keyword
MENU ▼
Read by QxMD icon Read
search

niclosamide

keyword
https://www.readbyqxmd.com/read/29770666/-molluscicidal-effect-and-mechanism-of-action-of-niclosamidate-against-oncomelania-hupensis
#1
Luo Bing-Rong, Yao Jun-Min, Wang Wei-Si, Li Shi-Zhu, Yang Jing, Chen Shao-Rong, Luo Jia-Jun, Liu Yu-Hua, Duan Li-Ping
OBJECTIVE: To evaluate the molluscicidal effect of niclosamidate against Oncomelania hupensis in laboratory and explore its mechanism by determining the enzyme activities of six important enzymes in snail soft tissues. METHODS: O. hupensis snails were treated with niclosamidate at the concentration of 1.25 mg/L for 24 h and the snail soft tissues were separated and prepared for analysis. The enzyme activities of NOS, AChE, SDH, LDH, ACP and AKP were determined by ultraviolet spectrophotometry...
February 10, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29736201/niclosamide-ethanolamine-improves-diabetes-and-diabetic-kidney-disease-in-mice
#2
Pengxun Han, Mumin Shao, Lan Guo, Wenjing Wang, Gaofeng Song, Xuewen Yu, Chunlei Zhang, Na Ge, Tiegang Yi, Shunmin Li, Heng Du, Huili Sun
Diabetes and its renal complications are major medical challenges worldwide. There are no effective drugs currently available for treating diabetes and diabetic kidney disease (DKD), especially in type 1 diabetes (T1D). Evidence has suggested that niclosamide ethanolamine salt (NEN) could improve diabetic symptoms in mice of type 2 diabetes (T2D). However, its role in T1D and DKD has not been studied to date. Here we report that NEN could protect against diabetes in streptozotocin (STZ) induced T1D mice. It increased serum insulin levels, corrected the unbalanced ratio of α-cells to β-cells, and induced islet morphologic changes under diabetic conditions...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29733962/extracellular-atp-drives-breast-cancer-cell-migration-and-metastasis-via-s100a4-production-by-cancer-cells-and-fibroblasts
#3
Ying Liu, Yue-Hang Geng, Hui Yang, Han Yang, Yan-Ting Zhou, Hong-Quan Zhang, Xin-Xia Tian, Wei-Gang Fang
Our previous work has demonstrated that extracellular ATP is an important pro-invasive factor, and in this study, we tapped into a possible mechanism involved. We discovered that ATP could upregulate both the intracellular expression and secretion of S100A4 in breast cancer cells and fibroblasts. Apart from stimulating breast cancer cell motility via intracellular S100A4, ATP enhanced the ability of breast cancer cells to transform fibroblasts into cancer-associated fibroblast (CAF)-like cells, which in turn secreted S100A4 to further promote cancer cell motility...
May 4, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29728271/corrigendum-to-preparation-characterization-and-cytotoxicity-studies-of-niclosamide-loaded-mesoporous-drug-delivery-systems-int-j-pharm-528-2017-202-214
#4
Vishwas Pardhi, Rahul B Chavan, Rajesh Thipparaboina, Sowjanya Thatikonda, V G M Naidu, Nalini R Shastri
No abstract text is available yet for this article.
May 1, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29721216/correction-niclosamide-and-its-analogs-are-potent-inhibitors-of-wnt-%C3%AE-catenin-mtor-and-stat3-signaling-in-ovarian-cancer
#5
Rebecca C Arend, Angelina I Londoño-Joshi, Abhishek Gangrade, Ashwini A Katre, Chandrika Kurpad, Yonghe Li, Rajeev S Samant, Pui-Kai Li, Charles N Landen, Eddy S Yang, Bertha Hidalgo, Ronald D Alvarez, John Michael Straughn, Andres Forero, Donald J Buchsbaum
[This corrects the article DOI: 10.18632/oncotarget.13466.].
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29663901/barriers-to-participation-in-a-community-based-program-to-control-transmission-of-taenia-solium-in-peru
#6
Michelle Beam, Angela Spencer, Lauralee Fernandez, Ruth Atto, Claudio Muro, Percy Vilchez, Ricardo Gamboa, Sandra Olaya, Viterbo Ayvar, Armando E Gonzalez, Hector H Garcia, Seth E O'Neal, For The Cysticercosis Working Group In Peru
Infection of the brain with Taenia solium larvae (neurocysticercosis) is a leading cause of preventable epilepsy worldwide. Effective and sustainable strategies to control parasite transmission in rural endemic communities are needed to prevent the disease. Surveillance and targeted intervention around infected pigs (ring control strategy) have been shown to be effective when carried out by research teams. However, this strategy has not been implemented or tested as a community-based program. In this small trial in northern Peru, eight villages were randomly assigned to community-led surveillance and treatment (five villages, 997 residents) or control (three villages, 1,192 residents)...
April 16, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29651297/niclosamide-blocks-rice-leaf-blight-by-inhibiting-biofilm-formation-of-xanthomonas-oryzae
#7
Sunil Kumar Sahu, Ping Zheng, Nan Yao
Rice ( Oryza sativa ) is the leading source of nutrition for more than half of the world's population, and by far it is the most important commercial food crop. But, its growth and production are significantly hampered by the bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo) which causes leaf blight disease. Earlier studies have reported the antibacterial ability of FDA-approved niclosamide drug against Xoo. However, the underlying mechanism by which niclosamide blocks the growth of Xoo remained elusive...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29603892/niclosamide-a-drug-with-many-re-purposes
#8
Hachemi Kadri, Olivia A Lambourne, Youcef Mehellou
Niclosamide is an anthelmintic drug that has mainly been used for over 50 years to treat tapeworm infections. However, with the increase in drug repurposing initiatives, niclosamide has emerged as a true hit in many screens against various diseases. Indeed, from being an anthelmintic drug, it has now shown potential in treating Parkinson's disease, diabetes, viral and microbial infections as well as various cancers. Such diverse pharmacological activities are a result of niclosamide's ability to uncouple mitochondrial phosphorylation and modulate a selection of signaling pathways, such as Wnt/β-catenin, mTOR and JAK/STAT3, which are implicated many diseases...
March 30, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29568198/comparative-molluscicidal-and-schistosomicidal-potentiality-of-two-solanum-species-and-its-isolated-glycoalkaloids
#9
Muhammad A Alsherbiny, Shymaa A El Badawy, Hesham Elbedewy, Shahira M Ezzat, Fatma S Elsakhawy, Mostafa A Abdel-Kawy
Schistosomiasis is the most noteworthy parasitic disease after malaria. Furthermore, the significant activity of the genus Solanum against Schistosoma worms and its intermediate host snails reinforced the study of Solanum seaforthianum Andr. (SS) and Solanum macrocarpon L. (SM) for their molluscicidal and schistosomicidal potentiality. In this study, different extracts, fractions and isolated compounds of both Solanum species are evaluated for the molluscicidal and schistosomicidal potentialities. The niclosamide was used as positive molluscicide control against Biomphalaria alexandrina snails...
January 2018: Pharmacognosy Research
https://www.readbyqxmd.com/read/29556331/niclosamide-sensitizes-nasopharyngeal-carcinoma-to-radiation-by-downregulating-ku70-80-expression
#10
Jingjing Li, Haiwen Li, Dechao Zhan, Mei Xiang, Jun Yang, Yufang Zuo, Yin Yu, Hechao Zhou, Danxian Jiang, Haiqing Luo, Zihong Chen, Zhonghua Yu, Zumin Xu
The aim of the present study was to investigate whether niclosamide could sensitize the nasopharyngeal carcinoma cells to radiation and further explore the underlying mechanisms. CCK-8 assay was used to determine the effect of niclosamide on the proliferation of NPC cells. Colony formation assay was used to evaluate the radiosensitizing effect of niclosamide on NPC cells. Flow cytometry analysis was used to determine the apoptosis of NPC cells induced by niclosamide. Immunofluorescent staining was used to detect the formation of γ-H2AX foci and the localization of Ku70/80 proteins in NPC cells...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29545902/jak2-stat3-pathway-as-a-therapeutic-target-in-ovarian-cancers
#11
Tomoyuki Yoshikawa, Morikazu Miyamoto, Tadashi Aoyama, Hiroaki Soyama, Tomoko Goto, Junko Hirata, Ayako Suzuki, Isao Nagaoka, Hitoshi Tsuda, Kenichi Furuya, Masashi Takano
The activation of JAK2/STAT3 pathway has been reported to have critical roles in several solid tumors. The present study aimed to evaluate the correlation between JAK2/STAT3 activation and clinicopathological parameters in ovarian cancer types. Tissue microarrays made from the patients treated at the National Defense Medical College Hospital between 1984 and 2008 were evaluated using immunohistochemical (IHC) stainings. Medical charts of these patients including IHC results were retrospectively analyzed, and prognostic factors for progression-free survival and overall survival were evaluated...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29544454/phase-ii-trial-to-investigate-the-safety-and-efficacy-of-orally-applied-niclosamide-in-patients-with-metachronous-or-sychronous-metastases-of-a-colorectal-cancer-progressing-after-therapy-the-nikolo-trial
#12
Susen Burock, Severin Daum, Ulrich Keilholz, Konrad Neumann, Wolfgang Walther, Ulrike Stein
No abstract text is available yet for this article.
March 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29529569/adsorption-and-transformation-of-the-anthelmintic-drug-niclosamide-by-manganese-oxide
#13
Thai Ha Tran, Jérôme Labanowski, Hervé Gallard
The manganese oxide birnessite adsorbed and catalyzed the transformation of the anthelminthic drug niclosamide (NIS) into 2-chloro-4-nitroaniline (CNA) and 5-chlorosalicylic acid (CSA) at acidic pH. The adsorption of NIS was fitted using a linear isotherm for all conditions and reaction times. Linear adsorption constant Kd was 103 000 L kg-1 at pH 5.0. The rate of transformation was first order with respect to both MnO2 and NIS. At pH 5.0, the second order rate constant was 3.3 (±0.3) × 10-1  M-1  s-1 ...
June 2018: Chemosphere
https://www.readbyqxmd.com/read/29528187/down-regulation-of-dishevelled-2-inhibits-cell-proliferation-and-invasion-in-hepatoblastoma
#14
Siqi Huang, Jing Chen, Ruicheng Tian, Jing Wang, Chenjie Xie, Hongxiang Gao, Yuhua Shan, Jie Hong, Zhen Zhang, Min Xu, Song Gu
BACKGROUND: Hepatoblastoma (HB) is the most common liver cancer found in early childhood. These patients suffer poor outcomes and need novel therapies. An abnormal activation of Wnt signaling is the hallmark of HB tumorigenesis, and its pathway is a potential candidate for a pharmacological intervention. PROCEDURE: Tissue samples of patients with HB were collected for RNA-seq, quantitative real-time PCR, and immunohistochemistry to identify if disheveled-2 (Dvl-2) was a target gene...
March 12, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29508571/-molluscicidal-effect-of-suspension-concentrate-of-niclosamide-ethanolamine-salt
#15
Y Yi, C Shun-Xiang, H E Zheng-Wen, L I Bo, W You-Bin, T U Zhen, X U Zhao-Gang, H E Hui, X Bo
Objective To evaluate the molluscicidal effect of suspension concentrate of niclosamide ethanolamine salt (SCNE) against Oncomelania hupensis snails in laboratory and field. Methods The experiment of SCNE against the snails by using the immersing and spraying methods was performed in laboratory and field, with control groups of wettable powder of niclosamide ethanolamine salt (WPN). Results In the laboratory, LC50(s) of SCNE for 24, 48 h and 72 h by using the immersion method were 0.092 6, 0.062 9 mg/L and 0...
July 27, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29487357/repurposing-the-anthelmintic-drug-niclosamide-to-combat-helicobacter-pylori
#16
Nagendran Tharmalingam, Jenna Port, Dawilmer Castillo, Eleftherios Mylonakis
There is an urgent need to discover novel antimicrobial therapies. Drug repurposing can reduce the time and cost risk associated with drug development. We report the inhibitory effects of anthelmintic drugs (niclosamide, oxyclozanide, closantel, rafoxanide) against Helicobacter pylori strain 60190 and pursued further characterization of niclosamide against H. pylori. The MIC of niclosamide against H. pylori was 0.25 μg/mL. Niclosamide was stable in acidic pH and demonstrated partial synergy with metronidazole and proton pump inhibitors, such as omeprazole and pantoprazole...
February 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29486057/niclosamide-inhibits-vascular-smooth-muscle-cell-proliferation-and-migration-and-attenuates-neointimal-hyperplasia-in-injured-rat-carotid-arteries
#17
Xiao-Lin Xiao, Nan Hu, Xin-Zi Zhang, Man Jiang, Chang Chen, Rui Ma, Zhen-Gang Ma, Jin-Lai Gao, Xiu-Chen Xuan, Zhi-Jie Sun, De-Li Dong
BACKGROUND AND PURPOSE: The anti-helminthic drug niclosamide regulates multiple cellular signals including STAT3, AMP-activated protein kinase (AMPK), Akt, Wnt/β-catenin and mitochondrial uncoupling which are involved in neointimal hyperplasia. Here we have examined the effects of niclosamide on vascular smooth muscle cell proliferation, migration and neointimal hyperplasia and assessed the potential mechanisms. EXPERIMENTAL APPROACH: Cell migration was measured by using wound-induced migration assay and Boyden chamber assay...
May 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29480568/niclosamide-an-oral-antihelmintic-drug-exhibits-antimetastatic-activity-in-hepatocellular-carcinoma-cells-through-downregulating-twist-mediated-cd10-expression
#18
Ming-Hsien Chien, Yung-Chuan Ho, Shun-Fa Yang, Yi-Chieh Yang, Szu-Yu Lai, Wan-Shen Chen, Ming-Jenn Chen, Chao-Bin Yeh
Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world, especially, in eastern Asia, and its prognosis is poor once metastasis occurs. Niclosamide, a US Food and Drug Administration-approved antihelmintic drug, was shown to inhibit the growth of various cancers including HCC, but the effect of niclosamide on cell motility and the underlying mechanism have not yet been completely defined. The present study demonstrated that niclosamide, at 0-40 nM, concentration-dependently inhibited wound closure and the migratory/invasive capacities of human Huh7 and SK-Hep-1 HCC cells without exhibiting cytotoxicity...
June 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29469461/-effects-and-cost-of-four-formulations-of-niclosamide-ethanolamine-salt-in-oncomelania-hupensis-snail-control-in-field
#19
He Liang-Cai, Wang Jia-Song, Rong Xian-Bing, Yuan Mei-Zhi, Li Tian-Yan, Liao Qiang, Tan Xian-Yu, Hu Hehua, Tian Ke-Qing, Liu Xiong, Zhang Xia, Su Wen, Cui Cai-Xia, Tian Rong
OBJECTIVE: To investigate the effects and cost of four formulations of niclosamide ethanolamine salt in Oncomelania hupensis snail control in the field in marshland and lake regions, so as to provide the evidence for drawing up the plan of molluscicide using in schistosomiasis endemic areas. METHODS: One drainage channel and one channel without water in the same area with snails in Jiangling County, Jingzhou City were selected as the research fields. The drainage channel was divided into 9 sections, except one section as a blank control group where the natural death rate of snails was observed only, and the remaining 8 sections were taken as the observation groups, where different dosages of 4% niclosamide ethanolamine salt powder, 5% niclosamide ethanolamine salt granules, 25% niclosamide ethanolamine salt suspending agent, 26% metaldehyde and niclosamide ethanolamine salt suspending agent, and 50% niclosamide ethanolamine salt wettable powder were used respectively...
December 26, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29440715/effect-of-mitochondrial-uncouplers-niclosamide-ethanolamine-nen-and-oxyclozanide-on-hepatic-metastasis-of-colon-cancer
#20
Amer Alasadi, Michael Chen, G V T Swapna, Hanlin Tao, Jingjing Guo, Juan Collantes, Noor Fadhil, Gaetano T Montelione, Shengkan Jin
Metabolism of cancer cells is characterized by aerobic glycolysis, or the Warburg effect. Aerobic glycolysis reduces pyruvate flux into mitochondria, preventing a complete oxidation of glucose and shunting glucose to anabolic pathways essential for cell proliferation. Here we tested a new strategy, mitochondrial uncoupling, for its potential of antagonizing the anabolic effect of aerobic glycolysis and for its potential anticancer activities. Mitochondrial uncoupling is a process that facilitates proton influx across the mitochondrial inner membrane without generating ATP, stimulating a futile cycle of acetyl- CoA oxidation...
February 13, 2018: Cell Death & Disease
keyword
keyword
111778
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"