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https://www.readbyqxmd.com/read/28090185/characteristics-and-outcomes-of-patients-with-anterior-circulation-intracranial-aneurysm-managed-with-clipping-in-hospital-sungai-buloh
#1
Ailani Ab Ghani, Saiful Azli Mat Nayan, Regunath Kandasamy, Azmin Kas Rosman, Abdul Rahman Izani Ghani
INTRODUCTION: The annual incidence of intracranial aneurysm in Malaysia is estimated to be 1.1-1.7 per 100,000 population based on a study done conducted in 1988. Since then, little epidemiological research has been conducted in Malaysia, and the real incidence is therefore probably unreported despite advancements in the diagnosis and treatment of this disorder. Intracranial aneurysm may be treated by microsurgical clipping or embolisation depending on its location and the surgeon's preference...
November 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28088807/posterior-versus-anterior-circulation-stroke-in-young-adults-a-comparative-study-of-stroke-aetiologies-and-risk-factors-in-stroke-among-young-fabry-patients-sifap1
#2
Bettina von Sarnowski, Ulf Schminke, Ulrike Grittner, Christian Tanislav, Tobias Böttcher, Michael G Hennerici, Turgut Tatlisumak, Jukka Putaala, Manfred Kaps, Franz Fazekas, Christian Enzinger, Arndt Rolfs, Christof Kessler
BACKGROUND: Although 20-30% of all strokes occur in the posterior circulation, few studies have explored the characteristics of patients with strokes in the posterior compared to the anterior circulation so far. Especially data on young patients is missing. METHODS: In this secondary analysis of data of the prospective multi-centre European sifap1 study that investigated stroke and transient ischemic attack (TIA) patients aged 18-55 years, we compared vascular risk factors, stroke aetiology, presence of white matter hyperintensities (WMH) and cerebral microbleeds (CMB) between patients with ischaemic posterior circulation stroke (PCS) and those having suffered from anterior circulation stroke (ACS) based on cerebral MRI...
January 14, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28088288/a-novel-mouse-model-of-staphylococcus-aureus-vascular-graft-infection-noninvasive-imaging-of-biofilm-development-in%C3%A2-vivo
#3
Hélène Van de Vyver, Philipp R Bovenkamp, Verena Hoerr, Katrin Schwegmann, Lorena Tuchscherr, Silke Niemann, Laura Kursawe, Christina Grosse, Annette Moter, Uwe Hansen, Ute Neugebauer, Michael T Kuhlmann, Georg Peters, Sven Hermann, Bettina Löffler
Staphylococcus aureus causes very serious infections of vascular grafts. Knowledge of the molecular mechanisms of this disease is largely lacking because of the absence of representable models. Therefore, the aim of this study was to set up a mouse model of vascular graft infections that closely mimics the human situation. A catheter was inserted into the right carotid artery of mice, which acted as a vascular graft. Mice were infected i.v. using 8 different S. aureus strains, and development of the infection was followed up...
January 4, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28087176/carotid-plaque-detection-improves-the-predictive-value-of-cha2ds2-vasc-score-in-patients-with-non-valvular-atrial-fibrillation-the-arapacis-study
#4
Stefania Basili, Lorenzo Loffredo, Daniele Pastori, Marco Proietti, Alessio Farcomeni, Anna Rita Vestri, Pasquale Pignatelli, Giovanni Davì, William R Hiatt, Gregory Y H Lip, Gino R Corazza, Francesco Perticone, Francesco Violi
BACKGROUND AND AIMS: Vascular disease (VD), as assessed by history of myocardial infarction or peripheral artery disease or aortic plaque, increases stroke risk in atrial fibrillation (AF), and is a component of risk assessment using the CHA2DS2-VASc score. We investigated if systemic atherosclerosis as detected by ultrasound carotid plaque (CP) could improve the predictive value of the CHA2DS2-VASc score. METHODS: We analysed data from the ARAPACIS study, an observational study including 2027 Italian patients with non-valvular AF, in whom CP was detected using Doppler Ultrasonography...
January 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28078510/relationship-between-framingham-risk-score-and-subclinical-atherosclerosis-in-carotid-plaques-an-in-vivo-study-using-multi-contrast-mri
#5
Feiyu Li, Xiaoying Wang
The assessment and management of early-stage atherosclerosis are important for the prevention of cardiovascular disease (CVD). In this study, we used multi-contrast magnetic resonance imaging (MRI) to investigate the carotid plaque feature in asymptomatic, at-risk subjects; we also evaluated the correlation between MRI findings and Framingham risk score (FRS). One hundred sixty-six asymptomatic individuals with risk factors for CVD underwent multi-contrast MRI. After the arterial morphology and plaque components were outlined, the differences in carotid plaque burden among the various risk categories were analyzed...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28077455/symptomatic-carotid-occlusion-is-frequently-associated-with-microembolization
#6
Ava L Liberman, Ali Zandieh, Caitlin Loomis, Jonathan M Raser-Schramm, Christina A Wilson, Jose Torres, Koto Ishida, Swaroop Pawar, Rebecca Davis, Michael T Mullen, Steven R Messé, Scott E Kasner, Brett L Cucchiara
BACKGROUND AND PURPOSE: Symptomatic carotid artery disease is associated with significant morbidity and mortality. The pathophysiologic mechanisms of cerebral ischemia among patients with carotid occlusion remain underexplored. METHODS: We conducted a prospective observational cohort study of patients hospitalized within 7 days of ischemic stroke or transient ischemic attack because of ≥50% carotid artery stenosis or occlusion. Transcranial Doppler emboli detection was performed in the middle cerebral artery ipsilateral to the symptomatic carotid...
January 11, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28076622/impact-of-surgeon-experience-during-carotid-endarterectomy-operation-and-effects-on-perioperative-outcomes
#7
Volkan Yüksel, Ahmet Coskun Ozdemir, Serhat Huseyin, Orkut Guclu, Fatma Nesrin Turan, Suat Canbaz
Objective: We evaluated the effect of surgeon experience on complication and mortality rates of carotid endarterectomy operation. Methods: Fifty-nine consecutive patients who underwent carotid endarterectomy between January 2013 and February 2016 were divided into two groups. Patients who had been operated by surgeons performing carotid endarterectomy for more than 10 years were allocated to group 1 (experienced surgeons; n=34). Group 2 (younger surgeons; n=25) consisted of patients operated by surgeons independently performing carotid endarterectomy for less than 2 years...
November 2016: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28074801/delirium-after-cardiac-surgery-a-pilot-study-from-a-single-tertiary-referral-center
#8
Ashok K Kumar, Aveek Jayant, V K Arya, Rohan Magoon, Ridhima Sharma
BACKGROUND: Advances in cardiac surgery has shifted paradigm of management to perioperative psychological illnesses. Delirium is a state of altered consciousness with easy distraction of thoughts. The pathophysiology of this complication is not clear, but identification of risk factors is important for positive postoperative outcomes. The goal of the present study was to prospectively identify the incidence, motoric subtypes, and risk factors associated with development of delirium in cardiac surgical patients admitted to postoperative cardiac intensive care, using a validated delirium monitoring instrument...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28073311/cervical-artery-tortuosity-is-associated-with-intracranial-aneurysm
#9
Paul-Emile Labeyrie, Florent Braud, Clément Gakuba, Thomas Gaberel, Cyrille Orset, Romain Goulay, Evelyne Emery, Patrick Courthéoux, Emmanuel Touzé
Background Intracranial aneurysms may be associated with an underlying arteriopathy, leading to arterial wall fragility. Arterial tortuosity is a major characteristic of some connective tissue disease. Aim To determine whether intracranial aneurysm is associated with an underlying arteriopathy. Methods Using a case-control design, from May 2012 to May 2013, we selected intracranial aneurysm cases and controls from consecutive patients who had conventional cerebral angiography in our center. Cases were patients with newly diagnosed intracranial aneurysm...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28073026/the-role-of-visfatin-in-atherosclerotic-peripheral-arterial-obstructive-disease
#10
Matthaios G Pitoulias, Lemonia Skoura, Apostolos G Pitoulias, Dimitris Chatzidimitriou, Apostolia Margariti, Minas Arsenakis, Georgios A Pitoulias
Visfatin is an adipokine molecule acting as an essential coenzyme in multiple cellular redox reactions. The increased serum levels of Visfatin have been correlated with metabolic syndrome and endothelial homeostasis. In this study we investigate the possible relationship of Visfatin serum levels with the severity and location of atherosclerotic peripheral arterial occlusive disease (PAOD). Study protocol included 45 consecutive PAOD and 20 Control patients with age >55years old. Definition of PAOD was based in Rutherord's classification (RC)...
January 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28070049/-common-factors-for-ischemic-cerebral-stroke-in-coronary-artery-bypass-grafting-in-patients-with-concomitant-carotid-and-coronary-artery-severe-stenosis
#11
Lei Huang, Feng Kuang, Zhonggui Shan, Yiquan Lai, Hongwei Guo
To analyze two common factors for perioperative ischemic stroke in patients with concomitant carotid and coronary artery severe stenosis and to improve the therapeutic effect.
 Methods: A total of 44 patients with multi-vessel coronary artery disease combined with carotid stenosis, who admitted to the Department of Cardiac Surgery, the First Affiliated Hospital of Xiamen University from 2008 to 2014, were enrolled in this study. Among them, 32 cases were male, 12 cases was female. All patients received coronary artery bypass grafting after treatment of neck diseases...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28069573/relations-between-aortic-stiffness-and-left-ventricular-mechanical-function-in-the-community
#12
Vanessa Bell, Elizabeth L McCabe, Martin G Larson, Jian Rong, Allison A Merz, Ewa Osypiuk, Birgitta T Lehman, Plamen Stantchev, Jayashri Aragam, Emelia J Benjamin, Naomi M Hamburg, Ramachandran S Vasan, Gary F Mitchell, Susan Cheng
BACKGROUND: Aortic stiffness impairs optimal ventricular-vascular coupling and left ventricular systolic function, particularly in the long axis. Left ventricular global longitudinal strain (GLS) has recently emerged as a sensitive measure of early cardiac dysfunction. In this study, we investigated the relation between aortic stiffness and GLS in a large community-based sample. METHODS AND RESULTS: In 2495 participants (age 39-90 years, 57% women) of the Framingham Offspring and Omni cohorts, free of cardiovascular disease, we performed tonometry to measure arterial hemodynamics and echocardiography to assess cardiac function...
January 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28069505/end-point-immobilization-of-heparin-on-plasma-treated-surface-of-electrospun-polycarbonate-urethane-vascular-graft
#13
Xuefeng Qiu, Benjamin Li-Ping Lee, Xinghai Ning, Niren Murthy, Nianguo Dong, Song Li
: Small-diameter synthetic vascular grafts have high failure rate due to primarily surface thrombogenicity, and effective surface chemical modification is critical to maintain the patency of the grafts. In this study, we engineered a small-diameter, elastic synthetic vascular graft with off-the-shelf availability and anti-thrombogenic activity. Polycarbonate-urethane (PCU), was electrospun to produce nanofibrous grafts that closely mimicked a native blood vessel in terms of structural and mechanical strength...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28066586/nanoparticle-mediated-arresten-gene-inhibits-neointimal-formation-of-vein-grafts-an-experimental-research
#14
Rong-Fei Wang, Qing-Yi Meng
BACKGROUND: Recently, we established a new rat model of venous arterialization by grafting the jugular vein into carotid arteries. In many respects, the morphological features of this murine vascular graft model resemble those of human venous bypass graft diseases. Using this model, we studied nanoparticles that mediated the arresten gene to inhibit the neointimal formation of vein grafts. METHODS: Thirty healthy Wistar female rats were randomly divided into three groups...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28065612/vertebral-tortuosity-index-in-patients-with-non-connective-tissue-disorder-related-aneurysm-disease
#15
F Virgilio, B Maurel, M Davis, G Hamilton, T M Mastracci
OBJECTIVE: The vertebral tortuosity index (VTI) predicts increased risk of acute aortic events in patients with known genetic aortopathies. This study describes the VTI in a cohort of patients with non-connective tissue disorder-related large aneurysms. METHODS: Hospital imaging records from July 2012 to March 2016 were interrogated to identify patients with aneurysmal disease who had undergone computed tomographic angiography that included imaging of vertebral arteries...
January 5, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28062495/therapeutic-targeting-of-rna-polymerase-i-with-the-small-molecule-cx-5461-for-prevention-of-arterial-injury-induced-neointimal-hyperplasia
#16
Qing Ye, Shu Pang, Wenjing Zhang, Xiaotong Guo, Jianli Wang, Yongtao Zhang, Yang Liu, Xiao Wu, Fan Jiang
OBJECTIVE: RNA polymerase I (Pol I)-dependent rRNA synthesis is a determinant factor in ribosome biogenesis and thus cell proliferation. The importance of dysregulated Pol I activity in cardiovascular disease, however, has not been recognized. Here, we tested the hypothesis that specific inhibition of Pol I might prevent arterial injury-induced neointimal hyperplasia. APPROACH AND RESULTS: CX-5461 is a novel selective Pol I inhibitor. Using this tool, we demonstrated that local inhibition of Pol I blocked balloon injury-induced neointima formation in rat carotid arteries in vivo...
January 5, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28062493/olfactomedin-2-regulates-smooth-muscle-phenotypic-modulation-and-vascular-remodeling-through-mediating-runt-related-transcription-factor-2-binding-to-serum-response-factor
#17
Ning Shi, Chen-Xiao Li, Xiao-Bing Cui, Stanislav I Tomarev, Shi-You Chen
OBJECTIVE: The objective of this study is to investigate the role and underlying mechanism of Olfactomedin 2 (Olfm2) in smooth muscle cell (SMC) phenotypic modulation and vascular remodeling. APPROACH AND RESULTS: Platelet-derived growth factor-BB induces Olfm2 expression in primary SMCs while modulating SMC phenotype as shown by the downregulation of SMC marker proteins. Knockdown of Olfm2 blocks platelet-derived growth factor-BB-induced SMC phenotypic modulation, proliferation, and migration...
January 5, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28062141/reduced-subclinical-carotid-vascular-disease-and-arterial-stiffness-in-vegetarian-men-the-carvos-study
#18
Julio Acosta-Navarro, Luiza Antoniazzi, Adriana Midori Oki, Maria Carlos Bonfim, Valeria Hong, Pedro Acosta-Cardenas, Celia Strunz, Eleonora Brunoro, Marcio Hiroshi Miname, Wilson Salgado Filho, Luiz Aparecido Bortolotto, Raul D Santos
BACKGROUND: Dietary habits play an important role in the development of atherosclerosis, the most important cause of morbidity and mortality in the world. The objective of this study was to verify if vegetarian (VEG) diet could be related a better profile of subclinical vascular disease evaluated by arterial stiffness and functional and structural properties of carotid arteries, compared to omnivorous (OMN) diet. METHODS: In this cross-sectional study, 44 VEG and 44 OMN apparently healthy men ≥35years of age, in order to not have confounding risk factors of subclinical atherosclerosis, were assessed for anthropometric data, blood pressure, blood lipids, glucose, C reactive protein (CRP), and arterial stiffness determined by carotid-femoral pulse wave velocity (PWV)...
December 20, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28061822/cardiovascular-risk-and-endothelial-function-in-people-living-with-hiv-aids-design-of-the-multi-site-longitudinal-endoafrica-study-in-the-western-cape-province-of-south-africa
#19
Hans Strijdom, Patrick De Boever, Gerhard Walzl, M Faadiel Essop, Tim S Nawrot, Ingrid Webster, Corli Westcott, Nyiko Mashele, Frans Everson, Stephanus T Malherbe, Kim Stanley, Harald H Kessler, Evelyn Stelzl, Nandu Goswami
BACKGROUND: There is growing evidence of an interaction between HIV-infection, anti-retroviral therapy (ART) and cardiovascular diseases (CVD). Epidemiological studies in Europe and North America have been observing a shift towards an increased incidence of coronary heart disease and acute myocardial infarctions in HIV-infected populations compared to the general population even after adjusting for traditional cardiovascular risk factors. Despite South Africa (and sub-Saharan Africa, SSA) being regarded as the epicentre of the global HIV epidemic, very little is known about the prevalence of cardiovascular risk factors and precursors of vascular disease in HIV-infected populations in this region...
January 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28060442/effects-of-6%C3%A2-months-of-aerobic-and-resistance-exercise-training-on-carotid-artery-intima-media-thickness-in-overweight-and-obese-older-women
#20
Jinkee Park, Hyuntea Park
AIM: We studied the effects of exercise on carotid intima-media thickness, luminal diameter, and flow velocity in overweight and obese older women, and the associations between carotid parameters changes and other variables. METHODS: A total of 41 overweight and obese older women (aged 65-77 years, fat mass percent ≥ 32%), who were divided into a control group (n = 20) and a supervised combined exercise group (n = 21). The 24-week combined exercise program (aerobic and resistance exercise) consisted of sessions 40-80 min in length 5 days per week under the supervision of an exercise specialist...
January 6, 2017: Geriatrics & Gerontology International
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