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https://www.readbyqxmd.com/read/29353464/laparoscopic-2port-varicocelectomy-with-scarless-periumblical-mini-incision-initial-experience-in-approach-and-outcomes
#1
Won Ik Seo, Jong Kyou Kwon, Pil Moon Kang, Wansuk Kim, Jang Ho Yoon, Taek Sang Kim, Jae Seung Chung, Cheol Kyu Oh
PURPOSE: As with other areas, there have been many efforts for minimally invasive surgery in varicocelectomy. We present our initial experience with laparoscopic varicocelectomy with a two-port scarless periumbilical mini-incision. MATERIALS AND METHODS: The study enrolled 18 patients who underwent laparoscopic varicocelectomy with a twoportscarless periumbilical mini-incision from February 2012 to April 2013. The laparoscopic varicocelectomy was performed using two 5-mm ports at periumbilical sites in skin creases...
January 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/29353457/fasting-and-fast-food-diet-play-an-opposite-role-in-mice-brain-aging
#2
Paola Castrogiovanni, Giovanni Li Volti, Cristina Sanfilippo, Daniele Tibullo, Fabio Galvano, Michele Vecchio, Roberto Avola, Ignazio Barbagallo, Lucia Malaguarnera, Sergio Castorina, Giuseppe Musumeci, Rosa Imbesi, Michelino Di Rosa
Fasting may be exploited as a possible strategy for prevention and treatment of several diseases such as diabetes, obesity, and aging. On the other hand, high-fat diet (HFD) represents a risk factor for several diseases and increased mortality. The aim of the present study was to evaluate the impact of fasting on mouse brain aging transcriptome and how HFD regulates such pathways. We used the NCBI Gene Expression Omnibus (GEO) database, in order to identify suitable microarray datasets comparing mouse brain transcriptome under fasting or HFD vs aged mouse brain transcriptome...
January 20, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29353446/disentangling-somatosensory-evoked-potentials-of-the-fingers-limitations-and-clinical-potential
#3
Konstantina Kalogianni, Andreas Daffertshofer, Frans C T van der Helm, Alfred C Schouten, Jan C de Munck
In searching for clinical biomarkers of the somatosensory function, we studied reproducibility of somatosensory potentials (SEP) evoked by finger stimulation in healthy subjects. SEPs induced by electrical stimulation and especially after median nerve stimulation is a method widely used in the literature. It is unclear, however, if the EEG recordings after finger stimulation are reproducible within the same subject. We tested in five healthy subjects the consistency and reproducibility of responses through bootstrapping as well as test-retest recordings...
January 20, 2018: Brain Topography
https://www.readbyqxmd.com/read/29353445/hypermethylation-of-nf-%C3%AE%C2%BAb-activating-protein-like-nkapl-promoter-in-hepatocellular-carcinoma-suppresses-its-expression-and-predicts-a-poor-prognosis
#4
Patrick Kwok Shing Ng, Carol Po Ying Lau, Emily Kai Yee Lam, Sheila Sai Kam Li, Vivian Wai Yan Lui, Winnie Yeo, Yuen Keng Ng, Paul Bo San Lai, Stephen Kwok Wing Tsui
BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is a complicated disease with low survival rate partially due to frequent recurrence and no efficient therapy. Promoter hypermethylation of tumor suppressor genes has been demonstrated as one of the molecular mechanisms contributing to tumorigenesis and progression in HCC. This study aims to investigate regulation of NKAPL expression by promoter methylation and its clinical relevance as a biomarker for HCC. METHODS: We measured mRNA expression of NKAPL in 5 HCC cell lines and a cohort of 62 pairs of primary HCC tumor and their adjacent non-cancer liver tissues...
January 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29353436/biomarker-driven-therapy-in-metastatic-gastric-and-esophageal-cancer-real-life-clinical-experience
#5
Ofer Purim, Alexander Beny, Moshe Inbar, Katerina Shulman, Baruch Brenner, Elizabeth Dudnik, Felix Bokstein, Mark Temper, Dror Limon, Diana Matceyevsky, David Sarid, Amiel Segal, Valeriya Semenisty, Ronen Brenner, Tamar Peretz, Efraim Idelevich, Sharon Pelles-Avraham, Amichay Meirovitz, Arie Figer, Kenneth Russell, Andreas Voss, Addie Dvir, Lior Soussan-Gutman, Ayala Hubert
BACKGROUND: Precision treatment of cancer uses biomarker-driven therapy to individualize and optimize patient care. OBJECTIVE: To evaluate real-life clinical experience with biomarker-driven therapy in metastatic gastric and esophageal cancer in Israel. PATIENTS AND METHODS: This multicenter retrospective cohort study included patients with metastatic gastric or esophageal cancer who were treated in the participating institutions and underwent biomarker-driven therapy...
January 20, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29353434/prediction-of-progression-in-skull-base-meningiomas-additional-benefits-of-apparent-diffusion-coefficient-value
#6
Ching-Chung Ko, Sher-Wei Lim, Tai-Yuan Chen, Jeon-Hor Chen, Chien-Feng Li, Yow-Ling Shiue
A subset of benign (WHO grade I) skull base meningiomas show early progression/recurrence (P/R) in the first years after surgical resection. Besides, complete surgical resection may be difficult to achieve safely in skull base meningiomas due to complex neurovascular structures. The one main challenge in the treatment of skull base meningiomas is to determine factors that correlate with P/R. We retrospectively investigated the preoperative CT and MR imaging features for the prediction of P/R in skull base meningiomas, with emphasis on quantitative ADC values...
January 20, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29353426/is-dipyrone-effective-as-a-preemptive-analgesic-in-third-molar-surgery-a-pilot-study
#7
Vinícius Tatsumoto Favarini, Carlos Alysson Aragão Lima, Rogério Almeida da Silva, Fábio Ricardo Loureiro Sato
PURPOSE: Studies on preemptive analgesia in maxillofacial surgery have shown several controversial clinical results, mainly due to the absence of a methodological standard, besides a wide variety of studied drugs. This study intended to answer the following hypothesis: Is the administration of dipyrone preemptively capable of decreasing trans- and postoperative pain in the third molar surgical extraction? METHODS: A pilot prospective double-blind placebo-controlled study was carried out with 25 patients submitted to the third molar surgical extraction at two moments, one side in each intervention...
January 20, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29353421/1-day-or-5-day-fecal-samples-which-one-is-more-beneficial-to-be-used-for-dna-based-gut-microbiota-study
#8
Tingting Su, Rongbei Liu, Yanqin Long, Sheng Quan, Sanchuan Lai, Lan Wang, Jianmin Si, Shujie Chen
Fecal sample collection is an important influential factor for DNA-based gut microbiota study. It is controversial whether the microbiome detected in fecal sample collected at one random day could fully represent the gut microbial community. The aim of the study is to figure out whether the use of fecal sample mixture collected at consecutive 5 days could more accurately represent gut microbial community. 1- and 5-day fecal samples were collected from 8 healthy adults and analyzed by 16S rRNA sequence. Our results indicated that both 1-day fecal samples and 5-day samples exhibited relatively high repeatability...
January 20, 2018: Current Microbiology
https://www.readbyqxmd.com/read/29353417/maternal-metabolic-response-to-dietary-treatment-for-impaired-glucose-tolerance-and-gestational-diabetes-mellitus
#9
Karen L Lindsay, Lorraine Brennan, Maria A Kennelly, Sinéad Curran, Mary Coffey, Thomas P Smith, Michael E Foley, Mensud Hatunic, Fionnuala M McAuliffe
BACKGROUND: Dietary advice is a standard component of treatment for pregnant women with impaired glucose tolerance (IGT) and gestational diabetes (GDM), yet few studies report glycemic profiles in response to dietary therapies and the optimal dietary approach remains uncertain. AIM: To assess changes in maternal glycemic profile and pregnancy outcomes among women with diet-controlled IGT and GDM. METHODS: Pregnant women who had one or more elevated values on a 3-h oral glucose tolerance test were enrolled...
January 20, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29353415/investigation-of-lactic-acid-bacteria-isolated-from-giant-panda-feces-for-potential-probiotics-in-vitro
#10
Qian Liu, Xueqin Ni, Qiang Wang, Zhirong Peng, Lili Niu, Meiling Xie, Yicen Lin, Yi Zhou, Hao Sun, Kangcheng Pan, Bo Jing, Dong Zeng
The present study aimed to isolate an optimal lactic acid bacterial strain from the feces of healthy giant pandas. The strain exhibited good stability at low pH and high bile salt concentrations, activity against pathogens relevant to pandas, and antibiotic susceptibility. In the current study, 25 isolates were obtained from de Man, Rogosa, and Sharpe agar. Two (E21 and G83) and eight (E1, E2, E16, E18, E21, E69, E70, and G83) isolates demonstrated good performance at pH 2.0 and bile 2% (w/v), respectively...
January 20, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29353406/case-report-vertebral-foreign-body-granuloma-mimicking-a-skeletal-metastasis
#11
Josephina A Vossen, Seyed M Bathaii, Bryce Hatfield, Curtis W Hayes
Intraosseous foreign body granuloma formation related to migrated surgical material is a rarely reported condition with variable imaging appearance. In this case report, we describe a foreign body granuloma that occurred in a lumbar vertebral body one level above a prior surgical fusion. The lytic appearance mimicked a skeletal metastasis in a 65-year-old patient with recently diagnosed renal cell carcinoma. To the best of our knowledge, this is the first reported case of a lumbar vertebral foreign body granuloma occurring distant from the site of surgery, indistinguishable from skeletal metastasis on radiologic examination...
January 20, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29353403/genetic-polymorphism-in-hsp90aa1-gene-is-associated-with-the-thermotolerance-in-chinese-holstein-cows
#12
T M Badri, K L Chen, M A Alsiddig, Lian Li, Yafei Cai, G L Wang
The heat shock protein 90 (Hsp90) is a copious and ubiquitous molecular chaperone which plays an essential role in many cellular biological processes. The objective of this study was to identify single nucleotide polymorphisms (SNPs) in the Hsp90AA1 gene and to determine their association with heat stress traits in Chinese Holstein cattle breed. Direct sequencing was used to identify new SNPs. Luciferase reporter assay methods were used to assess g.- 87G > C and g.4172A > G loci in the promoter activity and 3'-UTR, respectively...
January 20, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29353399/mri-findings-in-glutamic-acid-decarboxylase-associated-autoimmune-epilepsy
#13
Jason R Fredriksen, Carrie M Carr, Kelly K Koeller, Jared T Verdoorn, Avi Gadoth, Sean J Pittock, Amy L Kotsenas
PURPOSE: Glutamic acid decarboxylase (GAD65) has been implicated in a number of autoimmune-associated neurologic syndromes, including autoimmune epilepsy. This study categorizes the spectrum of MRI findings in patients with a clinical diagnosis of autoimmune epilepsy and elevated serum GAD65 autoantibodies. METHODS: An institutional database search identified patients with elevated serum GAD65 antibodies and a clinical diagnosis of autoimmune epilepsy who had undergone brain MRI...
January 20, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29353383/religion-and-well-being-the-mediating-role-of-positive-virtues
#14
Swati Sharma, Kamlesh Singh
Researchers have consistently advocated positive associations between religion and well-being. The present research takes a step forward and explores potential mechanisms behind the same. The mediating role of a surprisingly neglected mechanism, positive virtues, specifically gratitude, forgiveness and altruism, is studied through a quantitative study on a sample of 220 adult respondents residing in Delhi NCR. The participants adhered to one of the six major religions present in India. Mediational analysis revealed that gratitude mediated the relationship between religiosity, spirituality and well-being via two pathways of forgiveness and altruism...
January 20, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29353379/coagulase-negative-staphylococci-are-associated-to-the-mild-inflammatory-pattern-of-healthcare-associated-meningitis-a-retrospective-study
#15
S Couffin, D Lobo, F Cook, P H Jost, V Bitot, R Birnbaum, B Nebbad, B Aït-Mamar, W Lahiani, M Martin, G Dhonneur, R Mounier
The epidemiology of healthcare-associated meningitis (HAM) is dominated by commensal bacteria from the skin, as coagulase-negative staphylococci (CoNS). We hypothesized that the pauci-symptomatic and mild inflammatory patterns of HAM are related to the low pathogenic state of CoNS. Our aim was to describe clinical and biological features of CoNS HAM, compared to other HAM. All consecutive patients with HAM admitted in our hospital were retrospectively included from 2007 to 2014. HAM due to CoNS were compared to HAM caused by other bacteria (controls) for clinical and laboratory patterns...
January 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29353357/heath-risk-among-pesticide-sellers-in-bamenda-cameroon-and-peripheral-areas
#16
Jean Sonchieu, Edouard Nantia Akono, Cheche Tanwi Ngwamitang, Benoït Martin Ngassoum
In Bamenda and peripheral zones, studies have been focused on the effects of pesticides on farmers (pesticide users) while nothing has been done to assess the exposure of sellers to pesticides. This study aimed at evaluating the exposure of pesticide sellers in the same area. Thirty-two questionnaires were administered to 32 pesticide sellers systematically selected, and chi-square was used for statistical analysis. From each shop, a respondent was chosen among the workers according to its daily time spent in the workplace...
January 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29353341/field-of-view-normalization-in-multi-site-brain-mri
#17
Yangming Ou, Lilla Zöllei, Xiao Da, Kallirroi Retzepi, Shawn N Murphy, Elizabeth R Gerstner, Bruce R Rosen, P Ellen Grant, Jayashree Kalpathy-Cramer, Randy L Gollub
Multi-site brain MRI analysis is needed in big data neuroimaging studies, but challenging. The challenges lie in almost every analysis step including skull stripping. The diversities in multi-site brain MR images make it difficult to tune parameters specific to subjects or imaging protocols. Alternatively, using constant parameter settings often leads to inaccurate, inconsistent and even failed skull stripping results. One reason is that images scanned at different sites, under different scanners or protocols, and/or by different technicians often have very different fields of view (FOVs)...
January 20, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29353339/chronic-pain-discomfort-quality-of-life-and-impact-on-sex-life-after-open-inguinal-hernia-mesh-repair-an-expertise-based-randomized-clinical-trial-comparing-lightweight-and-heavyweight-mesh
#18
M Rutegård, R Gümüsçü, G Stylianidis, P Nordin, E Nilsson, M M Haapamäki
PURPOSE: There is a paucity of high-quality evidence concerning mesh choice in open inguinal hernia repair. Using an expertise-based randomized clinical trial design, we aimed to evaluate the postoperative impact of two different mesh types on pain and discomfort, quality of life and sex life. METHODS: In two regional hospitals, male patients with primary inguinal hernia were randomized to one of two groups of surgeons that performed the Lichtenstein operation. One group of surgeons used a heavyweight polypropylene mesh (90 g/m2, Bard™ Flatmesh, Davol) while the second group employed a lightweight mesh (28 g/m2, ULTRAPRO™, Ethicon)...
January 20, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29353330/leveraging-variable-sensor-spatial-acuity-with-a-homogeneous-multi-scale-place-recognition-framework
#19
Adam Jacobson, Zetao Chen, Michael Milford
Most robot navigation systems perform place recognition using a single-sensor modality and one, or at most two heterogeneous map scales. In contrast, mammals perform navigation by combining sensing from a wide variety of modalities including vision, auditory, olfactory and tactile senses with a multi-scale, homogeneous neural map of the environment. In this paper, we develop a multi-scale, multi-sensor system for mapping and place recognition that combines spatial localization hypotheses at different spatial scales from multiple different sensors to calculate an overall place recognition estimate...
January 20, 2018: Biological Cybernetics
https://www.readbyqxmd.com/read/29353316/validation-of-a-new-classification-for-periprosthetic-shoulder-fractures
#20
Chlodwig Kirchhoff, Marc Beirer, Ulrich Brunner, Arne Buchholz, Peter Biberthaler, Moritz Crönlein
INTRODUCTION: Successful treatment of periprosthetic shoulder fractures depends on the right strategy, starting with a well-structured classification of the fracture. Unfortunately, clinically relevant factors for treatment planning are missing in the pre-existing classifications. Therefore, the aim of the present study was to describe a new specific classification system for periprosthetic shoulder fractures including a structured treatment algorithm for this important fragility fracture issue...
January 20, 2018: International Orthopaedics
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