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https://www.readbyqxmd.com/read/28821057/a-cell-penetrating-peptide-mediated-chitosan-nanocarriers-for-improving-intestinal-insulin-delivery
#1
Lei Li, Liaoqing Yang, Manman Li, Liefeng Zhang
To overcome barriers for oral delivery of insulin, the chitosan(CS)-based nanocarriers with a novel cell penetrating peptide (SAR6EW) have been prepared and evaluated in this study. Characterization measurements showed that SAR6EW/CS/insulin-NPs displayed global particles with smooth surfaces and an average diameter about 150nm. The entrapment efficiency and loading rates of insulin were 75.36% and 7.58%, respectively. Insulin could be released constantly from SAR6EW/CS/insulin-NPs in vitro. Furthermore, SAR6EW/CS/insulin-NPs could facilitate the uptake of insulin and induce a significantly higher internalization of insulin via adding clathrin and caveolae mediated endocytosis...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28818805/association-between-consumption-of-private-well-water-contaminated-by-low-levels-of-arsenic-and-dysglycemia-in-a-rural-region-of-quebec-canada
#2
Éric Lampron-Goulet, Fabien Gagnon, Marie-France Langlois
The association between arsenic (As) exposure and diabetes is not clearly defined for populations exposed to low or moderate levels of inorganic As (iAs) in drinking water (< 150µg/L). In the present study, the relationship between iAs concentration in drinking water (contaminated at a median level of 10.5µg/L) or As biomarkers (ie, urine and nails) and diabetes or prediabetes (defined as level of glycosylated hemoglobin - HbA1c - higher than 6%, self-reported diagnosis of diabetes by a physician, or the use of insulin or oral hypoglycemic drugs) was evaluated in 257 adults from Canada...
August 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28816925/treatment-of-diabetic-ketoacidosis-associated-with-antipsychotic-medication-literature-review
#3
Antonia Vuk, Maja Baretic, Martina Matovinovic Osvatic, Igor Filipcic, Nikolina Jovanovic, Martina Rojnic Kuzman
BACKGROUND: The second-generation antipsychotics (SGAs) are associated with metabolic disturbances. Diabetic ketoacidosis (DKA) is a rare, but potentially fatal sign of acute glucose metabolism dysregulation, which may be associated with the use of SGAs. This study aims to review published reports of patients with schizophrenia and antipsychotic drug-associated DKA, focusing on the effective management of both conditions. METHODS: Using a predefined search strategy, we searched PubMed and EMBASE from their inception to July 2016...
August 15, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28810360/habit-strength-as-a-moderator-of-the-association-between-symptoms-of-poor-mental-health-and-unintentional-non-adherence-to-oral-hypoglycemic-medication-in-adults-with-type-2-diabetes
#4
Rachel J Burns, Sonya S Deschênes, Bärbel Knäuper, Norbert Schmitz
This study tested if habit strength for taking oral hypoglycemic medication moderated the association between poor mental health symptoms (i.e. depressive symptoms, diabetes distress) and unintentional non-adherence in 790 adults with type 2 diabetes. Data were cross-sectional. A habit strength × depressive symptom interaction was observed. Depressive symptoms were negatively associated with adherence if habit was weak or of average strength; no association was observed if habit was strong. A similar interaction emerged when diabetes distress was examined...
October 1, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/28804397/impact-of-depression-and-anxiety-disorders-on-adherence-to-oral-hypoglycemics-in-older-adults-with-diabetes-mellitus-in-canada
#5
Lia Gentil, Helen-Maria Vasiliadis, Djamal Berbiche, Michel Préville
The prevalence of diabetes mellitus is increasing in Canada, and nonadherence to oral hypoglycemics is a common problem among older adults. This study aims to document the impact of depression and anxiety disorders on adherence to oral hypoglycemics in older adults with diabetes mellitus. Data used in this study came from the longitudinal Quebec survey on senior's health (Enquête sur la Santé des Ainés), using a representative sample of 2811 older adults aged 65 and over. The final sample for analysis consisted of 301 patients who received oral hypoglycemic pharmacotherapy...
June 2017: European Journal of Ageing
https://www.readbyqxmd.com/read/28800543/hypoglycemic-and-hypolipidemic-effects-of-aqueous-extract-of-phaseolus-vulgaris-pods-in-streptozotocin-diabetic-rats
#6
Mohammad Faisal Almuaigel, Mosaad A Seif, Hamad Waleed Albuali, Omar Alharbi, Amer Alhawash
The present investigation was carried out to evaluate the reduction potential of aqueous extract of casing of pods of phaseolus vulgaris in blood glucose and lipids levels among hyperglycemic streptozotocin (STZ)-induced rats. Oral administration of 150mg/kg of aqueous oral administration of aqueous pod extract of phaseolus vulgaris to diabetic rats for 40days resulted in a significant decrease in blood glucose (p<001), cholesterol (P<0.01) and triglycerides (P<0.01). In addition, glibenclamide reduced blood glucose, cholesterol and triglycerides...
August 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28800002/finding-the-sweet-spot-for-metformin-in-18f-fdg-pet
#7
Michael Morris, Babak Saboury, Wengen Chen, Eliot L Siegel, Bahar Dasgeb
PURPOSE: The effect of oral hypoglycemic agents on fluorine-18-flurodeoxyglucose (F-FDG) uptake is less understood than the effect of exogenous insulin. In this study, the effect of withholding metformin on F-FDG distribution in subsequent PET imaging was evaluated. PATIENTS AND METHODS: A retrospective observational study was carried out. A total of 15 patients taking metformin were grouped according to the time interval from the last dose of metformin to F-FDG-PET...
August 10, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28797815/structure-of-a-pectic-polysaccharide-from-pseudostellaria-heterophylla-and-stimulating-insulin-secretion-of-ins-1-cell-and-distributing-in-rats-by-oral
#8
Jinlong Chen, Wensheng Pang, Yongjun Kan, Li Zhao, Zhaodong He, Wentao Shi, Bin Yan, Hong Chen, Juan Hu
A water-soluble, pectic polysaccharide named as 0.5MSC-F isolated from Pseudostellaria Heterophylla with a molecular weight of 4.8×10(4) Da that was composed of rhamnose, galactose, arabinose, and galacturonic acid which the major monosaccharide contents range up to 63.20%. Where the main chain was consists of 1,4-linked galacturonic acid and a small amount of 1,2-linked rhamnose was embedded into backbone to connect alternative galacturonic acid in the form of Rhamnogalacturonan I (RG-I) structure. 1, 5-linked arabinose through C-4 of 1, 2-linked rhamnose, another 1, 3 or 1,6-linked galactose through C-4 of 1, 2-linked rhamnose, was interconnected to branch chain...
August 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28795025/sub-chronic-safety-evaluation-of-aqueous-extract-of-alangium-salvifolium-l-f-wangerin-leaves-in-rats
#9
Bhupinder Kapoor, Gagandeep Kaur, Mukta Gupta, Reena Gupta
Conventionally, the juice and extract of Alangium salvifolium leaves have been used for the treatment of diabetes, wound healing, dog bite, and as a poultice in rheumatism. To carry out the sub-chronic toxicity and thereafter safety evaluation of A. salvifolium leaves. The aqueous extract of A. salvifolium leaves was administered orally at the doses of 200, 400, and 800 mg/kg/day for 90 days. All the animals were observed daily for general behavior, changes in body weight, food, and water consumption. At the end of the treatment period, biochemical and hematological parameters were analyzed; and the animals were sacrificed for histopathological examination of heart, lungs, liver, and kidney...
July 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28792708/correlation-of-fasting-versus-postprandial-plasma-glucose-with-hba1c-in-chinese-type-2-diabetic-patients-taking-different-hypoglycemic-agents
#10
Xiang Wang, Fang Wang, Haifeng Wang, Nan Li
BACKGROUND: Currently, it is not well understood how the contribution of basal versus postprandial plasma glucose changes in the management of type 2 diabetes mellitus (DM) with different treatment regimens. This study aimed to investigate the relationships between glycated hemoglobin (HbA1c) and fasting as well as postprandial blood glucose and to determine how these relationships changed during DM progression in Chinese diabetic patients with different treatment regimens. METHODS: Continuous glucose monitoring was conducted in 228 type 2 DM patients with stable glucose levels...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28774842/bioinspired-butyrate-functionalized-nanovehicles-for-targeted-oral-delivery-of-biomacromolecular-drugs
#11
Lei Wu, Min Liu, Wei Shan, Xi Zhu, Lijia Li, Zhirong Zhang, Yuan Huang
Ligand-functionalization can increase the affinity of nanoparticles (NPs) with targeted cells. However, one major defect of ligands still exists in oral administration: limited receptor recognition. The hindrance of mucus network and deactivation of enzymes severely challenge the targeting efficiency of macromolecular ligands. Inspired by "molecular exchange" between intestinal microbiota and host cells, we anchored microbiota metabolite butyrate on classical "mucus-inert" polyethylene glycol (PEG) NPs. Butyrate has unique advantages of low molecule weight, high hydrophilicity and chemical stability...
August 1, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28762929/-risk-factors-of-cardiovascular-complications-after-beating-heart-coronary-artery-bypass-grafting-in-patients-with-type-two-diabetes
#12
S Y Borodashkina, K V Protasov, V A Podkamennyi
AIM: to determine risk factors of early cardiovascular complications after beating-heart coronary artery bypass grafting (CABG) in patients with ischemic coronary disease (IHD) and type two diabetes (D2). MATERIALS AND METHODS: We included into this study 188 patients (mean age 59 years, 85.1% men) with IHD and D2 who underwent off-pump CABG. The following cardiovascular complications (CVC) registered within 7 days after surgery were analyzed: myocardial infarction (MI), stroke/transient ischemic attack (S/TIA), atrial fibrillation (AF)...
March 2017: Kardiologiia
https://www.readbyqxmd.com/read/28761573/safety-efficacy-and-bioavailability-of-fixed-dose-combinations-in-type-2-diabetes-mellitus-a-systematic-updated-review
#13
REVIEW
Thangavel Mahalingam Vijayakumar, Jayasutha Jayram, Vishnu Meghana Cheekireddy, Dasari Himaja, Yalamanchili Dharma Teja, Damodharan Narayanasamy
PURPOSE: Type 2 diabetes mellitus (T2DM) is a multifactorial disease characterized by insulin resistance. As time progresses, monotherapy often does not provide effective glycemic control, generating the need for an add-on therapy. Hence, multiple oral hypoglycemic agents formulated as a single-dose form called fixed-dose combinations (FDCs) play an essential role in glycemic control. The purpose of this systematic review is to appraise the recently published evidence on the safety, efficacy, and bioavailability of FDCs...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28751547/defects-in-%C3%AE-cell-function-in-patients-with-diabetes-due-to-chronic-pancreatitis-compared-with-patients-with-type-2-diabetes-and-healthy-individuals
#14
Lena Mumme, Thomas G K Breuer, Stephan Rohrer, Nina Schenker, Björn A Menge, Jens J Holst, Michael A Nauck, Juris J Meier
OBJECTIVE: Diabetes frequently develops in patients with chronic pancreatitis. We examined the alterations in the glucagon response to hypoglycemia and to oral glucose administration in patients with diabetes due to chronic pancreatitis. RESEARCH DESIGN AND METHODS: Ten patients with diabetes secondary to chronic pancreatitis were compared with 13 patients with type 2 diabetes and 10 healthy control subjects. A stepwise hypoglycemic clamp and an oral glucose tolerance test (OGTT) were performed...
July 27, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28750941/acute-and-sub-chronic-toxicity-studies-of-the-aqueous-extract-from-leaves-of-cistus-ladaniferus-l-in-mice-and-rats
#15
Mohamed El Kabbaoui, Alae Chda, Jamila El-Akhal, Ouarda Azdad, Najlae Mejrhit, Lotfi Aarab, Rachid Bencheikh, Abdelali Tazi
ETHNOPHARMACOLOGICAL RELEVANCE: Cistus ladaniferus L. (C.ladaniferus) (Cistaceae) is an aromatic shrub native to the Mediterranean region. The leaves are widely used in traditional medicine throughout Morocco for the treatment of various diseases including, diabetes, diarrhea, inflammation, and skin ailments. However, to the best of our knowledge, no systematic study concerning its toxicity profile has been reported. AIM OF THE STUDY: The study carried out evaluates the potential toxicity of the aqueous extract from leaves of the C...
July 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28748191/the-yin-and-yang-between-plasma-glucose-levels-and-cortisol-replacement-therapy-in-schmidt-s-syndrome
#16
Christopher A Newton, Eleni Sheehan, Kathleen Wyne, Kenneth Cusi, Julio Leey, Hans K Ghayee
Objective: To illustrate how steroid replacement in adrenal insufficiency can influence the development of hypoglycemia in a patient with type 1 diabetes mellitus (T1D). Methods: We describe the case of a 36-year-old female patient with T1D and Addison's disease (Schmidt's syndrome) on multiple daily insulin injections who presented with recurrent hypoglycemia despite being on physiological replacement doses of hydrocortisone. Results: With the assistance of continuous glucose monitoring technology, a pattern of nocturnal hypoglycemia was clearly identified...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28744906/effects-of-combination-of-mitiglinide-with-various-oral-antidiabetic-drugs-in-streptozotocin-nicotinamide-induced-type-2-diabetic-rats-and-zucker-fatty-rats
#17
Kenji Akahane, Kazuma Ojima, Ayaka Yokoyama, Toshihiro Inoue, Sumiyoshi Kiguchi, Satoshi Tatemichi, Hiroo Takeda, Yohsuke Imai
We examined the effects of combining the rapid insulin secretagogue, mitiglinide, with various oral hypoglycemic drugs including biguanides, pioglitazone, α-glucosidase inhibitors, and sodium-glucose co-transporter 2 inhibitors in a rat model of type 2 diabetes. The oral glucose tolerance test (OGTT) using glucose, sucrose, or a liquid meal was used to compare the effects of mitiglinide with those of the four oral hypoglycemic drugs and examine their combined effects on blood glucose levels and insulin secretion in the rat model...
July 26, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28740392/cholecalciferol-improves-glycemic-control-in-type-2-diabetic-patients-a-6-month-prospective-interventional-study
#18
Aml Mohamed Nada, Dalia A Shaheen
BACKGROUND AND PURPOSE: To investigate the effects of vitamin D supplementation on glucose homeostasis and lipid profile in type 2 diabetic patients who have vitamin D deficiency. PATIENTS AND METHODS: One hundred twenty-five type 2 diabetic patients taking oral hypoglycemic agents as mono- or combination therapy were recruited from the diabetes and endocrinology clinic. Subject demographics, duration of diabetes, antidiabetic medication, body mass index (BMI), pulse, and blood pressure (BP) were assessed...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28739387/effect-of-cortex-mori-on-pharmacokinetic-profiles-of-main-isoflavonoids-from-pueraria-lobata-in-rat-plasma
#19
Bingxin Xiao, Zengxian Sun, Shu Yang Sun, Jie Dong, Yanli Li, Shan Gao, Jie Pang, Qi Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Radix pueraria (the root of pueraria lobata (Wild.) Ohwi.), which contains a class of isoflavonoids as the main active components, as well as cortex mori (the root bark of Morus alba L), which contains abundant active alkaloids, have been employed for the treatment of diabetes in traditional Chinese medicine for centuries. In previous studies, pharmacodynamic synergistic reactions have been observed in compatible application of pueraria lobata isoflavonoids extracts (PLF) and cortex mori alkaloids extracts (CME) for inhibiting α-glycosidase activity...
July 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28717973/design-and-development-of-repaglinide-microemulsion-gel-for-transdermal-delivery
#20
Ujwala A Shinde, Sheela H Modani, Kavita H Singh
Microemulsion formulation of repaglinide, a BCS class II hypoglycemic agent with limited oral bioavailability, was developed considering its solubility in various oils, surfactants, and cosurfactants. The pseudo-ternary phase diagrams for microemulsion regions were constructed by water titration method at K m 1:1 and characterized for optical birefringence, percentage transmittance, pH, refractive index, globule size, zeta potential, viscosity, drug content, and thermodynamic stability. To enhance the drug permeation and residence time, the optimized microemulsions having mean globule size of 36...
July 17, 2017: AAPS PharmSciTech
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