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https://www.readbyqxmd.com/read/29456674/inflammation-responses-in-patients-with-pulmonary-tuberculosis-in-an-intensive-care-unit
#1
Qiu-Yue Liu, Fen Han, Li-Ping Pan, Hong-Yan Jia, Qi Li, Zong-De Zhang
Pulmonary tuberculosis caused by Mycobacterium tuberculosis remains a global problem. Inflammatory responses are the primary characteristics of patients with pulmonary tuberculosis in intensive care units (ICU). The aim of the present study was to investigate the clinical importance of inflammatory cells and factors for patients with pulmonary tuberculosis in ICU. A total of 124 patients with pulmonary tuberculosis in ICU were recruited for the present study. The inflammatory responses in patients with pulmonary tuberculosis in ICU were examined by changes in inflammatory cells and factors in the serum...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456642/anti-semaphorin-7a-single-chain-antibody-demonstrates-beneficial-effects-on-pulmonary-inflammation-during-acute-lung-injury
#2
Xiao Chen, Hailing Wang, Kui Jia, Hao Wang, Tao Ren
Pulmonary inflammation is a primary characteristic of lung injury initiated by the accession of immune cells into the alveolar space. Neutrophil migration serves an important role in pulmonary inflammation mediated by the migration of neutrophils into hypoxic tissue sites. The elimination of pulmonary inflammation is directly associated with rehabilitation in patients with lung injury. Anti-inflammatory treatment is essential following lung injury and ultimately determines patient outcomes. Semaphorin-7A (SEMA-7A) is a member of the Semaphorin family that influences the migration of neutrophils into hypoxic tissue sites, thus promoting inflammation...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455540/cds-nanoparticles-of-different-lengths-induce-differential-responses-in-some-of-the-liver-functions-of-mice
#3
Q Z Li, J Sun, H T Shen, S F Jia, D S Bai, D Ma
Cadmium sulfide nanoparticles (CdS NPs) are one of important nanoparticle materials which are widely used in photoelectric production, but their potential health hazard to the liver is not clear. This study is aimed at exploring the possible mechanisms of liver injury induced by CdS NPs. Male mice were treated with nanoparticles of 110-130 nm and 80-100 nm cadmium sulfide. The main methods were based on detecting the vigor of superoxide dismutase (SOD) and glutathione (GSH), and content of malondialdehyde (MDA) in both blood and liver tissues as well as on observing the pathological changes in liver tissue...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29453962/an-autoantibody-against-human-dna-topoiomerase-i-is-a-novel-biomarker-for-non-small-cell-lung-cancer
#4
Wen-Bin Wu, Shang-Mian Yie, Shang-Rong Ye, Ke Xie, Jian-Bo Zhang, Mei Cao, Jie Chen, Xu He, Xiao-Li Ma, Jia Zhang
BACKGROUND: We previously reported a novel tumor associated antigen with a molecular weight around 48 kDa that was a fragment derived from human DNA-topoiomerase I. The aim of this study is to further investigate the clinical significance of the autoantibody in patients with non-small cell lung cancer (NSCLC). METHODS: We determined serum levels of the autoantibody in 127 NSCLC patients, 127 age-, gender- and smoking history-matched healthy controls, and 38 patients with pulmonary benign tumors by using a specific enzyme linked immunosorbent assay (ELISA) for the autoantibody...
February 14, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29453299/pulmonary-sarcoidosis-with-and-without-extrapulmonary-involvement-a-cross-sectional-and-observational-study-in-china
#5
Cheng-Wei Li, Ru-Jia Tao, Dan-Feng Zou, Man-Hui Li, Xin Xu, Wei-Jun Cao
OBJECTIVES: Sarcoidosis is a multisystem disease characterised by the formation of granulomas within various organs, mainly the lungs. Several studies from different countries have been undertaken to investigate sarcoidosis with extrapulmonary involvement except from China. The objective of this study is to investigate a comparative clinical analysis in patients with pulmonary sarcoidosis with and without extrapulmonary involvement from China. METHODS: Data from inpatients diagnosed with sarcoidosis at Shanghai Pulmonary Hospital (Shanghai, China) between January 2009 and December 2014 were retrospectively collected and analysed...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29441434/a-nonhuman-primate-pet-study-measurement-of-brain-pde4-occupancy-by-roflumilast-using-r-11-c-rolipram
#6
Akihiro Takano, Tolga Uz, Jesus Garcia-Segovia, Max Tsai, Gezim Lahu, Nahid Amini, Ryuji Nakao, Zhisheng Jia, Christer Halldin
PURPOSE: Phosphodiesterase 4 (PDE4) inhibition in the brain has been reported to improve cognitive function in animal models. Therefore, PDE4 inhibitors are one of key targets potential for drug development. Investigation of brain PDE4 occupancy would help to understand the effects of PDE4 inhibition to cognitive functions. Roflumilast is a selective phosphodiesterase type 4 (PDE4) inhibitor used clinically for severe chronic obstructive pulmonary disease, but the effects to the brain have not been well investigated...
February 13, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29437149/transgelin-2-as-a-therapeutic-target-for-asthmatic-pulmonary-resistance
#7
Lei-Miao Yin, Yu-Dong Xu, Ling-Ling Peng, Ting-Ting Duan, Jia-Yuan Liu, Zhijian Xu, Wen-Qian Wang, Nan Guan, Xiao-Jie Han, Hai-Yan Li, Yu Pang, Yu Wang, Zhaoqiang Chen, Weiliang Zhu, Linhong Deng, Ying-Li Wu, Guang-Bo Ge, Shuang Huang, Luis Ulloa, Yong-Qing Yang
There is a clinical need for new bronchodilator drugs in asthma, because more than half of asthmatic patients do not receive adequate control with current available treatments. We report that inhibition of metallothionein-2 protein expression in lung tissues causes the increase of pulmonary resistance. Conversely, metallothionein-2 protein is more effective than β 2 -agonists in reducing pulmonary resistance in rodent asthma models, alleviating tension in tracheal spirals, and relaxing airway smooth muscle cells (ASMCs)...
February 7, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29409619/lung-function-and-pulmonary-artery-blood-flow-following-prenatal-maternal-retinoic-acid-and-imatinib-in-the-nitrofen-model-of-congenital-diaphragmatic-hernia
#8
Carmen Mesas Burgos, Marcus G Davey, John S Riley, Huimin Jia, Alan W Flake, William H Peranteau
BACKGROUND: Lung and pulmonary vascular maldevelopment in congenital diaphragmatic hernia (CDH) results in significant morbidity and mortality. Retinoic acid (RA) and imatinib have been shown to improve pulmonary morphology following prenatal administration in the rat nitrofen-induced CDH model. It remains unclear if these changes translate into improved function. We evaluated the effect of prenatal RA and imatinib on postnatal lung function, structure, and pulmonary artery (PA) blood flow in the rat CDH model...
December 19, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29391781/a-new-pulmonary-rehabilitation-maintenance-strategy-through-home-visiting-and-phone-contact-in-copd
#9
Yi Li, Jing Feng, Yuechuan Li, Wei Jia, Hongyu Qian
Background: The benefit of pulmonary rehabilitation (PR) for patients with COPD diminishes over time. We investigated a new strategy involving home-visit and phone contact and compared this to usual care in maintenance of PR benefits. Methods: A total of 172 stable COPD patients receiving 8-week PR program were recruited for this prospective study. Patients were allocated into usual care group (UC) and PR maintenance group (PRMG) randomly. Patients in PRMG participated in maintenance strategy at home under supervision through home-visit and phone contact...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29390275/synchronous-diffuse-large-b-cell-lymphoma-of-the-stomach-and-small-cell-lung-carcinoma-a-case-report
#10
Jia Li, Changli Zhou, Wanqi Liu, Xun Sun, Xiangwei Meng
RATIONALE: The synchronous occurrence of lung cancer in patients with gastric neoplasms is relatively uncommon, especially the cases of synchronous coexistence of small cell lung carcinoma and diffuse large B-cell lymphoma of the stomach. PATIENT CONCERNS: We encountered a case of synchronous primary small cell lung carcinoma and diffuse large B-cell lymphoma of the stomach. A 63-year-old patient with a 7.5 × 5.09 cm mass in the superior lobe of the right lung diagnosed with small cell lung cancer and synchronous diffuse large B-cell lymphoma of the stomach...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384901/acupuncture-for-idiopathic-pulmonary-fibrosis-protocol-for-a-systematic-review
#11
Yang Xie, Jia-Jia Wang, Gao-Yang Li, Xuan-Lin Li, Jian-Sheng Li
BACKGROUND: Patients with idiopathic pulmonary fibrosis (IPF) often suffer from progressive worsening of dyspnea and lung function. Although 2 drugs are now available for IPF treatment, many gaps are still to be filled. Evidences suggest that there may be some beneficial effect of acupuncture on pulmonary diseases. This review aims to systematically determine the efficacy and safety of acupuncture for treating IPF. METHODS: The following 8 databases will be searched from their inception to March 20, 2017: PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chongqing VIP, and Wanfang Data...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29375717/diagnosis-clinicopathological-characteristics-and-prognosis-of-pulmonary-mucinous-adenocarcinoma
#12
Fei Sun, Pengcheng Wang, Yiming Zheng, Weiguang Jia, Fuxing Liu, Wei Xiao, Jingjing Bao, Song Wang, Kaijin Lu
Primary pulmonary mucinous adenocarcinoma (PPMA) is an uncommon subtype of lung adenocarcinoma. The present study attempted to clarify the diagnosis, clinicopathological characteristics, and pathologic significance of epithelial growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) mutations and the prognosis of PPMA. A total of 29 patients with PPMA from among 1,469 surgically resected patients with lung adenocarcinoma were enrolled. All of the tumours expressed CK7 and 5 cases exhibited co-expression with CK20...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29366678/galectin-3-enhances-avian-h5n1-influenza-a-virus-induced-pulmonary-inflammation-by-promoting-nlrp3-inflammasome-activation
#13
Yu-Jung Chen, Sheng-Fan Wang, I-Chun Weng, Ming-Hsiang Hong, Tzu-Han Lo, Jia-Tsrong Jan, Li-Chung Hsu, Huan-Yuan Chen, Fu-Tong Liu
Highly pathogenic avian influenza A H5N1 virus causes pneumonia and acute respiratory distress syndrome in humans. Virus-induced excessive inflammatory response contributes to severe disease and high mortality rates. Galectin-3, a β-galactoside-binding protein widely distributed in immune and epithelial cells, regulates various immune functions and modulates microbial infections. Here we describe galectin-3 up-regulation in mouse lung tissue following challenges with the H5N1 influenza virus. We investigated the effects of endogenous galectin-3 on H5N1 infection and found that survival of galectin-3 knockout (Gal-3KO) mice was comparable to wild-type (WT) mice following infections...
January 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29364486/dexamethasone-alleviates-allergic-asthma-immature-rat-through-toll-like-receptor-4
#14
Z-R Wang, Q Wang, Y Sui, Z-L Zhang, F-J Jia, J Fan, Z-J Zhang
OBJECTIVE: The allergic asthma model induced by ovalbumin (OVA) was established in the immature rat. Dexamethasone (DXM) was adopted for intervention to analyze the treatment effect and to explore the relationship with toll-like receptor 4 (TLR4). MATERIALS AND METHODS: Immature SD rat was treated by OVA to construct allergic asthma model and intervened by DXM. The rats were randomly divided into model group, experimental group, and control group. The changes in lung tissue were observed by light microscope...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29363513/anti-nt5c1a-autoantibodies-are-associated-with-more-severe-disease-in-patients-with-juvenile-myositis
#15
Richard M Yeker, Iago Pinal-Fernandez, Takayuki Kishi, Katherine Pak, Ira N Targoff, Frederick W Miller, Lisa G Rider, Andrew L Mammen
OBJECTIVES: Autoantibodies recognising cytosolic 5'-nucleotidase 1A (NT5C1A) are found in adult patients with myositis and other autoimmune diseases. They are especially prevalent in adults with inclusion body myositis (IBM), in which they are associated with more severe weakness and higher mortality. This study was undertaken to define the prevalence and clinical features associated with anti-NT5C1A autoantibodies in juvenile myositis. METHODS: We screened sera from 380 patients with juvenile myositis, 30 patients with juvenile idiopathic arthritis (JIA) and 92 healthy control children for anti-NT5C1A autoantibodies...
January 23, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29359241/utility-of-retrievable-inferior-vena-cava-filters-a-systematic-literature-review-and-analysis-of-the-reasons-for-nonretrieval-of-filters-with-temporary-indications
#16
Zhongzhi Jia, Tyler A Fuller, J Mark McKinney, Ricardo Paz-Fumagalli, Gregory T Frey, David M Sella, Thuong Van Ha, Weiping Wang
OBJECTIVE: To investigate the use of retrievable inferior vena cava (IVC) filters in the current practice and analyze the causes of filter left in situ despite initial plans for retrieval. METHODS: A systematic search of all English-language studies of retrievable IVC filters was conducted, including clinical trials and observational studies published between January 1984 and March 2016. RESULTS: A total of 103 studies were identified, including 10 filter models in 20,319 patients...
January 22, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29357862/the-mortality-risk-factor-of-community-acquired-pneumonia-patients-with-chronic-obstructive-pulmonary-disease-a-retrospective-cohort-study
#17
Ruo-Xuan Dai, Qing-Hua Kong, Bei Mao, Wen Xu, Ru-Jia Tao, Xiao-Ru Wang, Qing-Yao Kong, Jin-Fu Xu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the most common comorbidities in community acquired pneumonia (CAP) patients. We aimed to investigate the characteristics and mortality risk factors of COPD patients hospitalized with CAP. METHODS: A retrospective cohort study was conducted at Shanghai Pulmonary Hospital and Shanghai Dahua Hospital. Clinical and demographic data in patients diagnosed with CAP were collected between January 2015 and June 2016...
January 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29351431/feasibility-of-phase-contrast-cine-magnetic-resonance-imaging-for-measuring-blood-flow-in-the-sheep-fetus
#18
An Qi Duan, Jack R T Darby, Jia Yin Soo, Mitchell C Lock, Meng Yuan Zhu, Lucy V Flynn, Sunthara Rajan Perumal, Christopher K Macgowan, Joseph B Selvanayagam, Janna L Morrison, Mike Seed
Phase-contrast cine MRI (PC-MRI) is the gold-standard non-invasive technique for measuring vessel blood flow and has previously been applied in the human fetal circulation. We aimed to assess the feasibility of using PC-MRI to define the distribution of the fetal circulation in sheep. Fetuses were catheterized at 119-120 days gestation (term, 150 days) and underwent MRI at 123 days gestation under isoflurane anesthesia, ventilated at a FiO2 of 1.0. PC-MRI was performed using a fetal arterial blood pressure catheter signal for cardiac triggering...
December 13, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29341224/comparative-rna-seq-transcriptome-analysis-on-silica-induced-pulmonary-inflammation-and-fibrosis-in-mice-silicosis-model
#19
Jiayi Chen, Yuqin Yao, Xiaolan Su, Ying Shi, Xuejiao Song, Linshen Xie, Jia You, Liantian Tian, Luo Yang, Aiping Fang, Jingyuan Xiong
Silicosis is a long-established public health issue in developing countries due to increasingly serious air pollution and poorly implemented occupational safety regulation. Inhalation of silica triggers cytotoxicity, oxidative stress, pulmonary inflammation and eventually silicosis. Current understanding in the pathogenesis and mechanism of silicosis is limited, and no effective cure is clinically available once silicosis is developed. A number of studies were conducted to investigate silica-induced alternate gene expressions in pulmonary cells...
January 16, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29339516/human-airway-branch-variation-and-chronic-obstructive-pulmonary-disease
#20
Benjamin M Smith, Hussein Traboulsi, John H M Austin, Ani Manichaikul, Eric A Hoffman, Eugene R Bleecker, Wellington V Cardoso, Christopher Cooper, David J Couper, Stephen M Dashnaw, Jia Guo, MeiLan K Han, Nadia N Hansel, Emlyn W Hughes, David R Jacobs, Richard E Kanner, Joel D Kaufman, Eric Kleerup, Ching-Long Lin, Kiang Liu, Christian M Lo Cascio, Fernando J Martinez, Jennifer N Nguyen, Martin R Prince, Stephen Rennard, Stephen S Rich, Leora Simon, Yanping Sun, Karol E Watson, Prescott G Woodruff, Carolyn J Baglole, R Graham Barr
Susceptibility to chronic obstructive pulmonary disease (COPD) beyond cigarette smoking is incompletely understood, although several genetic variants associated with COPD are known to regulate airway branch development. We demonstrate that in vivo central airway branch variants are present in 26.5% of the general population, are unchanged over 10 y, and exhibit strong familial aggregation. The most common airway branch variant is associated with COPD in two cohorts (n = 5,054), with greater central airway bifurcation density, and with emphysema throughout the lung...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
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