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Phosphatidic acid

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https://www.readbyqxmd.com/read/29786832/the-primary-active-components-antioxidant-properties-and-differential-metabolite-profiles-of-radish-sprouts-raphanus-sativus-l-upon-domestic-storage-analysis-of-nutritional-quality
#1
Ru Li, Yi Zhu
BACKGROUND: This study aimed to analyze the nutritional quality of radish sprouts (Raphanus sativus L.) upon domestic short-term storage. We stored fresh radish sprouts at 25±1°C and at 4±1°C for 12 h, detected phenolic substances, glucosinolates, isothiocyanates, vitamin C, and various antioxidant and abiotic stress-related factors. We investigated nutrient-related metabolic differences and associated pathways and postharvest treatment effects on nutritional quality via metabolomics analysis...
May 21, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29783183/identification-of-novel-phosphatidic-acid-binding-domain-on-sphingosine-kinase-1-of-arabidopsis-thaliana
#2
Shatakshi Pandit, Vikram Dalal, Girish Mishra
Phosphatidic acid (PA) is an important lipid signaling molecule which interacts with Arabidopsis thaliana Sphingosine kinase1 (AtSPHK1) during several abiotic stresses particularly drought stress as a result of Abscisic acid (ABA) signaling in guard cells. PA molecules respond by generating lipid signal and/or by binding and translocating target proteins to membrane. However, site of interaction and role of PA binding to AtSPHK1 is not clear yet. Owing to the importance of AtSPHK1 during stress signaling it is imperative to decipher the site of PA interaction with AtSPHK1...
May 8, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29780359/the-mitotic-and-metabolic-effects-of-phosphatidic-acid-in-the-primary-muscle-cells-of-turbot-scophthalmus-maximus
#3
Tingting Wang, Xuan Wang, Huihui Zhou, Haowen Jiang, Kangsen Mai, Gen He
Searching for nutraceuticals and understanding the underlying mechanism that promote fish growth is at high demand for aquaculture industry. In this study, the modulatory effects of soy phosphatidic acids (PA) on cell proliferation, nutrient sensing, and metabolic pathways were systematically examined in primary muscle cells of turbot ( Scophthalmus maximus ). PA was found to stimulate cell proliferation and promote G1/S phase transition through activation of target of rapamycin signaling pathway. The expression of myogenic regulatory factors, including myoD and follistatin , was upregulated, while that of myogenin and myostatin was downregulated by PA...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29773800/x-ray-structure-of-a-carpet-like-antimicrobial-defensin-phospholipid-membrane-disruption-complex
#4
Michael Järvå, Fung T Lay, Thanh Kha Phan, Cassandra Humble, Ivan K H Poon, Mark R Bleackley, Marilyn A Anderson, Mark D Hulett, Marc Kvansakul
Defensins are cationic antimicrobial peptides expressed throughout the plant and animal kingdoms as a first line of defense against pathogens. Membrane targeting and disruption is a crucial function of many defensins, however the precise mechanism remains unclear. Certain plant defensins form dimers that specifically bind the membrane phospholipids phosphatidic acid (PA) and phosphatidylinositol 4,5-bisphosphate, thereby triggering the assembly of defensin-lipid oligomers that permeabilize cell membranes. To understand this permeabilization mechanism, here we determine the crystal structure of the plant defensin NaD1 bound to PA...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29769200/long-chain-n-3-fatty-acids-attenuate-oncogenic-kras-driven-proliferation-by-altering-plasma-membrane-nanoscale-proteolipid-composition
#5
Natividad R Fuentes, Mohamed Mlih, Rola Barhoumi, Yang-Yi Fan, Paul Hardin, Trevor J Steele, Spencer Behmer, Ian A Prior, Jason Karpac, Robert S Chapkin
Ras signaling originates from transient nanoscale compartmentalized regions of the plasma membrane composed of specific proteins and lipids. The highly specific lipid composition of these nanodomains, termed nanoclusters, facilitates effector recruitment and therefore influences signal transduction. This suggests that Ras nanocluster proteolipid composition could represent a novel target for future chemoprevention interventions. There is evidence that consumption of fish oil containing long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) such as eicosapentaenoic acid (EPA, 20:5Δ5,8,11,14,17) and docosahexaenoic acid (DHA, 22:6Δ4,7,10,13,16,19) may reduce colon cancer risk in humans, yet the mechanism underlying this effect is unknown...
May 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29765047/tip60-mediated-lipin-1-acetylation-and-er-translocation-determine-triacylglycerol-synthesis-rate
#6
Terytty Yang Li, Lintao Song, Yu Sun, Jingyi Li, Cong Yi, Sin Man Lam, Dijin Xu, Linkang Zhou, Xiaotong Li, Ying Yang, Chen-Song Zhang, Changchuan Xie, Xi Huang, Guanghou Shui, Shu-Yong Lin, Karen Reue, Sheng-Cai Lin
Obesity is characterized by excessive fatty acid conversion to triacylglycerols (TAGs) in adipose tissues. However, how signaling networks sense fatty acids and connect to the stimulation of lipid synthesis remains elusive. Here, we show that homozygous knock-in mice carrying a point mutation at the Ser86 phosphorylation site of acetyltransferase Tip60 (Tip60 SA/SA ) display remarkably reduced body fat mass, and Tip60 SA/SA females fail to nurture pups to adulthood due to severely reduced milk TAGs. Mechanistically, fatty acids stimulate Tip60-dependent acetylation and endoplasmic reticulum translocation of phosphatidic acid phosphatase lipin 1 to generate diacylglycerol for TAG synthesis, which is repressed by deacetylase Sirt1...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29758358/lipidomic-signature-of-serum-from-the-rats-exposed-to-alcohol-for-one-year
#7
Hongchun Li, Wei Xu, Linhong Jiang, Hui Gu, Menglu Li, Jiamei Zhang, Wei Guo, Pengchi Deng, Hailei Long, Qian Bu, Jingwei Tian, Yinglan Zhao, Xiaobo Cen
Alcohol abuse and its related diseases are the major risk factors for human health. Although the mechanism of alcohol-related disorders has been widely investigated, serum metabolites associated with long-term alcohol intake have not been well explored. In this study, we aimed to investigate the profiles of serum metabolites and lipid species of rats chronically exposed to alcohol, which may be involved in the pathogenesis of alcohol-associated disease. An 1 H NMR-based metabolomics and Q-TOF/MS-based lipidomics approach were applied to investigate the profile of serum metabolites and lipid species of rats administrated daily with alcohol (12% vol/vol, 10 ml/kg per day, i...
May 11, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29757220/annexins-coordinators-of-cholesterol-homeostasis-in-endocytic-pathways
#8
REVIEW
Carles Rentero, Patricia Blanco-Muñoz, Elsa Meneses-Salas, Thomas Grewal, Carlos Enrich
The spatiotemporal regulation of calcium (Ca2+ ) storage in late endosomes (LE) and lysosomes (Lys) is increasingly recognized to influence a variety of membrane trafficking events, including endocytosis, exocytosis, and autophagy. Alterations in Ca2+ homeostasis within the LE/Lys compartment are implicated in human diseases, ranging from lysosomal storage diseases (LSDs) to neurodegeneration and cancer, and they correlate with changes in the membrane binding behaviour of Ca2+ -binding proteins. This also includes Annexins (AnxA), which is a family of Ca2+ -binding proteins participating in membrane traffic and tethering, microdomain organization, cytoskeleton interactions, Ca2+ signalling, and LE/Lys positioning...
May 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29754803/a-combinatorial-lipid-code-shapes-the-electrostatic-landscape-of-plant-endomembranes
#9
Matthieu Pierre Platre, Lise C Noack, Mehdi Doumane, Vincent Bayle, Mathilde Laetitia Audrey Simon, Lilly Maneta-Peyret, Laetitia Fouillen, Thomas Stanislas, Laia Armengot, Přemysl Pejchar, Marie-Cécile Caillaud, Martin Potocký, Alenka Čopič, Patrick Moreau, Yvon Jaillais
Membrane surface charge is critical for the transient, yet specific recruitment of proteins with polybasic regions to certain organelles. In eukaryotes, the plasma membrane (PM) is the most electronegative compartment of the cell, which specifies its identity. As such, membrane electrostatics is a central parameter in signaling, intracellular trafficking, and polarity. Here, we explore which are the lipids that control membrane electrostatics using plants as a model. We show that phosphatidylinositol-4-phosphate (PI4P), phosphatidic acidic (PA), and phosphatidylserine (PS) are separately required to generate the electrostatic signature of the plant PM...
May 8, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29754486/nanoparticle-wettability-influences-nanoparticle-phospholipid-interactions
#10
Nagarjun Konduru, Flavia Damiani, Svetla Stoilova-McPhie, Jason Tresback, Georgios Pyrgiotakis, Thomas C Donaghey, Philip Demokritou, Joseph Brain, Ramon M Molina
We explored the influence of nanoparticle (NP) surface charge and hydrophobicity on nanoparticle-biomolecule interactions by measuring the composition of adsorbed phospholipids on four NPs, namely positively charged CeO2 and ZnO, and negatively charged BaSO4 and silica-coated CeO2 after exposure to bronchoalveolar lavage fluid (BALf) obtained from rats, and to a mixture of neutral dipalmitoyl phosphatidylcholine (DPPC) and negatively charged dipalmitoyl phosphatidic acid (DPPA). The resulting NP-lipid interactions were examined by cryogenic transmission electron microscopy (cryo-TEM) and by atomic force microscopy (AFM)...
May 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29753473/dietary-linseed-supplementation-affects-the-fatty-acid-composition-of-the-sn-2-position-of-triglycerides-in-sheep-milk
#11
A Serra, G Conte, F Ciucci, E Bulleri, L Corrales-Retana, A Cappucci, A Buccioni, M Mele
In the human intestine, lipids are absorbed as sn-2 monoglycerides (sn-2, also named β-position), produced mainly by pancreatic lipases, which hydrolysate the triglyceride molecule in positions 1 and 3 (sn-1,3, α-position). The fatty acids esterified in sn-2 are thus preferentially absorbed, which means that the bioavailability of a single fatty acid is affected by its position on the triglyceride. This experiment is carried out with the milk used to make cheese applied in a study with 42 human volunteers...
May 9, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29748960/hrb2-and-bbx21-interaction-modulates-arabidopsis-abi5-locus-and-stomatal-aperture
#12
Xiaojun Kang, Gang Xu, Byungha Lee, Chen Chen, Huanan Zhang, Rui Kuang, Min Ni
Blue light triggers the opening of stomata in the morning to allow CO2 uptake and water loss through transpiration. During the day, plants may experience periodic drought and accumulate abscisic acid (ABA). ABA antagonizes blue light signaling through phosphatidic acid and reduces stomatal aperture. This study reveals a molecular mechanism by which two light signaling proteins interact to repress ABA signaling in the control of stomatal aperture. A hypersensitive to red and blue 2 (hrb2) mutant has a defective ATP-dependent chromatin-remodeling factor, PKL, in the chromodomain/helicase/DNA binding family...
May 10, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29748303/live-and-let-die-phosphatidic-acid-modulates-the-self-incompatibility-response
#13
Robert C Augustine
No abstract text is available yet for this article.
May 10, 2018: Plant Cell
https://www.readbyqxmd.com/read/29747431/turnover-of-glycerolipid-metabolite-pool-and-seed-viability
#14
Xiao-Long Hu, Xiao-Mei Yu, Hong-Ying Chen, Wei-Qi Li
Hydration⁻dehydration cycles can frequently cause stress to seeds, but can also be used to improve germination. However, the molecular basis of the stress caused is poorly understood. Herein, we examine the effects of hydration⁻dehydration cycles on seed viability and profile the membrane glycerolipid molecular species. We find that seed viability was not affected during the first two cycles, but significantly decreased as further cycles were applied, until all viability was lost. The abundances of seven glycerolipid classes increased and decreased through hydration and dehydration, respectively, but the phosphatidic acid and diacylglycerol abundances changed in the opposite sense, while total glycerolipid contents remained constant...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29729479/palmitate-lipotoxicity-in-enteric-glial-cells-lipid-remodeling-and-mitochondrial-ros-are-responsible-for-cyt-c-release-outside-mitochondria
#15
Lara Macchioni, Maya Petricciuolo, Magdalena Davidescu, Katia Fettucciari, Paolo Scarpelli, Rita Vitale, Leonardo Gatticchi, Pierluigi Orvietani, Andrea Marchegiani, Pierfrancesco Marconi, Gabrio Bassotti, Angela Corcelli, Lanfranco Corazzi
Enteric glial cells (EGCs) are components of the enteric nervous system, an organized structure that controls gut functions. EGCs may be vulnerable to different agents, such as bacterial infections that could alter the intestinal epithelial barrier, allowing bacterial toxins and/or other agents possessing intrinsic toxic effect to access cells. Palmitate, known to exhibit lipotoxicity, is released in the gut during the digestion process. In this study, we investigated the lipotoxic effect of palmitate in cultured EGCs, with particular emphasis on palmitate-dependent intracellular lipid remodeling...
May 2, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29717024/a-phosphatidic-acid-binding-protein-is-important-for-lipid-homeostasis-and-adaptation-to-anaerobic-biofilm-conditions-in-pseudomonas-aeruginosa
#16
Maike K Groenewold, Marco Massmig, Stefanie Hebecker, Linna Danne, Zofia Magnowska, Manfred Nimtz, Franz Narberhaus, Dieter Jahn, Dirk W Heinz, Lothar Jänsch, Jürgen Moser
A quantitative Pseudomonas aeruginosa proteomics approach revealed increased abundance of the so far uncharacterized protein PA3911 in anaerobic biofilms grown under conditions of the cystic fibrosis lung. Physiological relevance of ORF PA3911 was demonstrated, inter alia , using phenotype microarray experiments. The mutant strain showed increased susceptibility in the presence of antimicrobials (minocycline, nafcillin, oxacillin, chloramphenicol, thiamphenicol), enhanced twitching motility and significantly impaired biofilm formation...
May 1, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29717019/floury-shrunken-endosperm1-connects-phospholipid-metabolism-and-amyloplast-development-in-rice
#17
Wuhua Long, Yunlong Wang, Susong Zhu, Wen Jing, Yihua Wang, Yulong Ren, Yunlu Tian, Shijia Liu, Xi Liu, Liangming Chen, Di Wang, Mingsheng Zhong, Yuanyan Zhang, Tingting Hu, Jianping Zhu, Yuanyuan Hao, Xiaopin Zhu, Wenwei Zhang, Chunming Wang, Wenhua Zhang, Jianmin Wan
Starch synthesized and stored in amyloplasts serves as the major energy storage molecule in cereal endosperm. To elucidate the molecular mechanisms underlying amyloplast development and starch synthesis, we isolated a series of floury endosperm mutants in rice (Oryza sativa L.). We identified the rice mutant floury shrunken endosperm1 (fse1), which exhibited obvious defects in the development of compound starch grains, decreased starch content, and altered starch physicochemical features. Map-based cloning showed that FSE1 encodes a phospholipase-like protein homologous to phosphatidic acid-preferring phospholipase A1...
May 1, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29716992/phosphatidic-acid-counteracts-s-rnase-signaling-in-pollen-by-stabilizing-the-actin-cytoskeleton
#18
Jianqing Chen, Peng Wang, Barend H J de Graaf, Hao Zhang, Huijun Jiao, Chao Tang, Shaoling Zhang, Juyou Wu
S-RNase is the female determinant of self-incompatibility (SI) in pear (Pyrus bretschneideri). After translocation to the pollen tube, S-RNase degrades rRNA and induces pollen tube death in an S-haplotype-specific manner. In this study, we found that the actin cytoskeleton is a target of P. bretschneideri S-RNase (PbrS-RNase) and uncovered a mechanism that involves phosphatidic acid (PA) and protects the pollen tube from PbrS-RNase cytotoxicity. PbrS-RNase interacts directly with PbrActin1 in an S-haplotype-independent manner, causing the actin cytoskeleton to depolymerize and promoting programmed cell death in the self-incompatible pollen tube...
April 30, 2018: Plant Cell
https://www.readbyqxmd.com/read/29709941/a-case-of-miller-fisher-syndrome-mimicking-tolosa-hunt-syndrome
#19
Masahiro Oomura, Yuto Uchida, Keita Sakurai, Takanari Toyoda, Kenji Okita, Noriyuki Matsukawa
We herein report a patient with Miller Fisher syndrome mimicking Tolosa-Hunt syndrome. A 47-year-old man presented with right orbital pain and diplopia. On a neurological examination, he had right oculomotor nerve palsy and diminished deep tendon reflexes. Brain magnetic resonance imaging failed to show any parenchymal lesions; however, the bilateral oculomotor nerves were gadolinium-enhanced. The presence of a triad of orbital pain, ipsilateral oculomotor nerve palsy, and a rapid response to steroid therapy met the diagnostic criteria for Tolosa-Hunt syndrome...
April 27, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29703186/hpv-16-e7-expression-up-regulates-phospholipase-d-activity-and-promotes-rapamycin-resistance-in-a-prb-dependent-manner
#20
Tatiana Rabachini, Enrique Boccardo, Rubiana Andrade, Katia Regina Perez, Suely Nonogaki, Iolanda Midea Cuccovia, Luisa Lina Villa
BACKGROUND: Human Papillomavirus (HPV) infection is the main risk factor for the development and progression of cervical cancer. HPV-16 E6 and E7 expression is essential for induction and maintenance of the transformed phenotype. These oncoproteins interfere with the function of several intracellular proteins, including those controlling the PI3K/AKT/mTOR pathway in which Phospolipase D (PLD) and Phosphatidic acid (PA) play a critical role. METHODS: PLD activity was measured in primary human keratinocytes transduced with retroviruses expressing HPV-16 E6, E7 or E7 mutants...
April 27, 2018: BMC Cancer
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