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https://www.readbyqxmd.com/read/29035884/protective-effects-of-pretreatment-with-quercetin-against-lipopolysaccharide-induced-apoptosis-and-the-inhibition-of-osteoblast-differentiation-via-the-mapk-and-wnt-%C3%AE-catenin-pathways-in-mc3t3-e1-cells
#1
Chun Guo, Rui-Juan Yang, Ke Jang, Xiao-Ling Zhou, Yu-Zhen Liu
BACKGROUND/AIMS: Quercetin, a flavonoid found in onions and other vegetables, has potential inhibitory effects on bone resorption in vivo and in vitro. In our previous study, we found that quercetin treatment reversed lipopolysaccharide (LPS)-induced inhibition of osteoblast differentiation through the mitogen-activated protein kinase (MAPK) pathway in MC3T3-E1 cells. In this study, we investigated the underlying mechanisms of pretreatment with quercetin on apoptosis and the inhibition of osteoblast differentiation in MC3T3-E1 cells induced by LPS...
October 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29035881/activation-of-signaling-cascades-by-weak-extremely-low-frequency-electromagnetic-fields
#2
Einat Kapri-Pardes, Tamar Hanoch, Galia Maik-Rachline, Manuel Murbach, Patricia L Bounds, Niels Kuster, Rony Seger
BACKGROUND/AIMS: Results from recent studies suggest that extremely low frequency magnetic fields (ELF-MF) interfere with intracellular signaling pathways related to proliferative control. The mitogen-activated protein kinases (MAPKs), central signaling components that regulate essentially all stimulated cellular processes, include the extracellular signal-regulated kinases 1/2 (ERK1/2) that are extremely sensitive to extracellular cues. Anti-phospho-ERK antibodies serve as a readout for ERK1/2 activation and are able to detect minute changes in ERK stimulation...
October 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29034730/corydaline-inhibits-enterovirus-71-replication-by-regulating-cox-2-expression
#3
Hui-Qiang Wang, Jin Hu, Hai-Yan Yan, Shuo Wu, Yu-Huan Li
Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro...
October 15, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29034071/apigenin-in-cancer-therapy-anti-cancer-effects-and-mechanisms-of-action
#4
REVIEW
Xiaohui Yan, Miao Qi, Pengfei Li, Yihong Zhan, Huanjie Shao
Apigenin is a common dietary flavonoid that is abundantly present in many fruits, vegetables and Chinese medicinal herbs and serves multiple physiological functions, such as strong anti-inflammatory, antioxidant, antibacterial and antiviral activities and blood pressure reduction. Therefore, apigenin has been used as a traditional medicine for centuries. Recently, apigenin has been widely investigated for its anti-cancer activities and low toxicity. Apigenin was reported to suppress various human cancers in vitro and in vivo by multiple biological effects, such as triggering cell apoptosis and autophagy, inducing cell cycle arrest, suppressing cell migration and invasion, and stimulating an immune response...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29032172/lps-enhances-expression-of-cd204-through-the-mapk-erk-pathway-in-murine-bone-marrow-macrophages
#5
Ryota Hashimoto, Ryo Kakigi, Kyoko Nakamura, Seigo Itoh, Hiroyuki Daida, Takao Okada, Youichi Katoh
BACKGROUND AND AIMS: Lipopolysaccharide (LPS) is a main component of the Gram-negative bacterial cell wall and is associated with a greater risk of atherosclerosis development in periodontal disease. LPS has been reported to increase both CD36 and CD204 expression and enhance the uptake of modified low-density lipoprotein (LDL). However, the signaling pathways by which LPS enhances these expression levels and function have not been fully elucidated, although the clarification of these signaling pathways is important for identifying therapeutic targets for atherosclerosis...
October 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29031211/cyanidin-3-o-glucoside-inhibits-the-uvb-induced-ros-cox-2-pathway-in-hacat-cells
#6
Yong He, Yunfeng Hu, Xinwei Jiang, Tianfeng Chen, Yuetang Ma, Shi Wu, Jianxia Sun, Rui Jiao, Xiaoling Li, Liehua Deng, Weibin Bai
Ultraviolet (UV) radiation from sunlight, especially UVB (290-320nm), is one of the most important environmental factors that destroys the integrity of the skin and causes epidermal cell apoptosis, potentially even leading to skin cancer. UVB irradiation can cause skin damage by stimulating inflammatory and apoptotic pathways. Anthocyanins are flavonoids that are common in many vegetable foods, and have also demonstrated chemopreventive effects. Cyanidin-3-O-glucoside, as a typical anthocyanin, exhibits anti-inflammatory and anti-oxidant effects...
October 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29031204/ginkgetin-inhibits-growth-of-breast-carcinoma-via-regulating-mapks-pathway
#7
Jun Cao, Chuang Tong, Yanyan Liu, Jianguo Wang, Xiaoyan Ni, Mao-Ming Xiong
The purpose of present study was to investigate anti-tumor activity of Ginkgetin (GK) and its mechanism of action in breast cancer. The effects of GK on growth of human breast cancer cell lines MDA-MB-231, BT-474 and MCF-7 were examined by MTT assay. Cells apoptosis in MCF-7 cells were analyzed by TUNEL staining and annexin-V and propidium iodide double staining. The effects of GK on expression of apoptotic associated proteins and mitogen-activated protein kinases (MAPKs) were determined by western blotting...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29029310/fragrance-allergens-linalool-and-limonene-allylic-hydroperoxides-in-skin-allergy-mechanisms-of-action-focusing-on-transcription-factor-nrf2
#8
Chloé Raffalli, Elodie Clouet, Salen Kuresepi, Marie-Hélène Damiens, Jean-Pierre Lepoittevin, Marc Pallardy, Pierre-Jacques Ferret, Elena Giménez-Arnau, Saadia Kerdine-Römer
Allergic contact dermatitis (ACD) is regarded as the most frequent expression of immunotoxicity in humans. Many odorant terpenes commonly used in fragrance compositions are considered as weak skin sensitizers, whereas some of their autoxidation products, allylic hydroperoxides, are classified as strong sensitizers according to the Local Lymph Node Assay (LLNA). However, the mechanism of their effects on the immune system remains unclear. Since dendritic cells play a key role in ACD, we studied their activation by the frequently used linalool (LINA) and limonene (LIMO), and their respective sensitizing allylic hydroperoxides (LINA-OOH, LIMO-OOH)...
September 29, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29027701/cellular-and-molecular-characterization-of-idh1-mutated-diffuse-low-grade-gliomas-reveals-tumor-heterogeneity-and-absence-of-egfr-pdgfr%C3%AE-activation
#9
S Azar, N Leventoux, C Ripoll, V Rigau, C Gozé, F Lorcy, L Bauchet, H Duffau, P O Guichet, B Rothhut, J P Hugnot
Diffuse low grade gliomas (DLGG, grade II gliomas) are slowly-growing brain tumors that often progress into high grade gliomas. Most tumors have a missense mutation for IDH1 combined with 1p19q codeletion in oligodendrogliomas or ATRX/TP53 mutations in astrocytomas. The phenotype of tumoral cells, their environment and the pathways activated in these tumors are still ill-defined and are mainly based on genomics and transcriptomics analysis. Here we used freshly-resected tumors to accurately characterize the tumoral cell population and their environment...
October 13, 2017: Glia
https://www.readbyqxmd.com/read/29027437/-rhaponticum-uniflorum-inhibits-h2o2-induced-apoptosis-of-liver-cells-via-jnk-and-nf-%C3%AE%C2%BAb-pathways
#10
Xin He, Chun-Yan Liu, Ji-Feng Yin, Ai-Hua Jin, Xue-Zhe Yin, Ji-Shu Quan
To study the inhibitory effect of Rhaponticum uniflorum on apoptosis induced by H2O2 in HepG2 cells. Human HepG2 cells injury models were established by H2O2, then cell survival rate was assayed by MTT method; levels of LDH, ALT, and AST were detected by chemical colorimetric method;SOD activity was detected by xanthine oxidase method; GSH content was detected by dithio-bis-nitrobenzoic acid(DTNB); MDA level was detected by thiobarbituric acid (TBA) method;and the relative activities of Caspase-3, 8 and 9 were measured by Colorimetry...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29027433/-inhibitory-mechanisms-of-timosaponin-a%C3%A2-on-proliferation-and-growth-of-human-glioblastoma-cells
#11
Xi Tan, Hui-Jun Pan, Wei-da Wu, Dan-Dan Zhang
To explore the inhibitory effect of timosaponin AⅢ on the proliferation of human glioblastoma cell line U87MG and investigate its related mechanism. As compared with the model group, the tumor weight was significantly reduced in timosaponin AⅢ-treated group. Timosaponin AⅢinhibited the proliferation of U87MG cell line in a dose-dependent manner. It up-regulated the gene and protein expression levels of p21, meanwhile inhibited the protein expression levels of β-Catenin, Cyclin D1 and Bcl-2. It also inhibited the translocation of β-Catenin into nucleus, suppressed the phosphorylation expression of ERK, but increased the phosphorylation expression of p38 and JNK...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29025731/macrophage-depletion-using-clodronate-liposomes-decreases-tumorigenesis-and-alters-gut-microbiota-in-the-aom-dss-mouse-model-of-colon-cancer
#12
Jackie E Bader, Reilly T Enos, Kandy T Velazquez, Meredith S Carson, Mitzi Nagarkatti, Prakash S Nagarkatti, Ioulia Chatzistamou, J Mark Davis, James A Carson, Cory Robinson, E Angela Murphy
We examined the role of macrophages in inflammation associated colorectal cancer (CRC). Given the emerging evidence on immune-microbiota interactions in CRC, we also sought to examine the interaction between macrophages and gut microbiota. To induce CRC, male C57BL/6 mice (n=32) received a single injection of azoxymethane (AOM) followed by three cycles of dextran sodium sulfate (DSS) supplemented water at weeks 1, 4, and 7, respectively. Prior to the final DSS cycle (week 7) and twice weekly until sacrifice, mice (n=16/group) received either 200μl i...
October 12, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29018425/phosphorylation-of-icariin-can-alleviate-the-oxidative-stress-caused-by-the-duck-hepatitis-virus-a-through-mitogen-activated-protein-kinases-signaling-pathways
#13
Wen Xiong, Wei Zhang, Wenjuan Yuan, Hongxu Du, Ke Ming, Fangke Yao, Jingying Bai, Yun Chen, Jiaguo Liu, Deyun Wang, Yuanliang Hu, Yi Wu
The duck virus hepatitis (DVH) caused by the duck hepatitis virus A (DHAV) has produced extensive economic losses to the duck industry. The currently licensed commercial vaccine has shown some defects and does not completely prevent the DVH. Accordingly, a new alternative treatment for this disease is urgently needed. Previous studies have shown that icariin (ICA) and its phosphorylated derivative (pICA) possessed good anti-DHAV effects through direct and indirect antiviral pathways, such as antioxidative stress...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29017756/biomechanical-strain-induced-modulation-of-proliferation-coincides-with-an-erk1-2-independent-nuclear-yap-localization
#14
Diana Huelter-Hassler, Martin Wein, Simon D Schulz, Susanne Proksch, Thorsten Steinberg, Britta A Jung, Pascal Tomakidi
Biomechanical strain induces activation of the transcriptional co-activator yes-associated protein (YAP) by nuclear re-distribution. Recent findings indicate that the mechanically responsive mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK) 1/2 is involved in the amount of nuclear YAP, reflecting its activation. In this context, we conducted experiments to detect how biomechanical strain acts on the subcellular localization of YAP in periodontal cells. To this end, cells were subjected to 2...
October 7, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29017559/salidroside-protects-against-foam-cell-formation-and-apoptosis-possibly-via-the-mapk-and-akt-signaling-pathways
#15
Jing Ni, Yuanmin Li, Weiming Li, Rong Guo
BACKGROUND: Foam cell formation and apoptosis are closely associated with atherosclerosis pathogenesis. We determined the effect of salidroside on oxidized low-density lipoprotein (ox-LDL)-induced foam cell formation and apoptosis in THP1 human acute monocytic leukemia cells and investigated the associated molecular mechanisms. METHODS: THP1-derived macrophages were incubated with salidroside for 5 h and then exposed to ox-LDL for 24 h to induce foam cell formation...
October 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29017538/hgf-potentiates-extracellular-matrix-driven-migration-of-human-myoblasts-involvement-of-matrix-metalloproteinases-and-mapk-erk-pathway
#16
Mariela Natacha González, Wallace de Mello, Gillian S Butler-Browne, Suse Dayse Silva-Barbosa, Vincent Mouly, Wilson Savino, Ingo Riederer
BACKGROUND: The hepatocyte growth factor (HGF) is required for the activation of muscle progenitor cells called satellite cells (SC), plays a role in the migration of proliferating SC (myoblasts), and is present as a soluble factor during muscle regeneration, along with extracellular matrix (ECM) molecules. In this study, we aimed at determining whether HGF is able to interact with ECM proteins, particularly laminin 111 and fibronectin, and to modulate human myoblast migration. METHODS: We evaluated the expression of the HGF-receptor c-Met, laminin, and fibronectin receptors by immunoblotting, flow cytometry, or immunofluorescence and used Transwell assays to analyze myoblast migration on laminin 111 and fibronectin in the absence or presence of HGF...
October 10, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/28993995/pi3k-akt-and-erk-mapk-signaling-promote-different-aspects-of-neuron-survival-and-axonal-regrowth-following-rat-facial-nerve-axotomy
#17
Haitao Huang, Huawei Liu, Rongzeng Yan, Min Hu
The ERK/MAPK and PI3K/Akt signaling pathways play important role in neuronal survival and axonal regeneration after peripheral nerve injury. However, the relative importance and degree of functional overlap of the two pathways are still debated due to lack of in-vivo data. We used rats which underwent a facial nerve axotomy, and examined subsequent ERK/MAPK and PI3K/Akt signaling activity by quantifying phosphorylation of ERK and Akt. We also assessed the survival rate of facial neurons, number of regenerated axons, and the length of axonal regrowth in axotomized animals treated with an inhibitor of ERK/MAPK (U0126) or PI3K/Akt (LY294002) phosphorylation, or with vehicle...
October 9, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28993776/human-cytomegalovirus-delays-neutrophil-apoptosis-and-stimulates-the-release-of-a-prosurvival-secretome
#18
Joanna M Pocock, Daniel M L Storisteanu, Matthew B Reeves, Jatinder K Juss, Mark R Wills, Andrew S Cowburn, Edwin R Chilvers
Human cytomegalovirus (HCMV) is a major cause of viral disease in the young and the immune-suppressed. At sites of infection, HCMV recruits the neutrophil, a cell with a key role in orchestrating the initial immune response. Herein, we report a profound survival response in human neutrophils exposed to the clinical HCMV isolate Merlin, but not evident with the attenuated strain AD169, through suppression of apoptosis. The initial survival event, which is independent of viral gene expression and involves activation of the ERK/MAPK and NF-κB pathways, is augmented by HCMV-stimulated release of a secretory cytokine profile that further prolongs neutrophil lifespan...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28993690/spred2-deficiecy-protects-mice-from-polymicrobial-septic-peritonitis-by-enhancing-inflammation-and-bacterial-clearance
#19
Junya Itakura, Miwa Sato, Toshihiro Ito, Megumi Mino, Soichiro Fushimi, Sakuma Takahashi, Teizo Yoshimura, Akihiro Matsukawa
Sepsis is an infection-induced systemic inflammatory syndrome and a major cause of death for critically ill patients. Here, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences host defense against polymicrobial sepsis (PMS) induced by cecal ligation and puncture (CLP). Compared to wild-type mice, Spred2(-/-) mice exhibited higher survival rates with increased level of leukocyte infiltration and local chemokine production and reduced plasma and peritoneal bacterial loads after CLP...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28993193/%C3%AE-lipoic-acid-inhibits-human-lung-cancer-cell-proliferation-through-grb2-mediated-egfr-downregulation
#20
Lan Yang, Ya Wen, Guoqing Lv, Yuntao Lin, Junlong Tang, Jingxiao Lu, Manqiao Zhang, Wen Liu, Xiaojuan Sun
BACKGROUND: Alpha lipoic acid (α -LA) is a naturally occurring antioxidant and metabolic enzyme co-factor. Recently, α -LA has been reported to inhibit the growth of various cancer cells, but the precise signaling pathways that mediate the effects of α -LA on non-small cell lung cancer (NSCLC) development remain unclear. METHODS: The CCK-8 assay was used to assess cell proliferation in NSCLC cell lines after α -LA treatment. The expression of growth factor receptor-bound protein 2 (Grb2), cyclin-dependent kinase (CDK)-2, CDK4, CDK6, Cyclin D3, Cyclin E1, Ras, c-Raf, epidermal growth factor receptor (EGFR), ERK1/2 and activated EGFR and ERK1/2 was evaluated by western blotting...
October 6, 2017: Biochemical and Biophysical Research Communications
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