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https://www.readbyqxmd.com/read/29451101/severe-tricuspid-regurgitation-and-seizure-on-postpartum-day-10-case-report-of-late-postpartum-eclampsia
#1
Martin Vanden Eede, Matthew Schroyens
OBJECTIVE AND IMPORTANCE: Late postpartum eclampsia is characterized by pre-eclampsia and tonic-clonic seizures presenting more than 48 hours postpartum. It is a rare, frightening and dangerous complication that requires rapid recognition and adequate treatment. CLINICAL PRESENTATION: We present a case of late postpartum eclampsia, initially diagnosed as right-sided heart failure, 10 days postpartum.Two days after the delivery she developed mild swelling of both feet, progressive shortness of breath on exertion and orthopnea...
February 16, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29433838/preliminary-asian-experience-of-using-perampanel-in-clinical-practice
#2
Hsing-I Chiang, Siew-Na Lim, Hsiang-Yao Hsieh, Mei-Yun Cheng, Chun-Wei Chang, Wei-En Johnny Tseng, Han-Tao Li, Chin-Yin Lin, Tony Wu
BACKGROUND: To analyze the efficacy and safety of perampanel over a 3-month period in a sample of Asian people with epilepsy. METHODS: The efficacy and safety of perampanel as an adjunctive therapy for patients with epilepsy were retrospectively reviewed and analyzed. Patients were categorized according to seizure type, concomitant antiepileptic drug usage, and perampanel dosage. RESULTS: A total of 210 patients were included in the study and 131 patients completed 3 months of perampanel treatment...
December 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29433669/behavioral-and-electroencephalographic-evaluation-of-the-anticonvulsive-activity-of-moringa-oleifera-leaf-non-polar-extracts-and-one-metabolite-in-ptz-induced-seizures
#3
María Eva González-Trujano, Claudia Lizbeth Martínez-González, Maricela Flores-Carrillo, Sara Ibeth Luna-Nophal, Gerardo Contreras-Murillo, Víctor Manuel Magdaleno-Madrigal
BACKGORUND: Moringa oleifera Lamarck is a species that has long been used in high demand in folk medicine, including for the treatment of epilepsy. Nevertheless, scientific studies demonstrating its anticonvulsant properties and the nature of the bioactive constituents are lacking. HYPOTHESIS/AIM: The aim of this study was to evaluate the anticonvulsant activities of the Moringa oleifera leaves in non-polar vs. polar extracts using behavioral and electroencephalographic (EEG) analyses in rodents...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29428275/familial-cases-of-progressive-myoclonic-epilepsy-caused-by-maternal-somatic-mosaicism-of-a-recurrent-kcnc1-p-arg320his-mutation
#4
Hyuna Kim, Sangmoon Lee, Murim Choi, Hunmin Kim, Hee Hwang, JiEun Choi, Jong Hee Chae, Ki Joong Kim, Byung Chan Lim
PURPOSE: A recurrent de novo mutation in KCNC1 (c.959G > A, p.Arg320His) has been identified recently as one of the important genetic causes of progress myoclonic epilepsy (PME). The clinical phenotype resulting from this mutation has been named as myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK). This finding carries important clinical implications in that autosomal dominant inheritance and de novo occurrence need to be considered when conducting genetic tests in patients with PME...
February 8, 2018: Brain & Development
https://www.readbyqxmd.com/read/29427285/effect-of-tadalafil-on-seizure-threshold-and-activity-of-antiepileptic-drugs-in-three-acute-seizure-tests-in-mice
#5
Katarzyna Socała, Dorota Nieoczym, Mateusz Pieróg, Elżbieta Wyska, Małgorzata Szafarz, Urszula Doboszewska, Piotr Wlaź
Tadalafil, a selective phosphodiesterase type 5 inhibitor, is a long-acting oral agent for the treatment of erectile dysfunction of multiple etiologies. Although generalized tonic-clonic seizures were reported in a healthy man after taking tadalafil, the influence of tadalafil on seizure susceptibility has not been studied so far. Therefore, the aim of the present study was to investigate the effect of tadalafil on seizure threshold as well as on the activity of some first- and second-generation antiepileptic drugs in three acute seizure tests in mice...
February 9, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29422850/a-native-haitian-woman-with-unverricht-lundborg-disease
#6
Maliheh Mohamadpour, Genevieve Gabriel, Arthur C Grant
Unverricht-Lundborg disease (ULD) is an autosomal recessive progressive myoclonic epilepsy. The prevalence is highest in specific European countries and North Africa. Affected individuals have myoclonic and tonic-clonic seizures and a variable degree of ataxia and cognitive impairment. We report a native Haitian woman with ULD who was wheelchair bound due to nearly continuous myoclonic seizures exacerbated by activity and emotional distress. The seizures and their dramatic increase with volitional activity were recorded during video electroencephalography monitoring...
September 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/29422541/micronization-potentiates-curcumin-s-anti-seizure-effect-and-brings-an-important-advance-in-epilepsy-treatment
#7
Kanandra Taisa Bertoncello, Gean Pablo S Aguiar, J Vladimir Oliveira, Anna Maria Siebel
Epilepsy is one of the most common neurological diseases, and current antiepileptic drugs fail to suppress seizure occurrence in around one third of epileptic patients. Curcumin is a phytochemical with promising effects on epilepsy treatment. However, its application has been hindered by its low bioavailability. In order to improve curcumin's anti-seizure properties, increasing its bioavailability, here we proposed to micronize the compound through supercritical carbon dioxide processing, a suitable green chemistry technique to prepare and modify material properties...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29414538/antiepileptic-drug-reduction-and-increased-risk-of-stimulation-evoked-focal-to-bilateral-tonic-clonic-seizure-during-cortical-stimulation-in-patients-with-focal-epilepsy
#8
Kevin G Hampel, Asier Gómez-Ibáñez, Mercedes Garcés-Sánchez, David Hervás-Marín, Irene Cano-López, Esperanza González-Bono, Rebeca Conde-Sardón, Antonio Gutiérrez-Martín, Vicente Villanueva
INTRODUCTION: Stimulation-evoked focal to bilateral tonic-clonic seizure (FBTCS) can be a stressful and possibly harmful adverse event for patients during cortical stimulation (CS). We evaluated if drug load reduction of antiepileptic drugs (AEDs) during CS increases the risk of stimulation-evoked FBTCS. MATERIAL AND METHODS: In this retrospective cohort study, we searched our local database for patients with drug-resistant epilepsy who underwent invasive video-EEG monitoring and CS in the University Hospital la Fe Valencia from January 2006 to November 2016...
February 1, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29411537/developmental-and-sex-differences-in-tetramethylenedisulfotetramine-tmdt-induced-syndrome-in-rats
#9
Marcela Lauková, Jana Velíšková, Libor Velíšek, Michael P Shakarjian
Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide considered a chemical threat agent. Symptoms of intoxication include seizures leading to status epilepticus and death. While children and women have been often the victims, no studies exist investigating the neurotoxic effects of TMDT in developing individuals or females. Thus, we performed such an investigation in developing Sprague-Dawley rats of both sexes in order to identify potential age- or sex-dependent vulnerability to TMDT exposure...
February 7, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29403319/a-review-of-the-pharmacology-and-clinical-efficacy-of-brivaracetam
#10
REVIEW
Pavel Klein, Anyzeila Diaz, Teresa Gasalla, John Whitesides
Brivaracetam (BRV; Briviact) is a new antiepileptic drug (AED) approved for adjunctive treatment of focal (partial-onset) seizures in adults. BRV is a selective, high-affinity ligand for synaptic vesicle 2A (SV2A) with 15- to 30-fold higher affinity than levetiracetam, the first AED acting on SV2A. It has high lipid solubility and rapid brain penetration, with engagement of the target molecule, SV2A, within minutes of administration. BRV has potent broad-spectrum antiepileptic activity in animal models. Phase I studies indicated BRV was well tolerated and showed a favorable pharmacokinetic profile over a wide dose range following single (10-1,000 mg) and multiple (200-800 mg/day) oral dosing...
2018: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/29402633/first-aid-management-of-tonic-clonic-seizures-among-healthcare-personnel-a-survey-by-the-apulian-section-of-the-italian-league-against-epilepsy
#11
Tommaso Martino, Alessandra Lalla, Elena Carapelle, Maria Teresa Di Claudio, Carlo Avolio, Giuseppe d'Orsi
INTRODUCTION: To evaluate the knowledge of healthcare workers about first-aid measures to be performed during and after a tonic-clonic seizure. METHODS: One hundred and fifty-four healthcare workers (86 physicians) working at 8 tertiary hospitals in the Apulia region, Italy, responded to a questionnaire comprising of 28 questions based on available Italian and international recommendations about what to do during a tonic-clonic seizure. RESULTS: One hundred and fifty-four healthcare workers completed and returned surveys with a response rate of 96...
February 2, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29396359/efficacy-and-tolerability-of-adjuvant-lacosamide-the-role-of-clinical-characteristics-and-mechanisms-of-action-of-concomitant-aeds
#12
Andrew Neal, Wendyl D'Souza, Graham Hepworth, Nicholas Lawn, Mark Cook, Armin Nikpour
OBJECTIVE: The objective of this study was to analyze the effectiveness and long-term tolerability of adjuvant lacosamide (LCM) in a multicenter cohort. We aim to assess outcomes of LCM-containing antiepileptic drug (AED) combinations based upon 'mechanism of action' (MoA) and patient's clinical features. METHODS: Consecutive patients commenced on LCM, with focal epilepsy were identified from three Australian hospitals. The 12-month efficacy endpoints were greater than 50% reduction in seizure frequency (responders) and seizure freedom...
January 21, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29394643/-a-case-with-solitary-brain-metastatic-tumor-from-colon-cancer
#13
Masamichi Kimura, Hiroyuki Tanishima, Taichi Tatsubayashi, Shinji Iwakura, Toshiji Tominaga, Tetsuya Horiuchi
We report a rare long-surviving case of solitary brain metastasis from colon cancer. The patient was a 64-year-old female. She had undergone laparoscopic right hemicolectomy for ascending colon cancer in October 2012(pStage III b). She was discharged from the hospitalin a satisfactory state, but 26 days after the operation, she was transported to the emergency department for systemic tonic-clonic convulsions. Magnetic resonance imaging revealed solitary metastatic tumor in the brain, but there were no metastatic lesions in other organs...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29371079/schizencephaly-in-children-a-single-medical-center-retrospective-study
#14
Po-Cheng Hung, Huei-Shyong Wang, Ming-Liang Chou, Kuang-Lin Lin, Meng-Ying Hsieh, I-Jun Chou, Alex M-C Wong
BACKGROUND: The aim of this study was to evaluate the clinical, and neuroimaging features, outcomes, and other associated systemic disorders in children with schizencephaly at a single medical center in Taiwan. METHODS: We retrospectively reviewed the medical records and magnetic resonance images (MRI) of children with schizencephaly between January 2000 and December 2014. The MRI findings of schizencephaly were recorded along with the presence of associated cerebral disorders...
January 6, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29367179/childhood-onset-generalized-epilepsy-in-bainbridge-ropers-syndrome
#15
Kenneth A Myers, Susan M White, Shehla Mohammed, Kay A Metcalfe, Andrew E Fry, Elisabeth Wraige, Pradeep C Vasudevan, Meena Balasubramanian, Ingrid E Scheffer
Bainbridge-Ropers syndrome is a genetic syndrome caused by heterozygous loss-of-function pathogenic variants in ASXL3, which encodes a protein involved in transcriptional regulation. Affected individuals have multiple abnormalities including developmental impairment, hypotonia and characteristic facial features. Seizures are reported in approximately a third of cases; however, the epileptology has not been thoroughly studied. We identified three patients with pathogenic ASXL3 variants and seizures at Austin Health and in the DECIPHER database...
January 20, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29348303/absence-epilepsy-beyond-adolescence-an-outcome-analysis-after-45-years-of-follow-up
#16
Martin Holtkamp, Dieter Janz, Andrea Kirschbaum, Alexander B Kowski, Bernd J Vorderwülbecke
OBJECTIVES: Depending on patient age at onset, absence epilepsy is subdivided into childhood and juvenile forms. Absence seizures can occur several times per day (pyknoleptic course) or less frequently than daily (non-pyknoleptic course). Seizures typically terminate before adulthood, but a quarter of patients need ongoing treatment beyond adolescence. Little is known about their long-term seizure and psychosocial outcome. METHODS: Files of 135 outpatients with absence epilepsy (76 females; 123 had additional generalised tonic-clonic seizures) were retrospectively analysed after a median follow-up of 45...
January 18, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29346088/intense-olfactory-stimulation-blocks-seizures-in-an-experimental-model-of-epilepsy
#17
Polianna Delfino-Pereira, Poliana Bertti-Dutra, Eduardo Henrique de Lima Umeoka, José Antônio Cortes de Oliveira, Victor Rodrigues Santos, Artur Fernandes, Simone Saldanha Marroni, Flávio Del Vecchio, Norberto Garcia-Cairasco
There are reports of patients whose epileptic seizures are prevented by means of olfactory stimulation. Similar findings were described in animal models of epilepsy, such as the electrical kindling of amygdala, where olfactory stimulation with toluene (TOL) suppressed seizures in most rats, even when the stimuli were 20% above the threshold to evoke seizures in already kindled animals. The Wistar Audiogenic Rat (WAR) strain is a model of tonic-clonic seizures induced by acute acoustic stimulation, although it also expresses limbic seizures when repeated acoustic stimulation occurs - a process known as audiogenic kindling (AK)...
January 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29344472/status-epilepticus-as-an-unusual-manifestation-of-heat-stroke
#18
Won Gu Lee, So-Young Huh, Jin-Hyung Lee, Bong Goo Yoo, Meyung Kug Kim
Heat stroke (HS) is a medical emergency and life threatening condition, characterized by body temperature over 40°C. This can lead to dysfunction of multiple organs such as the heart, liver, kidneys, lungs, blood coagulation system, and central nervous system. Neurological complications include change in consciousness, cerebellar dysfunction, convulsions, aphasia, muscular weakness, and parkinsonism. Cerebellar syndrome is the most common neurological finding in HS. We report a case of HS presenting with status epilepticus, without any other neurological manifestations...
December 2017: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/29344464/cannabinoids-in-the-treatment-of-epilepsy-hard-evidence-at-last
#19
REVIEW
Emilio Perucca
The interest in cannabis-based products for the treatment of refractory epilepsy has skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ(9) - tetrahydrocannabinol (THC), utilized primarily for recreational purposes, are generally unsuitable for this indication, primarily because THC is associated with many undesired effects. Compared with THC, cannabidiol (CBD) shows a better defined anticonvulsant profile in animal models and is largely devoid of adverse psychoactive effects and abuse liability...
December 2017: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/29335023/early-neonatal-glutaric-aciduria-type-i-hidden-by-perinatal-asphyxia-a-case-report
#20
Giacomo Biasucci, Nicola Morelli, Federica Natacci, Massimo Mastrangelo
BACKGROUND: Perinatal asphyxia (PA) occurs in about 2 to 10 per 1000 live full-term births. Although neonatal epileptic seizures are observed in up to 60% of cases, PA may mimic or subtend other conditions. Hypoxia related brain injury is particularly relevant, as it may have permanent effects on neuropsychomotor development. Antepartum obstetric conditions, may, in turn, lead to hypoxic-ischemic damage to the fetus and the newborn, often underlying PA. Herein, a case of PA that hid and triggered signs and symptoms of Glutaric Aciduria type I (GA-I), is reported...
January 15, 2018: Italian Journal of Pediatrics
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