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https://www.readbyqxmd.com/read/29149211/occupational-exposure-to-unburnt-tobacco-and-potential-risk-of-toxic-optic-neuropathy-a-cross-sectional-study-among-beedi-rollers-in-selected-rural-areas-of-coastal-karnataka-india
#1
Soujanya Kaup, Ansaba Naseer, Siddharudha Shivalli, Cynthia Arunachalam
BACKGROUND: Beedi also known as poor man's cigarette is manufactured in almost all major states of India. Beedi workers are exposed to various health risks. There is an increased risk of systemic absorption of tobacco through skin and mucous membrane. The optic nerve is susceptible to damage from several toxic substances including tobacco. This group of disorders is known as toxic optic neuropathy (TON). The association of TON with occupational exposure to unburnt tobacco in beedi rollers has not been explored...
2017: PloS One
https://www.readbyqxmd.com/read/29148710/lipidqc-method-validation-tool-for-visual-comparison-to-srm-1950-using-nist-interlaboratory-comparison-exercise-lipid-consensus-mean-estimate-values
#2
Candice Zena Ulmer, Jared M Ragland, Jeremy P Koelmel, Alan Heckert, Christina M Jones, Timothy Garrett, Richard A Yost, John A Bowden
As advances in analytical separation techniques, mass spectrometry instrumentation, and data processing platforms continue to spur growth in the lipidomics field, more structurally unique lipid species are detected and annotated. The lipidomics community is in need of benchmark reference values to assess the validity of various lipidomics workflows in providing accurate quantitative measurements across the diverse lipidome. LipidQC addresses the harmonization challenge in lipid quantitation by providing a semi-automated process, independent of analytical platform, for visual comparison of experimental results of National Institute of Standards and Technology Standard Reference Material (SRM) 1950 Metabolites in Frozen Human Plasma against benchmark consensus mean concentrations derived from the NIST Lipidomics Interlaboratory Comparison Exercise...
November 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29145823/dbmdega-a-database-for-meta-analysis-of-differentially-expressed-genes-in-autism-spectrum-disorder
#3
Shuyun Zhang, Libin Deng, Qiyue Jia, Shaoting Huang, Junwang Gu, Fankun Zhou, Meng Gao, Xinyi Sun, Chang Feng, Guangqin Fan
BACKGROUND: Autism spectrum disorders (ASD) are hereditary, heterogeneous and biologically complex neurodevelopmental disorders. Individual studies on gene expression in ASD cannot provide clear consensus conclusions. Therefore, a systematic review to synthesize the current findings from brain tissues and a search tool to share the meta-analysis results are urgently needed. METHODS: Here, we conducted a meta-analysis of brain gene expression profiles in the current reported human ASD expression datasets (with 84 frozen male cortex samples, 17 female cortex samples, 32 cerebellum samples and 4 formalin fixed samples) and knock-out mouse ASD model expression datasets (with 80 collective brain samples)...
November 16, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29139050/modeling-mesoscopic-cortical-dynamics-using-a-mean-field-model-of-conductance-based-networks-of-adaptive-exponential-integrate-and-fire-neurons
#4
Yann Zerlaut, Sandrine Chemla, Frederic Chavane, Alain Destexhe
Voltage-sensitive dye imaging (VSDi) has revealed fundamental properties of neocortical processing at macroscopic scales. Since for each pixel VSDi signals report the average membrane potential over hundreds of neurons, it seems natural to use a mean-field formalism to model such signals. Here, we present a mean-field model of networks of Adaptive Exponential (AdEx) integrate-and-fire neurons, with conductance-based synaptic interactions. We study a network of regular-spiking (RS) excitatory neurons and fast-spiking (FS) inhibitory neurons...
November 15, 2017: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29138477/the-exact-curve-equation-for-majorana-stars
#5
Fei Yao, Dechao Li, Haodi Liu, Libin Fu, Xiaoguang Wang
Majorana stars are visual representation for a quantum pure state. For some states, the corresponding majorana stars are located on one curve on the Block sphere. However, it is lack of exact curve equations for them. To find the exact equations, we consider a superposition of two bosonic coherent states with an arbitrary relative phase. We analytically give the curve equation and find that the curve always goes through the North pole on the Block sphere. Furthermore, for the superpositions of SU(1,1) coherent states, we find the same curve equation...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29136799/ratiometric-fluorescence-and-visual-imaging-detection-of-dopamine-based-on-carbon-dots-copper-nanoclusters-dual-emitting-nanohybrids
#6
Weijie He, Rijun Gui, Hui Jin, Benqian Wang, Xiangning Bu, Yongxin Fu
In this article, blue-emitting carbon dots (CDs) were prepared via hydrothermal treatment of sodium citrate and NH4HCO3, and then combined with 3-aminophenylboronic acid (APBA) to prepare APBA modified-CDs. APBA acted as the receptor of dopamine (DA). Using bovine serum albumin (BSA) as a stabilizer and N2H4·H2O as a reducing reagent, BSA-stabilized and red-emitting copper nanoclusters (CuNCs) were prepared. By carbodiimide-activated coupling, novel nanohybrids consisting of CDs and CuNCs were constructed and exhibited dual-emitting fluorescence (FL)...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29132047/in-situ-label-free-monitoring-of-human-adipose-derived-mesenchymal-stem-cell-differentiation-into-multiple-lineages
#7
Intan Rosalina Suhito, Yoojoong Han, Junhong Min, Hyungbin Son, Tae-Hyung Kim
Precise characterizations of stem cell differentiation into specific lineages, especially in non-destructive and non-invasive manner, are extremely important for generating patient-specific cells without mass loss of differentiated cells. Here, we report a new method capable of in situ label-free quantification of stem cell differentiation into multiple lineages, even at a single cell level. The human adipose-derived mesenchymal stem cells (hADMSCs) were first differentiated into two different types of cells (osteoblasts and adipocytes) and these differentiated cells were then intensively analyzed by micro-Raman spectroscopy...
November 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/29131592/a-paper-plastic-hybrid-microfluidic-device-for-smartphone-based-colorimetric-analysis-of-urine
#8
M Jalal Uddin, Gyeong Jun Jin, Joon Sub Shim
In this work, a disposable paper-plastic hybrid microfluidic lab-on-a-chip (LOC) has been developed and successfully applied for the colorimetric measurement of urine by the smartphone-based optical platform using an "UrineAnalysis" Android app. The developed device was cost-effectively implemented as a stand-alone hybrid LOC by incorporating the paper-based conventional reagent test strip inside the plastic-based LOC microchannel. The LOC device quantitatively investigated the small volume (40 µL) of urine analytes for the colorimetric reaction of glucose, protein, pH and red blood cell (RBC) in integration with the finger-actuating micro pump...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29126249/the-encyclopedia-of-dna-elements-encode-data-portal-update
#9
Carrie A Davis, Benjamin C Hitz, Cricket A Sloan, Esther T Chan, Jean M Davidson, Idan Gabdank, Jason A Hilton, Kriti Jain, Ulugbek K Baymuradov, Aditi K Narayanan, Kathrina C Onate, Keenan Graham, Stuart R Miyasato, Timothy R Dreszer, J Seth Strattan, Otto Jolanki, Forrest Y Tanaka, J Michael Cherry
The Encyclopedia of DNA Elements (ENCODE) Data Coordinating Center has developed the ENCODE Portal database and website as the source for the data and metadata generated by the ENCODE Consortium. Two principles have motivated the design. First, experimental protocols, analytical procedures and the data themselves should be made publicly accessible through a coherent, web-based search and download interface. Second, the same interface should serve carefully curated metadata that record the provenance of the data and justify its interpretation in biological terms...
November 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29125535/an-intelligent-cooperative-visual-sensor-network-for-urban-mobility
#10
Giuseppe Riccardo Leone, Davide Moroni, Gabriele Pieri, Matteo Petracca, Ovidio Salvetti, Andrea Azzarà, Francesco Marino
Smart cities are demanding solutions for improved traffic efficiency, in order to guarantee optimal access to mobility resources available in urban areas. Intelligent video analytics deployed directly on board embedded sensors offers great opportunities to gather highly informative data about traffic and transport, allowing reconstruction of a real-time neat picture of urban mobility patterns. In this paper, we present a visual sensor network in which each node embeds computer vision logics for analyzing in real time urban traffic...
November 10, 2017: Sensors
https://www.readbyqxmd.com/read/29120648/the-role-of-nanoparticle-design-in-determining-analytical-performance-of-lateral-flow-immunoassays
#11
Li Zhan, Shuang-Zhuang Guo, Fayi Song, Yan Gong, Feng Xu, David R Boulware, Michael C McAlpine, Warren C W Chan, John C Bischof
Rapid, simple, and cost-effective diagnostics are needed to improve healthcare at the point of care (POC). However, the most widely used POC diagnostic, the lateral flow immunoassay (LFA), is ∼1000-times less sensitive and has a smaller analytical range than laboratory tests, requiring a confirmatory test to establish truly negative results. Here, a rational and systematic strategy is used to design the LFA contrast label (i.e., gold nanoparticles) to improve the analytical sensitivity, analytical detection range, and antigen quantification of LFAs...
November 15, 2017: Nano Letters
https://www.readbyqxmd.com/read/29120601/light-responsive-silk-nanofibers-an-optochemical-platform-for-environmental-applications
#12
Maria E Genovese, Gianvito Caputo, Gabriele Nanni, Chiara Setti, Matteo Bustreo, Giovanni Perotto, Athanassia Athanassiou, Despina Fragouli
Photochromic spiropyran-doped silk fibroin poly(ethylene oxide) nanofibers which combine the attractive properties and biocompatibility of silk with the photocontrollable and reversible optical, mechanical, and chemical response of the spiropyran dopants are herein presented. As proved, the reversible variation of the absorption and emission signals of the mats and of their Young's modulus upon alternate UV and visible light irradiation is ascribed to the reversible photoconversion of the spiropyran form to its polar merocyanine counterpart...
November 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29117744/twelve-tips-to-promote-successful-development-of-a-learner-performance-dashboard-within-a-medical-education-program
#13
Christy Boscardin, Kirkpatrick B Fergus, Bonnie Hellevig, Karen E Hauer
Easily accessible and interpretable performance data constitute critical feedback for learners that facilitate informed self-assessment and learning planning. To provide this feedback, there has been a proliferation of educational dashboards in recent years. An educational (learner) dashboard systematically delivers timely and continuous feedback on performance and can provide easily visualized and interpreted performance data. In this paper, we provide practical tips for developing a functional, user-friendly individual learner performance dashboard and literature review of dashboard development, assessment theory, and users' perspectives...
November 9, 2017: Medical Teacher
https://www.readbyqxmd.com/read/29116373/the-fundamental-theorem-of-natural-selection-with-mutations
#14
William F Basener, John C Sanford
The mutation-selection process is the most fundamental mechanism of evolution. In 1935, R. A. Fisher proved his fundamental theorem of natural selection, providing a model in which the rate of change of mean fitness is equal to the genetic variance of a species. Fisher did not include mutations in his model, but believed that mutations would provide a continual supply of variance resulting in perpetual increase in mean fitness, thus providing a foundation for neo-Darwinian theory. In this paper we re-examine Fisher's Theorem, showing that because it disregards mutations, and because it is invalid beyond one instant in time, it has limited biological relevance...
November 7, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29114178/cancer-metabolism-and-tumor-heterogeneity-imaging-perspectives-using-mr-imaging-and-spectroscopy
#15
REVIEW
Gigin Lin, Kayvan R Keshari, Jae Mo Park
Cancer cells reprogram their metabolism to maintain viability via genetic mutations and epigenetic alterations, expressing overall dynamic heterogeneity. The complex relaxation mechanisms of nuclear spins provide unique and convertible tissue contrasts, making magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) pertinent imaging tools in both clinics and research. In this review, we summarized MR methods that visualize tumor characteristics and its metabolic phenotypes on an anatomical, microvascular, microstructural, microenvironmental, and metabolomics scale...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29110294/chemometric-methods-to-quantify-1d-and-2d-nmr-spectral-differences-among-similar-protein-therapeutics
#16
Kang Chen, Junyong Park, Feng Li, Sharadrao M Patil, David A Keire
NMR spectroscopy is an emerging analytical tool for measuring complex drug product qualities, e.g., protein higher order structure (HOS) or heparin chemical composition. Most drug NMR spectra have been visually analyzed; however, NMR spectra are inherently quantitative and multivariate and thus suitable for chemometric analysis. Therefore, quantitative measurements derived from chemometric comparisons between spectra could be a key step in establishing acceptance criteria for a new generic drug or a new batch after manufacture change...
November 6, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29102054/cognitive-function-in-patients-on-androgen-suppression-a-prospective-multicentric-study
#17
J Morote, Á J Tabernero, J L Álvarez-Ossorio, J P Ciria, J L Domínguez-Escrig, F Vázquez, J Angulo, F J López, R de La Iglesia, J Romero
OBJECTIVE: To assess the effect of androgen deprivation therapy (ADT) on cognitive performance (CP) in patients with prostate cancer (PCa) after 6 months of treatment with luteinizing hormone-releasing hormone (LHRH) analogues. MATERIAL AND METHODS: Prospective, observational, multicentre, open-label study of patients diagnosed with nonmetastatic or asymptomatic metastatic PCa scheduled to receive LHRH analogues for≥6 months. We assessed four CP domains at baseline and after 6 months of ADT: 1) Working memory: Wechsler Adult Intelligence Scale III (WAIS III) Digit Span Subtest (WAIS III-Digit); 2) Visual memory: ad hoc visual memory test; 3) Visuospatial ability: Judgement of Line Orientation (JLO) and Mental Rotation of Three-Dimensional Objects (3D-Rotation); and 4) Nonverbal analytical reasoning: WAIS III Matrix Reasoning Test (WAIS III-MRT)...
October 25, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29101720/dissociable-effects-of-irrelevant-context-on-2d-and-3d-grasping
#18
Aviad Ozana, Tzvi Ganel
Grasping movements directed toward real objects are typically unaffected by irrelevant aspects of the object and its surroundings, indicating that such interactions are based on analytic processing of object shape and size. However, recent findings show that grasping directed toward two-dimensional (2D) objects is subjected to perceptually mediated effects of relative shape and size. It is unclear however, whether context-dependent processing-a hallmark of visual perception-affects 2D grasping in the same fashion...
November 3, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29099113/mapeo-geoepidemiol%C3%A3-gico-en-la-nueva-vigilancia-de-salud-p%C3%A3%C2%BAblica-el-caso-de-la-malaria-en-chiapas-m%C3%A3-xico-en-2002
#19
Carlos Castillo-Salgado
The new public health surveillance requires at the global, national and local levels the use of new authoritative analytical approaches and tools for better recognition of the epidemiologic characteristics of the priority health events and risk factors affecting the population health. The identification of the events in time and space is of fundamental importance so that the geo-spatial description of the situation of diseases and health events facilitates the identification of social, environmental and health care related risks...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29098643/using-3d-printing-for-rapid-prototyping-of-characterization-tools-for-investigating-powder-blend-behavior
#20
Cosima Hirschberg, Johan P Boetker, Jukka Rantanen, Miriam Pein-Hackelbusch
There is an increasing need to provide more detailed insight into the behavior of particulate systems. The current powder characterization tools are developed empirically and in many cases, modification of existing equipment is difficult. More flexible tools are needed to provide understanding of complex powder behavior, such as mixing process and segregation phenomenon. An approach based on the fast prototyping of new powder handling geometries and interfacing solutions for process analytical tools is reported...
November 2, 2017: AAPS PharmSciTech
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