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https://www.readbyqxmd.com/read/29037377/thermographic-imaging-in-sports-and-exercise-medicine-a-delphi-study-and-consensus-statement-on-the-measurement-of-human-skin-temperature
#1
REVIEW
Danilo Gomes Moreira, Joseph T Costello, Ciro J Brito, Jakub G Adamczyk, Kurt Ammer, Aaron J E Bach, Carlos M A Costa, Clare Eglin, Alex A Fernandes, Ismael Fernández-Cuevas, José J A Ferreira, Damiano Formenti, Damien Fournet, George Havenith, Kevin Howell, Anna Jung, Glen P Kenny, Eleazar S Kolosovas-Machuca, Matthew J Maley, Arcangelo Merla, David D Pascoe, Jose I Priego Quesada, Robert G Schwartz, Adérito R D Seixas, James Selfe, Boris G Vainer, Manuel Sillero-Quintana
The importance of using infrared thermography (IRT) to assess skin temperature (tsk) is increasing in clinical settings. Recently, its use has been increasing in sports and exercise medicine; however, no consensus guideline exists to address the methods for collecting data in such situations. The aim of this study was to develop a checklist for the collection of tsk using IRT in sports and exercise medicine. We carried out a Delphi study to set a checklist based on consensus agreement from leading experts in the field...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29016305/real-time-polymerase-chain-reaction-assay-on-bronchoalveolar-lavage-an-alternative-method-for-diagnosing-chronic-pulmonary-schistosomiasis
#2
Federico Gobbi, Fabio Formenti, Francesca Perandin, Dora Buonfrate, Andrea Angheben, Simona Paiano, Zeno Bisoffi
Schistosomiasis causes mainly hepatic and genitourinary damage. Although lung nodules have been commonly described in acute phase, they are presumably underdiagnosed in chronic schistosomiasis. We previously reported a series of patients with chronic pulmonary schistosomiasis confirmed by the histological examination of the lung biopsies. In the present work, we retrospectively tested an in-house real-time polymerase chain reaction for Schistosoma (currently validated for diagnosis on stool and on urine) in the bronchoalveolar lavage (BAL) of a couple of those patients, and both resulted positive...
October 9, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28932642/trex1-dictates-the-immune-fate-of-irradiated-cancer-cells
#3
Claire Vanpouille-Box, Silvia C Formenti, Sandra Demaria
The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA. TREX1 upregulation by radiation dose per fraction beyond a threshold of 10-12 Gy results in poor synergy with immune checkpoint blockers.
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28892501/implementation-of-a-study-to-examine-the-persistence-of-ebola-virus-in-the-body-fluids-of-ebola-virus-disease-survivors-in-sierra-leone-methodology-and-lessons-learned
#4
Gibrilla Fadlu Deen, Suzanna L R McDonald, Jaclyn E Marrinan, Foday R Sesay, Elizabeth Ervin, Anna E Thorson, Wenbo Xu, Ute Ströher, Patricia Ongpin, Neetu Abad, Archchun Ariyarajah, Tasneem Malik, Hongtu Liu, Christine Ross, Kara N Durski, Philippe Gaillard, Oliver Morgan, Pierre Formenty, Barbara Knust, Nathalie Broutet, Foday Sahr
BACKGROUND: The 2013-2016 West African Ebola virus disease epidemic was unprecedented in terms of the number of cases and survivors. Prior to this epidemic there was limited data available on the persistence of Ebola virus in survivors' body fluids and the potential risk of transmission, including sexual transmission. METHODOLOGY/PRINCIPAL FINDINGS: Given the urgent need to determine the persistence of Ebola virus in survivors' body fluids, an observational cohort study was designed and implemented during the epidemic response operation in Sierra Leone...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28885530/emotional-intelligence-and-burnout-in-academic-radiation-oncology-chairs
#5
Emma B Holliday, James A Bonner, Silvia C Formenti, Stephen M Hahn, Shalom Kalnicki, Fei-Fei Liu, Benjamin Movsas, Clifton D Fuller, Charles R Thomas
The importance of emotional intelligence (EI) in physicians has attracted attention as researchers begin to focus on the relationship of EI to retention, promotion, and productivity among academic physicians. However, to date, no formal evaluation of EI has been conducted among current department chairs. The objectives of this study were to assess the EI of current chairs of academic radiation oncology departments and to correlate EI with a self-reported assessment of burnout.The authors invited 95 chairs of academic radiation oncology departments to participate in a survey, approved by an institutional review board, consisting of the Trait Emotional Intelligence Questionnaire Short Form (TEIQue-SF) and the abbreviated Maslach Burnout Inventory (a-MBI)...
September 2017: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28880058/acromegaly-and-bone
#6
Filippo Maffezzoni, Anna M Formenti
INTRODUCTION: Growth hormone (GH) and insulin-like growth factor-I (IGF-1) have pleiotropic effects on the skeleton throughout the lifespan by influencing bone formation and resorption. Despite these positive effects on skeletal metabolism, in presence of GH and IGF-1 excess, bone turnover increases excessively leading to deterioration of bone microarchitecture and high risk of fragility fractures, thereby impairing quality of life. EVIDENCE ACQUISITION: Coexistent hypogonadism, diabetes mellitus, hypovitaminosis D, hyperparathyroidism and over-replacement with glucocorticoids impair bone framework, however, the effects of acromegaly on bone mineral density (BMD) are still controversial and despite normalization of bone turnover after treatment, the risk for fractures remains increased...
September 7, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28878215/respiratory-oscillations-in-alveolar-oxygen-tension-measured-in-arterial-blood
#7
Federico Formenti, Nikhil Bommakanti, Rongsheng Chen, John N Cronin, Hanne McPeak, Delphine Holopherne-Doran, Goran Hedenstierna, Clive E W Hahn, Anders Larsson, Andrew D Farmery
Arterial oxygen partial pressure can increase during inspiration and decrease during expiration in the presence of a variable shunt fraction, such as with cyclical atelectasis, but it is generally presumed to remain constant within a respiratory cycle in the healthy lung. We measured arterial oxygen partial pressure continuously with a fast intra-vascular sensor in the carotid artery of anaesthetized, mechanically ventilated pigs, without lung injury. Here we demonstrate that arterial oxygen partial pressure shows respiratory oscillations in the uninjured pig lung, in the absence of cyclical atelectasis (as determined with dynamic computed tomography), with oscillation amplitudes that exceeded 50 mmHg, depending on the conditions of mechanical ventilation...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28836162/prevalence-of-morphometric-vertebral-fractures-in-difficult-patients-with-acromegaly-with-different-biochemical-outcomes-after-multimodal-treatment
#8
S Chiloiro, M Mormando, A Bianchi, A Giampietro, D Milardi, C Bima, G Grande, A M Formenti, G Mazziotti, A Pontecorvi, A Giustina, L De Marinis
INTRODUCTION: Skeletal fragility with high risk of vertebral fractures is an emerging complication of acromegaly in close relationship with duration of active disease. The aim of this cross-sectional study was to evaluate the prevalence and determinants of vertebral fractures in males and females with a history of long-standing active acromegaly undergoing treatment with Pegvisomant. SUBJECTS AND METHODS: Thirty-eight patients (25 females, 13 males) with acromegaly under Pegvisomant therapy were evaluated for vertebral fractures and bone mineral density at lumbar spine and femoral neck...
August 23, 2017: Endocrine
https://www.readbyqxmd.com/read/28770842/persistent-anthrax-as-a-major-driver-of-wildlife-mortality-in-a-tropical-rainforest
#9
Constanze Hoffmann, Fee Zimmermann, Roman Biek, Hjalmar Kuehl, Kathrin Nowak, Roger Mundry, Anthony Agbor, Samuel Angedakin, Mimi Arandjelovic, Anja Blankenburg, Gregory Brazolla, Katherine Corogenes, Emmanuel Couacy-Hymann, Tobias Deschner, Paula Dieguez, Karsten Dierks, Ariane Düx, Susann Dupke, Henk Eshuis, Pierre Formenty, Yisa Ginath Yuh, Annemarie Goedmakers, Jan F Gogarten, Anne-Céline Granjon, Scott McGraw, Roland Grunow, John Hart, Sorrel Jones, Jessica Junker, John Kiang, Kevin Langergraber, Juan Lapuente, Kevin Lee, Siv Aina Leendertz, Floraine Léguillon, Vera Leinert, Therese Löhrich, Sergio Marrocoli, Kerstin Mätz-Rensing, Amelia Meier, Kevin Merkel, Sonja Metzger, Mizuki Murai, Svenja Niedorf, Hélène De Nys, Andreas Sachse, Joost van Schijndel, Ulla Thiesen, Els Ton, Doris Wu, Lothar H Wieler, Christophe Boesch, Silke R Klee, Roman M Wittig, Sébastien Calvignac-Spencer, Fabian H Leendertz
Anthrax is a globally important animal disease and zoonosis. Despite this, our current knowledge of anthrax ecology is largely limited to arid ecosystems, where outbreaks are most commonly reported. Here we show that the dynamics of an anthrax-causing agent, Bacillus cereus biovar anthracis, in a tropical rainforest have severe consequences for local wildlife communities. Using data and samples collected over three decades, we show that rainforest anthrax is a persistent and widespread cause of death for a broad range of mammalian hosts...
August 2, 2017: Nature
https://www.readbyqxmd.com/read/28751442/towards-precision-radiotherapy-for-use-with-immune-checkpoint-blockers
#10
Claire Vanpouille-Box, Silvia C Formenti, Sandra Demaria
The first evidence that radiation therapy (RT) enhances the efficacy of immune checkpoint blockers (ICBs) was obtained a dozen years ago in a mouse model of metastatic carcinoma refractory to anti-CTLA-4 treatment. At the time, ICBs had just entered clinical testing, an endeavor that culminated in 2011 with the approval of the first anti-CTLA-4 antibody for use in metastatic melanoma patients (ipilimumab). Thereafter, some patients progressing on ipilimumab showed systemic responses only upon receiving radiation to one lesion, confirming clinically the pro-immunogenic effects of radiation...
July 27, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28740908/preplanning-prediction-of-the-left-anterior-descending-artery-maximum-dose-based-on-patient-dosimetric-and-treatment-planning-parameters
#11
Benjamin T Cooper, Xiaochun Li, Samuel M Shin, Aram S Modrek, Howard C Hsu, J K DeWyngaert, Gabor Jozsef, Stella C Lymberis, Judith D Goldberg, Silvia C Formenti
PURPOSE: Maximum dose to the left anterior descending artery (LADmax) is an important physical constraint to reduce the risk of cardiovascular toxicity. We generated a simple algorithm to guide the positioning of the tangent fields to reliably maintain LADmax <10 Gy. METHODS AND MATERIALS: Dosimetric plans from 146 consecutive women treated prone to the left breast enrolled in prospective protocols of accelerated whole breast radiation therapy, with a concomitant daily boost to the tumor bed (40...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28650569/biomass-derived-catalysts-for-selective-hydrogenation-of-nitroarenes
#12
Basudev Sahoo, Dario Formenti, Christoph Topf, Stephan Bachmann, Michelangelo Scalone, Kathrin Junge, Matthias Beller
Development of catalytically active materials from biowaste represents an important aspect of sustainable chemical research. Three heterogeneous materials were synthesized from inexpensive biomass-based chitosan and abundant Co(OAc)2 using complexation followed by pyrolysis at various temperatures. These materials were applied in the catalytic hydrogenation of nitroarenes using molecular hydrogen. A variety of diversely functionalized nitroarenes including some pharmaceutically active compounds were converted into aromatic amines in high yields, with high selectivity, and with excellent functional group tolerance...
August 10, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28598415/dna-exonuclease-trex1-regulates-radiotherapy-induced-tumour-immunogenicity
#13
Claire Vanpouille-Box, Amandine Alard, Molykutty J Aryankalayil, Yasmeen Sarfraz, Julie M Diamond, Robert J Schneider, Giorgio Inghirami, C Norman Coleman, Silvia C Formenti, Sandra Demaria
Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We show that the DNA exonuclease Trex1 is induced by radiation doses above 12-18 Gy in different cancer cells, and attenuates their immunogenicity by degrading DNA that accumulates in the cytosol upon radiation. Cytosolic DNA stimulates secretion of interferon-β by cancer cells following activation of the DNA sensor cGAS and its downstream effector STING...
June 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28583942/management-of-endocrine-disease-risk-of-overtreatment-in-patients-with-adrenal-insufficiency-current-and-emerging-aspects
#14
REVIEW
G Mazziotti, A M Formenti, S Frara, E Roca, P Mortini, A Berruti, A Giustina
The effects of long-term replacement therapy of adrenal insufficiency (AI) are still a matter of controversy. In fact, the established glucocorticoid replacement regimens do not completely reproduce the endogenous hormonal production and the monitoring of AI treatment may be a challenge for the lack of reliable clinical and biochemical markers. Consequently, several AI patients are frequently exposed to relative glucocorticoid excess potentially leading to develop chronic complications, such as diabetes mellitus, dyslipidemia, hypertension and fragility fractures with consequent impaired QoL and increased mortality risk...
November 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28582412/accuracy-of-parasitological-and-immunological-tests-for-the-screening-of-human-schistosomiasis-in-immigrants-and-refugees-from-african-countries-an-approach-with-latent-class-analysis
#15
Anna Beltrame, Massimo Guerriero, Andrea Angheben, Federico Gobbi, Ana Requena-Mendez, Lorenzo Zammarchi, Fabio Formenti, Francesca Perandin, Dora Buonfrate, Zeno Bisoffi
BACKGROUND: Schistosomiasis is a neglected infection affecting millions of people, mostly living in sub-Saharan Africa. Morbidity and mortality due to chronic infection are relevant, although schistosomiasis is often clinically silent. Different diagnostic tests have been implemented in order to improve screening and diagnosis, that traditionally rely on parasitological tests with low sensitivity. Aim of this study was to evaluate the accuracy of different tests for the screening of schistosomiasis in African migrants, in a non endemic setting...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28562016/brown-carbon-production-in-ammonium-or-amine-containing-aerosol-particles-by-reactive-uptake-of-methylglyoxal-and-photolytic-cloud-cycling
#16
David O De Haan, Lelia N Hawkins, Hannah G Welsh, Raunak Pednekar, Jason R Casar, Elyse A Pennington, Alexia de Loera, Natalie G Jimenez, Michael A Symons, Melanie Zauscher, Aki Pajunoja, Lorenzo Caponi, Mathieu Cazaunau, Paola Formenti, Aline Gratien, Edouard Pangui, Jean-François Doussin
The effects of methylglyoxal uptake on the physical and optical properties of aerosol containing amines or ammonium sulfate were determined before and after cloud processing in a temperature- and RH-controlled chamber. The formation of brown carbon was observed upon methylglyoxal addition, detected as an increase in water-soluble organic carbon mass absorption coefficients below 370 nm and as a drop in single-scattering albedo at 450 nm. The imaginary refractive index component k450 reached a maximum value of 0...
June 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28551359/previous-radiotherapy-and-the-clinical-activity-and-toxicity-of-pembrolizumab-in-the-treatment-of-non-small-cell-lung-cancer-a-secondary-analysis-of-the-keynote-001-phase-1-trial
#17
Narek Shaverdian, Aaron E Lisberg, Krikor Bornazyan, Darlene Veruttipong, Jonathan W Goldman, Silvia C Formenti, Edward B Garon, Percy Lee
BACKGROUND: Preclinical studies have found radiotherapy enhances antitumour immune responses. We aimed to assess disease control and pulmonary toxicity in patients who previously received radiotherapy for non-small-cell lung cancer (NSCLC) before receiving pembrolizumab. METHODS: We assessed patients with advanced NSCLC treated on the phase 1 KEYNOTE-001 trial at a single institution (University of California, Los Angeles, CA, USA). Patients were aged 18 years or older, had an Eastern Cooperative Oncology Group performance status of 1 or less, had adequate organ function, and no history of pneumonitis...
July 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28520958/development-use-and-impact-of-a-global-laboratory-database-during-the-2014-ebola-outbreak-in-west-africa
#18
Kara N Durski, Shalini Singaravelu, Junxiong Teo, Dhamari Naidoo, Luke Bawo, Amara Jambai, Sakoba Keita, Ali Ahmed Yahaya, Beatrice Muraguri, Brice Ahounou, Victoria Katawera, Fredson Kuti-George, Yacouba Nebie, T Henry Kohar, Patrick Jowlehpah Hardy, Mamoudou Harouna Djingarey, David Kargbo, Nuha Mahmoud, Yewondwossen Assefa, Orla Condell, Magassouba N'Faly, Leon Van Gurp, Margaret Lamanu, Julia Ryan, Boubacar Diallo, Foday Daffae, Dikena Jackson, Fayyaz Ahmed Malik, Philomena Raftery, Pierre Formenty
Background: The international impact, rapid widespread transmission, and reporting delays during the 2014 Ebola outbreak in West Africa highlighted the need for a global, centralized database to inform outbreak response. The World Health Organization and Emerging and Dangerous Pathogens Laboratory Network addressed this need by supporting the development of a global laboratory database. Methods: Specimens were collected in the affected countries from patients and dead bodies meeting the case definitions for Ebola virus disease...
June 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28493000/serological-and-molecular-tests-for-the-diagnosis-of-strongyloides-stercoralis-infection-in-dogs
#19
Dora Buonfrate, Paola Paradies, Fabrizio Iarussi, Fabio Formenti, Francesca Perandin, Domenico Otranto, Zeno Bisoffi
Strongyloides stercoralis can cause severe infection both in humans and dogs. Coproparasitological examination has low sensitivity for the diagnosis of this parasite; hence, different diagnostic techniques have been implemented. However, serology and molecular methods have been assessed almost exclusively in humans. In this study, two serologic assays and a real-time PCR (RT-PCR), routinely used for the diagnosis of strongyloidiasis in humans, have been tested for the diagnosis in dogs. Five dogs living in the same kennel in Bari, southern Italy, were diagnosed with S...
July 2017: Parasitology Research
https://www.readbyqxmd.com/read/28471861/somatic-testing-on-gynecological-cancers-improve-the-identification-of-lynch-syndrome
#20
Ileana Carnevali, Laura Libera, Annamaria Chiaravalli, Nora Sahnane, Daniela Furlan, Alessandra Viel, Giulia Cini, Laura Cimetti, Thomas Rossi, Giorgio Formenti, Fabio Ghezzi, Cristina Riva, Fausto Sessa, Maria Grazia Tibiletti
OBJECTIVE: Recent data from the literature indicate gynecological cancers (GCs) as sentinel cancers for a diagnosis of Lynch syndrome (LS). Clinical approaches to identifying LS have low sensitivity, whereas somatic tests on GCs may be a more sensitive and cost-effective strategy. METHODS: A series of 78 GCs belonging to 74 patients sent to the Genetic Counselling Service were investigated using microsatellite instability, immunohistochemical expression of mismatch repair (MMR) genes, and MLH1 promoter methylation...
September 2017: International Journal of Gynecological Cancer
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