keyword
https://read.qxmd.com/read/38524109/-the-timeline-of-the-screening-and-treatment-strategy-of-intraepithelial-neoplasia-of-the-uterine-cervix-adopted-in-morocco
#1
JOURNAL ARTICLE
Mohamed Zraidi, Mohammed Ibriz
In Morocco, the purpose of the National Cancer Prevention and Control Plan (PNPCC) is to decrease the incidence, mortality, and morbidity attributable to cervical cancer (CC), including the general objective which is to improve women´s care by setting up an organized system for screening, early diagnosis and treatment of this disease, and as operational objectives an: 1) achievement of at least 30% of the annual coverage rate by cervical cancer (CC) screening; 2) achievement of at least 80% of the rate of participation in CC screening per screening cycle; 3) achievement of 100% of the treatment rate for precancerous lesions screened within the framework of the program...
2024: Pan African Medical Journal
https://read.qxmd.com/read/38507389/multiscale-optical-imaging-fusion-for-cervical-precancer-diagnosis-integrating-widefield-colposcopy-and-high-resolution-endomicroscopy
#2
JOURNAL ARTICLE
David Brenes, Mila P Salcedo, Jackson B Coole, Yajur Maker, Alex Kortum, Richard A Schwarz, Jennifer Carns, Imran S Vohra, Julio C Possati-Resende, Marcio Antoniazzi, Bruno de Oliveira Fonseca, Karen C Borba Souza, Iara V Vidigal Santana, Flavia Fazzio Barbin, Regis Kreitchmann, Nirmala Ramanujam, Kathleen M Schmeler, Rebecca Richards-Kortum
OBJECTIVE: Early detection and treatment of cervical precancers can prevent disease progression. However, in low-resource communities with a high incidence of cervical cancer, high equipment costs and a shortage of specialists hinder preventative strategies. This manuscript presents a low-cost multiscale in vivo optical imaging system coupled with a computer-aided diagnostic system that could enable accurate, real-time diagnosis of high-grade cervical precancers. METHODS: The system combines portable colposcopy and high-resolution endomicroscopy (HRME) to acquire spatially registered widefield and microscopy videos...
March 20, 2024: IEEE Transactions on Bio-medical Engineering
https://read.qxmd.com/read/38485766/lamin-b1-curtails-early-human-papillomavirus-infection-by-safeguarding-nuclear-compartmentalization-and-autophagic-capacity
#3
JOURNAL ARTICLE
Freya Molenberghs, Marlies Verschuuren, Lauran Vandeweyer, Sarah Peeters, Johannes J Bogers, Claudina Perez Novo, Wim Vanden Berghe, Hans De Reu, Nathalie Cools, Mario Schelhaas, Winnok H De Vos
Human papillomavirus (HPV) infection is a primary cause of cervical and head-and-neck cancers. The HPV genome enters the nucleus during mitosis when the nuclear envelope disassembles. Given that lamins maintain nuclear integrity during interphase, we asked to what extent their loss would affect early HPV infection. To address this question, we infected human cervical cancer cells and keratinocytes lacking the major lamins with a HPV16 pseudovirus (HP-PsV) encoding an EGFP reporter. We found that a sustained reduction or complete loss of lamin B1 significantly increased HP-PsV infection rate...
March 14, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38438182/de-escalation-of-surgical-radicality-for-non-fertility-preserving-management-in-patients-with-early-stage-cervical-cancer-a-systematic-review
#4
JOURNAL ARTICLE
David Viveros-Carreño, Rene Pareja, Marie Plante
OBJECTIVE: We sought to evaluate the oncologic outcomes of simple hysterectomy in patients with low-risk early-stage cervical cancer (tumors ≤2 cm with limited stromal invasion). METHODS: This study was registered in PROSPERO (registration number CRD42023433840) following the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) checklist. MEDLINE (through Ovid), EmMBASEbase, and Cochrane Central Register of Controlled Trials were searched from inception until June 2023...
March 4, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38432435/levels-of-depression-and-self-esteem-in-women-with-cancer-of-the-endometrium-and-cervix-receiving-chemotherapy-treatment-in-t%C3%A3-rkiye
#5
JOURNAL ARTICLE
Selin Kiziltaş, Ekin Dila Topaloğlu Ören
OBJECTIVE: Endometrium and cervical cancer is a common and important health problem that affects women in many physical, emotional and psychological aspects. This study aimed to determine the levels of depression and self-esteem in women with endometrial and cervical cancer receiving chemotherapy, determine the factors affecting them, and examine the relationship between the levels of depression and self-esteem. METHODS: This descriptive and cross-sectional study was conducted with 158 women who came to the gynecology-oncology policlinic and chemotherapy unit of a training and research hospital in Izmir, western Türkiye, between April 2022 and April 2023...
March 1, 2024: Enfermería clínica (English Edition)
https://read.qxmd.com/read/38376334/letter-to-the-editor-of-the-article-carcinoma-cervix-de-novo-with-widespread-cutaneous-subcutaneous-metastasis
#6
JOURNAL ARTICLE
Tiziana Tarcila Laureano Crispin, Andre Juan Fernando Perez Taype
No abstract text is available yet for this article.
October 1, 2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/38269128/small-cell-cervical-carcinoma-in-pregnancy-therapeutic-options-for-an-aggressive-cancer-diagnosis
#7
Alyssa Savelli Binsted, Zeinab Kassem, David Le, Margarita de Veciana
Neuroendocrine small cell cervical carcinoma is an aggressive cancer which accounts for approximately 1 to 3% of all cervical neoplasms. Therapy must be altered in pregnancy to optimize maternal-fetal outcomes. A 39-year-old woman presented for a routine prenatal visit and was noted to have a grossly abnormal cervix. Cervical biopsies confirmed small cell carcinoma. At 19 weeks' gestation, chemotherapy was initiated. The patient delivered at 34 weeks' gestation to initiate radiation therapy. Six months later, she was diagnosed with metastatic disease and died from cancer complications...
January 2024: American Journal of Perinatology Reports
https://read.qxmd.com/read/38251975/adenocarcinoma-in-situ-of-the-uterine-cervix-ais-treated-by-loop-electrosurgical-excision-procedure-strategy-an-observational-study
#8
JOURNAL ARTICLE
Erik Soegaard-Andersen, Anna Poulsgaard Frandsen, Preben Sandahl
OBJECTIVES: Evaluation of the results of treatment of adenocarcinoma in situ by loop electrosurgical excision procedure and the safety of a conservative strategy. METHODS: Identification of all cases of adenocarcinoma in situ treated by loop electrosurgical excision procedure at our institution and follow-up by a conservative strategy. Completeness of the identification of all cases was secured by data from the National Pathology Registry. The treatment strategy was based on cytologic follow-up performed by a general practitioner and, irrespective of margin status of the cone, only the results of the postoperative surveillance were indicative of further treatment...
January 16, 2024: Journal of Lower Genital Tract Disease
https://read.qxmd.com/read/38224619/siss-mco-large-scale-sparsity-induced-spot-selection-for-fast-and-fully-automated-robust-multi-criteria-optimisation-of-proton-plans
#9
JOURNAL ARTICLE
Wens Kong, Michelle Oud, Steven Habraken, Merle Huiskes, Eleftheria Astreinidou, Coen Rasch, Ben J M Heijmen, Sebastiaan Breedveld
Intensity modulated proton therapy (IMPT) is an emerging treatment modality for cancer. However, treatment planning for IMPT is labour-intensive and time-consuming. We have developed a novel approach for multi-criteria optimisation
(MCO) of robust IMPT plans (SISS-MCO) that is fully automated and fast, and we compare it for head and neck, cervix and prostate tumours to a previously published method for automated robust MCO (IPBR-MCO, van de Water 2013).
Approach: In both auto-planning approaches, the applied automated MCO of spot weights was performed with wish-list driven prioritised optimisation (Breedveld 2012)...
January 15, 2024: Physics in Medicine and Biology
https://read.qxmd.com/read/38179550/primary-peritoneal-carcinosarcoma-in-a-breast-cancer-patient-harboring-a-germline-brca2-pathogenic-variant-case-report
#10
Luciana Beatriz Mendes Gomes, Renata Lazari Sandoval, Camila Bragança Xavier, Tatiana Strava Correa, Raquel Midori Koga Matuda, Zenaide Silva de Souza, Luiz Guilherme Cernaglia Aureliano de Lima, Mariana Petaccia de Macedo, Filomena Marino Carvalho, Daniele Assad Suzuki
Malignant mixed müllerian tumor (MMMT) is a rare neoplasm, consisting of carcinomatous (epithelial) and sarcomatous (mesenchymal) components that most commonly arise in the endometrium and more infrequently in the ovaries, fallopian tube, cervix, and vagina. Primary peritoneal carcinosarcoma (PPCS) is an extremely rare extragenital presentation of MMMT. Although the occurrence of breast cancer and epithelial ovarian carcinoma in association with BRCA pathogenic variants is firmly established, the etiologic role of these genes in the development of other tumor types is less well known...
2024: Case Reports in Oncology
https://read.qxmd.com/read/38163774/analysis-of-socio-demographic-risk-factors-of-cervical-intraepithelial-neoplasia-at-colposcopic-clinic-in-mymensingh-medical-college-hospital
#11
JOURNAL ARTICLE
S Choudhoury, T Latif, S Dhar, K Sarker, R Yasmin, A Begum, M K Alamgir, P Das, R Akhter, N S Komola, U R Jahan, M S Khatun, Z Ferdous
Cervical intraepithelial neoplasia (CIN) is a pre-malignant lesion of the cervix of uterus. Several risk factors increased the risk of developing CIN. Purpose of this study was to evaluate the socio-demographic risk factors related to CIN at our setting. This Cross sectional observational study was performed at Colposcopic clinic of Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh from 9th November 2017 to 8th May 2018. Overall demographic features of 50 patients of precancerous cervical lesion show that, most of the patients belonged to the age group 30-39 years (46...
January 2024: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/38117287/melanotic-pecoma-a-rare-but-distinctive-subtype-analyzed-in-a-series-of-7-cases
#12
JOURNAL ARTICLE
Arnaud de la Fouchardiere, David J Papke, Daniel Pissaloux, Eleanor Russell-Goldman, Franck Tirode, Christopher D M Fletcher, John Hanna
Perivascular epithelioid cell neoplasms (PEComas) are tumors of uncertain cell lineage that show a strong female predominance. Their hallmark is the presence of combined smooth muscle and melanocytic differentiation. In most cases, melanocytic differentiation is detectable only by immunohistochemistry, but there are rare reports of PEComa with extensive melanin accumulation (so-called "melanotic PEComa"). Here we report a clinicopathologic series of 7 melanotic PEComas that occurred across a wide patient age range of 21 to 82 years (median: 41 y) and with a wide anatomic distribution, including 2 cases in the pelvis and 1 case each in the gallbladder, cervix, eyelid, epidural space, and femur...
January 1, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/38109131/structure-guided-screening-of-protein-protein-interaction-for-the-identification-of-myc-max-heterodimer-complex-modulators
#13
JOURNAL ARTICLE
Shovonlal Bhowmick, Kunal Roy, Achintya Saha
De-regulation of oncogenic myelocytomatosis (c-Myc or Myc) transcription factor is one of the most common molecular anomalies encountered in human cancers, and it is typically linked to many aggressive malignancies including breast, lung, cervix, colon glioblastomas, and other haematological organs. The Myc belongs to the basic helix-loop-helix zipper protein family (bHLH-ZIP), and its dimerization with another principal interactor protein partner Myc-associated factor X (Max) is essentially required for cellular transformation, cell growth and proliferation, and transcriptional activation...
December 18, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38095881/pembrolizumab-or-placebo-plus-chemotherapy-with-or-without-bevacizumab-for-persistent-recurrent-or-metastatic-cervical-cancer-subgroup-analyses-from-the-keynote-826-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Krishnansu S Tewari, Nicoletta Colombo, Bradley J Monk, Coraline Dubot, M Valeria Cáceres, Kosei Hasegawa, Ronnie Shapira-Frommer, Pamela Salman, Eduardo Yañez, Mahmut Gümüs, Mivael Olivera Hurtado de Mendoza, Vanessa Samouëlian, Vincent Castonguay, Alexander Arkhipov, Cumhur Tekin, Kan Li, Sarper Toker, Stephen M Keefe, Domenica Lorusso
IMPORTANCE: The KEYNOTE-826 randomized clinical trial showed statistically significant and clinically meaningful survival benefits with the addition of pembrolizumab to chemotherapy with or without bevacizumab in patients with persistent, recurrent, or metastatic cervical cancer. Treatment effects in patient subgroups of the study population are unknown. OBJECTIVE: To assess efficacy outcomes in patient subgroups of KEYNOTE-826. DESIGN, SETTING, AND PARTICIPANTS: Exploratory subgroup analyses were conducted in a global, phase 3, randomized, double-blind, placebo-controlled clinical trial...
February 1, 2024: JAMA Oncology
https://read.qxmd.com/read/38087116/benefits-and-harms-of-cervical-screening-triage-and-treatment-strategies-in-women-living-with-hiv
#15
JOURNAL ARTICLE
Michaela T Hall, Kate T Simms, John M Murray, Adam Keane, Diep T N Nguyen, Michael Caruana, Gigi Lui, Helen Kelly, Linda O Eckert, Nancy Santesso, Silvia de Sanjose, Edwin E Swai, Ajay Rangaraj, Morkor Newman Owiredu, Cindy Gauvreau, Owen Demke, Partha Basu, Marc Arbyn, Shona Dalal, Nathalie Broutet, Karen Canfell
To support a strategy to eliminate cervical cancer as a public health problem, the World Health Organisation (WHO) reviewed its guidelines for screening and treatment of cervical pre-cancerous lesions in 2021. Women living with HIV have 6-times the risk of cervical cancer compared to women in the general population, and we harnessed a model platform ('Policy1-Cervix-HIV') to evaluate the benefits and harms of a range of screening strategies for women living with HIV in Tanzania, a country with endemic HIV. Assuming 70% coverage, we found that 3-yearly primary HPV screening without triage would reduce age-standardised cervical cancer mortality rates by 72%, with a number needed to treat (NNT) of 38...
December 2023: Nature Medicine
https://read.qxmd.com/read/38087115/benefits-harms-and-cost-effectiveness-of-cervical-screening-triage-and-treatment-strategies-for-women-in-the-general-population
#16
JOURNAL ARTICLE
Kate T Simms, Adam Keane, Diep Thi Ngoc Nguyen, Michael Caruana, Michaela T Hall, Gigi Lui, Cindy Gauvreau, Owen Demke, Marc Arbyn, Partha Basu, Nicolas Wentzensen, Beatrice Lauby-Secretan, Andre Ilbawi, Raymond Hutubessy, Maribel Almonte, Silvia De Sanjosé, Helen Kelly, Shona Dalal, Linda O Eckert, Nancy Santesso, Nathalie Broutet, Karen Canfell
In 2020, the World Health Organization (WHO) launched a strategy to eliminate cervical cancer as a public health problem. To support the strategy, the WHO published updated cervical screening guidelines in 2021. To inform this update, we used an established modeling platform, Policy1-Cervix, to evaluate the impact of seven primary screening scenarios across 78 low- and lower-middle-income countries (LMICs) for the general population of women. Assuming 70% coverage, we found that primary human papillomavirus (HPV) screening approaches were the most effective and cost-effective, reducing cervical cancer age-standardized mortality rates by 63-67% when offered every 5 years...
December 2023: Nature Medicine
https://read.qxmd.com/read/38066031/reproducible-and-clinically-translatable-deep-neural-networks-for-cervical-screening
#17
JOURNAL ARTICLE
Syed Rakin Ahmed, Brian Befano, Andreanne Lemay, Didem Egemen, Ana Cecilia Rodriguez, Sandeep Angara, Kanan Desai, Jose Jeronimo, Sameer Antani, Nicole Campos, Federica Inturrisi, Rebecca Perkins, Aimee Kreimer, Nicolas Wentzensen, Rolando Herrero, Marta Del Pino, Wim Quint, Silvia de Sanjose, Mark Schiffman, Jayashree Kalpathy-Cramer
Cervical cancer is a leading cause of cancer mortality, with approximately 90% of the 250,000 deaths per year occurring in low- and middle-income countries (LMIC). Secondary prevention with cervical screening involves detecting and treating precursor lesions; however, scaling screening efforts in LMIC has been hampered by infrastructure and cost constraints. Recent work has supported the development of an artificial intelligence (AI) pipeline on digital images of the cervix to achieve an accurate and reliable diagnosis of treatable precancerous lesions...
December 8, 2023: Scientific Reports
https://read.qxmd.com/read/37978580/hpv-related-lesions-after-hysterectomy-for-high-grade-cervical-intraepithelial-neoplasia-and-early-stage-cervical-cancer-a-focus-on-the-potential-role-of-vaccination
#18
JOURNAL ARTICLE
Giorgio Bogani, Francesco Sopracordevole, Andrea Ciavattini, Alessandro Ghelardi, Enrico Vizza, Paolo Vercellini, Jvan Casarin, Ciro Pinelli, Fabio Ghezzi, Rosa De Vincenzo, Violante Di Donato, Tullio Golia D'augè, Andrea Giannini, Flavia Sorbi, Marco Petrillo, Giampiero Capobianco, Giuseppe Vizzielli, Stefano Restaino, Stefano Cianci, Giovanni Scambia, Francesco Raspagliesi
OBJECTIVE: To date, no data supports the execution of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia (CIN2+) and early-stage cervical cancer. We aim to evaluate the potential effect of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia and early-stage cervical cancer. METHODS: This is a multi-center retrospective study evaluating data of women who develop lower genital tract dysplasia (including anal, vulvar and vaginal intra-epithelial neoplasia) after having hysterectomy for CIN2+ and FIGO stage IA1- IB1 cervical cancer...
November 17, 2023: Tumori
https://read.qxmd.com/read/37954220/risk-of-cancer-for-patients-with-rheumatoid-arthritis-versus-general-population-a-national-claims-database-cohort-study
#19
JOURNAL ARTICLE
Maxime Beydon, Sandrine Pinto, Yann De Rycke, Bruno Fautrel, Xavier Mariette, Raphaèle Seror, Florence Tubach
BACKGROUND: Older studies uncovered an increased risk of cancer in patients with rheumatoid arthritis between 10% and 30% compared to the general population, with a lack of data concerning infrequent cancers. In recent year, major therapeutic breakthroughs might have affected this risk of cancer by mitigating disease activity or on the contrary by impairing antitumoral immune response. The objectives of this study are to compare cancer risk in patients with treated rheumatoid arthritis to the general population, in all treated patients and according to treatment exposure...
December 2023: The Lancet regional health. Europe
https://read.qxmd.com/read/37925347/role-of-radiotherapy-in-the-management-of-rare-gynaecological-cancers
#20
REVIEW
R Morcet-Delattre, S Espenel, P Tas, C Chargari, A Escande
There are a large number of gynaecological cancers with rare histologies, for which the available data are limited and usually retrospective. Because of their rarity and poor prognosis, the management of these cancers must be centralized in expert centres, for both histological diagnosis and treatment. With the exception of sarcomas, most endometrial or cervical cancers with rare histologies respond to the same radiation treatment modalities than cancers with more common histologies, although there are some specificities regarding treatments such as neuroendocrine carcinomas (chemotherapy with platinum and etoposide, major role of surgery)...
November 2, 2023: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
keyword
keyword
111800
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.