keyword
MENU ▼
Read by QxMD icon Read
search

Debora

keyword
https://www.readbyqxmd.com/read/28742227/melatonin-prevents-mitochondrial-dysfunctions-and-death-in-differentiated-skeletal-muscle-cells
#1
Sara Salucci, Michela Battistelli, Valentina Baldassarri, Debora Burini, Elisabetta Falcieri, Sabrina Burattini
Oxidative stress increase induces cellular damage and apoptosis activation, a mechanism believed to represent a final common pathway correlated to sarcopenia and many skeletal muscle disorders. The goal of this study is to evaluate if melatonin, a ROS scavenger molecule, is able to counteract or modulate myotube death. Here, differentiated C2C12 skeletal muscle cells have been treated with melatonin before chemicals known to induce apoptotic death and oxidative stress, and its effect has been investigated by means of morpho-functional analyses...
July 25, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28740837/histological-remission-of-autoimmune-hepatitis-after-the-addition-of-allopurinol-and-azathioprine-dose-reduction
#2
Ana Luiza Vilar Guedes, Adriana Ribas Andrade, Vinicius Santos Nunes, Fabiana Roberto Lima, Evandro Sobroza de Mello, Suzane Kioko Ono, Débora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado
The standard therapy for some autoimmune diseases consists of a combination of corticosteroids and thiopurines. In non-responders to thiopurine drugs, the measurement of the metabolites of azathioprine, 6-thioguanine, and 6-methylmercaptopurine, can be a useful tool. The measurement has been used during the treatment of inflammatory bowel diseases and, less commonly, in autoimmune hepatitis. Many patients preferentially metabolize thiopurines to 6-methylmercaptopurine (6-MMP), which is potentially hepatotoxic, instead of 6-thioguanine, the active immunosuppressive metabolite...
April 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/28739787/resistance-to-ceftazidime-avibactam-is-due-to-transposition-of-kpc-in-a-porin-deficient-strain-of-klebsiella-pneumoniae-with-increased-efflux-activity
#3
Kirk Nelson, Peera Hemarajata, Dongxu Sun, Debora Rubio-Aparicio, Ruslan Tsivkovski, Shangxin Yang, Robert Sebra, Andrew Kasarskis, Hoan Nguyen, Blake M Hanson, Shana Leopold, George Weinstock, Olga Lomovskaya, Romney M Humphries
Ceftazidime-avibactam is an antibiotic with activity against serine beta-lactamases, including KPC. Recently, reports have emerged of KPC-producing isolates resistant to this antibiotic, including a report of a wild-type KPC-3 producing sequence type 258 Klebsiella pneumoniae that was resistant to ceftazidime-avibactam. We describe a detailed analysis of this isolate, in the context of two other closely related KPC-3 producing isolates, recovered from the same patient. Both isolates encoded a non-functional OmpK35, whereas we demonstrate a novel T333N mutation in OmpK36, present in the ceftazidime-avibactam resistant isolate, reduced activity of this porin and impacted ceftazidime-avibactam susceptibility...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28738982/safe-practice-recommendations-for-the-use-of-copy-forward-with-nursing-flow-sheets-in-hospital-settings
#4
Emily S Patterson, Dawn M Sillars, Nancy Staggers, Esther Chipps, Laurie Rinehart-Thompson, Valerie Moore, Debora Simmons, Susan D Moffatt-Bruce
BACKGROUND: In early 2016 the Partnership for Health IT Patient Safety released safe practice recommendations for the use of copy-paste for electronic health record (EHR) documentation. These recommendations do not directly address nurses' use of copy-forward to document patient assessments in flow sheet software in hospital settings. Similar to clinicians' use of copy-paste and copy-forward with progress notes, concerns exist about patient safety issues from the use of potential inaccurate or outdated information to achieve increased efficiency of documentation...
August 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28736075/editorial-positive-developments-for-jcis
#5
EDITORIAL
Teresa Bandosz, Debora Berti, Julian Eastoe, Arthur Hubbard, Arturo Lopez-Quintela, Max Lu, Martin Malmsten, Gengfeng Zheng
No abstract text is available yet for this article.
June 21, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28735040/co-encapsulation-of-paclitaxel-and-c6-ceramide-in-tributyrin-containing-nanocarriers-improve-co-localization-in-the-skin-and-potentiate-cytotoxic-effects-in-2d-and-3d-models
#6
Vanessa F M Carvalho, Amanda Migotto, Daniela V Giacone, Débora P de Lemos, Thalita B Zanoni, Silvya S Maria-Engler, Leticia V Costa-Lotufo, Luciana B Lopes
Considering that tumor development is generally multifactorial, therapy with a combination of agents capable of potentiating cytotoxic effects is promising. In this study, we co-encapsulated C6 ceramide (0.35%) and paclitaxel (0.50%) in micro and nanoemulsions containing tributyrin (a butyric acid pro-drug included for potentiation of cytotoxicity), and compared their ability to co-localize the drugs in viable skin layers. The nanoemulsion delivered 2- and 2.4-fold more paclitaxel into viable skin layers of porcine skin in vitro at 4 and 8h post-application than the microemulsion, and 1...
July 19, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28732846/physicochemical-study-of-mixed-systems-composed-by-bovine-caseinate-and-the-galactomannan-from-gleditsia-amorphoides
#7
Débora N López, Micaela Galante, Estela M Alvarez, Patricia H Risso, Valeria Boeris
Model systems formed by sodium caseinate (NaCAS) and espina corona gum (ECG) were studied. There was no evidence of attractive interactions between NaCAS and ECG macromolecules. Aqueous mixtures of NaCAS and ECG phase-separate segregatively over a wide range of concentrations. According to the images obtained by confocal laser scanning microscopy, NaCAS particles form larger protein aggregates when ECG is present in the system. An increase in the hydrodynamic diameter of NaCAS particles, as a result of ECG addition, was also observed by light scattering in diluted systems...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28732048/wolbachia-and-dengue-virus-infection-in-the-mosquito-aedes-fluviatilis-diptera-culicidae
#8
Jéssica Barreto Lopes Silva, Debora Magalhães Alves, Vanessa Bottino-Rojas, Thiago Nunes Pereira, Marcos Henrique Ferreira Sorgine, Eric Pearce Caragata, Luciano Andrade Moreira
Dengue represents a serious threat to human health, with billions of people living at risk of the disease. Wolbachia pipientis is a bacterial endosymbiont common to many insect species. Wolbachia transinfections in mosquito disease vectors have great value for disease control given the bacterium's ability to spread into wild mosquito populations, and to interfere with infections of pathogens, such as dengue virus. Aedes fluviatilis is a mosquito with a widespread distribution in Latin America, but its status as a dengue vector has not been clarified...
2017: PloS One
https://www.readbyqxmd.com/read/28728503/facilitators-and-barriers-to-international-collaboration-in-spinal-cord-injury-results-from-a-survey-of-clinicians-and-researchers
#9
Vanessa K Noonan, Elaine Chan, Kent Bassett-Spiers, David J Berlowitz, Fin Biering-Sørensen, Susan Charlifue, Marnie Graco, Keith C Hayes, Jane Horsewell, Phalgun Joshi, Debora Markelis, Verna Smith, Zeina Waheed, Doug J Brown
International collaboration in spinal cord injury (SCI) clinical research is necessary to overcome the challenges often encountered by clinicians and researchers including participant recruitment, high cost and the need for highly specialized expertise. However, international collaboration poses its own obstacles. The objective of this study was to conduct an international online survey to assess barriers and facilitators to international SCI clinical research, potential initiatives to facilitate future collaborations and the use of SCI-specific data sets and standards...
July 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28724016/deinstitutionalization-of-long-stay-patients-in-a-psychiatric-hospital-in-rio-de-janeiro
#10
Paulo Roberto Fagundes da Silva, Maria Cecília de Araújo Carvalho, Maria Tavares Cavalcanti, Rodrigo Cunha Echebarrena, Adriana Santos de Mello, Catarina Magalhães Dahl, Débora Bastos de Lima, Flávia Mitkiewicz de Souza
Critical Time Intervention (CTI) is a time-limited mental health intervention offered to people with mental disorders during critical/transition periods. This study assesses the impact of CTI-BR on social performance and quality of life within a population in the process of deinstitutionalization, after long-term hospitalization in a psychiatric institution. The study population was split into two groups, one of which received CTI plus the regular care. Results showed no advantage of the intervention compared to the regular programs provided by the institution...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28721440/selectivity-of-plasma-membrane-calcium-atpase-pmca-mediated-extrusion-of-toxic-divalent-cations-in-vitro-and-in-cultured-cells
#11
Mariela S Ferreira-Gomes, Irene C Mangialavori, Mallku Q Ontiveros, Debora E Rinaldi, Jorge Martiarena, Sandra V Verstraeten, Juan Pablo F C Rossi
In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca(2+) homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca(2+)-binding proteins and/or Ca(2+) pumps. The plasma membrane calcium pump (PMCA) maintains Ca(2+) homeostasis in eukaryotic cells by mediating the efflux of this cation in a process coupled to ATP hydrolysis. The aim of this work was to investigate both in vitro and in cultured cells if other divalent cations (Sr(2+), Ba(2+), Co(2+), Cd(2+), Pb(2+) or Be(2+)) could be transported by PMCA...
July 18, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28720937/quality-characteristics-of-broiler-chicken-meat-from-free-range-and-industrial-poultry-system-for-the-consumers
#12
Débora Cristina Fernandes da Silva, Alex Martins Varela de Arruda, Alex Augusto Gonçalves
ABSTRACT: The aim of this study was to determine and compare the quality parameters of broiler chicken meat from free-range and industrial poultry system. Proximate composition, color, pH, shear force, microbial quality and sensory characteristics were evaluated. Both free-range and industrial chicken meat presented PSE (pale, soft and exudative) anomaly (L* > 53). An inverse correlation between lightness, pH and shear force was observed. The free range broiler meat had higher yellow color (b* 11...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28719236/applying-an-artificial-neural-network-model-for-developing-a-severity-score-for-patients-with-hereditary-amyloid-polyneuropathy
#13
Shenia Novis, Felipe Machado, Victor B Costa, Debora Foguel, Marcia W Cruz, José Manoel de Seixas
Hereditary (familial) amyloid polyneuropathy (FAP) is a systemic disease that includes a sensorimotor polyneuropathy related to transthyretin (TTR) mutations. So far, a scale designed to classify the severity of this disease has not yet been validated. This work proposes the implementation of an artificial neural network (ANN) in order to develop a severity scale for monitoring the disease progression in FAP patients. In order to achieve this goal, relevant symptoms and laboratory findings were collected from 98 Brazilian patients included in THAOS - the Transthyretin Amyloidosis Outcomes Survey...
July 18, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28718635/undervalued-n3-coordination-revealed-in-the-cisplatin-complex-with-2-deoxyadenosine-5-monophosphate-by-a-combined-irmpd-and-theoretical-study
#14
Barbara Chiavarino, Maria Elisa Crestoni, Simonetta Fornarini, Debora Scuderi, Jean-Yves Salpin
The complex obtained by the reaction of cisplatin and 2'-deoxyadenosine-5'-monophosphate (5'-dAMP) in water has been isolated and detected by electrospray ionization mass spectrometry. The so-formed cis-[PtCl(NH3)2(5'-dAMP)](+) complex has been studied in detail by infrared multiple photon dissociation (IRMPD) spectroscopy in two spectral ranges, namely, 700-1900 and 2800-3800 cm(-1), backed by quantum-chemical calculations at the B3LYP/LACV3P/6-311G** level of theory. In agreement with the computational results, the vibrational spectroscopic characterization of cis-[PtCl(NH3)2(5'-dAMP)](+) shows that the sampled ionic population comprises two major isomers, differentiated in the X-H stretching region by their distinct fragmentation patterns...
July 18, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28715118/microrna159-targeted-slgamyb-transcription-factors-are-required-for-fruit-set-in-tomato
#15
Eder Marques da Silva, Geraldo Felipe Ferreira E Silva, Débora Brussolo Bidoia, Mariana da Silva Azevedo, Frederico Almeida de Jesus, Lilian Ellen Pino, Lázaro Eustáquio Pereira Peres, Esther Carrera, Isabel López-Díaz, Fabio Tebaldi Silveira Nogueira
The transition from flowering to fruit production, namely fruit set, is crucial to ensure successful sexual plant reproduction. Although studies have described the importance of hormones (i.e., auxin and gibberelins) in controlling fruit set after pollination and fertilization, the role of microRNA-based regulation during ovary development and fruit set is still poorly understood. Here we show that microRNA159/GAMYB1 and -2 pathway (the miR159/GAMYB1/2 module) is crucial for tomato ovule development and fruit set...
July 17, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28711858/size-distribution-of-extracellular-vesicles-by-optical-correlation-techniques
#16
Costanza Montis, Andrea Zendrini, Francesco Valle, Sara Busatto, Lucia Paolini, Annalisa Radeghieri, Annalisa Salvatore, Debora Berti, Paolo Bergese
Understanding the colloidal properties of extracellular vesicles (EVs) is key to advance fundamental knowledge in this field and to develop effective EV-based diagnostics, therapeutics and devices. Determination of size distribution and of colloidal stability of purified EVs resuspended in buffered media is a complex and challenging issue - because of the wide range of EV diameters (from 30 to 2000nm), concentrations of interest and membrane properties, and the possible presence of co-isolated contaminants with similar size and densities, such as protein aggregates and fat globules - which is still waiting to be fully addressed...
July 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28711464/personality-and-survival-in-older-age-the-role-of-lifestyle-behaviors-and-health-status
#17
Debora Rizzuto, Enrico Mossello, Laura Fratiglioni, Giola Santoni, Hui-Xin Wang
OBJECTIVE: We intended to assess the relationship between personality and survival in an older population and to explore the role of lifestyle behaviors and health status as potential mediators. DESIGN: Population-based cohort study. SETTING: Swedish National Study of Aging and Care in Kungsholmen, Sweden. PARTICIPANTS: 2,298 adults aged 60 or more years, without dementia or depression, followed for 11 years. MEASUREMENTS: Personality (extraversion, neuroticism, and openness) was assessed with a shortened version of the NEO-Five Factor Inventory...
June 8, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28709587/reference-values-for-the-bilateral-heel-rise-test
#18
Débora Pantuso Monteiro, Raquel Rodrigues Britto, Guilherme Augusto de Freitas Fregonezi, Fernando Augusto Lavezzo Dias, Marconi Gomes da Silva, Danielle Aparecida Gomes Pereira
BACKGROUND: The bilateral heel-rise test is an instrument that evaluates the performance of the triceps surae. Normative parameters need to be established for the use of the heel-rise test in clinical practice. OBJECTIVE: To determine the reference values for the bilateral heel-rise test. METHODS: This cross-sectional study assessed healthy subjects using the bilateral heel-rise test. We analyzed the number of repetitions, time (in seconds), and repetition rate (repetitions/second) during execution of the heel-rise test, until the point of voluntary fatigue...
July 3, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28708048/quantitative-and-structural-analyses-of-the-in-vitro-and-ex-vivo-biofilm-forming-ability-of-dermatophytes
#19
Raimunda Sâmia Nogueira Brilhante, Edmilson Emanuel Monteiro Correia, Glaucia Morgana de Melo Guedes, Vandbergue Santos Pereira, Jonathas Sales de Oliveira, Silviane Praciano Bandeira, Lucas Pereira de Alencar, Ana Raquel Colares de Andrade, Débora de Souza Collares Maia Castelo-Branco, Rossana de Aguiar Cordeiro, Adriana de Queiroz Pinheiro, Lúcio Jackson Queiroz Chaves, Waldemiro de Aquino Pereira Neto, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
PURPOSE: The aim of this study was to evaluate the in vitro and ex vivo biofilm-forming ability of dermatophytes on a nail fragment. METHODOLOGY: Initially, four isolates of Trichophyton rubrum, six of Trichophyton tonsurans, three of Trichophyton mentagrophytes, ten of Microsporum canis and three of Microsporum gypseum were tested for production biomass by crystal violet assay. Then, one strain per species presenting the best biofilm production was chosen for further studies by optical microscopy (Congo red staining), confocal laser scanning (LIVE/DEAD staining) and scanning electron (secondary electron) microscopy...
July 15, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28708036/amniotic-fluid-cells-show-higher-pluripotency-related-gene-expression-than-allantoic-fluid-cells
#20
Debora Kehl, Melanie Generali, Sabrina Görtz, Diego Geering, Jaroslav Slamecka, Simon P Hoerstrup, Ulrich Bleul, Benedikt Weber
Amniotic fluid represents an abundant source of multipotent stem cells, referred as broadly mul-tipotent given their differentiation potential and expression of pluripotency-related genes. How-ever, the origin of this broadly multipotent cellular fraction is not fully understood. Several sources have been proposed so far, including embryonic and extra-embryonic tissues. In this re-gard, the ovine developmental model uniquely allows for direct comparison of fetal fluid-derived cells from two separate fetal fluid cavities, the allantois and the amnion, over the entire duration of gestation...
July 14, 2017: Stem Cells and Development
keyword
keyword
111773
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"