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JOURNAL ARTICLE
Zakhar V Reveguk, Evgeny V Khoroshilov, Andrey V Sharkov, Vladimir A Pomogaev, Andrey A Buglak, Alexei I Kononov
We have studied the excited states and structural properties for the complexes of cytosine (dC)10 chains with silver ions (Ag+ ) in a wide range of the Ag+ to DNA ratio ( r ) and pH conditions using circular dichroism, steady-state absorption, and fluorescence spectroscopy along with the ultrafast fluorescence upconversion technique. We also calculated vertical electronic transition energies and determined the nature of the corresponding excited states in some models of the cytosine-Ag+ complexes. We show that (dC)10 chains in the presence of silver ions form a duplex stabilized by C-Ag+ -C bonds...
April 24, 2024: Journal of Physical Chemistry. B
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JOURNAL ARTICLE
Liang Ma, Youyou Fang, Ni Yang, Ning Li, Lai Chen, Duanyun Cao, Yun Lu, Qing Huang, Tinglu Song, Yuefeng Su, Feng Wu
The poor bulk-phase and interphase stability, attributable to adverse internal stress, impede the cycling performance of silicon microparticles (μSi) anodes and its commercial application for high-energy-density lithium-ion batteries. In this work, we propose a groundbreaking gradient-hierarchically ordered conductive (GHOC) network structure, ingeniously engineered to enhance the stability of both bulk-phase and the solid electrolyte interphase (SEI) configurations of μSi. Within the GHOC network architecture, two-dimensional transition metal carbides (Ti3 C2 Tx ) acts as a conductive "brick", establishing a highly conductive inner layer on μSi, while the porous outer layer, composed of one-dimensional Tempo-oxidized cellulose nanofibers (TCNF) and polyacrylic acid (PAA) macromolecule, functions akin to structural "rebar" and "concrete", effectively preserves the tightly interconnected conductive framework though multiple bonding mechanisms, including covalent and hydrogen bonds...
April 24, 2024: Advanced Materials
#23
JOURNAL ARTICLE
Keiji Komatsu, Takanori Matsuura, Takahiro Ogawa
PURPOSE: The formation of a biological seal between implant abutments and the surrounding soft tissue is a preventive strategy against peri-implantitis. The aim of this study is to test the hypothesis that surfaces of prosthetic implant abutments treated with vacuum ultraviolet (VUV) light enhance the growth and function of human gingival fibroblasts. MATERIALS AND METHODS: Implant abutments were treated with 172 nm VUV light for one minute. Untreated abutments were subjected as controls...
April 24, 2024: International Journal of Oral & Maxillofacial Implants
#24
JOURNAL ARTICLE
Karla T Washington, Charlton A Mechling, Kyle A Pitzer, Samuel Maiser, Ambereen K Mehta
Introduction/Aims: This national survey builds on previous qualitative research examining potential palliative care needs among people living with ALS (pALS) by quantifying and investigating relationships among pALS' stage of illness progression; physical, emotional, social, spiritual, and intimacy-related concerns; advance care planning behaviors; perceptions of feeling heard and understood by healthcare providers; and overall quality of life. Methods: Researchers partnered with national organizations to recruit pALS to participate in a one-time survey comprising items from validated instruments (eg, the ALS Specific Quality of Life Instrument-Revised) and researcher-generated measures...
April 24, 2024: American Journal of Hospice & Palliative Care
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JOURNAL ARTICLE
Mohammad Abdolsamadi, Sharareh Rasouli, Ali Alizadeh Severi, Mohammad Reza Khirehgesh, Fatemeh Safari, Nejat Mahdieh, Habibolah Khazaie, Bijan Soleymani, Bahman Akbari
Introduction: Sleep is one of the most significant parts of everyone's life. Most people sleep for about one-third of their lives. Sleep disorders negatively impact the quality of life. Obstructive sleep apnea (OSA) is a severe sleep disorder that significantly impacts the patient's life and their family members. This study aimed to investigate the relationship between rs6313 and rs6311 polymorphisms in the serotonin receptor type 2A gene and OSA in the Kurdish population. Materials and Methods: The study's population comprises 100 OSA sufferers and 100 healthy people...
April 2024: Genetic Testing and Molecular Biomarkers
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JOURNAL ARTICLE
Somayya Naguib, Lamiaa A Mansour, Neveen A Soliman, Hadeel M El-Hanafy, Yosra A Fahmy, Mohamed A Elmonem, Radwa M Abdel Halim
Introduction: Approximately 80% of primary hyperoxaluria cases are caused by primary hyperoxaluria type 1 (PH1, OMIM# 259900), which is characterized by pathogenic variants in the AGXT gene, resulting in deficiency of the liver-specific enzyme alanine-glyoxylate aminotransferase (AGT). This leads to increased production of oxalate, which cannot be effectively eliminated from the body, resulting in its accumulation primarily in the kidneys and other organs. Subjects and Methods: This study included 17 PH1 Egyptian patients from 12 unrelated families, recruited from the Inherited Kidney Disease Outpatient Clinic and the Dialysis Units, Cairo University Hospitals, during the period from January 2018 to December 2019, aiming to identify the pathogenic variants in the AGXT gene...
April 2024: Genetic Testing and Molecular Biomarkers
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JOURNAL ARTICLE
Jing Wang, He-Kang Ding, Han-Jiang Xu, De-Kai Hu, William Hankey, Li Chen, Jun Xiao, Chao-Zhao Liang, Bing Zhao, Ling-Fan Xu
Tumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stromal cells...
April 23, 2024: Asian Journal of Andrology
#28
JOURNAL ARTICLE
Sheng Yang, Dongsheng Zhang, Qingyang Sun, Hongxu Nie, Yue Zhang, Xiaowei Wang, Yuanjian Huang, Yueming Sun
Colorectal cancer (CRC) is one of the most common malignant tumors in humans, with liver metastasis being the primary cause of mortality. The epithelial-mesenchymal transition (EMT) process endows cancer cells with enhanced metastatic potential. To elucidate the cellular mechanisms driving EMT in CRC, we analyzed single-cell RNA-sequencing (scRNA-seq) data from 11 non-metastatic primary tumors (TnM) and 11 metastatic primary tumors (TM) from CRC patients. Compared to TnM group, the TM samples showed elevated numbers of malignant epithelial cell and cancer-associated fibroblast (CAF) subsets that displayed enrichments of EMT, angiogenesis, and TGF-β signaling pathways...
April 24, 2024: Cancer Research
#29
JOURNAL ARTICLE
Danzhou Fang, Zhiming Zhou, Yalan Xiong, Yongzeng Fan, Yixuan Li, Huayi Zhao, Jiahui Huang, Gengbiao Yuan, Maohua Rao
OBJECTIVE: Alzheimer's disease, an irreversible neurological condition, demands timely diagnosis for effective clinical intervention. This study employs radiomics analysis to assess image features in default mode network cerebral perfusion imaging among individuals with cognitive impairment. METHODS: A radiomics analysis of cerebral perfusion imaging was conducted on 117 patients with cognitive impairment. They were divided into training and validation sets in a 7:3 ratio...
April 24, 2024: Journal of Applied Clinical Medical Physics
#30
JOURNAL ARTICLE
Yuta Ito, Amira Marouf, Yasunori Kogure, Junji Koya, Raphaël Liévin, Julie Bruneau, Mariko Tabata, Yuki Saito, Sumito Shingaki, Mitsuhiro Yuasa, Kentaro Yamaguchi, Koichi Murakami, Robert Weil, Manon Vavasseur, Guillaume P Andrieu, Mehdi Latiri, Layla Veleanu, Michaël Dussiot, Isabelle André, Akshay Joshi, Chantal Lagresle-Peyrou, Aude Magerus, Sammara Chaubard, David Lavergne, Emmanuel Bachy, Erika Brunet, Virginie Fataccioli, Chantal Brouzes, Camille Laurent, Laurence De Leval, Alexandra Traverse-Glehen, Céline Bossard, Marie-Cécile Parrens, Véronique Meignin, Laure Philippe, Julien Rossignol, Felipe Suarez, Jean-Marie Michot, Olivier Tournilhac, Gandhi Damaj, François Lemonnier, Christine Bôle-Feysot, Patrick Nitschké, Bruno Tesson, Cécile Laurent, Thierry Molina, Vahid Asnafi, Yosaku Watatani, Kenichi Chiba, Ai Okada, Yuichi Shiraishi, Sachiko Tsukita, Koji Izutsu, Hiroaki Miyoshi, Koichi Ohshima, Seiji Sakata, Akito Dobashi, Kengo Takeuchi, Masashi Sanada, Philippe Gaulard, Arnaud Jaccard, Seishi Ogawa, Olivier Hermine, Keisuke Kataoka, Lucile Couronné
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient stratification and treatments. Here, we performed comprehensive genetic analysis of 177 ENKTCL cases to delineate the landscape of mutations, copy number alterations (CNAs), and structural variations, identifying 34 driver genes including six previously unappreciated ones, namely HLA-B, HLA-C, ROBO1, CD58, POT1, and MAP2K1...
April 24, 2024: Cancer Research
#31
REVIEW
Robin R Murphy
The plot of the 2014 science-fiction movie Young Ones revolves around a robot pack mule based on the real-world BigDog.
April 24, 2024: Science Robotics
#32
JOURNAL ARTICLE
Nora E Rosenberg, Bonnie E Shook-Sa, Amber M Young, Yating Zou, Lynda Stranix-Chibanda, Marcel Yotebieng, Nadia A Sam-Agudu, Sam J Phiri, Wilbroad Mutale, Linda-Gail Bekker, Manhattan E Charurat, Sizulu Moyo, Khangelani Zuma, Jessica Justman, Michael G Hudgens, Benjamin H Chi
BACKGROUND: Women in Africa disproportionately acquire HIV-1. Understanding which women are most likely to acquire HIV-1 can guide focused prevention with pre-exposure prophylaxis (PrEP). Our objective is to identify women at highest risk of HIV-1 and estimate PrEP efficiency at different sensitivity levels. METHODS: Nationally representative data were collected from 2015-2019 from 15 population-based household surveys. This analysis included women aged 15-49 who tested HIV-1 sero-negative or had recent HIV-1...
April 24, 2024: Clinical Infectious Diseases
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JOURNAL ARTICLE
Betty Mwesigwa, Fredrick Sawe, Janet Oyieko, Joel Mwakisisile, Edna Viegas, Gideon Akindiran Akintunde, Josphat Kosgei, Afoke Kokogho, Nyanda Ntinginya, Ilesh Jani, Georgi Shukarev, Jay W Hooper, Steven A Kwilas, Lucy A Ward, Janice Rusnak, Callie Bounds, Rachel Overman, Christopher S Badorrek, Leigh Anne Eller, Michael A Eller, Christina S Polyak, Amber Moodley, Chi L Tran, Margaret C Costanzo, David J Leggat, Dominic Paquin-Proulx, Prossy Naluyima, Dickson Nkafu Anumendem, Auguste Gaddah, Kerstin Luhn, Jenny Hendriks, Chelsea McLean, Macaya Douoguih, Hannah Kibuuka, Merlin L Robb, Cynthia Robinson, Julie A Ake
BACKGROUND: Shorter prophylactic vaccine schedules may offer more rapid protection against Ebola in resource-limited settings. METHODS: This randomized, observer-blind, placebo-controlled, phase 2 trial conducted in five sub-Saharan African countries included people without HIV (PWOH, n = 249) and people living with HIV (PLWH, n = 250). Adult participants received one of two accelerated Ebola vaccine regimens (MVA-BN-Filo, Ad26.ZEBOV administered 14 days apart [n = 79] or Ad26...
April 24, 2024: Clinical Infectious Diseases
#34
JOURNAL ARTICLE
J Lesley Brown, Liangliang Zhang, Pedro P Rocha, Judith A Kassis, Ming-An Sun
Polycomb group (PcG) proteins mediate epigenetic silencing of important developmental genes by modifying histones and compacting chromatin through two major protein complexes, PRC1 and PRC2. These complexes are recruited to DNA by CpG islands (CGIs) in mammals and Polycomb response elements (PREs) in Drosophila . When PcG target genes are turned OFF, PcG proteins bind to PREs or CGIs, and PREs serve as anchors that loop together and stabilize gene silencing. Here, we address which PcG proteins bind to PREs and whether PREs mediate looping when their targets are in the ON transcriptional state...
April 26, 2024: Science Advances
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JOURNAL ARTICLE
Hyosim Yang, Gangseon Ji, Min Choi, Seondo Park, Hyeonjun An, Hyoung-Taek Lee, Joonwoo Jeong, Yun Daniel Park, Kyungwan Kim, Noejung Park, Jeeyoon Jeong, Dai-Sik Kim, Hyeong-Ryeol Park
Nanoconfined waters exhibit low static permittivity mainly due to interfacial effects that span about one nanometer. The characteristic length scale may be much longer in the terahertz (THz) regime where long-range collective dynamics occur; however, the THz dynamics have been largely unexplored because of the lack of a robust platform. Here, we use metallic loop nanogaps to sharply enhance light-matter interactions and precisely measure real and imaginary THz refractive indices of nanoconfined water at gap widths ranging from 2 to 20 nanometers, spanning mostly interfacial waters all the way to quasi-bulk waters...
April 26, 2024: Science Advances
#36
JOURNAL ARTICLE
Qing-Ling Hu, Ji-Chong Zhuo, Gang-Qi Fang, Jia-Bao Lu, Yu-Xuan Ye, Dan-Ting Li, Yi-Han Lou, Xiao-Ya Zhang, Xuan Chen, Si-Liang Wang, Zhe-Chao Wang, Yi-Xiang Zhang, Norida Mazlan, San San Oo, Thet Thet, Prem Nidhi Sharma, Jauharlina Jauharlina, Ir Henik Sukorini, Michael T Ibisate, S M Mizanur Rahman, Naved Ahmad Ansari, Ai-Dong Chen, Zeng-Rong Zhu, Kong Luen Heong, Gang Lu, Hai-Jian Huang, Jun-Min Li, Jian-Ping Chen, Shuai Zhan, Chuan-Xi Zhang
Many insect pests, including the brown planthopper (BPH), undergo windborne migration that is challenging to observe and track. It remains controversial about their migration patterns and largely unknown regarding the underlying genetic basis. By analyzing 360 whole genomes from around the globe, we clarify the genetic sources of worldwide BPHs and illuminate a landscape of BPH migration showing that East Asian populations perform closed-circuit journeys between Indochina and the Far East, while populations of Malay Archipelago and South Asia undergo one-way migration to Indochina...
April 26, 2024: Science Advances
#37
JOURNAL ARTICLE
Ellis L Torrance, Corey Burton, Awa Diop, Louis-Marie Bobay
Bacteria are nonsexual organisms but are capable of exchanging DNA at diverse degrees through homologous recombination. Intriguingly, the rates of recombination vary immensely across lineages where some species have been described as purely clonal and others as "quasi-sexual." However, estimating recombination rates has proven a difficult endeavor and estimates often vary substantially across studies. It is unclear whether these variations reflect natural variations across populations or are due to differences in methodologies...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#38
JOURNAL ARTICLE
Lauren Cooper, Marigold Gil Malinao, Guosong Hong
ConspectusTechnologies for neuromodulation have rapidly developed in the past decade with a particular emphasis on creating noninvasive tools with high spatial and temporal precision. The existence of such tools is critical in the advancement of our understanding of neural circuitry and its influence on behavior and neurological disease. Existing technologies have employed various modalities, such as light, electrical, and magnetic fields, to interface with neural activity. While each method offers unique advantages, many struggle with modulating activity with high spatiotemporal precision without the need for invasive tools...
April 24, 2024: Accounts of Chemical Research
#39
JOURNAL ARTICLE
Magnus Rydberg, Merlin Bruening, Nicholas Manicke
We developed a simple, paper-based device that enables sensitive detection by mass spectrometry (MS) without solid phase extraction or other sample preparation. Using glass fiber filter papers within a 3D printed holder, the device employs electrokinetic manipulations to stack, separate, and desalt charged molecules on paper prior to spray into the MS. Due to counter-balanced electroosmotic flow and electrophoresis, charged analytes stack on the paper and desalting occurs in minutes. One end of the paper strip was cut into a sharp point and positioned near the inlet of a MS...
April 24, 2024: Angewandte Chemie
#40
JOURNAL ARTICLE
Sebastian J Ambach, Georg Krach, Elena Bykova, Kristian Witthaut, Nico Giordano, Maxim Bykov, Wolfgang Schnick
Nitridophosphates and nitridogermanates attract high interest in current research due to their structural versatility. Herein, the elastic properties of GeP2 N4 were investigated by single-crystal X-ray diffraction (XRD) upon compression to 44.4(1) GPa in a diamond anvil cell. Its isothermal bulk modulus was determined to be 82(6) GPa. At 44.4(1) GPa, laser heating resulted in the formation of multiple crystalline phases, one of which was identified as unprecedented germanium nitridophosphate GePN3 . Its structure was elucidated from single-crystal XRD data ( C 2/ c (no...
April 24, 2024: Inorganic Chemistry
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