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https://www.readbyqxmd.com/read/27906672/non-toxic-dose-of-liposomal-honokiol-suppresses-metastasis-of-hepatocellular-carcinoma-through-destabilizing-egfr-and-inhibiting-the-downstream-pathways
#1
Jianhong Yang, Heying Pei, Hong Luo, Afu Fu, Hansuo Yang, Jia Hu, Chengjian Zhao, LuLu Chai, Xiang Chen, Ximing Shao, Chunyu Wang, Wenshuang Wu, Li Wan, Haoyu Ye, Qiang Qiu, Aihua Peng, Yuquan Wei, Li Yang, Lijuan Chen
At present, there is no specific anti-metastasis drug in HCC treatment. Drugs used for primary HCC tumors and tumor metastasis are very similar, among which cytotoxic drugs are prevalent, such as cisplatin, doxorubicin and 5-FU. The EGFR pathway plays an important role in promoting hepatocellular carcinoma (HCC) metastasis. Hence, development of non-toxic anti-metastasis drugs, such as EGFR or downstream pathways inhibitors, is of great importance. In our present study, we found non-toxic dose of liposomal honokiol (LH) could inhibit the HCC metastasis by destabilizing EGFR and inhibiting the downstream pathways...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27891773/cigarette-smoke-alters-the-secretome-of-lung-epithelial-cells
#2
Alessandra Mossina, Christina Lukas, Juliane Merl-Pham, Franziska E Uhl, Kathrin Mutze, Andrea Schamberger, Claudia Staab-Weijnitz, Jie Jia, Ali Ö Yildirim, Melanie Königshoff, Stefanie M Hauck, Oliver Eickelberg, Silke Meiners
Cigarette smoke is the most relevant risk factor for the development of lung cancer and chronic obstructive pulmonary disease (COPD). Many of its more than 4500 chemicals are highly reactive thereby altering protein structure and function. Here, we used subcellular fractionation coupled to label-free quantitative mass spectrometry to globally assess alterations in the proteome of different compartments of lung epithelial cells upon exposure to cigarette smoke extract. Proteomic profiling of the human alveolar-derived cell line A549 revealed the most pronounced changes within the cellular secretome with preferential downregulation of proteins involved in wound healing and extracellular matrix (ECM) organization...
November 28, 2016: Proteomics
https://www.readbyqxmd.com/read/27873481/a-case-of-pulmonary-cryptococcosis-with-large-pericardial-effusion-diagnosed-using-cervical-lymph-node-biopsy
#3
Xuchun Liu, Wei Jia, Shubin Huang, Gengyun Sun
Pulmonary cryptococcosis (PC) is a relatively rare infectious disease. It mainly involves the lungs; however, in some patients, the infection could spread to other parts of the body. PC mostly occurs in patients with immune deficiencies. However, PC infections have been reported in non-immunocompromised patients. The diagnosis of PC is challenging in patients without immune deficiencies. Here, the case of a 27-year-old immunocompetent woman who was diagnosed with PC was report. She had unexplained fever and a history of close contact with poultry feathers...
November 7, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27866544/-effects-of-chronic-exposure-to-monochloroacetic-acid-on-the-lung-function-and-lymphocyte-subsets-in-occupational-exposed-workers
#4
T Meng, J Jia, P P Miao, M L Shen, Y Niu, Y F Dai
Objective: To investigate the effects of chronic exposure to monochloroacetic acid on the lung function and whole blood counts in occupational exposed workers, and provide new markers for occupational health surveillance. Methods: We conducted a cross-sectional molecular epidemiology study of 121 workers who were occupationally exposed to monochloroacetic acid and 69 unexposed workers frequency-matched by age and smoking status from the same geographic region. The lung function was measured by portable lung function instrument, and the lymphocyte subsets were measured by flow cytometry...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27856118/computer-aided-detection-of-pulmonary-nodules-using-dynamic-self-adaptive-template-matching-and-a-flda-classifier
#5
Jing Gong, Ji-Yu Liu, Li-Jia Wang, Bin Zheng, Sheng-Dong Nie
Improving the performance of computer-aided detection (CAD) system for pulmonary nodules is still an important issue for its future clinical applications. This study aims to develop a new CAD scheme for pulmonary nodule detection based on dynamic self-adaptive template matching and Fisher linear discriminant analysis (FLDA) classifier. We first segment and repair lung volume by using OTSU algorithm and three-dimensional (3D) region growing. Next, the suspicious regions of interest (ROIs) are extracted and filtered by applying 3D dot filtering and thresholding method...
November 14, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27836304/neutrophil-gelatinase-associated-lipocalin-predicts-myocardial-dysfunction-and-mortality-in-severe-sepsis-and-septic-shock
#6
Biao Wang, Gang Chen, Jia Li, Yuanying Zeng, Yunfu Wu, Xiaoye Yan
BACKGROUND: This study examines the clinical utility of plasma neutrophil gelatinase-associated lipocalin (NGAL) as an indicator of myocardial dysfunction and mortality in severe sepsis and septic shock. METHODS: We designed a prospective cohort study in an intensive care unit, and 53 patients with severe sepsis or septic shock were included. Data were used to determine a relationship between NGAL and the development of myocardial dysfunction and mortality. These associations were determined by the Mann-Whitney test, multiple logistic regression, plotting the receiver operating characteristic (ROC) curve, Kaplan-Meier curves and Spearman test...
November 3, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27823995/analysis-of-in-hospital-neonatal-death-in-the-tertiary-neonatal-intensive-care-unit-in-china-a-multicenter-retrospective-study
#7
Chen-Hong Wang, Li-Zhong Du, Xiao-Lu Ma, Li-Ping Shi, Xiao-Mei Tong, Hong Liu, Guo-Fang Ding, Bin Yi, Xin-Nian Pan, Dan-Ni Zhong, Ling Liu, Mei Li, Cui-Qing Liu, Shi-Wen Xia, Hong-Yun Wang, Ling He, Kun Liang, Xiao-Yu Zhou, Shu-Ping Han, Qin Lyu, Yin-Ping Qiu, Ruo-Bing Shan, De-Zhi Mu, Xiao-Hong Liu, Si-Qi Zhuang, Jing Guo, Li Liu, Jia-Jun Zhu, Hong Xiong
BACKGROUND: Globally, the proportion of child deaths that occur in the neonatal period remains a high level of 37-41%. Differences of cause in neonate death exist in different regions as well as in different economic development countries. The specific aim of this study was to investigate the causes, characteristics, and differences of death in neonates during hospitalization in the tertiary Neonatal Intensive Care Unit (NICU) of China. METHODS: All the dead neonates admitted to 26 NICUs were included between January l, 2011, and December 31, 2011...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27803787/anti-inflammatory-effect-of-yu-ping-feng-san-via-tgf-%C3%AE-1-signaling-suppression-in-rat-model-of-copd
#8
Zhong-Shan Yang, Jin-Yuan Yan, Ni-Ping Han, Wei Zhou, Yu Cheng, Xiao-Mei Zhang, Ning Li, Jia-Li Yuan
OBJECTIVES: Yu-Ping-Feng-San (YPFS) is a classical traditional Chinese medicine that is widely used for treatment of the diseases in respiratory systems, including chronic obstructive pulmonary disease (COPD) recognized as chronic inflammatory disease. However, the molecular mechanism remains unclear. Here we detected the factors involved in transforming growth factor beta 1 (TGF-β1)/Smad2 signaling pathway and inflammatory cytokines, to clarify whether YPFS could attenuate inflammatory response dependent on TGF-β1/Smad2 signaling in COPD rats or cigarette smoke extract (CSE)-treated human bronchial epithelial (Beas-2B) cells...
September 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27778265/synchronous-dynamic-research-on-respiratory-and-intestinal-microflora-of-chronic-bronchitis-rat-model
#9
Xiu-Li Zheng, Yu Yang, Bao-Jia Wang, Ju Wang, Hong-Qu Tang
OBJECTIVE: To investigate the mechanism of the Chinese medicine theory that Fei (Lung) and Dachang (Large Intestine) are exteriorly and interiorly related via synchronous observation on the dynamic changes of the respiratory and intestinal microflora. METHODS: Forty specific pathogen free Sprague-Dawley rats were selected and randomly divided into blank (10 rats) and chronic bronchitis model groups (30 rats). The blank group rats were put into the smoke-free environment and the model group rats were put into the smoke environment in order to establish pulmonary disease (chronic bronchitis) model...
October 24, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27775945/diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia-and-granulomatous-inflammation-mimicking-high-grade-malignancy-on-fdg-pet-ct
#10
Joyce Hsu, Leo Jia, Darko Pucar, Hadyn Williams, Jayanth Keshavamurthy
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare form of preinvasive lung lesion associated with indolent carcinoid tumor formation. This disease is characterized by multiple small pulmonary nodules with low SUVmax on F-FDG PET. Biopsy and immunohistochemical staining for neuroendocrine markers confirm diagnosis. There is no consensus for treatment, which typically involves surgical excision or management of symptoms with steroid-based therapies. We report an unusual case of DIPNECH colocalizing with necrotizing granulomatous inflammation mimicking high-grade aggressive malignancy on FDG-PET and a typical case of DIPNECH for comparison with low FDG avidity...
January 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27746262/caffeic-acid-phenethyl-ester-alleviates-asthma-by-regulating-the-airway-microenvironment-via-the-ros-responsive-mapk-akt-pathway
#11
REVIEW
Yuan Ma, Jia-Xiang Zhang, Ya-Nan Liu, Ai Ge, Hao Gu, Wang-Jian Zha, Xiao-Ning Zeng, Mao Huang
In the pathophysiology of asthma, structural cell dysfunction and concomitant microenvironment changes in airways are crucial to pathological progression, which involves oxidative stress. Caffeic acid phenethyl ester (CAPE) is an active anti-oxidative component obtained from propolis, and has been shown to have beneficial effects on several respiratory disorders, such as chronic obstructive pulmonary disease and lung cancer. However, the impact of CAPE on asthma is not well understood. Therefore, this study investigated the advantages of using CAPE to treat asthma and demonstrated the roles of CAPE in the regulation of airway microenvironments...
October 13, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27743123/effect-of-comorbidities-on-postoperative-complications-in-patients-with-gastric-cancer-after-laparoscopy-assisted-total-gastrectomy-results-from-an-8-year-experience-at-a-large-scale-single-center
#12
Jia-Bin Wang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Chang-Ming Huang
BACKGROUND: Comorbidity is a predictor of postoperative complications in gastrectomy. However, it remains unclear which comorbidities are predictors of postoperative complications in gastric cancer patients who have undergone laparoscopy-assisted total gastrectomy (LATG). The purpose of this study was to evaluate the effect of comorbidities on the surgical outcomes of patients with gastric cancer after LATG. METHODS: We retrospectively collected data on 1657 gastric cancer patients who underwent LATG between January 2008 and December 2015...
October 14, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27737815/effect-of-tongxinluo-on-pulmonary-hypertension-and-pulmonary-vascular-remodeling-in-rats-exposed-to-a-low-pressure-hypoxic-environment
#13
Yong Wang, Ting-Ting Ma, Na-Na Gao, Xiao-Ling Zhou, Jiang Hong, Rui Guo, Li-Na Jia, Hong Chang, Ying Gao, Zhi-Min Gao, Lei Pan
ETHNOPHARMACOLOGICAL RELEVANCE: Tongxinluo (TXL),which is a Chinese medicine rooted from traditional used herbs, has been used in clinic to treat cardiovascular and cerebrovascular diseases. However, it remains unknown whether TXL alleviates low pressure hypoxic pulmonary hypertension. AIM OF THE STUDY: Here, we aimed to observe the influence of TXL on pulmonary hypertension in a rat model that exposed to high altitude environment characterized by low pressure hypoxia...
October 10, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27734186/estimation-of-right-ventricular-dysfunction-by-computed-tomography-pulmonary-angiography-a-valuable-adjunct-for-evaluating-the-severity-of-acute-pulmonary-embolism
#14
Dong Jia, Xiao-Ming Zhou, Gang Hou
To evaluate the feasibility and the efficacy of computed tomography pulmonary angiography (CTPA) in differentiating acute pulmonary embolism (PE) patients with or without right ventricular dysfunction and to evaluate the severity of right ventricular dysfunction in acute PE patients with CPTA. We retrospectively collected and measured the following parameters: right ventricular diameter by short axis in the axial plane (RVDaxial), left ventricular diameter by short axis in the axial plane (LVDaxial), right ventricular diameter by level on the reconstructed four-chamber views (RVD4-CH), left ventricular diameter by level on the reconstructed four-chamber views (LVD4-CH), main pulmonary artery diameter (MPAD), ascending aorta diameter (AOD), coronary sinus diameter (CSD), superior vena cava diameter (SVCD), inferior vena cava (IVC) reflux and interventricular septum deviation by CTPA, and we calculated the RVDaxial/LVDaxial, RVD4-CH/LVD4-CH and MPAD/AOD ratios in acute PE patients...
October 12, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27721913/role-of-endogenous-sulfur-dioxide-in-regulating-vascular-structural-remodeling-in-hypertension
#15
Jia Liu, Yaqian Huang, Selena Chen, Chaoshu Tang, Hongfang Jin, Junbao Du
Sulfur dioxide (SO2), an emerging gasotransmitter, was discovered to be endogenously generated in the cardiovascular system. Recently, the physiological effects of endogenous SO2 were confirmed. Vascular structural remodeling (VSR), an important pathological change in many cardiovascular diseases, plays a crucial role in the pathogenesis of the diseases. Here, the authors reviewed the research progress of endogenous SO2 in regulating VSR by searching the relevant data from PubMed and Medline. In spontaneously hypertensive rats (SHRs) and pulmonary hypertensive rats, SO2/aspartate aminotransferase (AAT) pathway was significantly altered...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27717760/ct-pulmonary-angiography-using-automatic-tube-current-modulation-combination-with-different-noise-index-with-iterative-reconstruction-algorithm-in-different-body-mass-index-image-quality-and-radiation-dose
#16
Yong-Xia Zhao, Zi-Wei Zuo, Hong-Na Suo, Jia-Ning Wang, Jin Chang
RATIONALE AND OBJECTIVES: This study aimed to determine the appropriate body mass index (BMI)-dependent noise index (NI) setting in computed tomography pulmonary angiography (CTPA) with automatic tube current modulation with adaptive statistical iterative reconstruction (ASiR). MATERIALS AND METHODS: A total of 480 patients who had a CTPA were divided into group A (18.5 kg/m(2) ≤ BMI < 25 kg/m(2)), group B (25 kg/m(2) ≤ BMI < 30 kg/m(2)), and group C (BMI ≥ 30 kg/m(2)), according to their BMI values; each group had 160 patients...
October 4, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27717503/btla-expressing-cd11c-antigen-presenting-cells-in-patients-with-active-tuberculosis-exhibit-low-capacity-to-stimulate-t-cell-proliferation
#17
Wan-Dang Wang, Yu-Chi Gao, Yuan-Bin Lu, Jun-Ai Zhang, Gan-Bin Liu, Bin Kong, Wen-Yu Xiang, You-Chao Dai, Shi-Yan Yu, Yan Jia, Xiao-Xia Fu, Lai-Long Yi, Bin-Ying Zheng, Zheng W Chen, Jixin Zhong, Jun-Fa Xu
Despite past extensive studies on B and T lymphocyte attenuator (BTLA)-mediated negative regulation of T cell activation, the role of BTLA in antigen presenting cells (APCs) in patients with active pulmonary tuberculosis (ATB) remains poorly understood. Here, we demonstrate that BTLA expression on CD11c APCs increased in patients with ATB. Particularly, BTLA expression in CD11c APCs was likely associated with the attenuated stimulatory capacity on T cells (especially CD8+ T cell) proliferation. BTLA-expressing CD11c APCs showed lower antigen uptake capacity, lower CD86 expression, higher HLA-DR expression, and enhanced IL-6 secretion, compared to counterpart BTLA negative CD11c APCs in healthy controls (HC)...
September 30, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27713629/importance-of-fractional-exhaled-nitric-oxide-in-the-differentiation-of-asthma-copd-overlap-syndrome-asthma-and-copd
#18
Feng-Jia Chen, Xin-Yan Huang, Yang-Li Liu, Geng-Peng Lin, Can-Mao Xie
BACKGROUND: Fractional exhaled nitric oxide (FeNO) is an easy, sensitive, reproducible, and noninvasive marker of eosinophilic airway inflammation. Accordingly, FeNO is extensively used to diagnose and manage asthma. Patients with COPD who share some of the features of asthma have a condition called asthma-COPD overlap syndrome (ACOS). The feasibility of using FeNO to differentiate ACOS patients from asthma and COPD patients remains unclear. METHODS: From February 2013 to May 2016, patients suspected with asthma and COPD through physician's opinion were subjected to FeNO measurement, pulmonary function test (PFT), and bronchial hyperresponsiveness or bronchodilator test...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27706945/the-role-of-mif-cyclind1-and-erk-in-the-development-of-pulmonary-hypertension-in-broilers
#19
Haoyun Li, Yanmei Wang, Lingli Chen, Lijuan Han, Lifang Li, Han He, Yuan Li, Nan Huang, Hao Ren, Fangying Pei, Guilan Li, Jia Cheng, Wenkui Wang
Pulmonary hypertension (PH) is a major disease in the broiler breeding industry. During PH, the pulmonary artery undergoes remodelling, which is caused by pulmonary vascular smooth muscle cell proliferation. CyclinD1 regulates cell proliferation. This study investigated the role of cyclinD1 in the development of PH in broilers, and which bioactivators and signalling pathway are involved in the pathological process. The PH group contained 3-4 week-old broilers with clinical PH, and the healthy group broilers from the same flock without PH...
October 6, 2016: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/27696333/soluble-epoxide-hydrolase-inhibitor-suppresses-the-expression-of-triggering-receptor-expressed-on-myeloid-cells-1-by-inhibiting-nf-kb-activation-in-murine-macrophage
#20
Liang Dong, Yong Zhou, Zhao-Qiong Zhu, Tian Liu, Jia-Xi Duan, Jun Zhang, Ping Li, Bruce D Hammcok, Cha-Xiang Guan
Triggering receptors expressed on myeloid cell-1 (TREM-1) is a superimmunoglobulin receptor expressed on myeloid cells. TREM-1 amplifies the inflammatory response. Epoxyeicosatrienoic acids (EETs), the metabolites of arachidonic acid derived from the cytochrome P450 enzyme, have anti-inflammatory properties. However, the effects of EETs on TREM-1 expression under inflammatory stimulation remain unclear. Therefore, inhibition of soluble epoxide hydrolase (sEH) with a highly selective inhibitor [1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea, TPPU] was used to stabilize EETs...
October 1, 2016: Inflammation
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