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Magnesium threonate AND Memory

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https://www.readbyqxmd.com/read/27178134/regulation-of-structural-and-functional-synapse-density-by-l-threonate-through-modulation-of-intraneuronal-magnesium-concentration
#1
Qifeng Sun, Jason G Weinger, Fei Mao, Guosong Liu
Oral administration of the combination of L-threonate (threonate) and magnesium (Mg(2+)) in the form of L-Threonic acid Magnesium salt (L-TAMS) can enhance learning and memory in young rats and prevent memory decline in aging rats and in Alzheimer's disease model mice. Recent results from a human clinical trial demonstrate the efficacy of L-TAMS in restoring global cognitive abilities of older adults. Previously, we reported that neuronal intracellular Mg(2+) serves as a critical signaling molecule for controlling synapse density, a key factor that determines cognitive ability...
September 2016: Neuropharmacology
https://www.readbyqxmd.com/read/26293690/by-suppressing-the-expression-of-anterior-pharynx-defective-1%C3%AE-and-1%C3%AE-and-inhibiting-the-aggregation-of-%C3%AE-amyloid-protein-magnesium-ions-inhibit-the-cognitive-decline-of-amyloid-precursor-protein-presenilin-1-transgenic-mice
#2
Xin Yu, Pei-Pei Guan, Jing-Wen Guo, Yue Wang, Long-Long Cao, Guo-Biao Xu, Konstantinos Konstantopoulos, Zhan-You Wang, Pu Wang
Alzheimer's disease (AD) is associated with a magnesium ion (Mg(2+)) deficit in the serum or brain. However, the mechanisms regulating the roles of Mg(2+) in the pathologic condition of AD remain unknown. We studied whether brain Mg(2+) can decrease β-amyloid (Aβ) deposition and ameliorate the cognitive decline in a model of AD, the APPswe/PS1DE9 transgenic (Tg) mouse. We used a recently developed compound, magnesium-L-threonate (MgT), for a treatment that resulted in enhanced clearance of Aβ in an anterior pharynx-defective (APH)-1α/-1β-dependent manner...
December 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/25213836/elevation-of-brain-magnesium-prevents-synaptic-loss-and-reverses-cognitive-deficits-in-alzheimer-s-disease-mouse-model
#3
Wei Li, Jia Yu, Yong Liu, Xiaojie Huang, Nashat Abumaria, Ying Zhu, Xian Huang, Wenxiang Xiong, Chi Ren, Xian-Guo Liu, Dehua Chui, Guosong Liu
BACKGROUND: Profound synapse loss is one of the major pathological hallmarks associated with Alzheimer's disease, which might underlie memory impairment. Our previous work demonstrates that magnesium ion is a critical factor in controlling synapse density/plasticity. Here, we tested whether elevation of brain magnesium, using a recently developed compound (magnesium-L-threonate, MgT), can ameliorate the AD-like pathologies and cognitive deficits in the APPswe/PS1dE9 mice, a transgenic mouse model of Alzheimer's disease...
2014: Molecular Brain
https://www.readbyqxmd.com/read/25152202/targeting-the-nmda-receptor-subunit-nr2b-for-treating-or-preventing-age-related-memory-decline
#4
REVIEW
Deheng Wang, Stephanie A Jacobs, Joe Z Tsien
INTRODUCTION: Age-related memory loss is believed to be a result of reduced synaptic plasticity, including changes in the NR2 subunit composition of the NMDA receptor. It is known that endogenous NR2B subunits decrease as the brain ages, whereas transgenic upregulation of NR2B enhances synaptic plasticity and learning and memory in several animal species. Accumulating evidence suggests that elevated brain magnesium levels, via dietary supplementation, can boost NR2B in the brain, consequently reversing memory deficits and enhancing cognitive abilities...
October 2014: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/24077207/magnesium-l-threonate-prevents-and-restores-memory-deficits-associated-with-neuropathic-pain-by-inhibition-of-tnf-%C3%AE
#5
Jun Wang, Yong Liu, Li-Jun Zhou, Ying Wu, Fei Li, Ka-Feng Shen, Rui-Ping Pang, Xu-Hong Wei, Yong-Yong Li, Xian-Guo Liu
BACKGROUND: Clinical studies have shown that about two-thirds of patients with chronic pain suffer from short-term memory (STM) deficits and an effective drug for treatment of the neurological disorder is lacking at present. OBJECTIVE: We tested whether chronic oral application of magnesium L-threonate (MgT), which has been shown to improve memory in normal and aging animals by elevating Mg2+ in the brain, could prevent or restore the STM deficits induced by spared nerve injury (SNI), an animal model of chronic neuropathic pain...
September 2013: Pain Physician
https://www.readbyqxmd.com/read/23764903/magnesium-supplement-enhances-spatial-context-pattern-separation-and-prevents-fear-overgeneralization
#6
RANDOMIZED CONTROLLED TRIAL
Nashat Abumaria, Lin Luo, Matae Ahn, Guosong Liu
Enhancement of pattern separation could be helpful in improving the quality of normal daily learning and in treating individuals with cognitive impairment and certain psychiatric disorders. Previously, we have shown that elevating brain magnesium, by a novel magnesium compound (magnesium-L-threonate; MgT), enhances extinction of fear memory without enhancing amygdala-dependent fear memory. Here, we investigated the effects of MgT treatment on contextual-fear memory and subsequent pattern separation. Sprague-Dawley male rats were treated with MgT for 4 weeks and memory was evaluated using a spatial-context fear conditioning task...
August 2013: Behavioural Pharmacology
https://www.readbyqxmd.com/read/23658180/elevation-of-brain-magnesium-prevents-and-reverses-cognitive-deficits-and-synaptic-loss-in-alzheimer-s-disease-mouse-model
#7
Wei Li, Jia Yu, Yong Liu, Xiaojie Huang, Nashat Abumaria, Ying Zhu, Xian Huang, Wenxiang Xiong, Chi Ren, Xian-Guo Liu, Dehua Chui, Guosong Liu
Profound synapse loss is one of the major pathological hallmarks associated with Alzheimer's disease (AD) and might underlie memory impairment. Our previous work demonstrated that the magnesium ion is a critical factor in controlling synapse density/plasticity. Here, we investigated whether elevation of brain magnesium by the use of a recently developed compound, magnesium-l-threonate (MgT), can ameliorate the AD-like pathologies and cognitive deficits in the APPswe/PS1dE9 mice, a transgenic (Tg) mouse model of AD...
May 8, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/23474371/chronic-dietary-magnesium-l-threonate-speeds-extinction-and-reduces-spontaneous-recovery-of-a-conditioned-taste-aversion
#8
G Andrew Mickley, Nita Hoxha, Joseph L Luchsinger, Morgan M Rogers, Nathanael R Wiles
Elevation of brain magnesium enhances synaptic plasticity and extinction of conditioned fear memories. This experiment examined the generalizability of this phenomenon by studying the effects of a novel magnesium compound, magnesium-L-threonate (MgT), on conditioned taste aversion (CTA) extinction and spontaneous recovery (SR). Adult male Sprague-Dawley rats were maintained on a 23-hour water deprivation cycle and acquired a CTA following the taste of a CS [0.3% saccharin+16 mg/ml MgT (SAC+MgT)] paired with a US [81 mg/kg (i...
May 2013: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/22016520/effects-of-elevation-of-brain-magnesium-on-fear-conditioning-fear-extinction-and-synaptic-plasticity-in-the-infralimbic-prefrontal-cortex-and-lateral-amygdala
#9
Nashat Abumaria, Bin Yin, Ling Zhang, Xiang-Yao Li, Tao Chen, Giannina Descalzi, Liangfang Zhao, Matae Ahn, Lin Luo, Chen Ran, Min Zhuo, Guosong Liu
Anxiety disorders, such as phobias and posttraumatic stress disorder, are among the most common mental disorders. Cognitive therapy helps in treating these disorders; however, many cases relapse or resist the therapy, which justifies the search for cognitive enhancers that might augment the efficacy of cognitive therapy. Studies suggest that enhancement of plasticity in certain brain regions such as the prefrontal cortex (PFC) and/or hippocampus might enhance the efficacy of cognitive therapy. We found that elevation of brain magnesium, by a novel magnesium compound [magnesium-l-threonate (MgT)], enhances synaptic plasticity in the hippocampus and learning and memory in rats...
October 19, 2011: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/20152124/enhancement-of-learning-and-memory-by-elevating-brain-magnesium
#10
COMPARATIVE STUDY
Inna Slutsky, Nashat Abumaria, Long-Jun Wu, Chao Huang, Ling Zhang, Bo Li, Xiang Zhao, Arvind Govindarajan, Ming-Gao Zhao, Min Zhuo, Susumu Tonegawa, Guosong Liu
Learning and memory are fundamental brain functions affected by dietary and environmental factors. Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement...
January 28, 2010: Neuron
https://www.readbyqxmd.com/read/20152120/kalzium-ist-nicht-alles
#11
REVIEW
Ashley I Bush
Elevation of cerebral Mg2+ with a novel orally delivered ionophore, magnesium threonate, enhances cognition in young and old rats over a 12-24 day treatment interval, as outlined in a paper by Slutsky et al. in this issue of Neuron. Despite both Mg2+ and Zn2+ blocking the NMDA receptor channel, sustained extracellular Mg2+ elevation mimics sustained synaptic Zn2+ concentrations by increasing hippocampal NR2B expression and bouton density.
January 28, 2010: Neuron
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