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https://www.readbyqxmd.com/read/27913147/electro-kinetically-driven-peristaltic-transport-of-viscoelastic-physiological-fluids-through-a-finite-length-capillary-mathematical-modelling
#1
Dharmendra Tripathi, Ashu Yadav, O Anwar BĂ©g
Analytical solutions are developed for the electro-kinetic flow of a viscoelastic biological liquid in a finite length cylindrical capillary geometry under peristaltic waves. The Jefferys' non-Newtonian constitutive model is employed to characterize rheological properties of the fluid. The unsteady conservation equations for mass and momentum with electro-kinetic and Darcian porous medium drag force terms are reduced to a system of steady linearized conservation equations in an axisymmetric coordinate system...
November 29, 2016: Mathematical Biosciences
https://www.readbyqxmd.com/read/27911484/platinum-complex-assemblies-as-luminescent-probes-and-tags-for-drugs-and-toxins-in-water
#2
Stephan Sinn, Frank Biedermann, Luisa De Cola
A reactive phosphorescent probe for aza-heterocyclic drugs and toxins was developed, affording a supramolecular emission-switch-on chemosensor in water. Complex formation of the heterocycles with a platinum(II) precursor proceeds readily at ambient conditions, allowing for facile analyte screening. 52 structurally diverse compounds were tested, out of which 23 pyridines, imidazole, and triazoles formed strongly emissive complex aggregates. Importantly, they all can be clearly distinguished from each other through a principal component analysis, but often already by simple visual inspection, e...
December 1, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27907142/ibisa_tools-a-computational-toolkit-for-ion-binding-state-analysis-in-molecular-dynamics-trajectories-of-ion-channels
#3
Kota Kasahara, Kengo Kinoshita
Ion conduction mechanisms of ion channels are a long-standing conundrum. Although the molecular dynamics (MD) method has been extensively used to simulate ion conduction dynamics at the atomic level, analysis and interpretation of MD results are not straightforward due to complexity of the dynamics. In our previous reports, we proposed an analytical method called ion-binding state analysis to scrutinize and summarize ion conduction mechanisms by taking advantage of a variety of analytical protocols, e.g., the complex network analysis, sequence alignment, and hierarchical clustering...
2016: PloS One
https://www.readbyqxmd.com/read/27899596/chitars-3-1-the-enhanced-chimeric-transcripts-and-rna-seq-database-matched-with-protein-protein-interactions
#4
Alessandro Gorohovski, Somnath Tagore, Vikrant Palande, Assaf Malka, Dorith Raviv-Shay, Milana Frenkel-Morgenstern
Discovery of chimeric RNAs, which are produced by chromosomal translocations as well as the joining of exons from different genes by trans-splicing, has added a new level of complexity to our study and understanding of the transcriptome. The enhanced ChiTaRS-3.1 database (http://chitars.md.biu.ac.il) is designed to make widely accessible a wealth of mined data on chimeric RNAs, with easy-to-use analytical tools built-in. The database comprises 34 922: chimeric transcripts along with 11 714: cancer breakpoints...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898834/the-triticeae-toolbox-combining-phenotype-and-genotype-data-to-advance-small-grains-breeding
#5
Victoria C Blake, Clay Birkett, David E Matthews, David L Hane, Peter Bradbury, Jean-Luc Jannink
The Triticeae Toolbox (; T3) is the database schema enabling plant breeders and researchers to combine, visualize, and interrogate the wealth of phenotype and genotype data generated by the Triticeae Coordinated Agricultural Project (TCAP). T3 enables users to define specific data sets for download in formats compatible with the external tools TASSEL, Flapjack, and R; or to use by software residing on the T3 server for operations such as Genome Wide Association and Genomic Prediction. New T3 tools to assist plant breeders include a Selection Index Generator, analytical tools to compare phenotype trials using common or user-defined indices, and a histogram generator for nursery reports, with applications using the Android OS, and a Field Plot Layout Designer in development...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27894861/development-of-a-competitive-double-antibody-lateral-flow-assay-for-the-detection-of-antibodies-specific-to-glycoprotein-b-of-aujeszky-s-disease-virus-in-swine-sera
#6
V V Vrublevskaya, V N Afanasyev, A A Grinevich, Yu Y Skarga, P P Gladyshev, S A Ibragimova, D V Krylsky, O S Morenkov
Three lateral flow assays (LFAs) for the detection of antibodies against glycoprotein B (gB) of Aujeszky's disease virus (ADV) in swine sera: a competitive double antibody sandwich LFA without a preincubation step (CDAS-gB-LFA), a CDAS-gB-LFA with a preincubation step (pCDAS-gB-LFA), and a competitive direct gB-LFA have been developed and were compared with each other and with a gB-ELISA. The assays are based on monoclonal antibodies to immunodominant epitopes of ADV gB. The pCDAS-gB-LFA proved to be the most specific and sensitive assay to detect antibodies directed to ADV gB...
November 25, 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27893368/bkviz-a-basketball-visual-analysis-tool
#7
Antonio G Losada, Roberto Theron, Alejandro Benito
The amount of data available in the sports field is difficult for coaches, analysts, and players to comprehend using classic analytics methods. Thus, new methods are necessary to help users break down that information and analyze it at a deeper level. The BKViz visual analytics system focuses on individual basketball games using classic and novel methods to reveal how players perform together and as individuals. The information is presented in interactive visualizations that allow immediate user feedback.
November 2016: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/27893063/assessment-of-the-psychometric-properties-of-a-questionnaire-assessing-patient-reported-outcomes-with-laser-in-situ-keratomileusis-prowl
#8
Ron D Hays, Michelle E Tarver, Karen L Spritzer, Steve Reise, Gene Hilmantel, Elizabeth M Hofmeister, Keri Hammel, Jeanine May, Frederick Ferris, Malvina Eydelman
Importance: Patient-reported outcome (PRO) measures for laser in situ keratomileusis (LASIK) are needed. Objective: To develop PRO measures to assess satisfaction, eye-related symptoms, and their effect on functioning and well-being following LASIK based on patient and expert input. Design, Setting, and Participants: The Patient-Reported Outcomes With LASIK (PROWL) studies were prospective observational studies of patients undergoing LASIK surgery for myopia, hyperopia, or astigmatism...
November 23, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27884254/troponin-testing-for-clinicians
#9
REVIEW
John E Brush, Sanjay Kaul, Harlan M Krumholz
The analytical performance of troponin assays has improved markedly in the last 2 decades. The variety of assays, their evolution over time, and their critical importance in influencing care, mandates the need for skills in their use. There are 3 critical elements necessary for optimal use of troponin testing in clinical care, as follows: 1) the analytical performance of the assay; 2) the clinical sensitivity and specificity of the test result; and 3) the clinical reasoning for ordering and the proper clinical context for interpreting the test result...
November 29, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27884135/online-platform-for-applying-space-time-scan-statistics-for-prospectively-detecting-emerging-hot-spots-of-dengue-fever
#10
Chien-Chou Chen, Yung-Chu Teng, Bo-Cheng Lin, I-Chun Fan, Ta-Chien Chan
BACKGROUND: Cases of dengue fever have increased in areas of Southeast Asia in recent years. Taiwan hit a record-high 42,856 cases in 2015, with the majority in southern Tainan and Kaohsiung Cities. Leveraging spatial statistics and geo-visualization techniques, we aim to design an online analytical tool for local public health workers to prospectively identify ongoing hot spots of dengue fever weekly at the village level. METHODS: A total of 57,516 confirmed cases of dengue fever in 2014 and 2015 were obtained from the Taiwan Centers for Disease Control (TCDC)...
November 25, 2016: International Journal of Health Geographics
https://www.readbyqxmd.com/read/27882571/a-note-on-statistical-repeatability-and-study-design-for-high-throughput-assays
#11
George Nicholson, Chris Holmes
Characterizing the technical precision of measurements is a necessary stage in the planning of experiments and in the formal sample size calculation for optimal design. Instruments that measure multiple analytes simultaneously, such as in high-throughput assays arising in biomedical research, pose particular challenges from a statistical perspective. The current most popular method for assessing precision of high-throughput assays is by scatterplotting data from technical replicates. Here, we question the statistical rationale of this approach from both an empirical and theoretical perspective, illustrating our discussion using four example data sets from different genomic platforms...
November 24, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27878106/multiparameter-evaluation-of-the-heterogeneity-of-circulating-tumor-cells-using-integrated-rna-in-situ-hybridization-and-immunocytochemical-analysis
#12
Yongqi Wu, Kyoung-Joo Jenny Park, Clayton Deighan, Peter Amaya, Brandon Miller, Quintin Pan, Maciej Zborowski, Maryam Lustberg, Jeffery Chalmers
Circulating tumor cells (CTCs) are routinely identified as cytokeratin (CK)-positive, epithelial cell adhesion molecule (EpCAM)-positive, and CD45-negative and are enriched based on EpCAM. However, there are a number of methodological challenges regarding both isolation and characterization of these rare CTCs including downregulation or absence of EpCAM in a variety of solid tumors leading to the omission of subpopulations of CTCs, difficulties in analyzing RNA and protein targets in CTCs due to the rarity of these cells, and low levels of targets and technological limitations of visualizing the targets of interest on each individual cell...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27875189/corresponding-supine-and-prone-colon-visualization-using-eigenfunction-analysis-and-fold-modeling
#13
Saad Nadeem, Joseph Marino, Xianfeng Gu, Arie Kaufman
We present a method for registration and visualization of corresponding supine and prone virtual colonoscopy scans based on eigenfunction analysis and fold modeling. In virtual colonoscopy, CT scans are acquired with the patient in two positions, and their registration is desirable so that physicians can corroborate findings between scans. Our algorithm performs this registration efficiently through the use of Fiedler vector representation (the second eigenfunction of the Laplace-Beltrami operator). This representation is employed to first perform global registration of the two colon positions...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27875171/vlat-development-of-a-visualization-literacy-assessment-test
#14
Sukwon Lee, Sung-Hee Kim, Bum Chul Kwon
The Information Visualization community has begun to pay attention to visualization literacy; however, researchers still lack instruments for measuring the visualization literacy of users. In order to address this gap, we systematically developed a visualization literacy assessment test (VLAT), especially for non-expert users in data visualization, by following the established procedure of test development in Psychological and Educational Measurement: (1) Test Blueprint Construction, (2) Test Item Generation, (3) Content Validity Evaluation, (4) Test Tryout and Item Analysis, (5) Test Item Selection, and (6) Reliability Evaluation...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27875155/map-lineups-effects-of-spatial-structure-on-graphical-inference
#15
Roger Beecham, Jason Dykes, Wouter Meulemans, Aidan Slingsby, Cagatay Turkay, Jo Wood
Fundamental to the effective use of visualization as an analytic and descriptive tool is the assurance that presenting data visually provides the capability of making inferences from what we see. This paper explores two related approaches to quantifying the confidence we may have in making visual inferences from mapped geospatial data. We adapt Wickham et al.'s 'Visual Line-up' method as a direct analogy with Null Hypothesis Significance Testing (NHST) and propose a new approach for generating more credible spatial null hypotheses...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27875148/patterns-and-sequences-interactive-exploration-of-clickstreams-to-understand-common-visitor-paths
#16
Zhicheng Liu, Yang Wang, Mira Dontcheva, Matthew Hoffman, Seth Walker, Alan Wilson
Modern web clickstream data consists of long, high-dimensional sequences of multivariate events, making it difficult to analyze. Following the overarching principle that the visual interface should provide information about the dataset at multiple levels of granularity and allow users to easily navigate across these levels, we identify four levels of granularity in clickstream analysis: patterns, segments, sequences and events. We present an analytic pipeline consisting of three stages: pattern mining, pattern pruning and coordinated exploration between patterns and sequences...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27875147/gazedx-interactive-visual-analytics-framework-for-comparative-gaze-analysis-with-volumetric-medical-images
#17
Hyunjoo Song, Jeongjin Lee, Tae Jung Kim, Kyoung Ho Lee, Bohyoung Kim, Jinwook Seo
We present an interactive visual analytics framework, GazeDx (abbr. of GazeDiagnosis), for the comparative analysis of gaze data from multiple readers examining volumetric images while integrating important contextual information with the gaze data. Gaze pattern comparison is essential to understanding how radiologists examine medical images, and to identifying factors influencing the examination. Most prior work depended upon comparisons with manually juxtaposed static images of gaze tracking results. Comparative gaze analysis with volumetric images is more challenging due to the additional cognitive load on 3D perception...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27875146/visual-analytics-for-mobile-eye-tracking
#18
Kuno Kurzhals, Marcel Hlawatsch, Christof Seeger, Daniel Weiskopf
The analysis of eye tracking data often requires the annotation of areas of interest (AOIs) to derive semantic interpretations of human viewing behavior during experiments. This annotation is typically the most time-consuming step of the analysis process. Especially for data from wearable eye tracking glasses, every independently recorded video has to be annotated individually and corresponding AOIs between videos have to be identified. We provide a novel visual analytics approach to ease this annotation process by image-based, automatic clustering of eye tracking data integrated in an interactive labeling and analysis system...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27875145/vidx-visual-diagnostics-of-assembly-line-performance-in-smart-factories
#19
Panpan Xu, Honghui Mei, Liu Ren, Wei Chen
Visual analytics plays a key role in the era of connected industry (or industry 4.0, industrial internet) as modern machines and assembly lines generate large amounts of data and effective visual exploration techniques are needed for troubleshooting, process optimization, and decision making. However, developing effective visual analytics solutions for this application domain is a challenging task due to the sheer volume and the complexity of the data collected in the manufacturing processes. We report the design and implementation of a comprehensive visual analytics system, ViDX...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27875144/what-do-constraint-programming-users-want-to-see-exploring-the-role-of-visualisation-in-profiling-of-models-and-search
#20
Sarah Goodwin, Christopher Mears, Tim Dwyer, Maria Garcia de la Banda, Guido Tack, Mark Wallace
Constraint programming allows difficult combinatorial problems to be modelled declaratively and solved automatically. Advances in solver technologies over recent years have allowed the successful use of constraint programming in many application areas. However, when a particular solver's search for a solution takes too long, the complexity of the constraint program execution hinders the programmer's ability to profile that search and understand how it relates to their model. Therefore, effective tools to support such profiling and allow users of constraint programming technologies to refine their model or experiment with different search parameters are essential...
January 2017: IEEE Transactions on Visualization and Computer Graphics
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