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https://www.readbyqxmd.com/read/27914092/synthesis-characterization-and-study-of-in-vitro-cytotoxicity-of-zno-fe3o4-magnetic-composite-nanoparticles-in-human-breast-cancer-cell-line-mda-mb-231-and-mouse-fibroblast-nih-3t3
#1
Gunjan Bisht, Sagar Rayamajhi, Biplab Kc, Siddhi Nath Paudel, Deepak Karna, Bhupal G Shrestha
Novel magnetic composite nanoparticles (MCPs) were successfully synthesized by ex situ conjugation of synthesized ZnO nanoparticles (ZnO NPs) and Fe3O4 NPs using trisodium citrate as linker with an aim to retain key properties of both NPs viz. inherent selectivity towards cancerous cell and superparamagnetic nature, respectively, on a single system. Successful characterization of synthesized nanoparticles was done by XRD, TEM, FTIR, and VSM analyses. VSM analysis showed similar magnetic profile of thus obtained MCPs as that of naked Fe3O4 NPs with reduction in saturation magnetization to 16...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27912914/distribution-and-source-analysis-of-heavy-metals-in-soils-and-sediments-of-yueqing-bay-basin-east-china-sea
#2
Xiaohui Yang, Pengbao Wu, Aijing Yin, Huan Zhang, Ming Zhang, Chao Gao
Concentrations of heavy metals in coastal soils, stream sediments and intertidal sediments of Yueqing Bay basin were analyzed to study their distribution and trace the possible sources. According to various single- and multi-index methods, heavy metal enrichment, especially for Cu, Zn, Cr and Ni in stream sediments, should draw environmental concern. Controlling factors such as inorganic scavengers, organic matter, sample grain size and hydrodynamic conditions were identified to influence the transportation and distribution of metals within coastal soils and sediments...
November 29, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27910335/detailed-characterization-of-the-llnl-imaging-proton-spectrometer
#3
A M Rasmus, A U Hazi, M J-E Manuel, C C Kuranz, S R Klein, P X Belancourt, J R Fein, M J MacDonald, R P Drake, B B Pollock, J Park, G J Williams, H Chen
Ultra-intense short pulse lasers incident on solid targets (e.g., thin Au foils) produce well collimated, broad-spectrum proton beams. These proton beams can be used to characterize magnetic fields, electric fields, and density gradients in high energy-density systems. The LLNL-Imaging Proton Spectrometer (L-IPS) was designed and built [H. Chen et al., Rev. Sci. Instrum. 81, 10D314 (2010)] for use with such laser produced proton beams. The L-IPS has an energy range of 50 keV-40 MeV with a resolving power (E/dE) of about 275 at 1 MeV and 21 at 20 MeV, as well as a single spatial imaging axis...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909706/out-of-plane-integration-of-a-multimode-optical-fiber-for-single-particle-cell-detection-at-multiple-points-on-a-microfluidic-device-with-applications-to-particle-cell-counting-velocimetry-size-discrimination-and-the-analysis-of-single-cell-lysate-injections
#4
Jalal Sadeghi, Damith E W Patabadige, Anne H Culbertson, Hamid Latifi, Christopher T Culbertson
In this paper a single particle/cell-tracking microfluidic device that integrates an out-of-plane multimode optical fiber (OP-MMF) is reported. This OP-MMF is used to generate three excitation light-lines and three detection spots using only one excitation source and one detector. It takes advantage of an optical tunneling mode to create two excitation lines in a microfluidic channel emanating from a single fiber end. This method was used to accurately count particles/cells and perform velocity measurements and size discrimination...
December 2, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27908170/high-resolution-digital-autoradiographic-and-dosimetric-analysis-of-heterogeneous-radioactivity-distribution-in-xenografted-prostate-tumors
#5
Oskar V Timmermand, Jenny Nilsson, Sven-Erik Strand, Jörgen Elgqvist
PURPOSE: The first main aim of this study was to illustrate the absorbed dose rate distribution from (177)Lu in sections of xenografted prostate cancer (PCa) tumors using high resolution digital autoradiography (DAR) and compare it with hypothetical identical radioactivity distributions of (90)Y or 7 MeV alpha-particles. Three dosimetry models based on either dose point kernels or Monte Carlo simulations were used and evaluated. The second and overlapping aim, was to perform DAR imaging and dosimetric analysis of the distribution of radioactivity, and hence the absorbed dose rate, in tumor sections at an early time point after injection during radioimmunotherapy using (177)Lu-h11B6, directed against the human kallikrein 2 antigen...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27908097/molecular-dynamics-analysis-of-the-effect-of-electronic-polarization-on-the-structure-and-single-particle-dynamics-of-mixtures-of-ionic-liquids-and-lithium-salts
#6
Volker Lesch, Hadrián Montes-Campos, Trinidad Méndez-Morales, Luis Javier Gallego, Andreas Heuer, Christian Schröder, Luis M Varela
We report a molecular dynamics study on the effect of electronic polarization on the structure and single-particle dynamics of mixtures of the aprotic ionic liquid 1-ethyl-3-methylimidazolium bis-(trifluoromethylsulfonyl)-imide ([EMIM][TFSI]) doped with a lithium salt with the same anion at 298 K and 1 bar. In particular, we analyze the effect of electron density fluctuations on radial distribution functions, velocity autocorrelation functions, cage correlation functions, mean-squared displacements, and vibrational densities of states, comparing the predictions of the quantum-chemistry-based Atomistic Polarizable Potential for Liquids, Electrolytes, & Polymers (APPLE&P) with those of its nonpolarizable version and those of the standard non-polarizable Optimized Potentials for Liquid Simulations-All Atom (OPLS-AA)...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27906306/substrate-surface-patterning-by-optical-near-field-modulation-around-colloidal-particles-immersed-in-a-liquid
#7
M Ulmeanu, P Petkov, D Ursescu, F Jipa, R Harniman, E Brousseau, M N R Ashfold
Optical near field enhancements in the vicinity of particles illuminated by laser light are increasingly recognized as a powerful tool for nanopatterning applications, but achieving sub-wavelength details from the near-field distribution remains a challenge. Here we present a quantitative analysis of the spatial modulation of the near optical fields generated using single 8 ps, 355 nm (and 532 nm) laser pulses around individual colloidal particles and small close packed arrays of such particles on silicon substrates...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906145/nitrobacter-sp-extract-mediated-biosynthesis-of-ag2o-nps-with-excellent-antioxidant-and-antibacterial-potential-for-biomedical-application
#8
Gopalu Karunakaran, Matheswaran Jagathambal, Alexander Gusev, Nguyen Van Minh, Evgeny Kolesnikov, Arup Ratan Mandal, Denis Kuznetsov
In this study, extracellular extract of plant growth promoting bacterium, Nitrobacter sp. is used for the bioconversion of AgNO3 (silver nitrate) into Ag2O (silver oxide nanoparticles). It is an easy, ecofriendly and single step method for Ag2O NPs synthesis. The bio-synthesized nanoparticles were characterized using different techniques. UV-Vis results showed the maximum absorbance around 450 nm. XRD result shows the particles to have faced centered cubic (fcc) crystalline nature. FTIR analysis reveals the functional groups that are involved in bioconversion such as C-N, N-H and C=O...
December 2016: IET Nanobiotechnology
https://www.readbyqxmd.com/read/27899526/dynamic-pre-bcr-homodimers-fine-tune-autonomous-survival-signals-in-b-cell-precursor-acute-lymphoblastic-leukemia
#9
M Frank Erasmus, Ksenia Matlawska-Wasowska, Ichiko Kinjyo, Avanika Mahajan, Stuart S Winter, Li Xu, Michael Horowitz, Diane S Lidke, Bridget S Wilson
The pre-B cell receptor (pre-BCR) is an immature form of the BCR critical for early B lymphocyte development. It is composed of the membrane-bound immunoglobulin (Ig) heavy chain, surrogate light chain components, and the signaling subunits Igα and Igβ. We developed monovalent quantum dot (QD)-labeled probes specific for Igβ to study the behavior of pre-BCRs engaged in autonomous, ligand-independent signaling in live B cells. Single-particle tracking revealed that QD-labeled pre-BCRs engaged in transient, but frequent, homotypic interactions...
November 29, 2016: Science Signaling
https://www.readbyqxmd.com/read/27886760/practical-limitations-of-single-particle-icp-ms-in-the-determination-of-nanoparticle-size-distributions-and-dissolution-case-of-rare-earth-oxides
#10
Laurie Fréchette-Viens, Madjid Hadioui, Kevin J Wilkinson
The applicability of single particle ICP-MS (SP-ICP-MS) for the analysis of nanoparticle size distributions and the determination of particle numbers was evaluated using the rare earth oxide, La2O3, as a model particle. The composition of the storage containers, as well as the ICP-MS sample introduction system were found to significantly impact SP-ICP-MS analysis. While La2O3 nanoparticles (La2O3 NP) did not appear to interact strongly with sample containers, adsorptive losses of La(3+)(over 24h) were substantial (>72%) for fluorinated ethylene propylene bottles as opposed to polypropylene (<10%)...
January 15, 2017: Talanta
https://www.readbyqxmd.com/read/27886401/not-all-that-glitters-is-gold-electron-microscopy-study-on-uptake-of-gold-nanoparticles-in-daphnia-magna-and-related-artefacts
#11
Louise Helene Søgaard Jensen, Lars Michael Skjolding, Amalie Thit, Sara Nørgaard Sørensen, Carsten Købler, Kristian Mølhave, Anders Baun
Increasing use of engineered nanoparticles has led to extensive research into their potential hazards to the environment and human health. Cellular uptake from the gut is sparsely investigated and microscopy techniques applied for uptake studies can result in misinterpretations. Various microscopy techniques are used to investigate internalization of 10 nm gold nanoparticles in Daphnia magna gut lumen and gut epithelial cells upon 24h exposure and outline potential artefacts, i.e. high contract precipitates from sample preparation related to these techniques...
November 25, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27886050/design-of-fresnel-lens-type-multi-trapping-acoustic-tweezers
#12
You-Lin Tu, Shih-Jui Chen, Yean-Ren Hwang
In this paper, acoustic tweezers which use beam forming performed by a Fresnel zone plate are proposed. The performance has been demonstrated by finite element analysis, including the acoustic intensity, acoustic pressure, acoustic potential energy, gradient force, and particle distribution. The acoustic tweezers use an ultrasound beam produced by a lead zirconate titanate (PZT) transducer operating at 2.4 MHz and 100 Vpeak-to-peak in a water medium. The design of the Fresnel lens (zone plate) is based on air reflection, acoustic impedance matching, and the Fresnel half-wave band (FHWB) theory...
November 23, 2016: Sensors
https://www.readbyqxmd.com/read/27886001/strategy-for-the-hemocompatibility-testing-of-microparticles
#13
S Braune, S Basu, K Kratz, J Bäckemo Johansson, M Reinthaler, A Lendlein, F Jung
Polymer-based microparticles are applied as non-thrombogenic or thrombogenic materials in a wide variety of intra- or extra-corporeal medical devices. As demanded by the regulatory agencies, the hemocompatibility of these blood contacting biomaterials has to be evaluated in vitro to ensure that the particle systems appropriately fulfill the envisioned function without causing undesired events such as thrombosis or inflammation. Currently described in vitro assays for hemocompatibility testing of particles comprise tests with different single cell types (e...
November 23, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27884686/intraarterial-lidocaine-for-pain-control-in-uterine-artery-embolization-a-prospective-randomized-study
#14
Maxime Noel-Lamy, Kong T Tan, Martin E Simons, Kenneth W Sniderman, Oleg Mironov, Dheeraj K Rajan
PURPOSE: To assess efficacy of two different techniques of lidocaine injection in the uterine arteries to reduce pain following uterine artery embolization (UAE) for leiomyomas. MATERIALS AND METHODS: This prospective randomized single-blinded study was performed with 60 patients enrolled between November 2014 and December 2015 equally randomized to 3 arms. Group A received 10 mL lidocaine 1% (100 mg) mixed with polyvinyl alcohol particles (355-500 μm). Group B received the same dose of lidocaine injected after embolization...
November 21, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27883891/analysis-of-cell-lineage-trees-by-exact-bayesian-inference-identifies-negative-autoregulation-of-nanog-in-mouse-embryonic-stem-cells
#15
Justin Feigelman, Stefan Ganscha, Simon Hastreiter, Michael Schwarzfischer, Adam Filipczyk, Timm Schroeder, Fabian J Theis, Carsten Marr, Manfred Claassen
Many cellular effectors of pluripotency are dynamically regulated. In principle, regulatory mechanisms can be inferred from single-cell observations of effector activity across time. However, rigorous inference techniques suitable for noisy, incomplete, and heterogeneous data are lacking. Here, we introduce stochastic inference on lineage trees (STILT), an algorithm capable of identifying stochastic models that accurately describe the quantitative behavior of cell fate markers observed using time-lapse microscopy data collected from proliferating cell populations...
November 23, 2016: Cell Systems
https://www.readbyqxmd.com/read/27869281/solution-self-assembly-of-plasmonic-janus-nanoparticles
#16
Nicolò Castro, Doru Constantin, Patrick Davidson, Benjamin Abécassis
Janus nanoparticles bearing two different properties on a single particle are amenable to self-assembly into higher-order structures via their directional interaction. We show that gold/silica Janus nanoparticles self-assemble in solution into clusters resembling colloidal micelles upon addition of a hydrophobic thiol which provides them with a surface active amphiphilic character. As the nanoparticles spontaneously assemble, the color of the solution evolves due to the coupling of the surface plasmons. Time resolved spectrophotometry in the visible and near-infrared ranges coupled to simulations were used to probe the assembly process...
November 21, 2016: Soft Matter
https://www.readbyqxmd.com/read/27866880/efficacy-of-sterile-fecal-filtrate-transfer-for-treating-patients-with-clostridium-difficile-infection
#17
Stephan J Ott, Georg H Waetzig, Ateequr Rehman, Jacqueline Moltzau-Anderson, Richa Bharti, Juris A Grasis, Liam Cassidy, Andreas Tholey, Helmut Fickenscher, Dirk Seegert, Philip Rosenstiel, Stefan Schreiber
BACKGROUND & AIMS: Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We investigated whether sterile fecal filtrates (containing bacterial debris, proteins, antimicrobial compounds, metabolic products and oligonucleotides/DNA), rather than intact microorganisms, are effective in patients with CDI...
November 17, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27856196/a-fabric-phase-sorptive-extraction-high-performance-liquid-chromatography-photo-diode-array-detection-method-for-the-determination-of-twelve-azole-antimicrobial-drug-residues-in-human-plasma-and-urine
#18
Marcello Locatelli, Abuzar Kabir, Denise Innosa, Teresa Lopatriello, Kenneth G Furton
This paper reports a novel fabric phase sorptive extraction-high performance liquid chromatography-photodiode array detection (FPSE-HPLC-PDA) method for the simultaneous extraction and analysis of twelve azole antimicrobial drug residues that include ketoconazole, terconazole, voriconazole, bifonazole, clotrimazole, tioconazole, econazole, butoconazole, miconazole, posaconazole, ravuconazole, and itraconazole in human plasma and urine samples. The selected azole antimicrobial drugs were well resolved by using a Luna C18 column (250mm×4...
November 11, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27856136/korean-multicenter-registry-of-transcatheter-arterial-chemoembolization-with-drug-eluting-embolic-agents-for-nodular-hepatocellular-carcinomas-six-month-outcome-analysis
#19
Myungsu Lee, Jin Wook Chung, Kwang-Hun Lee, Jong Yun Won, Ho Jong Chun, Han Chu Lee, Jin Hyoung Kim, In Joon Lee, Saebeom Hur, Hyo-Cheol Kim, Yoon Jun Kim, Gyoung Min Kim, Seung-Moon Joo, Jung Suk Oh
PURPOSE: To assess the efficacy and safety of transcatheter arterial chemoembolization with drug-eluting embolic (DEE) agents for nodular hepatocellular carcinoma (HCC). MATERIALS AND METHODS: The study design was a prospective multicenter registry-based, single-arm clinical trial that included 152 patients. One hundred three (67.8%) had a Child-Pugh class/score of A5, 114 (75.0%) had a performance status of 0, and 77 (50.7%) had Barcelona Clinic Liver Cancer (BCLC) stage A disease...
November 14, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27853737/validation-of-diagnostic-characteristics-of-needle-based-confocal-laser-endomicroscopy-in-differentiation-of-pancreatic-cystic-lesions
#20
Somashekar G Krishna, Benjamin Swanson, Phil A Hart, Samer El-Dika, Jon P Walker, Sean T McCarthy, Ahmad Malli, Zarine K Shah, Darwin L Conwell
: Background and aims: Endoscopic ultrasound (EUS)-guided needle-based Confocal Laser Endomicroscopy (nCLE) characteristics of pancreatic cystic lesions (PCLs) have been identified in studies where the gold standard surgical histopathology was available in a minority of patients. There are diverging reports of interobserver agreement (IOA) and paucity of intraobserver reliability (IOR). Thus, we sought to validate current EUS-nCLE criteria of PCLs in a larger consecutive series of surgical patients...
November 2016: Endoscopy International Open
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