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oral hypoglycemics

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https://www.readbyqxmd.com/read/29677194/combined-intervention-of-swimming-plus-metformin-ameliorates-the-insulin-resistance-and-impaired-lipid-metabolism-in-murine-gestational-diabetes-mellitus
#1
Liping Huang, Pingping Yue, Xuefei Wu, Ting Yu, Yang Wang, Ji Zhou, Derun Kong, Keyang Chen
Gestational diabetes mellitus (GDM) has short- and long- term influence on pregnant women and fetus. Swimming, as an aerobic exercise, can effectively improve the blood glucose level in GDM, but the effect of mild swimming alone was not very substantial. Metformin, as an oral antidiabetic drug, has obvious hypoglycemic effect, and is economic also, but the long-term effect on pregnant women and fetus has not been completely clear. We hypothesize that combined intervention of mild swimming and low dose of metformin, may effectively reduce blood glucose, improve the pregnancy outcomes in GDM dams, but simultaneously avoiding the adverse effects caused by overdose of drug and impotence of mild swimming...
2018: PloS One
https://www.readbyqxmd.com/read/29674278/cassia-grandis-fruit-extract-reduces-the-blood-glucose-level-in-alloxan-induced-diabetic-rats
#2
Ariadna Lafourcade Prada, Jesús Rafael Rodríguez Amado, Hady Keita, Edgar Puente Zapata, Helison Carvalho, Emersom Silva Lima, Tatiane Pereira de Sousa, José Carlos Tavares Carvalho
INTRODUCTION: Cassia grandis Lf fruits are ethnobotanically used for digestive disorders, anemia, and for reducing blood glucose. However, there are no studies about the antidiabetic activity nor the oral toxicity of the plant fruit-extracts. This paper aims to evaluate the hypoglycemic effect of C. grandis fruits extract in vivo, and assess the acute oral toxicity, and sub-acute oral toxicity. The antioxidant activity and the α-glycosidase inhibitor effect were also evaluated. METHODS: The extract was obtained by maceration of the fruit pulp with 70% hydroalcoholic solution (1:2, m:v)...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29670663/the-effect-of-sanggua-drink-extract-on-insulin-resistance-through-the-pi3k-akt-signaling-pathway
#3
Yu Cai, Ying Wang, Fei Zhi, Qi-Chang Xing, Yun-Zhong Chen
Treating type 2 diabetes mellitus (T2DM) using thiazolidinediones and biguanides can present several challenges for patients. Sanggua Drink (SGD) is a commonly used agent in traditional Chinese medicine, and it consists of Folium Mori , Fructus Momordicae Charantiae , Radix Puerariae Lobatae , and Rhizoma Dioscorea . The hypoglycemic effects and mechanisms of SGD extracts on insulin resistance in diabetic rats were investigated. SGD (1.24 g/kg orally) was verified in T2DM rats induced by a high-fat diet and streptozotocin...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29670384/screening-and-management-of-gestational-diabetes-in-mexico-results-from-a-survey-of-multilocation-multi-health-care-institution-practitioners
#4
Livia Dainelli, Alberto Prieto-Patron, Irma Silva-Zolezzi, Sandra G Sosa-Rubi, Salvador Espino Y Sosa, Enrique Reyes-Muñoz, Ruy Lopez-Ridaura, Patrick Detzel
Purpose: To identify the most common practices implemented for the screening and treatment of gestational diabetes mellitus (GDM) and to estimate the GDM clinician-reported proportion as a proxy of the incidence in Mexico. Materials and methods: Three hundred fifty-seven physicians in four major cities were asked about their practices regarding GDM screening, treatment, clinical exams, and health care staff involved in case of GDM diagnosis, as well as the percentage of women with GDM they care for...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29670330/the-efficacy-and-safety-of-ginkgo-biloba-extract-as-an-adjuvant-in-type-2-diabetes-mellitus-patients-ineffectively-managed-with-metformin-a-double-blind-randomized-placebo-controlled-trial
#5
Tavga Ahmed Aziz, Saad Abdulrahman Hussain, Taha Othman Mahwi, Zheen Aorahman Ahmed, Heshu Sulaiman Rahman, Abdullah Rasedee
Background and aim: Type 2 diabetes mellitus (T2DM) is one of the major diseases confronting the health care systems. In diabetes mellitus (DM), combined use of oral hypoglycemic medications has been shown to be more effective than metformin (Met) alone in glycemic control. This study determined the effects of Ginkgo biloba (GKB) extract as an adjuvant to Met in patients with uncontrolled T2DM. Subjects and methods: Sixty T2DM patients were recruited in a randomized, placebo-controlled, double-blinded, and multicenter trial...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29664632/ph-and-amylase-responsive-carboxymethyl-starch-poly-2-isobutyl-acrylic-acid-hybrid-microgels-as-effective-enteric-carriers-for-oral-insulin-delivery
#6
Liang Liu, Ying Zhang, Shuangjiang Yu, Zhen Zhang, Chaoliang He, Xuesi Chen
Oral delivery of insulin has the potential to revolutionize diabetes care since it is regarded as a non-invasive therapeutic approach without the side effects caused by frequent subcutaneous injection. However, the insulin delivery efficiency through oral route was still limited, likely due to the chemical, enzymatic and absorption barriers. In this study, a novel type of pH- and amylase-responsive microgels as an insulin drug carrier for oral administration was developed to improve the drug delivery efficiency...
April 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29657678/safety-of-sodium-glucose-cotransporter-2-inhibitors-sglt2-i-during-the-month-of-ramadan-in-muslim-patients-with-type-2-diabetes
#7
Alaaeldin Bashier, Azza Abdulaziz Khalifa, Elamin Ibrahim Abdelgadir, Maryam Ahmad Al Saeed, Amina Adil Al Qaysi, Murad Burhan Ali Bayati, Budoor Alemadi, Fawzi Bachet, Fatheya Alawadi, Mohammed Hassanein
Objectives: Sodium-glucose cotransporter 2 inhibitors (SGLT2-I) are a new class of antidiabetic drugs that might increase the risk of dehydration and hypoglycemia, particularly during the month of Ramadan in which Muslims abstain from eating and drinking for 14-16 hours daily. We aimed to provide real-life evidence about the safety of SGLT2-I during Ramadan. Methods: All patients over the age of 18 years on SGLT2-I before Ramadan 2016 who would be fasting during Ramadan were included...
March 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29651878/in-vivo-hypoglycemic-effect-of-kigelia-africana-lam-studies-with-alloxan-induced-diabetic-mice
#8
Stephen M Njogu, Wycliffe M Arika, Alex K Machocho, Joseph J N Ngeranwa, Eliud N M Njagi
The claims by the traditional herbal medicine practitioners that Kigelia africana has bioactivity against several diseases, including diabetes mellitus, were investigated in this study. Type I diabetes mellitus was induced in mice by intraperitoneal administration of alloxan monohydrate followed by treatment with the therapeutic doses of the aqueous and ethyl acetate leaf extract of K africana to the experimentally diabetic mice. The treatment effects were compared with the normal control, diabetic control, and diabetic control rats treated with a standard antidiabetic drugs (insulin administered intraperitoneally at 1 IU/kg body weight in 0...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29649536/characterization-of-momordica-charantia-l-polysaccharide-and-its-protective-effect-on-pancreatic-cells-injury-in-stz-induced-diabetic-mice
#9
Cong Zhang, Hongman Chen, Weiqi Bai
A polysaccharide with a molecular weight of 13,029 Da was isolated from Momordica charantia (MCP) fruit and purified by ion-exchange and size-exclusion chromatography. The isolated polysaccharide MCPIIa contained L-Rha, D-GalA, D-Gal, D-Xyl, L-Ara in a molar ratio of 12:3.05:19.89:5.95:56. IR spectrum and NMR studies indicated that the MCPIIa sugar units were linked, via β-glycosidic bonds, to a large number of arabinofuranose, glucuronic acid, and xylopyranosyl residues. In addition, the hypoglycemic effect of MCPIIa was investigated in streptozotocin (STZ)-induced diabetic mice...
April 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29626586/outcomes-of-integrated-management-versus-specialized-care-for-patients-with-type-2-diabetes-an-observational-study
#10
I Sabione, F Cavalot, P Paccotti, P Massucco, F D Vigna-Taglianti
AIMS: To compare type 2 diabetes (T2D) patients included in a Diabetes Integrated Management (DIM) program with those followed in Diabetes Specialized Care (DSC), investigating differences in general characteristics, changes in clinical outcomes, and factors related with the inclusion in the DIM program. METHODS: T2D patients living in the ASLTO3 district and included into the DIM program, a shared disease management between general practitioners and diabetes specialists, from 2008 to 2014 were compared with T2D patients living in the same district and in charge of the local DSC...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29617268/antidiabetic-and-renoprotective-effect-of-anogeissus-acuminata-leaf-extract-on-experimentally-induced-diabetic-nephropathy
#11
Archana M Navale, Archana Paranjape
BACKGROUND: Diabetic nephropathy is the leading cause of end-stage renal disease. Hyperglycemia, oxidative stress, and inflammation are some of the mechanisms involved in renal damage. Anogeissus acuminata (AA) is used in India as an antidiabetic agent and has potent antioxidant activity. However, it has never been evaluated for its effect on diabetic nephropathy. Hence, in the present study we aimed to evaluate its effect on streptozotocin-induced diabetes mellitus and its renal complications...
April 4, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29597206/curcumin-alleviates-diabetic-retinopathy-in-experimental-diabetic-rats
#12
Fang Yang, Jinqiang Yu, Feng Ke, Mei Lan, Dekun Li, Ke Tan, Jiaojiao Ling, Ying Wang, Kaili Wu, Dai Li
PURPOSE: To investigate the potential protective effects of curcumin on the retina in diabetic rats. METHODS: An experimental diabetic rat model was induced by a low dose of streptozotocin combined with a high-energy diet. Rats which had blood glucose levels ≥11.6 mmol/L were used as diabetic rats. The diabetic rats were randomly divided into 3 groups: diabetic rats with no treatment (DM), diabetic rats treated with 100 mg/kg curcumin (DM + Cur 100 mg/kg), and diabetic rats treated with 200 mg/kg curcumin (DM + Cur 200 mg/kg)...
March 29, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29597167/engineering-a-novel-protease-based-exendin-4-derivative-for-type-2-antidiabetic-therapeutics
#13
Xia Zhong, Shaomin Yang, Tianxiang Liu, Shundong Ji, Jinrui Hu, Hongjian Li
To develop an effective long-acting antidiabetic agent, we designed a novel Exendin-4 derivative (termed LEx4) containing an albumin-binding domain (ABD), a protease-cleavable linker and a native Exendin-4. Here, we present the LEx4 with balanced glucoregulatory activity and prolonged in vivo activity. As a first step, the LEx4 with purity more than 99% was prepared. Microscale thermophoresis (MST) results demonstrated that LEx4 associates with rat and monkey serum albumin with high-affinity (Ka  = 1.26 × 106  M-1 and 1...
March 21, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29590421/incidence-of-hypoglycemia-after-gastric-bypass-versus-sleeve-gastrectomy-a-randomized-trial
#14
Esmeralda Capristo, Simona Panunzi, Andrea De Gaetano, Valerio Spuntarelli, Rocco Bellantone, Piero Giustacchini, Andreas L Birkenfeld, Stephanie Amiel, Stefan R Bornstein, Marco Raffaelli, Geltrude Mingrone
Contest-&-Objective: We compared the incidence of hypoglycemia after Roux-en-Y-Gastric-Bypass (RYGB) versus Sleeve Gastrectomy (SG). Design-Setting-and- Main Outcome Measure: Randomized, open-label trial conducted at the outpatient obesity-clinic in a university-hospital in Rome, Italy. The primary aim was the incidence of reactive hypoglycemia (<3.1 mmol/l after 75g-oral-glucose-load) at 1 year after surgery (intention-to-treat-analysis, carried-forward for missing data)...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29581705/hypoglycemic-coma-in-a-hemodialysis-patient-receiving-blood-glucose-lowering-therapy-with-the-single-agent-teneligliptin
#15
Takumi Minezumi, Shin-Ichi Takeda, Yusuke Igarashi, Kentaro Sato, Yoshiaki Murakami, Daisuke Nagata
Blood glucose management in patients undergoing dialysis is clinically challenging. In this population, most conventional oral hypoglycemic agents are contraindicated, especially from the perspective of pharmacokinetics. Dipeptidyl peptidase-4 inhibitors exert unique pharmacologic actions via glucose-dependent mechanism and have an excellent tolerability profile with a very low risk of hypoglycemia. Furthermore, the literature reports that some dipeptidyl peptidase-4 inhibitors such as teneligliptin can be administered at the usual dose, regardless of a patient's level of renal impairment...
2018: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/29579210/changes-in-prescription-pattern-pharmaceutical-expenditure-and-quality-of-care-after-introduction-of-reimbursement-restriction-in-diabetes-in-korea
#16
Ji-Young Kim, Seung Ju Kim, Chung Mo Nam, Ki Tae Moon, Eun-Cheol Park
Background: To ensure effective prescription practices and reduce diabetes-related pharmaceutical expenditures, Korea adopted a clinical practice guideline for the reimbursement system. Health care providers cannot receive reimbursement from National Health Insurance(NHI) unless it is for an appropriate prescription under the predefined clinical condition. The aim of this study was to evaluate prescription patterns in oral hypoglycemic agents, costs and effects on patient care since the introduction of the diabetes reimbursement restriction...
April 1, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29571976/the-effect-of-vitamin-c-and-or-e-supplementations-on-type-2-diabetic-adult-males-under-metformin-treatment-a-single-blinded-randomized-controlled-clinical-trial
#17
Ali Abd El-Aal, Eman A Abd El-Ghffar, Asmaa Abu Ghali, Mohammed R Zughbur, Mahmoud M Sirdah
BACKGROUND AND AIM: Recently, there has been an increasing interest in the influence of antioxidant vitamins on the efficacy of oral hypoglycemic therapy in type 2 diabetic patients (T2DM). This single-blinded randomized controlled clinical trial aimed to investigate the effect of vitamin C and/or E supplementation on the efficacy of oral hypoglycemic therapy in T2DM Palestinian male patients from the Gaza Strip. METHODS: Forty T2DM male patients aged 40-60 years on metformin treatment were randomly divided into four groups, each group received an additional one of the following daily oral supplements for 90 days: placebo; vitamin C; vitamin E and vitamin C plus vitamin E...
March 16, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29564756/oxysterol-species-reliable-markers-of-oxidative-stress-in-diabetes-mellitus
#18
A Samadi, A Gurlek, S N Sendur, S Karahan, F Akbiyik, I Lay
PURPOSE: To assess the plasma oxysterol species 7-ketocholesterol (7-Kchol) and cholestane-3β,5α,6β-triol (chol-triol) as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus (DM). METHODS: In total, 26 type 1 and 80 type 2 diabetes patients, along with 205 age- and gender-matched healthy controls, were included in this study. Oxysterols were quantified by liquid chromatography coupled with tandem mass spectrometry and N,N-dimethylglycine derivatization...
March 21, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29535949/maternal-and-perinatal-outcome-in-gestational-diabetes-mellitus-in-a-tertiary-care-hospital-in-delhi
#19
Rajesh Kumari, Venus Dalal, Garima Kachhawa, Ipshita Sahoo, Rajesh Khadgawat, Reeta Mahey, Vidushi Kulshrestha, Perumal Vanamail, J B Sharma, Neerja Bhatla, Alka Kriplani
Background: Gestational diabetes mellitus (GDM) is defined as a carbohydrate intolerance first diagnosed in pregnancy and may be associated with adverse maternal and perinatal outcome. Aim: The aim of the study was to determine the maternal and perinatal outcome in GDM during pregnancy. Materials and Methods: It is a retrospective analysis of women diagnosed with GDM who got antenatal care and delivered in our hospital in previous 5 years...
January 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29524188/adverse-drug-events-associated-with-low-dose-10-mg-versus-high-dose-25-mg-empagliflozin-in-patients-treated-for-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Xia Dai, Zu-Chun Luo, Lu Zhai, Wen-Piao Zhao, Feng Huang
INTRODUCTION: Empagliflozin is a new, emerging oral hypoglycemic agent (OHA) which has shown significant benefits in type 2 diabetes mellitus (T2DM) patients with cardiovascular disease. In this analysis, our aim was to systematically compare the adverse drug events (ADEs) associated with a low (10 mg) versus a high (25 mg) dose of empagliflozin as (1) monotherapy, (2) as an add-on to other OHAs, and (3) as an add-on specifically to metformin, in patients who were treated for T2DM. METHODS: This was a systematic review and meta-analysis of randomized controlled trials that compared empagliflozin 10 mg versus 25 mg in patients who were treated for T2DM and which reported adverse drug reactions as their clinical endpoints...
March 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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