keyword
https://read.qxmd.com/read/36345090/rehabilitating-cough-dysfunction-in-parkinson-s-disease-a-randomized-controlled-trial
#21
JOURNAL ARTICLE
Michelle S Troche, James A Curtis, Jordanna S Sevitz, Avery E Dakin, Sarah E Perry, James C Borders, Alessandro A Grande, Yuhan Mou, Nora Vanegas-Arroyave, Karen W Hegland
BACKGROUND: Disorders of airway protection (cough and swallowing) are pervasive in Parkinson's disease (PD) resulting in a high incidence of aspiration pneumonia and death. However, there are no randomized controlled trials comparing strength and skill-based approaches to improve airway protection in PD. OBJECTIVES: The aim of this study was to compare expiratory muscle strength training (EMST) and sensorimotor training for airway protection (smTAP) to improve cough-related outcomes in people with PD...
November 7, 2022: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36324909/modified-anterior-transarticular-c1-2-fixation-for-odontoid-fractures-an-approach-with-high-complication-rate-in-geriatric-population
#22
JOURNAL ARTICLE
Mohammed Ahmed Mourad, Andy Ottenbacher, Ahmed R Rizk
Background: In patients over 75 years of age, we applied a modified anterior transarticular C1/2 fixation with reduced pharyngeal mobilization versus the standard anterior triple/quadruple osteosynthesis procedures. Methods: From 2010 to 2018, 29 patients underwent a modified anterior transarticular C1/2 fixation utilizing single odontoid screw fixation through a right-sided Smith-Robinson - (i.e., short and steep screw trajectory for the right and long trajectory for the left side) approach...
2022: Surgical Neurology International
https://read.qxmd.com/read/36298516/a-case-report-multifocal-necrotizing-encephalitis-and-myocarditis-after-bnt162b2-mrna-vaccination-against-covid-19
#23
Michael Mörz
The current report presents the case of a 76-year-old man with Parkinson's disease (PD) who died three weeks after receiving his third COVID-19 vaccination. The patient was first vaccinated in May 2021 with the ChAdOx1 nCov-19 vector vaccine, followed by two doses of the BNT162b2 mRNA vaccine in July and December 2021. The family of the deceased requested an autopsy due to ambiguous clinical signs before death. PD was confirmed by post-mortem examinations. Furthermore, signs of aspiration pneumonia and systemic arteriosclerosis were evident...
October 1, 2022: Vaccines
https://read.qxmd.com/read/36031306/breathing-disorders-in-neurodegenerative-diseases
#24
REVIEW
Soumya Ghosh
Neurodegenerative disorders are a diverse group of conditions caused by progressive degeneration of neurons resulting in cognitive, motor, sensory, and autonomic dysfunction, leading to severe disability and death. Pulmonary dysfunction is relatively common in these conditions, may be present early in the disease, and is less well recognized and treated than other symptoms. There are variable disorders of upper and lower airways, central control of ventilation, strength of respiratory muscles, and breathing during sleep which further impact daily activities and quality of life and have the potential to injure vulnerable neurons...
2022: Handbook of Clinical Neurology
https://read.qxmd.com/read/35860494/relationship-between-pneumonia-and-dysphagia-in-patients-with-multiple-system-atrophy
#25
JOURNAL ARTICLE
Ayako Wada, Michiyuki Kawakami, Yuka Yamada, Kentaro Kaji, Nanako Hijikata, Fumio Liu, Tomoyoshi Otsuka, Tetsuya Tsuji
Introduction: Dysphagia is one of the most clinically significant disabilities in patients with multiple system atrophy (MSA), because it can cause aspiration pneumonia, which is potentially fatal. In this study, the Neuromuscular disease Swallowing Status Scale (NdSSS), which was developed to evaluate dysphagia in patients with neuromuscular diseases, was used to evaluate patients with MSA. In addition, correlation between a history of pneumonia and swallowing function was evaluated...
2022: Frontiers in Neurology
https://read.qxmd.com/read/35844271/hospital-admissions-of-huntington-s-disease-patients-in-a-huntington-s-disease-centre-between-2011-and-2016-a-retrospective-analysis
#26
JOURNAL ARTICLE
Marina Peball, Beatrice Heim, Philipp Ellmerer, Florian Frank, Nadia Busin, Matyas Galffy, Atbin Djamshidian, Klaus Seppi
Background: Huntington's Disease (HD) is a relentlessly progressive genetic neurodegenerative disorder with characteristic motor, psychiatric, and behavioral abnormalities that inevitably results in severe disability and death. Many patients have multiple hospital admissions during the disease course, but there is limited information which problems lead to hospitalization. Objectives: To assess acute reasons for hospital admissions, discharge routes, and clinical characteristics of HD patients in a retrospective analysis...
July 2022: Movement Disorders Clinical Practice
https://read.qxmd.com/read/35811445/an-autopsy-case-of-progressive-supranuclear-palsy-pallido-nigro-luysian-type-with-argyrophilic-grains-clinically-presenting-with-personality-and-behavioral-changes
#27
Yuki Suzuki, Tadashi Adachi, Mayuko Sakuwa, Ryoichi Sakata, Hiroshi Takigawa, Masato Hasegawa, Ritsuko Hanajima
Pallido-nigro-luysian atrophy (PNLA) is a variant of progressive supranuclear palsy (PSP). Patients with PSP sometimes show psychiatric signs, but there are few reports about such signs being associated with PSP-PNLA. Here, we report a case of PSP-PNLA with argyrophilic grains (AGs) in a patient clinically diagnosed as having PSP-frontotemporal dementia (PSP-F). A 74-year-old man described as "kind" presented with impaired memory, irritability, and apathy. He showed levodopa-resistant parkinsonism and postural instability...
October 2022: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://read.qxmd.com/read/35730879/the-dysphagia-investigation-is-there-still-space-for-the-videofluoroscopic-method
#28
JOURNAL ARTICLE
Charles Henrique Dias Marques, Luiz João Abrahão-Júnior, Eponina Maria Oliveira Lemme
AIM: Dysphagia can lead to aspiration pneumonia, impacting the nutritional status and quality of life of the patient. The videofluoroscopy is highlighted for allowing both a real-time evaluation and the recording of the images for later review and analysis. This study aimed to describe the characteristics of the population referred for videofluoroscopy and its value as an investigation method. METHODS: A descriptive and retrospective study was conducted. Exams were analyzed in lateral and anteroposterior views and reviewed using the frame-by-frame analysis software...
2022: Brazilian Archives of Digestive Surgery: ABCD
https://read.qxmd.com/read/35634852/experienced-respiratory-symptoms-and-the-impact-on-daily-life-from-the-perspective-of-people-with-parkinson-s-disease-a-grounded-theory
#29
JOURNAL ARTICLE
Veerle A van de Wetering-van Dongen, Maarten J Nijkrake, Niek Koenders, Philip J van der Wees, Bastiaan R Bloem, Johanna G Kalf
BACKGROUND: Abnormal respiratory function tests can be observed early in the course of Parkinson's disease (PD). A better understanding of the impact of respiratory dysfunction on daily life in PD is needed to prevent later occurring complications as a (aspiration) pneumonia. OBJECTIVE: To explain which respiratory symptoms people with PD or a form of atypical parkinsonism experience and how these symptoms impact on their daily lives. METHODS: This qualitative study used a grounded theory approach...
2022: Journal of Parkinson's Disease
https://read.qxmd.com/read/35611364/progressive-dysphagia-in-patient-with-cervical-plate-complicated-with-posterior-pharyngeal-wall-erosion
#30
Davood K Hosseini, Ramtin Moradi, Tyler Schoch, Lesley Philip, Nilesh B Shukla
A 58-year-old male patient with a history of Parkinson's disease and solitary cervical spinal sarcoma underwent corpectomy, a fusion of C3-C6 with cervical fixation plate placement, and stereotactic body radiation therapy, presented 18 months following surgery with dysphagia, concomitant with weakness, diplopia. The initial workup in cervical magnetic resonance imaging (MRI) revealed aerodigestive tract soft tissue enhancement. Dysphagia progressed during hospitalization, and the patient was intubated due to aspiration pneumonia and respiratory failure...
May 2022: Curēus
https://read.qxmd.com/read/35602824/the-impact-of-covid-19-infection-on-a-neurologically-compromised-male-with-fahr-s-disease-presenting-with-acute-delirium-and-aspiration-pneumonia-a-case-report
#31
Rubal Bhangal, Jasmine K Sandhu, Zaryab Umar, Deesha Shah, Nso Nso
Fahr's disease or idiopathic basal ganglia calcification is a rare, sporadic, genetically dominant, and inherited neurological condition that manifests with dysphagia and Parkinson's disease. The computed tomography (CT) scan is the method of choice to diagnose basal ganglia calcifications seen in Fahr's disease. This case report elaborates on the emergency management of a 58-year-old male patient with acute respiratory distress, acute delirium, schizophrenia, Fahr's syndrome, and history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 or COVID-19) infection...
April 2022: Curēus
https://read.qxmd.com/read/35507635/identifying-rates-and-risk-factors-for-medication-errors-during-hospitalization-in-the-australian-parkinson-s-disease-population-a-3-year-multi-center-study
#32
MULTICENTER STUDY
Michael Bakker, Michaela E Johnson, Lauren Corre, Deanna N Mill, Xingzhuo Li, Richard J Woodman, Jacinta L Johnson
BACKGROUND: Admission to hospital introduces risks for people with Parkinson's disease in maintaining continuity of their highly individualized medication regimens, which increases their risk of medication errors. This is of particular concern as omitted medications and irregular dosing can cause an immediate increase in an individual's symptoms as well as other adverse outcomes such as swallowing difficulties, aspiration pneumonia, frozen gait and even potentially fatal neuroleptic malignant type syndrome...
2022: PloS One
https://read.qxmd.com/read/35503446/capsaicin-may-improve-swallowing-impairment-in-patients-with-amyotrophic-lateral-sclerosis-a-randomized-controlled-trial
#33
RANDOMIZED CONTROLLED TRIAL
Tomoko Higashi, Naomichi Murata, Maki Fujimoto, Saki Miyake, Masahiko Egusa, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki
Patients with neurodegenerative diseases are at an increased risk of dysphagia and aspiration pneumonia. In this study, we examined whether ingestion of capsaicin prior to swallowing changes the temporal dynamics of swallowing in such patients. In a crossover, randomized controlled trial, 29 patients with neurodegenerative diseases were given a soluble wafer containing 1.5 μg capsaicin or an identical placebo 20 min prior to testing. For evaluation with video fluoroscopy (VF), patients consumed a barium-containing liquid plus thickening material...
April 2022: Acta Medica Okayama
https://read.qxmd.com/read/35408858/respiratory-abnormalities-in-parkinson-s-disease-what-do-we-know-from-studies-in-humans-and-animal-models
#34
REVIEW
Katarzyna Kaczyńska, Magdalena Ewa Orłowska, Kryspin Andrzejewski
Parkinson's disease (PD) is the second most common progressive neurodegenerative disease characterized by movement disorders due to the progressive loss of dopaminergic neurons in the ventrolateral region of the substantia nigra pars compacta (SNpc). Apart from the cardinal motor symptoms such as rigidity and bradykinesia, non-motor symptoms including those associated with respiratory dysfunction are of increasing interest. Not only can they impair the patients' quality of life but they also can cause aspiration pneumonia, which is the leading cause of death among PD patients...
March 23, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35362009/recognising-and-responding-to-communication-and-swallowing-difficulties-in-parkinson-s-disease
#35
JOURNAL ARTICLE
Sally Ireland, Vincent Carroll, Denise Blanchard, Rachel Rossiter
BACKGROUND: Communication difficulties, including hypokinetic dysarthria and swallowing difficulties (dysphagia), affect a large percentage of people diagnosed with Parkinson's disease. Onset of these symptoms has been identified in up to 78% of people with early-stage Parkinson's disease. Communication difficulties are frequently disregarded until they have a significant impact on quality of life, while the person may often be unaware of indicators of dysphagia and the associated risk of aspiration pneumonia...
April 2022: Australian Journal of General Practice
https://read.qxmd.com/read/35332158/gastrointestinal-involvement-in-parkinson-s-disease-pathophysiology-diagnosis-and-management
#36
REVIEW
T Warnecke, K-H Schäfer, I Claus, K Del Tredici, W H Jost
Growing evidence suggests an increasing significance for the extent of gastrointestinal tract (GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms, including dysphagia, sialorrhea, bloating, nausea, vomiting, gastroparesis, and constipation during the disease course. The underlying pathomechanisms of this α-synucleinopathy play an important role in disease development and progression, i.e., early accumulation of Lewy pathology in the enteric and central nervous systems is implicated in pharyngeal discoordination, esophageal and gastric motility/peristalsis impairment, chronic pain, altered intestinal permeability and autonomic dysfunction of the colon, with subsequent constipation...
March 24, 2022: NPJ Parkinson's Disease
https://read.qxmd.com/read/35123355/the-use-of-cough-peak-flow-in-the-assessment-of-respiratory-function-in-clinical-practice-a-narrative-literature-review
#37
REVIEW
M Brennan, M J McDonnell, N Duignan, F Gargoum, R M Rutherford
Cough peak flow (CPF) is a useful clinical measurement to assess neuromuscular activity and effective coordination, yet it is rarely used in clinical practice outside of the management of patients with neuromuscular disorders. A CPF of above 160 L/min is required for an effective cough and less than 270 L/min is associated with increased secretion retention and risk of infection. Reduced CPF can be due to a number of mechanisms including reduced respiratory muscle strength, lack of co-ordination of glottic closure and opening, airway obstruction and, age and activity related changes...
March 2022: Respiratory Medicine
https://read.qxmd.com/read/34965177/a-case-of-v180i-genetic-mutation-creutzfeldt-jakob-disease-cjd-with-delusional-misidentification-as-an-initial-symptom
#38
JOURNAL ARTICLE
Tomoyuki Nagata, Shunichiro Shinagawa, Nobuyuki Kobayashi, Kazuhiro Kondo, Masahiro Shigeta
An 84-year-old woman who had been diagnosed as having dementia with Lewy body (DLB) upon initial examination exhibited cognitive impairments and person delusional misidentification (DMS): she transiently claimed that her spouse was a stranger. She was re-examined at the age of 89 years; her frequency of speech and activities of daily living had both decreased, leading to verbal communication difficulties complicated by sensory aphasia, and brain diffusion-weighted (DW) magnetic resonance imaging (MRI) showed cortical hyperintensities in some areas of both hemispheres...
December 2022: Prion
https://read.qxmd.com/read/34890260/effectiveness-of-interventions-for-dysphagia-in-parkinson-disease-a-systematic-review
#39
JOURNAL ARTICLE
Pooja Gandhi, Catriona M Steele
PURPOSE: Dysphagia is a common sequela of Parkinson disease (PD) and is associated with malnutrition, aspiration pneumonia, and mortality. This review article synthesized evidence regarding the effectiveness of interventions for dysphagia in PD. METHOD: Electronic searches were conducted in Ovid MEDLINE, Embase, Cochrane Central Register of Controlled Trials, CINAHL, and speechBITE. Of the 2,015 articles identified, 26 met eligibility criteria: interventional or observational studies with at least five or more participants evaluating dysphagia interventions in adults with PD-related dysphagia, with outcomes measured using videofluoroscopic swallowing study (VFSS), fiberoptic endoscopic evaluation of swallowing (FEES), or electromyography (EMG)...
December 10, 2021: American Journal of Speech-language Pathology
https://read.qxmd.com/read/34632001/sars-cov-19-associated-with-aspiration-pneumonia-in-a-patient-with-parkinson-disease-a-case-report
#40
Safaa Touihmi, Adam El Hassouni, Ilham Rkain
Coronaviruses can cause multiple systemic infections respiratory complications are the most recognizable symptoms similar to severe acute respiratory syndrome coronavirus (SARS-CoV). Aspiration pneumonia was the most common reason for the Emergency admission of patients with PD.Here we report the case a patient with Parkinson's disease admitted for respiratory insufficiency secondary to Covid-19 and aspiration pneumonia. A 78-years- old male patient, treated for Parkinson's disease, was admitted to the emergency department with symptoms of acute respiratory insufficiency...
2021: European Journal of Radiology Open
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