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https://www.readbyqxmd.com/read/28099806/melting-behavior-of-zipper-structured-lipopeptides-in-lipid-bilayer
#1
Sijia Wang, Xia Han, Danyang Liu, Mengya Li, Shouhong Xu, Honglai Liu
A zipper-structured lipopeptide is expected to play a role of "intelligent valve" in the lipid bilayer. In this paper, a series of zipper-structured lipopeptides have been designed for preparing thermo-controllable hybrid liposomes. Their conformational transition as a function of temperature in lipid bilayer has been investigated for understanding the influences of molecular structure and bilayer property on bio-function. The melting temperatures Tm of the lipopeptides have been found to depend on their molecular structures...
January 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28088738/piperine-modulates-isoproterenol-induced-myocardial-ischemia-through-antioxidant-and-anti-dyslipidemic-effect-in-male-wistar-rats
#2
Velumani Dhivya, Lohanathan Bharathi Priya, Hilda T Chirayil, Swamiappan Sathiskumar, Chih-Yang Huang, Viswanadha Vijaya Padma
Myocardial infarction due to ischemia accounts for majority of deaths among cardiovascular disorders. Isoproterenol (ISO) induced myocardial infarction and the protection offered by piperine was investigated in the present report. Lipid profile analysis by determining the levels of cholesterol, phospholipids, triglycerides and lipoproteins in serum and heart tissues showed anti-dyslipidemic action of piperine against ISO induced myocardial injury by modulating the ISO induced altered lipid profiles, maintaining to near control values...
January 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28076803/drunken-membranes-short-chain-alcohols-alter-fusion-of-liposomes-to-planar-lipid-bilayers
#3
Jason Paxman, Brady Hunt, David Hallan, Samuel R Zarbock, Dixon J Woodbury
Although the effects of ethanol on protein receptors and lipid membranes have been studied extensively, ethanol's effect on vesicles fusing to lipid bilayers is not known. To determine the effect of alcohols on fusion rates, we utilized the nystatin/ergosterol fusion assay to measure fusion of liposomes to a planar lipid bilayer (BLM). The addition of ethanol excited fusion when applied on the cis (vesicle) side, and inhibited fusion on the trans side. Other short-chain alcohols followed a similar pattern. In general, the inhibitory effect of alcohols (trans) occurs at lower doses than the excitatory (cis) effect, with a decrease of 29% in fusion rates at the legal driving limit of 0...
January 10, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28075574/visualization-of-mycobacterial-membrane-dynamics-in-live-cells
#4
Frances P Rodriguez-Rivera, Xiaoxue Zhou, Julie A Theriot, Carolyn R Bertozzi
Mycobacteria are endowed with a highly impermeable mycomembrane that confers intrinsic resistance to many antibiotics. Several unique mycomembrane glycolipids have been isolated and structurally characterized, but the underlying organization and dynamics of glycolipids within the cell envelope remain poorly understood. We report here a study of mycomembrane dynamics that was enabled by trehalose-fluorophore conjugates capable of labeling trehalose glycolipids in live actinomycetes. We identified fluorescein-trehalose analogs that are metabolically incorporated into the trehalose mycolates of representative Mycobacterium, Corynebacterium, Nocardia and Rhodococcus species...
January 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28074943/the-influence-of-flaxseed-gum-on-the-microrheological-properties-and-physicochemical-stability-of-whey-protein-stabilized-%C3%AE-carotene-emulsions
#5
Duoxia Xu, Yameng Qi, Xu Wang, Xin Li, Shaojia Wang, Yanping Cao, Chengtao Wang, Baoguo Sun, Eric Decker, Atikorn Panya
The impact of flaxseed gum (FG) on the microrheological properties and physicochemical stability of whey protein isolate (WPI) stabilized β-carotene emulsions at pH 3.0 was studied. A layer-by-layer electrostatic deposition method was used to prepare multilayered β-carotene emulsions with interfacial membranes consisting of WPI and FG. The microrheological behavior of the multilayered β-carotene emulsions was measured through the diffusive wave spectroscopy technique. WPI alone and WPI-FG (concentration of FG = 0...
January 11, 2017: Food & Function
https://www.readbyqxmd.com/read/28073184/functional-lipidomics-palmitic-acid-impairs-hepatocellular-carcinoma-development-by-modulating-membrane-fluidity-and-glucose-metabolism
#6
Ling Lin, Ying Ding, Yi Wang, Zhenxin Wang, Xuefei Yin, Guoquan Yan, Lei Zhang, Pengyuan Yang, Huali Shen
: Lipids are essential cellular components and energy sources of living organisms, altered lipid composition is increasingly recognized as a signature of cancer. We performed the lipidomic analysis in a series of hepatocellular carcinoma (HCC) cells and identified over 1700 intact lipids originating from 3 major lipid categories. Comparative lipidomic screening revealed 93 significantly changed lipids and decreased palmitic acyl (C16:0)-containing glycerophospholipids (GPs) were positively associated with metastatic abilities of HCC cells...
January 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28069415/silymarin-exerts-antifungal-effects-via-membrane-targeted-mode-of-action-by-increasing-permeability-and-inducing-oxidative-stress
#7
Dae Gyu Yun, Dong Gun Lee
Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver disorders. It is also consumed as a dietary supplement to improve liver function, as it does not exhibit any toxic effects in humans. Recently, silymarin has been reported to show antimicrobial effects against various pathogenic microorganisms, but the mode of action remains unknown. Thus, we investigated the antifungal activity of silymarin and aimed to determine the underlying mechanism. Initially, a propidium iodide assay was carried out; the results indicated that silymarin induced injury to the fungal plasma membrane...
January 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28058428/incorporation-of-aspirin-modulates-the-dynamical-and-phase-behavior-of-the-phospholipid-membrane
#8
V K Sharma, E Mamontov, M Ohl, M Tyagi
Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used medications in the world for their analgesic, antipyretic, and anti-inflammatory actions, despite a well-known incidence of a wide spectrum of their adverse effects. To a great extent, beneficial action and side effects of NSAIDs are associated with the interaction of these drugs at the cell membrane level. Here, we use neutron scattering to combine elastic intensity scans, quasielastic and neutron spin echo (NSE) measurements to understand the effect of aspirin, a commonly used NSAID, on the dynamical and phase behavior of the membrane of dimyristoylphosphatidylcholine (DMPC), a prominent representative of phospholipids residing in the outer leaflet of the human erythrocyte membrane...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28043371/sperm-bound-antisperm-antibodies-prevent-capacitation-of-bovine-spermatozoa
#9
M S Ferrer, J Klabnik-Bradford, D E Anderson, A C Bullington, R A Palomares, L M J Miller, R Stawicki, M Miesner
It was hypothesized here that sperm-bound antisperm antibodies (ASAs) impair the ability of bovine spermatozoa to undergo capacitation, bind to the zona pellucida, and complete the acrosome reaction. The effect of ASA binding on these functions was evaluated in frozen/thawed spermatozoa from four bulls before and after induction of ASAs. Ejaculates were divided into ASA negative (<10% immunoglobulin [Ig]G- and IgA-bound spermatozoa) or ASA positive (≥20% IgG and/or IgA-bound spermatozoa). The percentage of capacitated (Merocyanine 540 positive) live spermatozoa in response to heparin was lower in ASA-positive than ASA-negative ejaculates (P < 0...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28039536/cardiolipin-in-central-nervous-system-physiology-and-pathology
#10
REVIEW
Caitlin B Pointer, Andis Klegeris
Cardiolipin, an anionic phospholipid found primarily in the inner mitochondrial membrane, has many well-defined roles within the peripheral tissues, including the maintenance of mitochondrial membrane fluidity and the regulation of mitochondrial functions. Within the central nervous system (CNS), cardiolipin is found within both neuronal and non-neuronal glial cells, where it regulates metabolic processes, supports mitochondrial functions, and promotes brain cell viability. Furthermore, cardiolipin has been shown to act as an elimination signal and participate in programmed cell death by apoptosis of both neurons and glia...
December 30, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28036299/v-atpase-inhibition-increases-cancer-cell-stiffness-and-blocks-membrane-related-ras-signaling-a-new-option-for-hcc-therapy
#11
Karin Bartel, Maria Winzi, Melanie Ulrich, Andreas Koeberle, Dirk Menche, Oliver Werz, Rolf Müller, Jochen Guck, Angelika M Vollmar, Karin von Schwarzenberg
Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide and the third leading cause of cancer-related death. However, therapy options are limited leaving an urgent need to develop new strategies. Currently, targeting cancer cell lipid and cholesterol metabolism is gaining interest especially regarding HCC. High cholesterol levels support proliferation, membrane-related mitogenic signaling and increase cell softness, leading to tumor progression, malignancy and invasive potential. However, effective ways to target cholesterol metabolism for cancer therapy are still missing...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28029520/ultrasonic-nanoemulsification-of-food-grade-trans-cinnamaldehyde-1-8-cineol-and-investigation-of-the-mechanism-of-antibacterial-activity
#12
Roya Moghimi, Atousa Aliahmadi, Hasan Rafati
Using ultrasonic technology, trans-cinnamaldehyde as a natural antibacterial compound was used to prepare nano size emulsions to increase its bioavailability and therefore bactericidal action. Nanoemulsions containing trans-cinnamaldehyde as an active agent and 1,8 cineol as co additive oil (Ostwald ripening inhibitor) were formulated using probe sonicator. Three different determining factors, namely time of sonication, surfactant to oil ratio and type of emulsifier (Tween 80 and Tween 20) were investigated to enhance the stability profile...
October 22, 2016: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28012884/erythrocytes-properties-in-varicose-veins-patients
#13
L Gwozdzinski, A Pieniazek, J Bernasinska, M Grabowski, E Kowalczyk, K Gwozdzinski
Varicose veins (VV) are enlarged veins of the subcutaneous tissue, usually caused by faulty or damaged venous valves leading to impaired blood flow. Blood stasis, excessive clotting disorder and alterations in the vein walls are symptoms of Virchow's triad which may affect the morphotic elements of blood, including erythrocytes. The aim of this study was to investigate alterations in the properties of the erythrocytes taken from varicose veins in comparison to those from antecubital vein of patients with chronic venous disease...
December 21, 2016: Microvascular Research
https://www.readbyqxmd.com/read/28007479/membrane-interactions-of-natural-cyclic-lipodepsipeptides-of-the-viscosin-group
#14
Niels Geudens, Mehmet Nail Nasir, Jean-Marc Crowet, Jos M Raaijmakers, Krisztina Fehér, Tom Coenye, José C Martins, Laurence Lins, Davy Sinnaeve, Magali Deleu
Many Pseudomonas spp. produce cyclic lipodepsipeptides (CLPs), which, besides their role in biological functions such as motility, biofilm formation and interspecies interactions, are antimicrobial. It has been established that interaction with the cellular membrane is central to the mode of action of CLPs. In this work, we focus on the CLPs of the so-called viscosin group, aiming to assess the impact of the main structural variations observed within this group on both the antimicrobial activity and the interaction with model membranes...
December 20, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27991638/modulation-of-phase-separation-at-the-micron-scale-and-nanoscale-in-giant-polymer-lipid-hybrid-unilamellar-vesicles-ghuvs
#15
Thi Phuong Tuyen Dao, Fabio Fernandes, Emmanuel Ibarboure, Khalid Ferji, Manuel Prieto, Olivier Sandre, Jean-François Le Meins
Phase separation in giant polymer/lipid hybrid unilamellar vesicles (GHUVs) has been described over the last few years. However there is still a lack of understanding on the physical and molecular factors governing the phase separation in such systems. Among these parameters it has been suggested that in analogy to multicomponent lipid vesicles hydrophobic mismatches as well as lipid fluidity play a role. In this work, we aim to map a global picture of phase separation and domain formation in the membrane of GHUVs by using various copolymers based on poly(dimethylsiloxane) (PDMS) and poly(ethylene glycol) (PEO) with different architectures (grafted, triblock) and molar masses, combined with phospholipids in the fluid (POPC) or gel state (DPPC) at room temperature...
January 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/27988521/inhibitors-of-acetylcholinesterase-derived-from-7-methoxytacrine-and-their-effects-on-the-choline-transporter-cht1
#16
Zdenka Kristofikova, Jan Ricny, Ondrej Soukup, Jan Korabecny, Eugenie Nepovimova, Kamil Kuca, Daniela Ripova
BACKGROUND: Reversible acetylcholinesterase inhibitors are used in Alzheimer disease therapy. However, tacrine and its derivatives have severe side effects. Derivatives of the tacrine analogue 7-methoxytacrine (MEOTA) are less toxic. METHODS: We evaluated new derivatives of 7-MEOTA (2 homodimers linked by 2 C4-C5 chains and 5 N-alkylated C4-C8 side chain derivatives) in vitro, using the rat hippocampal choline transporter CHT1. RESULTS: Some derivatives were effective inhibitors of rat acetylcholinesterase and comparable with 7-MEOTA...
December 17, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27987312/comparison-of-cytotoxic-activity-in-leukemic-lineages-reveals-important-features-of-%C3%AE-hairpin-antimicrobial-peptides
#17
Marcus V Buri, Heron F Vieira Torquato, Carlos Castilho Barros, Jaime S Ide, Antonio Miranda, Edgar J Paredes-Gamero
Several reports described different modes of cell death triggered by antimicrobial peptides (AMPs) due to direct effects on membrane disruption, and more recently by apoptosis and necrosis-like patterns. Cytotoxic curves of four β-hairpin AMPs (gomesin, protegrin, tachyplesin, and polyphemusin) were obtained from several human leukemic lineages and normal monocytes and Two cell lines were then selected based on their cytotoxic sensitivity. One was sensitive to AMPs (K562) and the other resistant (KG-1) and their effect compared between these lineages...
December 17, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27983976/saturated-fatty-acid-in-the-phospholipid-monolayer-contributes-to-the-formation-of-large-lipid-droplets
#18
Kotoko Arisawa, Haruka Mitsudome, Konomi Yoshida, Shizuka Sugimoto, Tomoko Ishikawa, Yoko Fujiwara, Ikuyo Ichi
The degree of saturation of fatty acid chains in the bilayer membrane structure is known to control membrane fluidity and packing density. However, the significance of fatty acid composition in the monolayers of lipid droplets (LDs) has not been elucidated. In this study, we noted a relationship between the size of LDs and the fatty acid composition of the monolayer. To obtain large LDs, we generated NIH3T3 cells overexpressing fat-specific protein 27 (FSP27). This induced the fusion of LDs, resulting in larger LDs in FSP27-overexpressing cells compared with LDs in control cells...
October 27, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27974465/dynamic-lipid-dependent-modulation-of-protein-topology-by-post-translational-phosphorylation
#19
Heidi Vitrac, David M MacLean, Anja Karlstaedt, Heinrich Taegtmeyer, Vasanthi Jayaraman, Mikhail Bogdanov, William Dowhan
Membrane protein topology and folding are governed by structural principles and topogenic signals that are recognized and decoded by the protein insertion and translocation machineries at the time of initial membrane insertion and folding. We previously demonstrated that lipid environment is also a determinant of initial protein topology, which is dynamically responsive to post-assembly changes in membrane lipid composition. However, the effect on protein topology of post-assembly phosphorylation of amino acids localized within initially cytoplasmically oriented extramembrane domains has never been investigated...
December 14, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27965586/the-antioxidant-peroxiredoxin-6-prdx6-exhibits-different-profiles-in-the-livers-of-seawater-and-fresh-water-acclimated-milkfish-chanos-chanos-upon-hypothermal-challenge
#20
Chia-Hao Chang, Wan-Yu Lo, Tsung-Han Lee
A tropical species, the euryhaline milkfish (Chanos chanos), is a crucial economic species in Southeast Asia and is intolerant of water temperature below 12°C. Large numbers of milkfish die during cold periods in winter. Hypothermal environments usually increase oxidative stress in teleosts, and the liver is the major organ for anti-oxidative responses in the body. Peroxiredoxin-6 (Prdx6) in mammals is a multi-functional enzyme and acts as both glutathione peroxidase, phospholipase A2 and acyl-transferase for maintenance of redox status and prevention of cell membrane peroxidation...
2016: Frontiers in Physiology
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