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https://www.readbyqxmd.com/read/29684903/repurposing-itraconazole-to-the-benefit-of-skin-cancer-treatment-a-combined-azole-ddab-nanoencapsulation-strategy
#1
C Carbone, C Martins-Gomes, V Pepe, A M Silva, T Musumeci, G Puglisi, P M Furneri, E B Souto
In this work, we aimed at developing an improved topical SLN formulation combining itraconazole delivery with a coating layer of didodecyldimethylammonium bromide, thus repurposing the drug effectiveness by synergistic skin anticancer effectiveness. In order to obtain a stable SLN formulation with small homogeneously dispersed particles, a deep formulative study was developed screening three different solid lipids (Suppocire NB, Cetyl Palmitate and Dynasan 114) for the SLN preparation by the phase inversion temperature...
April 17, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29684233/secondary-prevention-strategies-for-nonmelanoma-skin-cancer
#2
REVIEW
Adriana T Lopez, Richard D Carvajal, Larisa Geskin
Skin cancer is the most commonly diagnosed cancer in the United States and has become a major public health problem that continues to grow. Despite numerous initiatives and increased public awareness of the dangers of skin cancer, the incidence of skin cancer continues to rise worldwide. This highlights the need for a critical review of existing skin cancer prevention strategies as a means to determine where targeted efforts may improve patient outcomes. In this article, we review the published literature and evaluate secondary prevention strategies for nonmelanoma skin cancer...
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29683380/diverse-roles-of-rad18-and-y-family-dna-polymerases-in-tumorigenesis
#3
Yang Yang, Yanzhe Gao, Anastasia Zlatanou, Satoshi Tateishi, Vyacheslav Yurchenko, Igor B Rogozin, Cyrus Vaziri
Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin ligase RAD18 and its downstream effectors, the 'Y-family' Trans-Lesion Synthesis (TLS) DNA polymerases, confer DNA damage tolerance at the expense of DNA replication fidelity. Thus, RAD18 and TLS polymerases are attractive candidate mediators of mutagenesis and carcinogenesis. The skin cancer-propensity disorder xeroderma pigmentosum-variant (XPV) is caused by defects in the Y-family DNA polymerase Pol eta (Polη). However it is unknown whether TLS dysfunction contributes more generally to other human cancers...
April 23, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29683290/pain-perception-during-photodynamic-therapy-why-is-daylight-pdt-with-mal-almost-pain-free
#4
Rolf-Markus Szeimies
Photodynamic Therapy (PDT) with methyl aminolevulinate (MAL) is an established and efficacious method for the treatment of non-melanoma skin cancer. However, treatment of especially larger areas often leads to pain, stinging and burning sensation during illumination. The use of daylight (DL) during MAL incubation was investigated in clinical trials and compared to conventional illumination with red LEDs. All clinical trials on MAL DL-PDT show it to be considerably and statistically significantly less associated with pain than conventional PDT while being as efficacious...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29683285/long-term-efficacy-data-for-daylight-pdt
#5
Maria C Fargnoli
INTRODUCTION: Conventional photodynamic therapy (c-PDT) is an established successful treatment for non-melanoma skin cancers (NMSC). Daylight PDT (DL-PDT) was introduced to overcome the main inconveniencies associated with c-PDT such as pain during illumination and long clinic visits. DL-PDT was shown to have similar short-term efficacy to c-PDT for the treatment of mild/moderate AKs but it is associated with better tolerability. Since AKs tend to regress and reoccur over time, data on long-term efficacy of DL-PDT become crucial...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29681629/incidence-of-complications-in-dermatological-surgery-of-melanoma-and-non-melanoma-skin-cancer-in-patients-with-multiple-comorbidity-and-or-antiplatelet-anticoagulants-five-year-experience-in-our-hospital
#6
Lilia Arguello-Guerra, Estefanía Vargas-Chandomid, Jose Manuel Díaz-González, Silvia Méndez-Flores, Ana Ruelas-Villavicencio, Judith Domínguez-Cherit
Introduction: Surgery is performed more frequently now at days, due to the increasing incidence of melanoma and no-melanoma skin cancer. There are different opinions among dermatologic surgeons between to continue or discontinue antithrombotic therapy prior to the procedure, which increases the risk of thromboembolic events. Prophylaxis with oral antibiotics in the postsurgical period is controversial. Objective: To report the safety of surgery without suspending antithrombotic therapy and without oral antibiotic prophylaxis in dermatology surgery of patients with multiple comorbidities and polypharmacy...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29680587/azathioprine-to-mycophenolate-mofetil-transition-and-risk-of-squamous-cell-carcinoma-after-lung-transplantation
#7
Martin Vos, Elsemieke I Plasmeijer, Barbara C van Bemmel, Wim van der Bij, Nina S Klaver, Michiel E Erasmus, Geertruida H de Bock, Erik A M Verschuuren, Emőke Rácz
BACKGROUND: Chronic immunosuppression after solid-organ transplantation is a risk factor for cutaneous squamous cell carcinoma (cSCC) development. Certain immunosuppressant drugs, namely azathioprine and calcineurin inhibitors, increase this risk more than others. We investigated incidence of cSCC in a Dutch lung transplant recipient (LTR) cohort and analyzed associated risk factors. METHODS: All LTRs with post-transplant survival of >30 days were included. Data included indication for lung transplantation and duration of medication use...
March 19, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29679901/replacement-of-arg-with-nle-and-modified-d-phe-in-the-core-sequence-of-mshs-ac-his-d-phe-arg-trp-nh-2-leads-to-hmc1r-selectivity-and-pigmentation
#8
Saghar Mowlazadeh Haghighi, Yang Zhou, Jixun Dai, Jonathon R Sawyer, Victor J Hruby, Minying Cai
Melanoma skin cancer is the fastest growing cancer in the US [1]. A great need exists for improved formulations and mechanisms to prevent and protect human skin from cancers and other skin damage caused by sunlight exposure. Current efforts to prevent UV damage to human skin, which in many cases leads to melanoma and other skin cancers. The primordial melanocortin-1 receptor (MC1R) is involved in regulating skin pigmentation and hair color, which is a natural prevention from UV damage. The endogenous melanocortin agonists induce pigmentation and share a core pharmacophore sequence "His-Phe-Arg-Trp", and it was found that substitution of the Phe by D-Phe results in increasing melanocortin receptor potency...
April 11, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29679610/mutated-mitf-e87r-in-melanoma-enhances-tumor-progression-via-s100a4
#9
Alice Nordlinger, Shani Dror, Abdel Elkahloun, Justine Del Rio, Elisa Stubbs, Tami Golan, Hagar Malcov, Todd D Pricket, Julia C Cronin, Shivang Parikh, Sapir Labes, Laetitia Thomas, Gal Yankovitz, Yuval Tabach, Carmit Levy, Yardena Samuels, Mehdi Khaled
Melanoma, a melanocyte origin neoplasm, is the most lethal type of skin cancer and incidence is increasing. Several familial and somatic mutations have been identified in the gene encoding the melanocyte lineage master regulator, microphthalmia-associated transcription factor (MITF); however, the neoplastic mechanisms of these mutant MITF variants are mostly unknown. Here, by performing unbiased analysis of the transcriptomes in cells expressing mutant MITF, we identified calcium-binding protein S100A4, as a downstream target of MITF-E87R...
April 18, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29679494/risk-of-sun-induced-skin-cancers-in-patients-with-alopecia-areata-alopecia-totalis-and-alopecia-universalis
#10
Rosalynn R Z Conic, Rose Miller, Melissa Piliang, Wilma Bergfeld, Natasha Atanaskova Mesinkovska
Alopecia areata (AA) is an autoimmune non-scarring hair loss characterized by round patches on the scalp and body. It can progress to alopecia totalis (AT) where there is total loss of scalp hair and alopecia universalis (AU) in where hair loss encompasses the entire body. The pathophysiologic mechanism is unclear, but is thought to be due to peribulbar T-cell inflammation which results in premature induction of anagen follicles to catagen and telogen, without causing destruction of the hair follicle. This article is protected by copyright...
April 21, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29674370/effect-of-a-single-prophylactic-preoperative-oral-antibiotic-dose-on-surgical-site-infection-following-complex-dermatological-procedures-on-the-nose-and-ear-a-prospective-randomised-controlled-double-blinded-trial
#11
Helena Rosengren, Clare F Heal, Petra G Buttner
OBJECTIVES: There is limited published research studying the effect of antibiotic prophylaxis on surgical site infection (SSI) in dermatological surgery, and there is no consensus for its use in higher-risk cases. The objective of this study was to determine the effectiveness of a single oral preoperative 2 g dose of cephalexin in preventing SSI following flap and graft dermatological closures on the nose and ear. DESIGN: Prospective double-blinded, randomised, placebo-controlled trial testing for difference in infection rates...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29672736/all-pins-are-not-created-equal-communicating-skin-cancer-visually-on-pinterest
#12
Sung-Eun Park, Lu Tang, Bijie Bie, Degui Zhi
We analyze the visual characteristics of skin cancer pins, including use of human image, use of fear-invoking image, pin composition, color, and text legibility. We also explore how these visual characteristics as well as information richness predict Pinterest users' participative engagement. A combination of descriptive and predictive content analysis of 708 pins is conducted. The demographic characteristics of human models are consistent with epidemiology data. Text legibility in bodycopy is low. Information richness is a significant predictor of number of repins in all pins except pins on melanoma with human models...
April 17, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29667448/influencing-health-decision-making-a-study-of-colour-and-message-framing
#13
Raymond P Voss, Ryan Corser, Michael McCormick, John D Jasper
OBJECTIVE: Previous research has provided evidence that colour associations and frame can influence behavioural intentions to engage in vaccination behaviours. In this study, the extension of these effects to sunscreen application behaviours was investigated. Additional colours and the manner in which colour primes were employed were also explored. DESIGN: Two hundred and eighty-six college students were primed with either short wavelength colours (blue/purple) or long wavelength colours (red/orange) as part of goal framed sunscreen information pamphlets...
April 18, 2018: Psychology & Health
https://www.readbyqxmd.com/read/29667105/the-role-of-autophagy-in-the-resistance-to-braf-inhibition-in-braf-mutated-melanoma
#14
Xiao Liu, Jinfeng Wu, Haihong Qin, Jinhua Xu
Malignant melanoma is the most aggressive and notorious skin cancer, and metastatic disease is associated with very poor long-term survival outcomes. Although metastatic melanoma patients with oncogenic mutations in the BRAF gene initially respond well to the treatment with specific BRAF inhibitors, most of them will eventually develop resistance to this targeted therapy. As a highly conserved catabolic process, autophagy is responsible for the maintenance of cellular homeostasis and cell survival, and is involved in multiple diseases, including cancer...
April 17, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29666044/capturing-ultraviolet-radiation-exposure-and-physical-activity-feasibility-study-and-comparison-between-self-reports-mobile-apps-dosimeters-and-accelerometers
#15
Elke Hacker, Caitlin Horsham, Martin Allen, Andrea Nathan, John Lowe, Monika Janda
BACKGROUND: Skin cancer is the most prevalent cancer in Australia. Skin cancer prevention programs aim to reduce sun exposure and increase sun protection behaviors. Effectiveness is usually assessed through self-report. OBJECTIVE: It was the aim of this study to test the acceptance and validity of a newly developed ultraviolet radiation (UVR) exposure app, designed to reduce the data collection burden to research participants. Physical activity data was collected because a strong focus on sun avoidance may result in unhealthy reductions in physical activity...
April 17, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29664771/effects-of-1-540-nm-fractional-nonablative-erbium-and-2-940-nm-fractional-ablative-erbium-on-p53-epidermal-expression-after-3-months-a-split-face-interventional-study
#16
Juliano Borges, Luciana Araújo, Rodrigo P B de Oliveira, Monica Manela-Azulay
BACKGROUND: Expression of p53 by keratinocytes may be important in the pathogenesis of skin cancer induced by ultraviolet light. OBJECTIVE: We used side-by-side nonablative and ablative erbium fractional laser resurfacing to assess the effects on expression of p53 by facial keratinocytes. METHODS: Ten female patients (age range, 50-63 years) with Fitzpatrick skin Types I-IV and clinical signs of photoaging underwent erbium fractional laser resurfacing (nonablative, 1,540-nm; ablative, 2,940-nm) on opposite sides of the face...
April 16, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29663897/computational-study-of-imidazolylporphyrin-derivatives-as-a-radiopharmaceutical-ligand-kit-for-melanoma
#17
Fransiska Kurniawan, Rahmana E Kartasasmita, Naoki Yoshioka, Abdul Mutalib, Daryono H Tjahjono
Melanoma is the most aggressive type of skin cancer. Metastatic melanoma is extremely difficult to treat with current therapy methods such as surgery. On the other hand, it is a good opportunity to develop a radiopharmaceutical using a radionuclide such as technetium (Tc) for diagnostic and rhenium (Re) for therapeutic purposes. T3,4BCPP has been be used as a radioimaging agent for melanoma cancers experimentally. The aim of the present research was to design new imidazolylporphyrin derivatives with better selectivity and higher affinity than those of T3,4BCPP by molecular modeling...
April 16, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29661854/targeting-toll-like-receptors-in-cancer-prevention
#18
EDITORIAL
Karen S Sfanos
There is a pressing need for the development of new prevention strategies for the most common worldwide malignancy, nonmelanoma skin cancer (NMSC), as sun protection efforts have not proven to be completely effective. Interestingly, despite the known circumstance that individuals undergoing chronic immunosuppression are at a substantially increased risk for developing NMSC, in this issue of Cancer Prevention Research , Blohm-Mangone and colleagues provide new evidence that topical application of the Toll-like receptor 4 (TLR4) antagonist resatorvid may be efficacious as a chemopreventive agent in NMSC specifically via blocking UV-induced inflammatory signaling...
April 16, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29661336/cutaneous-head-and-neck-malignancies-in-the-elderly
#19
REVIEW
Brian B Hughley, Cecelia E Schmalbach
Cutaneous malignancy of the head and neck affects a large proportion of elderly patients. The severity ranges from small, easily treatable lesions to large, invasive, potentially metastatic tumors. Surgical treatment is the primary treatment of most skin cancers; however, geriatric patients are more likely to have multiple comorbidities that increase the risk of surgery. Multiple treatment modalities exist, including surgical, radiation, and medical therapy. Recommendations and treatment options for basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma, and melanoma are outlined and reviewed...
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29660479/nanodiamond-applications-in-skin-preparations
#20
REVIEW
Roshanak Namdar, Shohreh Nafisi
The biocompatibility and nontoxicity of nanodiamonds (NDs) in combination with their excellent physical performance have rendered them attractive candidates for biomedical applications. NDs have great potential in drug nanoformulations because of their small size compared with other carbon nanomaterials. They are nontoxic with excellent adsorption properties and can be formulated into skin care products. Even though NDs have shown encouraging potential in skin preparations, only a few studies have reviewed their application in topical drug delivery systems...
April 13, 2018: Drug Discovery Today
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