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https://www.readbyqxmd.com/read/29754136/unravelling-the-nerds-syndrome
#1
Achintya Dinesh Singh, Tejas Menon Suri, Rakesh Kumar Jagdish, Uma Kumar
A 22-year-old man presented with symmetric polyarthritis, pruritus and deviation of angle of mouth to the right side since the last 7 years. His symptoms were persistent despite receiving ayurvedic medications and symptomatic therapy. Examination revealed dry skin, cutaneous nodules, xanthelasma, periarticular non-tender swellings, pitting oedema of hands and feet and lower motor neuron type right facial palsy. Haematological investigations revealed eosinophilia and skin biopsy had cutaneous eosinophilic infiltration...
May 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29741276/pancreatic-panniculitis-a-case-series-from-a-tertiary-university-hospital-in-spain
#2
Clara Fernández-Sartorio, Andrea Combalia, Joan Ferrando, Mercè Alsina, Pilar Iranzo, Teresa Estrach, Eugenia Hernández-Ruiz, José M Mascaró
Pancreatic panniculitis is a rare type that only occurs in 2-3% of all patients with pancreatic diseases. It is usually described in association with benign pancreatic disease and less commonly in association with pancreatic carcinoma. We describe a case of pancreatic panniculitis as the first manifestation of underlying ampullary adenocarcinoma and a new case of pancreatitis, panniculitis and polyarthritis (PPP-Syndrome). Pancreatic panniculitis may be the cutaneous manifestation of pancreatic allograft rejection after simultaneous pancreas-kidney transplantation...
May 9, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29727898/-immunosuppressive-therapy-in-dogs-and-cats-properties-of-drugs-and-their-use-in-various-immune-mediated-diseases
#3
Johanna Rieder, Reinhard Mischke
Veterinarians are regularly faced with the diagnosis and therapy of immune-mediated diseases. More frequently occurring immune-mediated diseases are immune-mediated hemolytic anemia, immunemediated thrombocytopenia and polyarthritis. Glucocorticoids are commonly used as first-line treatment because of their availability, efficacy and rapid action. Nevertheless, some patients do not respond to glucocorticoid therapy alone. Others require a rapid dose reduction because of severe side effects from glucocorticoid treatment...
April 2018: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/29723378/oral-mucosa-lesions-as-atypical-manifestation-of-adult-onset-still%C3%A2-s-disease
#4
María Lorena Brance, Eldo Luis Neffen
Adult-onset Still's disease is a systemic inflammatory disorder of unknown etiology, characterized by skin rash, spiking fever, arthralgias or arthritis, and leukocytosis. The typical skin rash is evanescent, salmon-pink, nonpruritic and maculopapular, predominantly on the extremities. It is considered one of the major Yamaguchi's criteria in adult-onset Still's disease. However, atypical skin lesions are also described. Here, a 61-year-old woman with sore throat, spiking fever, polyarthritis and evanescent salmon-pink nonpruritic maculopapular skin rash on the extremities was diagnosed with adult-onset Still's disease...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29685215/the-major-membrane-nuclease-mnua-degrades-neutrophil-extracellular-traps-induced-by-mycoplasma-bovis
#5
Filimon Mitiku, Carol A Hartley, Fiona M Sansom, Joanne E Coombe, Peter D Mansell, David S Beggs, Glenn F Browning
Mycoplasma bovis has been increasingly recognised worldwide as an economically important pathogen of cattle, causing a range of diseases, including pneumonia, mastitis, polyarthritis and otitis media. It is believed that M. bovis utilises a range of cell surface proteins, including nucleases, to evade the host immune response and survive. However, despite the importance of neutrophils in controlling pathogenic bacteria, the interaction between these cells and M. bovis is not well-characterised. In addition to phagocytosis, neutrophils combat pathogens through the release of neutrophil extracellular traps (NETs), which are composed of their nuclear and granular components, including DNA...
May 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29681086/a-novel-homozygous-mutation-in-the-slco2a1-gene-causing-pachydermoperiostosis-efficacy-of-hydroxychloroquine-treatment
#6
Annalisa Alessandrella, Roberto Della Casa, Maria Alessio, Jorge Puente Prieto, Pietro Strisciuglio, Daniela Melis
Pachydermoperiostosis (PDP), otherwise known as primary hypertrophic osteoarthropathy, is characterized by digital clubbing, pachydermia and subperiosteal new bone formation. Joint pain, polyarthritis, cutis verticis gyrata, seborrhea, and hyperhidrosis are frequently associated to this condition. We report a 17-year-old boy presented with pain and swelling of knees and ankles, and progressive thickening of skin face with seborrhea from about 4 years. At the admission he also showed digital clubbing of both hands and feet and palmoplantar hyperhidrosis...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29678361/chikungunya-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#7
Pravin Amin, Gisele Sampaio Silva, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Dilip R Karnad, Guy A Richards
Chikungunya is an arbovirus that is transmitted by the Aedes mosquito causing a febrile illness with periodic outbreaks in large parts of the world. In the last decade it has become a public health concern in a host of countries and has affected international tourists. In the vast majority of cases Chikungunya presents as an acute febrile illness, associated with rash, headache, myalgia and debilitating arthralgia or even polyarthritis. A small proportion of patients present atypically with nervous, ocular, renal, myocardial, respiratory and renal system involvement and may require ICU management...
April 7, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29664389/cerebrospinal-fluid-immunoglobulins-as-potential-biomarkers-of-chikungunya-encephalitis
#8
Marzia Puccioni-Sohler, Luiz Claudio Farias, Mauro Jorge Cabral-Castro, Mariano G Zalis, Rosangela S Kalil, Maria Cecília F Salgado
Chikungunya virus causes fever and severe polyarthritis or arthralgia and is associated with neurologic manifestations that are sometimes challenging to diagnose. We demonstrate intrathecal synthesis of chikungunya antibodies in a patient with a history of acute infection complicated by encephalitis. The specificity of the intracerebral immune response supports early chikungunya-associated encephalitis diagnosis.
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29657151/crystal-proven-gout-and-characteristic-gout-severity-factors-are-associated-with-cardiovascular-disease
#9
Iris J M Disveld, Jaap Fransen, Gerard A Rongen, Laura B E Kienhorst, Sahel Zoakman, Hein J E M Janssens, Matthijs Janssen
OBJECTIVE: Our aim was to examine the prevalence of cardiovascular disease (CVD) in patients with crystal-proven gout compared to arthritis controls. Further, we analyzed the association between characteristic gout severity factors and CVD to provide further support for a pathogenetic relationship between gout and CVD. METHODS: Patients with arthritis referred for diagnosis were consecutively included in the Gout Arnhem-Liemers cohort. Joint fluid analysis was performed in all referred patients; controls were negative for crystals...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29648683/long-term-outcomes-following-achievement-of-clinically-inactive-disease-in-juvenile-idiopathic-arthritis-the-importance-of-definition
#10
Stephanie Jw Shoop-Worrall, Suzanne Mm Verstappen, Janet E McDonagh, Eileen Baildam, Alice Chieng, Joyce Davidson, Helen Foster, Yiannis Ioannou, Flora McErlane, Lucy R Wedderburn, W Thomson, Kimme L Hyrich
BACKGROUND: Potential targets for treat-to-target strategies in JIA are minimal disease activity (MDA) and clinically inactive disease (CID). Short and long-term outcomes following achievement of MDA and CID on the cJADAS10 and CID on Wallace's preliminary criteria were compared. METHODS: Children recruited to the Childhood Arthritis Prospective Study, a UK multicentre inception cohort, were selected if recruited prior to January 2011 and diagnosed with oligoarthritis or rheumatoid factor negative or positive polyarthritis...
April 12, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29618659/mesenchymal-tnfr2-promotes-the-development-of-polyarthritis-and-comorbid-heart-valve-stenosis
#11
Maria Sakkou, Panagiotis Chouvardas, Lydia Ntari, Alejandro Prados, Kristin Moreth, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Maria C Denis, Niki Karagianni, George Kollias
Mesenchymal TNF signaling is etiopathogenic for inflammatory diseases such as rheumatoid arthritis and spondyloarthritis (SpA). The role of Tnfr1 in arthritis has been documented; however, Tnfr2 functions are unknown. Here, we investigate the mesenchymal-specific role of Tnfr2 in the TnfΔARE mouse model of SpA in arthritis and heart valve stenosis comorbidity by cell-specific, Col6a1-cre-driven gene targeting. We find that TNF/Tnfr2 signaling in resident synovial fibroblasts (SFs) and valvular interstitial cells (VICs) is detrimental for both pathologies, pointing to common cellular mechanisms...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29618462/allogeneic-hematopoietic-stem-cell-transplantation-for-severe-refractory-juvenile-idiopathic-arthritis
#12
Juliana M F Silva, Fani Ladomenou, Ben Carpenter, Sharat Chandra, Petr Sedlacek, Renata Formankova, Vicky Grandage, Mark Friswell, Andrew J Cant, Zohreh Nademi, Mary A Slatter, Andrew R Gennery, Sophie Hambleton, Terence J Flood, Giovanna Lucchini, Robert Chiesa, Kanchan Rao, Persis J Amrolia, Paul Brogan, Lucy R Wedderburn, Julie M Glanville, Rachael Hough, Rebecca Marsh, Mario Abinun, Paul Veys
Patients with juvenile idiopathic arthritis (JIA) can experience a severe disease course, with progressive destructive polyarthritis refractory to conventional therapy with disease-modifying antirheumatic drugs including biologics, as well as life-threatening complications including macrophage activation syndrome (MAS). Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative immunomodulatory strategy for patients with such refractory disease. We treated 16 patients in 5 transplant centers between 2007 and 2016: 11 children with systemic JIA and 5 with rheumatoid factor-negative polyarticular JIA; all were either refractory to standard therapy, had developed secondary hemophagocytic lymphohistiocytosis/MAS poorly responsive to treatment, or had failed autologous HSCT...
April 10, 2018: Blood Advances
https://www.readbyqxmd.com/read/29615263/understanding-the-health-and-production-impacts-of-endemic-chlamydia-pecorum-infections-in-lambs
#13
Evelyn Walker, Martina Jelocnik, Sankhya Bommana, Peter Timms, Scott Carver, Adam Polkinghorne
Lamydia pecorum is a globally recognised livestock pathogen that is capable of causing severe and economically significant diseases such as arthritis in sheep and cattle. Relatively little information is available on the clinical progression of disease and the long-term effects of asymptomatic and symptomatic chlamydiosis in sheep. Recent studies in calves indicate that endemic C. pecorum infections may reduce growth rates. To investigate the clinical health parameters and production impacts of endemic C. pecorum infection in an Australian commercial lamb flock, we performed bimonthly sampling and clinical health assessments on 105 Border Leicester lambs from two to ten months of age...
April 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29610698/three-case-reports-of-rhupus-syndrome-an-overlap-syndrome-of-rheumatoid-arthritis-and-systemic-lupus-erythematosus
#14
Gul Devrimsel, Munevver Serdaroglu Beyazal
We present the clinical and serological characteristics of three patients with rhupus. The 3 patients with rhupus presented ACR criteria for SLE as well as for RA, ANA positive with a titer of 1/100 in all patients, and positive anti-DNA in 2 of the 3 patients, with the predominance of symmetrical polyarthritis. We found anti-CCP positivity and rheumatoid factor positivity and high titers in all patients, positive anti- anti-SSA in one patient, and positive anti- anti-Sm in one patient. Renal and liver function tests were normal in all patients...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29609005/decreased-pd-1-expression-on-circulating-cd4-t-cell-and-pd-l1-expression-on-myeloid-dendritic-cells-correlate-with-clinical-manifestations-in-systemic-juvenile-idiopathic-arthritis
#15
Li Cai, Chenxing Zhang, Jing Wu, Wei Zhou, Tongxin Chen
OBJECTIVES: Programmed cell death-1 (PD-1) and its ligand (PD-L1) mediate negative signal in autoimmune diseases. While little is known about its role in juvenile idiopathic arthritis (JIA). The study aimed to reveal the circulating cell profile and the relative PD-1/PD-L1 expression of JIA subsets, elucidating their underlying immunomodulatory mechanisms. METHODS: We detected the circulating cells and the relative PD-1/PD-L1 signaling in 101 JIA patients and 50 controls by flowcytometry and analyzed their association with disease activity and clinical manifestations...
March 30, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29606669/flares-of-disease-in-children-with-clinically-inactive-juvenile-idiopathic-arthritis-were-not-correlated-with-ultrasound-findings
#16
Yongdong Zhao, Nanci E Rascoff, Ramesh S Iyer, Mahesh Thapa, Lucas Reichley, Assaf P Oron, Carol A Wallace
OBJECTIVE: The validity of our current definitions for clinically inactive disease (CID) in juvenile idiopathic arthritis (JIA) based on physical examination is challenged by the development of advanced musculoskeletal imaging tools. We aimed to prospectively determine the prevalence of abnormal ultrasound (US) findings in children with CID in JIA and their clinical significance. METHODS: Children aged ≥ 4 years with CID and a history of arthritis from a single tertiary center were approached over 1 year...
April 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29602165/sonographic-evaluation-of-salivary-glands-in-juvenile-sj%C3%A3-gren-s-syndrome
#17
Vanessa Ramos Guissa, Evelyne Lopes Martinelli, Letícia Maria Kolachinski Raposo Brandão, Leandro Diniz Garcia, José Roberto Provenza, José Alexandre Mendonça
IIntroduction: Sjögren's syndrome in childhood is a rare autoimmune disease and mostly under-diagnosed. The aim of this study is to highlight the importance of ultrasonographic assessment of the salivary glands in children with recurrent parotitis and positive autoantibodies. Two cases of ultrasonographic patterns typical of Sjögren's syndrome have been described below. Case 1: Female, 7 years old, reporting for 2 years recurrent parotitis, xerophthalmia, xerostomia, polyarthralgia and fever. Immunological tests were positive for antinuclear antibodies, rheumatoid factor, anti-SSA/Ro and anti-SSB/La...
January 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29600947/disease-activity-overweight-physical-activity-and-screen-time-in-a-cohort-of-patients-with-juvenile-idiopathic-arthritis
#18
Gilad Sherman, Dan Nemet, Veronica Moshe, Alessandro Consolaro, Angelo Ravelli, Nicolino Ruperto, Yosef Uziel
OBJECTIVES: Physical activity is an important part of children's health and social development. Juvenile idiopathic arthritis (JIA) can lead to decreased physical activity and quality of life. This study characterised clinical aspects, physical activity rates, obesity, and screen time in a group of JIA patients. METHODS: Ninety-seven JIA patients in the Paediatric Rheumatology Clinic at Meir Medical Center were evaluated over a 6-month period and compared by statistical methods to 98 age-matched healthy controls...
March 21, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29595396/clinical-findings-and-diagnostic-test-results-for-calves-with-septic-arthritis-64-cases-2009-2014
#19
Caroline Constant, Sylvain Nichols, André Desrochers, Marie Babkine, Gilles Fecteau, Hélène Lardé, Julie-Hélène Fairbrother, David Francoz
OBJECTIVE To describe clinical findings and diagnostic test results and identify potential prognostic indicators for calves with septic arthritis. DESIGN Retrospective case series. ANIMALS 64 calves with septic arthritis. PROCEDURES The medical record database for a veterinary teaching hospital was searched to identify calves ≤ 6 months old that were treated for septic arthritis between 2009 and 2014. Data evaluated included signalment, history, physical examination and diagnostic test results, treatment, and outcome...
April 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29579372/remitting-seronegative-symmetrical-synovitis-with-pitting-edema-rs3pe-associated-with-partial-melanoma-response-under-anti-ctla-4-and-anti-pd-1-combination
#20
Mona Amini-Adle, Muriel Piperno, Jérémie Tordo, Valérie Dubois, Aurélien Marabelle, Luc Thomas, Stéphane Dalle
The patient, a-70-year-old male developed severe inflammatory polyarthritis associated with diffuse pitting edema in the hands and feet (A) six weeks after the initiation of ipilimumab and nivolumab for a heavily metastatic melanoma (B). Synovitis was present in wrists, metacarpophalangeal, and proximal interphalangeal joints. C-reactive protein level was elevated (169 comparing to 7 before immunotherapy introduction). This article is protected by copyright. All rights reserved.
March 26, 2018: Arthritis & Rheumatology
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