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risperidone hyperprolactinemia

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https://www.readbyqxmd.com/read/27871720/-guidelines-for-the-prescription-of-mood-stabilizers-for-adolescents-a-literature-review
#1
G Munch, N Godart
INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different efficacy and tolerance profiles compared to those at other stages of the lifespan. Mood stabilizers are a complex pharmacological category including lithium, some anticonvulsants, and some second generation antipsychotics. Focusing on this class of pharmacological agents, we aim to answer the following questions: in which indications and according to which modalities should mood stabilizers be prescribed during adolescence? METHODS: Information was sought from the websites of the French Haute Autorité de santé (HAS) and Agence nationale de sécurité du médicament et des produits de santé (ANSM), the American Food and Drug Administration (FDA) and the British National Institute for Health and Clinical Excellence (NICE)...
November 18, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27829454/prolactin-related-symptoms-during-risperidone-maintenance-treatment-results-from-a-prospective-multicenter-study-of-schizophrenia
#2
Qijing Bo, Fang Dong, Xianbin Li, Zhimin Wang, Xin Ma, Chuanyue Wang
BACKGROUND: This study aimed to investigate prolactin related symptoms (PRS) in individuals with schizophrenia during risperidone maintenance treatment for one year, as well as to identify the risk factors for PRS. METHODS: In a multicenter, randomized, controlled, longitudinal study, clinically stabilized schizophrenia patients (N = 374) were randomized to a no-dose-reduction group (N = 129) and 4-week (N = 125) and 26-week (N = 120) reduction groups, in which the original dose was followed by a 50 % reduction over 8 weeks and subsequently maintained...
November 9, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27823949/risk-of-breast-cancer-in-risperidone-users-a-nationwide-cohort-study
#3
Johan Reutfors, Louise Wingård, Lena Brandt, Yiting Wang, Hong Qiu, Helle Kieler, Shahram Bahmanyar
BACKGROUND: Several antipsychotics, especially risperidone, are known to increase serum prolactin. Hyperprolactinemia has been linked to the development of mammary gland tumors in animal studies. We therefore investigated the risk of breast cancer in a nationwide cohort of women using risperidone or other antipsychotics. METHODS: All women, 18years or older, who initiated treatment with risperidone or any other antipsychotic between 2006 and 2012 were identified in Swedish nationwide registers...
November 4, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27639124/hyperprolactinemia-prolactin-related-side-effects-and-quality-of-life-in-chinese-psychiatric-patients
#4
Feng-Rong An, Rui Yang, Zhi-Min Wang, Gabor S Ungvari, Chee H Ng, Helen F K Chiu, Ping-Ping Wu, Xin Jin, Lu Li, Grace K I Lok, Yu-Tao Xiang
PURPOSE: To examine the frequency of hyperprolactinemia and the socio-demographic, clinical, and quality of life (QOL) correlates. The frequency of prolactin-related side effects and associated subjective experiences were also examined. METHODS: A cohort of 1364 psychiatric inpatients were consecutively recruited and evaluated. Basic socio-demographic and clinical data were collected. Psychopathology, prolactin-related side effects were measured using standardized instruments...
November 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27111215/relation-between-serum-prolactin-levels-and-antipsychotic-response-to-risperidone-in-patients-with-schizophrenia
#5
Alladi Charan, Deepak Gopal Shewade, Ravi Philip Rajkumar, Adithan Chandrasekaran
BACKGROUND: Hyperprolactinemia is commonly seen in patients with schizophrenia on risperidone. Dopamine receptor blockade plays a major role in risperidone induced hyperprolactinemia. However, limited studies are available with inconsistent results on antipsychotic response to risperidone and prolactin elevation. Therefore, we aimed to study the change in serum prolactin levels and response to risperidone and to test the association between DRD2 genetic variants and prolactin levels in schizophrenic patients treated with risperidone...
June 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27010188/prolactin-and-macroprolactin-levels-in-psychiatric-patients-receiving-atypical-antipsychotics-a-preliminary-study
#6
Young-Min Park, Seung-Hwan Lee, Bun-Hee Lee, Kyu Young Lee, Kye-Seong Lee, Seung-Gul Kang, Hwa-Young Lee, Won Kim
The aims of this study were to clarify whether atypical antipsychotics can elevate serum levels of both macroprolactin and prolactin, and whether the macroprolactin levels differ according to the type of atypical antipsychotic being taken. In total, 245 subjects were enrolled consecutively in 6 hospitals. Serum prolactin and macroprolactin levels were measured at a single time point during maintenance antipsychotic monotherapy. The mean total serum prolactin levels including macroprolactin were 11.91, 20.73, 16...
May 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/26978050/-plasma-levels-of-antipsychotics-and-the-severity-of-side-effects-in-the-treatment-of-schizophrenia-exacerbation
#7
S S Potanin, D S Burminsky, M A Morozova, A I Platova, N V Baymeeva, I I Miroshnichenko
OBJECTIVE: To study a relationship between plasma levels of antipsychotics (AP) and severity of side-effects (SE) during the treatment of inpatients with exacerbation of schizophrenia. MATERIAL AND METHODS: The study included 39 patients treated with risperidone, haloperidol, zuclopenthixol, clozapine, aripiprazole or olanzapine as monotherapy or in combination of two AP. Blood sampling to measure the AP plasma level was performed twice (at 7-10 and 26-30 day from start of treatment), the levels of prolactin and glucose were determined once (at 26-30 day from start of treatment)...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/26923999/-aripiprazole-gambling-disorder-and-compulsive-sexuality
#8
D Mété, C Dafreville, V Paitel, P Wind
INTRODUCTION: Aripiprazole, an atypical or second-generation antipsychotic, is usually well tolerated. It is an approved treatment for schizophrenia and mania in bipolar disorder type 1. Unlike the other antipsychotics, it has high affinity agonist properties for dopamine D2 and D3 receptors. It has also 5-HT1A partial agonist and 5-HT2A antagonist properties. Aripiprazole is a first or second line treatment frequently used because it has reduced side effects such as weight gain, sleepiness, dyslipidemia, insulin resistance, hyperprolactinemia and extrapyramidal symptoms...
June 2016: L'Encéphale
https://www.readbyqxmd.com/read/26921057/add-on-effects-of-a-low-dose-aripiprazole-in-resolving-hyperprolactinemia-induced-by-risperidone-or-paliperidone
#9
Ying Qiao, Fuzhong Yang, Chunbo Li, Qian Guo, Hui Wen, Suoyu Zhu, Qiong Ouyang, Weidi Shen, Jianhua Sheng
This study investigated the effects of a low-dose aripiprazole adjunctive treatment for risperidone- or paliperidone-induced hyperprolactinemia in Han Chinese women with schizophrenia. After 4 weeks of risperidone or paliperidone treatment, 60 out of 66 patients improved significantly and experienced hyperprolactinemia. They were randomly assigned to the treatment group (aripiprazole adjunctive treatment) (n=30) or control group (non-adjunctive treatment) (n=30). The dosage of risperidone and paliperidone were maintained; and aripiprazole was maintained at 5mg/day during the 8-week study period...
March 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/26894929/serum-ferritin-weight-gain-disruptive-behavior-and-extrapyramidal-symptoms-in-risperidone-treated-youth
#10
Chadi A Calarge, Daryl J Murry, Ekhard E Ziegler, L Eugene Arnold
BACKGROUND: Iron deficiency disrupts dopaminergic signaling in rodents, resulting in cognitive deficits that may be reversed with psychostimulants. In humans, iron deficiency with or without anemia has similarly been found to cause neuropsychological and behavioral impairments. However, the clinical effects of low body iron stores in antipsychotic-treated children have not been examined. METHODS: Medically healthy, 5- to 17-year-old boys treated with risperidone for at least 1 year were enrolled between February 2009 and November 2013 in a multiphase study, examining the skeletal effects of calcium and vitamin D supplementation in risperidone-induced hyperprolactinemia...
June 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26872113/impact-of-pharmacogenetic-markers-of-cyp2d6-and-drd2-on-prolactin-response-in-risperidone-treated-thai-children-and-adolescents-with-autism-spectrum-disorders
#11
Chonlaphat Sukasem, Yaowaluck Hongkaew, Nattawat Ngamsamut, Apichaya Puangpetch, Natchaya Vanwong, Montri Chamnanphon, Bhunnada Chamkrachchangpada, Ananya Sinrachatanant, Penkhae Limsila
OBJECTIVE: The aim of the study was to identify the impact of pharmacogenetic markers associated with prolactin concentration in risperidone-treated children and adolescents with autism spectrum disorders. METHODS: One hundred forty-seven children and adolescents with autism, aged 3 to 19 years, received risperidone. The clinical data of patients were recorded from medical records. Prolactin levels were measured by chemiluminescence immunoassay. Three CYP2D6 single nucleotide polymorphisms, CYP2D6*4 (1846G>A), *10 (100C>T), and *41 (2988G>A), 1 gene deletion (*5), and DRD2 Taq1A (rs1800497) polymorphism were genotyped by TaqMan real-time polymerase chain reaction...
April 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/26682995/hyperprolactinemia-in-children-and-adolescents-with-use-of-risperidone-clinical-and-molecular-genetics-aspects
#12
Amilton dos Santos Júnior, Taciane Barbosa Henriques, Maricilda Palandi de Mello, Adriana Perez Ferreira Neto, Lúcia Arisaka Paes, Osmar Henrique Della Torre, Letícia Esposito Sewaybricker, Thiago Salum Fontana, Eloisa Helena Rubello Valler Celeri, Gil Guerra Júnior, Paulo Dalgalarrondo
OBJECTIVE: In children and adolescents treated with risperidone, hyperprolactinemia is a frequent complication that may have clinical repercussions. Several genes have been associated with this occurrence. The aim of this study was to evaluate the frequency of hyperprolactinemia in children and adolescents treated with risperidone, and its associations with clinical and pharmacological data and certain polymorphisms of the following genes: Dopamine receptor D2 (DRD2), 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C), cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), leptin (LEP), leptin receptor (LEPR), melanocortin 4 receptor (MC4R), and scavenger receptor class B, member 2 (SCARB2)...
December 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26664488/clozapine-and-risperidone-influence-on-cortisol-and-estradiol-levels-in-male-patients-with-schizophrenia
#13
G Piriu, E Torac, L E Gaman, L Iosif, I C Tivig, C Delia, M Gilca, I Stoian, V Atanasiu
Estrogens role in schizophrenia patients is a subject, which has gained an increased attention from the medical community. Estrogens have been shown to inhibit dopamine actions, improve neuronal regeneration, and overall, have a protective role in the pathology of schizophrenia. The adjunctive estrogen therapy for men is currently under debate. Antipsychotic medication is known to influence the hypothalamo-hypophyseal - gonadal axis by inducing variable degrees of hyperprolactinemia. Several studies have found that some of the atypical antipsychotics lower cortisol levels in patients and also in healthy controls...
October 2015: Journal of Medicine and Life
https://www.readbyqxmd.com/read/26587235/management-of-a-microprolactinoma-with-aripiprazole-in-a-woman-with-cabergoline-induced-mania
#14
Lisa Burback
UNLABELLED: A previously healthy 32-year-old woman developed cyclical mood swings after being prescribed cabergoline for a pituitary microprolactinoma. These mood swings persisted for over 2 years, at which point she developed an acute manic episode with psychotic features and was admitted to a psychiatry unit. Cabergoline was discontinued and replaced with aripiprazole 10 mg/day. Her manic episode quickly resolved, and she was discharged within 6 days of admission. The aripiprazole suppressed her prolactin levels for over 18 months of follow-up, even after the dose was lowered to 2 mg/day...
2015: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/26508971/one-year-follow-up-of-serum-prolactin-level-in-schizophrenia-patients-treated-with-blonanserin-a-case-series
#15
Sakae Takahashi, Masahiro Suzuki, Makoto Uchiyama
In our previous study, a prolactin elevation was more frequently in risperidone than in blonanserin; however, it was more often in blonanserin than in olanzapine. Therefore, while a rate of PRL rising is low to moderate, hyperprolactinemia is a considerable adverse effect in the blonanserin treatment. In this study, to examine detailed characteristics of hyperprolactinemia of blonanserin, we analyzed the prolactin data in six schizophrenic patients who were switched to blonanserin from other antipsychotics and followed for one year...
October 2015: Psychiatry Investigation
https://www.readbyqxmd.com/read/26448615/adjunctive-aripiprazole-treatment-for-risperidone-induced-hyperprolactinemia-an-8-week-randomized-open-label-comparative-clinical-trial
#16
RANDOMIZED CONTROLLED TRIAL
Jingyuan Zhao, Xueqin Song, Xiaoqing Ai, Xiaojing Gu, Guangbiao Huang, Xue Li, Lijuan Pang, Minli Ding, Shuang Ding, Luxian Lv
OBJECTIVE: The present study aimed to evaluate the efficacy and safety of adjunctive aripiprazole treatment in schizophrenia patients with risperidone-induced hyperprolactinemia. METHODS: One hundred and thirteen patients who were receiving a stable dose of risperidone were randomly assigned to either adjunctive aripiprazole treatment (10 mg/day) (aripiprazole group) or no additional treatment (control group) at a 1:1 ratio for 8 weeks. Schizophrenia symptoms were measured using the Positive and Negative Syndrome Scale (PANSS)...
2015: PloS One
https://www.readbyqxmd.com/read/25981348/adjunctive-aripiprazole-in-the-treatment-of-risperidone-induced-hyperprolactinemia-a-randomized-double-blind-placebo-controlled-dose-response-study
#17
RANDOMIZED CONTROLLED TRIAL
Jing-Xu Chen, Yun-Ai Su, Qing-Tao Bian, Li-He Wei, Rong-Zhen Zhang, Yan-Hong Liu, Christoph Correll, Jair C Soares, Fu-De Yang, Shao-Li Wang, Xiang-Yang Zhang
Hyperprolactinemia is an unwanted adverse effect associated with several antipsychotics. The addition of partial dopamine receptor agonist aripiprazole may attenuate antipsychotic-induced hyperprolactinemia effectively. However, the ideal dosing regimen for this purpose is unknown. We aimed to evaluate the dose effects of adjunctive treatment with aripiprazole on prolactin levels and hyperprolactinemia in schizophrenia patients. Stable subjects 18-45 years old with schizophrenia and hyperprolactinemia (i.e...
August 2015: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/25784810/adjunctive-treatment-with-aripiprazole-for-risperidone-induced-hyperprolactinemia
#18
Fatemeh Ranjbar, Homayoun Sadeghi-Bazargani, Parisa Niari Khams, Asghar Arfaie, Azim Salari, Mostafa Farahbakhsh
BACKGROUND: Antipsychotics have been used for more than 50 years in the treatment of schizophrenia and many other psychiatric disorders. Prolactin levels usually increase in patients treated with risperidone. Aripiprazole, which has a unique effect as an antipsychotic, is a D2 receptor partial agonist. It is an atypical antipsychotic with limited extrapyramidal symptoms. Since it acts as an antagonist in hyperdopaminergic conditions and as an agonist in hypodopaminergic conditions, it does not have adverse effects on serum prolactin levels...
2015: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/25772527/clinical-management-of-antipsychotic-induced-hyperprolactinemia
#19
Choochart Wong-Anuchit
PURPOSE: This article describes the physiology and mechanisms of prolactin and the assessment and clinical management strategies of antipsychotic-induced hyperprolactinemia. CONCLUSIONS: Hyperprolactinemia is a disorder of the hypothalamic-pituitary axis which can be caused by several mechanisms. Typical antipsychotic agents are more likely to cause hyperprolactinemia than atypical antipsychotic agents, with the exception of amisulpride, paliperidone, and risperidone...
April 2016: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/25759585/aripiprazole-for-the-management-of-schizophrenia-in-the-japanese-population-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Taro Kishi, Yuki Matsuda, Shinji Matsunaga, Nakao Iwata
BACKGROUND: We conducted a systematic review and meta-analysis of randomized controlled trials comparing aripiprazole with pooled antipsychotics in Japanese patients with schizophrenia. METHODS: We performed a literature search of data published in PubMed(®), the Cochrane Library database, the Japan Medical Abstracts Society, and PsycINFO(®) up to January 5, 2014. The odds ratio (OR), number-needed-to-harm (NNH), and standardized mean difference (SMD) based on a random effects model were calculated...
2015: Neuropsychiatric Disease and Treatment
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