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visual analytics

Priti Sengupta, Aniruddha Ganguly, Adity Bose
The crucial role of chemosensor for the immediate recognition of environment pollutant motivates the researchers to develop variety of sensing protocols. Of various chemosensory protocols, the colour change observed by the naked eye is considered to be a conceivable and on-site way to indicate the presence of an analyte. We herein report a colourimetric and commercially available absorption probe, sinapic acid (SA) that is completely ready to use for "on-site" visual determination of copper ions. The molecule, SA is well-known phenolic acid, often utilized for its antibacterial activity...
March 3, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Qi Sui, Peng Li, Ning-Ning Yang, Teng Gong, Ran Bu, En-Qing Gao
Since amines have high toxicity and exist widely, the development of selective sensing materials for amine detection has received considerable attentions. In this article, we demonstrate for the first time that a degree of discriminative detection of alkylamines can be achieved by a metal-organic coordination material. The material is derived from CdII and 4,4'-bipyridinium-1,1'-bis(phenylene-3-carboxylate), shows 1D channels lined with electron-deficient viologen chromophores, and exhibits different colors upon contact with amine vapors of different molecular sizes and types (primary, secondary and tertiary)...
March 16, 2018: ACS Applied Materials & Interfaces
Cheng-Han Wu, Bang-Hung Yang, Yuan-Hwa Chou, Shyh-Jen Wang, Jyh-Cheng Chen
99mTc-TRODAT-1 is a type of drug that can bind to dopamine transporters in living organisms and is often used in SPCT imaging for observation of changes in the activity uptake of dopamine in the striatum. Therefore, it is currently widely used in studies on clinical diagnosis of Parkinson's disease (PD) and movement-related disorders. In conventional 99mTc-TRODAT-1 SPECT image evaluation, visual inspection or manual selection of ROI for semiquantitative analysis is mainly used to observe and evaluate the degree of striatal defects...
2018: PloS One
V A Shaimova, T B Shaimov, R B Shaimov, A Yu Galin, Zh A Goloshchapova, P K Ryzhkov, A V Fomin
PURPOSE: To develop methods for evaluating effectiveness of YAG-laser vitreolysis of vitreous floaters. MATERIAL AND METHODS: The study included 144 patients (173 eyes) who had underwent YAG-laser vitreolysis and were under observation from 01.09.16 to 31.01.18. The patients were 34 to 86 years old (mean age 62.7±10.2 years), 28 (19.4%) patients were male, 116 (80.6%) - female. All patients underwent standard and additional examination: ultrasonography (Accutome B-scan plus, U...
2018: Vestnik Oftalmologii
Sean T Vittadello, Scott W McCue, Gency Gunasingh, Nikolas K Haass, Matthew J Simpson
The fluorescent ubiquitination-based cell cycle indicator, also known as FUCCI, allows the visualization of the G1 and S/G2/M cell cycle phases of individual cells. FUCCI consists of two fluorescent probes, so that cells in the G1 phase fluoresce red and cells in the S/G2/M phase fluoresce green. FUCCI reveals real-time information about cell cycle dynamics of individual cells, and can be used to explore how the cell cycle relates to the location of individual cells, local cell density, and different cellular microenvironments...
March 13, 2018: Biophysical Journal
Chao Zhang, Caoqi Fan, Jingbo Gan, Ping Zhu, Lei Kong, Cheng Li
Transcriptome sequencing (RNA-seq) is becoming a standard experimental methodology for genome-wide characterization and quantification of transcripts at single base-pair resolution. However, downstream analysis of massive amount of sequencing data can be prohibitively technical for wet-lab researchers. A functionally integrated and user-friendly platform is required to meet this demand. Here, we present iSeq, an R-based Web server, for RNA-seq data analysis and visualization. iSeq is a streamlined Web-based R application under the Shiny framework, featuring a simple user interface and multiple data analysis modules...
2018: Methods in Molecular Biology
Lei Mai, Lian-Jun Bao, Lei Shi, Charles S Wong, Eddy Y Zeng
An increasing number of reports have been published concerning microplastic (MP) pollution in aquatic environments. Methods used in these studies continue to be updated and lack standardization, so that an up-to-date review pertaining methods for MP research is needed. This critical review examines the analytical methods, including sampling, identification, and quantitation, for MP research. Samples are generally collected from water, sediment, and biota gastrointestinal tract. Manta nets or trawls are prevalently used in surface water sampling, while direct shoveling or box-corer grab are commonly applied in sediment sampling...
March 13, 2018: Environmental Science and Pollution Research International
Fatemeh Khadjevand, Jan Cimbalnik, Gregory A Worrell
High-frequency oscillations (HFOs: 100 - 600 Hz) have been widely proposed as biomarkers of epileptic brain tissue. In addition, HFOs over a broader range of frequencies spanning 30 - 2000 Hz are potential biomarkers of both physiological and pathological brain processes. The majority of the results from humans with focal epilepsy have focused on HFOs recorded directly from the brain with intracranial EEG (iEEG) in the high gamma (65 - 100 Hz), ripple (100 - 250 Hz), and fast ripple (250 - 600 Hz) frequency ranges...
December 2017: Current Opinion in Biomedical Engineering
Justin A Haegele, T Nicole Kirk
The purpose of this study was to adopt an explicitly intersectional approach to examine the embodied perspectives of males with visual impairments about physical education. An interpretative phenomenological analysis research approach was used, and six adults (18-33 years) who identified as males with visual impairments acted as participants. The primary sources of data were semistructured, audiotaped, telephone interviews and reflective field notes. Thematic development utilized a four-step interpretative phenomenological analysis-guided analytical process...
March 13, 2018: Adapted Physical Activity Quarterly: APAQ
Davinia Brouckaert, Laurens De Meyer, Brecht Vanbillemont, Pieter-Jan Van Bockstal, Joris Lammens, Severine Therese F C Mortier, Jos Corver, Chris Vervaet, Ingmar Nopens, Thomas De Beer
Near-infrared chemical imaging (NIR-CI) is an emerging tool for process monitoring, since it combines the chemical selectivity of vibrational spectroscopy with spatial information. Whereas traditional near-infrared spectroscopy is an attractive technique for water content determination and solid-state investigation of lyophilized products, chemical imaging opens up possibilities for assessing the homogeneity of these critical quality attributes (CQAs) throughout the entire product. In this contribution, it is aimed to evaluate NIR-CI as a process analytical technology (PAT) tool for at-line inspection of continuously freeze-dried pharmaceutical unit doses, based on spin freezing...
March 12, 2018: Analytical Chemistry
Takayuki Iida, Koji Ohara, Yuriy Román-Leshkov, Toru Wakihara
Zeolites containing framework heteroatoms (e.g., Ti, Sn, and Hf) with open coordination sites behave as solid-state Lewis acids and exhibit remarkable catalytic properties unachievable with bulk oxides. However, direct evidence confirming the incorporation of such heteroatom species into the zeolite framework is difficult to obtain because of the limited number of analytical methods capable of discerning framework incorporation from extraframework species. In this work, the structural environments of hafnium (Hf) framework and extraframework species added post-synthetically into *BEA zeolites were analyzed using coupled pair distribution function (PDF) and diffuse reflectance (DR) UV-vis measurements...
March 12, 2018: Physical Chemistry Chemical Physics: PCCP
Minhui He, Qiong Hu, Yaqi Mei, Baojing Zhou, Jinming Kong, Xueji Zhang
The ability to directly detect alkaline phosphatase (ALP) activity in undiluted serum samples is of great importance for clinical diagnosis. In this work, we report the use of the distinctive metal-to-ligand charge-transfer (MLCT) absorption properties of the Cu(BCA)2 + (BCA = bicinchoninic acid) reporter for the visual detection of ALP activity. In the presence of ALP, the substrate ascorbic acid 2-phosphate (AAP) can be enzymatically hydrolyzed to release ascorbic acid (AA), which in turn reduces Cu2+ to Cu+ ...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Hector J Rivera-Jacquez, Artëm E Masunov
Development of two-photon fluorescent probes can aid in visualizing the cellular environment. Multi-chromophore systems display complex manifolds of electronic transitions, enabling their use for optical sensing applications. Time-Dependent Density Functional Theory (TDDFT) methods allow for accurate predictions of the optical properties. These properties are related to the electronic transitions in the molecules, which include two-photon absorption cross-sections. Here we use TDDFT to understand the mechanism of aza-crown based fluorescent probes for metals sensing applications...
February 21, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Pallab Basuri, Depanjan Sarkar, Ganesan Paramasivam, Thalappil Pradeep
Here we introduce a new ambient ionization technique named as laser assisted paper spray ionization mass spectrometry (LAPSI MS). In it, a 532 ± 10 nm, ≤10 mW laser pointer was shone on a triangularly cut paper along with high voltage, to effect ionization. The analyte solution was continuously pushed through a fused silica capillary, using a syringe pump, at a preferred infusion rate. LAPSI MS promises enhanced ionization with high signal intensity of polycyclic aromatic hydrocarbons (PAHs), which are normally not ionizable with similar ionization methods involving solvent sprays...
March 9, 2018: Analytical Chemistry
Maria Cuartero, Gaston A Crespo, Thomas Cherubini, Nadezda Pankratova, Fabio Confalonieri, Francesco Massa, Mary-Lou Tercier-Waeber, Melina Abdou, Joerg Schaefer, Eric Bakker
A new submersible probe for the in situ detection of nitrate, nitrite and chloride in seawater is presented. Inline coupling of a desalination unit, an acidification unit and a sensing flow cell containing all-solid-state membrane electrodes allows for the potentiometric detection of nitrate and nitrite after removal of the key interfering ions in seawater, chloride and hydroxide. Thus, the electrodes exhibited attractive analytical performances for the potentiometric detection of nitrate and nitrite in desalinated and acidified seawater: fast response time (t95<12 s), excellent stability (long-term drifts of < 0...
March 8, 2018: Analytical Chemistry
Davide Bressanello, Erica Liberto, Massimo Collino, Fausto Chiazza, Raffaella Mastrocola, Stephen E Reichenbach, Carlo Bicchi, Chiara Cordero
This study exploits the information potential of comprehensive two-dimensional gas chromatography configured with a parallel dual secondary column-dual detection by mass spectrometry and flame ionization (GC×2GC-MS/FID) to study changes in urinary metabolic signatures of mice subjected to high-fructose diets. Samples are taken from mice fed with normal or fructose-enriched diets provided either in aqueous solution or in solid form and analyzed at three stages of the dietary intervention (1, 6, and 12 weeks)...
March 7, 2018: Analytical and Bioanalytical Chemistry
Yanli Ma, Yu Mao, Yuan An, Tian Tian, Huimin Zhang, Jinmao Yan, Zhi Zhu, Chaoyong James Yang
We have successfully developed a target-responsive aptamer cross-linked hydrogel for the visual detection of glucose, an important biomedical analyte. In this work, the glucose-responsive hydrogel was prepared using the target aptamer and its two short complementary DNA strands grafted onto a linear polyacrylamide chain as cross-linkers. Gold nanoparticles (AuNPs) modified with thiol-PEG were encapsulated in the gel and used as the output signal for visible detection. The complex of glucose and its ligand of boronic acid derivatives (Shinkai's receptor) can bind with the aptamer to disrupt the hydrogel, leading to the release of AuNPs with a distinct red colour in the supernatant...
March 7, 2018: Analyst
Federico Rotolo, Xavier Paoletti, Stefan Michiels
BACKGROUND AND OBJECTIVE: Surrogate endpoints are attractive for use in clinical trials instead of well-established endpoints because of practical convenience. To validate a surrogate endpoint, two important measures can be estimated in a meta-analytic context when individual patient data are available: the Rindiv 2 or the Kendall's τ at the individual level, and the Rtrial 2 at the trial level. We aimed at providing an R implementation of classical and well-established as well as more recent statistical methods for surrogacy assessment with failure time endpoints...
March 2018: Computer Methods and Programs in Biomedicine
Silvia Morbelli, Matteo Bauckneht
Amyloid plaques are a neuropathologic hallmark of Alzheimer's disease (AD), which can be imaged through positron emission tomography (PET) technology using radiopharmaceuticals that selectively bind to the fibrillar aggregates of amyloid-β plaques (Amy-PET). Several radiotracers for amyloid PET have been investigated, including11 C-Pittsburgh compound B and the18 F-labeled compounds such as18 F-florbetaben,18 F-florbetapir, and18 F-flutemetamol. Besides the injected radiotracer, images can be interpreted by means of visual/qualitative, semiquantitative, and quantitative criteria...
2018: Methods in Molecular Biology
Skylar W Marvel, Kimberly To, Fabian A Grimm, Fred A Wright, Ivan Rusyn, David M Reif
BACKGROUND: Drawing integrated conclusions from diverse source data requires synthesis across multiple types of information. The ToxPi (Toxicological Prioritization Index) is an analytical framework that was developed to enable integration of multiple sources of evidence by transforming data into integrated, visual profiles. Methodological improvements have advanced ToxPi and expanded its applicability, necessitating a new, consolidated software platform to provide functionality, while preserving flexibility for future updates...
March 5, 2018: BMC Bioinformatics
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