J M van Erp, H H van Boven, M A Rookus
OBJECTIVE: Women exposed to diethylstilbestrol in utero (DES) have an increased risk of clear cell adenocarcinoma (CCA) of the vagina and cervix, while their risk of non-CCA invasive cervical cancer is still unclear. METHODS: We studied the risk of pre-cancerous (CIN) lesions and non-CCA invasive cervical cancer in a prospective cohort of 12,182 women with self-reported DES exposure followed from 2000 till 2008. We took screening behavior carefully into account...
December 7, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27870295/infections-with-multiple-high-risk-hpv-types-are-associated-with-high-grade-and-persistent-low-grade-intraepithelial-lesions-of-the-cervix
#7
Louise De Brot, Bruno Pellegrini, Sabrina Teixeira Moretti, Dirce Maria Carraro, Fernando Augusto Soares, Rafael Malagoli Rocha, Glauco Baiocchi, Isabela Werneck da Cunha, Victor Piana de Andrade
BACKGROUND: Infections with multiple human papillomavirus (HPV) types (mHPV) in Papanicolaou tests have been reported but the histologic correlation and clinical meaning remains debatable. METHODS: The authors prospectively tested 37 HPV types using the Linear Array HPV Genotyping Test and correlated the results to cytology and histology findings in 260 women evaluated from June 2009 to October 2011 and followed for up to 60 months. RESULTS: HPV was detected in 148 of 235 samples (63%) and high-risk HPV was detected in 132 samples (56%)...
November 21, 2016: Cancer
https://www.readbyqxmd.com/read/27867048/feasibiility-and-learning-curve-of-robotic-laparo-endoscopic-single-site-surgery-in-gynecology
#8
Alexandre Buckley de Meritens, Julia Kim, Helen Dinkelspiel, Eloise Chapman-Davis, Thomas Caputo, Kevin Holcomb
Single-site laparoscopy has proven to be a desirable option for patients undergoing gynecologic surgery with some studies indicating improved cosmesis and less perioperative pain compared to standard approaches. This study describes the safety and feasibility of a novel robotic laparo-endoscopic single-site surgery (R-LESS) platform as it is incorporated into a surgeon's practice with extensive multiport robotic surgical experience but limited laparo-endoscopic single-site experience. We reviewed 83 women undergoing R-LESS by a single surgeon from September 2013 through August 2015...
November 17, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27815812/sentinel-node-mapping-in-endometrial-cancer-patients-comparing-spect-ct-gamma-probe-and-dye
#9
Federica Elisei, Cinzia Crivellaro, Daniela Giuliani, Carlotta Dolci, Elena De Ponti, Luca Montanelli, Maria La Manna, Luca Guerra, Maurizio Arosio, Claudio Landoni, Alessandro Buda
OBJECTIVE: The aim of this study was to compare preoperative SPECT/CT with gamma-probe and methylene blue-dye (MBD) in the identification of sentinel lymph node (SLN) in early stage endometrial cancer. METHODS: 40 stage-I EC patients (66.7 ± 9.7 years) underwent preoperative lymphoscintigraphy. After about 3 h from Tc-99m-albumin nanocolloid cervical injection, all patients underwent SPECT/CT study. MBD was injected into the cervix just before surgery under general anesthesia...
November 4, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27759820/disparities-in-cancer-epidemiology-and-care-delivery-among-brazilian-indigenous-populations
#10
Pedro Nazareth Aguiar, Gustavo Trautman Stock, Gilberto de Lima Lopes, Michelle Samora de Almeida, Hakaru Tadokoro, Bárbara de Souza Gutierres, Douglas Antônio Rodrigues
Objective: To assess aspects related to cancer in indigenous population. Methods: This is a retrospective study developed in a public university hospital. We included patients with 18 or more years of age, diagnosed with solid tumors, and followed between 2005 and 2015. Clinical features were assessed by descriptive statistics, and survival was evaluated by Kaplan-Meier curves and multivariate Cox regression. Results: Fifty patients were included...
July 2016: Einstein
https://www.readbyqxmd.com/read/27747726/post-menopausal-vaginal-hemorrhage-related-to-the-use-of-a-hop-containing-phytotherapeutic-product
#11
Florence van Hunsel, Sonja van de Koppel, Eugène van Puijenbroek
Two 54-year-old women developed abdominal cramps and vaginal hemorrhage as a result of endometrial hyperplasia during treatment with a hop-containing phytotherapeutic product (MenoCool(®)) for post-menopausal complaints. The women used the hop-containing phytotherapeutic product (418 mg of hop per tablet) twice daily (1 and 0.5 tablets by both patient A and B). Patient A developed abdominal cramps and vaginal hemorrhage after 2 months of use. After gynecological examination, she was diagnosed with endometrial hyperplasia...
December 2015: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27678320/cancer-patterns-and-trends-in-central-and-south-america
#12
Mónica S Sierra, Isabelle Soerjomataram, Sébastien Antoni, Mathieu Laversanne, Marion Piñeros, Esther de Vries, David Forman
RATIONALE AND OBJECTIVE: Cancer burden is increasing in Central and South America (CSA). We describe the current burden of cancer in CSA. METHODS: We obtained regional and national-level cancer incidence data from 48 population-based registries (13 countries) and nation-wide cancer mortality data from the WHO (18 countries). We estimated world population age-standardized incidence and mortality rates per 100,000 person-years. RESULTS: The leading cancers diagnosed were prostate, lung, breast, cervix, colorectal, and stomach, which were also the primary causes of cancer mortality...
September 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27648083/implementation-of-image-guided-brachytherapy-igbt-for-patients-with-uterine-cervix-cancer-a-tumor-volume-kinetics-approach
#13
Heloisa de Andrade Carvalho, Lucas Castro Mendez, Silvia Radwanski Stuart, Roger Guilherme Rodrigues Guimarães, Clarissa Cerchi Angotti Ramos, Lucas Assad de Paula, Camila Pessoa de Sales, André Tsin Chih Chen, Roberto Blasbalg, Ronaldo Hueb Baroni
PURPOSE: To evaluate tumor shrinking kinetics in order to implement image-guided brachytherapy (IGBT) for the treatment of patients with cervix cancer. MATERIAL AND METHODS: This study has prospectively evaluated tumor shrinking kinetics of thirteen patients with uterine cervix cancer treated with combined chemoradiation. Four high dose rate brachytherapy fractions were delivered during the course of pelvic external beam radiation therapy (EBRT). Magnetic resonance imaging (MRI) exams were acquired at diagnosis (D), first (B1), and third (B3) brachytherapy fractions...
August 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27555228/image-guided-adaptive-brachytherapy-in-cervix-cancer-a-new-paradigm-changing-clinical-practice-and-outcome
#14
Kari Tanderup, Jacob Christian Lindegaard, Christian Kirisits, Christine Haie-Meder, Kathrin Kirchheiner, Astrid de Leeuw, Ina Jürgenliemk-Schulz, Erik Van Limbergen, Richard Pötter
No abstract text is available yet for this article.
September 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27424443/-vulvar-squamous-cell-carcinoma-in-young-women-with-hpv-negative
#15
A Gómez-Alarcon, M T Gómez-García, J P García-de la-Torre, M Del Valle-Morón, M A Arones-Collantes, G González-de Merlo
BACKGROUND: The vulvar cancer is the fourth more frequent neoplasia after the endometrial, cervix and ovarian cancer. Normally, it has been related to old women of ages from 70 to 80 years old. Rarely, it has been detected cases in adult or young women. However, its incidence has been increased in the last years and in more early years. It is for this change in the incidence and its appearance in early years why a possible etiology has been looked for, opening different hypothesis that go from that related to the HPV to those that study an inflammatory chronic process as the basis for the carcinogenesis...
March 2016: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/27310542/cancer-patients-emergencies-service-and-provision-of-palliative-care
#16
Bruno Miranda, Suely Arruda Vidal, Maria Júlia Gonçalves de Mello, Jurema Telles de Oliveira Lima, Judith Correia Rêgo, Milena Cândido Pantaleão, Viviane Gomes Carneiro Leão, Fernando Antônio Ribeiro de Gusmão, José Iran da Costa
OBJECTIVE: To describe the clinical and sociodemographic profile of cancer patients admitted to the Emergency Center for High Complexity Oncologic Assistance, observing the coverage of palliative and home care. METHOD: Cross sectional study including adult cancer patients admitted to the emergency service (September-December/2011) with a minimum length of hospital stay of two hours. Student's t-test and Pearson chi-square test were used to compare the means. RESULTS: 191 patients were enrolled, 47...
May 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27235711/apoptotic-effect-of-eugenol-envolves-g2-m-phase-abrogation-accompanied-by-mitochondrial-damage-and-clastogenic-effect-on-cancer-cell-in-vitro
#17
Paulo Luiz de Sá Júnior, Diana Aparecida Dias Câmara, André Santos Costa, Jorge Luis Maria Ruiz, Débora Levy, Ricardo Alexandre Azevedo, Kerly Fernanda Mesquita Pasqualoto, Camila Fávero de Oliveira, Thatiana Corrêa de Melo, Nara Diniz Soares Pessoa, Pâmela Maria Moreira Fonseca, Alexandre Pereira, Rodrigo Pinheiro Araldi, Adilson Kleber Ferreira
BACKGROUND: Eugenol (EUG) is a major phenolic compound present in clove whose anti-cancer properties have been demonstrated previously. These anti-cancer properties may involves the modulation of different mechanisms, including α-estrogen receptor (αER) in luminal breast cancer cells, COX-2 inhibition in melanoma cells or p53 and caspase-3 activation in colon cancer cells. HYPOTHESIS: EUG promotes a burst in ROS production causing cell-cycle perturbations, mitochondria toxicity and clastogenesis triggering apoptosis in melanoma breast- and cervix-cancer cells in vitro...
June 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27217888/visual-inspection-with-acetic-acid-and-lugol-s-iodine-in-cervical-cancer-screening-at-the-general-referral-hospital-kayembe-in-mbuji-mayi-democratic-republic-of-congo
#18
Banza Kamba Desire, Cilundika Mulenga Philippe, Kabengele Thierry, Kitenge Wa Momat Félix, Gilbert Utshudienyema Wembodinga, Kakudji Luhete Prosper, Luboya Numbi Oscar
INTRODUCTION: Cervical cancer is the leading cause of morbidity and mortality of women from cancer in the developing World. It is the primary cause of reduced life expectancy in Sub-Saharan countries such as Democratic Republic of Congo. The aim of this work was to determinate the socio-demographic profile of women with precancerous and cancerous lesions of the cervix, to determinate the frequency of VIA and VILI positive cases and to show the challenges that can be faced in managing patients with abnormalities in the city of Mbuji-Mayi in the Democratic Republic of Congo...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27206639/a-phase-i-study-of-mtor-inhibitor-everolimus-in-association-with-cisplatin-and-radiotherapy-for-the-treatment-of-locally-advanced-cervix-cancer-phoenix-i
#19
Andréia Cristina de Melo, Rachele Grazziotin-Reisner, Felipe Erlich, Mariane S Fontes Dias, Giulliana Moralez, Michel Carneiro, Álvaro Henrique Ingles Garces, Flávia Vieira Guerra Alves, Bruna Novaes Neto, Mateus Fuchshuber-Moraes, Juliane Morando, Guilherme Suarez-Kurtz, Carlos Gil Ferreira
BACKGROUND: Cervix cancer (CC) represents the fourth most common cancer in women. Treatment involving cisplatin and radiotherapy has been the standard for locally advanced disease. Everolimus inhibits the aberrant activity of mTOR that is part of carcinogenesis in CC. Further everolimus inactivates the HPV E7 oncoprotein and inhibits its proliferation. Preclinical models have suggested that everolimus sensitizes tumoral cells and vasculature to cisplatin and radiotherapy. METHODS: In a 3 + 3 design, the trial aimed to treat three dose levels of at least three patients with daily doses of everolimus (2...
July 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27199519/evolution-of-radical-hysterectomy-for-cervical-cancer-along-the-last-two-decades-single-institution-experience
#20
Claudia Arispe, Ana Isabel Pomares, Javier De Santiago, Ignacio Zapardiel
BACKGROUND: The radical hysterectomy (RH) surgical technique has improved along the years. It is used for the treatment of cervical cancer, endometrial cancer when affecting the cervix, and upper vaginal carcinomas. Our aim was to describe the historical evolution of the technique after the introduction of laparoscopy at our institution. METHODS: We performed a retrospective review of medical records of patients who underwent RH, grouped in three periods according to the year of surgery: 1990-1999, 2000-2009 and 2010-2013...
April 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
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