keyword
https://read.qxmd.com/read/33022388/investigation-of-transfollicular-caffeine-penetration-using-microdialysis-on-ex-vivo-porcine-ear-skin
#21
JOURNAL ARTICLE
Anna Lena Klein, Markus Lubda, Per Stahl Skov, Annika Vogt, Cornelia M Keck, Jürgen Lademann, Ingeborg Beckers, Jörg von Hagen, Alexa Patzelt
The aim of this study was to develop an ex vivo method that allows to quantify the transfollicular penetration of topically applied substances by combining microdialysis and selective follicular closure with varnish. An experimental setup with three skin areas on ex vivo intact porcine ear skin was designed (varnish on hair follicle, varnish next to hair follicle, no varnish). On each area, 10 µl/cm2 caffeine-hydroxyethyl-cellulose-gel was applied. Samples were collected for 22h by microdialysis. After sampling, the skin layers were separated, homogenized and caffeine was quantified by high pressure liquid chromatography (HPLC) in all samples...
October 3, 2020: European Journal of Pharmaceutics and Biopharmaceutics
https://read.qxmd.com/read/33022196/caffeine-in-hair-care-and-anticellulite-cosmetics-sample-preparation-solid-phase-extraction-and-hplc-determination
#22
JOURNAL ARTICLE
Kristina Mladenov, Slavica SunariĆ
Caffeine is extensively used in cellulite and hair growth cosmetic products. Regulations in the field of cosmetics require manufacturers to list caffeine in the ingredient list on product labels, but its exact content in these products is not declared. On the other hand, daily exposure to caffeine from all sources may approach health reference values. For that reason, it is important to know the exact caffeine content in products for skin and hair care. Cosmetics are often viscous or semisolid products of very complex chemical composition...
2020: Journal of Cosmetic Science
https://read.qxmd.com/read/32879223/effect-of-rubbing-on-the-distribution-of-topically-applied-drugs-into-the-hair-follicles
#23
JOURNAL ARTICLE
Akinari Abe, Hiromichi Suzuki, Miyuki Saito, Hiroaki Todo, Kenji Sugibayashi
Rubbing actions are often conducted to apply topical formulations onto the skin. Although rubbing was found to increase the skin permeation of drugs, few reports have revealed whether rubbing enhanced either drug permeation through the stratum corneum (SC) or hair follicles (HFs) pathways, or through both. In the present study, we investigated the effects of rubbing on caffeine (CAF) distribution in the SC and HFs. The effect of rubbing direction on the skin penetration of CAF was also investigated. The skin concentration of CAF and its cumulative permeation amount were increased clearly by rubbing...
2020: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/32740912/caffeine-relaxes-hair-follicles-in-androgenetic-alopecia
#24
COMMENT
M Ohyama
No abstract text is available yet for this article.
January 2021: British Journal of Dermatology
https://read.qxmd.com/read/32607303/telogen-effluvium-a-review-of-the-literature
#25
REVIEW
Fahham Asghar, Nazia Shamim, Umar Farooque, Haris Sheikh, Ramsha Aqeel
Telogen effluvium is one of the most common causes of alopecia. It is a scalp disorder characterized by excessive shedding of hair. Several factors such as drugs, trauma, and emotional and physiological stress can lead to the development of telogen effluvium. Multiple alterations in the hair cycle have been proposed as the underlying mechanism. Telogen effluvium can present as acute or chronic hair fall with symptoms such as trichodynia. Diagnostic tests that can be used include hair wash test, trichogram, phototrichogram, and scalp biopsy...
May 27, 2020: Curēus
https://read.qxmd.com/read/32599587/caffeine-and-its-pharmacological-benefits-in-the-management-of-androgenetic-alopecia-a-review
#26
REVIEW
Jörn Michael Völker, Nadine Koch, Maike Becker, Adolf Klenk
Caffeine, particularly after ingestion, is well known to exert various pharmacological effects. A growing body of evidence implicates the ingestion of caffeine with beneficial effects on several diseases. The easy penetration of caffeine across the skin barrier and into human skin makes caffeine an ideal compound for topical application. Hair loss is known to negatively affect the quality of life and predispose to depression and anxiety. Androgenetic alopecia (AGA) is the most common type of hair loss in both men and women...
2020: Skin Pharmacology and Physiology
https://read.qxmd.com/read/32271938/new-effects-of-caffeine-on-corticotropin-releasing-hormone-crh-induced-stress-along-the-intrafollicular-classical-hypothalamic-pituitary-adrenal-hpa-axis-crh-r1-2-ip-3-r-acth-mc-r2-and-the-neurogenic-non-hpa-axis-substance-p-p75-ntr-and-trka-in-ex%C3%A2-vivo-human
#27
JOURNAL ARTICLE
T W Fischer, A Bergmann, N Kruse, K Kleszczynski, C Skobowiat, A T Slominski, R Paus
BACKGROUND: Human hair is highly responsive to stress, and human scalp hair follicles (HFs) contain a peripheral neuroendocrine equivalent of the systemic hypothalamic-pituitary-adrenal (HPA) stress axis. Androgenetic alopecia (AGA) is supposed to be aggravated by stress. We used corticotropin-releasing hormone (CRH), which triggers the HPA axis, to induce a stress response in human ex vivo male AGA HFs. Caffeine is known to reverse testosterone-mediated hair growth inhibition in the same hair organ culture model...
January 2021: British Journal of Dermatology
https://read.qxmd.com/read/32246261/caffeine-content-in-newborn-hair-correlates-with-maternal-dietary-intake
#28
JOURNAL ARTICLE
Anni Lehtonen, Lauri Uusitalo, Seppo Auriola, Katri Backman, Seppo Heinonen, Leea Keski-Nisula, Markku Pasanen, Juha Pekkanen, Tomi-Pekka Tuomainen, Raimo Voutilainen, Sari Hantunen, Marko Lehtonen
PURPOSE: High-maternal caffeine intake during pregnancy may be harmful for perinatal outcomes and future child health, but the level of fetal cumulative exposure has been difficult to measure thus far. Here, we present maternal dietary caffeine intake during the last trimester and its correlation to caffeine content in newborn hair after birth. METHODS: Maternal third trimester diets and dietary caffeine intake were prospectively collected in Kuopio Birth Cohort (KuBiCo) using a 160-item food frequency questionnaire (n = 2840)...
April 3, 2020: European Journal of Nutrition
https://read.qxmd.com/read/32045923/solvent-containing-closure-material-can-be-used-to-prevent-follicular-penetration-of-caffeine-and-fluorescein-sodium-salt-on-porcine-ear-skin
#29
JOURNAL ARTICLE
Anna Lena Klein, Markus Lubda, Paniz Akbarzadeh Taghavi, Jürgen Lademann, Ingeborg Beckers, Jörg von Hagen, Harald Kolmar, Alexa Patzelt
AIM: The skin represents a drug delivery portal. The establishment of a skin model capable of distinguishing between the follicular and intercellular penetration pathways remains a challenge. The study described herein was aimed at showing the influence of two nail varnishes as closure material and four application techniques to spread the active pharmaceutical ingredient (API) on a successful follicular closure without inducing penetration-enhancing effects. MATERIALS AND METHODS: For all experiments, ex vivo porcine ear skin was used...
February 11, 2020: Skin Pharmacology and Physiology
https://read.qxmd.com/read/32023218/clinical-efficacy-of-a-topical-compounded-formulation-in-male-androgenetic-alopecia-minoxidil-10-finasteride-0-1-biotin-0-2-and-caffeine-citrate-0-05-hydroalcoholic-solution
#30
JOURNAL ARTICLE
James C Marotta, Gopesh Patel, Maria Carvalho, Samantha Blakeney
Androgenetic alopecia is the most common form of hair loss. This condition affects both men and women causing significant psychological distress and a decrease in the quality of life. The objective of this study was to investigate the clinical efficacy and patient satisfaction of a topical compounded formulation (minoxidil 10%, finasteride 0.1%, biotin 0.2%, and caffeine citrate 0.05% hydroalcoholic solution) in male androgenetic alopecia patients. A total of five individual, prospective case studies were conducted in the private hair transplant practice of Dr...
2020: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/31267026/oral-administration-of-caffeine-exacerbates-cisplatin-induced-hearing-loss
#31
JOURNAL ARTICLE
Sandeep Sheth, Kelly Sheehan, Asmita Dhukhwa, Raheem F H Al Aameri, Chaitanya Mamillapalli, Debashree Mukherjea, Leonard P Rybak, Vickram Ramkumar
Adenosine A1 receptors (A1 AR) are well characterized for their role in cytoprotection. Previous studies have demonstrated the presence of these receptors in the cochlea where their activation were shown to suppress cisplatin-induced inflammatory response and the resulting ototoxicity. Inhibition of A1 AR by caffeine, a widely consumed psychoactive substance, could antagonize the endogenous protective role of these receptors in cochlea and potentiate cisplatin-induced hearing loss. This hypothesis was tested in a rat model of cisplatin ototoxicity following oral administration of caffeine...
July 2, 2019: Scientific Reports
https://read.qxmd.com/read/30935254/the-use-of-phosphodiesterase-inhibitors-for-the-treatment-of-alopecia
#32
REVIEW
Margit L W Juhász, Natasha Atanaskova Mesinkovska
Background: Hair loss encompasses a group of scarring and nonscarring diseases with limited treatment options. Understanding the pathogenesis of alopecias has led to the experimental use of phosphodiesterase inhibitors (PDEi). Objective: To perform a systematic review of literature surrounding the use of PDEi for alopecia. Materials and methods: A search was conducted using PubMed in February 2019 on PDEi and alopecia. Inclusion criteria were clinical trials, prospective or retrospective studies, case series and case reports written in English, using PDEi in human subjects for the treatment of alopecia...
May 2020: Journal of Dermatological Treatment
https://read.qxmd.com/read/30746733/uv-radiation-on-scalp-skin-surface-induces-scalp-hair-follicle-damage-ex-vivo-and-is-alleviated-by-the-topical-treatment-with-caffeine
#33
JOURNAL ARTICLE
Jennifer Gherardini, Jeannine Wegner, Jérémy Chéret, Sushmita Ghatak, Janin Lehmann, Majid Alam, Francisco Jimenez, Wolfgang Funk, Markus Böhm, Natalia Botchkareva, Chris Ward, Ralf Paus, Marta Bertolini
OBJECTIVES: While the effect of ultraviolet radiation (UVR) on human skin has been extensively studied, very little is known on how UVR impacts on hair follicle (HF) homeostasis. Here, we investigated how solar spectrum UVR that hits the human skin surface impacts on HF biology, and whether any detrimental effects can be mitigated by a widely used cosmetic and nutraceutical ingredient, caffeine. METHODS: Human scalp skin with terminal HFs was irradiated transepidermally ex vivo using either 10 J/cm2 UVA (340-440 nm) + 20 mJ/cm2 UVB (290-320 nm) (low dose) or 50 J/cm2 UVA + 50 mJ/cm2 UVB (high dose) and organ-cultured under serum-free conditions for 1 or 3 days...
February 11, 2019: International Journal of Cosmetic Science
https://read.qxmd.com/read/30682464/management-of-symptom-flares-and-patient-reported-flare-triggers-in-interstitial-cystitis-bladder-pain-syndrome-ic-bps-findings-from-one-site-of-the-mapp-research-network
#34
JOURNAL ARTICLE
H Henry Lai, Joel Vetter, Joseph Song, Gerald L Andriole, Graham A Colditz, Siobhan Sutcliffe
OBJECTIVE: To document patient-reported interstitial cystitis/bladder pain syndrome (IC/BPS) flare management strategies and triggers. MATERIALS AND METHODS: Twenty-four male and 29 female participants enrolled at the Washington University site of the MAPP Research Network completed a questionnaire on strategies they utilized to manage flares and factors they believed triggered their flares (eg, specific food items, physical activities, sexual activities, infections, and stress)...
April 2019: Urology
https://read.qxmd.com/read/30247550/biomonitoring-an-albumin-adduct-of-the-cooked-meat-carcinogen-2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine-in-humans
#35
JOURNAL ARTICLE
Medjda Bellamri, Yi Wang, Kim Yonemori, Kami K White, Lynne R Wilkens, Loïc Le Marchand, Robert J Turesky
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed in cooked meats and may be linked to dietary associated colorectal, prostate, and mammary cancers. Genotoxic N-oxidized metabolites of PhIP react with the Cys 34 of albumin (Alb) to form a sulfinamide adduct, a biomarker of the biologically effective dose. We examined the kinetics of PhIP-Alb adduct formation in plasma of volunteers on a 4-week semi-controlled diet of cooked meat containing known quantities of PhIP. The adduct was below the limit of detection (LOD) (10 femtograms PhIP/mg Alb) in most subjects before the meat feeding, but increased by up to 560-fold at week four in subjects who ate meat containing 8...
September 21, 2018: Carcinogenesis
https://read.qxmd.com/read/30081258/the-influence-of-caffeine-on-ethyl-glucuronide-levels-in-rat-serum-and-in-rat-hair
#36
JOURNAL ARTICLE
Anna Małkowska, Magdalena Bamburowicz-Klimkowska, Marcin Łukasik, Krzysztof Grucza, Mirosław Szutowski, Dorota Kwiatkowska
BACKGROUND: Ethanol and caffeine are the most widely used psychoactive substances in the world, with an observed steady increase in the combined consumption of alcohol and caffeine. Specific signs of ethanol-caffeine interactions have been reported both in humans and in animals. The metabolic effects of these interactions have not been fully elucidated. There are no published reports on the influence of caffeine on ethyl glucuronide (EtG) formation. EtG is a direct metabolite of ethanol and is very often used as a biomarker of alcohol consumption...
October 2018: Pharmacological Reports: PR
https://read.qxmd.com/read/30057663/androgenetic-alopecia-treatment-in-asian-men
#37
JOURNAL ARTICLE
Yohei Tanaka, Toru Aso, Jumpei Ono, Ryu Hosoi, Takuto Kaneko
Background: Androgenetic alopecia (AGA) is a common form of hair loss in Asian men. Although AGA is often regarded as a relatively minor dermatological condition, hair loss can impact self-image and is a main cause for anxiety and depression in some men. We have treated patients with AGA for seven years. Objective: The goal of this study was to evaluate the effectiveness of our combination therapy in Asian men with AGA. Participants: Between the years 2011 and 2017, 18,918 male patients were treated in our center...
July 2018: Journal of Clinical and Aesthetic Dermatology
https://read.qxmd.com/read/30001555/follicular-penetration-of-caffeine-from-topically-applied-nanoemulsion-formulations-containing-penetration-enhancers-in-vitro-human-skin-studies
#38
JOURNAL ARTICLE
Eman Abd, Heather A E Benson, Michael S Roberts, Jeffrey E Grice
BACKGROUND/AIMS: This study aimed to investigate transfollicular delivery enhancement of caffeine from nanoemulsion formulations incorporating oleic acid (OA) and eucalyptol (EU) as chemical penetration enhancers. METHODS: Caffeine permeation was evaluated from nanoemulsions containing OA or EU and an aqueous control solution through excised human full-thickness skin with hair follicles opened, blocked, or left untreated. Differential tape stripping was performed, followed by cyanoacrylate skin surface biopsies to determine the amount of caffeine in the hair follicles, and skin extraction to determine the retention of caffeine in the skin...
2018: Skin Pharmacology and Physiology
https://read.qxmd.com/read/29512972/efficacy-of-a-cosmetic-phyto-caffeine-shampoo-in-female-androgenetic-alopecia
#39
RANDOMIZED CONTROLLED TRIAL
Carolina Bussoletti, Maria V Tolaini, Leonardo Celleno
BACKGROUND: Androgenetic alopecia (AGA) is the most common type of hair loss in both males as well as females, occurring in up to 57% of women by the age of 80 years. Androgenetic alopecia is associated with a high psychological burden and often results in substantially reduced quality of life, poor body image and low self-esteem, particularly in women. Caffeine-based products have shown promise, both in vitro and in vivo, as potential treatments for AGA. This study was performed to determine the efficacy of a phyto-caffeine-containing shampoo used over a 6-month period in female subjects with AGA...
August 2020: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://read.qxmd.com/read/29471145/establishment-of-an-evaluation-method-to-detect-drug-distribution-in-hair-follicles
#40
JOURNAL ARTICLE
Akinari Abe, Miyuki Saito, Wesam R Kadhum, Hiroaki Todo, Kenji Sugibayashi
Development of an appropriate method to evaluate drug disposition or targeting ability in hair follicles (HFs) is urgently needed in order to develop useful pharmaceutical products with pharmacological effects in HFs. In the present study, a cyanoacrylate biopsy (CB) method was used to measure drug disposition in HFs using a model hydrophilic drug, caffeine (CAF), and a lipophilic drug, 4-butylresorcinol (BR), in excised porcine skin. As a result, the height of HF replicas and the recovery ratio decreased with an increase in the application times of the CB method...
May 5, 2018: International Journal of Pharmaceutics
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