Yunxing Shi, Kai Li, Yichuan Yuan, Chenwei Wang, Zhiwen Yang, Dinglan Zuo, Yi Niu, Jiliang Qiu, Binkui Li, Yunfei Yuan, Wei He
N6-methyladenosine (m6A) is important in regulating mRNA stability, splicing, and translation, and it also contributes to tumor development. However, there is still limited understanding of the comprehensive effects of m6A modification patterns on the tumor immune microenvironment, metabolism, and drug resistance in hepatocellular carcinoma (HCC). In this study, we utilized unsupervised clustering based on the expression of 23 m6A regulators to identify m6A clusters. We identified differential m6A modification patterns and characterized m6A-gene-cluster A, which exhibited poorer survival rates, a higher abundance of Treg cells, and increased expression of TGFβ in the tumor microenvironment (TME)...
April 16, 2024: Cancer Cell International