Li-Xin Wang, Mutsuyo Takayama-Ito, Hitomi Kinoshita-Yamaguchi, Satsuki Kakiuchi, Tatsuo Suzutani, Kazuo Nakamichi, Chang-Kweng Lim, Ichiro Kurane, Masayuki Saijo
Acyclovir (ACV)-resistant (ACV(r)) mutants were generated from plaque-purified ACV-sensitive herpes simplex virus type 1 (HSV-1) by culturing the virus in Vero cells in the presence of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl) purine (S2242). Three DNA polymerase (DNApol)-associated ACV(r) HSV-1 generated under ACV selection in a previous study (Suzutani, T., Ishioka, K., De Clercq, E., et al., Antimicrob. Agents Chemother., 47, 1707-1713, 2003) were also included. The sensitivity of the mutants to other antivirals and their neurovirulence were determined...
2013: Japanese Journal of Infectious Diseases