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https://www.readbyqxmd.com/read/29927868/technological-advancements-in-echocardiographic-assessment-of-thoracic-aortic-dilatation-head-to-head-comparison-among-multidetector-computed-tomography-2-dimensional-and-3-dimensional-echocardiography-measurements
#1
Sarah Ghulam Ali, Laura Fusini, Alessia Dalla Cia, Gloria Tamborini, Paola Gripari, Manuela Muratori, Maria E Mancini, Andrea Annoni, Alberto Formenti, Mauro Pepi
PURPOSE: The aim of this study was to evaluate the feasibility and accuracy of 2-dimensional (2D) and 3-dimensional (3D) transthoracic echocardiography (2DTTE, 3DTTE) versus multidetector computed tomography (MDCT) in patients with ascending aortic (AA) dilation. MATERIALS AND METHODS: Fifty consecutive patients with AA dilation were evaluated by 2DTTE, X-plane (XP) 3DTTE, and MDCT. Aorta diameters were measured at aortic annulus, aortic root (SIN), sinotubular junction, AA, aortic arch before the prebrachiocephalic artery (PRE), and before left subclavian artery (INTRA)...
July 2018: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/29911071/radiation-induced-chromosomal-aberrations-and-immunotherapy-micronuclei-cytosolic-dna-and-interferon-production-pathway
#2
REVIEW
Marco Durante, Silvia C Formenti
Radiation-induced chromosomal aberrations represent an early marker of late effects, including cell killing and transformation. The measurement of cytogenetic damage in tissues, generally in blood lymphocytes, from patients treated with radiotherapy has been studied for many years to predict individual sensitivity and late morbidity. Acentric fragments are lost during mitosis and create micronuclei (MN), which are well correlated to cell killing. Immunotherapy is rapidly becoming a most promising new strategy for metastatic tumors, and combination with radiotherapy is explored in several pre-clinical studies and clinical trials...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29907693/exosomes-shuttle-trex1-sensitive-ifn-stimulatory-dsdna-from-irradiated-cancer-cells-to-dendritic-cells
#3
Julie M Diamond, Claire Vanpouille-Box, Sheila Spada, Nils-Petter Rudqvist, Jessica Chapman, Beatrix Ueberheide, Karsten A Pilones, Yasmeen Sarfraz, Silvia C Formenti, Sandra Demaria
Radiotherapy (RT) used at immunogenic doses leads to accumulation of cytosolic double-stranded DNA (dsDNA) in cancer cells, which activates type I IFN (IFN-I) via the cGAS/STING pathway. Cancer cell-derived IFN-I is required to recruit BATF3-dependent dendritic cells (DCs) to poorly immunogenic tumors and trigger antitumor T-cell responses in combination with immune checkpoint blockade. We have previously demonstrated that the exonuclease TREX1 regulates radiation immunogenicity by degrading cytosolic dsDNA...
June 15, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29899030/possible-delayed-diagnosis-and-treatment-of-metastatic-differentiated-thyroid-cancer-by-adopting-the-2015-ata-guidelines
#4
Domenico Albano, Francesco Bertagna, Mattia Bonacina, Rexhep Durmo, Elisabetta Cerudelli, Maria Gazzilli, Maria Beatrice Panarotto, Anna Maria Formenti, Gherando Mazziotti, Andrea Giustina, Raffaele Giubbini
OBJECTIVE: According to the 2015 ATA guidelines, thyroid ablation by iodine-131 (I-131) therapy is absolutely recommended only in patients with high-risk differentiated thyroid cancer (DTC). Often distant metastases are not recognized early and they can stay silent for long time. The aim of our study was to retrospectively analyze the prevalence of metastatic disease before and after I-131 and to evaluate the influence of the new ATA guidelines in the management of DTC. METHODS: We retrospectively analyzed 140 patients showing distant metastases...
June 13, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29897531/how-relevant-are-the-drug-drug-interactions-between-antiretroviral-boosted-based-regimens-and-calcium-channel-blockers-in-real-life
#5
Dario Cattaneo, Tiziana Formenti, Noemi Astuti, Paola Meraviglia, Annalisa Ridolfo, Cristina Gervasoni
No abstract text is available yet for this article.
April 19, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29870292/reply-to-s-c-formenti-et-al
#6
Jason J Luke, Steven J Chmura
No abstract text is available yet for this article.
June 5, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29870291/understanding-responses-to-stereotactic-body-radiotherapy-and-pembrolizumab
#7
Silvia C Formenti, Sandra Demaria
No abstract text is available yet for this article.
June 5, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29859789/hypofractionated-whole-breast-irradiation-in-women-less-than-50-years-old-treated-on-4-prospective-protocols
#8
Fauzia Shaikh, Jessica Chew, Tsivia Hochman, Juhi Purswani, Olivier Maisonet, Elecia Peat, Nelly Huppert, Benjamin T Cooper, Moses Tam, Judith D Goldberg, Carmen A Perez, Silvia C Formenti, Naamit K Gerber
PURPOSE: Hypofractionated whole-breast radiation therapy (RT) has proved to be equivalent to conventionally fractionated RT in multiple randomized trials. There is controversy regarding its use in younger women because of their underrepresentation in trials and the concern for late toxicity. We evaluated disease control and cosmetic outcomes in patients aged <50 years treated with hypofractionated RT in 4 prospective single-institutional trials. METHODS AND MATERIALS: From 2003 to 2015, 1313 patients were enrolled in 4 prospective protocols investigating the use of adjuvant hypofractionated RT after breast-conserving surgery with a daily or weekly concomitant boost...
April 19, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29686020/workshop-report-for-cancer-research-defining-the-shades-of-gy-utilizing-the-biological-consequences-of-radiotherapy-in-the-development-of-new-treatment-approaches-meeting-viewpoint
#9
Mansoor M Ahmed, C Norman Coleman, Marc Mendonca, Soren Bentzen, Bhadrasain Vikram, Stephen M Seltzer, Dudley Goodhead, Ceferino Obcemea, Radhe Mohan, Kevin M Prise, Jacek Capala, Deborah Citrin, Gary Kao, Molykutty Aryankalayil, Iris Eke, Jeffrey C Buchsbaum, Pataje G S Prasanna, Fei-Fei Liu, Quynh-Thu Le, Beverly Teicher, David G Kirsch, DeeDee Smart, Joel Tepper, Silvia Formenti, Daphne Haas-Kogan, David Raben, James Mitchell
No abstract text is available yet for this article.
May 1, 2018: Cancer Research
https://www.readbyqxmd.com/read/29662550/radiotherapy-and-checkpoint-inhibitors-a-winning-new-combination
#10
REVIEW
Eric C Ko, Silvia C Formenti
Immune checkpoint blockade has recently emerged as an important therapeutic approach to the management of malignancies across multiple disease settings. Concomitantly, there has been an increasing appreciation for the role of radiotherapy in eliciting and promoting tumor-directed immune responses. In this review, we discuss the clinical evidence to date on combinations of radiotherapy with immune checkpoint inhibitors, both from the standpoint of safety and efficacy. We highlight important but yet-unanswered questions for this combination approach, as well as their implications for future prospective studies...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29661221/practice-patterns-and-outcomes-for-patients-with-node-negative-hormone-receptor-positive-breast-cancer-and-intermediate-21-gene-recurrence-scores
#11
Jonathan Chen, Xian Wu, Paul J Christos, Silvia Formenti, Himanshu Nagar
BACKGROUND: The recommendation for chemotherapy in early-stage breast cancer patients has been refined by the 21-gene Recurrence Score. However, uncertainty remains whether patients in the Intermediate Risk category benefit from chemotherapy. METHODS: We analyzed female patients from the National Cancer Database from 2006 to 2012 who had pT1c-T2N0M0 breast cancer, were ER/PR-positive and HER2-negative, received endocrine therapy, and had a 21-gene Recurrence Score from 11 to 25...
April 16, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29602723/impact-of-a-new-adaptive-statistical-iterative-reconstruction-asir-v-algorithm-on-image-quality-in-coronary-computed-tomography-angiography
#12
Gianluca Pontone, Giuseppe Muscogiuri, Daniele Andreini, Andrea I Guaricci, Marco Guglielmo, Andrea Baggiano, Fabio Fazzari, Saima Mushtaq, Edoardo Conte, Andrea Annoni, Alberto Formenti, Elisabetta Mancini, Massimo Verdecchia, Alessandro Campari, Chiara Martini, Marco Gatti, Laura Fusini, Lorenzo Bonfanti, Elisa Consiglio, Mark G Rabbat, Antonio L Bartorelli, Mauro Pepi
RATIONALE AND OBJECTIVES: A new postprocessing algorithm named adaptive statistical iterative reconstruction (ASIR)-V has been recently introduced. The aim of this article was to analyze the impact of ASIR-V algorithm on signal, noise, and image quality of coronary computed tomography angiography. MATERIALS AND METHODS: Fifty consecutive patients underwent clinically indicated coronary computed tomography angiography (Revolution CT; GE Healthcare, Milwaukee, WI)...
March 27, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29598848/dual-transforming-growth-factor-%C3%AE-and-programmed-death-1-blockade-a-strategy-for-immune-excluded-tumors
#13
Claire Vanpouille-Box, Silvia C Formenti
Tumors that elude infiltration by CD8+ T lymphocytes are particularly resistant to multiple forms of treatment, including immune checkpoint blockade. Stromal transforming growth factor (TGF)-β appears to play a key role in this process, potentially constituting a target for novel combinatorial regimens tackling immune-excluded neoplasms.
June 2018: Trends in Immunology
https://www.readbyqxmd.com/read/29589579/field-investigation-with-real-time-virus-genetic-characterisation-support-of-a-cluster-of-ebola-virus-disease-cases-in-dubr%C3%A3-ka-guinea-april-to-june-2015
#14
Alessandro Pini, Delayo Zomahoun, Sophie Duraffour, Tarik Derrough, Myrna Charles, Joshua Quick, Nick Loman, Lauren Cowley, Mamadou Leno, Nobila Ouedraogo, Oumou Thiam, Alfonso Hernández-Romieu, Annie Iko, Halimatou Keita, Djiba Konate, Aboubacar Aboubak Soumah, Etran Bouchouar, Samuel Ileka-Priouzeau, Sakoba Keita, Boubacar Diallo, Fode Cisse, Josep Jansa, Miles Carroll, Stephan Günther, Ettore Severi, Pierre Formenty
On 11 May 2015, the Dubréka prefecture, Guinea, reported nine laboratory-confirmed cases of Ebola virus disease (EVD). None could be epidemiologically linked to cases previously reported in the prefecture. We describe the epidemiological and molecular investigations of this event. We used the Dubréka EVD registers and the Ebola treatment centre's (ETC) records to characterise chains of transmission. Real-time field Ebola virus sequencing was employed to support epidemiological results. An epidemiological cluster of 32 cases was found, of which 27 were laboratory confirmed, 24 were isolated and 20 died...
March 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29589416/conscious-sedation-in-critically-ill-patients-is-associated-with-stressors-perception-lower-than-assessed-by-caregivers
#15
Giovanni Mistraletti, Michele Umbrello, Vera Mariani, Elisabetta Carloni, Sara Miori, Martina Taverna, Giovanni Sabbatini, Paolo Formenti, Stefano Terzoni, Anne L Destrebecq, Davide Chiumello, Egidio A Moja, Gaetano Iapichino
BACKGROUND: In ICU, the stay is frequently a stressful experience. Caregivers may help to understand patients' perceptions; however, their reliability is uncertain. Despite the recent recommendations of lighter sedation targets, little is known about the impact of "conscious sedation" on ICU patients memories. Purpose of this prospective, observational study is to analyze the stress perception in consciously-sedated ICU-patients, comparing it to caregivers and staff members...
March 27, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29548066/immunotherapy-plus-stereotactic-radiosurgery-building-on-the-promise-of-precision-medicine-for-cns-malignancies-part-2-existing-experience-and-considerations-for-future-trials
#16
REVIEW
Isabella Zhang, Silvia C Formenti, Jonathan P S Knisely
The brain has long been considered an immunologically privileged site, and the role of immunotherapy in treating intracranial disease has only recently been revived-with preclinical evidence showing that the systemic immune system responds to immunotherapy for intracranial disease, and with clinical evidence demonstrating improved locoregional control and survival compared with historical outcomes when immune-directed therapies are combined with radiation. Pharmaceutical industry-supported multi-institutional drug efficacy studies routinely exclude patients with brain metastases, so current evidence for treatment of brain metastases using stereotactic radiosurgery combined with immunotherapy comes from single-institution studies...
March 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29547359/molecular-and-serological-evidence-of-the-presence-of-midichloria-mitochondrii-in-roe-deer-capreolus-capreolus-in-france
#17
Valentina Serra, Alessandra Cafiso, Nicoletta Formenti, Hélène Verheyden, Olivier Plantard, Chiara Bazzocchi, Davide Sassera
Midichloria mitochondrii is a tick-borne intracellular bacterium of the order Rickettsiales, found with high prevalence in the sheep tick ( Ixodes ricinus). Midichloria mitochondrii is capable of vertical transmission in the tick, but recently evidence of potential horizontal transmission to the tick hosts through the blood meal has been reported. We investigated the presence of the bacterium in the blood of roe deer ( Capreolus capreolus) collected from an area known to be highly infested with I. ricinus ticks...
March 16, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29527223/pten-at-the-interface-of-immune-tolerance-and-tumor-suppression
#18
Andrew Brandmaier, Sheng-Qi Hou, Sandra Demaria, Silvia C Formenti, Wen H Shen
BACKGROUND: PTEN is well known to function as a tumor suppressor that antagonizes oncogenic signaling and maintains genomic stability. The PTEN gene is frequently deleted or mutated in human cancers and the wide cancer spectrum associated with PTEN deficiency has been recapitulated in a variety of mouse models of Pten deletion or mutation. Pten mutations are highly penetrant in causing various types of spontaneous tumors that often exhibit resistance to anticancer therapies including immunotherapy...
June 2017: Frontiers in Biology
https://www.readbyqxmd.com/read/29507831/bilateral-asymmetry-of-skin-temperature-is-not-related-to-bilateral-asymmetry-of-crank-torque-during-an-incremental-cycling-exercise-to-exhaustion
#19
Athos Trecroci, Damiano Formenti, Nicola Ludwig, Marco Gargano, Andrea Bosio, Ermanno Rampinini, Giampietro Alberti
Although moderate relationships (| r | ∼ 0.5) were reported between skin temperature and performance-related variables (e.g., kinetic), it remains unclear whether skin temperature asymmetry reflects muscle force imbalance in cycling. Therefore, the aim of this study was to assess whether a relationship exists between kinetic and thermal asymmetry during a fatiguing exercise. Ten elite cyclists were enrolled and tested on a maximal incremental cycling test. Peak crank torques of both legs were obtained at the initial and final workload...
2018: PeerJ
https://www.readbyqxmd.com/read/29506722/diagnostic-performance-of-coronary-ct-angiography-carried-out-with-a-novel-whole-heart-coverage-high-definition-ct-scanner-in-patients-with-high-heart-rate
#20
Daniele Andreini, Saima Mushtaq, Gianluca Pontone, Edoardo Conte, Marco Guglielmo, Andrea Annoni, Andrea Baggiano, Alberto Formenti, Valentina Ditali, Maria Elisabetta Mancini, Simone Zanchi, Eleonora Melotti, Daniela Trabattoni, Piero Montorsi, Paolo Mario Ravagnani, Cesare Fiorentini, Antonio L Bartorelli, Mauro Pepi
BACKGROUND: Aim of the study was to evaluate image quality, radiation exposure and diagnostic accuracy of coronary CT angiography (CCTA) performed with a novel cardiac CT scanner in patients with very high heart rate (HR). METHODS: We prospectively enrolled 202 patients (111 men, mean age 66±8years) with suspected coronary artery disease who underwent CCTA with a whole-organ volumetric CT scanner. The HR during the scan was ≥80bpm in 100 patients (Group 1), while it was ≤65bpm in the remaining 102 patients (Group 2)...
April 15, 2018: International Journal of Cardiology
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