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https://www.readbyqxmd.com/read/28544814/optimization-of-liposomal-topotecan-for-use-in-treating-neuroblastoma
#1
Lina Chernov, Rebecca J Deyell, Malathi Anantha, Nancy Dos Santos, Roger Gilabert-Oriol, Marcel B Bally
The purpose of this work was to develop an optimized liposomal formulation of topotecan for use in the treatment of patients with neuroblastoma. Drug exposure time studies were used to determine that topotecan (Hycamtin) exhibited great cytotoxic activity against SK-N-SH, IMR-32 and LAN-1 neuroblastoma human cell lines. Sphingomyelin (SM)/cholesterol (Chol) and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)/Chol liposomes were prepared using extrusion methods and then loaded with topotecan by pH gradient and copper-drug complexation...
May 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28544445/morphology-and-structure-engineering-in-nanofiber-reactor-tubular-hierarchical-integrated-networks-composed-of-dual-phase-octahedral-comn2-o4-carbon-nanofibers-for-water-oxidation
#2
Han Zhu, Danni Yu, Songge Zhang, Jiawei Chen, Wenbo Wu, Meng Wan, Lina Wang, Ming Zhang, Mingliang Du
1D hollow nanostructures combine the advantages of enhanced surface-to-volume ratio, short transport lengths, and efficient 1D electron transport, which can provide more design ideas for the preparation of highly active oxygen evolution (OER) electrocatalysts. A unique architecture of dual-phase octahedral CoMn2 O4 /carbon hollow nanofibers has been prepared via a two-step heat-treatment process including preoxidation treatment and Ostwald ripening process. The hollow and porous structures provide interior void spaces, large exposed surfaces, and high contact areas between the nanofibers and electrolyte and the morphology can be engineered by adjusting the heating conditions...
May 22, 2017: Small
https://www.readbyqxmd.com/read/28543911/polymorphism-of-tlr5-rs5744174-is-associated-with-disease-progression-in-chinese-patients-with-chronic-hbv-infection
#3
Lina Cao, Tong Zhang, Junping Zhu, Aixin Li, Kai Zheng, Nan Zhang, Bin Su, Wei Xia, Hao Wu, Ning Li, Qiushui He
Toll-like receptors (TLRs) play a crucial role in innate and adaptive immunity, protecting the host from viral pathogens. Studies have implicated that TLR5 is associated with various diseases such as autoimmune and inflammation related diseases. However, little is known about the relationship between TLR5 and hepatitis B virus (HBV) infection. We studied the effect of TLR5 gene polymorphisms on susceptibility to and disease progression of chronic hepatitis B (CHB) infection in Chinese. Blood samples were taken from 636 patients with CHB, HBV-related liver cirrhosis (LC) or hepatocellular carcinoma (HCC) and 273 controls...
May 25, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28542664/-vertical-transmission-of-chikungunya-virus-infection-case-report
#4
Sara E Cardona-Correa, Lina María Castaño-Jaramillo, Augusto Quevedo-Vélez
Chikungunya virus infection is a disease transmitted by vectors, in which vertical transmission was described in years 2005-2006. An infection rate up to 49% in neonates born from mothers with active viremia during labor has been observed. Perinatal infection could results in serious complications and potential cognitive impairment. OBJECTIVE: To describe a newborn with Chikungunya virus infection secundary to vertical transmission. Clínical case: A female newborn is analyzed. She presented with fever and exanthema during her first week of life, elevation of transaminases and thrombocytopenia...
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28542636/influence-of-learning-styles-on-the-practical-performance-after-the-four-step-basic-life-support-training-approach-an-observational-cohort-study
#5
Hanna Schröder, Alexandra Henke, Lina Stieger, Stefan Beckers, Henning Biermann, Rolf Rossaint, Saša Sopka
BACKGROUND: Learning and training basic life support (BLS)-especially external chest compressions (ECC) within the BLS-algorithm-are essential resuscitation training for laypersons as well as for health care professionals. The objective of this study was to evaluate the influence of learning styles on the performance of BLS and to identify whether all types of learners are sufficiently addressed by Peyton's four-step approach for BLS training. METHODS: A study group of first-year medical students (n = 334) without previous medical knowledge was categorized according to learning styles using the German Lernstilinventar questionnaire based on Kolb's Learning Styles Inventory...
2017: PloS One
https://www.readbyqxmd.com/read/28539415/vitamin-d-supplementation-trials-aimed-at-reducing-mortality-have-much-higher-power-when-focusing-on-people-with-low-serum-25-hydroxyvitamin-d-concentrations
#6
Hermann Brenner, Lina Jansen, Kai-Uwe Saum, Bernd Holleczek, Ben Schöttker
Background: Evidence of an inverse association between serum vitamin D and mortality from epidemiological studies has prompted efforts to reduce mortality by vitamin D supplementation, either in targeted interventions for people with vitamin D insufficiency or deficiency, or in untargeted interventions regardless of baseline vitamin D status.Objective: We aimed to assess the expected impact of the 2 different approaches on effect sizes and power of intervention studies.Methods: Serum concentrations of 25-hydroxyvitamin D [25(OH)D] were measured in 9579 participants aged 50-75 y in the German Epidemiologische Studie zu Chancen der Verhütung, Früherkennung und optimierten Therapie chronischer Erkrankungen in der älteren Bevölkerung (ESTHER) study who were followed for mortality for a median of 12...
May 24, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28537263/evolutionary-dynamics-and-genomic-features-of-the-elizabethkingia-anophelis-2015-to-2016-wisconsin-outbreak-strain
#7
Amandine Perrin, Elise Larsonneur, Ainsley C Nicholson, David J Edwards, Kristin M Gundlach, Anne M Whitney, Christopher A Gulvik, Melissa E Bell, Olaya Rendueles, Jean Cury, Perrine Hugon, Dominique Clermont, Vincent Enouf, Vladimir Loparev, Phalasy Juieng, Timothy Monson, David Warshauer, Lina I Elbadawi, Maroya Spalding Walters, Matthew B Crist, Judith Noble-Wang, Gwen Borlaug, Eduardo P C Rocha, Alexis Criscuolo, Marie Touchon, Jeffrey P Davis, Kathryn E Holt, John R McQuiston, Sylvain Brisse
An atypically large outbreak of Elizabethkingia anophelis infections occurred in Wisconsin. Here we show that it was caused by a single strain with thirteen characteristic genomic regions. Strikingly, the outbreak isolates show an accelerated evolutionary rate and an atypical mutational spectrum. Six phylogenetic sub-clusters with distinctive temporal and geographic dynamics are revealed, and their last common ancestor existed approximately one year before the first recognized human infection. Unlike other E...
May 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28536779/the-association-between-microsatellite-instability-and-lymph-node-count-in-colorectal-cancer
#8
Alexander Arnold, Matthias Kloor, Lina Jansen, Jenny Chang-Claude, Hermann Brenner, Moritz von Winterfeld, Michael Hoffmeister, Hendrik Bläker
The number of lymph nodes retrieved from colorectal cancer (CRC) resection specimens is crucial for adequate diagnosis and therapy. Previous studies indicate that in addition to the extent of surgical resection and the quality of pathological lymph node examination, non-modifiable tumour parameters like microsatellite instability (MSI) are associated with higher lymph node count. In order to study the potential influence of MSI on lymph node count, we analysed a previously MSI-typed population of CRC patients (n = 1196) to determine the relationship between MSI and the frequency with which at least 12 lymph nodes were retrieved, as well as the mean and median number of retrieved lymph nodes...
May 23, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28536588/a-novel-wheat-c-bzip-gene-tabzip14-b-participates-in-salt-and-freezing-tolerance-in-transgenic-plants
#9
Lina Zhang, Lichao Zhang, Chuan Xia, Lifeng Gao, Chenyang Hao, Guangyao Zhao, Jizeng Jia, Xiuying Kong
The group C-bZIP transcription factors (TFs) are involved in diverse biological processes, such as the regulation of seed storage protein (SSP) production and the responses to pathogen challenge and abiotic stress. However, our knowledge of the abiotic functions of group C-bZIP genes in wheat remains limited. Here, we present the function of a novel TabZIP14-B gene in wheat. This gene belongs to the group C-bZIP TFs and contains six exons and five introns; three haplotypes were identified among accessions of tetraploid and hexaploid wheat...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28536097/dynamic-regulation-of-vegf-inducible-genes-by-an-erk-erg-p300-transcriptional-network
#10
Jason E Fish, Manuel Cantu Gutierrez, Lan T Dang, Nadiya Khyzha, Zhiqi Chen, Shawn Veitch, Henry S Cheng, Melvin Khor, Lina Antounians, Makon-Sébastien Njock, Emilie Boudreau, Alexander M Herman, Alexander M Rhyner, Oscar E Ruiz, George T Eisenhoffer, Alejandra Medina-Rivera, Michael D Wilson, Joshua D Wythe
The transcriptional pathways activated downstream of Vascular Endothelial Growth Factor (VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the signals responsible for induction of the Notch ligand, Delta-Like 4 (DLL4) in endothelial cells we find that activation of the MAPK/ERK pathway mirrors the rapid and dynamic induction of DLL4 transcription and that this pathway is required for DLL4 expression. Furthermore, VEGF/ERK signaling induces phosphorylation and activation of the ETS transcription factor ERG, a prerequisite for DLL4 induction...
May 23, 2017: Development
https://www.readbyqxmd.com/read/28536072/characterization-of-astrovirus-associated-gastroenteritis-in-hospitalized-children-under-five-years-of-age
#11
Hassan Zaraket, Hadi Abou-El-Hassan, Khalil Kreidieh, Nadia Soudani, Zainab Ali, Moza Hammadi, Lina Reslan, Soha Ghanem, Farah Hajar, Adlette Inati, Mariam Rajab, Hassan Fakhouri, Bassam Ghanem, Ghassan Baasiri, Nada M Melhem, Ghassan Dbaibo
PURPOSE: The aim of this study was to determine the incidence and genetic diversity of astrovirus (AstV) detected in children hospitalized for gastroenteritis (GE). METHODS: A multi-center, hospital-based surveillance study was conducted across Lebanon to investigate the incidence of AstV among diarrheal hospitalizations. Viral RNA was extracted from stool samples collected between 2011 and 2013 from children, below the age of 5years, hospitalized for GE at six medical centers across Lebanon...
May 20, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28535989/slow-release-of-etoposide-from-dextran-conjugation-shifts-etoposide-activity-from-cytotoxicity-to-differentiation-a-promising-tool-for-dosage-control-in-anticancer-metronomic-therapy
#12
Milena De Nicola, Emanuele Bruni, Enrico Traversa, Lina Ghibelli
Drug conjugation, improving drug stability, solubility and body permanence, allow achieving impressive results in tumor control. Here, we show that conjugation may provide a straightforward method to administer drugs by the emerging anticancer metronomic approach, presently consisting of low, repeated doses of cytotoxic drugs used in traditional chemotherapy, thus reducing toxicity without reducing efficiency; however, low dose maintenance in tumor sites is difficult. We show that conjugating the antitumor drug etoposide to dextran via pH-sensitive bond produces slow releasing, apoptosis-proficient conjugates rapidly internalized into acidic lysosomes; importantly, release of active etoposide requires cell internalization and acidic pH...
May 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28535968/abnormal-distribution-of-distinct-lymphocyte-subsets-in-children-with-wiskott-aldrich-syndrome
#13
Lina Zhou, Wenyan Li, Xuan Zhang, Dawei Liu, Yuan Ding, Rongxin Dai, Xiaodong Zhao
Wiskott-Aldrich syndrome (WAS) is a severe and rare primary immunodeficiency. Several studies show that WAS protein (WASp) plays a key role in the function of certain lymphocyte subsets. So far, no study has described distinct immunophenotypic abnormalities associated with WAS; thus the prognostic significance of any such abnormalities is unclear. This study examined many differences in the percentage/absolute numbers of distinct lymphocyte subsets in 20 WAS patients and 20 age/sex-matched healthy controls, and analyzed the association between these abnormalities and clinical disease scores...
May 20, 2017: Human Immunology
https://www.readbyqxmd.com/read/28534943/bu-fei-decoction-attenuates-the-tumor-associated-macrophage-stimulated-proliferation-migration-invasion-and-immunosuppression-of-non-small-cell-lung-cancer-partially-via-il-10-and-pd-l1-regulation
#14
Lina Pang, Shuyan Han, Yanna Jiao, Shantong Jiang, Xiran He, Pingping Li
Macrophages play a pivotal role in tumor microenvironment. Bu-Fei Decoction (BFD) is a classical formula of traditional Chinese medicine (TCM) to alleviate lung cancer related symptoms, whether it has antitumor effect or could influence cancer microenvironment deserves further study. The aim of the present study was to examine the antitumor effect of BFD on non-small cell lung cancer (NSCLC), and to investigate the underlying mechanisms through tumor associated macrophages (TAMs). M2-polarized TAMs were induced by Phorbol 12-myristate 13-acetate (PMA) and interleukin 4 (IL-4)...
May 19, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28534939/mir%C3%A2-181b%C3%A2-5p-mediates-tgf%C3%A2-%C3%AE-1-induced-epithelial-to-mesenchymal-transition-in-non-small-cell-lung-cancer-stem-like-cells-derived-from-lung-adenocarcinoma-a549-cells
#15
Xuetao Li, Jing Han, Haizhen Zhu, Lina Peng, Zhengtang Chen
The ability of non-small cell lung cancer (NSCLC) cells to invade and metastasize is associated with epithelial-to-mesenchymal transition (EMT). The process of EMT is, at least in part, regulated by microRNAs. However, it is unknown whether microRNAs regulate EMT in cancer stem-like cells (CSLCs), or which microRNAs are involved. In the present study, we compared microRNA expression in A549 cells, TGF‑β1-treated A549 cells, CSLCs characterized by the CD133+/CD326+ phenotype, and TGF‑β1-treated CSLCs. We found that miR‑181b‑5p expression was upregulated by TGF‑β1...
May 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28533553/24%C3%A2-h-accelerometry-in-epidemiological-studies-automated-detection-of-non-wear-time-in-comparison-to-diary-information
#16
Lina Jaeschke, Agnes Luzak, Astrid Steinbrecher, Stephanie Jeran, Maike Ferland, Birgit Linkohr, Holger Schulz, Tobias Pischon
Estimation of physical activity using 24 h-accelerometry requires detection of accelerometer non-wear time (NWT). It is common practice to define NWT as periods >60 minutes of consecutive zero-accelerations, but this algorithm was originally developed for waking hours only and its applicability to 24 h-accelerometry is unclear. We investigated sensitivity and specificity of different algorithms to detect NWT in 24 h-accelerometry compared to diary in 47 ActivE and 559 KORA participants. NWT was determined with algorithms >60, >90, >120, >150, or >180 minutes of consecutive zero-counts...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28533191/mir-34a-knockout-attenuates-cognitive-deficits-in-app-ps1-mice-through-inhibition-of-the-amyloidogenic-processing-of-app
#17
Chongdong Jian, Mengru Lu, Zhao Zhang, Long Liu, Xianfeng Li, Fang Huang, Ning Xu, Lina Qin, Qian Zhang, Donghua Zou
The noncoding miRNA-34a (miR-34a) is involved in Alzheimer's disease (AD) pathologenesis and shows potential for application as a biomarker for early diagnosis and intervention. Here, we established miR-34a knockout mice in an APP/PS1 background (APP/PS1-miR-34a KO mice) by crossbreeding miR-34a(-/-) mice with APP/PS1 mice. We then investigated cognitive impairment and related pathologies. The results showed that the level of miR-34a was increased at about 6months in APP/PS1 mice, consistent with the increase in amyloid β (Aβ), and cognitive function was significantly improved in mice when miR-34a was knocked out in 9-month-old and 12-month-old mice, indicating that miR-34a is a potential candidate for determining the progression of AD...
May 19, 2017: Life Sciences
https://www.readbyqxmd.com/read/28533065/co-overexpression-of-response-regulator-genes-slr1037-and-sll0039-improves-tolerance-of-synechocystis-sp-pcc-6803-to-1-butanol
#18
Xinyan Gao, Tao Sun, Lina Wu, Lei Chen, Weiwen Zhang
In this study, two response regulator (RR) encoding genes slr1037 as well as sll0039 were co-overexpressed in Synechocystis sp. PCC 6803 by metabolic engineering and the 1-butanol tolerance was successfully improved by 133%. Aiming to explore the possible mechanisms for the enhancing 1-butanol tolerance, a quantitative iTRAQ-LC-MS/MS proteomics approach was then employed, identifying 216 up-regulated and 99 down-regulated proteins compared to wild type after 1-butanol treatment. This study mapped the potential target genes regulated by Slr1037 and Sll0039 and demonstrated the feasibility of engineering response regulators for modifying the biofuel tolerance in cyanobacteria...
May 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28532540/-ocular-metastasis-in-lung-cancer-a-retrospective-analysis-in-a-single-chinese-hospital-and-literature-review
#19
Yan Xu, Yiduo Sun, Jing Zhao, Minjiang Chen, Lina Jiangde, Longyun Li, Wei Zhong, Mengzhao Wang
BACKGROUND: Eye is a rare site of lung cancer metastasis, and ocular metastasis is one of the largest challenges to cancer patients' quality of life (QOL). Here we present our experience on ocular metastasis of lung cancer and review relevant literature in an attempt to investigate the clinical features, treatment, and prognosis of these tumors. METHODS: The records of 9 patients with ocular metastasis of lung cancer treated at our hospital were analyzed. A literature review identified 42 cases reported in the last 10 years and their medical records were retrospectively estimated...
May 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28531894/evaluation-of-absolute-serum-creatinine-changes-in-staging-of-cirrhosis-induced-acute-renal-injury-and-its-association-with-long-term-outcomes
#20
Fangfang Zhou, Qun Luo, Lina Han, Huadong Yan, Wenhong Zhou, Zemin Wang, Yumei Li
BACKGROUND/AIMS: To assess the prognostic accuracy of absolute serum creatinine (sCr) changes ('Delta-sCr') on the long-term outcomes in cirrhotic patients, and evaluate the performance of the 'Delta-sCr' approach to stage acute kidney injury (AKI), compared with the Kidney Disease Improving Global Outcomes (KDIGO) criteria. METHODS: We conducted a retrospective analysis of 333 hospitalized patients. We classified AKI stages using two methods: 1) KDIGO AKI criteria; 2) 'Delta-sCr' system, defined by the difference between the baseline and the peak sCr value during the hospitalization...
May 25, 2017: Kidney & Blood Pressure Research
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