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Neuropathy vasculitis

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https://www.readbyqxmd.com/read/27857032/eosinophilic-granulomatosis-with-polyangiitis-presenting-with-skin-rashes-eosinophilic-cholecystitis-and-retinal-vasculitis
#1
Mingbing Zeng, Xialin Liu, Yizhi Liu
BACKGROUND Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome (CSS), is a rare vasculitis of unknown etiology. Most of the patients have a long history of asthma and then develop autoimmune inflammation of small and medium-sized blood vessels, with consequent reduction of blood flow to various organs and tissues. EGPA can cause disorders in multiple systems; the most seriously affected organs are the retina, kidney, brain, cardiovascular system, and skin. CASE REPORT The patient was hospitalized for high fever and skin rashes and then developed right upper abdominal pain, decreased visual acuity, coma, and convulsions...
November 18, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27819416/neurological-manifestations-of-acute-posterior-multifocal-placoid-pigment-epitheliopathy
#2
Hussein Algahtani, Ashjan Alkhotani, Bader Shirah
BACKGROUND AND PURPOSE: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an immune-mediated chorioretinal disease that causes acute visual symptoms with characteristic ophthalmoscopic findings. Neurological complications are rarely reported in the literature. Here we report two new cases of APMPPE that presented with neurological manifestations, one of which was associated with peripheral neuropathy, which has not been described before. METHODS: A retrospective database review of all patients with a diagnosis of APMPPE was performed...
October 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27796482/-therapeutic-administration-of-immunoglobulins
#3
T Witte
BACKGROUND: Intravenously administered immunoglobulins have multiple modes of action that are anti-inflammatory. They can therefore be beneficial in a number of autoimmune disorders. OBJECTIVE: The aim of this article is to analyze and summarize studies on the administration of intravenous immunoglobulins in rheumatological diseases. METHODS: A selective search and analysis of the literature was carried out related to the mode of action and efficacy of intravenous immunoglobulins in rheumatological diseases...
December 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27725289/virologic-clinical-and-immune-response-outcomes-of-patients-with-hepatitis-c-virus-associated-cryoglobulinemia-treated-with-direct-acting-antivirals
#4
Martín Bonacci, Sabela Lens, María-Carlota Londoño, Zoe Mariño, Maria C Cid, Manuel Ramos-Casals, Jose María Sánchez-Tapias, Xavier Forns, José Hernández-Rodríguez
BACKGROUND & AIMS: Cryoglobulins (circulating immune complexes of polyclonal IgG, monoclonal IgM, and rheumatoid factor) are detected in the circulation of 40% to 60% of patients with chronic hepatitis C virus infection, and cryoglobulinemic vasculitis (CV) is observed in approximately 10% of patients. We aimed to assess the clinical and immune effects of direct-acting antiviral treatment. METHODS: We performed a prospective study of 64 patients with HCV infection with circulating cryoglobulins receiving direct-acting antiviral therapy at a single center in Barcelona, Spain, from January 2014 through April 2016...
October 8, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27672598/analyses-on-the-misdiagnoses-of-25-patients-with-unilateral-optic-nerve-sheath-meningioma
#5
Jun-Feng Mao, Xiao-Bo Xia, Xiang-Bo Tang, Xue-Yong Zhang, Dan Wen
AIM: To investigate clinical features of optic nerve sheath meningioma (ONSM) that was misdiagnosed, and to find methods to reduce the misdiagnoses. METHODS: Retrospective series study. Twenty-five misdisgnosed patients with unilateral ONSM were collected from Jan. 2008 to Jan. 2015 and the clinical records reviewed. RESULTS: Patients were misdiagnosed with acute papillitis most frequently (n=17), immediately followed by optic atrophy (n=8), ischemic optic neuropathy (n=5), acute retrobulbar optic neuritis (n=5), optic disc vasculitis (n=3)...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27640316/international-diagnostic-guidelines-for-patients-with-hcv-related-extrahepatic-manifestations-a-multidisciplinary-expert-statement
#6
Clodoveo Ferri, Manuel Ramos-Casals, Anna Linda Zignego, Luca Arcaini, Dario Roccatello, Alessandro Antonelli, David Saadoun, Anne Claire Desbois, Marco Sebastiani, Milvia Casato, Peter Lamprecht, Alessandra Mangia, Athanasios G Tzioufas, Zobair M Younossi, Patrice Cacoub
Hepatitis C virus (HCV) infection is responsible for both hepatic and extra-hepatic disorders (HCV-EHDs); these latter are correlated on one hand clearly with HCV lymphotropism causing immune-system dysregulation as well as with viral oncogenic potential, and on the other hand probably with chronic inflammatory status causing cardio-metabolic complications as well as neurocognitive disturbances. The spectrum of HCV-EHDs ranges from mild or moderate manifestations, such as arthralgia, sicca syndrome, peripheral neuropathy, to severe, life-threatening complications, mainly vasculitis and neoplastic complications...
September 16, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27636384/neurolymphomatosis-of-the-peripheral-nervous-system-a-case-report-and-review-of-the-literature
#7
Panagiotis A Sideras, John Matthews, S M Nazmus Sakib, Franka Ofikwu, Vadim Spektor
Neurolymphomatosis is a rare neurological syndrome in lymphomas. It is reported as infiltration of peripheral nerves by lymphoma. It is important to distinguish neurolymphomatosis from other types of neuropathies, particularly infectious and inflammatory conditions. However, it is difficult to isolate a cancer-related inflammatory vasculitis and mononeuritis multiplex without definitive histopathologic examination. In this report, we describe a case of non-Hodgkin's lymphoma involving the peroneal nerve and presenting as neurolymphomatosis...
August 26, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27577846/acute-retinal-necrosis-results-in-low-vision-in-a-young-patient-with-a-history-of-herpes-simplex-virus-encephalitis
#8
Sanjeet K Shahi
Acute retinal necrosis (ARN), secondary to herpes simplex encephalitis, is a rare syndrome that can present in healthy individuals, as well as immuno-compromised patients. Most cases are caused by a secondary infection from the herpes virus family, with varicella zoster virus being the leading cause of this syndrome. Potential symptoms include blurry vision, floaters, ocular pain and photophobia. Ocular findings may consist of severe uveitis, retinal vasculitis, retinal necrosis, papillitis and retinal detachment...
August 31, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27570382/vasculitic-neuropathy-in-elderly-a-study-from-a-tertiary-care-university-hospital-in-south-india
#9
Anish Lawrence, Madhu Nagappa, Anita Mahadevan, Arun B Taly
OBJECTIVE: To describe clinical, electrophysiological, and histopathological profile of vasculitic neuropathy in elderly subjects aged 65 years or more. DESIGN: Retrospective chart review. SETTING: Departments of Neurology and Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India. PATIENTS AND METHODS: Elderly subjects, diagnosed vasculitic neuropathy by nerve biopsy over one decade, were studied...
July 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27516038/clinical-and-color-doppler-imaging-features-of-one-patient-with-occult-giant-cell-arteritis-presenting-arteritic-anterior-ischemic-optic-neuropathy
#10
Dragoş Cătălin Jianu, Silviana Nina Jianu, Ligia Petrica, Andrei Gheorghe Marius Motoc, Traian Flavius Dan, Dorela CodruŢa Lăzureanu, Mihnea Munteanu
Anterior ischemic optic neuropathies (AIONs) represent a segmental infarction of the optic nerve head (ONH) supplied by the posterior ciliary arteries (PCAs). Blood supply blockage can occur with or without arterial inflammation. For this reason, there are two types of AIONs: non-arteritic (NA-AION), and arteritic (A-AION), the latter is almost invariably due to giant cell arteritis (GCA). GCA is a primary vasculitis that predominantly affects extracranial medium-sized arteries, particularly the branches of the external carotid arteries (including superficial temporal arteries - TAs)...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27510644/stroke-in-a-young-patient-with-neurosyphilis-and-hiv
#11
Riddhi Patira, Sarah Smith-Benjamin, Jijo J Wang
Syphilis has long been known as the great imitator. Its heterogeneity can manifest in the form of meningitis, space occupying gummas, vasculitis, strokes, cranial neuropathies, myelopathy, dementia, and seizures. The incidence has been rising with each year, mainly in men who have sex with men accounting for 83% of cases. With the coexistence of immunocompromised states, especially HIV (human immunodeficiency virus), the usually chronic and insidious course of tertiary neurosyphilis can be accelerated. Stroke can occur as a result of neurosyphilis in its meningovascular form, and the likelihood of this increases with HIV co-infection, especially in high-risk groups such as intravenous drug users and men who have sex with men...
August 10, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27495301/giant-cell-arteritis-ophthalmic-manifestations-of-a-systemic-disease
#12
REVIEW
Elisabeth De Smit, Eoin O'Sullivan, David A Mackey, Alex W Hewitt
BACKGROUND: Giant cell arteritis (GCA) is a systemic granulomatous vasculitis, primarily affecting medium-large arteries. It has a predilection for the aorta and its major branches, including the carotid and vertebral arteries. Ophthalmic artery involvement frequently leads to irreversible visual loss, and therefore GCA is one of the few true ophthalmic emergencies. GCA, although classified as a large vessel vasculitis, is known to affect smaller-sized vessels, resulting in a multiplicity of signs in the eye, some of which are often missed...
December 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27362698/vasculitic-mononeuritis-multiplex-may-be-misdiagnosed-as-carpal-tunnel-syndrome
#13
Fatemeh Ghazaei, Reza Sabet, Gholam Reza Raissi
Vasculitis is a group of disorders characterized by inflammation and destruction of blood vessels, resulting in ischemic injury to the involved tissue. Sometimes, peripheral neuropathy is one of the first symptoms of systemic vasculitis. Although the classic form of peripheral nervous system vasculitis is mononeuritis multiplex, it can also present as a mononeuritis. In this case report, the patient presented with progressive rapid onset numbness in her right hand for 2 months. She underwent carpal tunnel decompression surgery with initial diagnosis of acute carpal tunnel syndrome but failed to respond to the surgery, and two month later, she presented with foot drop...
June 29, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27299947/a-case-report-of-cutaneous-polyarteritis-nodosa-in-siblings
#14
Toshitaka Kizawa, Yuko Yoto, Miyako Mizukami, Takeshi Tsugawa, Takako Takeuchi, Hotaka Kamasaki, Yasue Ishii-Osai, Toshiharu Yamashita, Kazushige Nagai, Tsukasa Hori, Hiroyuki Tsutsumi
Cutaneous polyarteritis nodosa (CPAN) is characterized by a necrotizing vasculitis of small and medium-sized arteries in the skin, which can be associated with fever, arthralgia, myalgia, and neuropathy, but, unlike polyarteritis nodosa (PAN), there is no visceral involvement. CPAN is rare in childhood. We report two siblings who developed CPAN during childhood. Interestingly, both had Mediterranean fever gene (MEFV) mutation, i.e. heterozygous E148Q. They also shared HLA-A24, -DR15 alleles. Simultaneous occurrence of MEFV mutation and HLA alleles with CPAN has never been reported in Japan...
June 14, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27268757/pediatric-nerve-biopsy-diagnostic-and-treatment-utility-in%C3%A2-tertiary-care-referral
#15
Cristiane M Ida, Peter J Dyck, P James B Dyck, Janean K Engelstad, Wei Wang, Duygu Selcen, John B Bodensteiner, Michelle L Mauermann, Christopher J Klein
BACKGROUND: Pediatric neuropathies are both unique and similar to their adult counterparts, with genetic varieties thought to be more common. The objective of this work was to assess the utility of nerve biopsy in children at a tertiary referral center in light of availability of current genetic testing. METHODS: We retrospectively reviewed the clinical, nerve biopsy, and genetic testing findings of 316 pediatric (age ≤18 years) patients. RESULTS: Median age at diagnosis was 9...
May 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27267327/the-correlation-between-antiphospholipid-syndrome-and-cryoglobulinemia-case-series-of-4-patients-and-review-of-the-literature
#16
Shiber Shachaf, Molad Yair
BACKGROUND: Cryoglobulinemia is an immune-complex-mediated small vessel vasculitis that classically involves the skin, kidneys and peripheral nerves. Antiphospholipid syndrome (APS) is an autoimmune hypercoagulable disorder which causes blood vessel thrombosis. It can present as a multi-organ microthrombotic disorder which is called catastrophic APS. OBJECTIVE: In this case series we aim to describe the diagnostic and management challenges that arise when these two severe disorders simultaneously present in the same patient...
January 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27266701/clinical-manifestations-and-cerebrospinal-fluid-status-in-ocular-syphilis-in-hiv-negative-patients
#17
Ting Dai, Xinjun Wu, Shaona Zhou, Qianqiu Wang, Daning Li
BACKGROUND: Syphilis with ocular involvement has reemerged as a critical health problem. The aim of the present study was to explore the clinical manifestations and cerebrospinal fluid (CSF) status in ocular syphilis in human immunodeficiency virus (HIV)-negative patients. METHODS: The clinical records of patients with ocular syphilis presenting to the Shanghai Xuhui Central Hospital in the period from January 2011 to December 2012 were retrospectively reviewed...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27184909/hypertrophic-pachymeningitis-with-optic-neuropathy-heralding-systemic-vasculitis
#18
Adrian Budhram, Manal Y Gabril, Donald H Lee, J Alexander Fraser
No abstract text is available yet for this article.
May 17, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27110384/epidemiology-of-neurological-manifestations-in-sj%C3%A3-gren-s-syndrome-data-from-the-french-assess-cohort
#19
Guillermo Carvajal Alegria, Dewi Guellec, Xavier Mariette, Jacques-Eric Gottenberg, Emmanuelle Dernis, Jean-Jacques Dubost, Anne-Priscille Trouvin, Eric Hachulla, Claire Larroche, Veronique Le Guern, Divi Cornec, Valérie Devauchelle-Pensec, Alain Saraux
OBJECTIVES: Neurological manifestations seem common in primary Sjögren's syndrome (pSS) but their reported prevalences vary. We investigated the prevalence and epidemiology of neurological manifestations in a French nationwide multicentre prospective cohort of patients with pSS, the Assessment of Systemic Signs and Evolution in Sjögren's syndrome (ASSESS) cohort. METHODS: The ASSESS cohort, established in 2006, includes 395 patients fulfilling American-European Consensus Group criteria for pSS...
2016: RMD Open
https://www.readbyqxmd.com/read/27106525/hepatitis-b-virus-related-cryoglobulinemic-vasculitis-a-multicentre-open-label-study-from-the-gruppo-italiano-di-studio-delle-crioglobulinemie-gisc
#20
Cesare Mazzaro, Luigino Dal Maso, Teresa Urraro, Endri Mauro, Laura Castelnovo, Pietro Casarin, Giuseppe Monti, Valter Gattei, Anna Linda Zignego, Gabriele Pozzato
BACKGROUND: Cryoglobulinemic vasculitis (CV) related to Hepatitis-B Virus (HBV) is rare and its treatment is ill-defined. AIMS: To describe clinical and treatment characteristics of HBV-related CV patients. In addition, the efficacy of treatment with antiviral agent nucleotide (NUC), including Entecavir, Adefovir, and Lamivudine, was explored. METHODS: In four Italian centres, 17 HBV-positive CV patients (median age 56 years, range 45-70) were enrolled...
July 2016: Digestive and Liver Disease
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