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https://www.readbyqxmd.com/read/27916820/biological-control-beneath-the-feet-a-review-of-crop-protection-against-insect-root-herbivores
#1
REVIEW
Alan Kergunteuil, Moe Bakhtiari, Ludovico Formenti, Zhenggao Xiao, Emmanuel Defossez, Sergio Rasmann
Sustainable agriculture is certainly one of the most important challenges at present, considering both human population demography and evidence showing that crop productivity based on chemical control is plateauing. While the environmental and health threats of conventional agriculture are increasing, ecological research is offering promising solutions for crop protection against herbivore pests. While most research has focused on aboveground systems, several major crop pests are uniquely feeding on roots. We here aim at documenting the current and potential use of several biological control agents, including micro-organisms (viruses, bacteria, fungi, and nematodes) and invertebrates included among the macrofauna of soils (arthropods and annelids) that are used against root herbivores...
November 29, 2016: Insects
https://www.readbyqxmd.com/read/27894070/the-strategy-study-stress-cardiac-magnetic-resonance-versus-computed-tomography-coronary-angiography-for-the-management-of-symptomatic-revascularized-patients-resources-and-outcomes-impact
#2
Gianluca Pontone, Daniele Andreini, Andrea I Guaricci, Cristina Rota, Marco Guglielmo, Saima Mushtaq, Andrea Baggiano, Virginia Beltrama, Laura Fusini, Anna Solbiati, Chiara Segurini, Edoardo Conte, Paola Gripari, Andrea Annoni, Alberto Formenti, Maria Petulla', Federico Lombardi, Giuseppe Muscogiuri, Antonio L Bartorelli, Mauro Pepi
BACKGROUND: Computed tomography coronary angiography (cTCA) and stress cardiac magnetic resonance (stress-CMR) are suitable tools for diagnosing obstructive coronary artery disease in symptomatic patients with previous history of revascularization. However, performance appraisal of noninvasive tests must take in account the consequent diagnostic testing, invasive procedures, clinical outcomes, radiation exposure, and cumulative costs rather than their diagnostic accuracy only. We aimed to compare an anatomic (cTCA) versus a functional (stress-CMR) strategy in symptomatic patients with previous myocardial revascularization procedures...
October 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27888758/left-atrium-and-pulmonary-vein-imaging-using-sub-millisiviert-cardiac-computed-tomography-impact-on-radiofrequency-catheter-ablation-cumulative-radiation-exposure-and-outcome-in-atrial-fibrillation-patients
#3
Gianluca Pontone, Daniele Andreini, Maria Petulla, Andrea Annoni, Andrea I Guaricci, Ester Innocenti, Eleonora Russo, Marco Guglielmo, Saima Mushtaq, Andrea Baggiano, Virginia Beltrama, Laura Fusini, Chiara Segurini, Edoardo Conte, Alberto Formenti, Gaetano Fassini, Stefania Riva, Claudio Tondo, Piergiuseppe Agostoni, Antonio L Bartorelli, Mauro Pepi
BACKGROUND: The outcome of radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) has improved thanks to left atrium (LA) anatomy reconstruction by cardiac computed tomography (CCT). A new model-based iterative reconstruction algorithm (MBIR) provides image noise reduction achieving effective radiation dose (ED) close to chest X-ray exposure. Aim of this study was comparing RFCA procedural characteristics, AF recurrence and radiation exposure between patients in whom RFCA was guided by CCT image integration with MBIR versus a CCT standard protocol...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27877170/comparison-of-s-stercoralis-serology-performed-on-dried-blood-spots-and-on-conventional-serum-samples
#4
Fabio Formenti, Dora Buonfrate, Rosanna Prandi, Monica Marquez, Cintia Caicedo, Eleonora Rizzi, Angel G Guevara, Yosselin Vicuña, Francisco R Huerlo, Francesca Perandin, Zeno Bisoffi, Mariella Anselmi
Background: Dried blood spots (DBS) are used for epidemiological surveys on infectious diseases in settings where limited resources are available. In fact, DBS can help to overcome logistic difficulties for the collection, transport and storage of biological specimens. Objective: To evaluate the accuracy of Strongyloides stercoralis serology performed on DBS. Methods: A survey was proposed to children attending a school in the village of Borbon, Ecuador, and to their parents/guardians. Each participant gave consent to the collection of both serum and DBS specimens...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27869596/unusual-ebola-virus-chain-of-transmission-conakry-guinea-2014-2015
#5
Mory Keita, Sophie Duraffour, Nicholas J Loman, Andrew Rambaut, Boubacar Diallo, Nfaly Magassouba, Miles W Carroll, Joshua Quick, Amadou A Sall, Judith R Glynn, Pierre Formenty, Lorenzo Subissi, Ousmane Faye
In October 2015, a new case of Ebola virus disease in Guinea was detected. Case investigation, serology, and whole-genome sequencing indicated possible transmission of the virus from an Ebola virus disease survivor to another person and then to the case-patient reported here. This transmission chain over 11 months suggests slow Ebola virus evolution.
December 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27869095/does-heavy-ion-therapy-work-through-the-immune-system
#6
Marco Durante, David J Brenner, Silvia C Formenti
No abstract text is available yet for this article.
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27855489/acute-effects-of-kinesio-taping-on-a-6-s-maximal-cycling-sprint-performance
#7
Athos Trecroci, Damiano Formenti, Alessio Rossi, Fabio Esposito, Giampietro Alberti
Based on the hypothesis that tactile stimulation affects muscle activation levels, we theorized that taping vastus medialis and vastus lateralis muscles would improve a 6 s sprint cycling performance. Thus, the aim of this study was to determine whether the use of kinesio taping (KT) was helpful in increasing maximal-intensity cycling exercise. Sixteen active healthy subjects were enrolled in a randomized placebo, repeated measures design. All subjects were tested on a cycle ergometer under three conditions: without taping, taping along anterior thigh muscles and sham taping across the same muscle groups...
November 18, 2016: Research in Sports Medicine
https://www.readbyqxmd.com/read/27845767/activating-autophagy-to-potentiate-immunogenic-chemotherapy-and-radiation-therapy
#8
REVIEW
Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Sandra Demaria, Silvia Chiara Formenti, Guido Kroemer
Autophagy is fundamental to the maintenance of intracellular homeostasis in virtually all human cells. Accordingly, defective autophagy predisposes healthy cells to undergoing malignant transformation. By contrast, malignant cells are able to harness autophagy to thrive, despite adverse microenvironmental conditions, and to resist therapeutic challenges. Thus, inhibition of autophagy has been proposed as a strategy to kill cancer cells or sensitize them to therapy; however, autophagy is also critical for optimal immune function, and mediates cell-extrinsic homeostatic effects owing to its central role in danger signalling by neoplastic cells responding to immunogenic chemotherapy and/or radiation therapy...
November 15, 2016: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/27830281/a-family-information-brochure-and-dedicated-website-to-improve-the-icu-experience-for-patients-relatives-an-italian-multicenter-before-and-after-study
#9
Giovanni Mistraletti, Michele Umbrello, Elena Silvia Mantovani, Benedetta Moroni, Paolo Formenti, Paolo Spanu, Stefania Anania, Elisa Andrighi, Alessandra Di Carlo, Federica Martinetti, Irene Vecchi, Alessandra Palo, Cristina Pinna, Riccarda Russo, Silvia Francesconi, Federico Valdambrini, Enrica Ferretti, Giulio Radeschi, Edda Bosco, Paolo Malacarne, Gaetano Iapichino
PURPOSE: Good communication between ICU staff and patients' relatives may reduce the occurrence of post-traumatic stress disorder, anxiety or depression, and dissatisfaction with clinicians. An information brochure and website to meet relatives' needs were designed to explain in technical yet simple terms what happens during and after an ICU stay, to legitimize emotions such as fear, apprehension, and suffering, and to improve cooperation with relatives without increasing staff workload...
November 9, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27798405/possibility-and-challenges-of-conversion-of-current-virus-species-names-to-linnaean-binomials
#10
Thomas S Postler, Anna N Clawson, Gaya K Amarasinghe, Christopher F Basler, Sina Bavari, Mária Benkő, Kim R Blasdell, Thomas Briese, Michael J Buchmeier, Alexander Bukreyev, Charles H Calisher, Kartik Chandran, Rémi Charrel, Christopher S Clegg, Peter L Collins, Juan Carlos de la Torre, Joseph L DeRisi, Ralf G Dietzgen, Olga Dolnik, Ralf Dürrwald, John M Dye, Andrew J Easton, Sébastian Emonet, Pierre Formenty, Ron A M Fouchier, Elodie Ghedin, Jean-Paul Gonzalez, Balázs Harrach, Roger Hewson, Masayuki Horie, Dàohóng Jiāng, Gary Kobinger, Hideki Kondo, Andrew M Kropinski, Mart Krupovic, Gael Kurath, Robert A Lamb, Eric M Leroy, Igor S Lukashevich, Andrea Maisner, Arcady R Mushegian, Sergey V Netesov, Norbert Nowotny, Jean L Patterson, Susan L Payne, Janusz T Paweska, Clarence J Peters, Sheli R Radoshitzky, Bertus K Rima, Victor Romanowski, Dennis Rubbenstroth, Sead Sabanadzovic, Hélène Sanfaçon, Maria S Salvato, Martin Schwemmle, Sophie J Smither, Mark D Stenglein, David M Stone, Ayato Takada, Robert B Tesh, Keizo Tomonaga, Noël Tordo, Jonathan S Towner, Nikos Vasilakis, Viktor E Volchkov, Victoria Wahl-Jensen, Peter J Walker, Lin-Fa Wang, Arvind Varsani, Anna E Whitfield, F Murilo Zerbini, Jens H Kuhn
Botanical, mycological, zoological, and prokaryotic species names follow the Linnaean format, consisting of an italicized Latinized binomen with a capitalized genus name and a lower-case species epithet (e.g., Homo sapiens). Virus species names, however, do not follow a uniform format, and even when binomial, are not Linnaean in style. In this thought exercise, we attempted to convert all currently official names of species included in the virus family Arenaviridae and the virus order Mononegavirales to Linnaean binomials, and to identify and address associated challenges and concerns...
October 22, 2016: Systematic Biology
https://www.readbyqxmd.com/read/27783337/the-new-frontier-of-cardiac-computed-tomography-angiography-fractional-flow-reserve-and-stress-myocardial-perfusion
#11
REVIEW
Gianluca Pontone, Giuseppe Muscogiuri, Daniele Andreini, Andrea I Guaricci, Marco Guglielmo, Saima Mushtaq, Andrea Baggiano, Edoardo Conte, Virginia Beltrama, Andrea Annoni, Alberto Formenti, Elisabetta Mancini, Mark G Rabbat, Mauro Pepi
The increased number of patients with coronary artery disease (CAD) in developed countries is of great clinical relevance and involves a large burden of the healthcare system. The management of these patients is focused on relieving symptoms and improving clinical outcomes. Therefore the ideal test would provide the correct diagnosis and actionable information. To this aim, several non-invasive functional imaging modalities are usually used as gatekeeper to invasive coronary angiography (ICA), but their diagnostic yield remains low with limited accuracy when compared to obstructive CAD at the time of ICA or invasive fractional flow reserve (FFR)...
December 2016: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27774519/radiotherapy-changing-the-game-in-immunotherapy
#12
Sandra Demaria, C Norman Coleman, Silvia C Formenti
Immune checkpoint inhibitors are effective in cancer treatment. A pre-existing immune response demonstrated by significant pretreatment tumor lymphocytic infiltration is a pre-requisite for response. Within such infiltrated tumors, referred as "hot", immune checkpoint inhibitors rescue anti-tumor T cells activity. In contrast, "cold" tumors lack lymphocytic infiltration and are refractory to immunotherapy. Preclinical data show that radiotherapy sensitizes refractory tumors to immune checkpoint inhibitors by recruiting anti-tumor T cells...
June 2016: Trends in Cancer
https://www.readbyqxmd.com/read/27766553/glucocorticoid-induced-osteoporosis-pathophysiological-role-of-gh-igf-i-and-pth-vitamin-d-axes-treatment-options-and-guidelines
#13
Gherardo Mazziotti, Anna Maria Formenti, Robert A Adler, John P Bilezikian, Ashley Grossman, Emilia Sbardella, Salvatore Minisola, Andrea Giustina
Glucocorticoid-induced osteoporosis is the most frequent form of secondary osteoporosis caused by chronic exposure to glucocorticoid excess. Pathogenesis of glucocorticoid-induced osteoporosis is multifactorial including direct effects of glucocorticoids on bone cells and indirect effects of glucocorticoids on several neuroendocrine and metabolic pathways. Fragility fractures occur early in glucocorticoid-induced osteoporosis and anti-osteoporotic drugs along with calcium and vitamin D should be started soon after exposure to glucocorticoid excess...
October 20, 2016: Endocrine
https://www.readbyqxmd.com/read/27757313/trial-watch-immunotherapy-plus-radiation-therapy-for-oncological-indications
#14
REVIEW
Erika Vacchelli, Norma Bloy, Fernando Aranda, Aitziber Buqué, Isabelle Cremer, Sandra Demaria, Alexander Eggermont, Silvia Chiara Formenti, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Eric Tartour, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi
Malignant cells succumbing to some forms of radiation therapy are particularly immunogenic and hence can initiate a therapeutically relevant adaptive immune response. This reflects the intrinsic antigenicity of malignant cells (which often synthesize a high number of potentially reactive neo-antigens) coupled with the ability of radiation therapy to boost the adjuvanticity of cell death as it stimulates the release of endogenous adjuvants from dying cells. Thus, radiation therapy has been intensively investigated for its capacity to improve the therapeutic profile of several anticancer immunotherapies, including (but not limited to) checkpoint blockers, anticancer vaccines, oncolytic viruses, Toll-like receptor (TLR) agonists, cytokines, and several small molecules with immunostimulatory effects...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27717798/enterococcus-hirae-and-barnesiella-intestinihominis-facilitate-cyclophosphamide-induced-therapeutic-immunomodulatory-effects
#15
Romain Daillère, Marie Vétizou, Nadine Waldschmitt, Takahiro Yamazaki, Christophe Isnard, Vichnou Poirier-Colame, Connie P M Duong, Caroline Flament, Patricia Lepage, Maria Paula Roberti, Bertrand Routy, Nicolas Jacquelot, Lionel Apetoh, Sonia Becharef, Sylvie Rusakiewicz, Philippe Langella, Harry Sokol, Guido Kroemer, David Enot, Antoine Roux, Alexander Eggermont, Eric Tartour, Ludger Johannes, Paul-Louis Woerther, Elisabeth Chachaty, Jean-Charles Soria, Encouse Golden, Silvia Formenti, Magdalena Plebanski, Mutsa Madondo, Philip Rosenstiel, Didier Raoult, Vincent Cattoir, Ivo Gomperts Boneca, Mathias Chamaillard, Laurence Zitvogel
The efficacy of the anti-cancer immunomodulatory agent cyclophosphamide (CTX) relies on intestinal bacteria. How and which relevant bacterial species are involved in tumor immunosurveillance, and their mechanism of action are unclear. Here, we identified two bacterial species, Enterococcus hirae and Barnesiella intestinihominis that are involved during CTX therapy. Whereas E. hirae translocated from the small intestine to secondary lymphoid organs and increased the intratumoral CD8/Treg ratio, B. intestinihominis accumulated in the colon and promoted the infiltration of IFN-γ-producing γδT cells in cancer lesions...
September 28, 2016: Immunity
https://www.readbyqxmd.com/read/27707893/more-challenges-from-ebola-infection-of-the-central-nervous-system
#16
Gary Wong, Xiangguo Qiu, Yuhai Bi, Pierre Formenty, Armand Sprecher, Michael Jacobs, George F Gao, Gary Kobinger
Cases of relapsed Ebola virus disease involving symptoms in the central nervous system are reminiscent of our past observations with some nonhuman primates (NHPs) that survived acute Ebola virus infection. We document our findings in detail here and suggest that this phenomenon can be further investigated in NHPs.
October 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27679600/evaluation-of-coronary-plaque-characteristics-with-coronary-computed-tomography-angiography-in-patients-with-non-obstructive-coronary-artery-disease-a-long-term-follow-up-study
#17
Edoardo Conte, Andrea Annoni, Gianluca Pontone, Saima Mushtaq, Marco Guglielmo, Andrea Baggiano, Valentina Volpato, Cecilia Agalbato, Alice Bonomi, Fabrizio Veglia, Alberto Formenti, Cesare Fiorentini, Antonio L Bartorelli, Mauro Pepi, Daniele Andreini
AIMS: Recent studies suggested that even non-obstructive coronary artery disease (CAD) increases major cardiovascular adverse events (MACE) rate. Aim of this study was to evaluate whether coronary computed tomography angiography (CCTA) may detect specific plaque characteristics that may affect prognosis in patients with non-obstructive CAD. METHODS: We enrolled 245 patients who underwent CCTA between April 2004 and April 2007 for suspected CAD and were found to have non-obstructive CAD...
September 27, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27676043/tgf%C3%AE-superfamily-members-regulate-radiation-induced-in-situ-tumor-vaccination
#18
C Vanpouille-Box, S Formenti, S Demaria
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27676039/radiation-improves-systemic-anti-tumor-immunity-unleashed-by-a-novel-tlr9-agonist-sd-101
#19
K A Pilones, C Guiducci, S Demaria, S Formenti, E Golden
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675954/tumor-derived-exosomes-as-modulators-of-radiation-induced-anti-tumor-immunity
#20
J Diamond, J Chapman, B Ueberheide, S Formenti, S Demaria
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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