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cryo biopsy of lung

Theresia A Mikolasch, Helen S Garthwaite, Joanna C Porter
The field of interstitial lung disease (ILD) has undergone significant evolution in recent years, with an increasing incidence and more complex, ever expanding disease classification. In their most severe forms, these diseases lead to progressive loss of lung function, respiratory failure and eventually death. Despite notable advances, progress has been challenged by a poor understanding of pathological mechanisms and patient heterogeneity, including variable progression. The diagnostic pathway is thus being continually refined, with the introduction of tools such as transbronchial cryo lung biopsy and a move towards genetically aided, precision medicine...
December 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
Eric H Kim, Gerald L Andriole, E David Crawford, Daniel D Sjoberg, Melissa Assel, Andrew J Vickers, Hans Lilja
PURPOSE: We assessed the performance of a 4-kallikrein panel with and without microseminoprotein-β to predict high grade (Gleason 7+/Gleason Grade Group 2+) prostate cancer on biopsy in a multiethnic cohort from PLCO (Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial). MATERIALS AND METHODS: Levels of free, intact, total prostate specific antigen, human kallikrein-2 and microseminoprotein-β were measured while blinded to outcomes in cryopreserved serum from men in the intervention arm of PLCO...
November 1, 2016: Journal of Urology
Lars Hagmeyer, Dirk Theegarten, Marcel Treml, Christina Priegnitz, Winfried Randerath
BACKGROUND: Transbronchial Cryobiopsy (Cryo-TBB) represents a new approach for sampling lung tissue in interstitial lung disease (ILD). OBJECTIVES: Comparing the reliability of Cryo-TBB results and the procedure's complication rates with the procedure of surgical lung biopsy (SLB). METHODS: ILD subjects with the need of lung tissue sampling are analyzed in this prospective trial. To determine the relevance of procedure-related complications the pooled data from the ongoing and previous Cryo-TBB studies were compared with pooled data from previous SLB studies in an interim analysis...
March 29, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
Sahajal Dhooria, Inderpaul Singh Sehgal, Ashutosh N Aggarwal, Digambar Behera, Ritesh Agarwal
BACKGROUND: Transbronchial lung biopsy with flexible forceps is the most commonly used technique in diagnosis of diseases diffusely involving the lung parenchyma. Recently, transbronchial lung biopsy using the flexible cryoprobe (cryo-transbronchial lung biopsy) has also been reported. Herein, we perform a systematic review and meta-analysis describing the efficacy and safety of cryo-transbronchial lung biopsy. METHODS: The PubMed and EMBASE databases were searched for studies reporting the outcomes of cryo-transbronchial lung biopsy in subjects with diffuse parenchymal lung involvement...
May 2016: Respiratory Care
A T Morresi-Hauf, S Reu, M Heiß-Neumann, W Gesierich, T Richter, P K Wagner
In two patients with bilateral micronodular pulmonary changes a diffuse pulmonary meningotheliomatosis was found. A 73-year-old woman presented with bilateral disseminated miliary pulmonary nodules as a radiological incidental finding. The surgical lung biopsy showed multiple tiny nodular proliferations meningothelial-like cells, corresponding "minute pulmonary meningothelial-like nodules", MPMN. A 60-year-old lady with similar radiological findings showed also proliferations of meningothelial-like cells in a transbronchial cryo-biopsy...
September 2015: Pneumologie
Evgeni Gershman, Oren Fruchter, Fox Benjamin, Abed Rahman Nader, Dror Rosengarten, Victoria Rusanov, Ludmila Fridel, Mordechai R Kramer
BACKGROUND: Transbronchial biopsy (TBB) which is performed with metal forceps (forceps TBB) has been accepted as a useful technique in establishing diagnoses of diffuse lung diseases (DLDs). The use of cryoprobes to obtain alveolar tissue (cryo-TBB) is a new method which is currently used by our institute as well as others with excellent results. OBJECTIVES: To assess the safety of cryo-TBB compared with conventional forceps TBB. METHODS: We performed a retrospective data evaluation of 300 consecutive patients who underwent cryo-TBB between January 2012 and April 2014 and compared them with historical cases treated with forceps TBB between 2010 and 2012...
2015: Respiration; International Review of Thoracic Diseases
Oren Fruchter, Ludmila Fridel, Bayya Abed El Raouf, Nader Abdel-Rahman, Dror Rosengarten, Mordechai R Kramer
BACKGROUND AND OBJECTIVE: The gold standard for the histological diagnosis of interstitial lung diseases (ILD) is an open lung biopsy (OLB). Tissue samples obtained by forceps transbronchial lung biopsies (TBB) are usually too small. We aim to evaluate the efficacy and safety of cryo-TBB for the diagnosis of ILD and to explore its role as substitute for OLB. METHODS: Seventy-five patients (mean age 56.2 years) with clinical and radiological features suggestive of ILD underwent cryo-TBB under moderate sedation...
July 2014: Respirology: Official Journal of the Asian Pacific Society of Respirology
Jonathan A Kropski, Jason M Pritchett, Wendi R Mason, Lakshmi Sivarajan, Linda A Gleaves, Joyce E Johnson, Lisa H Lancaster, William E Lawson, Timothy S Blackwell, Mark P Steele, James E Loyd, Otis B Rickman
BACKGROUND: Although in some cases clinical and radiographic features may be sufficient to establish a diagnosis of diffuse parenchymal lung disease (DPLD), surgical lung biopsy is frequently required. Recently a new technique for bronchoscopic lung biopsy has been developed using flexible cryo-probes. In this study we describe our clinical experience using bronchoscopic cryobiopsy for diagnosis of diffuse lung disease. METHODS: A retrospective study of subjects who had undergone bronchoscopic cryobiopsy for evaluation of DPLD at an academic tertiary care center from January 1, 2012 through January 15, 2013 was performed...
2013: PloS One
Oren Fruchter, Ludmila Fridel, Dror Rosengarten, Nader Abed-el Rahman, Mordechai R Kramer
BACKGROUND: In immunocompromised patients with pulmonary infiltrates, transbronchial lung biopsies (TBB) obtained by forceps has been shown to increase the diagnostic yield over simple bronchoalveolar lavage. Cryo-TBB is a novel modality for obtaining lung biopsies. We aimed to evaluate for the first time the efficacy and safety of cryo-TBB in immunocompromised patients. METHODS: Fifteen immunocompromised patients with pulmonary infiltrates underwent cryo-TBB. During the procedure two to three biopsy samples were taken...
December 2013: Lung
Oren Fruchter, Ludmila Fridel, Dror Rosengarten, Yael Raviv, Viktoria Rosanov, Mordechai R Kramer
BACKGROUND AND OBJECTIVE: Transbronchial lung biopsies remain the gold standard to establish the presence of allograft rejection or infection after lung transplantation. The aim of this study was to evaluate the efficacy and safety of cryo-transbronchial biopsies (cryo-TBB) in lung transplantation patients. METHODS: Forty lung transplantation patients (mean age 58.3 years) underwent cryo-TBB, either routine post lung transplantation surveillance bronchoscopy (n = 27), or clinically indicated bronchoscopy (n = 13)...
May 2013: Respirology: Official Journal of the Asian Pacific Society of Respirology
A Gangi, X Buy
Interventional radiology has made great progress during the past decade. In thoracic oncology image guided, percutaneous procedures may be divided into two groups: diagnostic and therapeutic. The routinely performed diagnostic procedures include percutaneous biopsy of parenchymal and mediastinal lesions under fluoroscopic or CT guidance. The therapeutic procedures are mainly concerned with the relief of pain. Percutaneous injection of alcohol into bone metastases was one of the first techniques used. Percutaneous vertebroplasty by injection of acrylic cement into lytic lesions of the vertebral bodies is one of the most successful techniques in interventional radiology...
October 2007: Revue des Maladies Respiratoires
Brooks D Cash, Lavonne R Johnston, Mark H Johnston
BACKGROUND: Esophageal carcinoma is the ninth most prevalent cancer worldwide with squamous cell carcinoma (SCCA) and adenocarcinoma accounting for the vast majority of new cases (13,900 in 2003). Cure rates in the U.S. are less than 10%, similar to lung cancer. More than 50% of patients with esophageal carcinoma present with unresectable or metastatic disease, are not surgical candidates, or display disease progression despite the addition of neoadjuvant chemoradiotherapy to surgery...
2007: World Journal of Surgical Oncology
Leon M van den Toorn, Jan-Bas Prins, Johan C de Jongste, Karolina Leman, Paul G H Mulder, Henk C Hoogsteden, Shelley E Overbeek
STUDY OBJECTIVES: Subjects with atopic asthma often experience a disappearance of symptoms around puberty. However, airway inflammation and remodeling may persist. It is unknown whether those findings warrant prolonged anti-inflammatory treatment despite the absence of symptoms. In this study, we investigated whether a short course of combined anti-inflammatory treatment would, also in this specific patient population, diminish airway inflammation and/or remodeling. DESIGN: A double-blind, randomized placebo-controlled trial was conducted in 28 asymptomatic subjects with a history of atopic asthma, with established bronchial hyperresponsiveness to methacholine (MCh) as non-invasive indicator of ongoing airway pathology...
June 2005: Respiratory Medicine
Tatjana Ilić, Dragana Popović-Kuzmanović, Anka Milicić, Svetlana Paranos
Churg-Strauss syndrome (CSS) is medium blood vessels vasculitis with predilection for lungs in patients with bronchial asthma, chronic eosinophilic pneumonia and positive ANCA in the sera in 55-67%. This is a case report of a 60 years old female patient with bronchial asthma, peripherial pulmonary infiltrations, blood eosinophilia, xerophtalmia, tachycardia, chronic rhinosinustis, polyneuropathia and negative imunological tests: CIC (PEG), CRYO, ANA (IIF), RF (aglutination) and ANCA (IFF: pANCA and cANCA; ELISA: proteinase 3, lactoferrin, myeloperoxidase...
March 2002: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
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