J McLaughlin, B Roozendaal, T Dumas, A Gupta, O Ajilore, J Hsieh, D Ho, M Lawrence, J L McGaugh, R Sapolsky
Numerous studies have demonstrated that gene therapy interventions can protect neurons from death after neurological insults. In nearly all such studies, however, "protection" consists of reduced neurotoxicity, with no demonstrated preservation of neuronal function. We used a herpes simplex virus-1 system to overexpress either the Glut-1 glucose transporter (GT) (to buffer energetics), or the apoptosis inhibitor Bcl-2. Both decreased hippocampal neuron loss to similar extents during excitotoxic insults in vitro and in vivo...
November 7, 2000: Proceedings of the National Academy of Sciences of the United States of America