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Subtle energies

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https://www.readbyqxmd.com/read/29451936/subtle-lisfranc-injuries-a-topical-review-and-modification-of-the-classification-system
#1
Brahman S Sivakumar, Vincent V G An, Colby Oitment, Mark Myerson
Lisfranc injuries are relatively uncommon. No specific incidence of subtle injuries has been reported; however, almost one-third are missed on initial review. These missed injuries are a common cause of litigation. Although seen in high-energy injuries with direct application of forces, they are also associated with lower-energy indirect mechanisms, often on the athletic field. This article provides a topical review of subtle Lisfranc disruptions, focusing on contemporary perspectives, and describes a modification to the most prevalent classification system...
February 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29445244/permeability-and-ammonia-selectivity-in-aquaporin-tip2-1-linking-structure-to-function
#2
Viveca Lindahl, Pontus Gourdon, Magnus Andersson, Berk Hess
Aquaporin TIP2;1 is a protein channel permeable to both water and ammonia. The structural origin of ammonia selectivity remains obscure, but experiments have revealed that a double mutation renders it impermeable to ammonia without affecting water permeability. Here, we aim to reproduce and explain these observations by performing an extensive mutational study using microsecond long molecular dynamics simulations, applying the two popular force fields CHARMM36 and Amber ff99SB-ILDN. We calculate permeabilities and free energies along the channel axis for ammonia and water...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29414859/the-assessment-of-bone-regulatory-pathways-bone-turnover-and-bone-mineral-density-in-vegetarian-and-omnivorous-children
#3
Jadwiga Ambroszkiewicz, Magdalena Chełchowska, Katarzyna Szamotulska, Grażyna Rowicka, Witold Klemarczyk, Małgorzata Strucińska, Joanna Gajewska
Vegetarian diets contain many beneficial properties as well as carry a risk of inadequate intakes of several nutrients important to bone health. The aim of the study was to evaluate serum levels of bone metabolism markers and to analyze the relationships between biochemical bone markers and anthropometric parameters in children on vegetarian and omnivorous diets. The study included 70 prepubertal children on a lacto-ovo-vegetarian diet and 60 omnivorous children. Body composition, bone mineral content (BMC), and bone mineral density (BMD) were assessed by dual-energy X-ray absorptiometry...
February 7, 2018: Nutrients
https://www.readbyqxmd.com/read/29412644/conformational-entropy-of-fk506-binding-to-fkbp12-determined-by-nmr-relaxation-and-molecular-dynamics-simulations
#4
Gleb Solomentsev, Carl Diehl, Mikael Akke
FKBP12 (FK506 binding protein 12 kDa) is an important drug target that attracts a great deal of interest as a model system for computational drug design and studies on the role of protein dynamics in ligand binding. NMR spectroscopy is uniquely suited to experimentally probe protein dynamics on a wide range of timescales. Order parameters, describing amplitudes of motion on the pico- to nanosecond timescale, take a central role because they are often used to validate molecular dynamics simulations and can provide estimates of the conformational entropy...
February 7, 2018: Biochemistry
https://www.readbyqxmd.com/read/29409868/structure-and-collagen-crimp-patterns-of-functionally-distinct-equine-tendons-revealed-by-quantitative-polarised-light-microscopy-qplm
#5
Ewa M Spiesz, Chavaunne T Thorpe, Philipp J Thurner, Hazel R C Screen
Structure-function relationships in tendons are directly influenced by the arrangement of collagen fibres. However, the details of such arrangements in functionally distinct tendons remain obscure. This study demonstrates the use of quantitative polarised light microscopy (qPLM) to identify structural differences in two major tendon compartments at the mesoscale: fascicles and interfascicular matrix (IFM). It contrasts functionally distinct positional and energy storing tendons, and considers changes with age...
January 31, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29380073/threshold-response-and-bistability-in-gene-regulation-by-small-noncoding-rna
#6
Sutapa Mukherji
In this paper, we study through mathematical modelling the combined effect of transcriptional and translational regulation by proteins and small noncoding RNAs (sRNA) in a genetic feedback motif that has an important role in the survival of E. coli under stress associated with oxygen and energy availability. We show that subtle changes in this motif can bring in drastically different effects on the gene expression. In particular, we show that a threshold response in the gene expression changes to a bistable response as the regulation on sRNA synthesis or degradation is altered...
January 31, 2018: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29369442/negative-nucleotide-ions-as-sensitive-probes-for-energy-specificity-in-collision-induced-fragmentation-in-mass-spectrometry
#7
Stefanie Ickert, Jens Riedel, Sebastian Beck, Michael W Linscheid
RATIONALE: The most commonly used fragmentation methods in tandem MS are CID and HCD. While in CID, the preselected ions in the trap are resonantly (and m/z exclusively) excited, in HCD the entire m/z range experiences the dissociative acceleration. The different excitation is reflected in different fragment distributions. METHODS: As a test-bed for particularly pronounced fragmentation specificity, here MS/MS experiments on several 4-mer oligonucleotides were conducted employing both collision methods and the results were thoroughly compared...
January 25, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29347619/topological-defects-in-an-unconfined-nematic-fluid-induced-by-single-and-double-spherical-colloidal-particles
#8
Yiwei Wang, Pingwen Zhang, Jeff Z Y Chen
We present numerical solutions to the Landau-de Gennes free-energy model under the one-constant approximation for systems of single and double spherical colloidal particles immersed in an otherwise uniformly aligned nematic liquid crystal. A perfect homeotropic surface anchoring of liquid-crystal molecules on the spherical surface is considered. A large parameter space is carefully examined, including those in the free-energy model and those describing the dimer configurations and the background liquid-crystal orientation...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29323663/multiplexed-proteome-analysis-with-neutron-encoded-stable-isotope-labeling-in-cells-and-mice
#9
Katherine A Overmyer, Stefka Tyanova, Alex S Hebert, Michael S Westphall, Jürgen Cox, Joshua J Coon
We describe a protocol for multiplexed proteomic analysis using neutron-encoded (NeuCode) stable isotope labeling of amino acids in cells (SILAC) or mice (SILAM). This method currently enables simultaneous comparison of up to nine treatment and control proteomes. Another important advantage over traditional SILAC/SILAM is that shorter labeling times are required. Exploiting the small mass differences that correspond to subtle differences in the neutron-binding energies of different isotopes, the amino acids used in NeuCode SILAC/SILAM differ in mass by just a few milliDaltons...
January 2018: Nature Protocols
https://www.readbyqxmd.com/read/29313040/a-computational-exploration-of-the-crystal-energy-and-charge-carrier-mobility-landscapes-of-the-chiral-6-helicene-molecule
#10
Beth Rice, Luc M LeBlanc, Alberto Otero-de-la-Roza, Matthew J Fuchter, Erin R Johnson, Jenny Nelson, Kim E Jelfs
The potential of a given π-conjugated organic molecule in an organic semiconductor device is highly dependent on molecular packing, as it strongly influences the charge-carrier mobility of the material. Such solid-state packing is sensitive to subtle differences in their intermolecular interactions and is challenging to predict. Chirality of the organic molecule adds an additional element of complexity to intuitive packing prediction. Here we use crystal structure prediction to explore the lattice-energy landscape of a potential chiral organic semiconductor, [6]helicene...
January 9, 2018: Nanoscale
https://www.readbyqxmd.com/read/29290559/parallel-saltational-evolution-of-ultrafast-movements-in-snapping-shrimp-claws
#11
Tomonari Kaji, Arthur Anker, Christian S Wirkner, A Richard Palmer
How do stunning functional innovations evolve from unspecialized progenitors? This puzzle is particularly acute for ultrafast movements of appendages in arthropods as diverse as shrimps [1], stomatopods [2], insects [3-6], and spiders [7]. For example, the spectacular snapping claws of alpheid shrimps close so fast (∼0.5 ms) that jetted water creates a cavitation bubble and an immensely powerful snap upon bubble collapse [1]. Such extreme movements depend on (1) an energy-storage mechanism (e.g., some kind of spring) and (2) a latching mechanism to release stored energy quickly [8]...
December 27, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29290371/mitochondrial-etiology-of-neuropsychiatric-disorders
#12
REVIEW
Liming Pei, Douglas C Wallace
The brain has the highest mitochondrial energy demand of any organ. Therefore, subtle changes in mitochondrial energy production will preferentially affect the brain. Considerable biochemical evidence has accumulated revealing mitochondrial defects associated with neuropsychiatric diseases. Moreover, the mitochondrial genome encompasses over a thousand nuclear DNA genes plus hundreds to thousands of copies of the maternally inherited mitochondrial DNA (mtDNA). Therefore, partial defects in either the nuclear DNA or mtDNA genes or combinations of the two can be sufficient to cause neuropsychiatric disorders...
November 20, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29285575/alteration-of-gray-matter-texture-features-over-the-whole-brain-in-medication-overuse-headache-using-a-3-dimentional-texture-analysis
#13
Zhiye Chen, Xiaoyan Chen, Zhiqiang Chen, Mengqi Liu, Huiguang He, Lin Ma, Shengyuan Yu
BACKGROUND: Imaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR structural images over the whole brain in MOH using a 3-dimentional texture analysis. METHODS: Brain three-dimensional T1-weighted structural images were obtained from 44 MOH patients and 32 normal controls (NC). The imaging processing included two steps: gray matter (gray images) segment and a 3-dimensional texture features mapping...
November 28, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29246279/indirect-calorimetry-using-a-ventilated-hood-may-be-easier-than-using-a-facemask-to-achieve-steady-state-when-measuring-resting-energy-expenditure
#14
Xi Wang, Yuan Wang, Zuchang Ma, Yang Xu, Qingyuan Wu
Previous studies have demonstrated differences in subjective comfort between different gas collecting methods during resting energy expenditure (REE) measurement. We hypothesized that gas collecting methods may have an influence on the time to achieve steady state and the optimum abbreviated period to estimate REE. Gas exchange variables were obtained using IIM-IC-100 (ventilated hood) and VO2000 (facemask) alternately among 32 healthy adults. A 10-minute test period was divided into 5-minute sliding time windows to obtain a subtle profile process of the coefficient of variation (CV) and REE...
December 2017: Nutrition Research
https://www.readbyqxmd.com/read/29246050/accelerated-path-integral-simulations-using-ring-polymer-interpolation
#15
Samuel J Buxton, Scott Habershon
Imaginary-time path-integral (PI) molecular simulations can be used to calculate exact quantum statistical mechanical properties for complex systems containing many interacting atoms and molecules. The limiting computational factor in a PI simulation is typically the evaluation of the potential energy surface (PES) and forces at each ring-polymer "bead"; for an n-bead ring-polymer, a PI simulation is typically n times greater than the corresponding classical simulation. To address the increased computational effort of PI simulations, several approaches have been developed recently, most notably based on the idea of ring-polymer contraction which exploits either the separation of the PES into short-range and long-range contributions or the availability of a computationally inexpensive PES which can be incorporated to effectively smooth the ring-polymer PES; neither approach is satisfactory in applications to systems modeled by PESs given by on-the-fly ab initio calculations...
December 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29234986/exertional-rhabdomyolysis-leading-to-acute-kidney-injury-when-genetic-defects-are-diagnosed-in-adult-life
#16
David Cucchiari, Irene Colombo, Ottavia Amato, Manuel Alfredo Podestà, Francesco Reggiani, Rossella Valentino, Irene Faravelli, Silvia Testolin, Maurizio Moggio, Salvatore Badalamenti
Rhabdomyolysis is a common cause of acute kidney injury (AKI) that is usually triggered by trauma. However, less common causes of rhabdomyolysis may precipitate AKI as well, possibly representing a diagnostic challenge even for the experienced nephrologist. Genetic defects of muscle metabolism represent one of these causes and can be overlooked in adults, since these diseases usually become apparent in childhood. We present here a case in which an adult patient with severe exertional rhabdomyolysis leading to AKI was finally diagnosed with a genetic defect of lipid metabolism...
December 12, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/29229525/examining-water-in-model-membranes-by-near-infrared-spectroscopy-and-multivariate-analysis
#17
Jorge J Wenz
By exploiting the sensitivity of the NIR spectrum, particularly the first overtone of water, to the number and strength of hydrogen bonds, the hydrogen bond network and water polymerization in membranes of DMPA (1,2-dimyristoyl-sn-glycero-3-phosphate) and DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) was investigated as a function of the temperature and the presence of this two phospholipids having the same tail but different polar head. Principal components analysis performed on the spectra was used to disclose subtle spectral changes that mirror the alteration of the vibrational energy of the water O-H bonds, as a measure of the H-bond network...
December 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29205082/energetic-modalities-as-a-self-care-technique-to-reduce-stress-in-nursing-students
#18
Deborah Kramer
This article describes the outcomes of nursing students taking a course in complementary and alternative therapies focusing on energetic modalities that were used as a means of self-care. Students kept journal logs and did a formal presentation for the class. Nursing students reported decreased stress and improved concentration, academic performance, productivity, and problem-solving while experiencing a greater appreciation of their clinical experiences. Using Therapeutic Touch and other subtle energy interactions, the students also cited improved interpersonal relationships, increased feelings of calmness, a higher degree of self-awareness and self-care, reduced physical pain, increased energy, and greater appreciation of the world around them...
December 1, 2017: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
https://www.readbyqxmd.com/read/29185082/multi-energy-spectral-ct-adding-value-in-emergency-body-imaging
#19
Gopal V Punjabi
Most vendors offer scanners capable of dual- or multi-energy computed tomography (CT) imaging. Advantages of multi-energy CT scanning include superior tissue characterization, detection of subtle iodine uptake differences, and opportunities to reduce contrast dose. However, utilization of this technology in the emergency department (ED) remains low. The purpose of this pictorial essay is to illustrate the value of multi-energy CT scanning in emergency body imaging.
November 28, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/29184506/recent-advances-in-the-cellular-and-molecular-mechanisms-of-hypothalamic-neuronal-glucose-detection
#20
Xavier Fioramonti, Chloé Chrétien, Corinne Leloup, Luc Pénicaud
The hypothalamus have been recognized for decades as one of the major brain centers for the control of energy homeostasis. This area contains specialized neurons able to detect changes in nutrients level. Among them, glucose-sensing neurons use glucose as a signaling molecule in addition to its fueling role. In this review we will describe the different sub-populations of glucose-sensing neurons present in the hypothalamus and highlight their nature in terms of neurotransmitter/neuropeptide expression. This review will particularly discuss whether pro-opiomelanocortin (POMC) neurons from the arcuate nucleus are directly glucose-sensing...
2017: Frontiers in Physiology
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