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type 1 hyperlipoproteinaemia

Katsuyuki Nakajima, Masahiro Daimon, Kiyoshi Kamiyama, Kunihiko Takanashi, Yukiko Suzuki, Masakazu Watanabe, Katsuo Kubono, Abby R Saniabadi, Sei-ichi Takashima, Ikunosuke Sakurabayashi
BACKGROUND: An elevated serum remnant lipoprotein cholesterol (RLP-C)/triglyceride (TG) ratio has not been evaluated as an index of familial type III hyperlipidaemia defined by the presence of beta-VLDL and apolipoprotein (Apo) E2/2 phenotype in the Japanese hyperlipidaemic population. METHODS: Serum lipids and lipoproteins from 514 individuals (200 men and 314 women, mean age 58 years) with total cholesterol >6.22 mmol/L and TG between 2.26 mmol/L and 9.04 mmol/L, selected from 25,080 subjects visiting the clinics for health checkup were analysed for a possible relationship with familial type III hyperlipoproteinaemia...
July 2007: Annals of Clinical Biochemistry
G S Dave, K Kalia
Diabetes mellitus is associated with hyperglycemia, hyperlipoproteinaemia and oxidative stress at cellular level. The aim of the present study was to determine the relationship between anti-oxidative system of cells and hyperglycemia induced reactive oxygen species (ROS) in type-1 and type-2 diabetic patients with and without nephropathy. ROS are anihilated by an intracellular enzymatic system such as glutathione peroxidase (GPx) and catalase and the reduced glutathione (GSH) is the major antioxidant of erythrocytes and plasma...
2007: Cellular and Molecular Biology
C Otto, B Otto, R J A Frost, M Vogeser, A F H Pfeiffer, J Spranger, K G Parhofer
Lipid-lowering therapy is associated with reduced cardiovascular risk. The aim of the present study was to investigate whether lipid-lowering therapy might be associated with changes in the concentrations of metabolically important hormone concentrations. We performed a randomised cross-over open-label trial with atorvastatin (10 mg/day) and fenofibrate (200 mg/day), each for 6 weeks separated by a 6-week washout period in 13 patients (5 men, 8 women, age 60.0+/-6.8 years, body mass index 30.0+/-3.0 kg/m2) with type 2 diabetes mellitus and mixed hyperlipoproteinaemia...
June 2007: Acta Diabetologica
W Druml, K Widhalm, A Laggner, G Kleinberger, K Lenz
Lipid metabolism and elimination of parenterally administered fat were investigated in 15 patients with acute renal failure (ARF). The mean triglyceride level was elevated to 2.56 +/- 1.43 mmol/l and the mean cholesterol level was 3.32 +/- 0.66 mmol/l, which is slightly below the normal range. A type IV hyperlipoproteinaemia was present in 47 per cent of the patients. The triglyceride content of LDL and VLDL was elevated and the cholesterol concentration of HDL and of LDL was reduced markedly. The fractional removal rate of triglycerides (K2) evaluated by an intravenous fat tolerance test using a bolus technique was reduced to 2...
July 1982: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
J Perusicová
UNLABELLED: In a 10-year prospective study of a group of 314 newly manifested diabetics (1988-1991) aged 20-65 years the authors follow up the development of diabetic complications and therapeutic methods used in diabetes. 85 patients were classified on detection of diabetes as diabetes mellitus (DM) type 1, 228 as DM type 2. At the age under 30 years there were 10 subjects (group M), the remainder (304) formed group A. In this second part of the initial results the authors provide information on biochemical changes, prevalence of hypertension and vascular complications already during manifestation of DM...
March 2001: Vnitr̆ní Lékar̆ství
H H Schmidt, G Behrens, J Genschel, M Stoll, A Dejam, R Haas, M P Manns, R E Schmidt
There is accumulating evidence that human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) can induce hyperlipidaemia. To evaluate the frequency and type of hyperlipidaemia in PI-treated patients, 98 outpatients were prospectively analysed for their lipoprotein characteristics at the Medizinische Hochschule in Hannover, Germany. Fifty-seven percent of the patients studied presented with hyperlipidaemia. Both hypertrigylceridaemia (type IV and V hyperlipoproteinaemia, 33%) and hypercholesterolaemia (type IIa hyperlipoproteinaemia, 6%) were detectable...
1999: Antiviral Therapy
A H M Smelt
Familial dysbetalipoproteinaemia is an autosomal recessive, hereditary disorder of lipid metabolism caused by mutations in the apolipoprotein E gene. Homozygosity for apoE2 (1 in 170 persons) causes type III hyperlipoproteinaemia in less than 20% of the adult E2 homozygotes. The patients may present with typical skin lesions and have elevated plasma levels of cholesterol and triglycerides, mainly in very-low-density lipoprotein remnants and intermediate density lipoproteins. The disorder is associated with peripheral and coronary artery disease...
January 25, 2003: Nederlands Tijdschrift Voor Geneeskunde
Tadeusz Tacikowski, Jan Dzieniszewski, Grazyna Nowicka, Janusz Ciok
BACKGROUND: The purpose of our study was to compare lipid profile assessed by ultracentrifugation in various types of hyperlipoproteinemia (HLP) in correlation with obesity and hepatic steatosis diagnosed in the ultrasonic examination of the abdominal cavity. MATERIAL/METHODS: We studied 64 patients (38 women and 26 men with a mean age of 53.5 years) with various types of HLP, divided into two groups: 1) hypercholesterolemia, 2) mixed hyperlipoproteinemia. Lipid profile by ultracentrifugation was performed simultaneously with ultrasonic examination...
October 2002: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
F Holm, T Kovárník, M Aschermann, S Simek, A Linhart, J Humhal, R Skulec, V Reznícek
UNLABELLED: Direct percutaneous transluminal coronary angioplasty (d-PTCA) in patients with acute myocardial infarctions (AIM) has become an alternative of thrombolytic treatment. If the involved department has adequate experience the success rate of the procedure is high and the immediate and long-term results are better than those of thrombolysis. Moreover contrary to thrombolytic treatment successful percutaneous coronary intervention in AIM is more beneficial for patients also later than 6 hours after the development of infarction pain...
May 2002: Vnitr̆ní Lékar̆ství
M Shahmanesh, H Jaleel, Y DeSilva, J D Ross, M Caslake, R Cramb
OBJECTIVE: To determine the prevalence of type III hyperlipoproteinaemia in a cohort of HIV infected patients taking protease inhibitors and its correlation with the apolipoprotein-E2 isoform. DESIGN: Cross sectional study of 57 consecutive HIV infected subjects taking protease inhibitor therapy for a median of 12.5 (1-29) months, seen in an outpatient HIV clinic. Controls were 17 patients on non-nucleoside reverse transcriptor inhibitor therapy (NNRTI) for 9 (1-19) months and 50 antiviral naive patients...
August 2001: Sexually Transmitted Infections
H A Neil, G W Meijer, L S Roe
Plant sterols may be a useful additive therapy in the treatment of hypercholesterolaemic patients. The purpose of this study was to determine the effect of a fat spread enriched with vegetable oil sterols on plasma lipid, lipoprotein and apolipoprotein concentrations. A randomised double blind placebo-controlled crossover trial with two consecutive periods of 8 weeks was conducted. 30 patients with heterozygous familial hypercholesterolaemia treated concurrently with an HMG-CoA reductase inhibitor (statin) and 32 patients with type IIa primary hypercholesterolaemia with a total cholesterol concentration >6...
June 2001: Atherosclerosis
Y Ikeda, K Goji, A Takagi
We systematically investigated the molecular defects resulting in primary lipoprotein lipase (LPL) deficiency in a Japanese male infant (hereafter called 'the patient') with severe fasting hypertriglyceridaemia (type I hyperlipoproteinaemia). The primary LPL deficiency was diagnosed on the basis of the findings that no LPL activity was detected in post-heparin plasma (PHP) and that the immunoreactive LPL mass in PHP was less than 2% of the control level. The patient was a compound heterozygote for a novel missense mutation (G(568)GA-->AGA/Gly(105)-->Arg; G105R) in exon 3 and a missense mutation (GAC(867)-->GAG/Asp(204)-->Glu; D204E) in exon 5 of the LPL gene...
December 2000: Clinical Science (1979-)
B Vialettes, P Reynier, C Atlan-Gepner, N Mekki, L Lesluyes-Mazzochi, G Luc, D Lairon, Y Malthiery
This present case report describes two siblings with severe type V hyperlipoproteinaemia, diagnosed very early in life and due to the combination of the common apolipoprotein (Apo) E2 allele and rare mutant variant of ApoE, ApoE3 (Arg 136-->Ser). Phenotyping of ApoE falsely identified E2/E2 phenotype. The presence of mutated ApoE was suspected on an unusual restriction polymorphism of a Hha 1 restriction site and confirmed by sequence analysis of the cloned polymerase chain reaction fragment of exon 4 and familial segregation study...
June 2000: British Journal of Nutrition
A Grimaldi, A Heurtier
Epidemiologic studies indicate that hyperglycaemia is responsible for microangiopathy, but that its role in macroangiopathy is more controversial. The relative risk of coronary heart disease (CHD) is 2- to 3-fold greater for diabetic men and 3- to 5-fold greater for diabetic women. It is greater for lower limb arteriopathy (4- to 6-fold) and amputations (10- to 20-fold). Although relative risk is rather constant for different populations, absolute CHD risk depends on other risk factors and the rate of risk in the non-diabetic population...
June 1999: Diabetes & Metabolism
E Reiner, D Svedruzic, V Simeon-Rudolf, V Lipovac, M Gavella, V Mrzljak
The effect of heparin-induced extracorporal lipid precipitation (HELP) on the activities of paraoxonase (EC and arylesterase (EC was studied in serum of a patient with hyperlipoproteinaemia (A) and of a patient with non-insulin dependent diabetes mellitus and hyperlipoproteinaemia (B). The enzyme activities were measured spectrophotometrically (Tris-HCl buffer, pH 7.4, 37 degrees C) with paraoxon and phenylacetate as substrates of paraoxonase and arylesterase, respectively. Both patients underwent HELP applications once a week over a period of 7 weeks...
May 14, 1999: Chemico-biological Interactions
M Z Wojtukiewicz, D Lemancewicz, J Dziecioł, L Chrostek
The case of chylomicronaemia syndrome complicating clinical course of type-1 hyperlipoproteinaemia and insulin-dependent diabetes is described. The patient required hypoglycaemic and lipid-lowering therapy.
February 1999: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
G Turpin, E Bruckert
After defining the type of hyperlipoproteinaemia (the three main are IIa, IIb and IV), confirming its primary nature (i.e. after eliminating the various causes of secondary hyperlipoproteinaemia) and after defining the therapeutic objective (different according to the context of primary or secondary cardiovascular prevention), treatment must be prescribed. It always consists of diet, and very often a lipid-lowering drug. The remarkable results obtained with statins in studies of primary prevention, secondary prevention and regression of atherosclerosis does not mean that they can be prescribed blindly...
November 1998: Annales de Cardiologie et D'angéiologie
J Hrnciar, J Okapcová, J Lepej, D Gábor
Leptin levels in subjects with android obesity with the insulin resistance syndrome (syndrome X, 5H) are in general elevated, as compared with non-obese subjects and correlate with the BMI, with the percentage of body fat, WHR, IRI levels and sex (they are higher in women), as it is the case in the general population. In the elevated leptin level in syndrome 5H (association of hyperinsulinism, hyperglycaemia-NIDDM, hyperlipoproteinaemia with android obesity, arterial hypertension and hirsutism in females with the polycystic ovaries syndrome) participate in a significant way also elevated basal IRI and cortisol levels as well as an elevated postprandial IRI response during oGTT despite the fact that leptin and endothelin-1 levels do not rise significantly during oGTT despite hyperinsulinaemia...
February 1998: Vnitr̆ní Lékar̆ství
A Madej, B Okopień, J Kowalski, M Zieliński, J Wysocki, B Szyguła, Z Kalina, Z Herman
UNLABELLED: Tumor necrosis factor alpha (TNF alpha) secreted by activated macrophages stimulates proliferation and migration of vascular smooth muscle in atherogenesis. Up to now, the effect of fibrates on concentration of TNF-alpha has not been investigated. The aim of this study was to estimate TNF-alpha plasma concentration in healthy subjects before and after fenofibrate therapy in patients with hyperlipoproteinaemia IIb and to correlate their levels with plasma concentration of total cholesterol (TC), low density lipoproteins (LDL) and apolipoprotein B (ApoB)...
April 1998: Polskie Archiwum Medycyny Wewnętrznej
J Válek, Z Vlasáková
BACKGROUND: The metabolic syndrome is a common denominator of a number of risk factors which are associated with type 2 diabetes and serious cardiovascular complications. The symptoms develop on the background of insulin resistance and are associated with hyperinsulinism. They are not manifestations of ageing, but are developing probably on a predisposed background already in young age. METHODS AND RESULTS: In the families of 39 probands with symptoms of the metabolic syndrome (MS) there were 58 offspring, mean age...
September 1997: Vnitr̆ní Lékar̆ství
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