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https://www.readbyqxmd.com/read/28109164/assessment-of-biological-psychological-and-adherence-factors-in-the-prediction-of-step-down-treatment-for-patients-with-well-controlled-asthma
#1
Norihiro Saito, Akihito Kamata, Masamichi Itoga, Mami Tamaki, Hiroyuki Kayaba, Thomas Ritz
OBJECTIVES: Inhaled corticosteroids (ICS) and inhaled corticosteroids combined with long-acting beta2-agonist (ICS/LABA) are standard treatments for asthma. However, factors that might help reduce medication in well-controlled asthma are unknown. We classified problems of asthma patients into biological, psychological and adherence factors, and investigated factors associated with the indication and failure of a medication step-down treatment. METHODS: Two hundred twenty two well-controlled asthma patients receiving ICS or ICS/LABA were assessed for physical and psychiatric problems and followed up for one year from adjustment of their treatment step...
January 21, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28108941/factors-associated-with-emergency-department-useamong-veteran-psychiatric-patients
#2
Daniel M Blonigen, Kathryn S Macia, Xiaoyu Bi, Paola Suarez, Luisa Manfredi, Todd H Wagner
Frequent utilization of emergency department (ED) services contributes substantially to the cost of healthcare nationally and is often driven by psychiatric factors. Using national-level data from the Veterans Health Administration (VHA), the present study examined patient-level factors associated with ED use among veteran psychiatric patients. Veterans who had at least one ED visit with a psychiatric diagnosis in fiscal years 2011-2012 (n = 226,122) were identified in VHA administrative records. Andersen's behavioral model of healthcare utilization was used to identify need, enabling, and predisposing factors associated with frequency of ED use (primary outcome) in multivariate regression models...
January 21, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28108490/mri-shows-that-exhaustion-syndrome-due-to-chronic-occupational-stress-is-associated-with-partially-reversible-cerebral-changes
#3
I Savic, A Perski, W Osika
The present study investigates the cerebral effects of chronic occupational stress and its possible reversibility. Forty-eight patients with occupational exhaustion syndrome (29 women) and 80 controls (47 women) underwent structural magnetic resonance imaging (MRI) and neuropsychological testing. Forty-four participants (25 patients, 19 controls) also completed a second MRI scan after 1-2 years. Only patients received cognitive therapy. The stressed group at intake had reduced thickness in the right prefrontal cortex (PFC) and left superior temporal gyrus (STG), enlarged amygdala volumes, and reduced caudate volumes...
January 19, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28108394/unsmoothed-functional-mri-of-the-human-amygdala-and-bed-nucleus-of-the-stria-terminalis-during-processing-of-emotional-faces
#4
Ronald Sladky, Nicole Geissberger, Daniela M Pfabigan, Christoph Kraus, Martin Tik, Michael Woletz, Katharina Paul, Thomas Vanicek, Bastian Auer, Georg S Kranz, Claus Lamm, Rupert Lanzenberger, Christian Windischberger
Functional neuroimaging of the human amygdala has been of great interest to uncover the neural underpinnings of emotions, mood, motivation, social cognition, and decision making, as well as their dysfunction in psychiatric disorders. Yet, several factors limit in vivo imaging of amygdalar function, most importantly its location deep within the temporal lobe adjacent to air-filled cavities that cause magnetic field inhomogeneities entailing signal dropouts. Additionally, the amygdala and the extended amygdalar region consist of several substructures, which have been assigned different functions and have important implications for functional and effective connectivity studies...
January 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28108194/psychiatric-risk-in-unstably-housed-sexual-minority-women-relationship-between-sexual-and-racial-minority-status-and-human-immunodeficiency-virus-and-psychiatric-diagnoses
#5
Annesa Flentje, Martha Shumway, Lauren H Wong, Elise D Riley
BACKGROUND: Stress associated with minority statuses has been linked to mental health disorders. However, research conducted exclusively among impoverished women, a population known to be at risk for poor health owing to overlapping risks, is sparse. We sought to determine if homeless and unstably housed sexual minority (i.e., nonheterosexual) women were at greater psychiatric risk than their heterosexual counterparts. We also sought to determine if racial/ethnic minority and human immunodeficiency virus status contributed to psychiatric risks...
January 17, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28108057/bani-polymorphism-of-cytosolic-phospholipase-a2-gene-and-somatic-symptoms-in-medication-free-acute-depressed-patients
#6
Jane Pei-Chen Chang, Ta-Wei Guu, Yi-Chih Chen, Piotr Gałecki, Anna Walczewska, Kuan-Pin Su
Somatic symptoms are commonly seen in patients with major depressive disorder (MDD) and might be associated with inflammatory activation. Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression. This study investigated the effects of BanI polymorphism of cPLA2 gene and COX-2 rs4648308 genotypes on somatic symptoms and inflammatory marker in patients with MDD...
January 4, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28107388/factors-moderating-the-relationship-between-childhood-trauma-and-premorbid-adjustment-in-first-episode-schizophrenia
#7
S Kilian, J K Burns, S Seedat, L Asmal, B Chiliza, S Du Plessis, M R Olivier, M Kidd, R Emsley
Childhood trauma is a recognised risk factor for schizophrenia. It has been proposed that childhood trauma interferes with normal neurodevelopment, thereby establishing a biological vulnerability to schizophrenia. Poor premorbid adjustment is frequently a precursor to schizophrenia, and may be a manifestation of neurodevelopmental compromise. We investigated the relationship between childhood trauma and premorbid adjustment in 77 patients with first-episode schizophrenia spectrum disorders. We also investigated possible mediating roles for other selected risk factors in the relationship...
2017: PloS One
https://www.readbyqxmd.com/read/28107176/integrating-neurobiology-of-emotion-regulation-and-trauma-therapy-reflections-on-emdr-therapy
#8
Anabel González, Lucía Del Río-Casanova, Ania Justo-Alonso
Emotion dysregulation is a frequent feature in trauma-related disorders. Different kinds of emotion dysregulation seem to be linked to particular psychiatric conditions, and there is growing evidence of the association between neurobiological correlates and those dysregulation patterns. Nevertheless, many of the recent findings from the field of the neurobiology have not been translated into clinical practice and are insufficiently contemplated in trauma-oriented therapies. The aim of this article is to review recent developments in the field of emotion regulation connecting these issues with the practical implementation of psychotherapeutic procedures...
January 20, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28107037/health-service-utilisation-detection-rates-by-family-practitioners-and-management-of-patients-with-common-mental-disorders-in-french-family-practice
#9
Joanna Norton, Agnès Oude Engberink, Catherine Gandubert, Karen Ritchie, Anthony Mann, Michel David, Delphine Capdevielle
OBJECTIVE: Provide up-to-date detection rates for common mental disorders (CMD) and examine patient service-use since the Preferred Doctor scheme was introduced to France in 2005, with patients encouraged to register with and consult a family practitioner (FP) of their choice. METHODS: Study of 1133 consecutive patients consulting 38 FPs in the Montpellier region, replicating a study performed before the scheme. Patients in the waiting room completed the self-report Patient Health Questionnaire (PHQ) and Client Service-Receipt Inventory with questions on registration with a Preferred Doctor and doctor-shopping...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28106914/classification-of-childhood-onset-eating-disorders-a-latent-class-analysis
#10
Leora Pinhas, Dasha Nicholls, Ross D Crosby, Anne Morris, Richard M Lynn, Sloane Madden
This study tested the hypothesis that latent class analysis (LCA) would successfully classify eating disorder (ED) symptoms in children into categories that mapped onto DSM-5 diagnoses and that these categories would be consistent across countries. Childhood onset ED cases were ascertained through prospective active surveillance by the Australian Paediatric Surveillance Unit, the Canadian Paediatric Surveillance Program, and the British Paediatric Surveillance Unit for 36, 24, and 14 months, respectively. Pediatricians and child psychiatrists reported symptoms of any child aged ≤ 12 years with a newly diagnosed restrictive ED...
January 20, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28105280/glun2a-selective-pyridopyrimidinone-series-of-nmdar-positive-allosteric-modulators-with-an-improved-in-vivo-profile
#11
Elisia Villemure, Matthew Volgraf, Yu Jiang, Guosheng Wu, Cuong Q Ly, Po-Wai Yuen, Aijun Lu, Xifeng Luo, Mingcui Liu, Shun Zhang, Patrick J Lupardus, Heidi J A Wallweber, Bianca M Liederer, Gauri Deshmukh, Emile Plise, Suzanne Tay, Tzu-Ming Wang, Jesse E Hanson, David H Hackos, Kimberly Scearce-Levie, Jacob B Schwarz, Benjamin D Sellers
The N-methyl-d-aspartate receptor (NMDAR) is an ionotropic glutamate receptor, gated by the endogenous coagonists glutamate and glycine, permeable to Ca(2+) and Na(+). NMDAR dysfunction is associated with numerous neurological and psychiatric disorders, including schizophrenia, depression, and Alzheimer's disease. Recently, we have disclosed GNE-0723 (1), a GluN2A subunit-selective and brain-penetrant positive allosteric modulator (PAM) of NMDARs. This work highlights the discovery of a related pyridopyrimidinone core with distinct structure-activity relationships, despite the structural similarity to GNE-0723...
January 12, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28104985/high-risk-of-temporomandibular-disorder-in-irritable-bowel-syndrome-is-there-a-correlation-with-greater-illness-severity
#12
Serena Gallotta, Vincenzo Bruno, Santo Catapano, Nicola Mobilio, Carolina Ciacci, Paola Iovino
AIM: To investigate the prevalence and the risk of temporomandibular disorders (TMDs) in patients with irritable bowel syndrome (IBS) (including each subtype: constipation, diarrhoea, and mixed) compared to the general population. METHODS: Between January 2014 and December 2015 we enrolled consecutively adult patients diagnosed with IBS at the outpatient clinic of the University of Salerno and healthy controls (HC) without IBS. At enrollment, we analyzed all patients for the presence of TMDs according to the Research Diagnostic Criteria for TMD...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28104911/psychiatric-disorders-parsing-depression
#13
Sian Lewis
No abstract text is available yet for this article.
January 20, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28104736/pharmacological-treatment-and-risk-of-psychiatric-hospital-admission-in-bipolar-disorder
#14
Erik Joas, Alina Karanti, Jie Song, Guy M Goodwin, Paul Lichtenstein, Mikael Landén
BACKGROUND: Clinical trials have examined the efficacy of drugs to prevent relapse in patients with bipolar disorder, however, their design often limits generalisation to routine clinical practice. AIMS: To estimate the effectiveness of drugs used for maintenance treatment in bipolar disorder. METHOD: We used national registers to identify 35 022 individuals diagnosed with bipolar disorder and information on lithium, valproate, carbamazepine, lamotrigine, quetiapine and olanzapine treatment from 2006 to 2009...
January 19, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28104556/paternal-environmental-enrichment-transgenerationally-alters-affective-behavioral-and-neuroendocrine-phenotypes
#15
Shlomo Yeshurun, Annabel K Short, Timothy W Bredy, Terence Y Pang, Anthony J Hannan
Recent studies have demonstrated that paternal stress in rodents can result in modification of offspring behavior. Environmental enrichment, which enhances cognitive stimulation and physical activity, modifies various behaviors and reduces stress responses in adult rodents. We investigated the transgenerational influence of paternal environmental enrichment on offspring behavior and physiological stress response. Adult C57BL/6J male mice (F0) were exposed to either environmental enrichment or standard housing for four weeks and then pair-mated with naïve females...
January 4, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28104232/dopamine-agonist-withdrawal-syndrome-a-comprehensive-review
#16
REVIEW
Xin Xin Yu, Hubert H Fernandez
Dopamine agonists are effective and widely used treatments for Parkinson disease (PD). However, patients on dopamine agonists may experience significant side effects which necessitate dose tapering or discontinuation. Dopamine agonist withdrawal syndrome (DAWS) is a complication that affects up to 19% of PD patients who undergo a dopamine agonist taper. It was initially described in 2010 as a severe stereotypical cluster of psychiatric and physical symptoms occurring with dopamine agonist withdrawal. Identified risk factors for DAWS include impulse control behavior disorders (ICD) and higher dopamine agonist dosage...
January 2, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28104065/borderline-personality-disorder-psychological-treatment-an-integrative-review
#17
Beverly Reeves-Dudley
Borderline personality disorder (BPD) is a complex and at times debilitating mental disorder, treatment of which has eluded effective pharmacotherapy (Gunderson, 2007). Although once considered untreatable, psychodynamic therapy and cognitive therapy (two types of psychological therapies) have provided hope for better lives for patients with this diagnosis (Gunderson). The author performed an integrative review of the literature pertaining to the present role of evidence-based practice (EBP) using the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision (DSM-IV-TR) definition of BPD to identify symptoms of the disorder...
February 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28104051/relation-between-emotional-intelligence-socio-demographic-and-clinical-characteristics-of-patients-with-depressive-disorders
#18
Sayeda Ahmed Abdellatif, El-Sayed Saleh Hussien, Warda Elshahat Hamed, Mohamed Ali Zoromba
The present study aims to assess the emotional intelligence in relation to socio-demographic and clinical characteristics of patients with depressive disorders. A descriptive correlational study was utilized with a sample of (106) depressed patients who were diagnosed by a psychiatrist with depressive disorders at psychiatric outpatient clinics in Mansoura University Hospital. Data were collected through assessing socio demographic and clinical characteristics, assessing level of depression using Beck Depression Inventory BDI-II, and assessing emotional intelligence using Barchard emotional intelligence scales...
February 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28103841/a-two-site-two-arm-34-week-double-blind-parallel-group-randomized-controlled-trial-of-reduced-nicotine-cigarettes-in-smokers-with-mood-and-or-anxiety-disorders-trial-design-and-protocol
#19
Sophia I Allen, Jonathan Foulds, Gladys N Pachas, Susan Veldheer, Corinne Cather, Nour Azzouz, Shari Hrabovsky, Ahmad Hameed, Jessica Yingst, Erin Hammett, Jennifer Modesto, Nicolle M Krebs, Junjia Zhu, Jason Liao, Joshua E Muscat, John Richie, A Eden Evins
BACKGROUND: The U.S. Food and Drug Administration can set standards for cigarettes that could include reducing their nicotine content. Such a standard should improve public health without causing unintended serious consequences for sub-populations. This study evaluates the effect of progressive nicotine reduction in cigarettes on smoking behavior, toxicant exposure, and psychiatric symptoms in smokers with comorbid mood and/or anxiety disorders using a two-site, two-arm, double-blind, parallel group, randomized controlled trial (RCT) in four phases over 34 weeks...
January 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28103527/distinct-cortico-striatal-connections-with-subthalamic-nucleus-underlie-facets-of-compulsivity
#20
Laurel S Morris, Kwangyeol Baek, Valerie Voon
The capacity to flexibly respond to contextual changes is crucial to adapting to a dynamic environment. Compulsivity, or behavioural inflexibility, consists of heterogeneous subtypes with overlapping yet discrete neural substrates. The subthalamic nucleus (STN) mediates the switch from automatic to controlled processing to slow, break or stop behaviour when necessary. Rodent STN lesions or inactivation are linked with perseveration or repetitive, compulsive responding. However, there are few studies examining the role of latent STN-centric neural networks and compulsive behaviour in healthy individuals...
December 29, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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