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oral hypoglycemics

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https://www.readbyqxmd.com/read/29235180/the-effects-of-hypoglycemia-and-weight-loss-of-total-lignans-from-fructus-arctii-in-kkay-mice-and-its-mechanisms-of-the-activity
#1
Yingying Gao, Chenchen Gu, Kai Wang, Haiying Wang, Kefeng Ruan, Zhaohui Xu, Yi Feng
Fructus Arctii (great burdock achene) is the dried ripe fruit of Arctium lappa L. (family Asteraceae) and is included in the Chinese pharmacopoeia. It has been reported that the clinical use of Fructus Arctii resulted in a satisfactory hypoglycemic effect in diabetic patients. This study aimed to investigate antidiabetic activity and mechanism of total lignans from Fructus Arctii (TLFA) in KKAy mice, a spontaneous Type 2 diabetic rodent model that exhibits marked obesity. In this study, KKAy mice were gavaged once daily with solvents (0...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29226733/enteric-coated-insulin-microparticles-delivered-by-lipopeptides-of-iturin-and-surfactin
#2
Xiaoying Xing, Xiuyun Zhao, Jia Ding, Dongming Liu, Gaofu Qi
Surfactin, a lipopeptide produced by Bacillus species, has been used for the oral delivery of insulin. In this study, another lipopeptide of iturin was tested for its ability to orally delivery insulin alone or plus surfactin. Iturin could form co-precipitate with insulin at acidic pH values. After treatment by ultrasonification, the structure of coprecipitate was destroyed that led to a significant decrease in hypoglycemic effect after oral administration. Iturin weakly binds to (Kd = 257 μM) and induce insulin structure more compact that is favorable for insulin uptake by the intestine...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29220052/hypoglycemic-and-hypolipidemic-effects-of-anthocyanins-extract-from-black-soybean-seed-coat-in-high-fat-diet-and-streptozotocin-induced-diabetic-mice
#3
Zhongqin Chen, Cong Wang, Yuxiang Pan, Xudong Gao, Haixia Chen
Black soybean seed coat extract (BSSCE) is a rich source of anthocyanins with multiple health effects. This study was aimed at investigating the composition and hypoglycemic and hypolipidemic effects of BSSCE in vitro and in a high-fat diet and streptozotocin (STZ)-induced diabetic mice. The anthocyanins of BSSCE were identified as cyanidin-3-O-glucoside, delphinidin-3-O-glucoside, and peonidin-3-O-glucoside by HPLC-MS. Results demonstrated that BSSCE exhibited strong inhibitory activities for α-amylase, potent inhibition activity against lipid accumulation in HepG2 cells and protection effect on H2O2-induced oxidative stress-damaged HepG2 cells...
December 8, 2017: Food & Function
https://www.readbyqxmd.com/read/29216790/dual-therapy-appears-superior-to-monotherapy-for-low-income-individuals-with-newly-diagnosed-type-2-diabetes
#4
Elizabeth M Vaughan, Craig A Johnston, David J Hyman, Daphne C Hernandez, Vagish Hemmige, John P Foreyt
BACKGROUND: There are variable recommendations regarding initiating monotherapy or dual therapy in patients with newly diagnosed type 2 diabetes (T2D). Clear initial strategies are of particular importance in underserved settings where access to care and financial burdens are significant barriers. OBJECTIVES: To provide descriptive data of metabolic outcomes to therapy regimens for low-income individuals with newly diagnosed T2D placed on oral hypoglycemic agents (OAs)...
December 1, 2017: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/29205907/prevalence-treatment-patterns-and-control-rates-of-metabolic-syndrome-in-a-chinese-diabetic-population-ccmr-3b-study
#5
Yali Jing, Ting Hong, Yan Bi, Dayi Hu, Guojuan Chen, Jihu Li, Ye Zhang, Ruya Zhang, Linong Ji, Dalong Zhu
AIMS: To investigate the prevalence and risk factors of Metabolic Syndrome (MetS) in Chinese type 2 diabetes mellitus (T2DM) patients and assess the effect of MetS on the treatment patterns and 3B (blood glucose, blood pressure, blood lipids) goal achievements. MATERIALS AND METHODS: Data from 25,454 T2DM patients including demographic data, anthropometric measurements, treatment patterns and blood glucose and lipid profiles were retrospectively analyzed. RESULTS: Using modified ATP III MetS criteria, the prevalence of MetS was 57...
December 4, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29205704/hypoglycemia-in-sulfonylurea-treated-kcnj11-neonatal-diabetes-mild-moderate-symptomatic-episodes-occur-infrequently-but-none-involving-unconsciousness-or-seizures
#6
Monica S Lanning, David Carmody, Łukasz Szczerbiński, Lisa R Letourneau, Rochelle N Naylor, Siri Atma W Greeley
BACKGROUND: Neonatal diabetes mellitus (NDM) caused by mutations in KCNJ11 can be successfully treated with high dose oral sulfonylureas; however, little data is available on the risk of hypoglycemia. OBJECTIVE: To determine the frequency, severity, and clinical significance of hypoglycemia in KCNJ11-related NDM. METHODS: Utilizing the University of Chicago Monogenic Diabetes Registry, parents completed an online questionnaire addressing hypoglycemia...
December 5, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29200880/estimating-the-risk-of-severe-hypoglycemic-event-related-to-glucose-lowering-treatment-among-italian-patients-with-diabetes-the-hypothesis-database
#7
Silvio Mazzi, Roberto Ravasio, Gabriele Forlani, Giacomo Veronese, Andrea Fabbri, Giulio Marchesini
The primary objective of this study was to estimate 1) the annual risk of undergoing a severe hypoglycemic event in Italian patients with diabetes and 2) the risk of hospitalization following such event. From the HYPOTHESIS database, powered by 46 emergency departments covering a 12-million-odd population, data were extracted of 1,922 hypoglycemic events occurring in patients with diabetes in 2011. The mean age was 71.5 (standard deviation 16.8) years, 50.1% were men, and blood glucose at the time of the event was 44...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29200879/cost-consequence-analysis-of-sitagliptin-versus-sulfonylureas-as-add-on-therapy-for-the-treatment-of-diabetic-patients-in-italy
#8
Valentina Lorenzoni, Fabio Baccetti, Stefano Genovese, Enrico Torre, Giuseppe Turchetti
Objective: Diabetes mellitus is a chronic disease related to a significant impact in both epidemiologic and economic terms. In Italy, around 3.6 million people are affected by diabetes and this number is expected to increase significantly in the next few years. As recommended by current national and international guidelines, metformin (Met) is prescribed as first-line pharmacological treatment, and many pharmacological alternatives are available for patients uncontrolled with Met monotherapy...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29196152/nanotechnology-based-approaches-for-anti-diabetic-drugs-delivery
#9
REVIEW
Prashant Kesharwani, Bapi Gorain, Siew Yeng Low, Siew Ann Tan, Emily Chai Siaw Ling, Yin Khai Lim, Chuan Ming Chin, Pei Yee Lee, Chun Mey Lee, Chun Haw Ooi, Hira Choudhury, Manisha Pandey
Nanotechnology science has been diverged its application in several fields with the advantages to operate with nanometric range of objects. Emerging field of nanotechnology has been also being approached and applied in medical biology for improved efficacy and safety. Increased success in therapeutic field has focused several approaches in the treatment of the common metabolic disorder, diabetes. The development of nanocarriers for improved delivery of different oral hypoglycemic agents compared to conventional therapies includes nanoparticles (NPs), liposomes, dendrimer, niosomes and micelles, which produces great control over the increased blood glucose level and thus becoming an eye catching and most promising technology now-a-days...
November 28, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29196134/a-review-of-the-traditional-and-modern-uses-of-salvadora-persica-l-miswak-toothbrush-tree-of-prophet-muhammad
#10
REVIEW
Muhammad Zakariyyah Aumeeruddy, Gokhan Zengin, Mohamad Fawzi Mahomoodally
ETHNOPHARMACOLOGICAL RELEVANCE: Salvadora persica L., also known as Arak (in Arabic) and Peelu (in Urdu), is the most common traditional source of tooth or chewing stick (miswak) highly recommended by Prophet Muhammad. To date, extensive studies have probed primarily into the validation of its traditional uses in oral care. Nonetheless, there is still a dearth of updated compilation and critical analysis of other potential ethnopharmacological properties of S. persica. This review therefore aims to provide an up-to-date detailed structured description of the traditional uses of S...
November 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29191422/resistant-starch-produces-antidiabetic-effects-by-enhancing-glucose-metabolism-and-ameliorating-pancreatic-dysfunction-in-type-2-diabetic-rats
#11
Hui Sun, Xiaohan Ma, Shiqi Zhang, Dan Zhao, Xiong Liu
The aim of the study was to evaluate the hypoglycemic effect of low, medium, and high doses of resistant starch type 2(RS2;100, 150, and 200g/kg) for 28days and explore its potential mechanism of this effect in type 2 diabetic rats treated with high-glucose-fat diet and low-dose streptozotocin(STZ). RS2 treatment induced better regulation of lipid in plasma and liver, fructosamine, oral glucose tolerance test, insulin, glucose metabolism and pancreatic damage in diabetic rats. The best hypoglycemic activity was observed after the medium-dose RS2 treatment...
November 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29175551/retrograded-starch-pectin-coated-gellan-gum-microparticles-for-oral-administration-of-insulin-a-technological-platform-for-protection-against-enzymatic-degradation-and-improvement-of-intestinal-permeability
#12
Andréia B Meneguin, Eric Beyssac, Ghislain Garrait, Hassana Hsein, Beatriz S F Cury
Gellan gum microparticles coated with colon-specific films based on retrograded starch and pectin was developed for enhancing the oral release of insulin (INS). The system developed promoted an impressive protection of INS (80%) after 120 min of incubation with trypsin and alpha-chymotrypsin, while only 3% of free INS remained intact after the same time, possibility due to the calcium chelating activity of the polymers in inhibiting the proteolytic activity. In vitro INS release in media simulating the gastrointestinal portions revealed a pH-dependent behavior, as well as the significance of the coating in lowering the release rates in relation to their counterparts...
November 23, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29168921/bauhinia-forficata-in-the-treatment-of-diabetes-mellitus-a-patent-review
#13
Bárbara Verônica Cardoso de Souza, Regilda Saraiva Dos Reis Moreira Araújo, Oskar Almeida Silva, Lucas Costa Faustino, Maria Fabrícia Beserra Gonçalves, Mirian Lima Dos Santos, Grasielly Rocha Souza, Lindalva Moura Rocha, Mônica Larissa Sousa Cardoso, Lívio César Cunha Nunes
Diabetes Mellitus has been considered an epidemic by the World Health Organization, with a high risk of morbidity and mortality. The treatment of this pathology consists in glycemic control, which can be done by oral hypoglycemic agents, insulin therapy, dietary guidance, regular physical activity, and psychosocial support. In addition, other adjuvant treatments are employed, such as phytotherapic, and one of the most used plants is Bauhinia forficata. Areas covered: in the current review, patents using Bauhinia forficata for the Diabetes Mellitus treatment have been analyzed...
November 23, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29168157/perioperative-implications-of-sodium-glucose-cotransporter-2-inhibitors-a-case-series-of-euglycemic-diabetic-ketoacidosis-in-three-patients-after-cardiac-surgery
#14
Aaron Lau, Simon Bruce, Erica Wang, Ron Ree, Kevin Rondi, Anthony Chau
PURPOSE: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) comprise the newest class of oral hypoglycemic agents approved for treating type II diabetes mellitus (DM-II). Their use, however, has been associated with the rare development of euglycemic diabetic ketoacidosis (euDKA). We present three cases of euDKA that occurred following elective coronary artery bypass grafting surgery. The role of the anesthesiologist in the prevention, diagnosis, and management of this complication is also discussed...
November 22, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29168127/bioavailability-of-orally-administered-des-aspartate-angiotensin-i-in-human-subjects
#15
Kok-Onn Lee, Edmund Feng Tian, Martin Hui Cai, Hong Wang, Yiong-Huak Chan, Meng-Kwoon Sim
In an earlier single-dose escalation study to evaluate the safety and pharmacokinetics of orally administered des-aspartate-angiotensin I (DAA-I) in healthy subjects, the plasma level of DAA-I could not be determined because DAA-I is rapidly degraded in the circulation. The present study investigated the oral bioavailability of DAA-I by measuring the prostaglandin E2 metabolite (PGEM) in the plasma samples of the same trial. PGEM is a stable derivative of PGE2, which has been shown to be a biomarker of DAA-I...
November 22, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/29165101/therapeutic-potentials-and-cytochrome-p450-mediated-interactions-involving-herbal-products-indicated-for-diabetes-mellitus
#16
Cyprian Ogbonna Onyeji, Sharon I Igbinoba, Gbola Olayiwola
There has been an increase in the use of herbal products to complement conventional drugs in the treatment of various diseases especially in developing countries. This may be attributable to the relatively cost-effectiveness and ease of accessibility of these products as well as the perception of their safety profiles. However, there are numerous literature reports on herbs altering the pharmacokinetics and pharmacodynamics of other co-administered drugs thereby modulating the therapeutic outcomes. The prevalence of diabetes is on a steady increase worldwide and it is now identified as one of the main threats to human health...
November 20, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/29163935/the-cost-of-diabetes-in-latin-america-and-the-caribbean-in-2015-evidence-for-decision-and-policy-makers
#17
Alberto Barcelo, Armando Arredondo, Amparo Gordillo-Tobar, Johanna Segovia, Anthony Qiang
BACKGROUND: The financial implications of the increase in the prevalence of diabetes in middle-income countries represents one of the main challenges to health system financing and to the society as a whole. The objective of this study was to estimate the economic cost of diabetes in Latin America and the Caribbean (LAC) in 2015. METHODS: The study used a prevalence-based approach to estimate the direct and indirect costs related to diabetes in 29 LAC countries in 2015...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29163734/risk-of-obstructive-sleep-apnea-assessment-among-patients-with-type-2-diabetes-in-taif-saudi-arabia
#18
Reem Mohammed Noor Kalakattawi, Afnan Mohammed Noor Kalakattawi, Faisal Adel Alsuqati, Sultanh Abdullah Alzhrani, Abdulmohsen Hamad Alhamyani, Abdulaziz Hamad Alhamyani, Abrar Abdullah Al-Ghamdi, Ibtesam Mohammad Alosaimi, Salwa Ibrahim Abbas, Lojain AbdulAziz Al-Shehri, Abdulrahman Ahmad Alzahrani
Background: Obstructive sleep apnea (OSA) is a common condition in middle-aged persons worldwide. The major factor risk of this disease is obesity. Methods: A cross-sectional study was performed at King Abdul-Aziz Specialist Hospital. A STOP-BANG questionnaire formed of eight questions was used to assess the risk of OSA among type 2 diabetic patients. The scoring scale is categorized into three groups: low (0 - 2), intermediate (3 - 4) and high (5 - 8), respectively...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29152763/diabetes-metabolic-comorbidities-and-risk-of-hepatocellular-carcinoma-results-from-two-prospective-cohort-studies
#19
Tracey G Simon, Lindsay Y King, Dawn Q Chong, Long Nguyen, Yanan Ma, Trang VoPham, Edward L Giovannucci, Charles S Fuchs, Jeffrey A Meyerhardt, Kathleen E Corey, Hamed Khalili, Raymond T Chung, Xuehong Zhang, Andrew T Chan
BACKGROUND: Type 2 diabetes (T2D) is a risk factor for hepatocellular carcinoma (HCC). However, it is unknown whether T2D duration or additional metabolic comorbidities further contribute to HCC risk. METHODS: From the Nurses' Health Study (NHS), 120,826 women were enrolled in 1980, and from the Health Professionals Follow-up Study (HPFS), 50,284 men were enrolled in 1986, and followed through 2012. Physician-diagnosed T2D was ascertained at baseline and updated biennially...
November 20, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29151531/repeated-hypoglycemic-episodes-with-postprandial-hyperinsulinemia-after-the-recovery-from-acute-weight-loss-revealed-by-continuous-glucose-monitoring-and-the-oral-glucose-tolerance-test
#20
Seizaburo Masuda, Masanori Murakami, Ryotaro Bouchi, Isao Minami, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
We herein report a case of a 20-year-old woman who experienced hypoglycemia in parallel with acute weight loss confirmed by continuous glucose motoring (CGM). When she recovered from the acute weight loss, CGM revealed nocturnal and postprandial hypoglycemia. Six months were required to resolve the hypoglycemia and hyperinsulinemia after the recovery of her weight. Our case suggests that the adaption of insulin secretion to the rapid loss of weight and to the recovery of weight may require a long period of time, leading to the excessive secretion of insulin relative to the glucose level and repeated hypoglycemic episodes with postprandial hyperinsulinemia...
November 20, 2017: Internal Medicine
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