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https://www.readbyqxmd.com/read/28551942/-prostate-cancer-early-detection-using-psa-current-trends-and-recent-updates
#1
REVIEW
Arnon Lavi, Michael Cohen
Prostate cancer (Pca) is the most common malignancy in men and the second cause of death from cancer. The prostate specific antigen (PSA) assay has been used for Pca screening since the beginning of the 1990's and has brought a 40% reduction in mortality. Since Pca is a diverse disease, early detection can lead to overdetection and overtreatment. Pca treatment has significant adverse effects, namely incontinence and erectile dysfunction. How is it then that a simple and inexpensive test that probably caused the most significant reduction in mortality from cancer ever, is regarded to be "not recommended" by some health organizations? Why did the use of PSA testing fall drastically in the US in the last couple of years, while, at the same time, the tendency for diagnosis of higher risk diseases is noticed through large controlled studies, showing the efficacy of PSA testing in mortality reduction? Will PSA serve as a milestone for early detection and mass population screening in general? This review will deal with aspects of PSA screening and will bring the latest updates and dilemmas concerning this evolving topic...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551939/-is-there-a-way-to-reduce-iron-deficiency-anemia-rates-in-the-second-year-of-life-of-bedouin-children-in-the-negev
#2
Orly Kerub, Hillel Vardi, Boris Knyazer, Natalya Bilenko
INTRODUCTION: Iron deficiency anemia is the most common worldwide nutritional deficiency contributing to childhood morbidity and mortality. According to the official health policy in Israel, providing iron for all babies from the age of 4 months to the age of one year old is recommended. This policy also recommends providing iron supplementation for an additional 6 months for toddlers (who are one year old) with anemia (hemoglobin<11mg/dl). Despite this policy, there is still a high rate of anemia in the Negev's two year old children, especially in the Bedouin population...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551938/-horizontal-canal-benign-paroxysmal-positional-vertigo-hc-bppv-clinical-diagnostic-procedures
#3
REVIEW
Oz Zur, Ophir Ilan, Hadas Ben-Rubi Shimron, Eli Carmeli
Horizontal canal benign paroxysmal positional vertigo (HCBPPV) is one form of benign paroxysmal positional vertigo. HC-BPPV is characterized by intermittent recurrent episodes of vertigo following a change in head position relative to gravity. HC-BPPV prevalence ranges from 5%-33% of all dizziness cases seen in otolaryngology, neurology and family physician clinics. Various factors, such as ear and head injury, can cause HC-BPPV. Cardiovascular disease and iatrogenic reasons are also implicated. Despite the prevalence of the disease, there are various forms of diagnostic procedures, some of which are unfamiliar to the therapist and some are controversial...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551928/-abo-incompatible-kidney-transplantation
#4
Sigal Eisner, Jacob Orlin, Eviatar Nesher, Vadym Mazhybovsky, Michael Gurevich, Rachel Michowiz, Ruth Rahamimov, Eytan Mor
INTRODUCTION: With the introduction of new therapies, the ABO barrier for kidney transplantation has been breached. In the recent decade the reported results with ABO incompatible (ABOi) kidney transplantation are similar to ABO compatible transplantation. We report on our initial experience with ABOi kidney transplantation performed at the Rabin Medical Center. METHODS: During the period 3/2010 to 4/2015, 22 patients with PRA 0% underwent ABOi living-donor kidney transplantation...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551927/-percutaneous-correction-of-forefoot-deformities-in-diabetic-patients-in-order-to-prevent-pressure-sores-technique-and-results-in-20-consecutive-patients
#5
Mustafa Yassin, Avraham Garti, Eyal Heller, Moshe Weissbrot, Dror Robinson
INTRODUCTION: Diabetes mellitus is a 21st century pandemic. Due to life-span prolongation combined with the increased rate of diabetes, a growing population of patients is afflicted with neuropathic foot deformities. Traditional operative repair of these deformities is associated with a high complication rate and relatively common infection incidence. In recent years, in order to prevent these complications, percutaneous deformity correction methods were developed. OBJECTIVES: Description of experience accumulated in treating 20 consecutive patients with diabetic neuropathic foot deformities treated in a percutaneous fashion...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551925/-clinical-characteristics-of-male-patients-with-osteoporosis-referred-to-the-endocrine-clinic-of-a-tertiary-hospital
#6
Gloria Tsvetov, Ilana Shraga-Slutzky, Dania Hirsch, Hiba Masri, Tzippy Shohat, Alexander Gorshtein, Ilan Shimon
INTRODUCTION: Osteoporosis in men is underdiagnosed and undertreated. The prevalence of male osteoporosis increases with age and it becomes a significant public health burden. Currently, there are a few clinical studies on male osteoporosis with limited knowledge of effective therapeutic options. AIMS: Our study aimed to characterize men with osteoporosis in a referral metabolic clinic in Rabin Medical Center at the Beilinson Campus. METHODS: In this study we retrospectively analyzed the medical records of 270 consecutive male patients with osteoporosis diagnosed and treated in our clinic during 2013...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551922/-the-treatment-of-hypertension-by-fixed-drug-combinations-in-patients-hospitalized-at-the-department-of-medicine
#7
Avishay Elis, Amit Akirov
AIMS: To determine the rate of hypertensive patients hospitalized at the department of medicine who are treated or are candidates for fixed dose drug combinations. BACKGROUND: Despite the high prevalence of hypertension and rates of awareness, The number of patients treated and well controlled are low. The main reasons for not achieving blood pressure target levels are compliance and persistence with drug therapy. METHODS: A multicenter, retrospective records review was conducted of hypertensive patients hospitalized at departments of medicine during 2014...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551921/-management-of-anticoagulant-and-antiplatelet-therapy-in-patients-undergoing-planned-endoscopic-procedures
#8
REVIEW
Orly Sneh Arbib, Yaron Niv, Dorit Blickstein
Antithrombotic and antiplatelet therapy is widely used for primary and secondary prevention of venous and arterial diseases. Hemorrhage is a frequent complication in patients taking these drugs, especially during and post invasive procedures. There are several oral anticoagulants and antiplatelet drugs that differ from each other in the mechanism of action and metabolism, the need for drug monitoring, antidote, and the peri-procedural management of the drug. The risk of bleeding in gastrointestinal endoscopic procedures can be high (≥ 1...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551919/-utilization-of-whole-exome-sequencing-in-diagnostics-of-genetic-disease-rabin-medical-center-s-experience
#9
Lior Cohen, Naama Orenstein, Monica Weisz-Hubshman, Lily Bazak, Bella Davidov, Eyal Reinstein, Shay Tzur, Doron Behar, Pola Smirin-Yosef, Mali Salmon-Divon, Amit Gross, Mordechai Shohat, Lina Basel-Vanagaite
INTRODUCTION: Whole exome sequencing is a diagnostic approach for the identification of molecular etiology in patients with suspected monogenic diseases. In this article we report on our experience with whole-exome sequencing (WES) of DNA samples taken from patients referred for genetic evaluation due to suspected undiagnosed genetic conditions. METHODS: Exome enrichment was achieved by Nextera Rapid Capture Expanded Exome Kit. Whole-exome sequencing was performed on Illumina HiSeq 2500...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551918/-rabin-medical-center-a-tertiary-center-of-excellence-in-service-teaching-and-research
#10
Yaron Niv, Eyran Halpern
Rabin Medical Center (RMC) belongs to Clalit Health Services and is a tertiary, academic medical center with all the facilities of modern and advanced medicine. Annually in the RMC, 650,000 patients are treated in the outpatient clinics, and 100,000 patients are hospitalized in the hospital departments. All these patients are treated by 4500 devoted staff members, including 1000 physicians and 2000 nurses. RMC is one of the largest, centrally located medical centers for medical and nursing students' education in Israel, taking place in clinical departments, as well as in basic sciences courses...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551905/-molecular-markers-for-prostate-cancer
#11
REVIEW
Dov Engelstein
Prostate cancer (PCa) is the most frequent malignancy and the second cause of death from malignancy in men in the Western world. Prostatic Specific Antigen (PSA) has been widely used as a possible marker for PCa for the last three decades, but its significant limitations are known, especially its lack of an exact cutoff level for diagnosis of PCa. Imprudent use of PSA has led to over-diagnosis and over-treatment in men with low risk PCa, not significant for survival. Therefore, researchers are looking for better and more accurate markers for diagnosis, treatment decisions and follow-up...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551904/-unknown-title
#12
Moshe Shiller, Vladimir Gens, Ganem Kassem, Wisam Sbeit
BACKGROUND: The relationships between physicians and patients are very complex. One of their principles is to receive informed consent from the patient. This principle facilitates patient autonomy. The physician must explain to the patient: his condition, treatment alternatives, stating the advantages and disadvantages of each option, to enable the patient to choose between them. There are various attitudes towards the health system as a result of different cultures in different societies...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551897/-phacoemulsification-in-eyes-with-neovascular-age-related-macular-degeneration-amd
#13
Daniel Rappoport, Mordechai Goldberg, Amir Bukelman, Haya Katz, Lital Goldberg, Ayala Pollack
INTRODUCTION: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. The debate continues over the safety of cataract surgery in the setting of neovascular (wet) AMD. This retrospective review aims to describe our experience in treating patients with wet AMD, who underwent cataract surgery by phacoemulsification. METHODS: We prepared a retrospective chart review of patients treated in our clinic between the years 2006 - 2013...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551894/-advanced-abdominal-pregnancy
#14
REVIEW
David Rabinerson, Alexandra Berezowsky, Rinnat Gabbay-Benziv
Abdominal pregnancy is a very rare obstetric complication which is seriously hazardous to the mother as well as the fetus. It poses a diagnostic challenge to this day. Both maternal and fetal mortality rates in such cases are high, as well as the malformation rate among the affected fetus. The best diagnostic tools are ultrasound and MRI. The availability of these instruments, and especially the latter, is scarce in developing countries, hence the higher rate of this type of pregnancy in these regions. The higher incidence of abdominal pregnancy in developing countries is also associated with the greater prevalence of low socioeconomic status, pelvic infections and infertility - all are more prevalent in these countries...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551893/-the-rationale-of-minimally-invasive-sinus-technique-mist
#15
REVIEW
Meir Warman, Doron Halperin
Chronic rhinosinusitis is one of the most common diseases in the world. Mucosal contact in narrow draining pathways of the sinuses (called transition spaces) may lead to chronic sinusitis by disruption of mucociliary clearance, stasis and blockage of mucous flow. Minimal invasive sinus technique (MIST) is a targeted procedure designed to address the transition spaces surrounding the natural sinus ostia. Surgical clearing disease in a transition space, allows the dependent sinus to recover function. Compared to other conventional endoscopic procedures, MIST can accomplish good and reproducible results in treating patients for chronic rhinosinusitis over long term follow-up...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551890/-the-challenge-of-providing-high-standard-medical-services-in-a-public-hospital
#16
Shay Nathanson, Carlos Gruzman
Kaplan Medical Center (KMC) provides medical services to about 1 million Israeli citizens. The southern plain region is one of the leading areas in terms of population growth in Israel and as a result, the demand for medical services is constantly on the rise. The workload at KMC is tremendous; over 140,000 referrals to the emergency department with a 6% increase each year. Bed occupancy in the internal wards is above 120% on average per year (the highest in Israel) and ambulatory care referrals are rising at an overwhelming pace...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551884/habitat-monitoring-and-conservation-prioritisation-of-protected-areas-in-western-ghats-kerala-india
#17
K Athira, C Sudhakar Reddy, K R L Saranya, Shijo Joseph, R Jaishanker
Spatially explicit approach is essential to prioritise the ecosystems for biodiversity conservation. In the present study, the conservation status of 20 protected areas of the Western Ghats of Kerala, India, was analysed based on long-term changes in forests (1975-1985-1995-2005-2013), landscape level changes in fragmentation and forest fires (2005-2015). This study has shown that a significant forest loss occurred in protected areas before declaration. Idukki is one of the major protected areas which showed a drastic reduction (18...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28551881/abundance-and-distribution-of-antibiotic-resistance-genes-in-a-full-scale-anaerobic-aerobic-system-alternately-treating-ribostamycin-spiramycin-and-paromomycin-production-wastewater
#18
Mei Tang, Xiaomin Dou, Chunyan Wang, Zhe Tian, Min Yang, Yu Zhang
The occurrence of antibiotic-resistant bacteria and antibiotic resistance genes (ARGs) has been intensively investigated for wastewater treatment systems treating single class of antibiotic in recent years. However, the impacts of alternately occurring antibiotics in antibiotic production wastewater on the behavior of ARGs in biological treatment systems were not well understood yet. Herein, techniques including high-capacity quantitative PCR and quantitative PCR (qPCR) were used to investigate the behavior of ARGs in an anaerobic-aerobic full-scale system...
May 27, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28551877/loss-of-gait-control-assessed-by-cognitive-motor-dual-tasks-pros-and-cons-in-detecting-people-at-risk-of-developing-alzheimer-s-and-parkinson-s-diseases
#19
REVIEW
Maroua Belghali, Nathalie Chastan, Fabien Cignetti, Damien Davenne, Leslie M Decker
Alzheimer's and Parkinson's diseases are age-related progressive neurodegenerative diseases of increasing prevalence worldwide. In the absence of curative therapy, current research is interested in prevention, by identifying subtle signs of early-stage neurodegeneration. Today, the field of behavioral neuroscience has emerged as one of the most promising areas of research on this topic. Recently, it has been shown that the exacerbation of gait disorders under dual-task conditions (i.e., simultaneous performance of cognitive and motor tasks) could be a characteristic feature of Alzheimer's and Parkinson's diseases...
May 27, 2017: GeroScience
https://www.readbyqxmd.com/read/28551866/sequence-and-functional-analysis-of-intestinal-alkaline-phosphatase-from-lateolabrax-maculatus
#20
Minglin Wu, Jiaqi Wang, Zhipeng Wang, Jinliang Zhao, Yuting Hu, Xiaowu Chen
Alkaline phosphatases (Alps) belong to a class of phosphate transferases that dephosphorylate lipopolysaccharide (LPS), adenosine triphosphate, and nucleotides. In this study, a 1874-base pair (bp) intestinal alp cDNA sequence was cloned from Lateolabrax maculatus and designated as Lm-alpi. It contained a 1611 bp open reading frame which encoded a protein with 537 amino acids. Protein sequence alignment showed that Lm-AlpI shared 29.8-79.8% identity with its homologs. Lm-AlpI catalytic sites contained three metal ion sites (two Zn(2+) and one Mg(2+)), referring to D73, H184, D348, H349, H352, H464, D389, and H390 residues, which are essential for enzymatic activity and conservation in different organisms...
May 28, 2017: Fish Physiology and Biochemistry
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