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https://www.readbyqxmd.com/read/28319815/shape-dependent-enzyme-like-activity-of-co3o4-nanoparticles-and-their-conjugation-with-his-tagged-egfr-single-domain-antibody
#1
Wei Zhang, Jinlai Dong, Yang Wu, Peng Cao, Lina Song, Ming Ma, Ning Gu, Yu Zhang
In this study, Co3O4 nanopolyhedrons, nanocubes, nanoplates and nanorods were synthesized and characterized. Furthermore, the peroxidase- and catalase-like activities of these Co3O4 nanoparticles (NPs) were studied and influence of the exposed crystal planes was explored. According to their morphology and peroxidase-like activity, dimercaptosuccinic acid (DMSA) modified Co3O4 nanopolyhedrons synthesized via coprecipitation method (Co3O4 NHs) were selected as a proper candidate for the immunohistochemical (IHC) detection of epidermal growth factor receptor (EGFR) expression in non-small cell lung cancer (NSCLC) tissues...
February 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28318160/-phonological-characteristics-and-rehabilitation-training-of-abnormal-velar-in-children-with-functional-articulation-disorders
#2
Xu Lina, Li Feng, Zhang Yanyun, Gao Nan, Hu Mingfang
OBJECTIVE: To explore the phonological characteristics and rehabilitation training of abnormal velar in patients with functional articulation disorders (FAD). METHODS: Eighty-seven patients with FAD were observed of the phonological characteristics of velar. Seventy-two patients with abnormal velar accepted speech training. The correlation and simple linear regression analysis were carried out on abnormal velar articulation and age. RESULTS: The articulation disorder of /g/ mainly showed replacement by /d/, /b/ or omission...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28317870/structural-and-functional-studies-of-a-noncanonical-dicer-from-entamoeba-histolytica
#3
Xiang Yu, Xuhang Li, Lina Zheng, Jinbiao Ma, Jianhua Gan
RNaseIII proteins are dsRNA-specific endonucleases involved in many important biological processes, such as small RNA processing and maturation in eukaryotes. Various small RNAs have been identified in a protozoan parasite Entamoeba histolytica. EhRNaseIII is the only RNaseIII endonuclease domain (RIIID)-containing protein in E. histolytica. Here, we present three crystal structures that reveal several unique structural features of EhRNaseIII, especially the interactions between the two helixes (α1 and α7) flanking the RIIID core domain...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28315819/a-case-report-of-thoracic-endometriosis-a-rare-cause-of-haemothorax
#4
Lina Pankratjevaite, Diana Samiatina-Morkuniene
INTRODUCTION: The presence of endometrial tissue in airways, pleura and lung parenchyma is called thoracic endometriosis syndrome (TES). It is a rare pathology, and typically consists of catamenial pneumothorax, haemothorax, haemoptysis, and pulmonary nodules. We report a case of a 36-year-old woman with thoracic endometriosis causing catamenial haemothorax. CONCLUSIONS: The diagnosis of thoracic endometriosis is complicated and often delayed. TES should be suspected in a reproductive age woman with exacerbating symptoms during the menstruation...
March 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28314114/st-sub-2-sub-80-a-new-fish-marker-for-st-genome-and-genome-analysis-in-triticeae
#5
Long Wang, Qinghua Shi, Handong Su, Yi Wang, Sha Lina, Xing Fan, Kang Houyang, Zhang Haiqin, Yong-Hong Zhou
<b>St</b> genome is one of the most fundamental genomes in Triticeae. Repetitive sequences are widely used to distinguish different genomes or species. The primary objectives of this study are (1) to screen a new sequence that can easily distinguish the chromosome of <b>St</b> and other genome by fluorescence in situ hybridization (FISH); (2) to investigate the genome constitutions of some species remains uncertain and controversial. We used degenerated oligonucleotide primer PCR (Dop-PCR), Dot-blot and FISH to screen new marker for <b>St</b> genome and tested efficiency of this marker in detection <b>St</b> chromosome at different ploidy level...
March 17, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28303253/design-implementation-and-study-protocol-of-a-kindergarten-based-health-promotion-intervention
#6
Susanne Kobel, Olivia Wartha, Tamara Wirt, Jens Dreyhaupt, Christine Lämmle, Eva-Maria Friedemann, Anne Kelso, Claire Kutzner, Lina Hermeling, Jürgen M Steinacker
Inactivity and an unhealthy diet amongst others have led to an increased prevalence of overweight and obesity even in young children. Since most health behaviours develop during childhood health promotion has to start early. The setting kindergarten has been shown as ideal for such interventions. "Join the Healthy Boat" is a kindergarten-based health promotion programme with a cluster-randomised study focussing on increased physical activity, reduced screen media use, and sugar-sweetened beverages, as well as a higher fruit and vegetable intake...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28302790/complete-genome-and-methylome-analysis-of-psychrotrophic-bacterial-isolates-from-lake-untersee-in-antarctica
#7
Alexey Fomenkov, Vladimir N Akimov, Lina V Vasilyeva, Dale T Andersen, Tamas Vincze, Richard J Roberts
This paper describes the complete genome sequences and methylome analysis of six psychrotrophic strains isolated from perennially ice-covered Lake Untersee in Antarctica.
March 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28302166/secreted-phospholipase-a2-of-clonorchis-sinensis-activates-hepatic-stellate-cells-through-a-pathway-involving-jnk-signalling
#8
Yinjuan Wu, Ye Li, Mei Shang, Yu Jian, Caiqin Wang, Adham Sameer A Bardeesi, Zhaolei Li, Tingjin Chen, Lu Zhao, Lina Zhou, Ai He, Yan Huang, Zhiyue Lv, Xinbing Yu, Xuerong Li
BACKGROUND: Secreted phospholipase A2 (sPLA2) is a protein secreted by Clonorchis sinensis and is a component of excretory and secretory products (CsESPs). Phospholipase A2 is well known for its role in liver fibrosis and inhibition of tumour cells. The JNK signalling pathway is involved in hepatic stellate cells (HSCs) activation. Blocking JNK activity with SP600125 inhibits HSCs activation. In a previous study, the protein CssPLA2 was expressed in insoluble inclusion bodies. Therefore, it's necessary to express CssPLA2 in water-soluble form and determine whether the enzymatic activity of CssPLA2 or cell signalling pathways is involved in liver fibrosis caused by clonorchiasis...
March 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28302092/erratum-to-spectrum-and-frequencies-of-brca1-2-mutations-in-bulgarian-high-risk-breast-cancer-patients
#9
Rumyana Ivanova Dodova, Atanaska Velichkova Mitkova, Daniela Rosenova Dacheva, Lina Basam Hadjo, Alexandrina Ivanova Vlahova, Margarita Stoyanova Taushanova-Hadjieva, Spartak Stoyanov Valev, Marija Mitko Caulevska, Stanislava Dimitrova Popova, Ivan Emilov Popov, Tihomir Iliichev Dikov, Theophil Angelov Sedloev, Atanas Stefanov Ionkov, Konstanta Velinova Timcheva, Svetlana Liubomirova Christova, Ivo Marinov Kremensky, Vanio Ivanov Mitev, Radka Petrova Kaneva
No abstract text is available yet for this article.
March 16, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28299766/increased-level-of-c-kit-in-semen-of-infertile-patients-with-varicocele
#10
Guorong Jin, Jianrong Liu, Qin Qin, Songdan Gao, Fang Zhang, Yuehong Ma, Caiyun Ding, Lina Dong, Haizhen Yin, Yimin Wang
PURPOSE: Varicocele is the most common risk factor for male infertility, however, not all males with varicocele experience infertility. In fact, most patients with varicocele have normal spermatogenesis. The molecular mechanism of varicocele-associated infertility is yet to be completely understood. The aim of this study is to assess the association of a number of fertility regulatory factors on varicocele associated infertility and to throw light on the mechanism of varicocele-associated infertility...
March 16, 2017: Urology Journal
https://www.readbyqxmd.com/read/28299640/the-role-of-transplanted-visceral-fat-from-the-long-lived-growth-hormone-receptor-knockout-mice-on-insulin-signaling
#11
Mohammed T Bennis, Augusto Schneider, Berta Victoria, Andrew Do, Denise S Wiesenborn, Lina Spinel, Adam Gesing, John J Kopchick, Shadab A Siddiqi, Michal M Masternak
Growth hormone receptor knockout mice (GHRKO) are characterized by high insulin sensitivity and extended lifespan. Interestingly, the secretory activity of visceral fat in GHRKO mice is altered, stimulating whole body insulin sensitivity. In this study, we transplanted normal (N) mice with visceral fat pads from GHRKO or N mice to determine the role of visceral fat on the insulin signaling. We found that the transplant of visceral fat from GHRKO mice to N mice (N-GHRKO) improved whole body insulin sensitivity when comparing with sham-operated mice (N-S) and with mice that received visceral fat from N mice (N-N)...
February 2017: Geroscience
https://www.readbyqxmd.com/read/28299283/lenvatinib-for-anaplastic-thyroid-cancer
#12
Makoto Tahara, Naomi Kiyota, Tomoko Yamazaki, Naoko Chayahara, Kenji Nakano, Lina Inagaki, Kazuhisa Toda, Tomohiro Enokida, Hironobu Minami, Yoshinori Imamura, Tatsuya Sasaki, Takuya Suzuki, Katsuki Fujino, Corina E Dutcus, Shunji Takahashi
BACKGROUND: Lenvatinib has been approved by regulatory agencies in Japan, the United States, and the European Union for treatment of radioiodine-refractory differentiated thyroid cancer (RR-DTC). Thyroid cancer, however, is a clinically diverse disease that includes anaplastic thyroid cancer (ATC), the subtype associated with the highest lethality. Effective therapy for ATC is an unmet need. PATIENTS AND METHODS: This phase 2, single-arm, open-label study in patients with thyroid cancer, including ATC, RR-DTC, and medullary thyroid cancer was conducted from 3 September 2012 to 9 July 2015...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28299231/chronic-osteoporotic-pain-in-mice-cutaneous-and-deep-musculoskeletal-pain-are-partially-independent-of-bone-resorption-and-differentially-sensitive-to-pharmacological-interventions
#13
Miyako Suzuki, Magali Millecamps, Lina Naso, Seiji Ohtori, Chisato Mori, Laura S Stone
Although the pathological changes in osteoporotic bones are well established, the characterization of the osteoporotic pain and its appropriate treatment are not fully elucidated. We investigated the behavioral signs of cutaneous and deep musculoskeletal pain and physical function; time-dependent changes in bone mineral density (BMD) and the emergence of the behavioral phenotype; and the effects of pharmacological interventions having different mechanisms of action (chronic intraperitoneal administration of pamidronate [0...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28296235/the-circular-rna-cirs-7-promotes-app-and-bace1-degradation-in-an-nf-%C3%AE%C2%BAb-dependent-manner
#14
Zhemin Shi, Ting Chen, Qingbin Yao, Lina Zheng, Zhen Zhang, Jingzhao Wang, Zhimei Hu, Hongmei Cui, Yawei Han, Xiaohui Han, Kun Zhang, Wei Hong
The aberrant accumulation of β-amyloid peptide (Aβ) in the brain is a key feature of Alzheimer's disease (AD), and enhanced cleavage of β-amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) has a major causative role in AD. Despite their prominence in AD pathogenesis, the regulation of BACE1 and APP is incompletely understood. In this study, we report that the circular RNA circular RNA sponge for miR-7 (ciRS-7) has an important role in regulating BACE1 and APP protein levels. Previous studies have shown that ciRS-7, which is highly expressed in the human brain, is down-regulated in the brain of people with AD but the relevance of this finding was not clear...
March 13, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28296001/circulating-long-non-coding-rnas-nron-and-mhrt-as-novel-predictive-biomarkers-of-heart-failure
#15
Lina Xuan, Lihua Sun, Ying Zhang, Yuechao Huang, Yan Hou, Qingqi Li, Ying Guo, Bingbing Feng, Lina Cui, Xiaoxue Wang, Zhiguo Wang, Ye Tian, Bo Yu, Shu Wang, Chaoqian Xu, Mingyu Zhang, Zhimin Du, Yanjie Lu, Bao Feng Yang
This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for heart failure (HF). We measured the circulating levels of 13 individual lncRNAs which are known to be relevant to cardiovascular disease in the plasma samples from 72 HF patients and 60 non-HF control participants using real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) methods. We found that out of the 13 lncRNAs tested, non-coding repressor of NFAT (NRON) and myosin heavy-chain-associated RNA transcripts (MHRT) had significantly higher plasma levels in HF than in non-HF subjects: 3...
March 14, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28293803/altered-resting-state-functional-connectivity-of-the-cerebellum-in-schizophrenia
#16
Chuanjun Zhuo, Chunli Wang, Lina Wang, Xinyu Guo, Qingying Xu, Yanyan Liu, Jiajia Zhu
Structural and functional abnormalities of the cerebellum in schizophrenia have been reported. Most previous studies investigating resting-state functional connectivity (rsFC) have relied on a priori restrictions on seed regions or specific networks, which may bias observations. In this study, we aimed to elicit the connectivity alterations of the cerebellum in schizophrenia in a hypothesis-free approach. Ninety-five schizophrenia patients and 93 sex- and age-matched healthy controls underwent resting-state functional magnetic resonance imaging (fMRI)...
March 14, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28293476/evaluating-the-levels-of-csf-and-serum-factors-in-als
#17
Jie Guo, Xuan Yang, Lina Gao, Dawei Zang
OBJECTIVES: The aim of this study was to identify CSF and serum factors as biomarkers that may aid in distinguishing ALS patients from control subjects and predicting ALS progression as well as prognosis. METHODS: Serum and CSF samples from 105 patients with ALS and 56 control subjects were analyzed for 13 factors using ELISA. The revised ALS functional rating scale (ALSFRS-r) was used to evaluate the overall functional status of ALS patients, and we also followed up with ALS patients either by phone or with clinic visits for five years after enrollment in this study...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28293411/a-strange-manifestation-of-malaria-in-a-native-nigerian-boy
#18
Paola Magro, Ilaria Izzo, Barbara Saccani, Salvatore Casari, Silvio Caligaris, Lina Rachele Tomasoni, Alberto Matteelli, Annamaria Lombardi, Antonella Meini, Francesco Castelli
The protective role of Sickle Cell Trait (SCT) in malaria endemic areas has been proved, and prevalence of HbS gene in malaria endemic areas is high. Splenic infarction is a well-known complication of SCT, while the association with malaria is considered rare. A Nigerian boy was admitted to our ward after returning from his country of origin, for P. falciparum malaria. He underwent abdominal ultrasound for upper right abdominal pain, showing cholecystitis and multiple splenic lesions suggestive of abscesses...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28293065/the-combination-of-mbp-and-bcg-induced-dendritic-cell-maturation-through-tlr2-tlr4-promotes-th1-activation-in-vitro-and-vivo
#19
LiNa Jiang, GuoMu Liu, WeiHua Ni, NanNan Zhang, Jing Jie, Fei Xie, GuiXiang Tai
To explore whether TLR2/TLR4 could be involved in the maturation of dendritic cells and polarization of CD4(+) T cells induced by dendritic cells stimulated with MBP and BCG, in vitro and in vivo experiments using TLR2(-/-) or TLR4(-/-) mice were employed. MBP and BCG elevated CD80, CD86 and MHC class II expressed on dendritic cells and increased IL-12 protein, induced DC maturation, and indirectly promoted Th1 activation. Moreover, MBP and BCG upregulated costimulatory molecules on DCs in a TLR2- and TLR4-dependent manner...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28293043/treatment-of-post-transplantation-lymphoproliferative-disorders-after-kidney-transplant-with-rituximab-and-conversion-to-m-tor-inhibitor
#20
John Fredy Nieto-Rios, Sandra Milena Gómez de Los Ríos, Lina María Serna-Higuita, Catalina Ocampo-Kohn, Arbey Aristizabal-Alzate, Kenny Mauricio Gálvez-Cárdenas, Gustavo Adolfo Zuluaga-Valencia
BACKGROUND: Post-transplantation lymphoproliferative disorders are serious complications of organ transplantation which treatment is not yet standardized. OBJECTIVE: To describe the clinical response, overall and graft survival of patients in our center with this complication after kidney transplantation, which received rituximab as part of their treatment as well as conversion to m-TOR. METHODS: Retrospective study, which included patients, diagnosed with post-transplant lymphoproliferative disorders after kidney transplantation from January 2011 to July 2014...
December 30, 2016: Colombia Médica: CM
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