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Juvenile idiopathic arthritis pulmonary

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https://www.readbyqxmd.com/read/27686328/value-and-usability-of-unpublished-data-sources-for-systematic-reviews-and-network-meta-analyses
#1
Nicholas James Anthony Halfpenny, Joan Mary Quigley, Juliette Catherine Thompson, David Alexander Scott
Peer-reviewed publications and conference proceedings are the mainstay of data sources for systematic reviews and network meta-analyses (NMA), but access to informative unpublished data is now becoming commonplace. To explore the usefulness of three types of 'grey' literature-clinical trials registries, clinical study reports and data from regulatory authorities-we conducted four case studies. The reporting of outcome data in peer-reviewed publications, the clinical trials registries and the clinical study reports for two clinical trials-one in melanoma, one in juvenile idiopathic arthritis (JIA)-was examined...
September 29, 2016: Evidence-based Medicine
https://www.readbyqxmd.com/read/27283334/long-term-outcome-in-juvenile-onset-mixed-connective-tissue-disease-a-nationwide-norwegian-study
#2
Siri Opsahl Hetlevik, Berit Flatø, Marite Rygg, Ellen Berit Nordal, Cathrine Brunborg, Helene Hetland, Vibke Lilleby
OBJECTIVES: To describe the characteristics, outcome and predictive factors of juvenile mixed connective tissue disease (JMCTD) in a nationwide cohort of patients. METHODS: We examined 55 patients with JMCTD after a mean disease duration of 16.2 years (SD 10.0). Patients were registered according to Kasukawa's criteria. Remission criteria were defined according to those for juvenile idiopathic arthritis, plus absence of cytopenia, myositis, progressive sclerodactyly, lung and oesophageal manifestations...
June 9, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27156925/real-life-practice-of-methotrexate-toxicity-monitoring-in-juvenile-idiopathic-arthritis-in-germany-switzerland-and-austria-results-of-a-cross-sectional-assessment-conducted-in-2012
#3
Manas K Akmatov, Melanie Stumme, Frank Pessler
OBJECTIVES: Methotrexate (MTX) is used at low doses to treat rheumatologic disorders in the paediatric age group. Toxicity is observed despite the low doses used. Even though recommendations for monitoring of early signs of toxicity exist in many countries, real-life practice may vary. We therefore assessed current practice in Germany, Switzerland and Austria. METHODS: A 22-item questionnaire regarding practices of monitoring MTX therapy was sent by email to all members of the Society for Paediatric and Adolescent Rheumatology (GKJR, n=224)...
May 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27093271/exhaled-breath-analysis-in-childhood-rheumatic-disorders-a-longitudinal-study
#4
N Hendel, M K Akmatov, J Hamel, C Vogelberg, F Pessler
We aimed to evaluate the fraction of exhaled nitric oxide (FENO50) and deaerated exhaled breath condensate pH (dEBCpH) as non-invasive markers of subclinical airway inflammation in pediatric patients with rheumatologic disorders. We determined FENO50 and dEBCpH in a prospective study spanning at least 12 months, comprising 85 pediatric patients with rheumatologic disorders, including juvenile idiopathic arthritis (JIA, n  =  63), chronic recurrent multifocal osteomyelitis (CRMO, n  =  6), systemic lupus erythematosus (SLE, n  =  3), juvenile dermatomyositis (JDM, n  =  1) and other rheumatic disorders (n  =  12)...
June 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/26768831/respiratory-complications-of-the-rheumatological-diseases-in-childhood
#5
REVIEW
Anne E Richardson, Kishore Warrier, H Vyas
Pleuropulmonary manifestations of rheumatological diseases are rare in children but pose a significant risk to overall morbidity and mortality. We have reviewed the literature to provide an overview of the respiratory complications of the commonest rheumatological diseases to occur in children (juvenile systemic lupus erythematosus, scleroderma, juvenile dermatomyositis, mixed connective tissue disease, granulomatosis with polyangitis and juvenile idiopathic arthritis). Pulmonary function testing in these patients can be used to refine the differential diagnosis and establish disease severity, but also has a role in ongoing monitoring for respiratory complications...
August 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/25613167/adult-onset-still-s-disease-pathogenesis-clinical-manifestations-and-new-treatment-options
#6
REVIEW
Sabeeda Kadavath, Petros Efthimiou
Adult-onset Still's disease (AOSD), a systemic inflammatory disorder, is often considered a part of the spectrum of the better-known systemic-onset juvenile idiopathic arthritis, with later age onset. The diagnosis is primarily clinical and necessitates the exclusion of a wide range of mimicking disorders. AOSD is a heterogeneous entity, usually presenting with high fever, arthralgia, skin rash, lymphadenopathy, and hepatosplenomegaly accompanied by systemic manifestations. The diagnosis is clinical and empirical, where patients are required to meet inclusion and exclusion criteria with negative immunoserological results...
February 2015: Annals of Medicine
https://www.readbyqxmd.com/read/25152021/long-term-evaluation-of-cardiac-function-in-juvenile-idiopathic-arthritis-under-anti-tnf-therapy
#7
Alessandro C Lianza, Nadia E Aikawa, Julio C B Moraes, Gabriela N Leal, Samira S Morhy, Jose L Andrade, Eloisa Bonfa, Clovis A Silva
OBJECTIVES: This paper aims to perform global assessment of long-term cardiac function in juvenile idiopathic arthritis (JIA) patients under TNF blockage therapy. METHODS: Twenty-five polyarticular-course JIA patients pre-anti-TNF and 22 healthy controls underwent conventional/tissue Doppler echocardiography and cardiac biomarkers measurements (N-terminal pro-brain natriuretic peptide [NT-pro-BNP] and troponin T) at baseline (BL). Twenty-one JIA patients completed six evaluations during two consecutive years...
September 2014: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/24974758/-adult-onset-stills-disease-a-difficult-path-to-diagnosis-through-fever-and-effusions-of-unknown-origin
#8
Jana Malegová, Lukáš Koten, Pavel Horák
Fever of unknown origin, pleural and pericardial effusions can be caused by a variety of independent agents. On the other hand, we can identify a common causative condition in other cases. Infectious diseases, malignancies and autoimmune diseases are the most common etiological factors. Considering the pleural and pericardial effusion, we also have to think of cardiovascular and pulmonary diseases. The basis of every diagnostic process is thorough medical history and detailed clinical examination followed by laboratory and imaging methods...
May 2014: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/24892681/life-threatening-pneumonitis-complicating-low-dose-methotrexate-treatment-for-juvenile-idiopathic-arthritis-in-a-child
#9
Yuan-Chang Liu, Yu-Ling Tu, Ren-Chin Wu, Jing-Long Huang, Tsung-Chieh Yao
Methotrexate, a drug commonly used to treat juvenile idiopathic arthritis (JIA), has been reported to cause interstitial pneumonitis as a rare complication in adults with rheumatoid arthritis. Only 1 suspicious case of methotrexate pneumonitis in a child with JIA has been reported in 1998, though with no histopathologic proof. Given its rarity and nonspecific presenting symptoms, diagnosis may be challenging, and a life-threatening illness can occur without a high index of suspicion, as illustrated by this report of a 13-year-old girl with JIA who developed fever, nonproductive cough, and dyspnea as presenting features of interstitial pneumonitis after 1 year of methotrexate therapy...
June 2014: Pediatric Emergency Care
https://www.readbyqxmd.com/read/24876985/a-case-of-blau-syndrome
#10
Krati Chauhan, Clement Michet
We present a case of systemic granulomatous disorder/Blau syndrome. A patient was seen at our clinic with a diagnosis of Juvenile Idiopathic Arthritis (JIA). He was diagnosed with polyarticular JIA when he was two years old, at that time primary manifestations included inflammation of the hand and wrist joints bilaterally, later he developed ocular symptoms, which were attributed to JIA. He had liver, skin, pulmonary manifestations, and diagnostic workup including biopsy revealed granulomatous inflammation of these sites...
2014: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/24581387/a-novel-therapeutic-approach-in-pulmonary-arterial-hypertension-as-a-complication-of-adult-onset-still-s-disease-targeting-il-6
#11
REVIEW
Sabeeda Kadavath, Ekaterini Zapantis, Ronald Zolty, Petros Efthimiou
Adult-onset Still's Disease (AOSD), often though as the adult variant of systemic juvenile idiopathic arthritis (JIA), has an incidence of 1-3 cases per 1 million. Cardinal manifestations include fever, arthritis, skin rash, sore throat, hepatosplenomegaly and lymphadenopathy. Prolongation in diagnosing this disease results from its similarity to infectious, malignant and rheumatic diseases and lack of biomarkers. Pulmonary arterial hypertension (PAH) is a rare pulmonary complication of AOSD, and we are aware of only six cases reported in literature to date...
March 2014: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/24493318/spirometric-evaluation-in-juvenile-idiopathic-arthritis-data-from-eastern-india
#12
Md Mahboob Alam, Biman Ray, Sumantra Sarkar, Oona Mandal, Rakesh Mondal, Avijit Hazra, Niloy Kumar Das
OBJECTIVE: To evaluate lung function in juvenile idiopathic arthritis (JIA) patients. METHODS: This was a case control study carried out at Institute of Post-Graduate Medical Education & Research, Kolkata, involving JIA patients between 5 and 12 y. They were diagnosed and classified on the basis of International League of Associations for Rheumatology (ILAR) criteria and compared with same number of age, sex, height and weight matched controls. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, forced expiratory flow between 25 and 75% of vital capacity (FEF25-75%) and peak expiratory flow rate (PEFR) of cases were compared to those of matched controls...
October 2014: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/23699161/close-family-ties-familial-interstitial-lung-disease-secondary-to-familial-juvenile-idiopathic-arthritis
#13
Charo Francisco
SESSION TYPE: ILD Global Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Interstitial lung disease (ILD) includes a large, heterogeneous group of mostly rare pulmonary conditions that cause derangements of the alveolar walls and loss of functional alveolar capillary units, consisting of both known and unknown causes that share common histological features. It is influenced by several factors such as host susceptibility, genetics and environmental aspects. Familial ILD is identified by verifying in two or more members of the same family...
October 1, 2012: Chest
https://www.readbyqxmd.com/read/23139240/pulmonary-hypertension-and-other-potentially-fatal-pulmonary-complications-in-systemic-juvenile-idiopathic-arthritis
#14
Yukiko Kimura, Jennifer E Weiss, Kathryn L Haroldson, Tzielan Lee, Marilynn Punaro, Sheila Oliveira, Egla Rabinovich, Meredith Riebschleger, Jordi Antón, Peter R Blier, Valeria Gerloni, Melissa M Hazen, Elizabeth Kessler, Karen Onel, Murray H Passo, Robert M Rennebohm, Carol A Wallace, Patricia Woo, Nico Wulffraat
OBJECTIVE: Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and arthritis, for which interleukin-1 (IL-1) and IL-6 inhibitors appear to be effective treatments. Pulmonary arterial hypertension (PAH), interstitial lung disease (ILD), and alveolar proteinosis (AP) have recently been reported with increased frequency in systemic JIA patients. Our aim was to characterize and compare systemic JIA patients with these complications to a larger cohort of systemic JIA patients...
May 2013: Arthritis Care & Research
https://www.readbyqxmd.com/read/22409955/lung-function-in-children-and-adolescents-with-juvenile-idiopathic-arthritis-during-long-term-treatment-with-methotrexate-a-retrospective-study
#15
Christoph Leiskau, Angelika Thon, Monika Gappa, Frank Dressler
OBJECTIVES: Methotrexate may cause severe adverse pulmonary side-effects in adults with rheumatoid arthritis. Our aim was to examine the long-term effect of MTX on lung function in patients with juvenile idiopathic arthritis (JIA). METHODS: We retrospectively reviewed the charts of all 68 patients with JIA treated with MTX at our centre over a 14-year period. Results of annual pulmonary function tests (PFT) were compared using paired t-tests adjusted by Bonferroni correction and by linear regression analysis...
March 2012: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/21684670/lung-involvement-in-rheumatologic-diseases-in-children
#16
A Quezada, S Ramos, M Garcia, X Norambuena, D Pavon
BACKGROUND: Lung involvement in rheumatologic disease in children has been described with low frequency. OBJECTIVE: To describe the lung function test and the radiological findings in a group of paediatric patients with rheumatologic diseases. METHODS: Descriptive study. Pulmonary function was evaluated with spirometry, carbon monoxide diffusing capacity, blood arterial gas at rest and post exercise in addition to chest radiography and high resolution computed tomography were performed in children with rheumatologic disease...
March 2012: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/21291842/juvenile-idiopathic-arthritis-presenting-with-prolonged-fever
#17
Tzu-Lin Yeh, Fu-Yuan Huang, Shyh-Dar Shyur, Tien-Ling Chen, Chyou-Shen Lee, Daniel Tsung-Ning Huang
BACKGROUND/PURPOSE: Systemic-onset juvenile idiopathic arthritis (s-JIA) is a systemic disease often accompanied by a fever. We examined 16 patients with s-JIA and reported the clinical manifestations, laboratory data, treatments and outcomes. METHODS: From 1984 to 2007, 16 children (aged 1-16 years), who were diagnosed as having s-JIA, were admitted to the Mackay Memorial Hospital in Taiwan. We retrospectively reviewed their medical charts. RESULTS: There were nine boys and seven girls, with mean age of onset of 7...
June 2010: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/20932725/-osteoarticular-tuberculosis-a-differential-diagnosis-of-idiopathic-juvenile-arthritis
#18
C Guillou-Debuisson, S Salanne, C Maréchal, E Laporte, I Claudet, E Grouteau
UNLABELLED: We report a case of extrapulmonary tuberculosis with oligoarthritis and synovitis in a 6-year-old girl with undiagnosed disseminated tuberculosis. CLINICAL CASE: The child, adopted from Ethiopia, was admitted to the pediatric rheumatology unit for suspected idiopathic juvenile arthritis. She presented with clinical signs of subacute arthritis of the right knee. Joint symptoms began insidiously and followed a short period of fever and pain in the right hip...
November 2010: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/20658239/assessment-of-cardiac-and-pulmonary-function-in-children-with-juvenile-idiopathic-arthritis
#19
Eman A M Alkady, Hatem A R Helmy, Aliaë A R Mohamed-Hussein
Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disorder of childhood. It is a group of diseases characterized by chronic synovitis and associated with many extra-articular manifestations including cardiac and pulmonary involvement. Cardiac involvement as pericarditis, myocarditis and valvular disease is common in JIA. There are, however, few descriptions concerning systolic and diastolic functions of the left ventricle (LV) and the development of lung disease in children with JIA. The study was carried out to detect the cardiac and pulmonary involvement and to study the systolic and diastolic function of the left ventricle in a group of children with juvenile idiopathic arthritis...
January 2012: Rheumatology International
https://www.readbyqxmd.com/read/20407818/clinical-characteristics-and-outcomes-of-patients-with-idiopathic-inflammatory-myopathies-from-jordan-1996-2009
#20
Khader N Mustafa, Said S Dahbour
To describe demographic characteristics, clinical features and outcome of Jordanian patients with idiopathic inflammatory myopathies (IIM), a retrospective chart review of all patients diagnosed with IIM at Jordan University Hospital between 1996 and 2009 was carried out. Thirty patients with IIM were identified. Female to male ratio was 1.7:1, with mean age at diagnosis 34.3 ± 9.2 (10-72) years with bimodal presentation at 21 and 49 years and a mean follow-up of 6.5 ± 5.7 years. Eleven patients had polymyositis (PM); 19 patients had dermatomyositis (DM); 1 patient had DM with malignancy; 2 patients had juvenile DM; and 2 patients had DM/PM with other rheumatologic diseases...
December 2010: Clinical Rheumatology
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