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Neurocardiogenic syncope

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https://www.readbyqxmd.com/read/29119462/syncope-in-pediatric-practice
#1
REVIEW
Pratibha Singhi, Arushi Gahlot Saini
Syncope is defined as a sudden, self-limited loss of consciousness and postural tone followed by spontaneous and complete recovery without any neurological sequelae. It is one of the most common paroxysmal disorders in children and adolescents. The three major causes of syncope in children are neural, cardiovascular and other non-cardiovascular causes. The common unifying mechanism is transient global hypoperfusion of the brain. The diagnosis is primarily clinical and objective laboratory investigations add little to the diagnosis in children especially in neurocardiogenic subtype...
November 9, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28925543/stressful-medical-explanation-may-cause-syncope-in-patients-with-emotion-triggered-neurocardiogenic-syncope
#2
Kazuhiro Kato, Yosuke Kakisaka, Kazutaka Jin, Mayu Fujikawa, Miki Nakamura, Natsumi Suzuki, Masateru Kondo, Koji Fukuda, Hiroaki Shimokawa, Nobukazu Nakasato
No abstract text is available yet for this article.
September 19, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28895151/role-of-closed-loop-stimulation-pacing-cls-in-vasovagal-syncope
#3
REVIEW
Mohammed Ruzieh, Zaid Ammari, Osama Dasa, Saima Karim, Blair Grubb
Vasovagal syncope (VVS) or neurocardiogenic syncope is defined by transient loss of consciousness with spontaneous and rapid recovery. Recently, a closed loop stimulation (CLS) pacing system has emerged as a new strategy which appears superior to conventional pacing for patients with refractory syncope. However, its efficacy remains of considerable debate and large randomized controlled clinical trials are needed. Between 2002 and 2017, 12 total studies evaluated the use of CLS pacing in patients with refractory VVS, and are summarized in this article...
September 12, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28816725/effect-of-citalopram-for-the-treatment-of-neurocardiogenic-syncope
#4
Amer N Kadri, Leen Nusairat, Samah Kadri, Ammar Alqaid, Adrian V Hernandez, Nazih N Kadri
BACKGROUND: Neurocardiogenic syncope (NCS) is a common form of syncope. Although selective serotonin reuptake inhibitors and other medications have been used to treat NCS with variable success, there is no consensus regarding a first-line therapy. STUDY QUESTION: To assess the effects of citalopram in NCS and to examine the effect of diagnostic use of the head-up tilt table (HUTT) versus empirical diagnosis on patient outcome. STUDY DESIGN: A retrospective case series of 1000 consecutive patients who were diagnosed with NCS and treated with citalopram...
August 16, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28616731/renal-nerve-stimulation-for-treatment-of-neurocardiogenic-syncope-a-review-from-perspective-of-commercialization-potential
#5
REVIEW
B O'Brien, H Zafar, F Sharif
A strong evidence of outcomes for vasovagal syncope is not easily identified. It would seem reasonable that the proposed Mayo Clinic technology would be reserved for cases with severe recurrent or refractory syncope. However, recurrence levels are relatively low, and while some predictive methods have been proposed, recurrence is also influenced by the interaction that occurs during screening and examinations, i.e. recurrence diminishes once an initial diagnosis has been made. Finally, a key factor in being able to identify suitable patients relates to understanding the relative significance of the vasodepression and cardioinhibitory components-the therapy is best suited to patients that have a significant level of both components...
June 14, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28055999/-role-of-the-sympathetic-nervous-system-in-vasovagal-syncope-and-rationale-for-beta-blockers-and-norepinephrine-transporter-inhibitors
#6
REVIEW
Manlio F Márquez, Jorge Rafael Gómez-Flores, Jesús A González-Hermosillo, Teresita de Jesús Ruíz-Siller, Manuel Cárdenas
Vasovagal or neurocardiogenic syncope is a common clinical situation and, as with other entities associated with orthostatic intolerance, the underlying condition is a dysfunction of the autonomic nervous system. This article reviews various aspects of vasovagal syncope, including its relationship with orthostatic intolerance and the role of the autonomic nervous system in it. A brief history of the problem is given, as well as a description of how the names and associated concepts have evolved. The response of the sympathetic system to orthostatic stress, the physiology of the baroreflex system and the neurohumoral changes that occur with standing are analyzed...
December 29, 2016: Medwave
https://www.readbyqxmd.com/read/28045689/racial-differences-in-response-to-tilt-table-testing-in-patients-refered
#7
Jameel Ahmed, Peerawut Deeprasertkul, Kevin M Monahan, Paul LeLorier
BACKGROUND: Syncope is a common problem in the general population and results in significant societal and patient costs. Several small studies have demonstrated differences in orthostatic response, and possibly tolerance, between blacks and whites. Based on these observations, we retrospectively reviewed results from our tilt table database to identify potential differences in response to tilt-table testing with regards to race, between black and white patients. METHODS: The reports of 446 tilt-table tests performed on adults, older than 18 years of age, at Boston Medical Center, an urban, tertiary-care, academic hospital, were reviewed...
November 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27959743/autologous-adipose-stem-cell-therapy-for-autonomic-nervous-system-dysfunction-in-two-young-patients
#8
Mohammed T Numan, Ankur Kamdar, Jane Young, Ian J Butler
Postural orthostatic tachycardia syndrome and neurocardiogenic syncope are clinical manifestations of autonomic nervous system dysfunction (dysautonomia) that can lead to impaired daily functions. We report two young patients presenting with dysautonomia and autoimmune disease who both received autologous adipose stem cells (ASCs) infusions. This report is the first description of ASCs therapy for patients with combined dysautonomia and autoimmune disease. Case 1: A 21-year-old female presented at 12 years of age with escalating severe dysautonomia with weight loss and gastrointestinal symptoms...
March 15, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/27895693/p-wave-dispersion-on-12-lead-electrocardiography-in-adolescents-with-neurocardiogenic-syncope
#9
Dong-Hyuk Lee, Kyung-Min Lee, Jung-Min Yoon, Jae-Woo Lim, Kyung-Ok Kho, Hong-Ryang Kil, Eun-Jung Cheon
PURPOSE: Neurocardiogenic syncope (NCS) is the most frequent cause of fainting during adolescence. Inappropriate cardiovascular autonomic control may be responsible for this clinical event. The head-up tilt test has been considered a diagnostic standard, but it is cumbersome and has a high false-positive rate. We performed a study to evaluate whether P-wave dispersion (PWD) could be a useful electrocardiographic parameter of cardiac autonomic dysfunction in children with NCS. METHODS: Fifty-four patients with NCS (28 boys and 26 girls; mean age, 12...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27891259/neurocardiogenic-syncope-and-supraventricular-tachycardia-in-association-with-a-rare-congenital-aortic-valve-abnormality
#10
Yashwant Agrawal, Jagadeesh K Kalavakunta, Vishal Gupta, William Lapenna
We report a case of a 26-year-old woman who presented with multiple episodes of syncope over a five-months period of time. Transthoracic echocardiogram had shown a normal functioning quadricuspid aortic valve (QAV) which was also confirmed on a transesophageal echocardiogram. Computed tomographic angiography of heart and coronary arteries showed the QAV with equal size of all aortic cusps and normal coronary arteries. Intermittent chest pain and palpitations warranted an exercise stress test. The stress test revealed normal aerobic exertion, with achievement of 101% of maximal peak heart rate...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27559316/cerebro-and-cardio-vascular-responses-to-energy-drink-in-young-adults-is-there-a-gender-effect
#11
Cathríona R Monnard, Jean-Pierre Montani, Erik K Grasser
BACKGROUND AND PURPOSE: Energy drinks (EDs) are suspected to induce potential adverse cardiovascular effects and have recently been shown to reduce cerebral blood flow velocity (CBFV) in young, healthy subjects. Gender differences in CBFV in response to EDs have not previously been investigated, despite the fact that women are more prone to cardiovascular disturbances such as neurocardiogenic syncope than men. Therefore, the aim of this study was to explore gender differences in cerebrovascular and cardiovascular responses to EDs...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27349042/-results-of-autonomic-testing-in-children-with-migraine-with-aura-including-visual-and-sensory
#12
Aleksandra Gergont, Beata Gajda, Ewa Wesołowska
BACKGROUND: Despite the signs of involvement of autonomic nervous system (ANS) in the pathomechanism of migraine, the significance of its dysfunction was not fully explained. One of parameters serving to establish a balance of both ANS parts is relation of low frequency (LF) to high frequency (HF) heart rate variability (HRV), LF/ HF ratio. HF reflects parasympathetic activity, whereas LF both sympathetic and parasympathetic as well as respiratory rhythm. AIMS: The aims of the study was to establish LF and HF ratio in children with migraine with aura, during rest, passive tilting and also during active standing...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27349039/-cerebral-blood-flow-during-neurocardiogenic-syncopes-in-children
#13
Aleksandra Gergont, Katarzyna Kurdziel, Urszula Stolarska-Weryńska
BACKGROUND: Neurocardiogenic syncope, the most common episodic event in children results from global cerebral hypoperfusion. Monitoring of the blood flow during head-up tilt-induced syncope resulted in registration of preferential reduction of end-diastolic velocities in middle cerebral arteries (MCA). The significance of those changes was however not explained. The aim of this retrospective research was to establish the significance of visual inspection of spectra changes of cerebral blood flow in MCA during presyncope and syncope in children...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27217962/an-unusual-case-of-asystole-occurring-during-deep-brain-stimulation-surgery
#14
Ha Son Nguyen, Harvey Woehlck, Peter Pahapill
Background. Symptomatic bradycardia and hypotension in neurosurgery can produce severe consequences if not managed appropriately. The literature is scarce regarding its occurrence during deep brain stimulation (DBS) surgery. Case Presentation. A 67-year-old female presented for left DBS lead placement for essential tremors. During lead implantation, heart rate and blood pressure dropped rapidly; the patient became unresponsive and asystolic. Chest compressions were initiated and epinephrine was given. Within 30 seconds, the patient became hemodynamically stable and conscious...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27188269/what-factors-influence-parents-perception-of-the-quality-of-life-of-children-and-adolescents-with-neurocardiogenic-syncope
#15
COMPARATIVE STUDY
Teresa Grimaldi Capitello, Caterina Fiorilli, Silvia Placidi, Roberta Vallone, Fabrizio Drago, Simonetta Gentile
BACKGROUND: Health-related quality of life, which can be investigated using self-reports or parental reports, could help healthcare providers understand the subjective perception of well-being of children suffering from recurrent syncopal episodes. Quality of life is not only a measure of health but is also a reflection of patients' and parents' perceptions and expectations of health. This study assessed: 1) the consistency and agreement between pediatric patients' self-reports and parents' proxy-reports of their child's quality of life; 2) whether this patient-parent agreement is dependent on additional demographic and clinical or distress factors; 3) whether the parents' psychological distress influences children's and parents' responses to questionnaires on quality of life...
May 17, 2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27156083/genome-wide-association-study-of-copy-number-variations-in-patients-with-familial-neurocardiogenic-syncope
#16
Emre Demir, Can Hasdemir, Handan Ak, Sevcan Atay, Hikmet Hakan Aydin
Neurocardiogenic syncope (NCS) is the most frequent type of syncope characterized by a self-limited episode of systemic hypotension. In this study, we conducted the first genome-wide association study testing copy number variations for association with NCS. Study population consisted of 107 consecutive patients with recurrent syncope and positive head-up tilt table testing. Four families with NCS were selected for CNV analysis. Affymetrix GeneChip(®) SNP 6.0 array was used for CNV analysis. Data and statistical analysis were performed with Affymetrix genotyping console 4...
August 2016: Biochemical Genetics
https://www.readbyqxmd.com/read/27098073/searching-for-the-cause-of-syncope-non-sustained-ventricular-tachycardia-or-neurocardiogenic-syndrome-does-it-really-need-lengthy-investigation
#17
Krzysztof Błaszyk, Adrian Gwizdała, Wojciech Seniuk, Michał Waśniewski, Stefan Grajek
No abstract text is available yet for this article.
2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27022459/tilt-table-test-today-state-of-the-art
#18
REVIEW
Nicholay Teodorovich, Moshe Swissa
A tilt table test (TTT) is an inexpensive, noninvasive tool for the differential diagnosis of syncope and orthostatic intolerance and has good diagnostic yield. The autonomic system malfunction which underlines the reflex syncope is manifested as either hypotension or bradycardia, while an orthostatic challenge is applied. The timing of the response to the orthostatic challenge, as well as the predominant component of the response help to differentiate between various forms of neurocardiogenic syncope, orthostatic hypotension and non-cardiovascular conditions (e...
March 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27008695/blood-pressure-variability-and-baroreflex-sensitivity-of-a-healthy-male-during-cold-pressor-test-that-induced-development-of-neurocardiogenic-syncope
#19
Biswajit Sinha, Dinesh K Dubey
BACKGROUND: The cold pressor test (CPT) is a recognized physiological technique to evaluate autonomic cardiovascular function. The present case study assessed the cardiovascular response of a healthy adult male during 3 min of CPT. METHODS: Heart rate (HR) by single-lead electrocardiography and blood pressure (BP) by an arterial tonometer of the participant on a beat-to-beat basis were recorded before and during CPT. RESULTS: HR during CPT showed a biphasic pattern with an initial increase from baseline (86 bpm) to the first 30 s of CPT (93 bpm) followed by a decrease...
June 1, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/26937921/hyperoxia-improves-hemodynamic-status-during-head-up-tilt-testing-in-healthy-volunteers-a-randomized-study
#20
RANDOMIZED CONTROLLED TRIAL
Julien Fromonot, Guillaume Chaumet, Olivier Gavarry, Jean-Claude Rostain, Michel Lucciano, Fabrice Joulia, Michele Brignole, Jean-Claude Deharo, Regis Guieu, Alain Boussuges
Head-up tilt test is useful for exploring neurally mediated syncope. Adenosine is an ATP derivative implicated in cardiovascular disturbances that occur during head-up tilt test. The aim of the present study was to investigate the impact of hyperoxia on adenosine plasma level and on hemodynamic changes induced by head-up tilt testing.Seventeen healthy male volunteers (mean age 35 ± 11 years) were included in the study. The experiment consisted of 2 head-up tilt tests, 1 session with subjects breathing, through a mask, medical air (FiO2 = 21%) and 1 session with administration of pure oxygen (FiO2 = 100%) in double-blind manner...
February 2016: Medicine (Baltimore)
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