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https://www.readbyqxmd.com/read/28551109/early-visual-analysis-tool-using-magnetoencephalography-for-treatment-and-recovery-of-neuronal-dysfunction
#1
Waqas Rasheed, Yee Yik Neoh, Nor Hisham Bin Hamid, Faruque Reza, Zamzuri Idris, Tong Boon Tang
Functional neuroimaging modalities play an important role in deciding the diagnosis and course of treatment of neuronal dysfunction and degeneration. This article presents an analytical tool with visualization by exploiting the strengths of the MEG (magnetoencephalographic) neuroimaging technique. The tool automates MEG data import (in tSSS format), channel information extraction, time/frequency decomposition, and circular graph visualization (connectogram) for simple result inspection. For advanced users, the tool also provides magnitude squared coherence (MSC) values allowing personalized threshold levels, and the computation of default model from MEG data of control population...
May 11, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28549568/using-visual-analytics-for-presenting-comparative-information-on-new-drugs
#2
Jean-Baptiste Lamy, Hélène Berthelot, Madeleine Favre, Adrien Ugon, Catherine Duclos, Alain Venot
OBJECTIVE: When a new drug is marketed, physicians must decide whether they will consider it for their future practice. However, information about new drugs can be biased or hard to find. In this work, our objective was to study whether visual analytics could be used for comparing drug properties such as contraindications and adverse effects, and whether this visual comparison can help physicians to forge their own well-founded opinions about a new drug. MATERIALS AND METHODS: First, an ontology for comparative drug information was designed, based on the expectations expressed during focus groups comprised of physicians...
May 23, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28548572/analytical-validation-of-a-reference-laboratory-elisa-for-the-detection-of-feline-leukemia-virus-p27-antigen
#3
Jesse S Buch, Genevieve H Clark, Roberta Cahill, Brendon Thatcher, Peter Smith, Ramaswamy Chandrashekar, Christian M Leutenegger, Thomas P O'Connor, Melissa J Beall
Feline leukemia virus (FeLV) is an oncogenic retrovirus of cats. Immunoassays for the p27 core protein of FeLV aid in the detection of FeLV infections. Commercial microtiter-plate ELISAs have rapid protocols and visual result interpretation, limiting their usefulness in high-throughput situations. The purpose of our study was to validate the PetChek FeLV 15 ELISA, which is designed for the reference laboratory, and incorporates sequential, orthogonal screening and confirmatory protocols. A cutoff for the screening assay was established with 100% accuracy using 309 feline samples (244 negative, 65 positive) defined by the combined results of FeLV PCR and an independent reference p27 antigen ELISA...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28545439/distribution-of-white-spot-lesions-among-orthodontic-patients-attending-teaching-institutes-in-khartoum
#4
Maha Kamal Eltayeb, Yahia Eltayeb Ibrahim, Ikhlas Ali El Karim, Nada Mirghani Sanhouri
BACKGROUND: Fixed orthodontic appliances render teeth cleaning arduous, thus when orthodontic treatment is associated with inadequate oral hygiene practice, development of white spot lesions (WSLs) imposes a significant risk on the dentition. Salivary reservoir of calcium, magnesium, phosphorous and fluoride counteracts demineralization and encourages remineralization providing protection against caries challenge. The investigation of the factors leading to WSLs' development is mandatory for appropriate prevention strategies planning...
May 25, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28541518/mapping-healthcare-systems-a-policy-relevant-analytic-tool
#5
Neelam Sekhri Feachem, Ariana Afshar, Cristina Pruett, Anton L V Avanceña
Background: In the past decade, an international consensus on the value of well-functioning systems has driven considerable health systems research. This research falls into two broad categories. The first provides conceptual frameworks that take complex healthcare systems and create simplified constructs of interactions and functions. The second focuses on granular inputs and outputs. This paper presents a novel translational mapping tool - the University of California, San Francisco mapping tool (the Tool) - which bridges the gap between these two areas of research, creating a platform for multi-country comparative analysis...
May 25, 2017: International Health
https://www.readbyqxmd.com/read/28541377/asap-a-web-based-platform-for-the-analysis-and-interactive-visualization-of-single-cell-rna-seq-data
#6
Vincent Gardeux, Fabrice P A David, Adrian Shajkofci, Petra C Schwalie, Bart Deplancke
Motivation: Single-cell RNA-sequencing (scRNA-seq) allows whole transcriptome profiling of thousands of individual cells, enabling the molecular exploration of tissues at the cellular level. Such analytical capacity is of great interest to many research groups in the world, yet these groups often lack the expertise to handle complex scRNA-seq data sets. Results: We developed a fully integrated, web-based platform aimed at the complete analysis of scRNA-seq data post genome alignment: from the parsing, filtering, and normalization of the input count data files, to the visual representation of the data, identification of cell clusters, differentially expressed genes (including cluster-specific marker genes), and functional gene set enrichment...
May 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28537380/a-dna-tetrahedron-nanoprobe-with-controlled-distance-of-dyes-for-multiple-detection-in-living-cells-and-in-vivo
#7
Na Li, Meimei Wang, Xiaonan Gao, Zhengze Yu, Wei Pan, Hongyu Wang, Bo Tang
Multicomponent quantitative detection in living samples is becoming increasingly important, however, the current detection strategy may cause fluorescence self-quenching and reduce the sensitivity of detection. To solve the problem, we develop a DNA tetrahedral nanoprobe to control the dyes distance for simultaneous detection of multiple analytes. Compared to mesoporous silica nanoparticles based nanoprobes, the DNA tetrahedral nanoprobes display enhanced fluorescence intensities due to partially avoiding the fluorescence resonance energy transfer...
May 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28532387/robust-estimation-of-the-expected-survival-probabilities-from-high-dimensional-cox-models-with-biomarker-by-treatment-interactions-in-randomized-clinical-trials
#8
Nils Ternès, Federico Rotolo, Stefan Michiels
BACKGROUND: Thanks to the advances in genomics and targeted treatments, more and more prediction models based on biomarkers are being developed to predict potential benefit from treatments in a randomized clinical trial. Despite the methodological framework for the development and validation of prediction models in a high-dimensional setting is getting more and more established, no clear guidance exists yet on how to estimate expected survival probabilities in a penalized model with biomarker-by-treatment interactions...
May 22, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28529698/seven-perspectives-on-gpcr-h-d-exchange-proteomics-methods
#9
Xi Zhang
Recent research shows surging interest to visualize human G protein-coupled receptor (GPCR) dynamic structures using the bottom-up H/D-exchange (HDX) proteomics technology. This opinion article clarifies critical technical nuances and logical thinking behind the GPCR HDX proteomics method, to help scientists overcome cross-discipline pitfalls, and understand and reproduce the protocol at high quality. The 2010 89% HDX structural coverage of GPCR was achieved with both structural and analytical rigor. This article emphasizes systematically considering membrane protein structure stability and compatibility with chromatography and mass spectrometry (MS) throughout the pipeline, including the effects of metal ions, zero-detergent shock, and freeze-thaws on HDX result rigor...
2017: F1000Research
https://www.readbyqxmd.com/read/28528487/role-of-medicines-of-unknown-identity-in-adverse-drug-reaction-related-hospitalizations-in-developing-countries-evidence-from-a-cross-sectional-study-in-a-teaching-hospital-in-the-lao-people-s-democratic-republic
#10
Céline Caillet, Chanvilay Sichanh, Gaëtan Assemat, Myriam Malet-Martino, Agnès Sommet, Haleh Bagheri, Noudy Sengxeu, Niphonh Mongkhonmath, Mayfong Mayxay, Lamphone Syhakhang, Maryse Lapeyre-Mestre, Paul N Newton, Anne Roussin
INTRODUCTION: The health dangers of medicines of unknown identity (MUIs) [loose pharmaceutical units repackaged in individual bags without labelling of their identity] have been suspected in L/MICs. Using visual and analytical tools to identify MUIs, we investigated the frequency of, and factors associated with, adverse drug reaction (ADR)-related hospitalizations in a central hospital in Vientiane Capital, Lao People's Democratic Republic (PDR). METHODS: All unplanned admissions, except for acute trauma and intentional overdose, were prospectively recorded during a 7-week period in 2013, leading to include 453 adults hospitalized for ≥24 h...
May 20, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28527785/the-effectiveness-of-a-fixed-dose-combination-pour-on-formulation-of-1-25-fipronil-and-2-5-fluazuron-against-economically-important-ectoparasites-and-associated-pharmacokinetics-in-cattle
#11
Welber Daniel Zanetti Lopes, Rafael Marin Chiummo, Luis Fernando Vettorato, Daniel de Castro Rodrigues, Rafael Bazaglia Sonada
The present work consisted of eight studies to evaluate the ectoparasiticidal spectrum and determine the pharmacokinetic parameters of a pour-on combination of fipronil 1.25mg/kg+fluazuron 2.5mg/kg for cattle against Rhipicephalus microplus, Haematobia irritans and the larvae of Dermatobia hominis and Cochliomyia hominivorax. The analysis fipronil and fluazuron were performed by liquid chromatography using a mass detector for the detection and quantification of analytes (LC-MS/MS). Additionally, in two of these studies, the animals were artificially infested with R...
May 17, 2017: Parasitology International
https://www.readbyqxmd.com/read/28521939/developmental-and-evolutionary-mechanisms-shaping-butterfly-eyespots
#12
REVIEW
Patrícia Beldade, Carolina M Peralta
Butterfly eyespots are visually compelling models to study the reciprocal interactions between evolutionary and developmental processes that shape phenotypic variation. They are evolutionarily diversified, ecologically relevant, and developmentally tractable, and have made key contributions to linking genotype, development, phenotype and fitness. Advances in the availability of analytical tools (e.g. gene editing and visualization techniques) and resources (e.g. genomic and transcriptomic data) are boosting the detailed dissection of the mechanisms underlying eyespot development and evolution...
February 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28518075/leveraging-cyverse-resources-for-de-novo-comparative-transcriptomics-of-underserved-non-model-organisms
#13
Blake L Joyce, Asher K Haug-Baltzell, Jonathan P Hulvey, Fiona McCarthy, Upendra Kumar Devisetty, Eric Lyons
This workflow allows novice researchers to leverage advanced computational resources such as cloud computing to carry out pairwise comparative transcriptomics. It also serves as a primer for biologists to develop data scientist computational skills, e.g. executing bash commands, visualization and management of large data sets. All command line code and further explanations of each command or step can be found on the wiki (https://wiki.cyverse.org/wiki/x/dgGtAQ). The Discovery Environment and Atmosphere platforms are connected together through the CyVerse Data Store...
May 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28511008/cascade-reaction-based-near-infrared-multiphoton-fluorescent-probe-for-the-selective-detection-of-cysteine
#14
Rasika R Nawimanage, Bijeta Prasai, Suraj U Hettiarachchi, Robin L McCarley
The ability to detect and visualize cellular events and their associated target biological analytes through use of cell-permeable profluorogenic probes is dependent on the availability of activatable probes that respond rapidly and selectively to target analytes by production of fluorescent reporting molecules whose excitation and emission energies span a broad range. Herein is described a new probe, DCM-Cys, that preferentially reacts with cysteine to form a dicyanomethylene-4H-pyran (DCM) reporter whose red-energy fluorescence can be stimulated by two-photon, near-infrared excitation so as to provide visualization of cysteine presence inside living human cells with a high signal-to-background ratio...
May 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28510753/a-different-use-of-visual-analytic-techniques-in-anaesthetics
#15
R Rice, I Rice
No abstract text is available yet for this article.
May 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28510334/angiogenesis-within-stem-cell-seeded-silk-scaffolds-cultured-on-the-chorioallantoic-membrane-and-visualized-by-3d-imaging
#16
Anna Woloszyk, Thimios A Mitsiadis
The long-term survival and successful integration of implants for tissue replacement and regeneration highly depends upon the fast ingrowth of blood vessels from the surrounding tissues. Before selecting potential biomaterials for clinical applications, they must be thoroughly tested with proper analytical tools. This unit provides a protocol for studying the potential of cell-seeded scaffolds to attract vessels that will form vascular networks within biomaterials. It includes seeding of stem cells into silk fibroin scaffolds, angiogenesis assay on the chorioallantoic membrane (CAM) of fertilized chicken eggs, a procedure for perfusion with MicroFil, and finally microcomputed tomography (µCT) scanning...
May 16, 2017: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/28508375/an-integration-of-decision-tree-and-visual-analysis-to-analyze-intracranial-pressure
#17
Soo-Yeon Ji, Kayvan Najarian, Toan Huynh, Dong Hyun Jeong
In Traumatic Brain Injury (TBI), elevated Intracranial Pressure (ICP) causes severe brain damages due to hemorrhage and swelling. Monitoring ICP plays an important role in the treatment of TBI patients because ICP is considered a strong predictor of neurological outcome and a potentially amenable method to treat patients. However, it is difficult to predict and measure accurate ICP due to the complex nature of patients' clinical conditions. ICP monitoring for severe TBI patient is a challenging problem for clinicians because traditionally known ICP monitoring is an invasive procedure by placing a device inside the brain to measure pressure...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28508373/an-advanced-omic-approach-to-identify-co-regulated-clusters-and-transcription-regulation-network-with-agct-and-shoe-methods
#18
Natalia Polouliakh, Richard Nock
To obtain the global picture of genetic machinery for massive high-throughput gene expression data, novel data-driven unsupervised learning approaches are becoming essentially important. For this purpose, basic analytic workflow has been established and should include two steps: first, unsupervised clustering to identify genes with similar behavior upon exposure to a signal, and second, identification of transcription factors regulating those genes. In this chapter, we will describe an advanced tool that can be used for analyzing and characterizing large-scale time-series gene expression composed of a two-step approach...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28506288/visualizing-statistical-significance-of-disease-clusters-using-cartograms
#19
Barry J Kronenfeld, David W S Wong
BACKGROUND: Health officials and epidemiological researchers often use maps of disease rates to identify potential disease clusters. Because these maps exaggerate the prominence of low-density districts and hide potential clusters in urban (high-density) areas, many researchers have used density-equalizing maps (cartograms) as a basis for epidemiological mapping. However, we do not have existing guidelines for visual assessment of statistical uncertainty. To address this shortcoming, we develop techniques for visual determination of statistical significance of clusters spanning one or more districts on a cartogram...
May 15, 2017: International Journal of Health Geographics
https://www.readbyqxmd.com/read/28506234/anti-malarial-medicine-quality-field-studies-and-surveys-a-systematic-review-of-screening-technologies-used-and-reporting-of-findings
#20
REVIEW
Mirza Lalani, Freddy Eric Kitutu, Siân E Clarke, Harparkash Kaur
BACKGROUND: Assessing the quality of medicines in low-middle income countries (LMICs) relies primarily on human inspection and screening technologies, where available. Field studies and surveys have frequently utilized screening tests to analyse medicines sampled at the point of care, such as health care facilities and medicine outlets, to provide a snap shot of medicine quality in a specific geographical area. This review presents an overview of the screening tests typically employed in surveys to assess anti-malarial medicine quality, summarizes the analytical methods used, how findings have been reported and proposes a reporting template for future studies...
May 15, 2017: Malaria Journal
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