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https://www.readbyqxmd.com/read/28319312/exploratory-study-of-australian-aged-care-staff-knowledge-and-attitudes-of-later-life-sexuality
#1
Yung-Hui Chen, Cindy Jones, Debora Osborne
OBJECTIVE: To explore aged care staff knowledge and attitudes towards later life sexuality and attitudes about intimacy in people with dementia. METHODS: Fifty-two care staff working in two aged care facilities with secure dementia care units were recruited. Knowledge and attitudes on later life sexuality and attitudes towards later life sexuality in people with dementia were surveyed using the Aging Sexual Knowledge and Attitudes Scale and the selected eight items of the Staff Attitudes about Intimacy and Dementia, respectively...
March 20, 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/28318175/psychosocial-care-in-the-department-of-pediatric-hematology-and-oncology-of-public-hospitals-in-argentina
#2
Débora Farberman, Teresa Méndez, Leticia García, Lucía Salvia, Silvia Otarolac
BACKGROUND: Blood diseases and cancer are part of a group of rare conditions in pediatrics. In general, cancer treatments are prolonged (months or years), so psychosocial support has been introduced to provide comprehensive care to these patients. OBJECTIVE: To explore psychosocial care provided at the public hospitals of Argentina to children and adolescents with cancer. Population and Methods. An electronic questionnaire was sent to the heads of the Departments of Hematology and Oncology, Mental Health, and Social Services of 27 public hospitals providing care to pediatric patients with cancer...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28317702/rapid-determination-of-flavonoids-and-phenolic-acids-in-grape-juices-and-wines-by-rp-hplc-dad-method-validation-and-characterization-of-commercial-products-of-the-new-brazilian-varieties-of-grape
#3
Carla Valéria da Silva Padilha, Gabriela Aquino Miskinis, Marcelo Eduardo Alves Olinda de Souza, Giuliano Elias Pereira, Débora de Oliveira, Marilde Terezinha Bordignon-Luiz, Marcos Dos Santos Lima
A method for rapid determination of phenolic compounds by reversed-phase high-performance liquid chromatography (RP-HPLC), using a new column of faster resolution was validated and used to characterize commercial products produced with new grape Brazilian varieties of Northeast of Brazil. The in vitro antioxidant activity was also measured. The method showed linearity (R>0.9995), good precision (CV%<2.78), recovery (91.8-105.1%) and limits of detection (0.04-0.85mgL(-1)) and quantification (0.04-1.41mgL(-1)) according to other methods previously published with the difference of a run time of only 25min...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28316976/mutagenic-and-cytotoxicity-lqb-123-profile-safety-and-tripanocidal-effect-of-a-phenyl-t-butylnitrone-derivative
#4
Mauricio Peixoto Cupello, Francis Monique Saraiva, Pedro Ippolito, Andréia da Silva Fernandes, Rubem Figueiredo Sadoko Menna-Barreto, Debora de Sousa Dos Santos Costa, Jessica Isis Oliveira Paula, Paulo Roberto Ribeiro Costa, Natália Pereira Nogueira, Israel Felzenswalb, Ayres Guimarães Dias, Marcia Cristina Paes
The therapeutic options for Chagas disease are limited and its treatment presents a number of drawbacks including toxicity, drug resistance, and insufficient effectiveness against the chronic stage of the disease. Therefore, new therapeutical options are mandatory. In the present work, we evaluated the effect of a phenyl-tert-butylnitrone (PBN) derivate, LQB 123, against Trypanosoma cruzi forms. LQB 123 presented a trypanocidal effect against bloodstream trypomastigotes (IC50 = 259.4 ± 6.1 μM) and intracellular amastigotes infecting peritoneal macrophages (IC50 = 188...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28314323/bevacizumab-combined-with-chemotherapy-in-children-affected-by-hepatocellular-carcinoma-a-single-center-experience
#5
Maria Debora DE Pasquale, Jean de Ville de Goyet, Lidia Monti, Chiara Grimaldi, Alessandro Crocoli, Aurora Castellano
BACKGROUND: Hepatocellular carcinoma (HCC) is very rare in children and is traditionally associated with a poor prognosis because many patients are not amenable to conventional resection, even in the absence of metastatic disease. For patients with locally advanced or metastatic tumors, conventional chemotherapy appears to offer limited survival benefits. PATIENTS AND METHODS: We report a case series of five consecutive pediatric patients with HCC who were treated with bevacizumab along with conventional platinum-based chemotherapy...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28306158/effect-of-chronic-diseases-and-multimorbidity-on-survival-and-functioning-in-elderly-adults
#6
Debora Rizzuto, René J F Melis, Sara Angleman, Chengxuan Qiu, Alessandra Marengoni
OBJECTIVES: To determine the effect of chronic disorders and their co-occurrence on survival and functioning in community-dwelling older adults. DESIGN: Population-based cohort study. SETTING: Kungsholmen, Stockholm, Sweden. PARTICIPANTS: Individuals aged 78 and older examined by physicians four times over 11 years (N = 1,099). MEASUREMENTS: Chronic diseases (grouped according to 10 organ systems according to the International Classification of Diseases, Tenth Revision, code) and multimorbidity (≥2 coexisting chronic diseases) were evaluated in terms of mortality, population attributable risk of death, median years of life lost, and median survival time with and without disability (need of assistance in ≥1 activities of daily living)...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28303497/n-acetylcysteine-prevents-alcohol-related-neuroinflammation-in-rats
#7
Ricardo Schneider, Solange Bandiera, Débora Guerini Souza, Bruna Bellaver, Greice Caletti, André Quincozes-Santos, Elaine Elisabetsky, Rosane Gomez
Alcoholism has been characterized as a systemic pro-inflammatory condition and alcohol withdrawal has been linked to various changes in the brain homeostasis, including oxidative stress and glutamate hyperactivity. N-acetylcysteine (NAC) is an anti-inflammatory and antioxidant multi-target drug with promising results in psychiatry, including drug addiction. We assessed the effects of NAC on the serum and brain inflammatory cytokines after cessation of chronic alcohol treatment in rats. Male Wistar rats received 2 g/kg alcohol or vehicle twice a day by oral gavage for 30 days...
March 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28302781/genome-sequence-of-cauliflower-mosaic-virus-identified-in-earwigs-doru-luteipes-through-a-metagenomic-approach
#8
Márcio Tadeu Godinho, Débora Pires Paula, Arvind Varsani, Simone Graça Ribeiro
Here we report the first complete genome sequence of a cauliflower mosaic virus from Brazil, obtained from the gut content of the predator earwig (Doru luteipes). This virus has a genome of 8,030 nucleotides (nt) and shares 97% genome-wide identity with an isolate from Argentina.
March 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28300968/-use-of-medicines-before-and-during-pregnancy-prevalence-and-associated-factors
#9
Débora Bomfim Costa, Helena Lutescia Luna Coelho, Djanilson Barbosa Dos Santos
This cross-sectional prospective nested cohort study aimed to assess the prevalence of use of medication before and during pregnancy and associated factors in women in a municipality in the countryside of Bahia State, Brazil. Data were collected with a structured questionnaire applied to pregnant women at their prenatal visits at health units. Prevalence rates for use of medication before and during pregnancy were 52.1% and 84.7%, respectively. The following were associated with use of medication before pregnancy: age ≥ 30 years, non-white skin color, first prenatal visit after the 1st trimester, and economic classes C/D/E...
March 9, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28295690/azole-resistance-in-candida-albicans-from-animals-highlights-on-efflux-pump-activity-and-gene-overexpression
#10
Marcos Fábio Gadelha Rocha, Silviane Praciano Bandeira, Lucas Pereira de Alencar, Luciana Magalhães Melo, Jamille Alencar Sales, Manoel de Araújo Neto Paiva, Carlos Eduardo Cordeiro Teixeira, Débora de Souza Collares Maia Castelo-Branco, Waldemiro de Aquino Pereira-Neto, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, Raimunda Sâmia Nogueira Brilhante
This study investigated potential mechanisms of azole resistance among Candida albicans from animals, including efflux pump activity, ergosterol content and gene expression. For this purpose, 30 azole-resistant C. albicans strains from animals were tested for their antifungal susceptibility, according to document M27-A3, efflux pump activity by rhodamine 6G test, ergosterol content and expression of the genes CDR1, CDR2, MDR1, ERG11 by RT-qPCR. These strains were resistant to at least one azole derivative...
March 10, 2017: Mycoses
https://www.readbyqxmd.com/read/28294472/knowledge-and-practice-regarding-dengue-and-chikungunya-a-cross-sectional-study-among-healthcare-workers-and-community-in-northern-tanzania
#11
Debora C Kajeguka, Rachelle E Desrochers, Rose Mwangi, Maseke R Mgabo, Michael Alifrangis, Reginald A Kavishe, Franklin W Mosha, Manisha A Kulkarni
OBJECTIVE: To investigate knowledge and prevention practices regarding dengue and chikungunya amongst community members, as well as knowledge, treatment and diagnostic practices among healthcare workers. METHOD: We conducted a cross-sectional survey with 125 community members and 125 healthcare workers from 13 health facilities in six villages in the Hai district of Tanzania. A knowledge score was generated based on participant responses to a structured questionnaire, with a score of 40 or higher (out of 80 and 50 total scores for community members and healthcare workers, respectively) indicating good knowledge...
March 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28294319/grpr-antagonist-protects-from-drug-induced-liver-injury-by-impairing-neutrophil-chemotaxis-and-motility
#12
Rafael S Czepielewski, Natália Jaeger, Pedro E Marques, Maísa M Antunes, Maurício M Rigo, Débora M Alvarenga, Rafaela V Pereira, Rodrigo D da Silva, Tiago G Lopes, Vinícius D da Silva, Bárbara N Porto, Gustavo B Menezes, Cristina Bonorino
Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF), where hepatocyte necrotic products trigger liver inflammation, release of CXCR2 ligands (IL-8) and other neutrophil chemotactic molecules. Liver infiltration by neutrophils is a major cause of the life threatening tissue damage that ensues. A GRPR (gastrin-releasing peptide receptor) antagonist impairs IL-8-induced neutrophil chemotaxis in vitro. We investigated its potential to reduce acetaminophen-induced ALF, neutrophil migration and mechanisms underlying this phenomenon...
March 10, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28294106/coherent-and-incoherent-charge-transport-in-linear-triple-quantum-dots
#13
L Debora Contreras-Pulido, Martin Bruderer
One of the fundamental questions in quantum transport is how charge transfer through complex nanostructures is influenced by quantum coherence. We address this issue for linear triple quantum dots by comparing a Lindblad density matrix description with a Pauli rate equation approach and analyze the corresponding zero-frequency counting statistics of charge transfer. The impact of decaying coherences of the density matrix due to dephasing is also studied. Our findings reveal that the sensitivity to coherence shown by shot noise and skewness, in particular in the limit of large coupling to the drain reservoir, can be used to unambiguously evidence coherent processes involved in charge transport across triple quantum dots...
March 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28294043/polysaccharide-based-materials-associated-with-or-coordinated-to-gold-nanoparticles-synthesis-and-medical-application
#14
Débora P Facchi, Joziel A da Cruz, Elton G Bonafé, Antonio G B Pereira, André R Fajardo, Sandro A S Venter, Johny P Monteiro, Edvani C Muniz, Alessandro F Martins
BACKGROUND: Gold nanoparticles (AuNPs) have enormous potential for application in imaging, diagnosis, and therapies in the medical field. AuNPs are renowned for their localized surface plasmon resonance (LSPR) properties, large surface area, and biocompatibility with body fluids. Further, AuNPs have featured prominently in new methodologies for cancer treatments, like photothermal and imaging therapies. Although AuNPs present enormous potential for application in the medical field, their instability under physiological conditions prevents further uses...
March 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28293169/brain-metabolism-changes-in-patients-infected-with-htlv-1
#15
Manuel Schütze, Luiz C F Romanelli, Daniela V Rosa, Anna B F Carneiro-Proietti, Rodrigo Nicolato, Marco A Romano-Silva, Michael Brammer, Débora M de Miranda
The Human T-cell leukemia virus type-I (HTLV-1) is the causal agent of HTLV-associated myelopathy/Tropical Spastic Paraparesis (HAM/TSP). HAM/TSP is the result of demyelination and cell death in the spinal cord and disruption of the blood-brain barrier (BBB), mediated by a virus-induced inflammatory response. In this study, we applied Positron Emission Tomography with 18F-fluordeoxyglucose (18F-FDG PET) to evaluate brain metabolism in a group of 47 patients infected with HTLV-1, and 18 healthy controls. Patients were divided into three groups according to their neurological symptoms...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28289519/challenges-in-the-chemotherapy-of-chagas-disease-looking-for-possibilities-related-to-the-differences-and-similarities-between-the-parasite-and-host
#16
REVIEW
Vitor Sueth-Santiago, Debora Decote-Ricardo, Alexandre Morrot, Celio Geraldo Freire-de-Lima, Marco Edilson Freire Lima
Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host.
February 26, 2017: World Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28289418/fighting-viral-infections-and-virus-driven-tumors-with-cytotoxic-cd4-t-cells
#17
REVIEW
Elena Muraro, Anna Merlo, Debora Martorelli, Michela Cangemi, Silvia Dalla Santa, Riccardo Dolcetti, Antonio Rosato
CD4(+) T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and specific functions. Nonetheless, a growing body of evidence indicates that CD4(+) T cells can also exert a direct effector activity, which depends on intrinsic cytotoxic properties acquired and carried out along with the evolution of several pathogenic infections...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28286909/pygoscelis-antarcticus-feathers-as-bioindicator-of-trace-element-risk-in-marine-environments-from-barton-peninsula-25-de-mayo-king-george-island-antarctica
#18
Soledad Perez Catán, Debora Bubach, Carla Di Fonzo, Laura Dopchiz, Maria Arribére, Martin Ansaldo
We report the contents of elements in feathers of Chinstrap penguin (Pygoscelis antarcticus), which had not been informed up to now, such as silver and bromine and others listed as hazardous by the United States Environmental Protection Agency as arsenic, cobalt, chromium, and mercury. Analyses of the element concentrations in feathers, adult and chicken, from Barton Peninsulas at 25 de Mayo (King George) Island, South Shetlands, were made by Instrumental Neutron Activation Analysis. Samarium, lanthanum a, thorium, and uranium concentrations in Chinstrap penguin feathers were below 0...
March 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28286153/safety-of-c1-inhibitor-concentrate-use-for-hereditary-angioedema-in-pediatric-patients
#19
Paula Busse, James Baker, Inmaculada Martinez-Saguer, Jonathan A Bernstein, Timothy Craig, Markus Magerl, Marc Riedl, Ralph Shapiro, Michael Frank, William Lumry, Jeffrey Rosch, Jonathan Edelman, Debora Williams-Herman, Henrike Feuersenger, Mikhail Rojavin
No abstract text is available yet for this article.
March 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28285410/epithelial-cell-enhanced-metabolism-by-low-level-laser-therapy-and-epidermal-growth-factor
#20
Fernanda Gonçalves Basso, Taisa Nogueira Pansani, Lais Medeiros Cardoso, Mariana Citta, Diana Gabriela Soares, Débora Salles Scheffel, Josimeri Hebling, Carlos Alberto de Souza Costa
Reepithelialization and wound closure are the desired outcome for several ulcerative conditions. Such resolution reduces the possibility of wound contamination and maintenance of the injury and improves the reestablishment of tissue morphology and functions. Investigators are seeking adjuvant therapies that can accelerate wound healing and are developing new strategies for clinical applications. This study compared the effects of epidermal growth factor (EGF) application and low-level laser therapy (LLLT) on cultured epithelial cells...
March 11, 2017: Lasers in Medical Science
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