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https://www.readbyqxmd.com/read/29754138/lateral-semicircular-canal-osteoma-presenting-as-chronic-postaural-fistula
#1
Charn Gill, Jameel Muzaffar, Raghu Sampath Kumar, Richard Irving
Temporal bone osteoma is an unusual pathology which can occur by birth or can be acquired and mostly involves the tympanomastoid segment of the temporal bone. Osteomas arising from the otic capsule are extremely rare, and there has been only one other report of a lateral semicircular canal osteoma in the literature. We report a similar case of an acquired lateral canal osteoma which presented as a chronic postaural fistula in an ear previously operated for paediatric cholesteatoma.
May 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29728172/hearing-loss-in-pediatric-temporal-bone-fractures-evaluating-two-radiographic-classification-systems-as-prognosticators
#2
A Bhindi, L Carpineta, B Al Qassabi, S Waissbluth, R Ywakim, J J Manoukian, L H P Nguyen
INTRODUCTION: Temporal bone fractures (TBF) are traditionally classified by their angle of fracture relative to the petrous ridge, and more recently by whether or not they violate the otic-capsule. This study compared rates of hearing loss (HL) and signs of otologic dysfunction among fracture types of both classification systems, within the pediatric population. METHODS: Pediatric patients were retrospectively characterized from a previously identified cohort of TBF patients, diagnosed from 2000 to 2014...
June 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29703055/treatment-of-ramsay-hunt-s-syndrome-with-multiple-cranial-nerve-involvement-and-severe-dysphagia-a-case-report
#3
Jong Min Kim, Zeeihn Lee, Seungwoo Han, Donghwi Park
RATIONALE: Ramsay-Hunt's syndrome (RHS) is a disorder characterized by facial paralysis, herpetic eruptions on the auricle, and otic pain due to the reactivation of latent varicella zoster virus in the geniculate ganglion. A few cases of multiple cranial nerve invasion including the vestibulocochlear nerve, glossopharyngeal nerve and vagus nerve have been reported. However, there has been no report about RHS with delayed onset multiple cranial nerve involvement causing severe aspiration, and a clinical course that improved after more than one year of dysphagia rehabilitation and percutaneous endoscopic gastrostomy (PEG)...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29696957/-turicella-otitidis-contributions-to-its-role-in-the-etiology-of-ear-infections
#4
M De Frutos, L López-Urrutia, R Aragón, A M Vegas, M Vázquez, J M Eiros Bouza
OBJECTIVE: Turicella otitidis is a gram-positive bacillus coryneforme described, after 16S RNA sequencing, in 1994 by Funke et al as a microorganism involved in otitis media, and it is in health conditions a habitual colonizer of the external auditory canal. Since its description, more than twenty years ago, few cases of otitis related to or directly attributed to this microorganism have been published. METHODS: Description of a case of mastoiditis that required surgery and other cases of otic pathology in which T...
April 26, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29669196/development-of-the-human-incus-with-special-reference-to-the-detachment-from-the-chondrocranium-to-be-transferred-into-the-middle-ear
#5
Jose Francisco Rodríguez-Vázquez, Masahito Yamamoto, Shinichi Abe, Yukio Katori, Gen Murakami
The mammalian middle ear represents one of the most fundamental features defining this class of vertebrates. However, the origin and the developmental process of the incus in the human remains controversial. The present study seeks to demonstrate all the steps of development and integration of the incus within the middle ear. We examined histological sections of 55 human embryos and foetuses at 6 to 13 weeks of development. At 6 weeks of development (16 Carnegie Stage), the incus anlage was found to be lateral to this vein at the cranial end of the first pharyngeal arch...
April 18, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29669195/early-fetal-development-of-the-otic-and-pterygopalatine-ganglia-with-special-reference-to-the-topographical-relationship-with-the-developing-sphenoid-bone
#6
Masahito Yamamoto, Kwang Ho Cho, Gen Murakami, Shinichi Abe, Jose Francisco Rodríguez-Vázquez
The otic and pterygopalatine ganglia are located close to the greater wing (alisphenoid) of the sphenoid bone and many researchers have noted nerves connecting these ganglia in human embryos. The greater wing (alisphenoid) arises from the cartilaginous ala temporalis independently of the lesser wing, but no topographical changes between this cartilage and nerve elements have been demonstrated. We examined histological sections of 20 human embryos and fetuses from 6 to 15 weeks of development (WD). At 6 WD, the ala temporalis, the alar process and ganglia were all identified as a single, undifferentiated cell mass...
April 18, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29664150/conductive-hearing-loss-in-four-dogs-associated-with-the-use-of-ointment-based-otic-medications
#7
Lynette K Cole, Päivi J Rajala-Schultz, Gwendolen Lorch
BACKGROUND: Hearing loss (HL) is classified as conductive when sound transmission is compromised in the ear canal or middle ear, or sensorineural when there is an abnormality of the receptor cells of the cochlea or auditory pathway. Hearing in dogs is evaluated using the brainstem auditory evoked response (BAER) test. HYPOTHESIS/OBJECTIVES: Our objective was to characterize BAER findings pre- and post-ear flushing in four dogs with acute HL following application of an ointment-based otic medication containing betamethasone, clotrimazole and gentamicin in a mineral oil-based system containing a plasticized hydrocarbon gel...
April 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29659300/otic-drug-delivery-systems-formulation-principles-and-recent-developments
#8
Xu Liu, Mingshuang Li, Hugh Smyth, Feng Zhang
Disorders of the ear severely impact the quality of life of millions of people, but the treatment of these disorders is an on-going but often overlooked challenge particularly in terms of formulation design and product development. The prevalence of ear disorders has spurred significant efforts to develop new therapeutic agents, but perhaps less innovation has been applied to new drug delivery systems to improve the efficacy of ear disease treatments. This review provides a brief overview of physiology, major diseases, and current therapies used via the otic route of administration...
April 16, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29659020/surgical-management-of-chronic-otitis-secondary-to-craniomandibular-osteopathy-in-three-west-highland-white-terriers
#9
L Beever, F Swinbourne, S L Priestnall, G Ter Haar, D J Brockman
Three West Highland white terriers were presented for investigation of left-sided para-aural abscessation. CT revealed chronic otitis media with extensive osseous proliferation surrounding the horizontal and vertical ear canals contiguous with the expanded temporal bone, consistent with a unilateral variant of craniomandibular osteopathy. A left total ear canal ablation with lateral bulla osteotomy was performed in all dogs. An ultrasonic bone curette (Sonopet; Stryker) proved useful when removing the osseous proliferation in two dogs...
April 16, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29595579/prevention-of-otic-barotrauma-in-aviation-a-systematic-review
#10
Peter Ryan, Alexander Treble, Nirmal Patel, Nicholas Jufas
OBJECTIVE: To conduct a systematic review of the published evidence relating to the prevention of otic barotrauma in aviation. In particular, this review sought to identify procedures, techniques, devices, and medications for the prevention of otic barotrauma as well as evaluate the evidence relating to their efficacy. DATA SOURCES: Ten databases including Embase, MEDLINE, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials were searched using the full historical range...
March 27, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29587787/pediatric-langerhans-cell-histiocytosis-of-the-temporal-bone-clinical-and-imaging-studies-of-27-cases
#11
Hui Zheng, Zhengrong Xia, Wenjun Cao, Yun Feng, Shuxian Chen, Yu-Hua Li, Deng-Bin Wang
BACKGROUND: We aimed to evaluate the clinical and imaging presentations of Langerhans cell histiocytosis (LCH) in the pediatric temporal bone. METHODS: This retrospective study included 27 pediatric cases with pathological confirmed LCH of the temporal bone. The clinical and imaging features of the cases were analyzed. The involvement of ossicular chain and otic capsule was also evaluated. RESULTS: A total of 38 lesions (27 cases) with 11 bilateral involvement were identified...
March 27, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29567655/3d-deep-learning-angiography-3d-dla-from-c-arm-conebeam-ct
#12
J C Montoya, Y Li, C Strother, G-H Chen
BACKGROUND AND PURPOSE: Deep learning is a branch of artificial intelligence that has demonstrated unprecedented performance in many medical imaging applications. Our purpose was to develop a deep learning angiography method to generate 3D cerebral angiograms from a single contrast-enhanced C-arm conebeam CT acquisition in order to reduce image artifacts and radiation dose. MATERIALS AND METHODS: A set of 105 3D rotational angiography examinations were randomly selected from an internal data base...
March 22, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29551350/efficacy-and-safety-of-eberconazole-1-otic-solution-compared-to-clotrimazole-1-solution-in-patients-with-otomycosis
#13
Blanca Regina de la Paz Cota, Pedro Pablo Cepero Vega, Juan José Matus Navarrete, Gerardo Efrain Aguado Mulgado, José Juan Narváez Huerta, Enrique Lamadrid Bautista, Epifanio Fiscal Chauteco
PURPOSE: To demonstrate non-inferiority of eberconazole 1% otic solution to clotrimazole 1% solution, and to compare their safety profiles in the treatment of otomycosis. MATERIALS AND METHODS: Multicenter, randomized, double-blind, active treatment-controlled phase 3 clinical trial. One hundred and ninety patients with diagnosis of otomycosis were randomly assigned to eberconazole 1% otic solution or clotrimazole 1% solution. RESULTS: Baseline characteristics were comparable between both groups for age, gender, ethnicity, and clinical variables...
March 6, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29535354/fluorescent-polydopamine-nanoparticles-as-a-probe-for-zebrafish-sensory-hair-cells-targeted-in-vivo-imaging
#14
Gyo Eun Gu, Chul Soon Park, Hyun-Ju Cho, Tai Hwan Ha, Joonwon Bae, Oh Seok Kwon, Jeong-Soo Lee, Chang-Soo Lee
Fluorescent polydopamine nanoparticles (FPNPs) are prepared via the ethylenediamine (EDA)-induced degradation of as-prepared non-fluorescent polydopamine (PDA) and used for targeted bioimaging. The reductive treatment of PDA in the presence of EDA yields fluorescent precipitates, inspiring us to seek various biological approaches to preparing FPNPs with excellent optical and biocompatible properties. Moreover, we firstly found that FPNPs selectively label neuromast hair cells in the lateral line of zebrafish, their applications as a reliable fluorescent indicator to investigate the neuromast hair cells, to in turn determine the viability of hair cells, was demonstrated...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29523978/pacap-and-its-role-in-primary-headaches
#15
REVIEW
Lars Edvinsson, János Tajti, Levente Szalárdy, László Vécsei
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observed in the sensory trigeminal ganglion (TG), in the parasympathetic sphenopalatine (SPG) and otic ganglia (OTG), and in the brainstem trigeminocervical complex. Immunohistochemistry has shown PACAP-38 in numerous cell bodies of SPG/OTG, co-stored with vasoactive intestinal peptide (VIP), nitric oxide synthase (NOS) and, to a minor degree, with choline acetyltransferase...
March 9, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29520762/cooperation-of-sall4-and-sox8-transcription-factors-in-the-regulation-of-the-chicken-sox3-gene-during-otic-placode-development
#16
Yu Okamoto, Naoko Nishimura, Kazunari Matsuda, Deshani C Ranawakage, Yusuke Kamachi, Hisato Kondoh, Masanori Uchikawa
To elucidate the transcriptional regulation that underlies specification of the otic placode, we investigated the Sox3 downstream enhancer Otic1 of the chicken, the activity of which is restricted to and distributed across the entire otic placode. The 181-bp Otic1 enhancer sequence was dissected into a 68-bp minimal activating sequence, which exhibited dimer enhancer activity in the otic placode and cephalic neural crest, and this was further reduced to a 25-bp Otic1 core sequence, which also showed octamer enhancer activity in the same regions...
April 2018: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/29502728/medical-management-of-otosclerosis
#17
REVIEW
Norma de Oliveira Penido, Andy de Oliveira Vicente
Otosclerosis/otospongiosis is a primary osteodystrophy of the otic capsule that affects genetically predisposed individuals and leads to progressive hearing loss. Diagnosis is usually clinical, based on the findings of anamnesis, physical examination, and audiometric evaluation. However, high-resolution computed tomography scan and MRI have played an important role in the diagnosis and therapeutic approach of otosclerosis and in assisting in the differential diagnosis. The therapeutic approach is aimed at preventing, or at least minimizing, disease progression while attempting to restore hearing...
April 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29502723/otosclerosis-from-genetics-to-molecular-biology
#18
REVIEW
Thomas A Babcock, Xue Zhong Liu
Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.
April 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29475374/radial-spoke-proteins-regulate-otolith-formation-during-early-zebrafish-development
#19
Xiao Han, Haibo Xie, Yadong Wang, Chengtian Zhao
Radial spokes are structurally conserved, macromolecular complexes that are essential for the motility of 9 + 2 motile cilia. In Chlamydomonas species, mutations in radial spoke proteins result in ciliary motility defects. However, little is known about the function of radial spoke proteins during embryonic development. Here, we investigated the role of a novel radial spoke protein, leucine-rich repeat containing protein 23 (Lrrc23), during zebrafish embryonic development. Mutations in lrrc23 resulted in a selective otolith formation defect during early ear development...
February 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29466046/impact-of-synthetic-canine-cerumen-on-in-vitro-penetration-of-auricular-skin-of-dogs-by-florfenicol-terbinafine-and-betamethasone-acetate
#20
Sarah Ehling, Ronald E Baynes, Wolfgang Bäumer
OBJECTIVE To determine the pharmacokinetics of florfenicol, terbinafine, and betamethasone acetate after topical application to canine auricular skin and the influence of synthetic canine cerumen on pharmacokinetics. SAMPLE Auricular skin from 6 euthanized shelter dogs (3 females and 3 neutered males with no visible signs of otitis externa). PROCEDURES Skin adjacent to the external opening of the ear canal was collected and prepared for use in a 2-compartment flow-through diffusion cell system to evaluate penetration of an otic gel containing florfenicol, terbinafine, and betamethasone acetate over a 24-hour period...
March 2018: American Journal of Veterinary Research
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