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https://www.readbyqxmd.com/read/29167188/severe-panniculitis-and-polyarthritis-caused-by-acinar-cell-carcinoma-arising-from-an-ectopic-pancreas
#1
Marc Plier, Patrick Durez, Mina Komuta, Alexandros Raptis
The pancreatitis, panniculitis and polyarthritis (PPP) syndrome is a rare condition caused by pancreatic diseases, such as acute or chronic pancreatitis or pancreatic carcinoma. We report the first case of PPP syndrome caused by metastatic acinar cell carcinoma from an ectopic pancreas. The symptoms were successfully managed by the treatment of the metastatic carcinoma. Pancreatic cytosteatonecrosis should be always considered in a patient who is showing symptoms of panniculitis and polyarthritis.
November 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29163955/extra-osseous-99m-tc-methylene-diphosphonate-uptake-detected-enlargement-of-the-knee-joint-in-patient-with-polyarthritis
#2
Maria Grazia Caprio, Mariarosaria Manganelli, Simona Limone, Massimiliano Sorbillo, Mario Quarantelli, Alberto Cuocolo, Ciro Gabriele Mainolfi
Bone scintigraphy is a nuclear scanning test used to find abnormalities in the skeleton. Certain abnormal processes involving soft tissues can also cause skeletal accumulation of radiotracer during bone scintigraphy. We present a case of periarticular knee soft tissue (99m)Tc methylene diphosphonate uptake in a patient with asymmetric polyarthritis. A 33-year-old patient with asymmetric polyarthritis, skin lesions and joint pain underwent bone scintigraphy. Total body examination showed an extra-osseous uptake in periarticular soft tissue of knees joints...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29149964/chikungunya-infection-in-solid-organ-transplant-recipients
#3
E S Girão, B G Rodrigues Dos Santos, E S do Amaral, P E G Costa, K B Pereira, A H de Araujo Filho, E B Hyppolito, M U Mota, L C B F Marques, C M Costa de Oliveira, S L da Silva, J H P Garcia, P F C B C Fernandes
BACKGROUND: Chikungunya virus (CHIKV) is an emerging mosquito-borne disease that causes acute febrile polyarthralgia and arthritis. CHIKV has spread rapidly to the Americas and, in Brazil, autochthonous cases are increasingly been reported. Solid organ transplant (SOT) recipients who travel to or live in CHIKV endemic areas are under high risk of acquiring the disease. Few data exist regarding the clinical characteristics of CHIKV infections in this population. We report the first case series of CHIKV infection in SOT recipients...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29132386/primary-single-suture-anchor-re-fixation-of-anterior-cruciate-ligament-proximal-avulsion-tears-leads-to-good-functional-mid-term-results-a-preliminary-study-in-12-patients
#4
Christof Hoffmann, Jan Friederichs, Christian von Rüden, Christian Schaller, Volker Bühren, Christoph Moessmer
BACKGROUND: Current studies demonstrate encouraging short-term results after primary anterior cruciate ligament (ACL) suture anchor repair. However, earlier studies reported deterioration of knee function at 5-year follow-up following good clinical short-term recovery. Therefore, the aim of this study was to evaluate clinical long-term results after primary ACL repair at a minimum 5-year follow-up. METHODS: In a retrospective study, 13 patients were included between 2009 and 2012...
November 13, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29126664/fatal-dress-syndrome-under-tocilizumab-treatment-for-seronegative-polyarthritis
#5
Benoit Ben Said, Mathieu Gerfaud-Valentin, Pascal Seve
No abstract text is available yet for this article.
November 7, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29125905/arthritis-after-cancer-immunotherapy-symptom-duration-and-treatment-response
#6
Melanie H Smith, Anne R Bass
OBJECTIVE: Musculoskeletal manifestations of immune related adverse events (irAEs) after checkpoint inhibitor immunotherapy for cancer remain incompletely characterized and poorly understood. A recently published case series suggested that immunotherapy-induced arthritis is an aggressive process requiring high dose corticosteroids. METHODS: This was a retrospective chart review of all patients with musculoskeletal irAEs first seen by one of the authors between 2014 and 2016...
November 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29120570/early-referral-improves-long-term-outcomes-in-rheumatoid-arthritis
#7
Jobie Evans, Andra Negoescu
Rheumatoid arthritis (RA) is a common, chronic systemic inflammatory disease of unclear aetiology leading to synovial hypertrophy and joint inflammation. It typically presents with symmetrical polyarthritis of small joints of the hands or feet, but can also involve larger joints, and have associated extra-articular manifestations. Diagnosis is based on duration of symptoms, joint distribution, level of inflammatory markers and autoantibodies i.e. rheumatoid factor(RhF) and anty-cyclic citrullinated peptide (CCP) antibodies...
May 2017: Practitioner
https://www.readbyqxmd.com/read/29119304/is-thrombocytosis-always-an-indicator-of-autosplenectomy-in-patients-with-systemic-lupus-erythematosus
#8
Döndü Üsküdar Cansu, Hava Üsküdar Teke, Ahmet Musmul, Cengiz Korkmaz
In systemic lupus erythematosus (SLE), the most commonly encountered finding related to platelets is thrombocytopenia whereas thrombocytosis is rarely reported. Our aim here was to reveal the type and the frequency of thrombocytosis in SLE patients along with its causes. Data of patients were evaluated retrospectively. Patients who had a platelet count of > 450,000/mm(3) (> 450 × 10(9)/L) in at least two subsequent counts and lasting more than 6 months during the follow-up were considered to have "persistent thrombocytosis"...
November 8, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29118755/apoptotic-cells-induced-signaling-for-immune-homeostasis-in-macrophages-and-dendritic-cells
#9
REVIEW
Uriel Trahtemberg, Dror Mevorach
Inefficient and abnormal clearance of apoptotic cells (efferocytosis) contributes to systemic autoimmune disease in humans and mice, and inefficient chromosomal DNA degradation by DNAse II leads to systemic polyarthritis and a cytokine storm. By contrast, efficient clearance allows immune homeostasis, generally leads to a non-inflammatory state for both macrophages and dendritic cells (DCs), and contributes to maintenance of peripheral tolerance. As many as 3 × 10(8) cells undergo apoptosis every hour in our bodies, and one of the primary "eat me" signals expressed by apoptotic cells is phosphatidylserine (PtdSer)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29105868/successful-treatment-of-disseminated-nocardiosis-caused-by-nocardia-veterana-in-a-dog
#10
S Yaemsiri, J E Sykes
A 5-year-old male castrated Lhasa Apso cross was evaluated for a 1-month history of inappetence, lethargy, gagging, and progressive right thoracic limb lameness. Synovial fluid analysis revealed nonseptic suppurative inflammation, and a diagnosis of immune-mediated polyarthritis (IMPA) was made. After 3 months of treatment with prednisone and later cyclosporine, the dog developed multiple firm cutaneous and subcutaneous masses and a focal mass within the jejunum. Cultures of blood, urine, skin lesions, and the jejunal mass identified Nocardia veterana by matrix-absorption laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and allowed for earlier identification of the organism compared to more traditional secA1 gene sequencing...
November 4, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29095500/type-1-immune-mediated-polyarthritis-in-dogs-and-lack-of-a-temporal-relationship-to-vaccination
#11
O A Idowu, K L Heading
OBJECTIVES: To investigate whether there is a temporal relationship between vaccination and the onset of type 1 immune-mediated polyarthritis in dogs. MATERIALS AND METHODS: Retrospective case-control study: 39 dogs from a referral hospital with a diagnosis of type 1 immune-mediated polyarthritis were age-matched with 78 control dogs with other diagnoses. A temporal association between vaccination and polyarthritis was considered positive if recent vaccination had been performed within 28 days of the onset of clinical signs of immune-mediated polyarthritis...
November 2, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29093155/improving-access-to-rheumatologists-use-and-benefits-of-an-electronic-consultation-service
#12
Krista Rostom, C Douglas Smith, Clare Liddy, Amir Afkham, Erin Keely
OBJECTIVE: To describe the use and benefits of an innovative eConsult service to improve access to rheumatologists. METHODS: There were 225 eConsults directed to rheumatology that were categorized by type of question and effect on face-to-face referral rates. RESULTS: The median response time by the rheumatologists was 1.9 days. Clinical questions included drug treatment (34%), diagnosis (26%), or management (14%). Osteoporosis was the most common diagnosis (22%), followed by pain in multiple joints (11%), and polyarthritis (10%)...
November 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29063464/diverse-patterns-of-anti-tnf-%C3%AE-induced-lupus-case-series-and-review-of-the-literature
#13
REVIEW
Ora Shovman, Shalev Tamar, Howard Amital, Abdulla Watad, Yehuda Shoenfeld
The induction of autoantibodies is common following therapy with anti-TNF-α agents. However, anti-TNF-α-induced lupus (ATIL) is rare. We assessed the clinical characteristics of three patients with inflammatory bowel disease (IBD) who were treated with infliximab and developed distinct subsets of ATIL. Also, we searched for similar cases in the published literature. We describe three patients with ATIL. The first patient had a classical drug-induced lupus (DIL) presented by thrombocytopenia that resolved after infliximab discontinuation...
October 23, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29041934/h-syndrome-5-new-cases-from-the-united-states-with-novel-features-and-responses-to-therapy
#14
Jessica L Bloom, Clara Lin, Lisa Imundo, Stephen Guthery, Shelly Stepenaskie, Csaba Galambos, Amy Lowichik, John F Bohnsack
BACKGROUND: H Syndrome is an autosomal recessive disorder characterized by cutaneous hyperpigmentation, hypertrichosis, and induration with numerous systemic manifestations. The syndrome is caused by mutations in SLC29A3, a gene located on chromosome 10q23, which encodes the human equilibrative transporter 3 (hENT3). Less than 100 patients with H syndrome have been described in the literature, with the majority being of Arab descent, and only a few from North America. CASE PRESENTATION: Here we report five pediatric patients from three medical centers in the United States who were identified to have H syndrome by whole exome sequencing...
October 17, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29037524/t-regulatory-cells-triumph-of-perseverance-the-crafoord-prize-for-polyarthritis-in-2017
#15
REVIEW
Frank A Wollheim
The Crafoord Prize in Polyarthritis ranks as one of the most prestigious prizes and can be awarded only if the Royal Swedish Academy of Sciences decides the likelihood of prize worthy progress in the field, and at most every 4th year. This has happened only four times since 1982. This year the 5th Laureates were Shimon Sakaguchi, Fred Ramsdell, and Alexander Rudensky with the motivation "for their discoveries relating to regulatory T cells, which counteract harmful immune reactions in arthritis and other autoimmune diseases"...
September 6, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29021659/occult-renal-cell-carcinoma-presenting-as-carcinomatous-polyarthritis
#16
Mansoor C Abdulla, Ram Narayan, Hazwa K Hamza
Carcinomatous polyarthritis (CP) is a rare paraneoplastic disorder which can be associated with various solid tumors and can even precede detection of the underlying malignancy. A 54-year-old male presented with migratory asymmetric inflammatory polyarthritis and high-grade fever for 6 months. On evaluation, he was diagnosed to have renal cell carcinoma (RCC). CP as an initial presentation of RCC was not described previously.
October 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29021510/treatment-of-rheumatoid-arthritis-with-biological-agents-as-a-typical-and-common-immune-mediated-inflammatory-disease
#17
Tsutomu Takeuchi
Molecules involved in the disease process facilitated our understanding of pathogenesis of the disease with unknown etiology such as immune-mediated and inflammatory diseases. Moreover, the targeted therapies against the proposed molecular targets by biological agents provide enormous benefits to the patients and societies. Here, I will review recent progress of the biological treatment in the immune-inflammatory diseases by focusing on the rheumatoid arthritis, the disease characterized by persistent polyarthritis leading to joint destruction and disability with autoimmune features, as a role model...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/28983415/bilharzial-arthropathy-rare-cause-of-chronic-arthritis-in-tropical-areas
#18
Hoby N Rakotomalala, Maminirina V Ranaivoarison, Francia Andrianjafison, Dimby S Ralandison
Bilharziasis is a parasitic disease that affects the urinary tract and intestines. Finding bilharzia in joints is exceptional. We report two cases of Malagasy patients living in a highly endemic bilharziasis area and having chronic arthritis due to bilharziasis. The first case was a 32-year-old man presenting with a clinical picture of spondylitis with chronic oligoarthritis and paroxysmal asymmetric in his lower limbs, accompanied with sacroiliac pain and episodic dysentery. We retained the diagnosis of bilharziasis arthritis because of positive schistosomiasis serology in the joint fluid and the blood, poor response to therapy with nonsteroidal anti-inflammatory drugs (NSAIDs), and high efficacy of treatment with specific antiparasitic drugs...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28974538/rvx-297-a-bet-bromodomain-inhibitor-has-therapeutic-effects-in-preclinical-models-of-acute-inflammation-and-autoimmune-disease
#19
Ravi Jahagirdar, Sarah Attwell, Suzana Marusic, Alison Bendele, Narmada Shenoy, Kevin G McLure, Dean Gilham, Karen Norek, Henrik C Hansen, Raymond Yu, Jennifer Tobin, Gregory S Wagner, Peter R Young, Norman Cw Wong, Ewelina Kulikowski
Bromodomain and extra-terminal (BET) domain proteins are chromatin adapters that bind acetylated histone marks via two tandem bromodomains (BD1 and BD2) to regulate gene transcription. BET proteins are involved in transcriptional reprogramming in response to inflammatory stimuli. BET bromodomain inhibitors (BETi) that are non-selective for BD1 or BD2 have recognized anti-inflammatory properties in vitro and counter pathology in models of inflammation or autoimmune disease. While both BD1 and BD2 bind acetylated histone residues, they may independently regulate expression of BET sensitive genes...
September 29, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28961556/interstitial-granulomatous-variant-of-scleromyxedema-a-diagnostic-pitfall
#20
Valencia Long, Weisheng Tan, Siong See Joyce Lee, Tien Guan Steven Thng
Scleromyxedema is a rare disorder where patients may develop systemic manifestations such as monoclonal gammopathy, inflammatory polyarthritis, and esophageal and neurological dysfunction. Histologically, there may be atypical variants of scleromyxedema showing features resembling interstitial granuloma annulare. We report an unusual case of scleromyxedema with interstitial granulomatous pattern and highlight potential diagnostic pitfalls when encountered with such a variant.
September 20, 2017: American Journal of Dermatopathology
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