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Urinary microbiome

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https://www.readbyqxmd.com/read/29651696/diversity-of-the-midstream-urine-microbiome-in-adults-with-chronic-kidney-disease
#1
Holly Kramer, Gina Kuffel, Krystal Thomas-White, Alan J Wolfe, Kavitha Vellanki, David J Leehey, Vinod K Bansal, Linda Brubaker, Robert Flanigan, Julia Koval, Anuradha Wadhwa, Michael J Zilliox
PURPOSE: To examine the characteristics of the midstream urine microbiome in adults with stage 3-5 non-dialysis-dependent chronic kidney disease (CKD). METHODS: Patients with non-dialysis-dependent CKD (estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m2 ) and diuretic use were recruited from outpatient nephrology clinics. Midstream voided urine specimens were collected using the clean-catch method. The bacterial composition was determined by sequencing the hypervariable (V4) region of the bacterial 16S ribosomal RNA gene...
April 12, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29580847/parabens-and-measures-of-adiposity-among-adults-and-children-from-the-u-s-general-population-nhanes-2007-2014
#2
Lesliam Quirós-Alcalá, Jessie P Buckley, Meleah Boyle
BACKGROUND: Emerging experimental studies suggest that parabens could affect metabolism by altering the microbiome or signaling pathways involved in adipocyte differentiation. While human exposure to parabens is widespread, epidemiologic studies assessing the role of these chemicals on adiposity measures are scarce. OBJECTIVE: We examined associations of parabens with adiposity measures among adults and children in the U.S. general population. METHODS: We conducted covariate-adjusted linear and logistic regression models to examine associations between urinary biomarker concentrations of four parabens (butyl-BP, ethyl-EP, methyl-MP, and propyl paraben-PP) and measures of adiposity (obesity; body mass index, BMI or BMI z-score; and waist circumference) among 4730 adults (2007-2014) and 1324 children (2007-2012), participating in the National Health and Nutrition Examination Survey...
March 15, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29579080/variation-in-the-microbiome-of-the-urogenital-tract-of-chlamydia-free-female-koalas-phascolarctos-cinereus-with-and-without-wet-bottom
#3
Alistair R Legione, Jemima Amery-Gale, Michael Lynch, Leesa Haynes, James R Gilkerson, Fiona M Sansom, Joanne M Devlin
Koalas (Phascolarctos cinereus) are iconic Australian marsupials currently threatened by several processes, including infectious diseases and ecological disruption. Infection with Chlamydia pecorum, is considered a key driver of population decline. The clinical sign of 'wet bottom', a staining of the rump associated with urinary incontinence, is often caused by chlamydial urinary tract infections. However, wet bottom has been recorded in koalas free of C. pecorum, suggesting other causative agents in those individuals...
2018: PloS One
https://www.readbyqxmd.com/read/29539622/the-2017-update-of-the-german-clinical-guideline-on-epidemiology-diagnostics-therapy-prevention-and-management-of-uncomplicated-urinary-tract-infections-in-adult-patients-part-ii-therapy-and-prevention
#4
Jennifer Kranz, Stefanie Schmidt, Cordula Lebert, Laila Schneidewind, Falitsa Mandraka, Mirjam Kunze, Sina Helbig, Winfried Vahlensieck, Kurt Naber, Guido Schmiemann, Florian M Wagenlehner
BACKGROUND: We aimed to update the 2010 evidence- and consensus-based national clinical guideline on the diagnosis and management of uncomplicated urinary tract infections (UTIs) in adult patients. Results are published in 2 parts. Part 1 covers methods, the definition of patient groups, and diagnostics. This second publication focuses on treatment of acute episodes of cystitis and pyelonephritis as well as on prophylaxis of recurrent UTIs. MATERIALS AND METHODS: An interdisciplinary group consisting of 17 representatives of 12 medical societies and a patient representative was formed...
March 14, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29531289/microbial-metagenome-of-urinary-tract-infection
#5
Ahmed Moustafa, Weizhong Li, Harinder Singh, Kelvin J Moncera, Manolito G Torralba, Yanbao Yu, Oriol Manuel, William Biggs, J Craig Venter, Karen E Nelson, Rembert Pieper, Amalio Telenti
Urine culture and microscopy techniques are used to profile the bacterial species present in urinary tract infections. To gain insight into the urinary flora, we analyzed clinical laboratory features and the microbial metagenome of 121 clean-catch urine samples. 16S rDNA gene signatures were successfully obtained for 116 participants, while metagenome sequencing data was successfully generated for samples from 49 participants. Although 16S rDNA sequencing was more sensitive, metagenome sequencing allowed for a more comprehensive and unbiased representation of the microbial flora, including eukarya and viral pathogens, and of bacterial virulence factors...
March 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29506550/early-life-triclosan-exposure-and-child-adiposity-at-8-years-of-age-a-prospective-cohort-study
#6
Geetika Kalloo, Antonia M Calafat, Aimin Chen, Kimberly Yolton, Bruce P Lanphear, Joseph M Braun
BACKGROUND: Triclosan is an antimicrobial agent that may affect the gut microbiome and endocrine system to influence adiposity. However, little data from prospective studies examining prenatal and childhood exposures exist. We investigated the relationship between multiple, prospective early life measure of triclosan exposure and child adiposity.  METHODS: In a prospective cohort of 220 mother-child pairs from Cincinnati, OH (enrolled 2003-2006), we quantified triclosan in urine samples collected twice during pregnancy, annually from 1 to 5 years of age, and once at 8 years...
March 5, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29506183/characterization-of-metabolic-responses-to-healthy-diets-and-association-with-blood-pressure-application-to-the-optimal-macronutrient-intake-trial-for-heart-health-omniheart-a-randomized-controlled-study
#7
Ruey Leng Loo, Xin Zou, Lawrence J Appel, Jeremy K Nicholson, Elaine Holmes
Background: Interindividual variation in the response to diet is common, but the underlying mechanism for such variation is unclear. Objective: The objective of this study was to use a metabolic profiling approach to identify a panel of urinary metabolites representing individuals demonstrating typical (homogeneous) metabolic responses to healthy diets, and subsequently to define the association of these metabolites with improvement of risk factors for cardiovascular diseases (CVDs)...
March 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29492783/altered-gut-microbiome-promotes-proteinuria-in-mice-induced-by-adriamycin
#8
Qian Jiang, Xiwei He, Yuntao Zou, Yin Ding, Huang Li, Huimei Chen
Inflammation has recently been attributed to dysbiosis of the gut microbiome, which has been linked to proteinuria in chronic kidney disease. Since Adriamycin® (ADR) is widely used to induce proteinuria in mouse models, the aim of this study was to explore the potential effect of gut microbiome on this process. Both ADR resistant (C57BL/6) and susceptible (BALB/C) strains were part of the induced nephropathy with ADR injection. BALB/C mice significantly presented increased urinary albumin/creatinine ratio (UACR) with renal lesions in pathology, but C57BL/6 mice were absent from kidney damage...
February 28, 2018: AMB Express
https://www.readbyqxmd.com/read/29479554/molecular-identification-of-bacteria-in-intra-abdominal-abscesses-using-deep-sequencing
#9
Andrew Kozlov, Lorenzo Bean, Emilie V Hill, Lisa Zhao, Eric Li, Gary P Wang
Background: Intra-abdominal abscesses are localized collections of pus, which generally arise from a breach in the normal mucosal defense barrier that allows bacteria from gastrointestinal tract, and less commonly from the gynecologic or urinary tract, to induce inflammation, resulting in an infection. The microbiology of these abscesses is usually polymicrobial, associated with the primary disease process. However, the microbial identity, diversity and richness in intra-abdominal abscesses have not been well characterized, due in part to the difficulty in cultivating commensal organisms using standard culture-based techniques...
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29468401/the-role-of-the-genitourinary-microbiome-in-pediatric-urology-a-review
#10
REVIEW
Daniel Gerber, Catherine S Forster, Michael Hsieh
PURPOSE OF REVIEW: In this review, we highlight the effects of the microbiome on urologic diseases that affect the pediatric patient. RECENT FINDINGS: Perturbations in the urinary microbiome have been shown to be associated with a number of urologic diseases affecting children, namely urinary tract infection, overactive bladder/urge urinary incontinence, and urolithiasis. Recently, improved cultivation and sequencing technologies have allowed for the discovery of a significant and diverse microbiome in the bladder, previously assumed to be sterile...
February 22, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29460923/microbiota-bacteriophage-diversity-in-the-urinary-microbiome
#11
Louise Stone
No abstract text is available yet for this article.
February 20, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29455238/a-blinded-observational-cohort-study-of-the-microbiological-ecology-associated-with-pyuria-and-overactive-bladder-symptoms
#12
Kiren Gill, Ryoon Kang, Sanchutha Sathiananthamoorthy, Rajvinder Khasriya, James Malone-Lee
INTRODUCTION AND HYPOTHESIS: This study sought to characterise the microbial ecology of the lower urinary tract in patients with symptoms of overactive bladder (OAB) using culture of the urinary urothelial cell sediment. The pathological significance of the microbiome was assessed through its relationship with known urothelial inflammatory markers and patient reported symptoms. METHODS: Adult female patients with OAB symptoms and asymptomatic controls were assessed at 12 study visits scheduled every 4 weeks...
February 17, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29378882/bacteriophages-of-the-urinary-microbiome
#13
Taylor Miller-Ensminger, Andrea Garretto, Jonathon Brenner, Krystal Thomas-White, Adriano Zambom, Alan J Wolfe, Catherine Putonti
Bacterial viruses (bacteriophages) play a significant role in microbial community dynamics. Within the human gastrointestinal tract, for instance, associations amongst bacteriophages (phages), microbiota stability, and human health have been discovered. In contrast to the gastrointestinal tract, the phages associated with the urinary microbiota are largely unknown. Preliminary metagenomic surveys of the urinary virome indicate a rich diversity of novel lytic phage sequences, at an abundance far outnumbering eukaryotic viruses...
January 29, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29323625/catheter-associated-urinary-tract-infections-in-persons-with-neurogenic-bladders
#14
Todd A Linsenmeyer
This review is based on the author's Donald Munro Lecture given at the annual conference of the Academy of Spinal Cord Injury Professionals in New Orleans, LA. Indwelling catheters play an important role in bladder management following SCI for many individuals with neurogenic bladders. There is an increased risk of UTI compared to other types of bladder management with indwelling urethral catheters but not SP catheters. To minimize the risk of symptomatic UTI, the following steps are essential: prevent bladder wall distention and resulting ischemia, maintain colonization with "good" bacteria, and prevent bladder stones...
March 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29240375/an-integrative-review-of-current-research-on-the-role-of-the-female-urinary-microbiota-in-overactive-bladder-symptoms
#15
REVIEW
Kimberly J Angelini
This integrative review explores current evidence on microbiota of the female urinary tract as it relates to overactive bladder (OAB) symptoms. Six articles were identified for review. Findings suggest a possible link between the female urinary microbiome and OAB symptom presentation.
March 2017: Urologic Nursing
https://www.readbyqxmd.com/read/29230385/urinary-microbiome-and-psychological-factors-in-women-with-overactive-bladder
#16
Peng Wu, Yang Chen, Jie Zhao, Guihao Zhang, Jiawei Chen, Junpeng Wang, Huijian Zhang
Objectives: Emerging evidence indicates that alterations to the urinary microbiome are related to lower urinary tract symptoms. Overactive bladder (OAB) is a common disorder with complex etiologies and usually accompanied by psychological diseases. More information concerning the urinary microbiome and psychological factors in OAB is required. The aim of this study was to characterize the female urinary microbiome associated with OAB and investigate the relationships between urinary microbiome and psychological factors...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29202045/adaptation-in-a-fibronectin-binding-autolysin-of-staphylococcus-saprophyticus
#17
Tatum D Mortimer, Douglas S Annis, Mary B O'Neill, Lindsey L Bohr, Tracy M Smith, Hendrik N Poinar, Deane F Mosher, Caitlin S Pepperell
Human-pathogenic bacteria are found in a variety of niches, including free-living, zoonotic, and microbiome environments. Identifying bacterial adaptations that enable invasive disease is an important means of gaining insight into the molecular basis of pathogenesis and understanding pathogen emergence. Staphylococcus saprophyticus , a leading cause of urinary tract infections, can be found in the environment, food, animals, and the human microbiome. We identified a selective sweep in the gene encoding the Aas adhesin, a key virulence factor that binds host fibronectin...
November 2017: MSphere
https://www.readbyqxmd.com/read/29152146/breast-tissue-oral-and-urinary-microbiomes-in-breast-cancer
#18
Hannah Wang, Jessica Altemus, Farshad Niazi, Holly Green, Benjamin C Calhoun, Charles Sturgis, Stephen R Grobmyer, Charis Eng
It has long been proposed that the gut microbiome contributes to breast carcinogenesis by modifying systemic estrogen levels. This is often cited as a possible mechanism linking breast cancer and high-fat, low-fiber diets as well as antibiotic exposure, associations previously identified in population-based studies. More recently, a distinct microbiome has been identified within breast milk and tissue, but few studies have characterized differences in the breast tissue microbiota of patients with and without cancer, and none have investigated distant body-site microbiomes outside of the gut...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29089606/the-inflammatory-microenvironment-and-microbiome-in-prostate-cancer-development
#19
REVIEW
Karen S Sfanos, Srinivasan Yegnasubramanian, William G Nelson, Angelo M De Marzo
Chronic inflammation promotes the development of several types of solid cancers and might contribute to prostate carcinogenesis. This hypothesis partly originates in the frequent observation of inflammatory cells in the prostate microenvironment of adult men. Inflammation is associated with putative prostate cancer precursor lesions, termed proliferative inflammatory atrophy. Inflammation might drive prostate carcinogenesis via oxidative stress and generation of reactive oxygen species that induce mutagenesis...
January 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29061990/tmao-is-associated-with-mortality-impact-of-modestly-impaired-renal-function
#20
Eke G Gruppen, Erwin Garcia, Margery A Connelly, Elias J Jeyarajah, James D Otvos, Stephan J L Bakker, Robin P F Dullaart
Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND participants to examine associations of plasma TMAO with all-cause mortality. After median follow-up of 8.3 years in 5,469 participants, 322 subjects died. TMAO was positively associated with age, body mass index, type 2 diabetes mellitus and inversely with estimated glomerular filtration rate (eGFRcreatcysC)(all P < 0...
October 23, 2017: Scientific Reports
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