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https://www.readbyqxmd.com/read/28822292/nanoparticles-assemblies-on-demand-controlled-aggregation-of-ag-0-mediated-by-modified-peptoid-sequences
#1
Hagar Tigger-Zaborov, Galia Maayan
Assemblies of metal nanoparticles (NPs) have been broadly used for the construction of materials with distinct spectroscopic properties towards sensing applications. On the other hand, well-dispersed NPs are exploit for applications in catalysis and medicine. Biopolymers or biomimetic oligomers can serve both as efficient stabilizers of NPs and as useful aggregation mediators that can lead to assemblies with unique properties. Controlling aggregation processes, however, is still challenging and often relies on trial and error rather than on defined thumb rules...
August 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28822165/-methodological-quality-assessment-of-community-acquired-pneumonia-clinical-practice-guidelines-in-china-based-on-agree-%C3%A2-tool
#2
Ying-Jie Zhi, Xing Liao, Yan-Ming Xie, De-Min Li, Wei Chen, Yao-Long Chen, Ren-Bo Chen, Ya Yuwen, Hong-Chun Zhang, Yong-Yan Wang
This study is aimed to identify and assess the methodological quality of community-acquired pneumonia (CAP) clinical practice guidelines (CPG) in China by using AGREE Ⅱ tool. CNKI, SinoMed, Wanfang, and VIP Chinese databases from database establishment to March 2017 were searched by manual retrieval to collect all the clinical practice guidelines prepared by various associations or organizations, then AGREE Ⅱtool was used to assess them. Data in each CPG were analyzed in terms of six domains, including scope and purpose, participants, rigor, clarity and readability, applicability and editorial independence...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28821193/therapeutic-plasma-exchange-and-its-impact-on-drug-levels-an-aclps-critical-review
#3
Caleb W Cheng, Jeanne E Hendrickson, Christopher A Tormey, Davinder Sidhu
Objectives: To examine and summarize the current literature on the effects of therapeutic plasma exchange on medication levels. Methods: Literature review was performed via searches of the Cochrane Database and PubMed-MEDLINE (1996 to August 2016) looking for all case reports, case series, and human randomized controlled trials involving therapeutic plasma exchange (TPE)-associated drug removal. Results: Approximately 60 peer-reviewed articles were identified with the majority being case reports; no randomized controlled trials were identified...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28820896/a-strategy-for-scaling-up-access-to-comprehensive-care-in-adults-with-chagas-disease-in-endemic-countries-the-bolivian-chagas-platform
#4
Maria-Jesus Pinazo, Jimy Pinto, Lourdes Ortiz, Jareth Sánchez, Wilson García, Ruth Saravia, Mirko-R Cortez, Silvia Moriana, Enric Grau, Daniel Lozano, Joaquim Gascon, Faustino Torrico
BACKGROUND: Bolivia has the highest prevalence of Chagas disease (CD) in the world (6.1%), with more than 607,186 people with Trypanosoma cruzi infection, most of them adults. In Bolivia CD has been declared a national priority. In 2009, the Chagas National Program (ChNP) had neither a protocol nor a clear directive for diagnosis and treatment of adults. Although programs had been implemented for congenital transmission and for acute cases, adults remained uncovered. Moreover, health professionals were not aware of treatment recommendations aimed at this population, and research on CD was limited; it was difficult to increase awareness of the disease, understand the challenges it presented, and adapt strategies to cope with it...
August 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28820727/sustained-off-treatment-response-after-discontinuation-of-long-term-nucleos-t-ide-analogue-treatment-in-hbeag-seronegative-hepatitis-b-a-case-series
#5
Marion Muche, Ulrike Meyer, Britta Siegmund, Rajan Somasundaram, Hans-Joerg Epple
International guidelines recommend lifelong nucleos(t)ide analogue (NA) treatment in individuals with chronic hepatitis B (CHB) infection who are hepatitis B e antigen (HBeAg) seronegative, because hepatitis B surface antigen (HBsAg) seroconversion is rarely achieved. However, after terminating therapy, sustained responses and HBsAg loss have been observed. Clinical characteristics identifying persons with favorable outcomes after discontinuing NA therapy have not yet been defined. This case series describes outcomes of 6 individuals with HBeAg-seronegative CHB infection without cirrhosis and low plasma levels of HBsAg who discontinued long-term NA treatment...
July 2017: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/28820650/critical-care-nutrition-support-best-practices-key-differences-between-canadian-and-american-guidelines
#6
Jayshil J Patel, Margot Lemieux, Stephen A McClave, Robert G Martindale, Ryan T Hurt, Daren K Heyland
Since 2015, Society of Critical Care Medicine/American Society for Parenteral and Enteral Nutrition and Canadian critical care nutrition support guidelines have both been updated. Despite a similar evidentiary basis, there remain key differences between guideline recommendations. These differences in recommendations may pose confusion for the clinician and may encumber widespread applicability. The aim of this review was to enhance practitioner confidence in applying critical care nutrition support guidelines to patient care in their settings by outlining the similarities and differences between the American and Canadian methods for guideline development and describing the key differences and reasons behind the differences...
August 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28820348/where-to-now-avert-answered-an-important-question-but-raised-many-more
#7
Mark T Bayley, Audrey Bowen, Coralie English, Robert Teasell, Janice J Eng
A Very Early Rehabilitation Trial (AVERT) was a Phase 3 randomized trial with over 2100 subjects post stroke that had unexpected results with better outcomes for usual care than those receiving very early mobilization. This review of published stroke clinical practice guidelines highlights that recommendations for mobilization have changed after publication of AVERT but also that developers have struggled to provide recommendations for appropriate dose, duration and intensity of mobilization in the acute post stroke period with available analyses from AVERT and other literature...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28819961/-bioresorbable-scaffolds-in-the-treatment-of-coronary-artery-disease-expert-consensus-statement-of-the-association-of-cardiovascular-interventions-of-the-polish-cardiac-society-acvi-pcs
#8
Krzysztof Reczuch, Krzysztof Milewski, Wojciech Wąsek, Łukasz Rzeszutko, Wojciech Wojakowski, Michał Hawranek, Adrian Włodarczak, Tomasz Pawłowski, Janusz Kochman, Sławomir Dobrzycki, Marek Grygier, Andrzej Ochała, Jarosław Wójcik, Maciej Lesiak, Dariusz Dudek, Jacek Legutko
Bioresorbable scaffold coated with antimitotic drug is the latest development in the coronary stents technology. The concept of temporary scaffolding and natural vessel healing after angioplasty is a very attractive alternative to conventional metal stents. The results of the first observational studies have confirmed their ultimate biodegradation. Newest results of randomised trials and registries in broader clinical and anatomical indications also revealed the limitations of the first generation of scaffolds...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28819897/teachers-and-parents-perspectives-on-a-curricular-subject-of-religion-and-spirituality-for-indian-schools-a-pilot-study-toward-school-mental-health-program
#9
Parameshwaran Ramakrishnan, Andrew Baccari, Uma Ramachandran, Syed Faiz Ahmed, Harold G Koenig
Religious-spiritual (R/S) education helps medical students cope with caregiving stress and gain skills in interpersonal empathy needed for clinical care. Such R/S education has been introduced into K-12 and college curricula in some developed nations and has been found to positively impact student's mental health. Such a move has not yet been seen in the Indian education system. This paper aimed to examine perspectives of teachers and parents in India on appropriateness, benefits, and challenges of including R/S education into the school curriculum and also to gather their impressions on how a R/S curriculum might promote students' health...
August 17, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28819801/botulinum-toxin-treatment-in-multiple-sclerosis-a-review
#10
REVIEW
Yasaman Safarpour, Tahereh Mousavi, Bahman Jabbari
Purpose of review The purpose of this review is to provide updated information on the role of botulinum neurotoxin (BoNT) therapy in multiple sclerosis (MS). This review aims to answer which symptoms of multiple sclerosis may be amenable to BoNT therapy. Recent findings We searched the literature on the efficacy of BoNTs for treatment of MS symptoms up to April 1st 2017 via the Yale University Library's search engine including but not limited to Pub Med and Ovis SP. The level of efficacy was defined according to the assessment's criteria set forth by the Subcommittee on Guideline Development of the American Academy of Neurology...
August 17, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28819682/laparoscopy-or-laparotomy-as-the-way-of-entrance-in-myoma-enucleation
#11
REVIEW
Cristina Cezar, Sven Becker, Attilio di Spiezio Sardo, Anja Herrmann, Angelika Larbig, Vasilis Tanos, Luz Angela Torres de la Roche, Hugo Christian Verhoeven, Markus Wallwiener, Rudy Leon De Wilde
PURPOSE: Uterine myomas are the main cause of benign uterine diseases in premenopausal women. Objective of the present paper is to investigate the current best treatment modalities of myomas, depending on age of the patient and her desire to preserve fertility, as well as on clinical presentation of this pathology, such as size, number, and location of fibroids and, furthermore, on surgical experience of the gynecologist. METHODS: The design of our work is a systematic literature review of existing studies, reviews, and meta-analysis conducted in PubMed and Cochrane Library to identify relevant literature...
August 17, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28819540/use-of-global-initiative-for-asthma-gina-guidelines-in-asthma-management-among-paediatric-residents-in-a-sub-saharan-african-country-a-cross-sectional-descriptive-study
#12
Adaeze Chikaodinaka Ayuk, Agozie Ubesie, Chioma Laura Odimegwu, Kenechukwu Iloh
INTRODUCTION: Clinical practice guidelines are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. Despite abundance of asthma guidelines, prevalence has continued to increase globally. There is need to assess how the contents of asthma guidelines are put to clinical use by doctors in the management of children with asthma. This study aims at evaluating the clinical practice of paediatric residents in applying GINA guidelines...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28819487/an-evaluation-of-wb123-antibody-elisa-in-individuals-treated-with-ivermectin-and-albendazole-and-implementation-challenges-in-africa
#13
Dziedzom Komi de Souza, Irene Offei Owusu, Joseph Otchere, Michelle Adimazoya, Kwadwo Frempong, Collins Stephen Ahorlu, Daniel Adjei Boakye, Michael David Wilson
The development of antibody testing for the diagnosis of lymphatic filariasis (LF) is intended to enhance the monitoring and evaluation activities of the Global Program for the Elimination of LF. This is due to the fact that antibody tests are expected to be the most sensitive at detecting exposure to LF compared to antigen that takes longer to develop. To this end a new antibody-based enzyme linked immunosorbent assay (ELISA) to Wuchereria bancrofti antigen Wb123 has been developed and further designed into a point of care rapid diagnostic test, under evaluation...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28818842/what-s-new-in-paediatric-hypertension
#14
REVIEW
Rowena Lalji, Kjell Tullus
Paediatric hypertension predisposes to hypertension and cardiovascular disease in adult life. Despite clear guidelines, there remains a lack of screening. Diagnosis remains challenging given the high rate of false-positive high blood pressure (BP) readings at a single visit; thus, multiple visits are required to confirm the diagnosis. Depending on the normative data sets used, hypertension in overweight and obese children can be underestimated by up to 20%. Specific BP targets are required for subgroups such as adolescents, children with chronic kidney disease (CKD) and type 1 diabetes...
August 17, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28818646/best-practice-in-research-consensus-statement-on-ethnopharmacological-field-studies-consefs
#15
REVIEW
Michael Heinrich, Andreas Lardos, Marco Leonti, Caroline Weckerle, Merlin Willcox
BACKGROUND: Ethnopharmacological research aims at gathering information on local and traditional uses of plants and other natural substances. However, the approaches used and the methods employed vary, and while such a variability is desirable in terms of scientific diversity, research must adhere to well defined quality standards and reproducible methods OBJECTIVES: With ConSEFS (the Consensus Statement on Ethnopharmacological Field Studies) we want to define best-practice in developing, conducting and reporting field studies focusing on local and traditional uses of medicinal and food plants, including studies using a historical approach...
August 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28818633/patient-and-caregiver-reported-assessment-tools-for-palliative-care-summary-of-the-2017-ahrq-technical-brief
#16
Rebecca Aslakson, Sydney M Dy, Renee F Wilson, Julie Waldfogel, Allen Zhang, Sarina R Isenberg, Alex Blair, Joshua Sixon, Karen A Robinson
CONTEXT: Assessment tools are data collection instruments that are completed by or with patients or caregivers and which collect data at the individual patient or caregiver level. OBJECTIVES: To (1) summarize palliative care assessment tools completed by or with patients or caregivers, and (2) identify needs for future tool development and evaluation. METHODS: We completed: (1) a systematic review of systematic reviews; (2) a supplemental search of previous reviews and websites, and/or (3) a targeted search for primary articles when no tools existed in a domain...
August 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28818595/fish-embryo-toxicity-test-threshold-approach-and-moribund-as-approaches-to-implement-3r-principles-to-the-acute-fish-toxicity-test
#17
REVIEW
ZhiChao Dang, Leo T M van der Ven, Anne S Kienhuis
The acute fish toxicity test (AFT) is requested by EU legal frameworks for hazard classification and risk assessment. AFT is one of the few regulatory required tests using death as an endpoint. This paper reviews efforts made to reduce, refine and replace (3Rs) AFT. We make an inventory of information requirements for AFT, summarize studies on 3Rs of AFT and give recommendations. The fish embryo toxicity test (FET) is proposed as a replacement of AFT and analyses have focused on two aspects: assessing the capacity of FET in predicting AFT and defining the applicability domain of FET...
August 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28818584/-neonatal-intoxication-to-vitamin-d-in-premature-babies-a-series-of-16%C3%A2-cases
#18
M Vierge, S Laborie, A Bertholet-Thomas, M-C Carlier, J-C Picaud, O Claris, J Bacchetta
INTRODUCTION: Preterm neonates are particularly at risk of vitamin D (25-D) deficiency. To prevent rickets and osteopenia in this population, international guidelines vary between 800 and 1000IU per day of vitamin D in Europe and recommend 400IU per day in the USA. Target levels of circulating 25-D are not well identified, with the lower target level 50-75nmol/L and the upper target level probably 120nmol/L. METHODS: Between 2013 and 2015, 16 premature infants (born<35WG) were referred to pediatric nephrology clinics because of symptoms secondary to 25-D overdose during the neonatal period...
August 14, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28818450/development-and-delivery-of-a-physiotherapist-led-exercise-intervention-in-a-randomised-controlled-trial-for-subacromial-impingement-syndrome-the-support-trial
#19
Kay Stevenson, Sue Jackson, Julie Shufflebotham, Edward Roddy, Nadine E Foster
PURPOSE: This paper describes the development, content and delivery of a physiotherapist- led individualised, supervised and progressed exercise programme for use in a factorial randomised controlled trial testing treatments for subacromial impingement syndrome. METHODS: To develop the intervention, a survey of community physiotherapists and national guidelines provided the basis for a consensus workshop through which a protocol was developed for the SUPPORT trial physiotherapist-led exercise programme (SUPPORT: SUbacromial impingement syndrome and Pain: a randomised controlled trial Of exeRcise and injection)...
March 24, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28818361/strategy-for-patients-with-co-existence-of-meningioma-and-intracerebral-aneurysm-especially-unruptured-aneurysm-seven-cases-and-review-of-the-literature
#20
Naoya Takeda, Masamitsu Nishihara, Shunsuke Yamanishi, Keiji Kidoguchi, Kimio Hashimoto
BACKGROUND: Intracerebral aneurysms co-existing with meningiomas are rare. Treatment strategies for intracerebral aneurysms co-existing with meningiomas have not yet been established. METHODS: We studied 62 patients with intracerebral aneurysms co-existing with meningiomas in the literature including our seven cases, evaluated the various managements and outcomes, and discussed the strategy for intracerebral aneurysms, especially unruptured cases, co-existing with meningiomas...
August 14, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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