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https://www.readbyqxmd.com/read/29222296/what-are-the-current-treatment-approaches-for-patients-with-polycythemia-vera-and-essential-thrombocythemia
#1
REVIEW
Alessandro M Vannucchi, Paola Guglielmelli
Polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloproliferative neoplasms that are characterized by thrombohemorrhagic complications, symptom burden, and impaired survival mainly due to thrombosis, progression to myelofibrosis, and transformation to acute leukemia. In this manuscript, we will review the most recent changes in diagnostic criteria, the improvements in risk stratification, and the "state of the art" in the daily management of these disorders. The role of conventional therapies and novel agents, interferon α and the JAK2 inhibitor ruxolitinib, is critically discussed based on the results of a few basic randomized clinical studies...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221302/the-society-for-translational-medicine-clinical-practice-guidelines-for-mechanical-ventilation-management-for-patients-undergoing-lobectomy
#2
REVIEW
Shugeng Gao, Zhongheng Zhang, Alessandro Brunelli, Chang Chen, Chun Chen, Gang Chen, Haiquan Chen, Jin-Shing Chen, Stephen Cassivi, Ying Chai, John B Downs, Wentao Fang, Xiangning Fu, Martínez I Garutti, Jianxing He, Jie He, Jian Hu, Yunchao Huang, Gening Jiang, Hongjing Jiang, Zhongmin Jiang, Danqing Li, Gaofeng Li, Hui Li, Qiang Li, Xiaofei Li, Yin Li, Zhijun Li, Chia-Chuan Liu, Deruo Liu, Lunxu Liu, Yongyi Liu, Haitao Ma, Weimin Mao, Yousheng Mao, Juwei Mou, Calvin Sze Hang Ng, René H Petersen, Guibin Qiao, Gaetano Rocco, Erico Ruffini, Lijie Tan, Qunyou Tan, Tang Tong, Haidong Wang, Qun Wang, Ruwen Wang, Shumin Wang, Deyao Xie, Qi Xue, Tao Xue, Lin Xu, Shidong Xu, Songtao Xu, Tiansheng Yan, Fenglei Yu, Zhentao Yu, Chunfang Zhang, Lanjun Zhang, Tao Zhang, Xun Zhang, Xiaojing Zhao, Xuewei Zhao, Xiuyi Zhi, Qinghua Zhou
Patients undergoing lobectomy are at significantly increased risk of lung injury. One-lung ventilation is the most commonly used technique to maintain ventilation and oxygenation during the operation. It is a challenge to choose an appropriate mechanical ventilation strategy to minimize the lung injury and other adverse clinical outcomes. In order to understand the available evidence, a systematic review was conducted including the following topics: (I) protective ventilation (PV); (II) mode of mechanical ventilation [e...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221027/development-of-a-unimorph-deformable-mirror-with-water-cooling
#3
Zhengxiong Zhu, Yan Li, Junjie Chen, Jianqiang Ma, Jiaru Chu
Deformable mirror (DM) used for intracavity compensation in high-power lasers should be able to withstand very high laser intensity. This paper proposes a water-cooled unimorph DM which can withstand the laser power up to 10 kW in thermal simulation. The proposed DM consists of an annular PZT layer and a circular Si layer which are glued together with edge clamped. All the 32 piezoelectric actuators are distributed around the correction area and on the front side of the DM. The cooling water flows through the back side of the DM and cools the mirror directly...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29218727/gabaa-and-gabab-receptor-subunit-localisation-on-neurochemically-identified-neurons-of-the-human-subthalamic-nucleus
#4
Xi Hua Wu, Jennifer Junru Song, Richard Lewis Maxwell Faull, Henry John Waldvogel
The subthalamic nucleus (STN) is a critical excitatory signalling centre within the basal ganglia circuitry. The activity of subthalamic neurons is tightly controlled by upstream inhibitory signalling centres in the basal ganglia. In this study, we used immunohistochemical techniques to firstly, visualise and quantify the STN neurochemical organisation based on neuronal markers including parvalbumin (PV), calretinin (CR), SMI-32 and GAD65/67 . Secondly, we characterised the detailed regional, cellular and subcellular expression of GABAA (α1 , α2 , α3 , β2/3 and γ2 ) and GABAB (R1 and R2) receptor subunits within the normal human STN...
December 8, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29218377/genetic-mapping-of-a-major-gene-in-triticale-conferring-resistance-to-bacterial-leaf-streak
#5
Aimin Wen, Malini Jayawardana, Jason Fiedler, Suraj Sapkota, Gongjun Shi, Zhao Peng, Sanzhen Liu, Frank F White, Adam J Bogdanove, Xuehui Li, Zhaohui Liu
A major gene conferring resistance to bacterial leaf streak was mapped to chromosome 5R in triticale. Bacterial leaf streak (BLS), caused by Xanthomonas translucens pv. undulosa (Xtu), is an important disease of wheat and triticale around the world. Although resistance to BLS is limited in wheat, several triticale accessions have high levels of resistance. To characterize the genetic basis of this resistance, we developed triticale mapping populations using a resistant accession (Siskiyou) and two susceptible accessions (UC38 and Villax St...
December 7, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29217833/calr-mutational-status-identifies-different-disease-subtypes-of-essential-thrombocythemia-showing-distinct-expression-profiles
#6
Roberta Zini, Paola Guglielmelli, Daniela Pietra, Elisa Rumi, Chiara Rossi, Sebastiano Rontauroli, Elena Genovese, Tiziana Fanelli, Laura Calabresi, Elisa Bianchi, Simona Salati, Mario Cazzola, Enrico Tagliafico, Alessandro M Vannucchi, Rossella Manfredini
Polycythemia vera (PV) and essential thrombocythemia (ET) are Philadelphia-negative myeloproliferative neoplasms (MPNs) characterized by erythrocytosis and thrombocytosis, respectively. Approximately 95% of PV and 50-70% of ET patients harbor the V617F mutation in the exon 14 of JAK2 gene, while about 20-30% of ET patients carry CALRins5 or CALRdel52 mutations. These ET CALR-mutated subjects show higher platelet count and lower thrombotic risk compared to JAK2-mutated patients. Here, we showed that CALR-mutated and JAK2V617F-positive CD34+ cells display different gene and miRNA expression profiles...
December 8, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/29217244/intraoperative-transesophageal-and-postoperative-transthoracic-echocardiographic-evaluation-of-a-mechanical-heart-valve-prosthesis-implanted-at-aortic-position
#7
Saravana Babu, Rupa Sreedhar, Shrinivas V Gadhinglajkar, Prasanta Kumar Dash, Subin Sukesan, Vivek Pillai, Varghese T Panicker, Lovhale Pravin Shriram, Neelam Aggarwal
OBJECTIVE: The aims of this study were to evaluate the intraoperative transesophageal echocardiographic (iTEE) characteristics and Doppler flow profile of aortic Chitra heart valve prosthesis (CHVP) under stable hemodynamic and loading conditions, and to compare and correlate the iTEE data with the postoperative transthoracic echocardiography (TTE) data obtained at 48 hours (TTE1) and 3 months (TTE2) after the surgery. DESIGN: Prospective, observational study. SETTING: University-level tertiary referral hospital...
September 6, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29215107/%C3%AE-carotene-bioaccessibility-from-biofortified-maize-zea-mays-is-related-to-its-density-and-is-negatively-influenced-by-lutein-and-zeaxanthin
#8
Nivedita Dube, Purna Chandra Mashurabad, Firoz Hossain, Raghu Pullakhandam, Longvah Thingnganing, Dinesh Kumar Bharatraj
Biofortification of maize with provitamin A (pro-VA) carotenoids has been successful, but the bioavailability of carotenoids needs to be explored. In the present study, we investigated the carotenoid content, micellarization and intestinal cell uptake of carotenoids from 10 maize hybrids [normal maize, quality protein maize (QPM), pro-VA carotenoid and double biofortified QPM + pro-VA maize hybrids] using a simulated in vitro digestion/Caco-2 cell model. The pro-VA carotenoid content of biofortified maize hybrids is 2-10 fold higher compared to that of normal maize...
December 7, 2017: Food & Function
https://www.readbyqxmd.com/read/29213152/serological-and-molecular-analysis-of-parvovirus-b19-infection-in-mayan-women-with-systemic-lupus-erythematosus-in-mexico
#9
Guillermo Valencia Pacheco, Yumi E Nakazawa Ueji, Edwin A Rodríguez Dzul, Angélica V Angulo Ramírez, Ricardo F López Villanueva, Irma G Quintal Ortiz, Elsy P Rosado Paredes
Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that mainly affects women, characterized by the production of autoantibodies. Its causal agent is unknown, but the combination of environmental, hormonal and genetic factors may favor the development of the disease. Parvovirus B19 has been associated with the development of SLE, since it induces the production of anti-single stranded DNA antibodies. It is unknown whether PV-B19 infection is an environmental factor that trigger or reactivate SLE in the Mexican Mayan population...
September 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29212965/effects-of-ezetimibe-statin-combination-therapy-on-coronary-atherosclerosis-in-acute-coronary-syndrome
#10
Kiyoshi Hibi, Shinjo Sonoda, Masanori Kawasaki, Yutaka Otsuji, Toyoaki Murohara, Hideki Ishii, Katsuhiko Sato, Ryoji Koshida, Yukio Ozaki, Masataka Sata, Yoshihiro Morino, Tadashi Miyamoto, Tetsuya Amano, Satoshi Morita, Ken Kozuma, Kazuo Kimura, Hisayoshi Fujiwara
BACKGROUND: The results of previous clinical trials on the effects of ezetimibe-statin combination therapy on atherosclerosis are inconsistent, and the anti-atherosclerotic effect of ezetimibe remains controversial.Methods and Results:We conducted a prospective, randomized open-label study at 10 centers. One hundred and twenty-eight statin-naïve patients with acute coronary syndrome (ACS) undergoing intravascular ultrasound (IVUS)-guided percutaneous coronary intervention were randomized to receive either 2 mg/day pitavastatin plus 10 mg/day ezetimibe, or 2 mg/day pitavastatin...
December 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29212703/diagnostic-assay-development-for-poliovirus-eradication
#11
Nancy Gerloff, Hong Sun, Mark Mandelbaum, Chelsea Maher, W Allan Nix, Sohail Zaidi, Shahzad Shaukat, Lerato Seakamela, Uma P Nalavade, Deepa K Sharma, M Steven Oberste, Everardo Vega
With poliovirus eradication nearing, few pockets of active wild poliovirus (WPV) transmission remain in the world. Intratypic differentiation (ITD) plays a crucial part in laboratory surveillance as the molecular detection method that can identify and distinguish wild and vaccine-like polioviruses isolated from acute flaccid paralysis cases or environmental sources. The need to detect new variants of WPV serotype 1 (WPV1), and the containment of all serotype 2 polioviruses (PV2) in 2015 required changes to the previous version of the method...
December 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29212672/cardiovascular-response-to-prescribed-detraining-among-recreational-athletes
#12
Charles Richard Pedlar, Marcel G Brown, Robert E Shave, James M Otto, Aimee Drane, Jennifer Michaud-Finch, Miranda Contursi, Meagan M Wasfy, Adolph Hutter, Michael H Picard, Gregory D Lewis, Aaron L Baggish
Exercise-induced cardiac remodeling (EICR) and the attendant myocardial adaptations characteristic of the athlete's heart may regress during periods of exercise reduction or abstinence. The time course and mechanisms underlying this reverse remodeling, specifically the impact of concomitant plasma volume (PV) contraction on cardiac chamber size, remain incompletely understood. We therefore studied recreational runners (n=21, aged 34 ± 7 years; 48% male) who completed an 18-week training program (~7 h.w-1) culminating in the 2016 Boston Marathon after which total exercise exposure was confined to <2 h...
December 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29211985/the-rna-binding-site-of-poliovirus-3c-protein-doubles-as-a-phosphoinositide-binding-domain
#13
Djoshkun Shengjuler, Yan Mei Chan, Simou Sun, Ibrahim M Moustafa, Zhen-Lu Li, David W Gohara, Matthias Buck, Paul S Cremer, David D Boehr, Craig E Cameron
Some viruses use phosphatidylinositol phosphate (PIP) to mark membranes used for genome replication or virion assembly. PIP-binding motifs of cellular proteins do not exist in viral proteins. Molecular-docking simulations revealed a putative site of PIP binding to poliovirus (PV) 3C protein that was validated using nuclear magnetic resonance spectroscopy. The PIP-binding site was located on a highly dynamic α helix, which also functions in RNA binding. Broad PIP-binding activity was observed in solution using a fluorescence polarization assay or in the context of a lipid bilayer using an on-chip, fluorescence assay...
December 5, 2017: Structure
https://www.readbyqxmd.com/read/29211755/comparison-between-the-diagnostic-validities-of-xpert-mtb-rif-and-interferon-%C3%AE-release-assays-for-tuberculous-pericarditis-using-pericardial-tissue
#14
Guocan Yu, Bo Ye, Da Chen, Fangming Zhong, Gang Chen, Jun Yang, Liliang Xu, Xudong Xu
BACKGROUND: This study aimed to assess the diagnostic performance of Xpert MTB/RIF for tuberculous pericarditis (TBP) using pericardial tissues. METHODS: The study involved 30 patients admitted with suspected TBP from January-December 2016; three patients were later excluded. The interferon-γ release assay (T-SPOT.TB) and the Xpert MTB/RIF test were performed using peripheral blood and pericardial tissues, respectively. TBP was confirmed using pericardial histopathology and a composite reference standard (CRS)...
2017: PloS One
https://www.readbyqxmd.com/read/29208907/connectivity-motifs-of-inhibitory-neurons-in-the-mouse-auditory-cortex
#15
Hysell V Oviedo
Connectivity determines the function of neural circuits and it is the gateway to behavioral output. The emergent properties of the Auditory Cortex (ACx) have been difficult to unravel partly due to our assumption that it is organized similarly to other sensory areas. But detailed investigations of its functional connectivity have begun to reveal significant differences from other cortical areas that perform different functions. Using Laser Scanning Photostimulation we previously discovered unique circuit features in the ACx...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208790/oral-manifestation-in-patients-diagnosed-with-dermatological-diseases
#16
Sanjay G Thete, Meena Kulkarni, Atul P Nikam, Tejashree Mantri, Dhiraj Umbare, Sushant Satdive, Dinraj Kulkarni
AIM: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India. MATERIALS AND METHODS: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014...
December 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29207142/screening-and-identification-of-differentially-expressed-serum-proteins-in-patients-with-vitiligo-using-two%C3%A2-dimensional-gel-electrophoresis-coupled-with-mass-spectrometry
#17
Yi-Lei Li, Rui-Qun Qi, Yang Yang, He-Xiao Wang, Hang-Hang Jiang, Zheng-Xiu Li, Bi-Huan Xiao, Song Zheng, Yu-Xiao Hong, Jiu-Hong Li, Hong-Duo Chen, Xing-Hua Gao
In the clinic, vitiligo is characterized by two stages: Stable and progressive. The pathogenesis of vitiligo is still not clear. Here, we identified serum markers of vitiligo by screening for differentially expressed proteins in patients with vitiligo compared to healthy individuals. Serum samples were collected from patients with vitiligo (n=10 for both the stable and progressive stages) and healthy individuals (n=10). Two‑dimensional gel electrophoresis followed by matrix‑assisted laser desorption/ionization time‑of‑flight mass spectrometry and western blotting were used to validate the differential expression of the proteins in the serum (n=20 each, at both stages for patients and healthy individuals)...
November 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29205559/bandgap-optimization-of-perovskite-semiconductors-for-photovoltaic-applications
#18
Zewen Xiao, Yuanyuan Zhou, Hideo Hosono, Toshio Kamiya, Nitin P Padture
Bandgap is the most important physical property for determining the potential of any semiconductors for photovoltaic (PV) applications. This minireview discusses the parameters affecting the bandgap of perovskite semiconductors that are being widely studied for PV applications, and the recent progress in the optimization of the bandgap of these materials. Perspectives are also provided for guiding future research in this area.
December 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29203892/metabolic-syndrome-and-smoking-are-associated-with-an-increased-risk-of-nocturia-in-male-patients-with-benign-prostatic-enlargement
#19
Cosimo De Nunzio, Aldo Brassetti, Flavia Proietti, Marianna Deroma, Francesco Esperto, Andrea Tubaro
BACKGROUND: To evaluate the relationship between cigarette smoking, metabolic syndrome (MetS) and nocturia in patients with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE). METHODS: From 2009 onward, a consecutive series of patients with LUTS/BPE were enrolled. Symptoms were assessed using the International Prostate Symptom Score (IPSS). Age, body mass index (BMI), smoker status, prostate volume (PV), prostate-specific antigen (PSA) levels, fasting glucose levels, triglyceride levels, and high-density lipoprotein levels were recorded...
December 4, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29201605/culture-free-detection-of-crop-pathogens-at-the-single-cell-level-by-micro-raman-spectroscopy
#20
Qinhua Gan, Xuetao Wang, Yun Wang, Zhenyu Xie, Yang Tian, Yandu Lu
The rapid and sensitive identification of invasive plant pathogens has important applications in biotechnology, plant quarantine, and food security. Current methods are far too time-consuming and need a pre-enrichment period ranging from hours to days. Here, a micro-Raman spectroscopy-based bioassay for culture-free pathogen quarantine inspection at the single cell level within 40 min is presented. The application of this approach can readily and specifically detect plant pathogens Burkholderia gladioli pv...
November 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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