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ocular coherent tomography

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https://www.readbyqxmd.com/read/28108907/peripapillary-retinal-nerve-fiber-layer-and-ganglion-cell-inner-plexiform-layer-thickness-in-adult-onset-familial-mediterranean-fever
#1
Sait Alim, Mehmet Esen, Ayşe Kevser Demir, Selim Demir, Hüseyin Ortak, Alper Güneş, Tufan Alatli, Helin Deniz Demir
OBJECTIVE: The purpose of the present study was to evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell-inner plexiform layer (GCIPL) in adult-onset familial Mediterranean fever (FMF). METHODS: Forty two adult-onset FMF patients and forty two healthy controls were included in the present study. Detailed ocular examination was performed, and then the thickness of the peripapillary RNFL and GCIPL was measured by Spectral domain optical coherence tomography...
January 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28107458/neuropilin-1-involvement-in-choroidal-and-retinal-neovascularisation
#2
Patricia Fernández-Robredo, Senthil Selvam, Michael B Powner, Dawn A Sim, Marcus Fruttiger
PURPOSE: Inhibiting VEGF is the gold standard treatment for neovascular age-related macular degeneration (AMD). It is also effective in preventing retinal oedema and neovascularisation (NV) in diabetic retinopathy (DR) and retinal vein occlusions (RVO). Neuropilin 1 (Nrp1) is a co-receptor for VEGF and many other growth factors, and therefore a possible alternative drug target in intra ocular neovascular disease. Here we assessed choroidal and retinal NV in an inducible, endothelial specific knock out model for Nrp1...
2017: PloS One
https://www.readbyqxmd.com/read/28107088/the-national-eye-survey-of-trinidad-and-tobago-nestt-rationale-objectives-and-methodology
#3
Tasanee Braithwaite, Neville Q Verlander, Debra Bartholomew, Petra Bridgemohan, Kevin McNally, Allana Roach, Subash Sharma, Deo Singh, Konrad Pesudovs, Surujpal Teelucksingh, Christine Carrington, Samuel Ramsewak, Rupert Bourne
PURPOSE: This paper describes the rationale, study design and procedures of the National Eye Survey of Trinidad and Tobago (NESTT). The main objective of this survey is to obtain prevalence estimates of vision impairment and blindness for planning and policy development. METHODS: A population-based, cross-sectional survey was undertaken using random multistage cluster sampling, with probability-proportionate-to-size methods. Eligible participants aged 5 years and older were sampled from the non-institutional population in each of 120 cluster segments...
January 20, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28106626/unusual-serous-retinal-detachment-in-a-patient-with-waldenstrom-macroglobulinemia-a-case-report
#4
Albert B Lin, Alan T Sheyman, Lee M Jampol
BACKGROUND/PURPOSE: To report an unusual appearance of severe bilateral serous detachments in a patient with Waldenstrom macroglobulinemia. METHODS: A case report of a Fifty-six-year-old female patient with Waldenstrom macroglobulinemia. RESULTS: A patient with Waldenstrom macroglobulinemia presented with serous retinal detachments at the time of diagnosis with Waldenstrom. The patient's IgM levels remained abnormally elevated in the initial stages of her disease course, leading to dramatic ocular findings and images on optical coherence tomography...
January 18, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28101398/wide-field-retinal-optical-coherence-tomography-with-wavefront-sensorless-adaptive-optics-for-enhanced-imaging-of-targeted-regions
#5
James Polans, Brenton Keller, Oscar M Carrasco-Zevallos, Francesco LaRocca, Elijah Cole, Heather E Whitson, Eleonora M Lad, Sina Farsiu, Joseph A Izatt
The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring of ocular diseases. We have developed a novel wide-field (>70°) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics (WSAO) for enhancing the visualization of smaller (<25°) targeted regions in the peripheral retina. We iterated the WSAO algorithm at the speed of individual OCT B-scans (~20 ms) by using raw spectral interferograms to calculate the optimization metric...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28101049/tuberculous-subretinal-abscess-in-a-non-hiv-patient-with-miliary-tuberculosis
#6
Eugenia Paez Soria, Paula Magnano, Ariel Schlaen, Paula Luvini, Gisela Arevalo Calderon, Mauricio Martinez Cartier, Pablo Chiaradía, Cristóbal Couto
This case report describes the features of a tuberculous subretinal abscess in a non-HIV patient. It includes the characterization of the lesion with spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence examination. SD-OCT and autofluorescence imaging showed external retinal involvement during development of the tuberculous subretinal abscess. Patients with tuberculous lesions need a multidisciplinary approach, since the disease may involve any part of the body. In this case in particular, incidental findings at computed tomography scan led to the detection of this rare ocular manifestation of tuberculous disease...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28094062/-optic-disc-granuloma-secondary-to-sarcoidosis
#7
L Qu-Knafo, A Auregan-Giocanti
We report a case of optic disc granuloma due to sarcoidosis. A 64-year-old, caucasian female with a history of pulmonary sarcoidosis presented with a vision loss on her left eye. The ophthalmologic examination revealed a discrete optic disc infiltrate compatible with the diagnosis of optic disc granuloma. Fluorescein angiography showed diffusion and impregnation of the granuloma without vascularitis. The optical coherence tomography demonstrated a homogenous and isoreflective lesion at the optic disc. The patient recovered her visual acuity after systemic corticosteroid treatment...
January 13, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28087348/the-eyes-of-children-with-celiac-disease
#8
Arzu Seyhan Karatepe Hashas, Orhan Altunel, Eylem Sevınc, Necati Duru, Bedirhan Alabay, Yasemin Altuner Torun
PURPOSE: To determine possible eye involvement in pediatric patients with celiac disease. METHODS: Children (aged 5-18 years) with classic celiac disease and sex- and age-matched controls were included. In addition to a complete ophthalmologic examination, all patients were scanned by a Scheimpflug camera and spectral domain optical coherence tomography, and Schirmer and break-up time (BUT) tests were performed. Data were evaluated by paired t test, with a P value of <0...
January 10, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28079023/incidence-and-growth-of-geographic-atrophy-during-5-years-of-comparison-of-age-related-macular-degeneration-treatments-trials
#9
Juan E Grunwald, Maxwell Pistilli, Ebenezer Daniel, Gui-Shuang Ying, Wei Pan, Glenn J Jaffe, Cynthia A Toth, Stephanie A Hagstrom, Maureen G Maguire, Daniel F Martin
PURPOSE: To estimate the incidence, size, and growth rate of geographic atrophy (GA) during 5 years of follow-up among participants in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Cohort within a clinical trial. PARTICIPANTS: Participants included in CATT. METHODS: A total of 1185 CATT participants were randomly assigned to ranibizumab or bevacizumab treatment and to 3 treatment regimens...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/28078103/the-potential-of-spectral-domain-optical-coherence-tomography-imaging-based-retinal-biomarkers
#10
REVIEW
Prateep Phadikar, Sandeep Saxena, Surabhi Ruia, Timothy Y Y Lai, Carsten H Meyer, Dean Eliott
BACKGROUND: Biomarker", a merged word of "biological marker", refers to a broad subcategory of medical signs that objectively indicate the state of health, and well-being of an individual. Biomarkers hold great promise for personalized medicine as information gained from diagnostic or progression markers can be used to tailor treatment to the individual for highly effective intervention in the disease process. Optical coherence tomography (OCT) has proved useful in identifying various biomarkers in ocular and systemic diseases...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28076569/optical-coherence-tomography-of-macular-atrophy-associated-with-microcephaly-and-presumed-intrauterine-zika-virus-infection
#11
Adriana Gondim de Moura Campos, Rodrigo Pessoa Cavalcanti Lira, Tiago Eugenio Faria E Arantes
This case report describes the retinal optical coherence tomography (OCT) findings in a microcephalic infant with macular atrophy presumably caused by intrauterine Zika virus infection. OCT demonstrated atrophy of the outer retinal layers and choriocapillaris, including the outer nuclear layer and ellipsoid zone, associated with retinal pigment epithelium hyper-reflectivity and increased OCT penetration into deeper layers of the choroid and sclera. A major concern associated with this infection is the apparent increased incidence of microcephaly in fetuses born to mothers infected with the Zika virus...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28060390/asymptomatic-progression-of-ocular-beh%C3%A3-et-s-disease
#12
Marina Roizenblatt, Nikoly Fares, Heloisa Nascimento, Eduardo A Novais, Cristina Muccioli, Rubens Belfort
BACKGROUND AND OBJECTIVE: To emphasize the importance of auxiliary exams to detect progression of ocular Behçet's disease (BD) in asymptomatic patients. PATIENTS AND METHODS: This was a retrospective review of the clinical records of a consecutive series of patients with BD and asymptomatic visual deterioration, imaged on fundus photograph (FP), visual field (VF), fluorescein angiography (FA), and optical coherence tomography (OCT). RESULTS: Patients presented with no clinical findings or with mild inflammation on ophthalmic examination...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28060389/choroidal-thickness-in-childhood-obesity
#13
Ayse Derya Bulus, Mehmet Erol Can, Ata Baytaroglu, Gamze Dereli Can, Hasan Basri Cakmak, Nesibe Andiran
BACKGROUND AND OBJECTIVE: To evaluate the effects of obesity on choroidal thickness (CT) in childhood. PATIENTS AND METHODS: Forty-four patients with obesity (study group) and 42 healthy children (control group) were enrolled in the study. Subjects underwent a complete ocular examination. The mean CT was measured by enhanced depth imaging optical coherence tomography (EDI-OCT). Body mass index (BMI) was calculated. RESULTS: Mean BMI value was 31...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28060137/infants-with-congenital-zika-syndrome-and-ocular-findings-from-s%C3%A3-o-paulo-brazil-spread-of-infection
#14
João Rafael de Oliveira Dias, Camila V Ventura, Paula Delegrego Borba, Bruno de Paula Freitas, Ligia Camera Pierroti, Ana Patricia do Nascimento, Nilva Simeren Bueno de Moraes, Maurício Maia, Rubens Belfort
BACKGROUND/PURPOSE: To describe the ocular findings of two infants with congenital Zika syndrome born in São Paulo state, Brazil, outside the primary outbreak region. METHODS: Two female infants with congenital Zika syndrome were submitted to a complete screening for infectious diseases, as well as ocular examination, fundus photography, and optical coherence tomography of the retina. One of the infants was submitted to ocular ultrasound. RESULTS: Both children showed positive serology for Zika virus, and other infectious diseases were ruled out...
January 2, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28057562/imaging-retina-to-study-dementia-and-stroke
#15
REVIEW
Carol Yim-Lui Cheung, M Kamran Ikram, Christopher Chen, Tien Yin Wong
With increase in life expectancy, the number of persons suffering from common age-related brain diseases, including neurodegenerative (e.g., dementia) and cerebrovascular (e.g., stroke) disease is expected to rise substantially. As current neuro-imaging modalities such as magnetic resonance imaging may not be able to detect subtle subclinical changes (resolution <100-500 μm) in dementia and stroke, there is an urgent need for other complementary techniques to probe the pathophysiology of these diseases...
January 2, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28054212/assessing-posterior-ocular-structures-in-%C3%AE-thalassemia-minor
#16
Hasan Basri Arifoglu, Bekir Kucuk, Necati Duru, Orhan Altunel, Ahmet Gulhan, Mustafa Ozen, Bilal Aygun, Mustafa Atas
PURPOSE: The aim of this study was to investigate the effect of β-thalassemia minor on choroidal, macular, and peripapillary retinal nerve fiber layer thickness. METHODS: To form the sample, we recruited 40 patients with β-thalassemia minor and 44 healthy participants. We used spectral-domain optical coherence tomography to take all measurements of ocular thickness, as well as measured intraocular pressure, axial length, and central corneal thickness. We later analyzed correlations of hemoglobin levels with ocular parameters...
January 4, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28051361/spectral-domain-optical-coherence-tomography-an-in-vivo-imaging-protocol-for-assessing-retinal-morphology-in-adult-zebrafish
#17
Maria Toms, Dhani Tracey-White, Dhakshi Muhundhakumar, Lina Sprogyte, Adam M Dubis, Mariya Moosajee
The present study outlines a protocol for examining retinal structure in zebrafish, a popular model organism for ocular studies, using spectral domain optical coherence tomography (SD-OCT). We demonstrate how this live imaging modality can be used to obtain high quality images of several retinal features, including the optic nerve, retinal vasculature, and the cone photoreceptor mosaic. Retinal histology sections were obtained from imaged fish for comparison with SD-OCT cross-sectional B-scans. Voronoi domain analysis was used to assess cone photoreceptor packing regularity at 3, 6, and 12 months...
January 4, 2017: Zebrafish
https://www.readbyqxmd.com/read/28050729/acute-lupus-choroidopathy-multimodal-imaging-and-differential-diagnosis-from-central-serous-chorioretinopathy
#18
Murat Hasanreisoglu, Gokcen D Gulpinar Ikiz, Hamit Kucuk, Ozkan Varan, Sengul Ozdek
IMPORTANCE: Systemic lupus erythematosus (SLE) is a thoroughly examined multi-organ disease whose common ocular complications are also well documented. However, SLE choroidopathy, being a rare ocular complication, is needed to be better understood, in order to make the differential diagnosis from clinical conditions such as central serous chorioretinopathy and provide adequate prompt treatment. OBJECTIVE: To provide a clear understanding for the clinical course of SLE choroidopathy by the help of enhanced depth imaging optical coherence tomography, fluorescein angiography, and indocyanine angiography...
January 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28044216/effects-of-age-and-gender-on-macular-thickness-in-healthy-subjects-using-spectral-optical-coherence-tomography-scanning-laser-ophthalmoscopy
#19
Mehmet Çubuk, Burcu Kasım, Yusuf Koçluk, Emine Alyamaç Sukgen
PURPOSE: To examine healthy subjects for normal macular thickness values and determine the effects of gender and age in a Turkish population, using spectral optical coherence tomography/scanning laser ophthalmoscopy (OCT/SLO). MATERIAL AND METHOD: Six hundred fourteen eyes of 307 subjects with no history of ocular diseases and normal ophthalmic examination were recruited in this cross-sectional, prospective study. The participants were divided into three groups based on age (between 20 and 29 years: group 1, between 30 and 39 years: group 2, between 40 and 49 years: group 3)...
January 2, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28042184/the-palisades-of-vogt-in-congenital-corneal-opacification-an-american-ophthalmological-society-thesis
#20
Ken K Nischal, Kira L Lathrop
PURPOSE: The purposes of this study are first, to determine if the palisades of Vogt (POV) are present or absent in cases of congenital corneal opacification (CCO) by using spectral domain ocular coherence tomography (SD-OCT), and second, in those cases already undergoing penetrating keratoplasty (PKP), to see whether the absence or presence of POV corresponds to re-epithelialization following transplant. METHODS: This was a retrospective case review of 20 eyes (10 normal, 10 with CCO) evaluated with SD-OCT...
August 2016: Transactions of the American Ophthalmological Society
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