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https://www.readbyqxmd.com/read/28107992/designing-of-ordered-two-dimensional-gold-nanoparticles-film-for-cocaine-detection-in-human-urine-using-surface-enhanced-raman-spectroscopy
#1
Juan Meng, Xianghu Tang, Binbin Zhou, Qiwen Xie, Liangbao Yang
A novel and rapid method to detect cocaine in human urine has been developed by using self-assembly ordered two dimensional (2D) gold nanoparticles (GNPs) film as surface-enhanced Raman spectroscopy (SERS) substrates. In order to obtain high sensitivity, uniformity, and reproducibility of SERS platform, quasi-spherical, uniform GNPs were firstly synthesis using seed growth method, in which the GNPs have been functionalized with CTAB to form orderly close-packed GNPs film as SERS substrate. Importantly, the high-performance GNPs on solid substrates can produce a high yield of sub-10-nm gaps which can generate gigantic signals enhancement for analytes adsorbed GNPs surface...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28106265/effects-of-self-carbon-dioxide-generation-material-for-active-packaging-on-ph-water-holding-capacity-meat-color-lipid-oxidation-and-microbial-growth-in-beef-during-cold-storage
#2
Seung Jae Lee, Seung Yun Lee, Gap Don Kim, Geun Bae Kim, Sang Keun Jin, Sun Jin Hur
BACKGROUND: Active packaging refers to the mixing of additive agents into packagingmaterials with the purpose of hold or extending food product quality and shelf life. The purpose of this study was to develop an easy and cheap active packaging in beef. Beef loin samples were divided into 3 packaging groups (C: ziplock bag-packaging, T1: vacuum-packaging, T2: active-packaging) and stored at 4 °C for 21 days. RESULTS: The water-holding capacity was significantly (p < 0...
January 20, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28105946/a-physarum-inspired-prize-collecting-steiner-tree-approach-to-identify-subnetworks-for-drug-repositioning
#3
Yahui Sun, Pathima Nusrath Hameed, Karin Verspoor, Saman Halgamuge
BACKGROUND: Drug repositioning can reduce the time, costs and risks of drug development by identifying new therapeutic effects for known drugs. It is challenging to reposition drugs as pharmacological data is large and complex. Subnetwork identification has already been used to simplify the visualization and interpretation of biological data, but it has not been applied to drug repositioning so far. In this paper, we fill this gap by proposing a new Physarum-inspired Prize-Collecting Steiner Tree algorithm to identify subnetworks for drug repositioning...
December 5, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/28105921/simba-a-web-tool-for-managing-bacterial-genome-assembly-generated-by-ion-pgm-sequencing-technology
#4
Diego C B Mariano, Felipe L Pereira, Edgar L Aguiar, Letícia C Oliveira, Leandro Benevides, Luís C Guimarães, Edson L Folador, Thiago J Sousa, Preetam Ghosh, Debmalya Barh, Henrique C P Figueiredo, Artur Silva, Rommel T J Ramos, Vasco A C Azevedo
BACKGROUND: The evolution of Next-Generation Sequencing (NGS) has considerably reduced the cost per sequenced-base, allowing a significant rise of sequencing projects, mainly in prokaryotes. However, the range of available NGS platforms requires different strategies and software to correctly assemble genomes. Different strategies are necessary to properly complete an assembly project, in addition to the installation or modification of various software. This requires users to have significant expertise in these software and command line scripting experience on Unix platforms, besides possessing the basic expertise on methodologies and techniques for genome assembly...
December 15, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28104450/polymerases-of-paramyxoviruses-and-pneumoviruses
#5
REVIEW
Rachel Fearns, Richard K Plemper
The paramyxo- and pneumoviruses are members of the order Mononegavirales, a group of viruses with non-segmented, negative strand RNA genomes. The polymerases of these viruses are multi-functional complexes, capable of transcribing subgenomic capped and polyadenylated mRNAs and replicating the genome. Although there is no native structure available for any complete paramyxo- or pneumovirus polymerase, functional and structural studies of a fragment of a pneumovirus polymerase protein and mutation analyses and resistance profiling of small-molecule inhibitors have generated a wealth of mechanistic information...
January 16, 2017: Virus Research
https://www.readbyqxmd.com/read/28103120/compassionate-options-for-pediatric-ems-cope-addressing-communication-skills
#6
Aaron W Calhoun, Erica R H Sutton, Anita P Barbee, Beth McClure, Carrie Bohnert, Richard Forest, Peter Taillac, Mary E Fallat
INTRODUCTION: Each year, 16,000 children suffer cardiopulmonary arrest, and in one urban study, 2% of pediatric EMS calls were attributed to pediatric arrests. This indicates a need for enhanced educational options for prehospital providers that address how to communicate to families in these difficult situations. In response, our team developed a cellular phone digital application (app) designed to assist EMS providers in self-debriefing these events, thereby improving their communication skills...
January 19, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28102269/from-morphogen-to-morphogenesis-and-back
#7
Darren Gilmour, Martina Rembold, Maria Leptin
A long-term aim of the life sciences is to understand how organismal shape is encoded by the genome. An important challenge is to identify mechanistic links between the genes that control cell-fate decisions and the cellular machines that generate shape, therefore closing the gap between genotype and phenotype. The logic and mechanisms that integrate these different levels of shape control are beginning to be described, and recently discovered mechanisms of cross-talk and feedback are beginning to explain the remarkable robustness of organ assembly...
January 18, 2017: Nature
https://www.readbyqxmd.com/read/28102170/complication-of-a-femoral-fracture-treated-by-intramedullary-nailing-numerical-analysis-of-a-clinical-case
#8
Jakub J Słowiński, Konrad Kudłacik
The aim of this paper is to conduct a numerical analysis of a case of femoral fracture treated by intramedullary nailing and confirm the conditions which led to the formation of a pseudarthrosis at the fracture site. A low-energy femoral fracture was treated by placing a ChFN System intramedullary nail with a derotation pin. Using the finite element method, a bone-implant system was generated which made it possible to observe the displacement area and strains in the region of the fracture gap. The calculations were conducted for 3 variants of the model, using a titanium nail (10 mm and 12 mm) and a steel one (10 mm)...
August 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28101110/the-best-age-for-pregnancy-and-undue-pressures
#9
Carlo Bellieni
In western countries we assist at the paradox that fertility is socially discouraged by a mindset that depicts fertility as a resource to exploit as late as possible. So, couples have high expectative about the advantages of delayed parenthood, but they are scarcely informed about its risks. Scientific data suggests to anticipate the first pregnancy, but social pressures impose to wait, though delayed childbearing can provoke sterility and a greater gap between generations. The best age to become parents should be autonomously decided by a couple, under the condition of being a free informed choice and not a social imposition, but currently this is not guaranteed to western women and men...
September 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28100185/an-improved-genome-assembly-uncovers-prolific-tandem-repeats-in-atlantic-cod
#10
Ole K Tørresen, Bastiaan Star, Sissel Jentoft, William B Reinar, Harald Grove, Jason R Miller, Brian P Walenz, James Knight, Jenny M Ekholm, Paul Peluso, Rolf B Edvardsen, Ave Tooming-Klunderud, Morten Skage, Sigbjørn Lien, Kjetill S Jakobsen, Alexander J Nederbragt
BACKGROUND: The first Atlantic cod (Gadus morhua) genome assembly published in 2011 was one of the early genome assemblies exclusively based on high-throughput 454 pyrosequencing. Since then, rapid advances in sequencing technologies have led to a multitude of assemblies generated for complex genomes, although many of these are of a fragmented nature with a significant fraction of bases in gaps. The development of long-read sequencing and improved software now enable the generation of more contiguous genome assemblies...
January 18, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28099847/leukocytes-breach-endothelial-barriers-by-insertion-of-nuclear-lobes-and-disassembly-of-endothelial-actin-filaments
#11
Sagi Barzilai, Sandeep Kumar Yadav, Steven Morrell, Francesco Roncato, Eugenia Klein, Liat Stoler-Barak, Ofra Golani, Sara W Feigelson, Assaf Zemel, Sussan Nourshargh, Ronen Alon
The endothelial cytoskeleton is a barrier for leukocyte transendothelial migration (TEM). Mononuclear and polymorphonuclear leukocytes generate gaps of similar micron-scale size when squeezing through inflamed endothelial barriers in vitro and in vivo. To elucidate how leukocytes squeeze through these barriers, we co-tracked the endothelial actin filaments and leukocyte nuclei in real time. Nuclear squeezing involved either preexistent or de novo-generated lobes inserted into the leukocyte lamellipodia. Leukocyte nuclei reversibly bent the endothelial actin stress fibers...
January 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/28099474/dna-double-strand-breaks-induce-the-nuclear-actin-filaments-formation-in-cumulus-enclosed-oocytes-but-not-in-denuded-oocytes
#12
Ming-Hong Sun, Mo Yang, Feng-Yun Xie, Wei Wang, Lili Zhang, Wei Shen, Shen Yin, Jun-Yu Ma
As a gamete, oocyte needs to maintain its genomic integrity and passes this haploid genome to the next generation. However, fully-grown mouse oocyte cannot respond to DNA double-strand breaks (DSBs) effectively and it is also unable to repair them before the meiosis resumption. To compensate for this disadvantage and control the DNA repair events, oocyte needs the cooperation with its surrounding cumulus cells. Recently, evidences have shown that nuclear actin filament formation plays roles in cellular DNA DSB repair...
2017: PloS One
https://www.readbyqxmd.com/read/28099036/another-generation-of-stigma-assessing-healthcare-student-perceptions-of-hiv-positive-patients-in-mwanza-tanzania
#13
Sahil Aggarwal, Debora H Lee, William B Minteer, Reece T H Fenning, Shella K Raja, Megan E Bernstein, Kaavya R Raman, Sean P Denny, Priya A Patel, Mark Lieber, Allison O Farfel, Catherine A Diamond
HIV-related stigma remains a persistent global health concern among people living with HIV/AIDS (PLWA) in developing nations. The literature is lacking in studies about healthcare students' perceptions of PLWA. This study is the first effort to understand stigmatizing attitudes toward HIV-positive patients by healthcare students in Mwanza, Tanzania, not just those who will be directly treating patients but also those who will be indirectly involved through nonclinical roles, such as handling patient specimens and private health information...
January 18, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28098406/contemporary-migration-patterns-in-the-prevalence-of-helicobacter-pylori-infection-a-systematic-review
#14
REVIEW
Samantha Morais, Ana Rute Costa, Ana Ferro, Nuno Lunet, Bárbara Peleteiro
BACKGROUND: A rapid growth in the number of international migrants over the past years has occurred with most traveling to more affluent settings. As Helicobacter pylori infects over half of the adult population and its prevalence is higher in developing countries, understanding the prevalence of infection in migrants can provide insight into future trends in the burden and management of infection. We aimed to describe the prevalence of H. pylori among migrants through a systematic literature review...
January 18, 2017: Helicobacter
https://www.readbyqxmd.com/read/28098299/vacancies-in-functional-materials-for-clean-energy-storage-and-harvesting-the-perfect-imperfection
#15
Guowei Li, Graeme R Blake, Thomas T M Palstra
Vacancies exist throughout nature and determine the physical properties of materials. By manipulating the density and distribution of vacancies, it is possible to influence their physical properties such as band-gap, conductivity, magnetism, etc. This can generate exciting applications in the fields of water treatment, energy storage, and physical devices such as resistance-change memories. In this review, we focus on recent progress in vacancy engineering for the design of materials for energy harvesting applications...
January 18, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28097598/influence-of-doping-and-nanostructuration-on-n-type-bi2-te0-8se0-2-3-alloys-synthesized-by-arc-melting
#16
Mouna Gharsallah, Federico Serrano-Sanchez, Norbert M Nemes, Jose Luis Martinez, Jose Antonio Alonso
In competitive thermoelectric devices for energy conversion and generation, high-efficiency materials of both n-type and p-type are required. For this, Bi2Te3-based alloys have the best thermoelectric properties in room temperature applications. Partial replacement of tellurium by selenium is expected to introduce new donor states in the band gap, which would alter electrical conductivity and thermopower. We report on the preparation of n-type Bi2(Te1-xSex)3 solid solutions by a straightforward arc-melting technique, yielding nanostructured polycrystalline pellets...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28097211/new-generation-small-animal-positron-emission-tomography-system-for-molecular-imaging
#17
Shiva Abbaszadeh, Craig S Levin
The next generation of discoveries in molecular imaging requires positron emission tomography (PET) systems with high spatial resolution and high sensitivity to visualize and quantify low concentrations of molecular probes. The goal of this work is to assemble and explore such a system. We use cadmium zinc telluride (CZT) to achieve high spatial resolution, three-dimensional interaction positioning, and excellent energy resolution. The CZT crystals are arranged in an edge-on configuration with a minimum gap of [Formula: see text] in a four-sided panel geometry to achieve superior photon sensitivity...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28096490/comprehensive-essentiality-analysis-of-the-mycobacterium-tuberculosis-genome-via-saturating-transposon-mutagenesis
#18
Michael A DeJesus, Elias R Gerrick, Weizhen Xu, Sae Woong Park, Jarukit E Long, Cara C Boutte, Eric J Rubin, Dirk Schnappinger, Sabine Ehrt, Sarah M Fortune, Christopher M Sassetti, Thomas R Ioerger
: For decades, identifying the regions of a bacterial chromosome that are necessary for viability has relied on mapping integration sites in libraries of random transposon mutants to find loci that are unable to sustain insertion. To date, these studies have analyzed subsaturated libraries, necessitating the application of statistical methods to estimate the likelihood that a gap in transposon coverage is the result of biological selection and not the stochasticity of insertion. As a result, the essentiality of many genomic features, particularly small ones, could not be reliably assessed...
January 17, 2017: MBio
https://www.readbyqxmd.com/read/28095850/building-system-capacity-for-the-integration-of-mental-health-at-the-level-of-primary-care-in-tunisia-a-study-protocol-in-global-mental-health
#19
Jessica Spagnolo, François Champagne, Nicole Leduc, Myra Piat, Wahid Melki, Fatma Charfi, Marc Laporta
BACKGROUND: In low- and middle-income countries (LMICs), addressing the high prevalence of mental disorders is a challenge given the limited number and unequal distribution of specialists, as well as scarce resources allocated to mental health. The Mental Health Gap Action Programme (mhGAP) and its accompanying Intervention Guide (IG), developed by the World Health Organization (WHO), aim to address this challenge by training non-specialists such as general practitioners (GPs) in mental health care...
January 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28094990/bridging-the-gap-between-dielectric-nanophotonics-and-the-visible-regime-with-effectively-lossless-gap-antennas
#20
Javier Cambiasso, Gustavo Grinblat, Yi Li, Aliaksandra Rakovich, Emiliano Cortés, Stefan A Maier
We present all-dielectric gallium phosphide (GaP) nanoantennas as an efficient nanophotonic platform for surface-enhanced second harmonic generation (SHG) and fluorescence (SEF), showing negligible losses in the visible range. Employing single GaP nanodisks, we observe an increase of more than three orders of magnitude in the SHG signal in comparison with the bulk. This constitutes an SHG efficiency as large as 0.0002%, which is, to the best of our knowledge, the highest yet achieved value produced by a single nano-object in the optical region...
January 17, 2017: Nano Letters
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