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https://www.readbyqxmd.com/read/28662006/-turmeric-not-only-spice
#1
EDITORIAL
Zygmunt Zdrojewicz, Marta Szyca, Ewa Popowicz, Tomasz Michalik, Bartłomiej Śmieszniak
The purpose of this article is to introduce the role of turmeric in medicine and summarize the current state of research on its applications. Turmeric (Curcuma longa) has had a wide range of uses in middle eastern and orietnal traditional medicine. Currently, however, its use has been truncated to a common cooking spice, despite numerous studies pointing to its healing properties and possible use in the treatment of many diseases. The main focus is on curcumin, a polyphenol which serves as the biologically active component of turmeric...
June 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28631890/oxidative-stress-and-psychiatric-morbidity-in-patients-with-facial-acne
#2
Sara M Awad, Hanan Morsy, Ayat A Sayed, Nahed A Mohamed, Ghada M Ezzat, Mostafa M Noaman
BACKGROUND: Acne vulgaris is a common cosmetic problem that is frequently associated with psychosocial disturbances as well as increased oxidative stress. However, oxidative stress and psychological aspects have been studied separately in acne. OBJECTIVE: To evaluate the relationships between oxidative stress, anxiety, depression, and quality of life in acne patients. METHODS: Sixty patients with facial acne and 40 age- and sex-matched healthy individuals were included in the study...
June 20, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28587444/assessment-of-changes-in-the-content-of-anthocyanins-phenolic-acids-and-antioxidant-property-of-saccharomyces-cerevisiae-mediated-fermented-black-rice-bran
#3
Chaiyavat Chaiyasut, Noppawat Pengkumsri, Sasithorn Sirilun, Sartjin Peerajan, Suchanat Khongtan, Bhagavathi Sundaram Sivamaruthi
Studies on phytochemical properties and bioactivities of rice bran revealed the wealth of natural complex antioxidant compounds. The composition and the properties of the rice bran get altered after fermentation by several microbes. This study was designed to optimize the black rice bran fermentation conditions for the total anthocyanin (ACN) content, total antioxidant properties, and relative activity of β-glucosidase (BGS) by Saccharomyces cerevisiae. The Box-Behnken design and response surface methodology was employed to achieve the maximum response in fermentation...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28249743/multifaceted-functions-of-the-forkhead-box-transcription-factors-foxo1-and-foxo3-in-skin
#4
REVIEW
Dimitrios Tsitsipatis, Lars-Oliver Klotz, Holger Steinbrenner
BACKGROUND: The ubiquitously expressed forkhead box, class O (FoxO) transcription factors act as signaling integrators in extensive transcriptional networks, ensuring maintenance of cell and tissue homeostasis over time and in response to environmental challenges. Proteins whose biosynthesis is controlled through FoxOs fulfil key functions in antioxidant defense, metabolism, cell cycle regulation and apoptosis. SCOPE OF REVIEW: All four mammalian FoxO isoforms (FoxO1, FoxO3, FoxO4 and FoxO6) are expressed in skin but functions have been specified only for FoxO1 and FoxO3...
February 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28208738/oral-administration-of-the-japanese-traditional-medicine-keishibukuryogan-ka-yokuinin-decreases-reactive-oxygen-metabolites-in-rat-plasma-identification-of-chemical-constituents-contributing-to-antioxidant-activity
#5
Yosuke Matsubara, Takashi Matsumoto, Kyoji Sekiguchi, Junichi Koseki, Atsushi Kaneko, Takuji Yamaguchi, Yumiko Kurihara, Hiroyuki Kobayashi
Insufficient detoxification and/or overproduction of reactive oxygen species (ROS) induce cellular and tissue damage, and generated reactive oxygen metabolites become exacerbating factors of dermatitis. Keishibukuryogan-ka-yokuinin (KBGY) is a traditional Japanese medicine prescribed to treat dermatitis such as acne vulgaris. Our aim was to verify the antioxidant properties of KBGY, and identify its active constituents by blood pharmacokinetic techniques. Chemical constituents were quantified in extracts of KBGY, crude components, and the plasma of rats treated with a single oral administration of KBGY...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28194718/employing-central-composite-design-for-evaluation-of-biomass-production-by-fusarium-venenatum-in-vivo-antioxidant-and-antihyperlipidemic-properties
#6
Asha Byju Thomas, Trupti Dattatray Shetane, Ranu Goutam Singha, Rabindra K Nanda, Sushilkumar S Poddar, Ajinath Shirsat
The present study deals with the cost effective production of biomass from Fusarium venenatum using different carbon sources (cane sugar, brown sugar, malt and fructose). Optimization of selected carbon sources and seed size using Central Composite Response Surface Design (CCRSD) indicated that sucrose (1.64 g/100 mL) and seed size (10% v/v) were optimal in maximizing biomass yield (0.5602 g/100 mL, p < 0.0001) and protein yield (49.99%, p < 0.01) of Fusarium venenatum. The acetonitrile and methanolic extracts of biomass showed promising antioxidant activity (DPPH assay, 59...
February 13, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28036057/green-tea-and-other-tea-polyphenols-effects-on-sebum-production-and-acne-vulgaris
#7
REVIEW
Suzana Saric, Manisha Notay, Raja K Sivamani
Polyphenols are antioxidant molecules found in many foods including nuts, fruits, vegetables, chocolate, wine, and tea. Polyphenols have antimicrobial, anti-inflammatory, and antineoplastic properties. Recent studies suggest that tea polyphenols may be used for reducing sebum production in the skin and for treatment of acne vulgaris. This review examines the evidence for use of topically and orally ingested tea polyphenols against sebum production and for acne treatment and prevention. The PubMed database was searched for studies on tea polyphenols, sebum secretion, and acne vulgaris...
December 29, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27805044/a-novel-enzyme-with-antioxidant-capacity-produced-by-the-ubiquitous-skin-colonizer-propionibacterium-acnes
#8
Maria Allhorn, Sabine Arve, Holger Brüggemann, Rolf Lood
The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. We show that RoxP binds heme, reduces free radicals, and can protect molecules from oxidation. Strikingly, RoxP is crucial for the survival of P...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27771924/lupeol-and-its-role-in-chronic-diseases
#9
REVIEW
Fan-Shiu Tsai, Li-Wei Lin, Chi-Rei Wu
Lupeol belongs to pentacyclic lupane-type triterpenes and exhibits in edible vegetables, fruits and many plants. Many researches indicated that lupeol possesses many beneficial pharmacological activities including antioxidant, anti-inflammatory, anti-hyperglycemic, anti-dyslipidemic and anti-mutagenic effects. From various disease-targeted animal models, these reports indicated that lupeol has anti-diabetic, anti-asthma, anti-arthritic, cardioprotective, hepatoprotective, nephroprotective, neuroprotective and anticancer efficiency under various routes of administration such as topical, oral, subcutaneous, intraperitoneal and intravenous...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27756097/assessment-of-combined-ascorbyl-palmitate-ap-and-sodium-ascorbyl-phosphate-sap-on-facial-skin-sebum-control-in-female-healthy-volunteers
#10
H Khan, N Akhtar, A Ali
The skin is fortified with a setup of lipophilic and hydrophilic, enzymatic and non-enzymatic antioxidant systems. Ascorbyl palmitate (AP) and sodium ascorbyl phosphate (SAP) are reported as lipophilic and hydrophilic antioxidants, respectively used for skin care. Present study was aimed to assess the combined AP (in oil phase) and SAP (in aqueous phase) via multiple emulsion (ME1) for controlling sebum secretions in healthy human females. FTIR analysis of AP and SAP was performed for identification. Multiple emulsions (ME1 and control) were prepared and analyzed for physical stability...
January 2017: Drug Research
https://www.readbyqxmd.com/read/27720465/inhibition-of-aryl-hydrocarbon-receptor-signaling-and-induction-of-nrf2-mediated-antioxidant-activity-by-cinnamaldehyde-in-human-keratinocytes
#11
Hiroshi Uchi, Mao Yasumatsu, Saori Morino-Koga, Chikage Mitoma, Masutaka Furue
BACKGROUND: Dioxins and other environmental pollutants are toxic and remain in biological tissues for a long time leading to various levels of oxidative stress. Although the toxicity of these agents has been linked to activation of the aryl hydrocarbon receptor (AHR), no effective treatment has been developed. OBJECTIVE: To explore novel phytochemicals that inhibit AHR activation in keratinocytes. METHODS: Keratinocytes were used in this study because the skin is one of the organs most affected by dioxin and other environmental pollutants...
January 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27664647/polyphenolic-composition-and-antioxidant-activity-of-a%C3%A3-ai-euterpe-oleracea-mart-from-colombia
#12
G Astrid Garzón, Carlos-Eduardo Narváez-Cuenca, Jean-Paul Vincken, Harry Gruppen
Berries of Colombian Euterpe oleracea Mart. were analyzed for total phenolic content (TPC), anthocyanin (ACN) content, and antioxidant activity. Additionally, reversed-phase ultra-high performance liquid chromatography with photodiode array detection (RP-UHPLC-PDA) and heated electrospray ionization (HESI) multistage mass spectrometry (MS(n)) were used to determine the composition of phenolic compounds. Anthocyanin content was 0.57±0.39mg cyanidin-3-glucoside/g fresh weight (FW) and TPC was 6.07±2.17mg gallic acid equivalent (GAE)/g FW...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27649502/high-speed-counter-current-chromatography-in-separation-of-betacyanins-from-flowers-of-red-gomphrena-globosa-l-cultivars
#13
Aneta Spórna-Kucab, Ewelina Hołda, Sławomir Wybraniec
Antioxidant and possible chemopreventive properties of betacyanins, natural plant pigments, contribute to a growing interest in their chemistry and separation. Mixtures of betacyanins from fresh red Gomphrena globosa L. cultivar flowers were separated in three highly polar solvent systems by high-speed counter-current chromatography (HSCCC) for a direct comparison of their separation effectiveness. Three samples of crude extract (600mg) were run on semi-preparative scale in solvent system (NH4)2SO4soln - EtOH (2...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27621660/assessment-of-a-new-biological-complex-efficacy-on-dysseborrhea-inflammation-and-propionibacterium-acnes-proliferation
#14
Sandra Trompezinski, Sophie Weber, Benoît Cadars, Florence Larue, Nathalie Ardiet, Marlène Chavagnac-Bonneville, Michèle Sayag, Eric Jourdan
INTRODUCTION: Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous unit triggered by Propionibacterium acnes. A bakuchiol, Ginkgo biloba extract, and mannitol (BGM) complex has been developed to provide patients with acne with a specific dermocosmetic to be used adjunctively with conventional treatments. OBJECTIVE: The aim of these studies was to assess the antibacterial, anti-inflammatory, and antioxidative potential of BGM complex and its individual compounds as well as its impact on sebum composition...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27493450/evaluation-of-the-antioxidative-antibacterial-and-anti-inflammatory-effects-of-the-aloe-fermentation-supernatant-containing-lactobacillus-plantarum-hm218749-1
#15
Meixiu Jiang, Kan Deng, Chunling Jiang, Mingui Fu, Chunlan Guo, Xiaolei Wang, Xin Wang, Fanjing Meng, Shaoguo Yang, Keyu Deng, Tingtao Chen, Hongbo Xin
Little work is done to develop Aloe vera (AV) using probiotics. To explore the potential benefits, the antioxidant effects and the antibacterial effects on foodborne pathogens of Aloe fermentation supernatant were evaluated in vitro. Our results indicated that the Aloe fermentation supernatant fermented by Lactobacillus plantarum HM218749.1 had very strong scavenging capacities of the DPPH (86%), O2 (•-) (85%), (•)OH (76%), and Fe(2+) chelation (82%) and reducing powers (242.5 mg/L), and the inhibition zones for Salmonella typhimurium, Salmonella enteritidis, Shigella flexneri, Escherichia coli, Listeria monocytogenes, S...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27279815/significance-of-diet-in-treated-and-untreated-acne-vulgaris
#16
REVIEW
Alicja Kucharska, Agnieszka Szmurło, Beata Sińska
The relationship between diet and acne is highly controversial. Several studies during the last decade have led dermatologists to reflect on a potential link between diet and acne. This article presents the latest findings on a potential impact that diet can have on pathogenesis of acne vulgaris. The association between diet and acne can no longer be dismissed. Compelling evidence shows that high glycemic load diets may exacerbate acne. Dairy ingestion appears to be weakly associated with acne and the roles of omega-3 fatty acids, dietary fiber, antioxidants, vitamin A, zinc and iodine remain to be elucidated...
April 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27213821/effects-of-turmeric-curcuma-longa-on-skin-health-a-systematic-review-of-the-clinical-evidence
#17
REVIEW
Alexandra R Vaughn, Amy Branum, Raja K Sivamani
Turmeric (Curcuma longa), a commonly used spice throughout the world, has been shown to exhibit antiinflammatory, antimicrobial, antioxidant, and anti-neoplastic properties. Growing evidence shows that an active component of turmeric, curcumin, may be used medically to treat a variety of dermatologic diseases. This systematic review was conducted to examine the evidence for the use of both topical and ingested turmeric/curcumin to modulate skin health and function. The PubMed and Embase databases were systematically searched for clinical studies involving humans that examined the relationship between products containing turmeric, curcumin, and skin health...
August 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27008816/in-vivo-evaluation-of-skin-irritation-potential-melasma-and-sebum-content-following-long-term-application-of-skin-care-cream-in-healthy-adults-using-non-invasive-biometrological-techniques
#18
Atif I Arshad, Shoaib H M Khan, Naveed Akhtar, Asif Mahmood, Rai Muhammad Sarfraz
The present investigation was conducted to evaluate non-invasively, various functional skin parameters i.e., irritation potential, melasma and sebum contents following long term application of topical cream (w/o) loaded with 2% methanolic extract of Ananas comosus L. versus placebo control (base) in healthy adults. Healthy human volunteers (n = 11, aged 20-30 years) were recruited for investigation and written informed consent was taken from each volunteer. In this single blinded study every volunteer applied formulation on one side of face and placebo on the other side of face twice daily for a period of 12 weeks (three months)...
January 2016: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/26962389/addressing-free-radical-oxidation-in-acne-vulgaris
#19
Otto H Mills, Maressa C Criscito, Todd E Schlesinger, Robert Verdicchio, Ernest Szoke
OBJECTIVE: Comparatively little attention has been paid to the role of free radical oxidation in acne vulgaris. Here, using the traditional abnormalities cited for acne, the authors address the role of free radical oxidation throughout the pathogenesis by detailing the chemistry that may contribute to clinical changes. To probe the effects of free radical oxidation and test an antioxidant, they conducted a preliminary study of topically applied vitamin E. METHODS: Seventeen patients with mild-to-moderate acne vulgaris were evaluated over an eight-week period in two private dermatology practices in this open-label study...
January 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/26916232/the-role-of-topical-dermocosmetics-in-acne-vulgaris
#20
REVIEW
E Araviiskaia, B Dréno
Acne is a common chronic inflammatory disease and treatment modalities based on acne severity are well established. The role of dermocosmetics in dermatology, and in particular acne, is becoming more important as more research elucidates the mechanisms of action of products in the pathogenesis of acne. Dermocosmetics have the potential to be used as monotherapy or in combination with medical treatment. Therefore, it has become important for dermatologists to understand dermocosmetics to effectively and appropriately advise patients on their use...
June 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
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