keyword
MENU ▼
Read by QxMD icon Read
search

Generation gap

keyword
https://www.readbyqxmd.com/read/29166917/collaborative-action-for-person-centred-coordinated-care-p3c-an-approach-to-support-the-development-of-a-comprehensive-system-wide-solution-to-fragmented-care
#1
Helen M Lloyd, Mark Pearson, Rod Sheaff, Sheena Asthana, Hannah Wheat, Thava Priya Sugavanam, Nicky Britten, Jose Valderas, Michael Bainbridge, Louise Witts, Debra Westlake, Jane Horrell, Richard Byng
BACKGROUND: Fragmented care results in poor outcomes for individuals with complexity of need. Person-centred coordinated care (P3C) is perceived to be a potential solution, but an absence of accessible evidence and the lack of a scalable 'blue print' mean that services are 'experimenting' with new models of care with little guidance and support. This paper presents an approach to the implementation of P3C using collaborative action, providing examples of early developments across this programme of work, the core aim of which is to accelerate the spread and adoption of P3C in United Kingdom primary care settings...
November 22, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29166858/adage-signature-analysis-differential-expression-analysis-with-data-defined-gene-sets
#2
Jie Tan, Matthew Huyck, Dongbo Hu, René A Zelaya, Deborah A Hogan, Casey S Greene
BACKGROUND: Gene set enrichment analysis and overrepresentation analyses are commonly used methods to determine the biological processes affected by a differential expression experiment. This approach requires biologically relevant gene sets, which are currently curated manually, limiting their availability and accuracy in many organisms without extensively curated resources. New feature learning approaches can now be paired with existing data collections to directly extract functional gene sets from big data...
November 22, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29165439/proteomic-signatures-differentiating-bacillus-anthracis-sterne-sporulation-on-soil-relative-to-laboratory-media
#3
D S Wunschel, J R Hutchison, B L Deatherage Kaiser, E D Merkley, B M Hess, A Lin, M G Warner
The process of sporulation is vital for the stability and infectious cycle of Bacillus anthracis. The spore is the infectious form of the organism and therefore relevant to biodefense. While the morphological and molecular events occurring during sporulation have been well studied, the influence of growth medium and temperature on the proteins expressed in sporulated cultures is not well understood. Understanding the features of B. anthracis sporulation specific to natural vs. laboratory production will address an important question in microbial forensics...
November 22, 2017: Analyst
https://www.readbyqxmd.com/read/29165009/the-physical-digital-divide-exploring-the-social-gap-between-digital-natives-and-physical-natives
#4
Christopher Ball, Jessica Francis, Kuo-Ting Huang, Travis Kadylak, Shelia R Cotten, R V Rikard
Older adults are the most digitally divided demographic group. The present study explores how older adults perceive the physical use of information and communication technologies (ICTs), particularly across generations and contexts. Data for the present study come from nine focus groups. Seniors acknowledge that ICTs help them connect with geographically distant social ties, but that they lead to feelings of disconnection with geographically close social ties. We label this phenomenon the "physical-digital divide," which exists when a group feels ostracized or offended when those around them engage with ICTs while they themselves are not or cannot engage with ICTs...
September 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29164478/excited-state-and-non-linear-optical-properties-of-nir-absorbing-%C3%AE-thiophene-fused-bf2-azadipyrromethene-dyes-computational-investigation
#5
Yogesh Gawale, Lydia Rhyman, Mohamed I Elzagheid, Ponnadurai Ramasami, Nagaiyan Sekar
Density functional theory and time-dependent density functional theory computations were used to understand the electronic and photophysical parameters of NIR β-thiophene-fused BF2-azadipyrromethene dyes. The computed data are in good agreement with those obtained experimentally and they provide insights into the origin of red shifted optical spectra compared to the parent aza-BODIPY, low Stokes shift, non-linear optical responses and quantitative description of the singlet-triplet energy gap. The resultant decrease in the HOMO - LUMO energy gap is responsible for the red shift...
November 21, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/29163936/quality-of-antenatal-care-service-provision-in-health-facilities-across-sub-saharan-africa-evidence-from-nationally-representative-health-facility-assessments
#6
Mufaro Kanyangarara, Melinda K Munos, Neff Walker
Background: Utilization of antenatal care (ANC) services has increased over the past two decades. Continued gains in maternal and newborn health will require an understanding of both access and quality of ANC services. We linked health facility and household survey data to examine the quality of service provision for five ANC interventions across health facilities in sub-Saharan Africa. Methods: Using data from 20 nationally representative health facility assessments - the Service Provision Assessment (SPA) and the Service Availability and Readiness Assessment (SARA), we estimated facility level readiness to deliver five ANC interventions: tetanus toxoid vaccine for pregnant women, intermittent preventive treatment for malaria in pregnancy (IPTp), syphilis detection and treatment in pregnancy, iron supplementation and hypertensive disease case management...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29163229/cx43-isoform-gja1-20k-promotes-microtubule-dependent-mitochondrial-transport
#7
Ying Fu, Shan-Shan Zhang, Shaohua Xiao, Wassim A Basheer, Rachel Baum, Irina Epifantseva, TingTing Hong, Robin M Shaw
Connexin 43 (Cx43, encoded by GJA1) is a cell-cell communication gap junction protein expressed in all organ systems. It was recently found that GJA1 mRNA undergoes alternative translation to generate N-terminal truncated isoforms, of which GJA1-20k is the most abundant. Here we report a surprising finding that, unlike full length GJA1-43k, GJA1-20k has a strong tropism for mitochondria. Exploring function, we found that GJA1-20k appears to be an organelle chaperone and that overexpression of GJA1-20k is sufficient to rescue mitochondrial localization to the cell periphery upon exposure to hydrogen peroxide, which effectively limits the network fragmentation that occurs with oxidative stress...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162844/dna-nanomapping-using-crispr-cas9-as-a-programmable-nanoparticle
#8
Andrey Mikheikin, Anita Olsen, Kevin Leslie, Freddie Russell-Pavier, Andrew Yacoot, Loren Picco, Oliver Payton, Amir Toor, Alden Chesney, James K Gimzewski, Bud Mishra, Jason Reed
Progress in whole-genome sequencing using short-read (e.g., <150 bp), next-generation sequencing technologies has reinvigorated interest in high-resolution physical mapping to fill technical gaps that are not well addressed by sequencing. Here, we report two technical advances in DNA nanotechnology and single-molecule genomics: (1) we describe a labeling technique (CRISPR-Cas9 nanoparticles) for high-speed AFM-based physical mapping of DNA and (2) the first successful demonstration of using DVD optics to image DNA molecules with high-speed AFM...
November 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/29162321/a-cluster-randomized-trial-to-determine-the-effectiveness-of-a-novel-digital-pendant-and-voice-reminder-platform-on-increasing-infant-immunization-adherence-in-rural-udaipur-india
#9
Ruchit Nagar, Preethi Venkat, Logan D Stone, Kyle A Engel, Praneeth Sadda, Mohammed Shahnawaz
BACKGROUND: Five hundred thousand children under the age of 5 die from vaccine preventable diseases in India every year. More than just improving coverage, increasing timeliness of immunizations is critical to ensuring infant health in the first year of life. Novel, culturally appropriate community engagement strategies are worth exploring to close the immunization gap. In our study, a digital NFC (Near Field Communication) pendant worn on black thread and voice call reminder system was tested for the effectiveness in improving DTP3 adherence within 2 monthly camps from DTP1 administration...
November 18, 2017: Vaccine
https://www.readbyqxmd.com/read/29161764/mechanism-of-doxorubicin-cardiotoxicity-evaluated-by-integrating-multiple-molecular-effects-into-a-biophysical-model
#10
M Fernandez-Chas, M J Curtis, S A Niederer
BACKGROUND AND PURPOSE: Doxorubicin (DOX) is an effective cancer therapeutic agent but causes therapy-limiting cardiotoxicity. The effects of DOX and its metabolite doxorubicinol (DOXL) on individual channels have been well characterised in isolation. However, it is unknown how the action and interaction of affected channels combine to generate the phenotypic cardiotoxic outcome. We sought to develop an in silico model that links drug effects on channels to action potential duration (APD) and intracellular Ca(2+) concentration in order to address this gap in knowledge...
November 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29161154/effects-of-gloves-and-pulling-task-on-achievable-downward-pull-forces-on-a-rung
#11
Kurt E Beschorner, Gregory P Slota, Erika M Pliner, Egli Spaho, Na Jin Seo
Objective We examined the impacts of pulling task (breakaway and pull-down tasks at different postures), glove use, and their interaction on achievable downward pull forces from a ladder rung. Background Posture, glove use, and the type of pulling task are known to affect the achievable forces. However, a gap in the literature exists regarding how these factors affect achievable downward pulling forces, which are relevant to recovery from a perturbation during ladder climbing. Methods Forty subjects completed four downward pulling tasks (breakaway force; pull force at maximum height, shoulder height, and a middle height), using three glove conditions with varying coefficient of friction (COF) levels (cotton glove, low COF; bare hand, moderate COF; and latex-coated glove, high COF) with their dominant and nondominant hand...
November 1, 2017: Human Factors
https://www.readbyqxmd.com/read/29160162/is-college-education-an-equalizer-for-social-disparities-in-health-literacy-a-case-study-in-shanghai-china
#12
Anning Hu, Xiaozhao Yousef Yang
OBJECTIVES: The aim of the study was to illustrate the immediate effect of the college education process (across college grades) on the strength of association between parental education and college attendees' health literacy. METHODS: Cross-sectional analysis was conducted based on data from a random sample of students in one university in Shanghai, China ( N = 574). Exploratory factor analysis was used to generate factors of different dimensions of health literacy...
November 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/29160024/a-conceptual-framework-for-understanding-the-perspectives-on-the-causes-of-the-science-practice-gap-in-ecology-and-conservation
#13
Diana Bertuol-Garcia, Carla Morsello, Charbel N El-Hani, Renata Pardini
Applying scientific knowledge to confront societal challenges is a difficult task, an issue known as the science-practice gap. In Ecology and Conservation, scientific evidence has been seldom used directly to support decision-making, despite calls for an increasing role of ecological science in developing solutions for a sustainable future. To date, multiple causes of the science-practice gap and diverse approaches to link science and practice in Ecology and Conservation have been proposed. To foster a transparent debate and broaden our understanding of the difficulties of using scientific knowledge, we reviewed the perceived causes of the science-practice gap, aiming to: (i) identify the perspectives of ecologists and conservation scientists on this problem, (ii) evaluate the predominance of these perspectives over time and across journals, and (iii) assess them in light of disciplines studying the role of science in decision-making...
November 20, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29159356/influence-of-the-anatase-rutile-ratio-on-the-charge-transport-properties-of-tio2-nts-arrays-studied-by-dual-wavelength-opto-electrochemical-impedance-spectroscopy
#14
T Cottineau, H Cachet, V Keller, E M M Sutter
The modification of photo-generated charge transport properties in aligned titanium dioxide nanotubes (TiO2-NTs) regarding the anatase/rutile ratio was studied by photo-electrochemical methods. TiO2-NTs obtained by anodization were thermally treated under air flux at different temperatures to significantly modify the proportion of TiO2 anatase and rutile phases in the tubular structure. Material characterisation methods (XRD, SEM, UV-visible spectroscopy) were used to determine the characteristics of the different TiO2-NT electrodes in terms of dimensions, proportion of each phase and optical properties...
November 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29157743/next-generation-microbiological-risk-assessment-meta-omics-the-next-need-for-integration
#15
Luca Cocolin, Marios Mataragas, Francois Bourdichon, Agapi Doulgeraki, Marie-France Pilet, Balamurugan Jagadeesan, Kalliopi Rantsiou, Trevor Phister
The development of a multi-omics approach has provided a new approach to the investigation of microbial communities allowing an integration of data, which can be used to better understand the behaviour of and interactions between community members. Metagenomics, metatranscriptomics, metaproteomics and metabolomics have the potential of producing a large amount of data in a very short time, however an important challenge is how to exploit and interpret these data to assist risk managers in food safety and quality decisions...
November 13, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29155561/fabrication-of-csxfa1-xpbi3-mixed-cation-perovskites-via-gas-phase-assisted-compositional-modulation-for-efficient-and-stable-photovoltaic-devices
#16
Paifeng Luo, Shengwen Zhou, Yugang Zhou, Wei Xia, Lin Sun, Jigui Cheng, Chenxi Xu, Yingwei Lu
Over the past few years, significant attention has been focused on HC(NH2)2PbI3 (FAPbI3) perovskite due to their reduced band gap and enhanced thermal stability compared with the most studied CH3NH3PbI3 (MAPbI3). However, FAPbI3 is sensitive to moisture and also encounters serious structural phase-transition from photoactive -phase to photoinactive -phase. Herein, we first develop a novel FAI gas-phase assisted mixed-cation compositional modulation method to fabricate CsxFA1-xPbI3 perovskite solar cells (PSCs), and realize the structural stabilization of -phase FAPbI3 with the incorporation of smaller inorganic Cs+ ions...
November 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29155288/investigation-of-the-practices-legislation-supply-chain-and-regulation-of-opioids-for-clinical-pain-management-in-southern-africa-a-multi-sectoral-cross-national-mixed-methods-study
#17
Eve Namisango, Matthew J Allsop, Richard A Powell, Stefan J Friedrichsdorf, Emmanuel Bk Luyirika, Fatia Kiyange, Edward Mukooza, Chris Ntege, Eunice Garanganga, Mavis Ntombifuthi Ginindza-Mdluli, Faith Mwangi-Powell, Lidia Justino Mondlane, Richard Harding
CONTEXT: Sub-Saharan Africa faces an increasing incidence and prevalence of life-limiting and life-threatening conditions. These conditions are associated with a significant burden of pain linked to high morbidity and disability that is poorly assessed and undertreated. Barriers to effective pain management partly relate to lack of access to opioid analgesia and challenges in their administration. OBJECTIVES: To identify country-specific and broader regional barriers to access, as well as the administration of opioids, and generate recommendations for advancing pain management in Southern Africa...
November 15, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29151145/pendimethalin-induces-oxidative-stress-dna-damage-and-mitochondrial-dysfunction-to-trigger-apoptosis-in-human-lymphocytes-and-rat-bone-marrow-cells
#18
Sabiha M Ansari, Quaiser Saquib, Sabry M Attia, Eslam M Abdel-Salam, Hend A Alwathnani, Mohammad Faisal, Abdulrahman A Alatar, Abdulaziz A Al-Khedhairy, Javed Musarrat
Pendimethalin (PM) is a dinitroaniline herbicide extensively applied against the annual grasses and broad-leaved weeds. There is no report available on PM-induced low-dose genotoxicity in human primary cells and in vivo test models. Such data gap has prompted us to evaluate the genotoxic potential of PM in human lymphocytes and rats. PM selectively binds in the minor groove of DNA by forming covalent bonds with G and C nitrogenous bases, as well as with the ribose sugar. PM induces micronucleus formation (MN) in human lymphocytes, indicating its clastogenic potential...
November 18, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29149200/heterozygous-deletion-of-both-sclerostin-sost-and-connexin43-gja1-genes-in-mice-is-not-sufficient-to-impair-cortical-bone-modeling
#19
Susan K Grimston, Francesca Fontana, Marcus Watkins, Roberto Civitelli
Connexin43 (Cx43) is the main gap junction protein expressed in bone forming cells, where it modulates peak bone mass acquisition and cortical modeling. Genetic ablation of the Cx43 gene (Gja1) results in cortical expansion with accentuated periosteal bone formation associated with decreased expression of the Wnt inhibitor sclerostin. To determine whether sclerostin (Sost) down-regulation might contribute to periosteal expansion in Gja1 deficient bones, we took a gene interaction approach and crossed mice harboring germline null alleles for Gja1 or Sost to generate single Gja1+/-and Sost+/-and double Gja1+/-;Sost+/-heterozygous mice...
2017: PloS One
https://www.readbyqxmd.com/read/29147697/role-of-spin-orbit-interaction-on-the-nonlinear-optical-response-of-cspbco3f-using-dft
#20
E Narsimha Rao, G Vaitheeswaran, Ali H Reshak, S Auluck
We explore the effect of spin-orbit interaction (SOI) on the electronic and optical properties of CsPbCO3F using the full potential linear augmented plane wave method with the density functional theory (DFT) approach. CsPbCO3F is known for its high powder second harmonic generation (SHG) coefficient (13.4 times (d36 = 0.39 pm V(-1)) that of KH2PO4 (KDP)). Calculations are done for many exchange correlation (XC) potentials. After the inclusion of SOI, the calculated Tran-Blaha modified Becke-Johnson (TB-mBJ) band gap of 5...
November 17, 2017: Physical Chemistry Chemical Physics: PCCP
keyword
keyword
111733
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"