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https://www.readbyqxmd.com/read/28635380/inorganic-nanoparticles-as-potential-regulators-of-immune-response-in-dendritic-cells
#1
Silvia Fogli, Costanza Montis, Sara Paccosi, Angela Silvano, Elena Michelucci, Debora Berti, Alberto Bosi, Astrid Parenti, Paolo Romagnoli
AIM: The spontaneous adsorption of proteins on nanoparticles (NPs) in biological media is exploited to prepare complexes of NPs and proteins from cancer cells' lysates for application in cancer immunotherapy. MATERIALS & METHODS: Gold (Au) and silica NPs were synthesized, incubated with cancer cells' lysates and characterized. Dendritic cells (DCs) were challenged with protein-coated NPs, their maturation, viability and morphology were evaluated and lymphocytes T proliferation was determined...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28631831/spatial-and-temporal-trends-and-flow-dynamics-of-glyphosate-and-other-pesticides-within-an-agricultural-watershed-in-argentina
#2
Débora J Pérez, Elena Okada, Eduardo De Gerónimo, Mirta L Menone, Virginia C Aparicio, José L Costa
In the present study, we evaluated the spatial and temporal trends of current use pesticides in surface water and sediments and to determine its relation with hydrological stream dynamics within the agricultural watershed of El Crespo stream. We sampled two contrasting sites: Site 1 (upstream) surrounded by agricultural lands, and Site 2 (downstream) surrounded by natural grasslands. Most of the applied pesticides (i.e. glyphosate, 2,4-D, atrazine, tebuconazole and imidacloprid) were detected in high frequencies in surface water samples at both sites...
June 20, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28630546/the-battle-over-abortion-rights-in-brazil-s-state-arenas-1995-2006
#3
Marta Rodriguez De Assis Machado, Débora Alves Maciel
This article proposes a relational approach to the study of abortion law reform in Brazil. It focuses on the interaction of pro-choice and anti-abortion movements in different state arenas and political contexts. It details the emergence of a strategic action field on abortion during the Brazilian re-democratization process and the National Constituent Assembly. We offer analysis on pro-choice and anti-abortion mobilization in state arenas-mainly in the executive and legislative powers-during the two terms of President Fernando Henrique Cardoso (FHC), 1995-1998 and 1999-2002, and the first term of President Luís Inácio Lula da Silva (Lula), 2003-2006...
June 2017: Health and Human Rights
https://www.readbyqxmd.com/read/28628982/the-physiology-of-trace-elements-in-biological-methane-production
#4
Annalisa Abdel Azim, Christian Pruckner, Philipp Kolar, Ruth-Sophie Taubner, Debora Fino, Guido Saracco, Filipa L Sousa, Simon K-M R Rittmann
Trace element (TE) requirements of Methanothermobacter okinawensis and Methanothermobacter marburgensis were examined in silico, and using closed batch and fed-batch cultivation experiments. In silico analysis revealed genomic differences among the transport systems and enzymes related to the archaeal Wood-Ljungdahl pathway of these two methanogens. M. okinawensis responded to rising concentrations of TE by increasing specific growth rate (µ) and volumetric productivity (MER) during closed batch cultivation, and can grow and produce methane (CH4) during fed-batch cultivation...
June 2, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28626451/dependency-of-b-1-cells-in-the-maintenance-of-splenic-interleukin-10-producing-cells-and-impairment-of-macrophage-resistance-in-visceral-leishmaniasis
#5
Angélica Fernandes Arcanjo, Dirlei Nico, Gabriellen Menezes Migliani de Castro, Yasmin da Silva Fontes, Paula Saltarelli, Debora Decote-Ricardo, Marise P Nunes, Antônio Ferreira-Pereira, Clarisa B Palatnik-de-Sousa, Célio G Freire-de-Lima, Alexandre Morrot
Visceral leishmaniasis is a neglected disease caused by Leishmania protozoa parasites transmitted by infected sand fly vectors. This disease represents the second in mortality among tropical infections and is associated to a profound immunosuppression state of the host. The hallmark of this infection-induced host immunodeviation is the characteristic high levels of the regulatory interleukin-10 (IL-10) cytokine. In the present study, we investigated the role of B-1 cells in the maintenance of splenic IL-10 levels that could interfere with resistance to parasite infection...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28625546/the-lateral-parabrachial-nucleus-and-central-angiotensinergic-mechanisms-in-the-control-of-sodium-intake-induced-by-different-stimuli
#6
Camila F Roncari, Richard B David, Patrícia M De Paula, Débora S A Colombari, Laurival A De Luca, Eduardo Colombari, José V Menani
Angiotensin II (ANG II) is a typical facilitatory stimulus for sodium appetite. Surprisingly, hyperosmolarity and central cholinergic stimulation, two classical antinatriorexigenic stimuli, also facilitate NaCl intake when they are combined with injections of the α2-adrenoceptor/imidazoline agonist moxonidine into the lateral parabrachial nucleus (LPBN). In the present study, we tested the relative importance of central angiotensinergic and cholinergic mechanisms for the control of water and NaCl intake by combining different dipsogenic or natriorexigenic stimuli with moxonidine injection into the LPBN...
June 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28624391/efficacy-of-melatonin-il-25-and-siil-17b-in-tumorigenesis-associated-properties-of-breast-cancer-cell-lines
#7
Gabriela Bottaro Gelaleti, Thaiz Ferraz Borin, Larissa Bazela Maschio-Signorini, Marina Gobbe Moschetta, Bruna Victorasso Jardim-Perassi, Guilherme Berto Calvinho, Mariana Castilho Facchini, Alicia M Viloria-Petit, Debora Aparecida Pires de Campos Zuccari
Mammary tumorigenesis can be modulated by melatonin, which has oncostatic action mediated by multiple mechanisms, including the inhibition of the activity of transcription factors such as NF-κB and modulation of interleukins (ILs) expression. IL-25 is an active cytokine that induces apoptosis in tumor cells due to differential expression of its receptor (IL-17RB). IL-17B competes with IL-25 for binding to IL-17RB in tumor cells, promoting tumorigenesis. This study purpose is to address the possibility of engaging IL-25/IL-17RB signaling to enhance the effect of melatonin on breast cancer cells...
June 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28623959/the-impact-of-wolbachia-infection-on-the-rate-of-vertical-transmission-of-dengue-virus-in-brazilian-aedes-aegypti
#8
Etiene Casagrande Pacidônio, Eric Pearce Caragata, Debora Magalhães Alves, João Trindade Marques, Luciano Andrade Moreira
BACKGROUND: Wolbachia pipientis is a common endosymbiotic bacterium of arthropods that strongly inhibits dengue virus (DENV) infection and transmission in the primary vector, the mosquito Aedes aegypti. For that reason, Wolbachia-infected Ae. aegypti are currently being released into the field as part of a novel strategy to reduce DENV transmission. However, there is evidence that DENV can be transmitted vertically from mother to progeny, and this may help the virus persist in nature in the absence of regular human transmission...
June 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28622460/antifungal-activity-of-tyrosol-and-farnesol-used-in-combination-against-candida-species-in-the-planktonic-state-or-forming-biofilms
#9
Douglas Roberto Monteiro, Laís Salomão Arias, Renan Aparecido Fernandes, Lucas Fernando Deszo da Silva, Manoel Olavo Valentim Fernandes de Castilho, Thaís Oliveira da Rosa, Ana Paula Miranda Vieira, Fabiana Gouveia Straioto, Débora Barros Barbosa, Alberto Carlos Botazzo Delbem
AIM: This study examined the antifungal activity of the combination of tyrosol and farnesol against Candida albicans and Candida glabrata in the planktonic state or forming biofilms. METHODS AND RESULTS: The effect of drug association against Candida planktonic cells was assessed by the fractional inhibitory concentration index. Mono and dual-species biofilms were developed (24 h) and the compounds, applied during 3 days, with 2 daily treatments of 1 minute each...
June 16, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28620374/canine-macrophage-dh82-cell-line-as-a-model-to-study-susceptibility-to-trypanosoma-cruzi-infection
#10
Pedro Henrique Braz Mendonça, Raphael Francisco Dutra Barbosa da Rocha, Julliane Brito de Braz Moraes, Isabel Ferreira LaRocque-de-Freitas, Jorgete Logullo, Alexandre Morrot, Marise Pinheiro Nunes, Celio Geraldo Freire-de-Lima, Debora Decote-Ricardo
Trypanosoma cruzi is an obligatory intracellular protozoan parasite, and it is the etiological agent of Chagas' disease that is endemic in the Americas. In addition to humans, a wide spectrum of mammals can be infected by T. cruzi, including dogs. Dogs develop acute and chronic disease, similar to human infection. T. cruzi can infect almost all cell types and after cell invasion, the metacyclics trypomastigotes localize in the cytoplasm, where they transform into amastigotes, the replicative form of T. cruzi in mammals...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28617775/-doctors-and-nurses-perceptions-of-the-spending-review-in-the-autonomous-province-of-trento-italy
#11
Debora Viviani, Giancarla Carraro, Giovanni Maria Guarrera, Chiara Francesca Dalle Fratte, Annamaria Guarnier, Luisa Saiani
The national expenditure limits set by the spending review has required reorganization and streamlining measures. The present study was conducted in 2015, among 2,020 nurses and 861 doctors in the autonomous province of Trento (Italy), to describe their perceptions of the containment measures introduced in healthcare spending, following the spending review. Results show that nurses and doctors were most affected by the measures regarding staff management (staff turnover rate, reducing overtime and changes in training)...
March 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28614860/primary-fetal-lung-hypoplasia-pflh-imaging-and-clinical-characteristics
#12
Reuven Achiron, Yinon Gilboa, Yishay Salem, Yizhak Jacobson, Lisa Raviv-Zilka, Andreea Cioca, Debora Kidron, Zvi Kivilevitch
Purpose To describe in utero and postnatal imaging and clinical characteristics of primary fetal lung hypoplasia (PFLH). Methods A retrospective review of fetuses and neonates diagnosed in one academic tertiary center during an eleven-year period. Results 12 cases of PFLH were identified. 4 were bilateral and 8 had unilateral involvement. Prenatal sonographic characteristics, postnatal magnetic resonance imaging (MRI), computerized tomographic angiography (CTA), and histologic findings are described...
June 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28613278/ductus-arteriosus-gene-profile-for-fetal-maturation-versus-postnatal-closure
#13
Flavio Coceani, Francesca Scebba, Debora Angeloni
No abstract text is available yet for this article.
June 14, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28613050/meeting-reports-2016-annual-meeting-of-the-sociedad-latinoamericana-de-endocrinolog%C3%A3-a-pedi%C3%A3-trica-slep-buenos-aires-argentina-november-8-11-2016-selected-highlights
#14
Romina Grinspon, Débora Braslavsky, Ana Chiesa, Patricia Papendieck, Patricia Pennisi, Florencia Clement, Ana Vieites, Ana Keselman, Mirta Gryngarten, Analía Freire, María Gabriela Ballerini, Rodolfo Rey, Ignacio Bergadá, Horacio Domené
No abstract text is available yet for this article.
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28612959/early-life-decline-in-neurogenesis-markers-and-age-related-changes-of-trkb-splice-variant-expression-in-the-human-subependymal-zone
#15
Christin Weissleder, Mari A Kondo, Chunhui Yang, Samantha J Fung, Debora A Rothmond, Matthew W Wong, Glenda M Halliday, Mary M Herman, Joel E Kleinman, Maree J Webster, Cynthia Shannon Weickert
Neurogenesis in the subependymal zone (SEZ) declines across the human lifespan and reduced local neurotrophic support is speculated to be a contributing factor. While tyrosine receptor kinase B (TrkB) signalling is critical for neuronal differentiation, maturation and survival, little is known about subependymal TrkB expression changes during postnatal human life. In this study, we used quantitative PCR and in situ hybridisation to determine expression of the cell proliferation marker Ki67, the immature neuron marker doublecortin (DCX) and both full-length (TrkB-TK+) and truncated TrkB receptors (TrkB-TK-) in the human SEZ from infancy to middle age (n=26-35, 41 days-43 years)...
June 14, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28610721/cationic-liposomal-vectors-incorporating-a-bolaamphiphile-for-oligonucleotide-antimicrobials
#16
Marianna Mamusa, Leopoldo Sitia, Francesco Barbero, Angels Ruyra, Teresa Díaz Calvo, Costanza Montis, Ana Gonzalez-Paredes, Grant N Wheeler, Christopher J Morris, Michael McArthur, Debora Berti
Antibacterial resistance has become a serious crisis for world health over the last few decades, so that new therapeutic approaches are strongly needed to face the threat of resistant infections. Transcription factor decoys (TFD) are a promising new class of antimicrobial oligonucleotides with proven in vivo activity when combined with a bolaamphiphilic cationic molecule, 12-bis-THA. These two molecular species form stable nanoplexes which, however, present very scarce colloidal stability in physiological media, which poses the challenge of drug formulation and delivery...
June 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28608987/smarca4-inactivating-mutations-cause-concomitant-coffin-siris-syndrome-microphthalmia-and-small-cell-carcinoma-of-the-ovary-hypercalcemic-type
#17
Edoardo Errichiello, Noor Mustafa, Annalisa Vetro, Lucia Dora Notarangelo, Hugo de Jonge, Berardo Rinaldi, Debora Vergani, Sabrina Rita Giglio, Patrizia Morbini, Orsetta Zuffardi
SMARCA4 chromatin remodeling factor is mutated in 11% of Coffin-Siris syndrome (CSS) patients and in almost all small cell carcinoma of the ovary hypercalcemic type (SCCOHT) tumors. Missense mutations with gain-of-function or dominant-negative effects are associated with CSS, whereas inactivating mutations, leading to loss of SMARCA4 expression, have been exclusively found in SCCOHT. We applied whole exome sequencing to study a 15-year-old patient with mild CSS who concomitantly developed SCCOHT at age 13 years...
June 13, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28605455/risk-profiles-for-injurious-falls-in-people-over-60-a-population-based-cohort-study
#18
Stina Ek, Debora Rizzuto, Laura Fratiglioni, Kristina Johnell, Weili Xu, Anna-Karin Welmer
Background: Although falls in older adults are related to multiple risk factors, these factors have commonly been studied individually. We aimed to identify risk profiles for injurious falls in older adults by detecting clusters of established risk factors and quantifying their impact on fall risk. Methods: Participants were 2566 people, aged ≥60 years, from the population-based Swedish National Study on Aging and Care in Kungsholmen. Injurious falls was defined as hospitalization for or receipt of outpatient care because a fall...
June 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28605285/analysis-of-real-world-health-care-costs-among-immunocompetent-patients-aged-50%C3%A2-years-or-older-with-herpes-zoster-in-the-united-states
#19
Juliana L Meyers, Shweta Madhwani, Debora Rausch, Sean D Candrilli, Girishanthy Krishnarajah, Songkai Yan
Few peer-reviewed publications present real-world United States (US) data describing resource utilization and costs associated with herpes zoster (HZ) and postherpetic neuralgia (PHN). The primary objective of this analysis (GSK study identifier: HO-14-14270) was to assess direct costs associated with HZ and PHN in the US using a retrospective managed care insurance claims database. Patients ≥ 50 y at HZ diagnosis were selected. Patients were excluded if they were immunocompromised before diagnosis or received an HZ vaccine at any time...
June 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28604847/assessment-of-nanoparticles-safety-corrected-absorbance-based-toxicity-test
#20
Debora Bonvin, Heinrich Hofmann, Marijana Mionić Ebersold
We developed a method to correct absorbance-based toxicity tests to remove the influence of the deposited dose of nanoparticles. As a model of absorbance-based toxicity tests, we chose the frequently used MTS test. The corrected cell viabilities obtained with the MTS test matched the results of the fluorescence-based PrestoBlue® test.
June 12, 2017: Analyst
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