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cancer de cervix

Louise De Brot, Bruno Pellegrini, Sabrina Teixeira Moretti, Dirce Maria Carraro, Fernando Augusto Soares, Rafael Malagoli Rocha, Glauco Baiocchi, Isabela Werneck da Cunha, Victor Piana de Andrade
BACKGROUND: Infections with multiple human papillomavirus (HPV) types (mHPV) in Papanicolaou tests have been reported but the histologic correlation and clinical meaning remains debatable. METHODS: The authors prospectively tested 37 HPV types using the Linear Array HPV Genotyping Test and correlated the results to cytology and histology findings in 260 women evaluated from June 2009 to October 2011 and followed for up to 60 months. RESULTS: HPV was detected in 148 of 235 samples (63%) and high-risk HPV was detected in 132 samples (56%)...
November 21, 2016: Cancer
Alexandre Buckley de Meritens, Julia Kim, Helen Dinkelspiel, Eloise Chapman-Davis, Thomas Caputo, Kevin Holcomb
Single-site laparoscopy has proven to be a desirable option for patients undergoing gynecologic surgery with some studies indicating improved cosmesis and less perioperative pain compared to standard approaches. This study describes the safety and feasibility of a novel robotic laparo-endoscopic single-site surgery (R-LESS) platform as it is incorporated into a surgeon's practice with extensive multiport robotic surgical experience but limited laparo-endoscopic single-site experience. We reviewed 83 women undergoing R-LESS by a single surgeon from September 2013 through August 2015...
November 17, 2016: Journal of Minimally Invasive Gynecology
Federica Elisei, Cinzia Crivellaro, Daniela Giuliani, Carlotta Dolci, Elena De Ponti, Luca Montanelli, Maria La Manna, Luca Guerra, Maurizio Arosio, Claudio Landoni, Alessandro Buda
OBJECTIVE: The aim of this study was to compare preoperative SPECT/CT with gamma-probe and methylene blue-dye (MBD) in the identification of sentinel lymph node (SLN) in early stage endometrial cancer. METHODS: 40 stage-I EC patients (66.7 ± 9.7 years) underwent preoperative lymphoscintigraphy. After about 3 h from Tc-99m-albumin nanocolloid cervical injection, all patients underwent SPECT/CT study. MBD was injected into the cervix just before surgery under general anesthesia...
November 4, 2016: Annals of Nuclear Medicine
Pedro Nazareth Aguiar, Gustavo Trautman Stock, Gilberto de Lima Lopes, Michelle Samora de Almeida, Hakaru Tadokoro, Bárbara de Souza Gutierres, Douglas Antônio Rodrigues
Objective: To assess aspects related to cancer in indigenous population. Methods: This is a retrospective study developed in a public university hospital. We included patients with 18 or more years of age, diagnosed with solid tumors, and followed between 2005 and 2015. Clinical features were assessed by descriptive statistics, and survival was evaluated by Kaplan-Meier curves and multivariate Cox regression. Results: Fifty patients were included...
July 2016: Einstein
Florence van Hunsel, Sonja van de Koppel, Eugène van Puijenbroek
Two 54-year-old women developed abdominal cramps and vaginal hemorrhage as a result of endometrial hyperplasia during treatment with a hop-containing phytotherapeutic product (MenoCool(®)) for post-menopausal complaints. The women used the hop-containing phytotherapeutic product (418 mg of hop per tablet) twice daily (1 and 0.5 tablets by both patient A and B). Patient A developed abdominal cramps and vaginal hemorrhage after 2 months of use. After gynecological examination, she was diagnosed with endometrial hyperplasia...
December 2015: Drug Safety—Case Reports
Mónica S Sierra, Isabelle Soerjomataram, Sébastien Antoni, Mathieu Laversanne, Marion Piñeros, Esther de Vries, David Forman
RATIONALE AND OBJECTIVE: Cancer burden is increasing in Central and South America (CSA). We describe the current burden of cancer in CSA. METHODS: We obtained regional and national-level cancer incidence data from 48 population-based registries (13 countries) and nation-wide cancer mortality data from the WHO (18 countries). We estimated world population age-standardized incidence and mortality rates per 100,000 person-years. RESULTS: The leading cancers diagnosed were prostate, lung, breast, cervix, colorectal, and stomach, which were also the primary causes of cancer mortality...
September 2016: Cancer Epidemiology
Heloisa de Andrade Carvalho, Lucas Castro Mendez, Silvia Radwanski Stuart, Roger Guilherme Rodrigues Guimarães, Clarissa Cerchi Angotti Ramos, Lucas Assad de Paula, Camila Pessoa de Sales, André Tsin Chih Chen, Roberto Blasbalg, Ronaldo Hueb Baroni
PURPOSE: To evaluate tumor shrinking kinetics in order to implement image-guided brachytherapy (IGBT) for the treatment of patients with cervix cancer. MATERIAL AND METHODS: This study has prospectively evaluated tumor shrinking kinetics of thirteen patients with uterine cervix cancer treated with combined chemoradiation. Four high dose rate brachytherapy fractions were delivered during the course of pelvic external beam radiation therapy (EBRT). Magnetic resonance imaging (MRI) exams were acquired at diagnosis (D), first (B1), and third (B3) brachytherapy fractions...
August 2016: Journal of Contemporary Brachytherapy
Kari Tanderup, Jacob Christian Lindegaard, Christian Kirisits, Christine Haie-Meder, Kathrin Kirchheiner, Astrid de Leeuw, Ina Jürgenliemk-Schulz, Erik Van Limbergen, Richard Pötter
No abstract text is available yet for this article.
September 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
A Gómez-Alarcon, M T Gómez-García, J P García-de la-Torre, M Del Valle-Morón, M A Arones-Collantes, G González-de Merlo
BACKGROUND: The vulvar cancer is the fourth more frequent neoplasia after the endometrial, cervix and ovarian cancer. Normally, it has been related to old women of ages from 70 to 80 years old. Rarely, it has been detected cases in adult or young women. However, its incidence has been increased in the last years and in more early years. It is for this change in the incidence and its appearance in early years why a possible etiology has been looked for, opening different hypothesis that go from that related to the HPV to those that study an inflammatory chronic process as the basis for the carcinogenesis...
March 2016: Ginecología y Obstetricia de México
Bruno Miranda, Suely Arruda Vidal, Maria Júlia Gonçalves de Mello, Jurema Telles de Oliveira Lima, Judith Correia Rêgo, Milena Cândido Pantaleão, Viviane Gomes Carneiro Leão, Fernando Antônio Ribeiro de Gusmão, José Iran da Costa
OBJECTIVE: To describe the clinical and sociodemographic profile of cancer patients admitted to the Emergency Center for High Complexity Oncologic Assistance, observing the coverage of palliative and home care. METHOD: Cross sectional study including adult cancer patients admitted to the emergency service (September-December/2011) with a minimum length of hospital stay of two hours. Student's t-test and Pearson chi-square test were used to compare the means. RESULTS: 191 patients were enrolled, 47...
May 2016: Revista da Associação Médica Brasileira
Paulo Luiz de Sá Júnior, Diana Aparecida Dias Câmara, André Santos Costa, Jorge Luis Maria Ruiz, Débora Levy, Ricardo Alexandre Azevedo, Kerly Fernanda Mesquita Pasqualoto, Camila Fávero de Oliveira, Thatiana Corrêa de Melo, Nara Diniz Soares Pessoa, Pâmela Maria Moreira Fonseca, Alexandre Pereira, Rodrigo Pinheiro Araldi, Adilson Kleber Ferreira
BACKGROUND: Eugenol (EUG) is a major phenolic compound present in clove whose anti-cancer properties have been demonstrated previously. These anti-cancer properties may involves the modulation of different mechanisms, including α-estrogen receptor (αER) in luminal breast cancer cells, COX-2 inhibition in melanoma cells or p53 and caspase-3 activation in colon cancer cells. HYPOTHESIS: EUG promotes a burst in ROS production causing cell-cycle perturbations, mitochondria toxicity and clastogenesis triggering apoptosis in melanoma breast- and cervix-cancer cells in vitro...
June 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Banza Kamba Desire, Cilundika Mulenga Philippe, Kabengele Thierry, Kitenge Wa Momat Félix, Gilbert Utshudienyema Wembodinga, Kakudji Luhete Prosper, Luboya Numbi Oscar
INTRODUCTION: Cervical cancer is the leading cause of morbidity and mortality of women from cancer in the developing World. It is the primary cause of reduced life expectancy in Sub-Saharan countries such as Democratic Republic of Congo. The aim of this work was to determinate the socio-demographic profile of women with precancerous and cancerous lesions of the cervix, to determinate the frequency of VIA and VILI positive cases and to show the challenges that can be faced in managing patients with abnormalities in the city of Mbuji-Mayi in the Democratic Republic of Congo...
2016: Pan African Medical Journal
Andréia Cristina de Melo, Rachele Grazziotin-Reisner, Felipe Erlich, Mariane S Fontes Dias, Giulliana Moralez, Michel Carneiro, Álvaro Henrique Ingles Garces, Flávia Vieira Guerra Alves, Bruna Novaes Neto, Mateus Fuchshuber-Moraes, Juliane Morando, Guilherme Suarez-Kurtz, Carlos Gil Ferreira
BACKGROUND: Cervix cancer (CC) represents the fourth most common cancer in women. Treatment involving cisplatin and radiotherapy has been the standard for locally advanced disease. Everolimus inhibits the aberrant activity of mTOR that is part of carcinogenesis in CC. Further everolimus inactivates the HPV E7 oncoprotein and inhibits its proliferation. Preclinical models have suggested that everolimus sensitizes tumoral cells and vasculature to cisplatin and radiotherapy. METHODS: In a 3 + 3 design, the trial aimed to treat three dose levels of at least three patients with daily doses of everolimus (2...
July 2016: Cancer Chemotherapy and Pharmacology
Claudia Arispe, Ana Isabel Pomares, Javier De Santiago, Ignacio Zapardiel
BACKGROUND: The radical hysterectomy (RH) surgical technique has improved along the years. It is used for the treatment of cervical cancer, endometrial cancer when affecting the cervix, and upper vaginal carcinomas. Our aim was to describe the historical evolution of the technique after the introduction of laparoscopy at our institution. METHODS: We performed a retrospective review of medical records of patients who underwent RH, grouped in three periods according to the year of surgery: 1990-1999, 2000-2009 and 2010-2013...
April 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Camila Silva Boaventura, José Lucas Scarpinetti Galvão, Giovanna Milanes Bego Soares, Almir Galvão Vieira Bitencourt, Rubens Chojniak, Shenia Lauanna Rezende Bringel, Louise De Brot
Endometrial and cervical cancers are the most prevalent gynecologic neoplasms. While endometrial cancer occurs in older women, cervical cancer is more prevalente in young subjects. The most common clinical manifestation in these two gynecological cancers is vaginal bleeding. In the first case, diagnosis is made based on histological and imaging evaluation of the endometrium, while cervical cancers are diagnosed clinically, according to the International Federation of Gynecology and Obstetrics (FIGO). The authors present a case of synchronous gynecological cancer of the endometrium and cervix diagnosed during staging on MRI and confirmed by histological analysis of the surgical specimen...
April 2016: Revista da Associação Médica Brasileira
Natália de Carvalho Scharf Santana, Natália Alves Lima, Vânia Cristina Desoti, Danielle Lazarin Bidóia, Patrícia de Souza Bonfim Mendonça, Bianca Altrão Ratti, Tânia Ueda Nakamura, Celso Vataru Nakamura, Marcia Edilaine Lopes Consolaro, Valdecir Farias Ximenes, Sueli de Oliveira Silva
PURPOSE: Cervical cancer is characterized as an important public health problem. According to latest estimates, cancer of the cervix is the fourth most common cancer among women. Due to its high prevalence, the search for new and efficient drugs to treat this infection is continuous. The progression of HPV-associated cervical cancer involves the expression of two viral proteins, E6 and E7, which are rapidly degraded by the ubiquitin-proteasome system through the increase in reactive oxygen species generation...
October 2016: Archives of Gynecology and Obstetrics
A Marijne Heeren, Simone Punt, Maaike Cg Bleeker, Katja N Gaarenstroom, Jacobus van der Velden, Gemma G Kenter, Tanja D de Gruijl, Ekaterina S Jordanova
Programmed death-ligand 1 (PD-L1) is expressed in various immune cells and tumor cells, and is able to bind to PD-1 on T lymphocytes, thereby inhibiting their function. At present, the PD-1/PD-L1 axis is a major immunotherapeutic target for checkpoint inhibition in various cancer types, but information on the clinical significance of PD-L1 expression in cervical cancer is largely lacking. Here, we studied PD-L1 expression in paraffin-embedded samples from two cohorts of patients with cervical cancer: primary tumor samples from cohort I (squamous cell carcinoma, n=156 and adenocarcinoma, n=49) and primary and paired metastatic tumor samples from cohort II (squamous cell carcinoma, n=96 and adenocarcinoma, n=31)...
July 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Mehmet Turkeli, Melih Simsek, Mehmet Naci Aldemir, Nilgun Yildirim, Erdem Cankaya, Burak Erdemci, Mehmet Bilici, Salim Basol Tekin, Sukru Arslan, Ercan Korkut
OBJECTIVE: Our aim is to evaluate the frequency and characteristics of cancer in the population of patients with solid organ transplant who are under immunosuppressive medication. In this study we aimed to emphasize the importance of early diagnosis of cancer in solid organ transplant recipients. An aging population began to receive solid organ transplantation and survival times prolonged. But this had a cost and new problems came forward. Especially de novo cancers because of immunosuppressive therapy took notice...
February 2016: Eurasian Journal of Medicine
Steffie K Naber, Inge M C M de Kok, Suzette M Matthijsse, Marjolein van Ballegooijen
BACKGROUND: It is well acknowledged that HPV testing should not be performed at young age and at short intervals. Cytological screening practices have shown that over-screening, i.e., from a younger age and at shorter intervals than recommended, is hard to avoid. We quantified the consequences of a switch to primary HPV screening for over-screened women, taking into account its higher sensitivity but lower specificity than cytology. METHODS: The health effects of using the HPV test instead of cytology as the primary screening method were determined with the MISCAN-Cervix model...
April 2016: Cancer Causes & Control: CCC
A Boers, R Wang, R W van Leeuwen, H G Klip, G H de Bock, H Hollema, W van Criekinge, T de Meyer, S Denil, A G J van der Zee, E Schuuring, G B A Wisman
BACKGROUND: Assessment of DNA promoter methylation markers in cervical scrapings for the detection of cervical intraepithelial neoplasia (CIN) and cervical cancer is feasible, but finding methylation markers with both high sensitivity as well as high specificity remains a challenge. In this study, we aimed to identify new methylation markers for the detection of high-grade CIN (CIN2/3 or worse, CIN2+) by using innovative genome-wide methylation analysis (MethylCap-seq). We focused on diagnostic performance of methylation markers with high sensitivity and high specificity considering any methylation level as positive...
2016: Clinical Epigenetics
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