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Cx43 metoprolol

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https://www.readbyqxmd.com/read/29094045/effect-of-wenxin-granules-on-gap-junction-and-mir-1-in-rats-with-myocardial-infarction
#1
Aiming Wu, Mingjing Zhao, Lixia Lou, Jianying Zhai, Dongmei Zhang, Haiyan Zhu, Yonghong Gao, Hongcai Shang, Limin Chai
Myocardial infarction (MI) patients are at high risk of potential lethal arrhythmia. Gap junction and microRNA-1 (miR-1) are both arrhythmia generating conditions. The present study investigated whether Wenxin Granules (Wenxin-Keli, WXKL) could prevent potential lethal arrhythmia by improving gap junctions and miR-1 following MI. Male Sprague-Dawley rats were divided randomly into control, model, metoprolol, low dose WXKL, and high dose WXKL groups. The MI rat model was created by coronary artery ligation. Treatments were administrated intragastrically to the rats for 4 weeks...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28545280/-impacts-of-early-metoprolol-intervention-on-connexin-43-and-phosphorylated-connexin-43-expression-in-rabbits-with-experimental-myocardial-infarction
#2
M Zhou, Q Lu, J Q Jiang, Z N Chen, Z G Gong, Z G Li, W W Fu, S F Ding
Objective: To investigate the early intervention effects of metoprolol on connexin 43(Cx43) and phosphorylated Cx43 (p-Cx43) expression in rabbits with post myocardial infarction. Methods: A total of 24 adult male New Zealand white rabbits were divided into sham group (n=6), early treatment group(n=6), routine treatment group(n=6), and myocardial infarction group(n=6) with a randomized block design blocked by weight. Myocardial infarction was induced by left anterior descending coronary artery (LAD) ligation...
April 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/24662492/effects-of-nardostachys-chinensis-on-spontaneous-ventricular-arrhythmias-in-rats-with-acute-myocardial-infarction
#3
Jing Zhang, Can-Can Qiang, Wei-Jie Li, Li-Juan Liu, Xiao-Xiong Lin, Yun-Jiu Cheng, Kai Tang, Feng-Juan Yao, Su-Hua Wu
OBJECTIVES: To investigate the effects and mechanisms of Nardostachys chinensis (NC) on spontaneous ventricular arrhythmias in rats with hyper-acute myocardial infarction (AMI). METHODS: Seventy-two rats were randomly divided into the control group (n = 24), metoprolol group (n = 24), and the NC group (n = 24). Premature ventricular contractions (PVCs), ventricular tachycardias (VTs), ventricular fibrillations (VFs), and blood pressure were monitored for 4 hours after coronary artery ligation...
August 2014: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/21542828/effects-of-metoprolol-therapy-on-cardiac-gap-junction-remodelling-and-conduction-in-human-chronic-atrial-fibrillation
#4
S Dhein, S Rothe, A Busch, D M Rojas Gomez, A Boldt, A Reutemann, T Seidel, A Salameh, B Pfannmüller, A Rastan, M Kostelka, F W Mohr
BACKGROUND AND PURPOSE: We investigated the influence of metoprolol on gap junction proteins connexin43 (Cx43) and connexin40 (Cx40) in atrial tissue from patients with/without atrial fibrillation (AF). EXPERIMENTAL APPROACH: Left atrial tissue samples from 160 patients with AF or sinus rhythm (SR) with or without metoprolol (mean daily dose: 65.2 ± 9.1 mg·day⁻¹) were analysed for Cx43 and Cx40 by Western blot and immunohistology. Transverse and longitudinal conduction velocities were determined by 64 multi-electrode mapping...
September 2011: British Journal of Pharmacology
https://www.readbyqxmd.com/read/20966593/restraint-stress-induces-connexin-43-translocation-via-%C3%AE-adrenoceptors-in-rat-heart
#5
Kana Unuma, Kaori Shintani-Ishida, Naoki Yahagi, Kensuke Tsushima, Tatsuo Shimosawa, Takashi Ueyama, Ken-ichi Yoshida
BACKGROUND: Immobilization (IMO) confers emotional stress in animals and humans. It was recently reported that IMO in rats induced translocation of connexin-43 (Cx43) to gap junctions (GJs) and attenuated arrhythmogenesis with GJ inhibition, and Cx43 translocation in the ischemic heart was also shown. Few reports show the contribution of adrenoceptors to Cx43 upregulation in cardiomyocytes, but the involvement of adrenoceptors and ischemia in Cx43 translocation in IMO remains elusive...
November 2010: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/17445419/-the-effects-of-various-beta-blockers-on-myocardial-gap-junction-structure-in-rat-with-myocardial-ischemia-reperfusion-injury
#6
COMPARATIVE STUDY
Shu-ying Fan, Yuan-nan Ke, Yu-jie Zeng, De-chun Su, Yong Wang, Pei Zhang
OBJECTIVE: To compare the effects of carvedilol, metoprolol and propranolol on myocardial gap junction (GJ) structure in rat with myocardial ischemia and reperfusion injury. METHODS: Rats were divided randomly into five groups: sham operation group (SO), myocardial ischemia and reperfusion group (IR), IR + carvedilol group (CV), IR + metoprolol group (MT), and IR + propranolol group (PP). The left anterior descending branch was ligated for 30 minutes and reperfused for 4 hours (IR)...
February 2007: Zhonghua Xin Xue Guan Bing za Zhi
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