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Osteoporosis management review

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https://www.readbyqxmd.com/read/29763969/hormone-replacement-therapy-for-women-previously-treated-for-endometrial-cancer
#1
REVIEW
Katharine A Edey, Stuart Rundle, Martha Hickey
BACKGROUND: Endometrial cancer is the sixth most common cancer in women worldwide and most commonly occurs after the menopause (75%) (globocan.iarc.fr). About 319,000 new cases were diagnosed worldwide in 2012. Endometrial cancer is commonly considered as a potentially 'curable cancer,' as approximately 75% of cases are diagnosed before disease has spread outside the uterus (FIGO (International Federation of Gynecology and Obstetrics) stage I). The overall five-year survival for all stages is about 86%, and, if the cancer is confined to the uterus, the five-year survival rate may increase to 97%...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29753705/spinal-cord-injury-how-could-acupuncture-help
#2
REVIEW
Qianqian Fan, Omer Cavus, Lize Xiong, Yun Xia
Spinal cord injury (SCI) is one of the most common causes of death and disability worldwide, and it can result in both permanent disability and serial complications in patients. Research shows that patients with SCI complications are often interested in acupuncture for symptomatic relief. Therefore, the issue of physicians advising their patients regarding the use of acupuncture to alleviate SCI complications becomes pertinent. We review and summarize two types of relevant publications: (1) literature concerning acupuncture for SCI and its complications and (2) underlying mechanisms of acupuncture therapy for SCI...
May 10, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29748558/the-gastroenterologist-s-guide-to-management-of-the-post-liver-transplant-patient
#3
REVIEW
David M Chascsa, Hugo E Vargas
The management of the post-liver transplant patient is complex and involves a large interdisciplinary team. After referral to a transplant center, evaluation and listing, and eventual transplantation, the patient is cared for closely by the transplant center. Once deemed ready for discharge, the patient returns to the primary care provider for ongoing management of the various issues that increase in incidence post transplant such as osteoporosis, cardiovascular, and renal diseases, as well as metabolic syndrome...
May 11, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29745791/prevention-and-management-of-osteoporosis-and-osteoporotic-fractures-in-persons-with-a-spinal-cord-injury-or-disorder-a-systematic-scoping-review
#4
Nour Zleik, Frances Weaver, Robert L Harmon, Brian Le, Reshmitha Radhakrishnan, Wanda D Jirau-Rosaly, B Catharine Craven, Mattie Raiford, Jennifer N Hill, Bella Etingen, Marylou Guihan, Michael H Heggeness, Cara Ray, Laura Carbone
OBJECTIVES: The primary objective was to review the literature regarding methodologies to assess fracture risk, to prevent and treat osteoporosis and to manage osteoporotic fractures in SCI/D. STUDY DESIGN: Scoping review. Settings/Participants: Human adult subjects with a SCI/D. OUTCOME MEASURES: Strategies to identify persons with SCI/D at risk for osteoporotic fractures, nonpharmacological and pharmacological therapies for osteoporosis and management of appendicular fractures...
May 10, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29736627/expressed-information-needs-of-patients-with-osteoporosis-and-or-fragility-fractures-a-systematic-review
#5
REVIEW
Grace Raybould, Opeyemi Babatunde, Amy L Evans, Joanne L Jordan, Zoe Paskins
This systematic review identified patients have unmet information needs about the nature of osteoporosis, medication, self-management and follow-up. Clinician knowledge and attitudes appear to be of key importance in determining whether these needs are met. Unmet information needs appear to have psychosocial consequences and result in poor treatment adherence. PURPOSE: Patient education is an integral component of the management of osteoporosis, yet patients are dissatisfied with the information they receive and see this as an area of research priority...
May 8, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29727238/treatment-of-osteoporosis-whom-how-and-for-how-long
#6
Anastasia D Dede, Margaret Callan
Identification of patients at risk for fragility fractures is the first important step in the management of osteoporosis. Bisphosphonates have been the mainstay of treatment for decades, whereas denosumab and selective oestrogen receptor modulators are other available licensed antiresorptive drugs. Currently teriparatide is the only approved anabolic agent in Europe, while abaloparatide and romosozumab are awaiting approval and might be available in the near future. For bisphosphonates, current guidance suggests an initial treatment course of 3-5 years and more prolonged treatment should be pursued in patients with higher fracture risk...
May 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29714695/the-role-of-dental-care-providers-in-the-management-of-patients-prescribed-bisphosphonates-brief-clinical-guidance
#7
Hassan H Abed, Elham N Al-Sahafi
Dental care providers are likely to see patients who take bisphosphonates for various medical conditions, including osteoporosis, bony metastatic tumors, multiple myeloma, breast cancer, and prostate cancer. Bisphosphonates accumulate in areas of high bone turnover, leading to suppression of bone turnover and the aging of keratocytes. These adverse effects predispose the maxillary and mandibular bone to development of medication-related osteonecrosis of the jaw (MRONJ), specifically among oncology patients treated with intravenous bisphosphonate therapy...
May 2018: General Dentistry
https://www.readbyqxmd.com/read/29713422/pulmonary-embolism-from-cement-augmentation-of-the-vertebral-body
#8
REVIEW
Jose Manuel Fernando Ignacio, Katrina Hannah Dizon Ignacio
Pulmonary cement embolism (PCE) can follow cement augmentation procedures for spine fractures due to osteoporosis, traumatic injuries, and painful metastatic lesions. PCE is underreported and it is likely that many cases remain undiagnosed. Risk factors for PCE have been identified, which can help alert clinicians to patients likely to develop the condition, and there are recommended techniques to reduce its incidence. Most patients with PCE are asymptomatic or only develop transient symptoms, although a few may exhibit florid cardiorespiratory manifestations which can ultimately be fatal...
April 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29703028/osteoporosis-and-fracture-after-gastrectomy-for-stomach-cancer-a-nationwide-claims-study
#9
Gi Hyeon Seo, Hae Yeon Kang, Eun Kyung Choe
This study was planned to evaluate the incidence and risk factors of osteoporosis and fracture after gastrectomy for stomach cancer using a nationwide claims database in South Korea.Data from 41,512 patients (50-79 years) who underwent gastrectomy for stomach cancer from 2008 to 2010 with at least 5 years of follow-up were obtained from the Health Insurance Review and Assessment Service database. Patients diagnosed with osteoporosis and prescribed bisphosphonate or raloxifene or who experienced osteoporotic fractures after gastrectomy were operationally defined as osteoporosis...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29698784/machine-learning-to-predict-the-occurrence-of-bisphosphonate-related-osteonecrosis-of-the-jaw-associated-with-dental-extraction-a-preliminary-report
#10
Dong Wook Kim, Hwiyoung Kim, Woong Nam, Hyung Jun Kim, In-Ho Cha
INTRODUCTION: The aim of this study was to build and validate five types of machine learning models that can predict the occurrence of BRONJ associated with dental extraction in patients taking bisphosphonates for the management of osteoporosis. PATIENTS & METHODS: A retrospective review of the medical records was conducted to obtain cases and controls for the study. Total 125 patients consisting of 41 cases and 84 controls were selected for the study. Five machine learning prediction algorithms including multivariable logistic regression model, decision tree, support vector machine, artificial neural network, and random forest were implemented...
April 23, 2018: Bone
https://www.readbyqxmd.com/read/29680239/protein-and-peptides-for-elderly-health
#11
Nan Shang, Chalamaiah Meram, Nandika Bandara, Jianping Wu
The world is aging rapidly; thus, the management of elderly health at an advanced age poses a new research challenge. The elderly is vulnerable to not only malnutrition but also hypofunction of all organs and a variety of chronic diseases such as sarcopenia, osteoporosis, gastrointestinal dysfunction, and mental problems. As the major macronutrient, food protein plays an important role in elderly health and well-being. In this chapter, the function of protein and peptide in elderly health as well as their effects on preventing aging-related disease is reviewed...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29676289/natural-history-and-outcome-of-inflammatory-bowel-diseases-in-children-in-saudi-arabia-a-single-center-experience
#12
Khalid M Alreheili, Khalid A Alsaleem, Ali I Almehaidib
Background/Aim: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder which includes ulcerative colitis (UC), Crohn's disease (CD), and indeterminate colitis (IC). The natural history of pediatric IBDs is poorly understood and generally unpredictable. We aim to study the natural history of IBD in Saudi children including the extraintestinal manifestations, changes in diagnosis, disease behavior, medical management, and surgical outcome. Patients and Methods: A retrospective review of all the charts of children less than 14 years of age who were diagnosed as IBD and followed up in King Faisal Specialist Hospital and Research Center (KFSH and RC) from January 2001 to December 2011 was performed...
April 18, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29675745/a-proposal-for-an-atypical-femur-fracture-treatment-and-prevention-clinical-practice-guideline
#13
REVIEW
R Dell, D Greene
The prevention as well as the treatment of atypical femur fractures (AFFs) remains controversial but there have been many clinical recommendations suggested. We have summarized these recommendations as well as expanded upon them in this paper. INTRODUCTION: The purpose of the paper was to develop a clinical practice guideline that both treats AFF and decreases the risk of AFF in patients requiring antiresorptive medications. Examples of these medications include bisphosphonates and denosumab for the treatment of osteoporosis...
April 19, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29621030/long-term-treatment-strategies-for-postmenopausal-osteoporosis
#14
Felicia Cosman
PURPOSE OF REVIEW: Osteoporosis guidelines do not usually provide specific recommendations regarding what medication is most appropriate for individual patients. Generic oral bisphosphonates are often considered first-line treatment for osteoporosis, but treatment duration is limited, based on potential long-term safety concerns, and there is no consensus about what to do after 5 years. There are no recommendations concerning long-term management of osteoporosis over 30 or more years of postmenopausal life...
April 4, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29619093/aromatase-inhibitors-are-associated-with-a-higher-fracture-risk-than-tamoxifen-a-systematic-review-and-meta-analysis
#15
REVIEW
Olivia L Tseng, John J Spinelli, Carolyn C Gotay, Wan Y Ho, Mary L McBride, Martin G Dawes
Background: In this paper, our aim was to systematically evaluate published evidence of bone fracture risk associated with tamoxifen and aromatase inhibitors in women aged 65 and under, and diagnosed with nonmetastatic breast cancer. Methods: We comprehensively searched MEDLINE, EMBASE and CINAHL databases from January 1997 through May 2015, and reference lists of the selected articles to identify English-language randomized controlled trials and cohort studies of fracture risk...
April 2018: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/29607594/management-of-the-female-athlete-triad
#16
Sayaka Nose-Ogura, Miyuki Harada, Osamu Hiraike, Yutaka Osuga, Tomoyuki Fujii
The female athlete triad (FAT) is defined by the American College of Sports Medicine (ACSM) as low energy availability (low EA), functional hypothalamic amenorrhoea and osteoporosis. In low EA, lutein dysfunction first develops, followed by anovulation and, subsequently, oligomenorrhea, leading to amenorrhea. Moreover, low estradiol concentrations due to amenorrhea decrease bone mineral density (BMD). In athletes with one of the factors of FAT, the risk of a stress fracture is 2.4-4.9 times higher and may increase the risk of fracture throughout the lifespan...
April 2, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29602163/portuguese-recommendations-for-the-prevention-diagnosis-and-management-of-primary-osteoporosis-2018-update
#17
A M Rodrigues, H Canhão, A Marques, C Ambrósio, J Borges, P Coelho, L Costa, S Fernandes, I Gonçalves, M Gonçalves, M Guerra, M L Marques, S Pimenta, P Pinto, G Sequeira, E Simões, L Teixeira, C Vaz, E Vieira-Sousa, R Vieira, F Alvarenga, F Araújo, A Barcelos, F Barcelos, R Barros, M Bernardes, J Canas da Silva, A Cordeiro, M Costa, L Cunha-Miranda, M Cruz, A C Duarte, C Duarte, A Faustino, G Figueiredo, J E Fonseca, C Furtado, J Gomes, C Lopes, A F Mourão, M Oliveira, F M Pimentel-Santos, A Ribeiro, T Sampaio da Nóvoa, M Santiago, C Silva, A Silva-Dinis, S Sousa, J Tavares-Costa, G Terroso, A Vilar, J C Branco, V Tavares, J C Romeu, Jap da Silva
BACKGROUND: Advances in osteoporosis (OP)case definition, treatment options, optimal therapy duration and pharmacoeconomic evidence in the national context motivated the Portuguese Society of Rheumatology (SPR) to update the Portuguese recommendations for the diagnosis and management of osteoporosis published in 2007. METHODS: SPR bone diseases' working group organized meetings involving 55 participants (rheumatologists, rheumatology fellows and one OP specialist nurse) to debate and develop the document...
January 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29572126/bone-health-during-endocrine-therapy-for-cancer
#18
REVIEW
Tilman D Rachner, Robert Coleman, Peyman Hadji, Lorenz C Hofbauer
Preservation of bone health remains a long-term clinical challenge in patients with breast and prostate cancer. Osteoporosis, defined by a loss of bone mass and microarchitecture, often results in fragility fractures that are typically associated with a high socioeconomic burden. Endocrine therapy, a mainstay treatment in the management of patients with hormone-sensitive breast and prostate cancer in the adjuvant setting, commonly exerts adverse effects on the musculoskeletal system and is associated with an increased risk of osteoporosis and fractures...
March 20, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29565945/is-vitamin-d-supplementation-effective-for-low-back-pain-a-systematic-review-and-meta-analysis
#19
Joshua R Zadro, Debra Shirley, Manuela Ferreira, Ana Paula Carvalho Silva, Sarah E Lamb, Cyrus Cooper, Paulo H Ferreira
BACKGROUND: Low back pain (LBP) is the leading cause of years lived with disability worldwide. Current intervention strategies are failing to reduce the enormous global burden of LBP and are prompting researchers to investigate alternative management strategies, such as vitamin D supplementation. Vitamin D supplementation appears to down regulate pro-inflammatory cytokines which lead to pain and up regulate anti-inflammatory cytokines that reduce inflammation. These mechanisms might explain the increasing interest in the use of vitamin D supplementation for LBP...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29555309/fracture-liaison-services-improve-outcomes-of-patients-with-osteoporosis-related-fractures-a-systematic-literature-review-and-meta-analysis
#20
Chih-Hsing Wu, Shih-Te Tu, Yin-Fan Chang, Ding-Cheng Chan, Jui-Teng Chien, Chih-Hsueh Lin, Sonal Singh, Manikanta Dasari, Jung-Fu Chen, Keh-Sung Tsai
OBJECTIVES: This systematic review and meta-analysis evaluated the outcomes of patients with osteoporosis-related fractures managed through fracture liaison services (FLS) programs. METHODS: Medline, PubMed, EMBASE, and the Cochrane Library were searched (January 2000-February 2017 inclusive) using the keywords 'osteoporosis', 'fractures', 'liaison', and 'service' to identify randomised controlled trials and observational studies of patients aged ≥50years with osteoporosis-related fractures in hospital, clinic, community, or home-based settings who were managed using FLS...
March 16, 2018: Bone
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