Farid Kurniawan, Imam Subekti, Em Yunir, Dante Saksono Harbuwono, Dyah Purnamasari, Tri Juli Edi Tarigan, Wismandari Wisnu, Dicky Levenus Tahapary, Syahidatul Wafa, Cindy Astrella, Eunike Vania Christabel, Anna Mira Lubis, Ika Prasetya Wijaya, Birry Karim, Mohamad Syahrir Azizi, Indrati Suroyo, Sahat Matondang, Krishna Pandu Wicaksono, Dewi Wulandari, Iqbal Fasha, Cynthia Retna Sartika, Cosphiadi Irawan, Pradana Soewondo
BACKGROUND: Type 2 diabetes (T2D) is a progressive disease. Many drugs currently being used for the management of T2D have minimal effect on pancreatic beta cells regeneration. Cell-based therapies might provide potential benefits in this aspect. METHODS: A pilot study in five T2D patients with 12 months follow-up was performed to evaluate the effect of autologous bone marrow mononuclear stem cells (BM-MNCs) infusion into pancreatic arteries on the insulin requirement, beta-cell function, insulin resistance, and systemic inflammatory marker (CRP)...
December 29, 2023: Current Research in Translational Medicine