Yaling Wang, Tiezheng Pan, Jie Li, Lina Zou, Xuewen Wei, Qian Zhang, Tingting Wei, Li Xu, Rein V Ulijn, Chunqiu Zhang
Enzymes catalyze almost all material conversion processes within living organisms, yet their natural evolution remains unobserved. Short peptides, derived from proteins and featuring active sites, have emerged as promising building blocks for constructing bioactive supramolecular materials that mimic native proteins through self-assembly. Herein, we employ histidine-containing isomeric tetrapeptides KHFF, HKFF, KFHF, HFKF, FKHF, and FHKF to craft supramolecular self-assemblies, aiming to explore the sequence-activity landscapes of enzyme evolution...
April 21, 2024: ACS Applied Materials & Interfaces