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https://www.readbyqxmd.com/read/28340496/recent-developments-in-nanomedicine-for-melanoma-treatment
#1
REVIEW
Jian-Qin Tang, Xiao-Yang Hou, Chun-Sheng Yang, Ya-Xi Li, Yong Xin, Wen-Wen Guo, Zhi-Ping Wei, Yan-Qun Liu, Guan Jiang
Melanoma is a most aggressive skin cancer with limited therapeutic options and its incidence is increasing rapidly in recent years. The discovery and application of new targeted therapy agents have shown significant benefits. However, adverse side-effects and resistance to chemotherapy remain formidable challenges in the clinical treatment of malignant melanoma. Nanotherapeutics offers an important prospect of overcoming these drawbacks. The anti-tumoral applications of nanomedicine are varied, including those in chemotherapy, RNA interference, photothermal therapy, and photodynamic therapy...
March 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28336806/fluorouracil-enhances-photodynamic-therapy-of-squamous-cell-carcinoma-via-a-p53-independent-mechanism-that-increases-protoporphyrin-ix-levels-and-tumor-cell-death
#2
Sanjay Anand, Kishore R Rollakanti, Niokelta Brankov, Douglas E Brash, Tayyaba Hasan, Edward V Maytin
Photodynamic therapy (PDT), using 5-aminolevulinic acid (ALA) to drive synthesis of protoporphryin IX (PpIX) is a promising, scar-free alternative to surgery for skin cancers, including squamous cell carcinoma (SCC) and SCC precursors called actinic keratoses (AK). In the United States, PDT is only FDA approved for treatment of AK; this narrow range of indications could be broadened if PDT efficacy were improved. Toward that goal, we developed a mechanism-based combination approach using 5-fluorouracil (5-FU) as a neoadjuvant for ALA-based PDT...
March 23, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28336503/tweet-for-behavior-change-using-social-media-for-the-dissemination-of-public-health-messages
#3
Aisling Gough, Ruth F Hunter, Oluwaseun Ajao, Anna Jurek, Gary McKeown, Jun Hong, Eimear Barrett, Marbeth Ferguson, Gerry McElwee, Miriam McCarthy, Frank Kee
BACKGROUND: Social media public health campaigns have the advantage of tailored messaging at low cost and large reach, but little is known about what would determine their feasibility as tools for inducing attitude and behavior change. OBJECTIVE: The aim of this study was to test the feasibility of designing, implementing, and evaluating a social media-enabled intervention for skin cancer prevention. METHODS: A quasi-experimental feasibility study used social media (Twitter) to disseminate different message "frames" related to care in the sun and cancer prevention...
March 23, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28336336/sunbed-use-among-64-000-danish-students-and-the-associations-with-demographic-factors-health-related-behaviours-and-appearance-related-factors
#4
Maria Kristine Hagelskær Meyer, Brian Køster, Lise Juul, Janne Schurmann Tolstrup, Pernille Bendtsen, Peter Dalum, Anne Sofie Plum Christensen
Sunbed use is associated with an increased risk for skin cancer and is particularly dangerous for younger persons. The objective of this study was to assess how demographic factors, health-related behaviours and appearance-related factors are associated with sunbed use. Cross-sectional data from the Danish National Youth Study collected by the National Institute of Public Health during 2014 was used. A total of 64,382 students aged 15-25years were included in the present study. Multilevel logistic regression analyses were used to determine associations...
March 20, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28332195/skin-cancer-history-sun-related-attitudes-behaviour-and-sunburn-among-renal-transplant-recipients-versus-general-population
#5
Vivian Ka Ying Leung, Suzanne Jane Dobbinson, David Josef Goodman, John Kanellis, Alvin Heong Chong
BACKGROUND/OBJECTIVES: Renal transplant recipients (RTR) have both an excessive skin cancer incidence and a high mortality rate. In Australia RTR receive extensive public education on skin cancer and many undergo further education pre/post-transplant. This study examines whether RTR have sufficiently rigorous sun protection behaviour compared with the general population. METHODS: Altogether 179 RTR from two large Melbourne hospitals involving skin clinic teams in patient care were recruited to undergo cross-sectional telephone interviews...
March 23, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28330805/photodynamic-therapeutic-efficacy-of-symmetrical-diiodinated-squaraine-in-in-vivo-skin-cancer-models
#6
M S Soumya, D Devi Gayathri, K M Shafeekh, Suresh Das, Annie Abraham
BACKGROUND: Photodynamic therapy (PDT) has clinical approval for use as a minimally invasive therapeutic procedure that is able to exert selective cytotoxic activity toward malignant cells. The dye selected for our study, symmetrical diiodinated squaraine, is one of the newly developed photosensitizers. The study is designed to determine the efficacy of PDT mediated by symmetrical diiodinated squaraine in skin tumor induced Swiss albino mice. METHODS: Skin tumor was induced in mice with dimethyl benzanthracene (DMBA) and croton oil...
March 19, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28330284/in-vitro-evaluation-of-anti-proliferative-anti-inflammatory-and-pro-apoptotic-activities-of-the-methanolic-extracts-of-andrographis-nallamalayana-ellis-on-a375-and-b16f10-melanoma-cell-lines
#7
Guroji Purushotham, Yerukala Padma, Yusuf Nabiha, R R Venkata Raju
Natural plant products have been widely used in controlling cancer with fewer or no side effects and the use of plant extracts as complementary to synthetic medicine is gaining increased popularity. Members of Andrographis plants possess important medicinal properties. In the present study, anti-cancerous properties of Andrographis nallamalayana (AN) were tested on A375 and B16F10 skin melanoma cancer cell lines. The leaf extracts of AN significantly reduced the cell viability and cell survival of skin cancer cell lines, achieved by MTT assay and clonogenic assays, respectively...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329671/trends-of-skin-cancer-incidence-following-transplantation-in-the-united-states
#8
Sarah T Arron
BackgroundSkin cancer is the most common malignancy occurring after organ transplantation. Although previous research has reported an increased risk of skin cancer in solid organ transplant recipients (OTR), no study has estimated the post-transplant population-based incidence in the US. The objective of this study is to determine the incidence and evaluate the predictors of post-transplant skin cancer, including squamous cell carcinoma (SCC), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTR receiving a primary transplant in 2003 or 2008...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329669/sun-protection-behavior-and-sunburns-among-arizona-adults
#9
Stephanie M Koch, Robin B Harris, Elizabeth T Jacobs, Kacey C Ernst, Leslie K Dennis
ObjectiveTo examine the prevalence of sun protection behaviors and sunburn history among adults in a region of the United States with high ultraviolet radiation exposure.Design and SettingData on self-reported sun protection and sunburns were obtained using supplemental questions added to the 2013 Arizona Behavioral Risk Factor Surveillance System survey. 3,370 Arizona adults over the age of 18 years completed questions about use sunscreen and protective clothing and reported sunburns within past 12 months...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329666/risks-of-different-skin-tumor-combinations-after-a-first-melanoma-squamous-cell-carcinoma-and-basal-cell-carcinoma-in-dutch-population-based-cohorts-1989-2009
#10
R J T Van der Leest, L M Hollestein, L Liu, T Nijsten, E De Vries
The aim of this study was to calculate risks of different type of subsequent skin cancers.All melanoma and squamous cell carcinoma (SCC) patients included in the national Netherlands Cancer Registry (NCR) and all basal cell carcinoma (BCC) patients included in the regional Eindhoven Cancer Registry (ECR) between 1989 and 2009 were followed until diagnosis of a subsequent different skin cancer (melanoma, SCC or BCC), date of death or end of study. Cumulative risk, Standardized Incidence Ratio (SIR) and Absolute Excess Risk (AER) of subsequent skin cancers were calculated...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329662/the-preneoplastic-genome-transcriptomic-drivers-of-squamous-cell-carcinoma-development
#11
Kenneth Y Tsai
Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in the U.S. annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). In order to identify potential targets for molecularly targeted chemoprevention, we performed integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar UV- driven Hairless mouse model. We performed RNA-seq and microRNA-seq on samples from both patients undergoing Mohs surgery and the mouse model...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329660/predictors-of-tanning-dependence-in-white-non-hispanic-females-and-males
#12
Brenda Cartmel, Susan T Mayne, Allen E Bale, Joel Gelernter, Andrew DeWan, David J Leffell, Sherry Pagoto, Peter Spain, Leah M Ferrucci
Growing evidence suggests some individuals may exhibit dependence to ultraviolet light, a known carcinogen; however, few studies have investigated predictors of tanning dependence (TD).A sub-set of early-onset basal cell carcinoma case-control study participants completed an online survey. The modified-Cut down, Annoyed, Guilty, Eye-opener (mCAGE) and a questionnaire based on the addiction criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (mDSM-IV-TR) were used to classify participants having'Symptoms of TD' if they met criteria for TD on both questionnaires, 'Tendency for TD' if met criteria on only one questionnaire, or 'Not TD'...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329657/perceptions-of-indoor-vs-outdoor-tanning-risks-among-melanoma-patients-who-have-a-history-of-indoor-uv-tanning-an-international-internet-survey
#13
Jennifer Nergard, Chauncey Caldwell, Morgan Barr, Robert P Dellavalle, James A Solomon
IntroductionA new U.S. FDA regulation categorizes tanning beds as category II¹, and similar global regulatory action require informing users of the "risk of skin cancer" as methods to reverse the growing trend of indoor tanning. However, little is known from the patient's perspective on whether or not knowledge of risk of cancer is a deterrent to indoor tanning. Also, there is conflicting literature on the relationship between frequency of indoor tanning, age of onset and characteristics of patients' melanoma diagnoses...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329655/new-keratinocyte-carcinomas-worsen-skin-related-quality-of-life
#14
Julia A Siegel, Mary-Margaret Chren, Martin A Weinstock
Keratinocyte carcinoma (KC) is the most common malignancy in the U.S. Because KC affects many people but has a low mortality rate, it is important to consider the impact of KC on skin-related quality of life (QoL). We aimed to determine if KCs, actinic keratoses (AKs), and several demographic and health-related factors were associated with skin- related QoL in those at high risk for KC. We used data from a double-blind, placebo- controlled trial in which 932 veterans with multiple prior KCs were randomized to apply topical 5-fluorouracil (5-FU) or vehicle control cream to the face/ears...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329648/hormonal-and-reproductive-factors-and-incidence-of-basal-cell-carcinoma-in-a-population-based-cohort
#15
Catherine M Olsen, Nirmala Pandeya, Bridie S Thompson, Jean Claude Dusingize, Padmini Subramaniam, Christina M Nagle, Adele C Green, Rachel E Neale, Penny M Webb, David C Whitman
Estrogens have photosensitizing properties, but few prospective studies have examined the relationship between hormonal and reproductive factors and incidence of basal cell carcinoma (BCC) in women. Previous findings have been inconsistent, particularly in relation to parity and use of oral contraceptives (OCs) and menopausal hormone therapy (MHT). Given the heterogeneity in the literature, we sought to examine the association between hormonal and reproductive factors and BCC risk in a cohort of women (n=23,879) enrolled in the QSkin Study in 2011...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329646/gaps-in-the-understanding-and-treatment-of-skin-cancer-in-people-of-color
#16
Ajay Kailas
People of color are at significantly higher risk in mortality from skin cancers, such as melanoma, than Caucasians. Around 4,500,000 people of color are affected by skin cancer The five-year survival rates from melanoma are 81.1% for Hispanics, 80.2% for Asians, 72.2% for African- Americans, and 89.6% for Caucasians. For this reason, it is important to ensure the scientific literature reflects the most up to date recommendations and treatment for blacks regarding skin cancer. Therefore the authors conducted a "gap analysis" on the current treatment of skin cancer in people of color...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329644/family-history-of-cancer-in-relation-to-the-risk-of-keratinocyte-carcinoma-plus-another-type-of-cancer-a-case-control-study
#17
J Small, C Flanagan, K Armeson, D Perry, R Marchell, B Thiers, A J Alberg
BackgroundA personal history of keratinocyte carcinoma (KC) is associated with increased risk for other malignancies. To assess the role of inherited cancer predisposition we investigated if family history (FH) of skin cancer plus noncutaneous malignancy is associated with the risk of KC plus another type of cancer.MethodsThis clinic-based case-control study of non-Hispanic Caucasians had three age- and gender-matched groups: KC plus another cancer (n=49), KC only (n=50), and cancer-free controls (n=50). Patients were interviewed to assess FH in first-degree relatives of "skin cancer" and "cancer other than skin cancer...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329635/compliance-with-indoor-tanning-laws-for-minors-among-salons-and-business-in-the-united-states
#18
Courtney Choy, Brenda Cartmel, Rachel Clare, Leah M Ferrucci
Indoor tanning is an established risk factor for skin cancer, yet indoor tanning is quite common among adolescents. Laws exists in some states to limit access to indoor tanning by minors, but there is limited research on industry compliance with these laws.We conducted a telephone survey with a random sample of businesses (n=412) offering indoor tanning in the 14 states with indoor tanning bans for minors as of May 2015. Female research assistants posing as minors conducted telephone interviews with employees using a standardized script...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329632/cigarette-smoking-and-the-risks-of-incident-basal-cell-carcinoma-and-squamous-cell-carcinoma-in-a-large-population-based-cohort-study
#19
Jean Claude Dusingize, Catherine M Olsen, Nirmala Pandeya, Bridie Thompson, Rachel E Neale, Padmini Subramaniam, David C Whiteman, Adele C Green
Tobacco smoking is a strong risk factor for cancer, but associations with basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) of the skin have been inconsistent. We prospectively investigated the associations between cigarette smoking and 3-year incidence of first primary BCC or SCC in the QSkin cohort (n=43765). Smoking history was self-reported at baseline; newly diagnosed and surgically treated BCCs and SCCs were ascertained through linkage to the national health insurance scheme and verified by histopathology reports...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329631/the-burden-of-keratinocyte-cancer-occurrence-multiplicity-and-predicting-risk
#20
David C Whiteman, Nirmala Pandeya, Bridie Thompson, Padmini Subramaniam, Jean Claude Dusingize, Rachel E Neale, Adele C Green, Catherine M Olsen
The costs of diagnosing and treating basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) are the highest of all cancers in Australia. However, information regarding incidence, multiplicity and risk are scarce as keratinocyte cancers (KCs) are not captured by most registries. To address these gaps, we initiated the QSKIN Study in 2010 recruiting 43,794 Queensland residents from a population register (participation 24%). Participants self-completed a baseline survey recording information on residential history, sun exposure, phenotype and medical and family history...
September 15, 2016: Dermatology Online Journal
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