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https://www.readbyqxmd.com/read/29036983/-research-progress-on-the-treatment-of-pulmonary-arterial-hypertension-with-treprostinil
#1
Q Wu, L Jia, Z C Jing
No abstract text is available yet for this article.
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29033186/a-preliminary-study-on-fetal-lung-injury-in-a-rat-model-of-acute-pancreatitis-in-pregnancy
#2
Liang Zhao, Teng Zuo, Qiao Shi, Fang-Chao Mei, Yu-Pu Hong, Wen-Hong Deng, Jia Yu, Peng Hu, Wei-Xing Wang
Acute pancreatitis in pregnancy (APIP), which was thought to be rare, is becoming more frequent. In addition, high perinatal mortality among fetuses has been reported. Our research aimed to investigate and assess fetal lung injury in a rat model of APIP and its possible mechanisms. The APIP model was induced by sodium taurocholate in Sprague-Dawley rats during the third trimester. Sham-operated (SO) rats in late gestation were used as controls, and dynamic observation and detection in the SO and acute pancreatitis (AP) groups were performed at 3 time-points...
September 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29030006/dexmedetomidine-mitigate-acute-lung-injury-by-inhibiting-il-17-induced-inflammatory-reaction
#3
Yong Zhang, Shushan Jia, Tianqin Gao, Ruyi Zhang, Zhaoguo Liu, Yaoqi Wang
Interleukin-17 (IL-17) is considered to play an important role in the pathogenesis of a number of inflammatory conditions. Previous studies demonstrated that intranasal injections of IL-17 resulted in pulmonary inflammation and lung damage, we therefore hypothesize that dexmedetomidine, a potent α2 adrenergic receptor agonist that shows anti-inflammation effects in several animal models of inflammation, would attenuate IL-17 induced lung injury. We examined the lung damage using a histological approach, and assessed the number of lung-infiltrating neutrophils in the bronchoalveolar lavage fluid...
October 7, 2017: Immunobiology
https://www.readbyqxmd.com/read/29029334/effect-of-long-term-hydroxychloroquine-on-vascular-events-in-patients-with-systemic-lupus-erythematosus-a-database-prospective-cohort-study
#4
Chung-Yuan Hsu, Yu-Sheng Lin, Yu-Jih Su, Hsing-Fen Lin, Ming-Shyan Lin, Ya-Jhu Syu, Tien-Tsai Cheng, Shan-Fu Yu, Jia-Feng Chen, Tien-Hsing Chen
Objectives: The incidence of thromboembolism in patients with SLE is higher than that in the general population. HCQ, widely used to treat lupus, may have vascular protective effects. The aim of this study was to determine whether long-term HCQ exposure is associated with decreased thromboembolism risk in SLE. Methods: We designed a prospective cohort study within an SLE population based on the National Health Insurance Research Database in Taiwan. We divided participants into HCQ and control groups according to HCQ prescription during the first year...
September 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/29019873/reconstruction-left-atrium-and-isolation-pulmonary-veins-of-paroxysmal-atrial-fibrillation-using-single-contact-force-catheter-with-zero-x-ray-exposure-a-consort-study
#5
Jian Qiang Zhang, Rong Hui Yu, Jia Bing Liang, De Yong Long, Cai Hua Sang, Chang Sheng Ma, Jian Zeng Dong
BACKGROUND: Conventional ablation of paroxysmal atrial fibrillation (PAF) is associated with radiation risks for patients and laboratory staff. Three-dimensional (3D) mapping system capable of showing contact force (CF) and direction of catheter tip may compensate for nonfluoroscopic safety issues. OBJECTIVE: The aim of this study was to investigate the feasibility of zero x-ray exposure during reconstruction left atrium (LA) and ablation. METHODS: Single, CF catheter, and 3D mapping system were used to reconstruct LA and isolate pulmonary veins (PV) in all patients...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29017779/targeted-inhibition-of-hantavirus-replication-and-intracranial-pathogenesis-by-a-chimeric-protein-delivered-sirna
#6
Jie Yang, Ji-Feng Sun, Ting-Ting Wang, Xiao-Hong Guo, Jun-Xia Wei, Lin-Tao Jia, An-Gang Yang
Hantavirus (HV) infection, which underlies hantavirus hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome, remains to be a severe clinical challenge. Here, we synthesized small interfering RNAs (siRNAs) that target the encoding sequences of HV strain 76-118, and validated their inhibitory role in virus replication in HV-infected monkey kidney Vero E6 cells. A chimeric protein, 3G1-Cκ-tP, consisting of a single-chain antibody fragment (3G1) against the HV surface envelop glycoprotein, the constant region of human immunoglobulin κ chain (Cκ), and truncated protamine (amino acids 8-29, tP), was further generated...
October 7, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28969737/isolated-rectal-tuberculosis-diagnosed-with-empirical-anti-tuberculous-therapy
#7
Liu Liu, Xiapeng Luo, He Huang, Huangwei Chen, Hai He, Xiaoyan Liang, Liuping Jia
Isolated rectal tuberculosis (TB) is a rare condition, even in those parts of the world, where pulmonary TB is common. Herein, we report a case of 29-year female patient with isolated rectal TB, who presented with features of abdominal pain and bloody purulent stool. She was diagnosed by empirical anti-TB treatment due to lack of specific imaging, endoscopic, immunological, histopathological and etiological findings.
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28969003/combination-of-cadherin-17-and-satb-homeobox-2-serves-as-potential-optimal-makers-for-the-differential-diagnosis-of-pulmonary-enteric-adenocarcinoma-and-metastatic-colorectal-adenocarcinoma
#8
Tingting Bian, Jinli Zhao, Jia Feng, Qing Zhang, Li Qian, Jian Liu, Daishan Jiang, Yifei Liu, Jianguo Zhang
BACKGROUND: Pulmonary enteric adenocarcinoma (PEAC), a rare type of non-small cell lung cancer, has similar histological and immunohistochemical morphology to colorectal adenocarcinoma. Cadherin-17 (CDH17) and SATB homeobox 2 (SATB2) immunoexpression have recently been demonstrated in colorectal adenocarcinoma. In this study, we evaluated the value of CDH17 and SATB2 in the diagnosis of pulmonary enteric adenocarcinoma and metastatic colorectal adenocarcinoma. METHODS: A total of 13 PEAC cases and 27 metastatic colorectal adenocarcinoma cases were enrolled in our cohort study...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28962220/clinical-study-on-the-changes-of-lung-specific-proteins-cc16-after-lung-contusion
#9
Meng-Ni Wen, Gang Zhao, Jia-Ying Zhang, Yong-Hong Zhao
The aim of the present study was to examine the clinical value of continuously monitoring serum CC16 levels in diagnosing pulmonary contusion, estimating its severity degree and predicting disease progression. Thirty-one acute trauma patients with lung contusion diagnosed by chest computed tomography (CT) were included, and chest CT was re-examined on day 1, 3 and 7 after injury. Calculating all the contusion volume by the Siemens syngo volume calculation program, complications such as pleural effusion or atelectasis were observed and recorded...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28962198/analysis-of-risk-factors-for-post-operative-complications-and-prognostic-predictors-of-disease-recurrence-following-definitive-treatment-of-patients-with-esophageal-cancer-from-two-medical-centers-in-northwest-china
#10
Jichang Wang, Boxiang Zhang, Jinying Meng, Guodong Xiao, Xiang Li, Gang Li, Sida Qin, Ning Du, Jia Zhang, Jing Zhang, Chongwen Xu, Shou-Ching Tang, Rui Liang, Hong Ren, Xin Sun
Evaluating the clinicopathological features of patients receiving definitive treatment for esophageal cancer may facilitate the identification of patterns and factors associated with post-operative complications, and enable the development of a surveillance strategy for surviving patients at a higher risk of disease recurrence. In the present study, clinical data from 579 patients with esophageal cancer that underwent radical resection of esophagus were collected. These patients were admitted to two medical centers in Northwest China, and information regarding the presence or absence of basic chronic diseases and post-operative results were retrospectively analyzed...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28962147/naringenin-ameliorates-lps-induced-acute-lung-injury-through-its-anti-oxidative-and-anti-inflammatory-activity-and-by-inhibition-of-the-pi3k-akt-pathway
#11
Minghong Zhao, Chao Li, Fujun Shen, Meijuan Wang, Ning Jia, Chunbin Wang
The aim of the present study was to explore the effect of naringenin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in a mouse model, as well as the underlying mechanism. The animals were randomly assigned to four groups: PBS-treated healthy control (Control), LPS-induced ALI (LPS), vehicle-treated ALI (LPS + Vehicle), and naringenin-treated ALI (LPS + Nar) group. Naringenin (100 mg/kg) was administered orally for 4 consecutive days, starting 3 days prior to induction of ALI. The survival rates of mice, lung wet/dry weight ratios, lung injury score, protein levels of bronchoalveolar lavage fluid (BALF), lactate dehydrogenase (LDH) activity in the BALF, lung myeloperoxidase (MPO) activity, the number of infiltrated neutrophils and reactive oxygen species (ROS) levels (H2O2 and malondialdehyde) were assessed...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28962107/experimental-study-of-airway-pressure-release-ventilation-in-the-treatment-of-acute-respiratory-distress-syndrome
#12
Guan-Jie Han, Jia-Qiong Li, Cui-Gai Pan, Jing-Xi Sun, Zai-Xiang Shi, Ji-Yuan Xu, Mao-Qin Li
Airway pressure release ventilation (APRV) is a ventilator mode which has demonstrated potential benefits in acute respiratory distress syndrome (ARDS) patients. We therefore sought to compare relevant pulmonary data and safety outcomes of this mode to the conventional ventilation and sustained inflation. Canines admitted after intravenous injection of oleic acid requiring mechanical ventilation were randomly divided into 3 groups (n=6), namely conventional ventilation group, low tidal volume ventilation with recruitment group (LTV+SI) and APRV group...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28949968/normalisation-of-surfactant-protein-a-and-b-expression-in-the-lungs-of-low-birth-weight-lambs-by-21-days-old
#13
Jia Yin Soo, Sandra Orgeig, Erin Victoria McGillick, Song Zhang, I Caroline McMillen, Janna L Morrison
Intrauterine growth restriction (IUGR) induced by placental restriction (PR) in the sheep negatively impacts lung and pulmonary surfactant development during fetal life. Using a sheep model of low birth weight (LBW), we found that there was an increase in mRNA expression of surfactant protein (SP)-A, -B and -C in the lung of LBW lambs but no difference in the protein expression of SP-A or -B. LBW also resulted in increased lysosome-associated membrane glycoprotein (LAMP)-3 mRNA expression, which may indicate an increase in either the density of type II Alveolar epithelial cells (AEC) or maturity of type II AECs...
2017: PloS One
https://www.readbyqxmd.com/read/28948165/expression-and-role-of-oct3-4-in-injury-repair-process-of-rat-alveolar-epithelium-after-5-fu-treatment
#14
Wen-Ya Li, Xu-Lv Ye, Xin-Shan Jia, Lan-Ling Jia
OBJECTIVE: We aimed to investigate how the embryonic stem cell-related gene Oct3/4 changes during the injury-repair process of distal pulmonary epithelium induced by 5-fluorouracil (5-Fu). METHODS: We have developed the lung injury model induced by 5-Fu and observed the dynamic changes of Oct3/4 by indirect immunofluorescence, Western blot, and quantitative real-time PCR. Immunofluorescence double staining was used to compare the positions of Oct3/4(+) cells and other reported alveolar epithelial stem cells...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28942149/fibulin-5-promotes-airway-smooth-muscle-cell-proliferation-and-migration-via-modulating-hippo-yap-taz-pathway
#15
Jia Fu, Mao Zheng, Xiaofang Zhang, Yufeng Zhang, Yao Chen, Hua Li, Xiaowei Wang, Jinjun Zhang
Asthma is a common chronic disease mainly occurs from childhood. Increased airway smooth muscle mass is involved in the pathogenesis of asthma. Fibulin-5 was upregulated in the lung tissues of patients with COPD and idiopathic pulmonary fibrosis. This study aimed to investigate Fibulin-5 expression in asthmatic patients and the effect and mechanism of Fibulin-5 on the proliferation and migration of airway smooth muscle cells (ASMCs). The expression of Fibulin-5, YAP, and TAZ in the induced sputum of 38 asthmatic children (19 mild and 19 moderate asthmatics) and 19 healthy controls was determined...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28938639/spondin2-is-a-new-prognostic-biomarker-for-lung-adenocarcinoma
#16
Xiaopeng Yuan, Tingting Bian, Jian Liu, Honggang Ke, Jia Feng, Qing Zhang, Li Qian, Xiaoli Li, Yifei Liu, Jianguo Zhang
Spondin 2 (SPON2) is a member of the F-spondin superfamily of genes that encode an extracellular matrix protein. SPON2 has been identified by mRNA differential display screening of cancerous and noncancerous lung cell lines in vitro [1], however, its role in pulmonary adenocarcinoma (ADC) patients remains unclear. In our study, we evaluated whether SPON2 can be used as a biomarker for the diagnosis of pulmonary ADC and any association between SPON2 protein levels and clinicopathological characteristics. Firstly, the mRNA levels of SPON2 in pulmonary ADCs and normal adjacent tissue samples were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR) (n = 60) assay and the expression of SPON2 protein were detected by tissue microarray immunohistochemistry analysis (TMA-IHC) (n = 280)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937040/surgical-outcomes-of-anomalous-origin-of-the-left-coronary-artery-from-the-pulmonary-artery-in-children-an-echocardiography-follow-up
#17
Yan Gao, Jing Zhang, Guo-Ying Huang, Xue-Cun Liang, Bing Jia, Xiao-Jing Ma
BACKGROUND: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare but potentially life-threatening congenital heart defect. A retrospective analysis was carried out to elucidate the surgical outcomes of ALCAPA in infants and children using follow-up echocardiography. METHODS: From September 2008 to March 2017, 26 children diagnosed with ALCAPA underwent left coronary re-implantation. All surviving patients received echocardiography during follow-up...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28935640/attenuation-of-pulmonary-ace2-activity-impairs-inactivation-of-des-arg9-bradykinin-bkb1r-axis-and-facilitates-lps-induced-neutrophil-infiltration
#18
Chhinder P Sodhi, Christine Wohlford-Lenane, Yukihiro Yamaguchi, Thomas Prindle, William B Fulton, Sanxia Wang, Paul B McCray, Mark C Chappell, David J Hackam, Hongpeng Jia
Angiotensin converting enzyme 2 (ACE2) is a terminal carboxypeptidase with important functions in the renin angiotensin system and plays a critical role in inflammatory lung diseases. ACE2 cleaves single terminal residues from several bioactive peptides such as angiotensin II. However, few of its substrates in the respiratory tract have been identified and the mechanism underlying the role of ACE2 in inflammatory lung disease has not been fully characterized. In an effort to identify biological targets of ACE2 in the lung, we tested its effects on des-arg9 bradykinin (DABK) in airway epithelial cells based upon a hypothesis that DABK is a biological substrate of ACE2 in the lung and ACE2 plays an important role in the pathogenesis of acute lung inflammation partly through modulating DABK/BKB1R axis signaling...
September 21, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28914716/diagnostic-utility-of-satb2-in-metastatic-krukenberg-tumors-of-the-ovary-an-immunohistochemical-study-of-70-cases-with-comparison-to-cdx2-ck7-ck20-chromogranin-and-synaptophysin
#19
Chen Yang, Li Sun, Lingxin Zhang, Lixin Zhou, Ming Zhao, Yan Peng, Dongfeng Niu, Zhongwu Li, Xiaozheng Huang, Qiang Kang, Lin Jia, Jinping Lai, Dengfeng Cao
SATB2 is a sensitive marker for colorectal adenocarcinomas. No study has investigated its diagnostic utility in metastatic Krukenberg tumors (MKTs) of the ovary. Here we performed immunohistochemical staining SATB2 in 70 MKTs of various origins (stomach 27, colorectum 13, appendix 20 including 19 metastatic adenocarcinomas ex goblet cell carcinoids [AdexGCC] and 1 conventional poorly differentiated carcinoma with signet ring cells, breast 5, bladder 3, lung 2) to assess its diagnostic utility. We also compared SATB2 with CDX2, CK7, CK20, chromogranin, and synaptophysin in MKTs of gastric origin (MKTs-stomach), those of colorectal origin (MKTs-colorectum) and those due to appendiceal AdexGCCs (MKT-AdexGCCs) for their sensitivity and specificity to distinguish these tumors...
September 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28910318/characterization-of-a-novel-panel-of-plasma-micrornas-that-discriminates-between-mycobacterium-tuberculosis-infection-and-healthy-individuals
#20
Jia-Yi Cui, Hong-Wei Liang, Xin-Ling Pan, Di Li, Na Jiao, Yan-Hong Liu, Jin Fu, Xiao-Yu He, Gao-Xiang Sun, Chun-Lei Zhang, Chi-Hao Zhao, Dong-Hai Li, En-Yu Dai, Ke Zen, Feng-Min Zhang, Chen-Yu Zhang, Xi Chen, Hong Ling
Cavities are important in clinical diagnosis of pulmonary tuberculosis (TB) infected by Mycobacterium tuberculosis. Although microRNAs (miRNAs) play a vital role in the regulation of inflammation, the relation between plasma miRNA and pulmonary tuberculosis with cavity remains unknown. In this study, plasma samples were derived from 89 cavitary pulmonary tuberculosis (CP-TB) patients, 89 non-cavitary pulmonary tuberculosis (NCP-TB) patients and 95 healthy controls. Groups were matched for age and gender. In the screening phase, Illumina high-throughput sequencing technology was employed to analyze miRNA profiles in plasma samples pooled from CP-TB patients, NCP-TB patients and healthy controls...
2017: PloS One
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