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https://www.readbyqxmd.com/read/28920902/a-visual-analytics-framework-for-identifying-topic-drivers-in-media-events
#1
Yafeng Lu, Hong Wang, Steven Landis, Ross Maciejewski
Media data has been the subject of large scale analysis with applications of text mining being used to provide overviews of media themes and information flows. Such information extracted from media articles has also shown its contextual value of being integrated with other data, such as criminal records and stock market pricing. In this work, we explore linking textual media data with curated secondary textual data sources through user-guided semantic lexical matching for identifying relationships and data links...
September 14, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28917808/single-drop-gold-nanoparticles-for-headspace-microextraction-and-colorimetric-assay-of-mercury-ii-in-environmental-waters
#2
Tesfaye Tolessa, Zhi-Qiang Tan, Yong-Guang Yin, Jing-Fu Liu
A novel headspace colorimetric nanosensor strategy for specific detection of Hg(II) was developed based upon analyte induced etching and amalgamation of gold nanoparticles (AuNPs). The Hg(II) was first selectively reduced to its volatile form, Hg(0), by stannous chloride (SnCl2) through chemical cold vapor generation (CVG) reaction. Then, the Hg(0) was headspace extracted into 37μL thioglycolic acid functionalized AuNP aqueous suspension containing 10% methanol as extractant and simultaneously reacted with AuNPs through the strong metallophilic Hg-Au interaction, resulting in a red-to-blue color change...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917212/comparative-analytical-and-toxicological-assessment-of-methylcyclohexanemethanol-mchm-mixtures-associated-with-the-elk-river-chemical-spill
#3
Katharine A Horzmann, Chloe de Perre, Linda S Lee, Andrew J Whelton, Jennifer L Freeman
On January 9, 2014, a chemical mixture containing crude methylcyclohexanemethanol (MCHM) contaminated the water supply of Charleston, West Virginia. Although the mixture was later identified as a mix of crude MCHM and stripped propylene glycol phenyl ethers, initial risk assessment focused on 4-MCHM, the predominant component of crude MCHM. The mixture's exact composition and the toxicity differences between 4-MCHM, crude MCHM, and the tank mixture were unknown. We analyzed the chemical composition of crude MCHM and the tank mixture via GC/MS and, based on identified spectra, found that crude MCHM and the tank mixture differed in chemical composition...
September 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28917048/imaging-of-selenium-by-laser-ablation-inductively-coupled-plasma-mass-spectrometry-la-icp-ms-in-2-d-electrophoresis-gels-and-biological-tissues
#4
Elisa Castañeda Santa Cruz, J Susanne Becker, J Sabine Becker, Alessandra Sussulini
Selenium and selenoproteins are important components of living organisms that play a role in different biological processes. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a powerful analytical technique that has been employed to obtain distribution maps of selenium in biological tissues in a direct manner, as well as in selenoproteins, previously separated by their molecular masses and isoelectric points using two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). In this chapter, we present the protocols to perform LA-ICP-MS imaging experiments, allowing the distribution visualization and determination of selenium and/or selenoproteins in biological systems...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28916104/highly-selective-and-sensitive-visualization-and-identification-of-glycoproteins-using-multi-functionalized-soluble-dendrimer
#5
Tiantian Li, Zhenlong Yu, Liyuan Zhang, Chao Wang, Sa Deng, Xiaokui Huo, Xiangge Tian, Baojing Zhang, Xiaochi Ma
Glycoproteins are the most important and complex group of posttranslational modifications known in proteins. Many clinical biomarkers and therapeutic targets in cancer are glycoproteins. However, the isolation of glyco-specific antibodies and their poor stability remains a significant challenge in analytical method and diagnostic development. In this work, for the first time, we present a technology for highly efficient and selective glycosylation analysis on membrane without the use of glyco-specific antibodies...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28911967/applications-of-nuclear-magnetic-resonance-in-lipid-analyses-an-emerging-powerful-tool-for-lipidomics-studies
#6
REVIEW
Jingbo Li, Thomas Vosegaard, Zheng Guo
The role of lipids in cell, tissue, and organ physiology is crucial; as many diseases, including cancer, diabetes, neurodegenerative, and infectious diseases, are closely related to absorption and metabolism of lipids. Mass spectrometry (MS) based methods are the most developed powerful tools to study the synthetic pathways and metabolic networks of cellular lipids in biological systems; leading to the birth of an emerging subject lipidomics, which has been extensively reviewed. Nuclear magnetic resonance (NMR), another powerful analytical tool, which allows the visualization of single atoms and molecules, is receiving increasing attention in lipidomics analyses...
September 11, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28911223/direct-sampling-and-analysis-of-atmospheric-particulate-organic-matter-by-proton-transfer-reaction-mass-spectrometry
#7
Markus Muller, Philipp Eichler, Barbara D'Anna, Wen Tan, Armin Wisthaler
We report on a new method for analyzing atmospheric submicrometer particulate organic matter which combines direct particle sampling and volatilization with on-line chemical ionization mass spectrometric analysis. Technically, the method relies on the combined use of a CHARON ("Chemical Analysis of Aerosol On-line") particle inlet and a proton-transfer-reaction time-of-flight mass spectrometer (PTR-ToF-MS). Laboratory studies on target analytes showed that the ionization conditions in the PTR-ToF-MS lead to extensive fragmentation of levoglucosan and cis-pinonic acid, while protonated oleic acid and 5-cholestane molecules remain intact...
September 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28902396/data-analysis-pipeline-for-rna-seq-experiments-from-differential-expression-to-cryptic-splicing
#8
Hari Krishna Yalamanchili, Ying-Wooi Wan, Zhandong Liu
RNA sequencing (RNA-seq) is a high-throughput technology that provides unique insights into the transcriptome. It has a wide variety of applications in quantifying genes/isoforms and in detecting non-coding RNA, alternative splicing, and splice junctions. It is extremely important to comprehend the entire transcriptome for a thorough understanding of the cellular system. Several RNA-seq analysis pipelines have been proposed to date. However, no single analysis pipeline can capture dynamics of the entire transcriptome...
September 13, 2017: Current Protocols in Bioinformatics
https://www.readbyqxmd.com/read/28901607/bias-variance-tradeoff-in-anticorrelated-noise-reduction-for-spectral-ct
#9
Mats Persson, Fredrik Grönberg
PURPOSE: In spectral CT, basis material decomposition is commonly used to generate a set of basis images showing the material composition at each point in the field of view. The noise in these images typically contains anticorrelations between the different basis images, which leads to increased noise in each basis image. These anticorrelations can be removed by changing the basis functions used in the material decomposition, but the resulting basis images can then no longer be used for quantitative measurements...
September 2017: Medical Physics
https://www.readbyqxmd.com/read/28899371/simultaneous-detection-of-%C3%AE-lactoalbumin-%C3%AE-lactoglobulin-and-lactoferrin-in-milk-by-visualized-microarray
#10
Zhoumin Li, Fang Wen, Zhonghui Li, Nan Zheng, Jindou Jiang, Danke Xu
BACKGROUND: α-Lactalbumin (a-LA), β-lactoglobulin (β-LG) and lactoferrin (LF) are of high nutritional value which have made ingredients of choice in the formulation of modern foods and beverages. There remains an urgent need to develop novel biosensing methods for quantification featuring reduced cost, improved sensitivity, selectivity and more rapid response, especially for simultaneous detection of multiple whey proteins. RESULTS: A novel visualized microarray method was developed for the determination of a-LA, β-LG and LF in milk samples without the need for complex or time-consuming pre-treatment steps...
September 12, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28895928/collaborative-visual-analytics-a-health-analytics-approach-to-injury-prevention
#11
Samar Al-Hajj, Brian Fisher, Jennifer Smith, Ian Pike
Background: Accurate understanding of complex health data is critical in order to deal with wicked health problems and make timely decisions. Wicked problems refer to ill-structured and dynamic problems that combine multidimensional elements, which often preclude the conventional problem solving approach. This pilot study introduces visual analytics (VA) methods to multi-stakeholder decision-making sessions about child injury prevention; Methods: Inspired by the Delphi method, we introduced a novel methodology-group analytics (GA)...
September 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28894051/standardization-of-the-collection-of-exhaled-breath-condensate-and-exhaled-breath-aerosol-using-a-feedback-regulated-sampling-device
#12
Brett R Winters, Joachim D Pleil, Michelle M Angrish, Matthew A Stiegel, Terence H Risby, Michael C Madden
Exhaled breath condensate (EBC) and associated exhaled breath aerosols (EBA) are valuable non-invasive biological media used for the quantification of biomarkers. EBC contains exhaled water vapor, soluble gas-phase (polar) organic compounds, ionic species, plus other species including semi- and non-volatile organic compounds, proteins, cell fragments, DNA, dissolved inorganic compounds, ions, and micro-biota (bacteria and viruses) dissolved in the co-collected EBA. EBC is collected from subjects who breathe "normally" through a chilled tube assembly for approximately 10 minutes and is then harvested into small vials for analysis...
September 12, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28892607/template-free-synthesis-of-highly-porous-boron-nitride-insights-into-pore-network-design-and-impact-on-gas-sorption
#13
Sofia Marchesini, Catriona M McGilvery, Josh Bailey, Camille Petit
Production of biocompatible and stable porous materials, e.g., boron nitride, exhibiting tunable and enhanced porosity is a prerequisite if they are to be employed to address challenges such as drug delivery, molecular separations, or catalysis. However, there is currently very limited understanding of the formation mechanisms of porous boron nitride and the parameters controlling its porosity, which ultimately prevents exploiting the material's full potential. Herein, we produce boron nitride with high and tunable surface area and micro/mesoporosity via a facile template-free method using multiple readily available N-containing precursors with different thermal decomposition patterns...
September 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28892232/visualization-of-stereoselective-supramolecular-polymers-via-chirality-controlled-energy-transfer
#14
Aritra Sarkar, Shikha Dhiman, Aditya Chalishazar, Subi J George
Chirality driven self-sorting is envisaged to efficiently control functional properties in supramolecular materials. However, it faces challenge due to lack of analytical methods to directly monitor the enantioselectivity of resulting supramolecular assemblies. In this context, we present two fluorescent core-substituted naphthalene diimide based donor and acceptor molecules with minimal structural mismatch and comprising of strong self-recognizing chiral motif, for solely chirality to determine the self-sorting process...
September 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28887274/the-qualitative-grading-of-muscle-fat-infiltration-in-whiplash-using-fat-water-magnetic-resonance-imaging
#15
Rebecca Abbott, Anneli Peolsson, Janne West, James M Elliott, Ulrika Åslund, Anette Karlsson, Olof Dahlqvist Leinhard
BACKGROUND CONTEXT: Development of muscle fat infiltration (MFI) in the neck muscles is associated with poor functional recovery following whiplash injury. Custom software and time-consuming manual segmentation of magnetic resonance (MR) images is required for quantitative analysis and presents as a barrier for clinical translation. PURPOSE: The purpose of this work was to establish a qualitative MR measure for MFI and evaluate its ability to differentiate between individuals with severe whiplash-associated disorder (WAD), mild/moderate WAD, and healthy controls...
September 5, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28885154/sequence-synopsis-optimize-visual-summary-of-temporal-event-data
#16
Yuanzhe Chen, Panpan Xu, Liu Ren
Event sequences analysis plays an important role in many application domains such as customer behavior analysis, electronic health record analysis and vehicle fault diagnosis. Real-world event sequence data is often noisy and complex with high event cardinality, making it a challenging task to construct concise yet comprehensive overviews for such data. In this paper, we propose a novel visualization technique based on the minimum description length (MDL) principle to construct a coarse-level overview of event sequence data while balancing the information loss in it...
September 4, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28880181/eva-visual-analytics-to-identify-fraudulent-events
#17
Roger A Leite, Theresia Gschwandtner, Silvia Miksch, Simone Kriglstein, Margit Pohl, Erich Gstrein, Johannes Kuntner
Financial institutions are interested in ensuring security and quality for their customers. Banks, for instance, need to identify and stop harmful transactions in a timely manner. In order to detect fraudulent operations, data mining techniques and customer profile analysis are commonly used. However, these approaches are not supported by Visual Analytics techniques yet. Visual Analytics techniques have potential to considerably enhance the knowledge discovery process and increase the detection and prediction accuracy of financial fraud detection systems...
August 31, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28880180/conceptvector-text-visual-analytics-via-interactive-lexicon-building-using-word-embedding
#18
Deokgun Park, Seungyeon Kim, Jurim Lee, Jaegul Choo, Nicholas Diakopoulos, Niklas Elmqvist
Central to many text analysis methods is the notion of a concept: a set of semantically related keywords characterizing a specific object, phenomenon, or theme. Advances in word embedding allow building a concept from a small set of seed terms. However, naive application of such techniques may result in false positive errors because of the polysemy of natural language. To mitigate this problem, we present a visual analytics system called ConceptVector that guides a user in building such concepts and then using them to analyze documents...
August 31, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28873820/non-visually-performing-analytical-tasks-on-statistical-charts
#19
Tomas Murillo-Morales, Klaus Miesenberger
This article proposes a natural language-based approach to accessibility of charts. Formal underpinnings are used to semantically annotate the constituent elements of a vector graphic to support accessing and modifying the content by natural language queries in a web interface. A prototype which lets blind users perform a number of analytical activities on bar charts is introduced.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28871420/weber-s-law-in-2d-and-3d-grasping
#20
Aviad Ozana, Tzvi Ganel
Visually guided grasping movements directed to real, 3D objects are characterized by a distinguishable trajectory pattern that evades the influence of Weber's law, a basic principle of perception. Conversely, grasping trajectories directed to 2D line drawings of objects adhere to Weber's law. It can be argued, therefore, that during 2D grasping, the visuomotor system fails at operating in analytic mode and is intruded by irrelevant perceptual information. Here, we explored the visual and tactile cues that enable such analytic processing during grasping...
September 4, 2017: Psychological Research
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