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https://www.readbyqxmd.com/read/28918337/ecotoxicological-and-microbiological-assessment-of-sewage-sludge-associated-with-sugarcane-bagasse
#1
Lais Roberta Deroldo Sommaggio, Dânia Elisa Christofoletti Mazzeo, Débora de Andrade E Silva Sant' Anna, Carlos Emílio Levy, Maria Aparecida Marin-Morales
Sewage sludge (SS) obtained after sewage treatment process may contain several toxic substances. Bioremediation can decrease the toxicity of the sludge, mainly when it is associated with stimulant agents, such as sugarcane bagasse (B). Samples of pure SS (SSP); SS+B; SS+Soil; and SS+B+Soil were bioremediated for 1, 3, and 6 months (T1, T2, and T3, respectively). After each period, the cytotoxic, genotoxic, and mutagenic potentials of the solid samples and their respective aqueous extracts (aqueous eluate and percolate water) were evaluated by the Allium cepa test...
September 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28915453/soil-organic-matter-in-podzol-horizons-of-the-amazon-region-humification-recalcitrance-and-dating
#2
Amanda M Tadini, Gustavo Nicolodelli, Giorgio S Senesi, Débora A Ishida, Célia R Montes, Yves Lucas, Stéphane Mounier, Francisco E G Guimarães, Débora M B P Milori
Characteristics of soil organic matter (SOM) are important, especially in the Amazon region, which represents one of the world's most relevant carbon reservoirs. In this work, the concentrations of carbon and differences in its composition (humification indexes) were evaluated and compared for several horizons (0 to 390cm) of three typical Amazonian podzol profiles. Fluorescence spectroscopy was used to investigate the humic acid (HA) fractions of SOM isolated from the different samples. Simple and labile carbon structures appeared to be accumulated in surface horizons, while more complex humified compounds were leached and accumulated in intermediate and deeper Bh horizons...
September 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28914298/folic-acid-on-iron-oxide-nanoparticles-platform-with-high-potential-for-simultaneous-targeting-mri-detection-and-hyperthermia-treatment-of-lymph-node-metastases-of-prostate-cancer
#3
Debora Bonvin, Jessica A M Bastiaansen, Matthias Stuber, Heinrich Hofmann, Marijana Mionić Ebersold
The overexpression of the folate receptor in most cancers has been widely exploited to specifically deliver folic acid (FA) coupled nanomedicines to tumors. However, complex coupling chemistry is often used to bind FA to the nanoparticles. Furthermore, very little has been reported for the targeting of nanomedicines to lymph node metastases (LNMs) of prostate cancer. We here report the simple and aqueous coating of iron oxide nanoparticles (IONPs) with FA for theranostics of LNMs of prostate cancer. FA was directly bound to the IONPs' surface without the use of any linker, simultaneously playing the role of the coating molecule and targeting agent...
September 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28913976/hplc-hrms-for-the-characterization-of-transformation-products-of-ionic-liquids
#4
Debora Fabbri, Paola Calza, Giorgio Noè, Valentina Santoro, Claudio Medana
RATIONALE: Ionic liquids (ILs) are a subject of active research in the field of alternative solvents. We studied the behaviour of a piperidine IL, 1-butyl-1-methylpiperidinium tetrafluoroborate (BMPA), through the elucidation of its transformation products (TPs) in water. METHODS: The transformation pathways of BMPA were investigated using high-performance liquid chromatography (HPLC) combined with a hybrid LTQ-Orbitrap instrument on the basis of mass defect filtering...
September 14, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28911954/erratum-of-hearing-thresholds-at-high-frequency-in-patients-with-cystic-fibrosis-a-systematic-review
#5
Debora T M Caumo, Lúcia B Geyer, Adriane R Teixeira, Sérgio S M Barreto
No abstract text is available yet for this article.
September 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28906456/effects-of-%C3%AE-glucans-ingestion-on-alveolar-bone-loss-intestinal-morphology-systemic-inflammatory-profile-and-pancreatic-%C3%AE-cell-function-in-rats-with-periodontitis-and-diabetes
#6
Viviam de O Silva, Raquel V Lobato, Eric F Andrade, Débora R Orlando, Bruno D B Borges, Márcio G Zangeronimo, Raimundo V de Sousa, Luciano J Pereira
This study aimed to evaluate the effects of β-glucan ingestion (Saccharomyces cerevisiae) on the plasmatic levels of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10), alveolar bone loss, and pancreatic β-cell function (HOMA-BF) in diabetic rats with periodontal disease (PD). Besides, intestinal morphology was determined by the villus/crypt ratio. A total of 48 Wistar rats weighing 203 ± 18 g were used. Diabetes was induced by the intraperitoneal injection of streptozotocin (80 mg/kg) and periodontal inflammation, by ligature...
September 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28904971/cognitive-or-cognitive-motor-executive-function-tasks-evaluating-verbal-fluency-measures-in-people-with-parkinson-s-disease
#7
Alessandra Ferreira Barbosa, Mariana Callil Voos, Janini Chen, Debora Cristina Valente Francato, Carolina de Oliveira Souza, Egberto Reis Barbosa, Hsin Fen Chien, Letícia Lessa Mansur
INTRODUCTION: Executive function deficits are observed in people with Parkinson's disease (PD) from early stages and have great impact on daily living activities. Verbal fluency and oral diadochokinesia involve phonarticulatory coordination, response inhibition, and phonological processing and may also be affected in people with PD. This study aimed to describe the performance of PD patients and an age- and education-matched control group on executive function, verbal fluency, and oral diadochokinesia tests and to investigate possible relationships between them...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28904555/acyclic-sesquiterpenes-from-the-fruit-pericarp-of-sapindus-saponaria-induce-ultrastructural-alterations-and-cell-death-in-leishmania-amazonensis
#8
Amanda Louzano Moreira, Débora Botura Scariot, Bruna Luíza Pelegrini, Greisiele Lorena Pessini, Tânia Ueda-Nakamura, Celso Vataru Nakamura, Izabel Cristina Piloto Ferreira
Previous studies reported antiprotozoal activities of Sapindus saponaria L. The aim of this work was the evaluation of antileishmanial activity and mechanism of action of extract and fractions of S. saponaria L. Hydroethanolic extract (EHA) obtained from fruit pericarps was fractionated using solid-phase extraction in a reversed phase, resulting in fractions enriched with saponins (SAP fraction) and acyclic sesquiterpene oligoglycosides (OGSA fraction). The activities of EHA, SAP, and OGSA were evaluated by antiproliferative assays with promastigote and intracellular amastigote forms...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28902413/frequent-genes-in-rare-diseases-panel-based-next-generation-sequencing-to-disclose-causal-mutations-in-hereditary-neuropathies
#9
Maike F Dohrn, Nicola Glöckle, Lejla Mulahasanovic, Corina Heller, Julia Mohr, Christine Bauer, Erik Riesch, Andrea Becker, Florian Battke, Konstanze Hörtnagel, Thorsten Hornemann, Saranya Suriyanarayanan, Markus Blankenburg, Jörg B Schulz, Kristl G Claeys, Burkhard Gess, Istvan Katona, Andreas Ferbert, Debora Vittore, Alexander Grimm, Stefan Wolking, Ludger Schöls, Holger Lerche, G Christoph Korenke, Dirk Fischer, Bertold Schrank, Urania Kotzaeridou, Gerhard Kurlemann, Bianca Dräger, Anja Schirmacher, Peter Young, Beate Schlotter-Weigel, Saskia Biskup
Hereditary neuropathies comprise a wide variety of chronic diseases associated to more than 80 genes identified to date. We herein examined 612 index patients with either a Charcot-Marie-Tooth phenotype, hereditary sensory neuropathy, familial amyloid neuropathy, or small fiber neuropathy using a customized multigene panel based on the next generation sequencing (NGS) technique. In 121 cases (19.8%), we identified at least one putative pathogenic mutation. Out of these, 54.4% showed an autosomal dominant, 33...
September 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28902258/phlebotomines-in-an-area-endemic-for-american-cutaneous-leishmaniasis-in-northeastern-coast-of-brazil
#10
Ana Patricia Oliveira da Silva, Débora Elienai de Oliveira Miranda, Marcos Antônio Bezerra Santos, Neurisvan Ramos Guerra, Silvia Rafaelli Marques, Leucio Câmara Alves, Rafael Antonio Nascimento Ramos, Gílcia Aparecida de Carvalho
Phlebotomines have worldwide distribution with many species present in Brazil, including the northeastern region, where the fauna is very diverse. The aim of this study was to identify the sandfly fauna in an area endemic for American cutaneous leishmaniasis (ACL) in the state of Pernambuco. Sandflies were caught on three consecutive nights every month from October 2015 to September 2016, from 5 pm to 5 am, using seven light traps of Centers for Disease Control (CDC) type. Females were identified and used for molecular Leishmania detection...
August 24, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28902245/tooth-resorptions-are-not-hereditary
#11
Alberto Consolaro, Débora de Almeida Bianco
Root resorptions caused by orthodontic movement are not supported by consistent scientific evidence that correlate them with heredity, individual predisposition and genetic or familial susceptibility. Current studies are undermined by methodological and interpretative errors, especially regarding the diagnosis and measurements of root resorption from orthopantomographs and cephalograms. Samples are heterogeneous insofar as they comprise different clinical operators, varied types of planning, and in insufficient number, in view of the prevalence of tooth resorptions in the population...
July 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28901279/role-of-physical-exercise-and-omega-3-fatty-acids-on-depressive-illness-in-the-elderly
#12
Stefano Farioli-Vecchioli, Stefano Sacchetti, Vittoria Nicolis di Robilant, Debora Cutuli
BACKGROUND: In adulthood, depression is the most common type of mental illness and will be the second leading cause of disease by 2020. Major depression dramatically affects the function of the central nervous system and degrades life quality, especially during aging. Several mechanisms underlie the pathophysiology of depressive illness, given it has a multifactorial etiology. Human and animal studies have demonstrated that depression is mainly associated with imbalances in neurotransmitters and neurotrophins, hypothalamic-pituitary-adrenal axis alterations, brain volume changes, neurogenesis dysfunction, and dysregulation of inflammatory pathways...
September 11, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28899903/socs3-expression-in-sf1-cells-regulates-adrenal-differentiation-and-exercise-performance
#13
João Ab Pedroso, Pedro Omori Ribeiro de Mendonça, Marco As Fortes, Igor Tomaz, Vitor L Pecorali, Thais B Auricino, Ismael C Costa, Leandro B Lima, Isadora C Furigo, Debora N Bueno, Angela M Ramos-Lobo, Claudimara Ferini Pacicco Lotfi, Jose Donato
Many hormones/cytokines are secreted in response to exercise and cytokine signaling may play a pivotal role in the training adaptations. To investigate the importance of cytokine signaling during vertical ladder climbing, a resistance exercise model, we produced mice lacking SOCS3 protein exclusively in steroidogenic factor-1 (SF1) cells (SF1 Socs3 KO mice). SF1 expression is found in steroidogenic cells of the adrenal cortex and gonads, as well as in neurons of the ventromedial nucleus of the hypothalamus...
September 12, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28898885/pilot-neonatal-screening-program-for-central-congenital-hypothyroidism-evidence-of-significant-detection
#14
Débora Braslavsky, Maria Virginia Méndez, Laura Prieto, Ana Keselman, Rosa Enacan, Laura Gruñeiro-Papendieck, Nicolas Jullien, Alexandru Savenau, Rachel Reynaud, Thierry Brue, Ignacio Bergadá, Ana Chiesa
BACKGROUND/AIM: Congenital hypothyroidism (CH) is a heterogeneous entity. Neonatal screening programs based on thyrotropin (TSH) determination allow primary CH diagnosis but miss central CH (CCH). CCH causes morbidity, alerts to other pituitary deficiencies, and is more prevalent than previously thought. We aimed at developing a pilot neonatal screening program for CCH detection. PATIENTS AND METHODS: A prospective 2-year pilot neonatal screening study based on simultaneous dried blood specimen TSH and thyroxine (T4) measurements was implemented in term newborns aged 2-7 days...
September 12, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28898353/in-vivo-chemotherapeutic-insight-of-a-novel-isocoumarin-3-hexyl-5-7-dimethoxy-isochromen-1-one-genotoxicity-cell-death-induction-leukometry-and-phagocytic-evaluation
#15
Flávio Henrique Souza de Araújo, Débora Rojas de Figueiredo, Sarah Alves Auharek, João Renato Pesarini, Alisson Meza, Roberto da Silva Gomes, Antônio Carlos Duenhas Monreal, Andréia Conceição Milan Brochado Antoniolli-Silva, Dênis Pires de Lima, Candida Aparecida Leite Kassuya, Adilson Beatriz, Rodrigo Juliano Oliveira
Chemotherapy is one of the major approaches for the treatment of cancer. Therefore, the development of new chemotherapy drugs is an important aspect of medicinal chemistry. Chemotherapeutic agents include isocoumarins, which are privileged structures with potential antitumoral activity. Herein, a new 3-substituted isocoumarin was synthesized from 2-iodo-3,5-dimethoxy-benzoic acid and oct-1-yne in a cross-coupling Sonogashira reaction followed by a copper iodide-catalyzed intramolecular cyclization as key step using MeOH/Et3N as the solvent system...
July 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28898286/structural-investigation-of-c6-36-and-vero-cell-cultures-infected-with-a-brazilian-zika-virus
#16
Debora Ferreira Barreto-Vieira, Fernanda Cunha Jácome, Marcos Alexandre Nunes da Silva, Gabriela Cardoso Caldas, Ana Maria Bispo de Filippis, Patrícia Carvalho de Sequeira, Elen Mello de Souza, Audrien Alves Andrade, Pedro Paulo de Abreu Manso, Gisela Freitas Trindade, Sheila Maria Barbosa Lima, Ortrud Monika Barth
Zika virus (ZIKV) is a member of the flavivirus genus, and its genome is approximately 10.8 kilobases of positive-strand RNA enclosed in a capsid and surrounded by a membrane. Studies on the replication dynamics of ZIKV are scarce, which limits the development of antiviral agents and vaccines directed against ZIKV. In this study, Aedes albopictus mosquito lineage cells (C6/36 cells) and African green monkey kidney epithelial cells (Vero cells) were inoculated with a ZIKV sample isolated from a Brazilian patient, and the infection was characterized by immunofluorescence staining, phase contrast light microscopy, transmission electron microscopy and real-time RT-PCR...
2017: PloS One
https://www.readbyqxmd.com/read/28891701/sedative-effects-of-intranasal-midazolam-administration-in-wild-caught-blue-fronted-amazon-amazona-aestiva-and-orange-winged-amazon-amazona-amazonica-parrots
#17
Débora P H Schaffer, Nayone L L C de Araújo, Ana Cláudia S Raposo, Emanoel F Martins Filho, João Victor R Vieira, Arianne P Oriá
Safe and effective sedation protocols are important for chemical restraint of birds in clinical and diagnostic procedures, such as clinical evaluations, radiographic positioning, and blood collection. These protocols may reduce stress and ease the management of wild-caught birds, which are susceptible to injury or death when exposed to stressful situations. We compare the sedative effect of intranasal midazolam in wild-caught blue-fronted (Amazona aestiva) and orange-winged (Amazona amazonica) Amazon parrots...
September 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28886864/analysis-of-the-cranio-cervical-curvatures-in-subjects-with-migraine-with-and-without-neck-pain
#18
Gabriela Natália Ferracini, Thais Cristina Chaves, Fabíola Dach, Débora Bevilaqua-Grossi, César Fernández-de-Las-Peñas, José Geraldo Speciali
OBJECTIVE: To investigate the differences in head and cervical spine alignment between subjects with migraine and healthy people. DESIGN: A cross-sectional, observational study. PARTICIPANTS: Fifty subjects with migraine and 50 matched healthy controls. MAIN OUTCOMES MEASURES: The presence of neck pain and neck pain-related disability was assessed. Four angles (high cervical angle, low cervical angle, atlas plane angle and cervical lordosis Cobb angle) as well as four distances (anterior translation distance, C0 to C1 distance, C2 to C7 posterior translation and hyoid triangle) were calculated using digitalised radiographs and analysed using K-Pacs(®) software...
March 24, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28885961/effectiveness-of-ice-sheet-cooling-following-exertional-hyperthermia
#19
Cory L Butts, Debora L Spisla, J D Adams, Cody R Smith, Kathleen M Paulsen, Aaron R Caldwell, Matthew S Ganio, Brendon P McDermott
BACKGROUND: The procedure of wrapping a heat casualty in ice-water soaked bed sheets to reduce core temperature has received little investigation, despite the practice and recommendation for its use in some military settings. Thus, the purpose of this study was to investigate the cooling efficacy of ice-sheet cooling (ISC) following exertional hyperthermia. METHODS: 13 (11 males, 2 females) participants (age = 23 ± 3 years, height = 176.5 ± 10.3 cm, mass = 78...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28882961/efficacy-of-n-acetylcysteine-d-mannose-and-morinda-citrifolia-to-treat-recurrent-cystitis-in-breast-cancer-survivals
#20
Debora Marchiori, Pier Paolo Zanello
BACKGROUND/AIM: Breast cancer survivors in adjuvant therapy, frequently experience the estrogen deficiency with genitourinary symptoms mostly represented by recurrent bacterial cystitis. The objective of the present study was to evaluate the effectiveness of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract (NDM), when associated to antibiotic therapy, in reducing the persistence of recurrent cystitis in this risk population. PATIENTS AND METHODS: Sixty breast cancer survived women with recurrent cystitis were retrospectively examined...
September 2017: In Vivo
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