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https://www.readbyqxmd.com/read/29454755/evaluation-of-antidiabetic-potential-of-steroidal-alkaloid-of-sarcococca-saligna
#1
Naeem Ullah Jan, Amjad Ali, Bashir Ahmad, Naveed Iqbal, Achyut Adhikari, Inayat-Ur-Rehman, Abid Ali, Safdar Ali, Azra Jahan, Hamid Ali, Ijaz Ali, Anwar Ullah, Syed Ghulam Musharraf
The demand for natural medicines has increased because of their limited adverse effects. The aim of study is to explore the antidiabetic potential of isolated steroidal alkaloid from Sarcococca saligna in streptozotocin induced diabetic rats. To determine the antidiabetic activity of steroidal alkaloids, diabetes was induced in rats by injecting streptozotocin intraperitoneally at a dose of 40 mg/Kg. After a week of STZ injection the treatment were started and the 8th day was considered as the 1st day of treatment and up to four weeks the rats were treated with steroidal alkaloids...
February 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29446938/hypoglycemic-effect-of-pyrodextrins-with-different-molecular-weights-and-digestibilities-in-diet-induced-obese-mice
#2
Yan Cao, Xiaoli Chen, Ying Sun, Jialiang Shi, Xiaojuan Xu, Yong-Cheng Shi
Pyrodextrin shares some properties of resistant starch which is metabolically beneficial, and has potential applications as a functional food. In this study, we report that oral administration of pyrodextrin (50 mg/kg/d for 7 weeks) decreased the blood glucose (from 9.18±1.47 to 7.67±0.42 mmol/L), serum HbA1c, triglycerides, adipocyte size, and body weights (from 24.4±1.2 to 22.5±1.2 g) in high-fat diet-induced obese mice. The Western blotting analysis suggested that pyrodextrins decreased the intestinal SGLT-1 and GLUT-2 expression to ~70% and ~60% of the obese control to slow down glucose transportation from gut into blood, and improved the hepatic metabolism tentatively...
February 15, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29435776/effect-of-anagliptin-and-sitagliptin-on-low-density-lipoprotein-cholesterol-in-type-2-diabetic-patients-with-dyslipidemia-and-cardiovascular-risk-rationale-and-study-design-of-the-reason-trial
#3
Shinichiro Ueda, Michio Shimabukuro, Osamu Arasaki, Koichi Node, Takashi Nomiyama, Takeshi Morimoto
BACKGROUND: Reduction of low-density lipoprotein cholesterol (LDL-C) is important for patients with a high risk for atherosclerotic events, such as patients with diabetes and other risk factors. Anagliptin was reported to reduce LDL-C for 12 weeks in phase III trials regardless of the use of statins, but it is uncertain whether this effect is common to other dipeptidylpeptidase-4 (DPP-4) inhibitors. METHODS: A multicenter, randomized, open-label, parallel-group trial was conducted to confirm the superiority of anagliptin to sitagliptin in terms of the primary endpoint of reduction of LDL-C for 52 weeks in patients with type 2 diabetes and atherosclerotic vascular lesions, as well as the non-inferiority of anagliptin to sitagliptin in terms of change in hemoglobin A1c (HbA1c)...
February 12, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29430413/an-evaluation-of-the-impact-of-antidiabetic-medication-on-treatment-satisfaction-and-quality-of-life-in-patients-of-diabetes-mellitus
#4
Richa Chaturvedi, Chetna Desai, Prakruti Patel, Asha Shah, Ram K Dikshit
Aims: This study aims to measure the quality of life (QOL), treatment satisfaction, and tolerability of antidiabetic drugs in patients suffering from type 2 diabetes mellitus (DM). Methods: The prospective, observational study was conducted in consenting patients of type 2 DM attending the outpatient department of a tertiary care hospital in Western India. The QOL instrument for Indian diabetes (QOLID) patients questionnaire and the Diabetes Treatment Satisfaction Questionnaire were administered to all patients at baseline, 3 months, and 6 months of treatment...
January 2018: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/29427967/pleiotropic-effects-of-hypoglycemic-agents-implications-in-asthma-and-copd
#5
REVIEW
Paola Rogliani, Josuel Ora, Nicola Di Daniele, Davide Lauro
Diabetes mellitus (DM) is a complex multifactorial disease due to the interaction between environmental noxae and genetic predisposition. Furthermore, an increased association between DM, especially Type 2 diabetes mellitus (T2DM), and the onset of pulmonary function impairment with a bronchial hyperresponsiveness has been documented. DM is a risk factor for accelerated decline in FEV1 and the development of asthma and COPD. The increased blood glucose concentrations along with higher levels of oxidative stress and inflammation can influence the pulmonary function and, since hypoglycemic drugs can act on these different defects we can hypothesize their direct effect on obstructive pulmonary diseases...
February 7, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29412145/trends-in-diabetes-prevalence-among-korean-adults-based-on-korean-health-and-nutrition-examination-surveys-iii-vi
#6
Jae-Woo Lee, Hee-Taik Kang, Hyoung-Ji Lim, Byoungjin Park
AIMS: The purpose of this study was to investigate trends in diabetic prevalence over the past 11 years using Korea National Health and Nutrition Examination Survey (KNHANES) data. In addition, we aimed to examine trends in diagnosed and undiagnosed diabetes after stratification. METHODS: We used data from the KNHANES III (2005), IV (2007 - 2009), V (2010 - 2012), and VI (2013 - 2015). 46,157 participants were included in this study. Diabetes was defined as follows: 1) an answer of 'yes' to whether the participants had ever been diagnosed with diabetes by a physician, 2) fasting plasma glucose (FPG) ≥126 mg/dL, or 3) taking oral hypoglycemic agents or insulin...
February 2, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29391093/development-of-postoperative-diabetes-mellitus-in-patients-undergoing-distal-pancreatectomy-versus-whipple-procedure
#7
Adrienne Nguyen, Aram Demirjian, Maki Yamamoto, Kathryn Hollenbach, David K Imagawa
Because the islets of Langerhans are more prevalent in the body and tail of the pancreas, distal pancreatectomy (DP) is believed to increase the likelihood of developing new onset diabetes mellitus (NODM). To determine whether the development of postoperative diabetes was more prevalent in patients undergoing DP or Whipple procedure, 472 patients undergoing either a DP (n = 122) or Whipple (n = 350), regardless of underlying pathology, were analyzed at one month postoperatively. Insulin or oral hypoglycemic requirements were assessed and patients were stratified into preoperative diabetic status: NODM or preexisting diabetes...
October 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29390469/insulin-autoimmune-syndrome-in-a-pregnant-female-a-rare-case-report
#8
Xiang Xia Zeng, Yun Liang Tang, Kai Xiang Hu, Jiao Wang, Ling Yan Zhu, Jian Ying Liu, Jixiong Xu
RATIONALE: Insulin autoimmune syndrome (IAS) is an uncommon disorder characterized by hyperinsulinemic hypoglycemia related to insulin-binding autoantibodies. To the best of our knowledge, we report the first case of a pregnant female with IAS. PATIENT CONCERNS: The 26-year-old patient with Graves disease and 10 weeks pregnant developed IAS after approximately 6 months treatment with methimazole. The patient exhibited recurrent spontaneous hypoglycemia. DIAGNOSES: On evaluation, laboratory findings detected both high fasting insulin (>1000 mIU/L) and insulin autoantibodies...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29361845/the-impact-of-partnership-status-on-diabetes-control-and-self-management-behaviors
#9
Lindsay Haines, Natalie Coppa, Yael Harris, Juan P Wisnivesky, Jenny J Lin
According to the Centers for Disease Control and Prevention, diabetes affects 29.1 million people in the United States. Marriage has been suggested to have a protective effect on overall health outcomes, but few studies have evaluated the role of partnership status on patients with type 2 diabetes. This study aimed to assess this role of partnership status on diabetes control and self-management behaviors. Patients with type 2 diabetes taking at least one oral hypoglycemic agent were assessed over a 3-month period to measure hemoglobin A1c (HbA1c) changes and adherence to medication, exercise, diet, and glucose monitoring...
January 1, 2018: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29358046/clinical-course-of-a-cohort-with-type-2-diabetes-mellitus-after-endocrine-assessment-a-26-week-study
#10
Sandra Herranz-Antolín, Visitación Álvarez-de Frutos, Miguel Torralba
OBJECTIVE: To assess the degree of metabolic control and hypoglycemic treatments in a cohort of patients with type 2 diabetes mellitus (T2DM) after evaluation in an endocrinology clinic. MATERIAL AND METHODS: A prospective cohort study on 465 patients with T2DM who were not being monitored at an endocrinology clinic. Blood glucose control data and treatments received were recorded at an initial visit and after 26 weeks of follow-up. RESULTS: Baseline glycosylated hemoglobin (HbA1c) level was 8...
January 18, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29350773/effect-of-titanium-dioxide-nanoparticles-on-glucose-homeostasis-after-oral-administration
#11
Zhangjian Chen, Yun Wang, Xiang Wang, Lin Zhuo, Shi Chen, Shichuan Tang, Lin Zhao, Xianguo Luan, Guang Jia
As food additives, titanium dioxide nanoparticles (TiO2 NPs) have been widely used in various products that are usually simultaneously consumed with a high content of sugar, thus necessitating research on the effect of TiO2 NPs on glucose homeostasis. We conducted an animal study to explore the effect of orally administrated TiO2 NPs on glucose absorption and metabolism in rats at 0, 2, 10 and 50 mg kg-1 body weight day-1 for 30 and 90 days. The results showed that oral exposure to TiO2 NPs caused a slight and temporary hypoglycemic effect in rats at 30 days post-exposure but recovered at 90 days post-exposure...
January 19, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29335890/effectiveness-of-sodium-glucose-cotransporter-2-inhibitor-as-an-add-on-drug-to-glp-1-receptor-agonists-for-glycemic-control-of-a-patient-with-prader-willi-syndrome-a-case-report
#12
Yukio Horikawa, Mayumi Enya, Makie Komagata, Ken-Ichi Hashimoto, Masayo Kagami, Maki Fukami, Jun Takeda
INTRODUCTION: Diabetes patients with Prader-Willi syndrome (PWS) are obese because of hyperphagia; weight control by dietary modification and medicine is required for glycemic control. There are several recent reports showing the effectiveness of GLP-1 receptor agonists (GLP-1RAs) for diabetes treatment in PWS. CASE REPORT: A 36-year-old Japanese male patient was diagnosed with PWS at 10 years of age. At age 16 years, he was diagnosed with diabetes and began to take several kinds of oral hypoglycemic agents...
January 15, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29335533/fc-modified-exenatide-loaded-nanoparticles-for-oral-delivery-to-improve-hypoglycemic-effects-in-mice
#13
Yanan Shi, Xinfeng Sun, Liping Zhang, Kaoxiang Sun, Keke Li, Youxin Li, Qiang Zhang
To improve the oral efficiency of exenatide, we prepared polyethylene glycol-poly(lactic-co-glycolic acid) (PEG-PLGA) NPs modified with Fc (NPs-Fc) for exenatide oral delivery. Exenatide was encapsulated into the NPs by the w/o/w emulsion-solvent evaporation method. The particle size of the NPs-Fc was approximately 30 nm larger than that of the unmodified NPs with polydispersity indices in a narrow range (PDIs; PDI < 0.3) as detected by DLS, and the highest encapsulation efficiency of exenatide in the NPs was greater than 80%...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29333897/adherence-to-the-american-diabetes-association-retinal-screening-guidelines-for-population-with-diabetes-in-the-united-states
#14
JaeJin An, Fang Niu, Adam Turpcu, Yamina Rajput, T Craig Cheetham
PURPOSE: (1) To assess long-term adherence to American Diabetes Association guideline-recommended retinal screening among population with diabetes in the United States. (2) To determine factors associated with long-term adherence to routine eye screening exams. METHODS: A retrospective cohort study was conducted in adult patients with diabetes identified from January 2009 to December 2010. Patients were followed until disenrollment, death, or study end date (December 2013)...
January 15, 2018: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29327400/a-vitamin-b12-conjugate-of-exendin-4-improves-glucose-tolerance-without-associated-nausea-or-hypophagia-in-rodents
#15
Elizabeth G Mietlicki-Baase, Claudia G Liberini, Jayme L Workinger, Ron L Bonaccorso, Tito Borner, David J Reiner, Kieran Koch-Laskowski, Lauren E McGrath, Rinzin Lhamo, Lauren M Stein, Bart C De Jonghe, George G Holz, Christian L Roth, Robert P Doyle, Matthew R Hayes
AIMS: While pharmacological glucagon-like peptide-1 receptor (GLP-1R) agonists are FDA-approved for treating type 2 diabetes mellitus (T2DM) and obesity, a major side effect is nausea/malaise. We recently developed a conjugate of vitamin B12 bound to the GLP-1R agonist exendin-4 (Ex4), which displays enhanced proteolytic stability and retention of GLP-1R agonism. Here, we evaluate whether the conjugate (B12-Ex4) can improve glucose tolerance without producing anorexia and malaise. MATERIALS AND METHODS: We evaluated the effects of systemic B12-Ex4 and unconjugated Ex4 on food intake and body weight change, oral glucose tolerance, and nausea/malaise in male rats, and on intraperitoneal glucose tolerance in mice...
January 12, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29322007/co-administration-effects-of-aqueous-extract-of-turnip-leaf-and-metformin-in-diabetic-rats
#16
Moammadmehdi Hassanzadeh-Taheri, Mohammad Hassanpour-Fard, Mohammadreza Doostabadi, Hesam Moodi, Khadijeh Vazifeshenas-Darmiyan, Mehran Hosseini
Background: There is a variety of experimentally proven medicinal plants having antidiabetic properties but data on herb-drug interaction are very limited. Earlier studies indicated that aqueous extract of turnip leaf (AETL) has hypoglycemic potential in diabetic animals. The present study was conducted to evaluate co-administration effects of AETL and metformin, a commonly used antidiabetic drug, in diabetic rats. Methods: Metformin at the two different doses (50,100 mg/kg) and AETL at the dose of 400 mg/kg (separately or concurrent with metformin) were orally given to streptozotocin-induced diabetic rats for 4 weeks daily...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29302542/compliance-to-treatment-among-type-2-diabetics-receiving-care-at-peripheral-mobile-clinics-in-a-rural-block-of-vellore-district-southern-india
#17
Divya Elizabeth Muliyil, Kanagalakshmi Vellaiputhiyavan, Reginald Alex, Venkata Raghava Mohan
Background: Providing treatment to patients with diabetes mellitus in rural areas at a cost they can afford is a public health challenge. Aims: This study aims to measure the rate of compliance to oral hypoglycemic agents among patients with type 2 diabetes mellitus attending peripheral mobile clinics in rural South India. To study factors that impact glycemic control. Setting and Design: A cross-sectional study was done among patients attending peripheral mobile clinics in a rural block in Southern India...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29289540/a-randomized-controlled-study-comparing-a-dpp4-inhibitor-linagliptin-and-basal-insulin-glargine-in-patients-with-type-2-diabetes-in-long-term-care-and-skilled-nursing-facilities-linagliptin-ltc-trial
#18
Guillermo E Umpierrez, Saumeth Cardona, David Chachkhiani, Maya Fayfman, Sahebi Saiyed, Heqiong Wang, Priyathama Vellanki, J Sonya Haw, Darin E Olson, Francisco J Pasquel, Theodore M Johnson
OBJECTIVES: Safe and easily implemented treatment regimens are needed for the management of patients with type 2 diabetes mellitus (T2DM) in long-term care (LTC) and skilled nursing facilities. DESIGN: This 6-month open-label randomized controlled trial compared the efficacy and safety of a DPP4 inhibitor (linagliptin) and basal insulin (glargine) in LTC residents with T2DM. SETTINGS: Three LTC institutions affiliated with a community safety-net hospital, US Department of Veterans Affairs and Emory Healthcare System in Atlanta, Georgia...
December 27, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29278711/self-efficacy-self-care-and-glycemic-control-in-saudi-arabian-patients-with-type-2-diabetes-mellitus-a-cross-sectional-survey
#19
Ahmad M J Saad, Zeina M H Younes, Hafez Ahmed, Jason A Brown, Rafat M Al Owesie, Ahmed A K Hassoun
AIMS: To determine the prevalence of diabetes self-care activities among type 2 diabetes patients and examine the association between socio-demographic and clinical parameters, diabetes self-care activities, and glycemic control among type 2 diabetes patients. METHODS: A cross sectional study was conducted among patients with diabetes (n=123) at the Sultan Bin Abdulaziz Humanitarian City (SBAHC). A regression model was used to examine the variables that predicted glycemic control...
December 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29258218/in-vitro-investigation-of-the-interaction-of-tolbutamide-and-losartan-with-human-serum-albumin-in-hyperglycemia-states
#20
Agnieszka Szkudlarek, Danuta Pentak, Anna Ploch, Jadwiga Pożycka, Małgorzata Maciążek-Jurczyk
Serum albumin is exposed to numerous structural modifications which affect its stability and activity. Glycation is one of the processes leading to the loss of the original properties of the albumin and physiological function disorder. In terms of long lasting states of the hyperglycemia, Advanced Glycation End-products (AGEs) are formed. AGEs are responsible for cellular and tissue structure damage that cause the appearance of a number of health consequences and premature aging. The aim of the present study was to analyze the conformational changes of serum albumin by glycation-"fructation"-using multiple spectroscopic techniques, such as absorption (UV-Vis), fluorescence (SFM), circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy and evaluate of possible alteration of binding and competition between tolbutamide (TB, a first-generation sulfonylurea oral hypoglycemic drug) and losartan (LOS, an angiotensin II receptor (AT₁) blocker used in hypertension (1st line with a coexisting diabetes)) in binding to non-glycated (HSA) and glycated (gHSAFRC) human serum albumin in high-affinity binding sites...
December 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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