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https://www.readbyqxmd.com/read/28650569/sustainable-biomass-derived-catalysts-for-selective-hydrogenation-of-nitroarenes
#1
Basudev Sahoo, Dario Formenti, Christoph Topf, Stephan Bachmann, Michelangelo Scalone, Kathrin Junge, Matthias Beller
Development of catalytically active materials from biowaste represents an important aspect of sustainable chemical research. Three heterogeneous materials were synthesized from inexpensive biomass based chitosan and abundant Co(OAc)₂via complexation followed by pyrolysis at various temperatures. These materials were applied for the catalytic hydrogenation of nitroarenes using molecular hydrogen. A variety of diversely functionalized nitroarenes including few pharmaceutically active compounds were selectively converted to aromatic amines in high yield and selectivity with excellent functional group tolerance...
June 26, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28598415/dna-exonuclease-trex1-regulates-radiotherapy-induced-tumour-immunogenicity
#2
Claire Vanpouille-Box, Amandine Alard, Molykutty J Aryankalayil, Yasmeen Sarfraz, Julie M Diamond, Robert J Schneider, Giorgio Inghirami, C Norman Coleman, Silvia C Formenti, Sandra Demaria
Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We show that the DNA exonuclease Trex1 is induced by radiation doses above 12-18 Gy in different cancer cells, and attenuates their immunogenicity by degrading DNA that accumulates in the cytosol upon radiation. Cytosolic DNA stimulates secretion of interferon-β by cancer cells following activation of the DNA sensor cGAS and its downstream effector STING...
June 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28583942/management-of-endocrine-disease-risk-of-overtreatment-of-patients-with-adrenal-insufficiency-current-and-emerging-aspects
#3
Gherardo Mazziotti, Anna Maria Formenti, Stefano Frara, Elisa Roca, Pietro Mortini, Alfredo Berruti, Andrea Giustina
The effects of long-term replacement therapy of adrenal insufficiency (AI) are still a matter of controversy. In fact, the established glucocorticoid replacement regimens do not completely mirror the endogenous hormonal production and the monitoring of AI treatment may be a challenge for the lack of reliable biochemical markers. Consequently, several AI patients may be exposed to relative glucocorticoid excess that, even if mild, may potentially lead to development of chronic complications, such as diabetes mellitus, dyslipidemia, hypertension and fragility fractures with consequent impaired QoL and increased mortality risk...
June 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28582412/accuracy-of-parasitological-and-immunological-tests-for-the-screening-of-human-schistosomiasis-in-immigrants-and-refugees-from-african-countries-an-approach-with-latent-class-analysis
#4
Anna Beltrame, Massimo Guerriero, Andrea Angheben, Federico Gobbi, Ana Requena-Mendez, Lorenzo Zammarchi, Fabio Formenti, Francesca Perandin, Dora Buonfrate, Zeno Bisoffi
BACKGROUND: Schistosomiasis is a neglected infection affecting millions of people, mostly living in sub-Saharan Africa. Morbidity and mortality due to chronic infection are relevant, although schistosomiasis is often clinically silent. Different diagnostic tests have been implemented in order to improve screening and diagnosis, that traditionally rely on parasitological tests with low sensitivity. Aim of this study was to evaluate the accuracy of different tests for the screening of schistosomiasis in African migrants, in a non endemic setting...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28562016/brown-carbon-production-in-ammonium-or-amine-containing-aerosol-particles-by-reactive-uptake-of-methylglyoxal-and-photolytic-cloud-cycling
#5
David O De Haan, Lelia N Hawkins, Hannah G Welsh, Raunak Pednekar, Jason R Casar, Elyse A Pennington, Alexia de Loera, Natalie G Jimenez, Michael A Symons, Melanie Zauscher, Aki Pajunoja, Lorenzo Caponi, Mathieu Cazaunau, Paola Formenti, Aline Gratien, Edouard Pangui, Jean-François Doussin
The effects of methylglyoxal uptake on the physical and optical properties of aerosol containing amines or ammonium sulfate were determined before and after cloud processing in a temperature- and RH-controlled chamber. The formation of brown carbon was observed upon methylglyoxal addition, detected as an increase in water-soluble organic carbon mass absorption coefficients below 370 nm and as a drop in single-scattering albedo at 450 nm. The imaginary refractive index component k450 reached a maximum value of 0...
June 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28551359/previous-radiotherapy-and-the-clinical-activity-and-toxicity-of-pembrolizumab-in-the-treatment-of-non-small-cell-lung-cancer-a-secondary-analysis-of-the-keynote-001-phase-1-trial
#6
Narek Shaverdian, Aaron E Lisberg, Krikor Bornazyan, Darlene Veruttipong, Jonathan W Goldman, Silvia C Formenti, Edward B Garon, Percy Lee
BACKGROUND: Preclinical studies have found radiotherapy enhances antitumour immune responses. We aimed to assess disease control and pulmonary toxicity in patients who previously received radiotherapy for non-small-cell lung cancer (NSCLC) before receiving pembrolizumab. METHODS: We assessed patients with advanced NSCLC treated on the phase 1 KEYNOTE-001 trial at a single institution (University of California, Los Angeles, CA, USA). Patients were aged 18 years or older, had an Eastern Cooperative Oncology Group performance status of 1 or less, had adequate organ function, and no history of pneumonitis...
July 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28520958/the-development-use-and-impact-of-a-global-laboratory-database-during-the-2014-ebola-outbreak-in-west-africa
#7
Kara N Durski, Shalini Singaravelu, Junxiong Teo, Dhamari Naidoo, Luke Bawo, Amara Jambai, Sakoba Keita, Ali Ahmed Yahaya, Beatrice Muraguri, Brice Ahounou, Victoria Katawera, Fredson Kuti-George, Yacouba Nebie, T Henry Kohar, Patrick Jowlehpah Hardy, Mamoudou Harouna Djingarey, David Kargbo, Nuha Mahmoud, Yewondwossen Assefa, Orla Condell, Magassouba N'Faly, Leon Van Gurp, Margaret Lamanu, Julia Ryan, Boubacar Diallo, Foday Daffae, Dikena Jackson, Fayyaz Ahmed Malik, Philomena Raftery, Pierre Formenty
Background: The international impact, rapid widespread transmission, and reporting delays during the 2014 Ebola virus disease (EVD) outbreak in West Africa highlighted the need for a global, centralized database to inform outbreak response. The World Health Organization and Emerging and Dangerous Pathogens Laboratory Network addressed this need by supporting the development of a global laboratory database. Methods: Specimens were collected in the affected countries from patients and dead bodies meeting the case definitions for EVD...
May 18, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28493000/serological-and-molecular-tests-for-the-diagnosis-of-strongyloides-stercoralis-infection-in-dogs
#8
Dora Buonfrate, Paola Paradies, Fabrizio Iarussi, Fabio Formenti, Francesca Perandin, Domenico Otranto, Zeno Bisoffi
Strongyloides stercoralis can cause severe infection both in humans and dogs. Coproparasitological examination has low sensitivity for the diagnosis of this parasite; hence, different diagnostic techniques have been implemented. However, serology and molecular methods have been assessed almost exclusively in humans. In this study, two serologic assays and a real-time PCR (RT-PCR), routinely used for the diagnosis of strongyloidiasis in humans, have been tested for the diagnosis in dogs. Five dogs living in the same kennel in Bari, southern Italy, were diagnosed with S...
July 2017: Parasitology Research
https://www.readbyqxmd.com/read/28471861/somatic-testing-on-gynecological-cancers-improve-the-identification-of-lynch-syndrome
#9
Ileana Carnevali, Laura Libera, Annamaria Chiaravalli, Nora Sahnane, Daniela Furlan, Alessandra Viel, Giulia Cini, Laura Cimetti, Thomas Rossi, Giorgio Formenti, Fabio Ghezzi, Cristina Riva, Fausto Sessa, Maria Grazia Tibiletti
OBJECTIVE: Recent data from the literature indicate gynecological cancers (GCs) as sentinel cancers for a diagnosis of Lynch syndrome (LS). Clinical approaches to identifying LS have low sensitivity, whereas somatic tests on GCs may be a more sensitive and cost-effective strategy. METHODS: A series of 78 GCs belonging to 74 patients sent to the Genetic Counselling Service were investigated using microsatellite instability, immunohistochemical expression of mismatch repair (MMR) genes, and MLH1 promoter methylation...
May 2, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28459810/external-quality-assessment-study-for-ebolavirus-pcr-diagnostic-promotes-international-preparedness-during-the-2014-2016-ebola-outbreak-in-west-africa
#10
MULTICENTER STUDY
Heinz Ellerbrok, Sonja Jacobsen, Pranav Patel, Toni Rieger, Markus Eickmann, Stephan Becker, Stephan Günther, Dhamari Naidoo, Livia Schrick, Kathrin Keeren, Angelina Targosz, Anette Teichmann, Pierre Formenty, Matthias Niedrig
During the recent Ebola outbreak in West Africa several international mobile laboratories were deployed to the mainly affected countries Guinea, Sierra Leone and Liberia to provide ebolavirus diagnostic capacity. Additionally, imported cases and small outbreaks in other countries required global preparedness for Ebola diagnostics. Detection of viral RNA by reverse transcription polymerase chain reaction has proven effective for diagnosis of ebolavirus disease and several assays are available. However, reliability of these assays is largely unknown and requires serious evaluation...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28445682/atrial-fibrillation-diagnostic-accuracy-of-coronary-ct-angiography-performed-with-a-whole-heart-230-%C3%A2%C2%B5m-spatial-resolution-ct-scanner
#11
Daniele Andreini, Gianluca Pontone, Saima Mushtaq, Edoardo Conte, Marco Perchinunno, Marco Guglielmo, Valentina Volpato, Andrea Annoni, Andrea Baggiano, Alberto Formenti, Maria Elisabetta Mancini, Virginia Beltrama, Valentina Ditali, Alessandro Campari, Cesare Fiorentini, Antonio L Bartorelli, Mauro Pepi
Purpose To assess image quality, interpretability, diagnostic accuracy, and radiation exposure of a computed tomography (CT) scanner with 16-cm coverage and 230-µm spatial resolution at coronary artery evaluation in patients with atrial fibrillation (AF) by using invasive coronary angiography (ICA) as the reference method and to compare the results with those obtained in patients with sinus rhythm (SR). Materials and Methods Written informed consent and institutional ethics committee approval were obtained...
April 26, 2017: Radiology
https://www.readbyqxmd.com/read/28419317/high-dose-and-high-frequency-lanreotide-autogel-in-acromegaly-a-randomized-multicenter-study
#12
Andrea Giustina, Gherardo Mazziotti, Salvatore Cannavò, Roberto Castello, Giorgio Arnaldi, Giovanna Bugari, Renato Cozzi, Diego Ferone, Anna Maria Formenti, Enza Gatti, Silvia Grottoli, Pietro Maffei, Filippo Maffezzoni, Marcella Montini, Massimo Terzolo, Ezio Ghigo
Context: The increase in drug frequency or dose is recommended for acromegaly patients with partial response to long-acting somatostatin receptor ligands (SRLs). However, the efficacy and safety data with lanreotide autogel (LAN-ATG) at high-dose (HD) or high-frequency (HF) are still scanty and anecdotal. Objective: To evaluate the biochemical efficacy and safety of HF- and HD LAN-ATG in patients with active acromegaly. Design: 24-week prospective, multicentre, randomized, open-label trial...
April 17, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28417329/quantitative-cancer-risk-assessment-and-local-mortality-burden-for-ambient-air-pollution-in-an-eastern-mediterranean-city
#13
Hassan R Dhaini, Thérèse Salameh, Antoine Waked, Stéphane Sauvage, Agnès Borbon, Paola Formenti, Jean-François Doussin, Nadine Locoge, Charbel Afif
Health risks posed by ambient air pollutants to the urban Lebanese population have not been well characterized. The aim of this study is to assess cancer risk and mortality burden of non-methane hydrocarbons (NMHCs) and particulates (PM) based on two field-sampling campaigns conducted during summer and winter seasons in Beirut. Seventy NMHCs were analyzed by TD-GC-FID. PM2.5 elemental carbon (EC) components were examined using a Lab OC-EC aerosol Analyzer, and polycyclic aromatic hydrocarbons were analyzed by GC-MS...
April 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28405497/results-of-a-phase-i-ii-study-of-adjuvant-concurrent-carboplatin-and-accelerated-radiotherapy-for-triple-negative-breast-cancer
#14
Silvia C Formenti, Encouse B Golden, Judith D Goldberg, Xiaochun Li, Jessica Taff, Maria B Fenton-Kerimian, Sharanya Chandrasekhar, Sandra Demaria, Yelena Novik
Purpose: To determine feasibility and explore the clinical efficacy of concurrent radiotherapy and carboplatin as adjuvant treatment of triple negative breast cancer (TNBC). Patients and Methods: Women with Stage I-II TNBC were treated after surgery in a phase I-II prospective trial [NCT01289353]. Weekly carboplatin (AUC = 2.0) was delivered for 6 weeks. Concurrent radiotherapy was delivered in the prone position during weeks 2-4, for a total dose of 40.5 Gy in 15 fractions to the breast, and 46.5 Gy in 17 fractions to the tumor bed...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28405027/virus-genomes-reveal-factors-that-spread-and-sustained-the-ebola-epidemic
#15
Gytis Dudas, Luiz Max Carvalho, Trevor Bedford, Andrew J Tatem, Guy Baele, Nuno R Faria, Daniel J Park, Jason T Ladner, Armando Arias, Danny Asogun, Filip Bielejec, Sarah L Caddy, Matthew Cotten, Jonathan D'Ambrozio, Simon Dellicour, Antonino Di Caro, Joseph W Diclaro, Sophie Duraffour, Michael J Elmore, Lawrence S Fakoli, Ousmane Faye, Merle L Gilbert, Sahr M Gevao, Stephen Gire, Adrianne Gladden-Young, Andreas Gnirke, Augustine Goba, Donald S Grant, Bart L Haagmans, Julian A Hiscox, Umaru Jah, Jeffrey R Kugelman, Di Liu, Jia Lu, Christine M Malboeuf, Suzanne Mate, David A Matthews, Christian B Matranga, Luke W Meredith, James Qu, Joshua Quick, Suzan D Pas, My V T Phan, Georgios Pollakis, Chantal B Reusken, Mariano Sanchez-Lockhart, Stephen F Schaffner, John S Schieffelin, Rachel S Sealfon, Etienne Simon-Loriere, Saskia L Smits, Kilian Stoecker, Lucy Thorne, Ekaete Alice Tobin, Mohamed A Vandi, Simon J Watson, Kendra West, Shannon Whitmer, Michael R Wiley, Sarah M Winnicki, Shirlee Wohl, Roman Wölfel, Nathan L Yozwiak, Kristian G Andersen, Sylvia O Blyden, Fatorma Bolay, Miles W Carroll, Bernice Dahn, Boubacar Diallo, Pierre Formenty, Christophe Fraser, George F Gao, Robert F Garry, Ian Goodfellow, Stephan Günther, Christian T Happi, Edward C Holmes, Brima Kargbo, Sakoba Keïta, Paul Kellam, Marion P G Koopmans, Jens H Kuhn, Nicholas J Loman, N'Faly Magassouba, Dhamari Naidoo, Stuart T Nichol, Tolbert Nyenswah, Gustavo Palacios, Oliver G Pybus, Pardis C Sabeti, Amadou Sall, Ute Ströher, Isatta Wurie, Marc A Suchard, Philippe Lemey, Andrew Rambaut
The 2013-2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic 'gravity' model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic...
April 20, 2017: Nature
https://www.readbyqxmd.com/read/28396471/contact-tracing-performance-during-the-ebola-virus-disease-outbreak-in-kenema-district-sierra-leone
#16
Mikiko Senga, Alpha Koi, Lina Moses, Nadia Wauquier, Philippe Barboza, Maria Dolores Fernandez-Garcia, Etsub Engedashet, Fredson Kuti-George, Aychiluhim Damtew Mitiku, Mohamed Vandi, David Kargbo, Pierre Formenty, Stephane Hugonnet, Eric Bertherat, Christopher Lane
Contact tracing in an Ebola virus disease (EVD) outbreak is the process of identifying individuals who may have been exposed to infected persons with the virus, followed by monitoring for 21 days (the maximum incubation period) from the date of the most recent exposure. The goal is to achieve early detection and isolation of any new cases in order to prevent further transmission. We performed a retrospective data analysis of 261 probable and confirmed EVD cases in the national EVD database and 2525 contacts in the Contact Line Lists in Kenema district, Sierra Leone between 27 April and 4 September 2014 to assess the performance of contact tracing during the initial stage of the outbreak...
May 26, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28389807/taxonomy-of-the-order-mononegavirales-update-2017
#17
Gaya K Amarasinghe, Yīmíng Bào, Christopher F Basler, Sina Bavari, Martin Beer, Nicolás Bejerman, Kim R Blasdell, Alisa Bochnowski, Thomas Briese, Alexander Bukreyev, Charles H Calisher, Kartik Chandran, Peter L Collins, Ralf G Dietzgen, Olga Dolnik, Ralf Dürrwald, John M Dye, Andrew J Easton, Hideki Ebihara, Qi Fang, Pierre Formenty, Ron A M Fouchier, Elodie Ghedin, Robert M Harding, Roger Hewson, Colleen M Higgins, Jian Hong, Masayuki Horie, Anthony P James, Dàohóng Jiāng, Gary P Kobinger, Hideki Kondo, Gael Kurath, Robert A Lamb, Benhur Lee, Eric M Leroy, Ming Li, Andrea Maisner, Elke Mühlberger, Sergey V Netesov, Norbert Nowotny, Jean L Patterson, Susan L Payne, Janusz T Paweska, Michael N Pearson, Rick E Randall, Peter A Revill, Bertus K Rima, Paul Rota, Dennis Rubbenstroth, Martin Schwemmle, Sophie J Smither, Qisheng Song, David M Stone, Ayato Takada, Calogero Terregino, Robert B Tesh, Keizo Tomonaga, Noël Tordo, Jonathan S Towner, Nikos Vasilakis, Viktor E Volchkov, Victoria Wahl-Jensen, Peter J Walker, Beibei Wang, David Wang, Fei Wang, Lin-Fa Wang, John H Werren, Anna E Whitfield, Zhichao Yan, Gongyin Ye, Jens H Kuhn
In 2017, the order Mononegavirales was expanded by the inclusion of a total of 69 novel species. Five new rhabdovirus genera and one new nyamivirus genus were established to harbor 41 of these species, whereas the remaining new species were assigned to already established genera. Furthermore, non-Latinized binomial species names replaced all paramyxovirus and pneumovirus species names, thereby accomplishing application of binomial species names throughout the entire order. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV)...
August 2017: Archives of Virology
https://www.readbyqxmd.com/read/28368352/melatonin-pharmacological-blood-levels-increase-total-antioxidant-capacity-in-critically-ill-patients
#18
RANDOMIZED CONTROLLED TRIAL
Giovanni Mistraletti, Rita Paroni, Michele Umbrello, Lara D'Amato, Giovanni Sabbatini, Martina Taverna, Paolo Formenti, Elena Finati, Gaia Favero, Francesca Bonomini, Rita Rezzani, Russel J Reiter, Gaetano Iapichino
In this study, the aim was to test the biochemical effects of melatonin supplementation in Intensive Care Unit (ICU) patients, since their blood levels are decreased. Sixty-four patients were enrolled in the study. From the evening of the 3rd ICU day, patients were randomized to receive oral melatonin (3 mg, group M) or placebo (group P) twice daily, at 20:00 and 24:00, until discharged. Blood was taken (at 00:00 and 14:00), on the 3rd ICU day to assess basal nocturnal melatonin values, and then during the treatment period on the 4th and 8th ICU days...
April 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28364356/diabetes-in-cushing-disease
#19
REVIEW
G Mazziotti, A M Formenti, S Frara, F Maffezzoni, M Doga, A Giustina
PURPOSE OF REVIEW: This review focuses on the pathophysiological and clinical aspects of diabetes mellitus occurring in patients with Cushing disease (CD). RECENT FINDINGS: Insulin resistance and impairment in insulin secretion are both involved in the pathogenesis of glucocorticoid-induced diabetes. Correction of glucocorticoid excess does not always resolve abnormalities of glucose homeostasis, and correction of hyperglycaemia is specifically required. In fact, insulin resistance may persist even after correction of glucocorticoid excess and diabetes needs to be treated for long term...
May 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28349853/molecular-identification-of-cryptic-cysticercosis-taenia-ovis-krabbei-in-wild-intermediate-and-domestic-definitive-hosts
#20
N Formenti, M Chiari, T Trogu, A Gaffuri, C Garbarino, M B Boniotti, C Corradini, P Lanfranchi, N Ferrari
The complex life cycle of taeniids represents an ideal model of a multi-host system. The complexity of these parasites can therefore cover the epidemiological issues of the interface between wild and domestic animals, especially once spatial overlap between wild and domestic definitive and intermediate hosts occurs. Here we use the occurrence of Taenia ovis krabbei in two model areas as an example of this epidemiological complexity. In two contiguous areas in the Italian northern Apennines, two hunted roe deer (Capreolus capreolus) showed numerous cysticerci in the muscles of their whole body and an adult tapeworm was recorded in a semi-stray dog (Canis lupus familiaris)...
March 28, 2017: Journal of Helminthology
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